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Conserved domains on  [gi|385658043|gb|AFI65466|]
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alpha/beta fold family hydrolase [Burkholderia pseudomallei 1026b]

Protein Classification

alpha/beta hydrolase( domain architecture ID 12114401)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  12369917|19508187|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 45-283 7.07e-91

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


:

Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 269.85  E-value: 7.07e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   45 AAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYLDDADALVASAARE--NTPLFL 122
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREEhpGLPLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  123 MGHSMGGAIAALYAIERAaarhASLTGLILSSPALAPG-RDVPQWMLAMSRFISRVWPRFP-ALKIDAALLSRDPAVVAA 200
Cdd:pfam12146  81 LGHSMGGLIAALYALRYP----DKVDGLILSAPALKIKpYLAPPILKLLAKLLGKLFPRLRvPNNLLPDSLSRDPEVVAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  201 NRADPLVhHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGSPDRTLTLYEGNYHETMN 280
Cdd:pfam12146 157 YAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLN 235


                  ...
gi 385658043  281 DLE 283
Cdd:pfam12146 236 EPD 238
 
Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 45-283 7.07e-91

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 269.85  E-value: 7.07e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   45 AAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYLDDADALVASAARE--NTPLFL 122
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREEhpGLPLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  123 MGHSMGGAIAALYAIERAaarhASLTGLILSSPALAPG-RDVPQWMLAMSRFISRVWPRFP-ALKIDAALLSRDPAVVAA 200
Cdd:pfam12146  81 LGHSMGGLIAALYALRYP----DKVDGLILSAPALKIKpYLAPPILKLLAKLLGKLFPRLRvPNNLLPDSLSRDPEVVAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  201 NRADPLVhHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGSPDRTLTLYEGNYHETMN 280
Cdd:pfam12146 157 YAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLN 235


                  ...
gi 385658043  281 DLE 283
Cdd:pfam12146 236 EPD 238
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
19-297 9.33e-54

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 174.81  E-value: 9.33e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  19 PQPTRVRTADGLELACYRWPSTAPscaaPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAER 98
Cdd:COG2267    3 RRLVTLPTRDGLRLRGRRWRPAGS----PRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  99 FDRYLDDADALVASAARE-NTPLFLMGHSMGGAIAALYaierAAARHASLTGLILSSPALapgrdvpqwmlamsrfisrv 177
Cdd:COG2267   79 FDDYVDDLRAALDALRARpGLPVVLLGHSMGGLIALLY----AARYPDRVAGLVLLAPAY-------------------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 178 wprfpalkidaallsrdpavvaanRADPLVHhgsVPARTGAEIldamrRIAAGRAALRIPVLVYHGTADKLTEPDGSRDF 257
Cdd:COG2267  135 ------------------------RADPLLG---PSARWLRAL-----RLAEALARIDVPVLVLHGGADRVVPPEAARRL 182

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 385658043 258 GAHVgSPDRTLTLYEGNYHETMNDLERERVIGALIDWIAA 297
Cdd:COG2267  183 AARL-SPDVELVLLPGARHELLNEPAREEVLAAILAWLER 221
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 32-299 7.87e-41

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 146.19  E-value: 7.87e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  32 LACYRWpstAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYLDDADALVA 111
Cdd:PLN02652 123 LFCRSW---APAAGEMRGILIIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDGLHGYVPSLDYVVEDTEAFLE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 112 SAAREN--TPLFLMGHSMGGAI---AALYAIERAAarhasLTGLILSSPAL--APGRDVpqwMLAMSRFISRVWPR--FP 182
Cdd:PLN02652 200 KIRSENpgVPCFLFGHSTGGAVvlkAASYPSIEDK-----LEGIVLTSPALrvKPAHPI---VGAVAPIFSLVAPRfqFK 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 183 ALKIDAALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVG 262
Cdd:PLN02652 272 GANKRGIPVSRDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLHGTADRVTDPLASQDLYNEAA 351

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 385658043 263 SPDRTLTLYEGNYHETMNDLERERVIGALIDWIAARV 299
Cdd:PLN02652 352 SRHKDIKLYDGFLHDLLFEPEREEVGRDIIDWMEKRL 388
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 42-141 1.23e-05

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 45.96  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   42 PSCAAPRATVALVHGLAE--HAGRYQAF--AERLNAAGIEVVAIDLRGHGRSPGERAwAERFDRYLDDadalVASAAR-- 115
Cdd:TIGR03101  19 PVAVGPRGVVIYLPPFAEemNKSRRMVAlqARAFAAGGFGVLQIDLYGCGDSAGDFA-AARWDVWKED----VAAAYRwl 93

                          90       100
                  ....*....|....*....|....*....
gi 385658043  116 ---ENTPLFLMGHSMGGAIAALYAIERAA 141
Cdd:TIGR03101  94 ieqGHPPVTLWGLRLGALLALDAANPLAA 122
 
Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 45-283 7.07e-91

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 269.85  E-value: 7.07e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   45 AAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYLDDADALVASAARE--NTPLFL 122
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREEhpGLPLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  123 MGHSMGGAIAALYAIERAaarhASLTGLILSSPALAPG-RDVPQWMLAMSRFISRVWPRFP-ALKIDAALLSRDPAVVAA 200
Cdd:pfam12146  81 LGHSMGGLIAALYALRYP----DKVDGLILSAPALKIKpYLAPPILKLLAKLLGKLFPRLRvPNNLLPDSLSRDPEVVAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  201 NRADPLVhHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGSPDRTLTLYEGNYHETMN 280
Cdd:pfam12146 157 YAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLN 235


                  ...
gi 385658043  281 DLE 283
Cdd:pfam12146 236 EPD 238
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
19-297 9.33e-54

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 174.81  E-value: 9.33e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  19 PQPTRVRTADGLELACYRWPSTAPscaaPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAER 98
Cdd:COG2267    3 RRLVTLPTRDGLRLRGRRWRPAGS----PRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  99 FDRYLDDADALVASAARE-NTPLFLMGHSMGGAIAALYaierAAARHASLTGLILSSPALapgrdvpqwmlamsrfisrv 177
Cdd:COG2267   79 FDDYVDDLRAALDALRARpGLPVVLLGHSMGGLIALLY----AARYPDRVAGLVLLAPAY-------------------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 178 wprfpalkidaallsrdpavvaanRADPLVHhgsVPARTGAEIldamrRIAAGRAALRIPVLVYHGTADKLTEPDGSRDF 257
Cdd:COG2267  135 ------------------------RADPLLG---PSARWLRAL-----RLAEALARIDVPVLVLHGGADRVVPPEAARRL 182

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 385658043 258 GAHVgSPDRTLTLYEGNYHETMNDLERERVIGALIDWIAA 297
Cdd:COG2267  183 AARL-SPDVELVLLPGARHELLNEPAREEVLAAILAWLER 221
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 32-299 7.87e-41

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 146.19  E-value: 7.87e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  32 LACYRWpstAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYLDDADALVA 111
Cdd:PLN02652 123 LFCRSW---APAAGEMRGILIIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDGLHGYVPSLDYVVEDTEAFLE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 112 SAAREN--TPLFLMGHSMGGAI---AALYAIERAAarhasLTGLILSSPAL--APGRDVpqwMLAMSRFISRVWPR--FP 182
Cdd:PLN02652 200 KIRSENpgVPCFLFGHSTGGAVvlkAASYPSIEDK-----LEGIVLTSPALrvKPAHPI---VGAVAPIFSLVAPRfqFK 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 183 ALKIDAALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVG 262
Cdd:PLN02652 272 GANKRGIPVSRDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLHGTADRVTDPLASQDLYNEAA 351

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 385658043 263 SPDRTLTLYEGNYHETMNDLERERVIGALIDWIAARV 299
Cdd:PLN02652 352 SRHKDIKLYDGFLHDLLFEPEREEVGRDIIDWMEKRL 388
PHA02857 PHA02857
monoglyceride lipase; Provisional
 28-299 4.42e-37

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 133.09  E-value: 4.42e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  28 DGLELACYRW-PSTAPscaapRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYLDDA 106
Cdd:PHA02857   9 DNDYIYCKYWkPITYP-----KALVFISHGAGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 107 DALVASAARE--NTPLFLMGHSMGGAIAALYAIERAAArhasLTGLILSSPaLAPGRDVPQWMLAMSRFISRVWPRFPAL 184
Cdd:PHA02857  84 VQHVVTIKSTypGVPVFLLGHSMGATISILAAYKNPNL----FTAMILMSP-LVNAEAVPRLNLLAAKLMGIFYPNKIVG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 185 KIDAALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGSp 264
Cdd:PHA02857 159 KLCPESVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC- 237

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 385658043 265 DRTLTLYEGNYHETMNDLE--RERVIGALIDWIAARV 299
Cdd:PHA02857 238 NREIKIYEGAKHHLHKETDevKKSVMKEIETWIFNRV 274
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
51-295 2.97e-35

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 127.37  E-value: 2.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  51 VALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAwAERFDRYLDDADALVASAARENTPLFLMGHSMGGA 130
Cdd:COG1647   18 VLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLL-KTTWEDWLEDVEEAYEILKAGYDKVIVIGLSMGGL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 131 IAAlyaieRAAARHASLTGLILSSPALapgrDVPQWMLAMSRFISRVWPRFPALKIDAAllsrdpavvaaNRADPLVHHG 210
Cdd:COG1647   97 LAL-----LLAARYPDVAGLVLLSPAL----KIDDPSAPLLPLLKYLARSLRGIGSDIE-----------DPEVAEYAYD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 211 SVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGSPDRTLTLYEGNYHETMNDLERERVIGA 290
Cdd:COG1647  157 RTPLRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEE 236


                 ....*
gi 385658043 291 LIDWI 295
Cdd:COG1647  237 ILDFL 241
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 12-302 1.97e-25

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 103.32  E-value: 1.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  12 ADASRAAPQPTRvrtadGLELACYRWPSTAPScaAPRATVALVHGLAEHAG-RYQAFAERLNAAGIEVVAIDLRGHGRSP 90
Cdd:PLN02298  30 IKGSKSFFTSPR-----GLSLFTRSWLPSSSS--PPRALIFMVHGYGNDISwTFQSTAIFLAQMGFACFALDLEGHGRSE 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  91 GERAWAERFDRYLDDA----DALVASAARENTPLFLMGHSMGGAIAALYAIERAAarhaSLTGLILSSPALAPGRDV-PQ 165
Cdd:PLN02298 103 GLRAYVPNVDLVVEDClsffNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPE----GFDGAVLVAPMCKISDKIrPP 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 166 WMLA-MSRFISRVWPRFPALKIdAALLSR---DPAVVAANRADPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVY 241
Cdd:PLN02298 179 WPIPqILTFVARFLPTLAIVPT-ADLLEKsvkVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVL 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 385658043 242 HGTADKLTEPDGSRDFGAHVGSPDRTLTLYEGNYHETM---NDLERERVIGALIDWIAARVPAR 302
Cdd:PLN02298 258 HGSADVVTDPDVSRALYEEAKSEDKTIKIYDGMMHSLLfgePDENIEIVRRDILSWLNERCTGK 321
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 25-296 1.66e-23

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 98.29  E-value: 1.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  25 RTADGLELACYRWpstAPSCAAPRATVALVHGLAEHAGRY-QAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYL 103
Cdd:PLN02385  67 VNSRGVEIFSKSW---LPENSRPKAAVCFCHGYGDTCTFFfEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIPSFDDLV 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 104 DDA----DALVASAARENTPLFLMGHSMGGAIAALYAIERAAArhasLTGLILSSPALAPGRDV-PQW-MLAMSRFISRV 177
Cdd:PLN02385 144 DDViehySKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNA----WDGAILVAPMCKIADDVvPPPlVLQILILLANL 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 178 WPR---FPAlKIDAALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGS 254
Cdd:PLN02385 220 LPKaklVPQ-KDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSVS 298

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 385658043 255 RDFGAHVGSPDRTLTLYEGNYHETMNDLERERVIGALIDWIA 296
Cdd:PLN02385 299 KFLYEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIIS 340
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 20-297 1.94e-20

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 88.05  E-value: 1.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  20 QPTRVRTADGLELACYRWpsTAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGE---RAWA 96
Cdd:COG1073   11 EDVTFKSRDGIKLAGDLY--LPAGASKKYPAVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEGEpreEGSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  97 ERFDrYLDDADALVASAARENTPLFLMGHSMGGAIAALYAIE--RAAArhasltgLILSSPALapgrDVPQWMLA-MSRF 173
Cdd:COG1073   89 ERRD-ARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATdpRVKA-------VILDSPFT----SLEDLAAQrAKEA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 174 ISRVWPRFPALkidaallsrdpavvaanradPLVHHGSVpARTGAEILDAMRRIaagraalRIPVLVYHGTADKLTEPDG 253
Cdd:COG1073  157 RGAYLPGVPYL--------------------PNVRLASL-LNDEFDPLAKIEKI-------SRPLLFIHGEKDEAVPFYM 208

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 385658043 254 SRDFGAHVGSPdRTLTLYEGNYHETMNDLERERVIGALIDWIAA 297
Cdd:COG1073  209 SEDLYEAAAEP-KELLIVPGAGHVDLYDRPEEEYFDKLAEFFKK 251
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 22-298 1.48e-18

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 82.36  E-value: 1.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  22 TRVRTADGLELACYRWPSTAPscaapraTVALVHGLAEHAGRYQAFAERLnAAGIEVVAIDLRGHGRSPGERAwAERFDR 101
Cdd:COG0596    4 PRFVTVDGVRLHYREAGPDGP-------PVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAG-GYTLDD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 102 YLDDADALVASAAREntPLFLMGHSMGGAIAALYAIERAAArhasLTGLILSSPALApgrdvpqwmlamsrfisrvwprf 181
Cdd:COG0596   75 LADDLAALLDALGLE--RVVLVGHSMGGMVALELAARHPER----VAGLVLVDEVLA----------------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 182 palkidaallsRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIaagraalRIPVLVYHGTADKLTEPDGSRDFGAHV 261
Cdd:COG0596  126 -----------ALAEPLRRPGLAPEALAALLRALARTDLRERLARI-------TVPTLVIWGEKDPIVPPALARRLAELL 187

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 385658043 262 gsPDRTLTLYEGNYHETMNDlERERVIGALIDWIAAR 298
Cdd:COG0596  188 --PNAELVVLPGAGHFPPLE-QPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 53-276 2.38e-15

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 74.08  E-value: 2.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   53 LVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAE-RFDRYLDDADALVasAARENTPLFLMGHSMGGAI 131
Cdd:pfam00561   5 LLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDDyRTDDLAEDLEYIL--EALGLEKVNLVGHSMGGLI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  132 AALYAiERAAARHASLTGLILSSPALAPGRDVPQWMLAMSRFISRV------------------WPRFP-ALKIDAALLS 192
Cdd:pfam00561  83 ALAYA-AKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFvadfapnplgrlvakllaLLLLRlRLLKALPLLN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  193 RDPAVVAANRADPLVhHGSVPARTGAEILDAMRRIaagrAALRIPVLVYHGTADKLTEPDGSRDFGAHVgsPDRTLTLYE 272
Cdd:pfam00561 162 KRFPSGDYALAKSLV-TGALLFIETWSTELRAKFL----GRLDEPTLIIWGDQDPLVPPQALEKLAQLF--PNARLVVIP 234


                  ....
gi 385658043  273 GNYH 276
Cdd:pfam00561 235 DAGH 238
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
15-271 9.80e-15

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 72.99  E-value: 9.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  15 SRAAPQPTRVRTADGLELACYRWPSTAPscaaPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRS-PGE- 92
Cdd:COG4757    3 TAASPESVTITAADGYPLAARLFPPAGP----PRAVVLINPATGVPQRFYRPFARYLAERGFAVLTYDYRGIGLSrPGSl 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  93 -------RAWAERfdryldDADALVASAARE--NTPLFLMGHSMGGAIAALYAIERAAARH---ASLTGLILSSPALAPG 160
Cdd:COG4757   79 rgfdagyRDWGEL------DLPAVLDALRARfpGLPLLLVGHSLGGQLLGLAPNAERVDRLvtvASGSGYWRDYPPRRRL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 161 RDVPQWMLAMsRFISRVWPRFPALKIdaALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMrriaagrAALRIPVLV 240
Cdd:COG4757  153 KVLLFWHLLG-PLLTRLLGYFPGRRL--GFGEDLPAGVARQWRRWCRRPRYFFDDDGEDLEAAL-------AAVTAPVLA 222

                        250       260       270
                 ....*....|....*....|....*....|.
gi 385658043 241 YHGTADKLTEPDGSRDFGAHVGSPDRTLTLY 271
Cdd:COG4757  223 ISFTDDELAPPAAVDRLLAYYPNAPVTRRRL 253
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
23-300 1.54e-13

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 68.50  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  23 RVRTADGLELACYRwpsTAPSCAAPRATVALVHGLAEHA-GRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDr 101
Cdd:COG1506    1 TFKSADGTTLPGWL---YLPADGKKYPVVVYVHGGPGSRdDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDD- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 102 YLDDADALVASAARENTPLFLMGHSMGGAIAAlyaieRAAARHASL-TGLILSSPALapgrDVPQWMLAMSRFisRVWPR 180
Cdd:COG1506   77 VLAAIDYLAARPYVDPDRIGIYGHSYGGYMAL-----LAAARHPDRfKAAVALAGVS----DLRSYYGTTREY--TERLM 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 181 FPALKIDAALLSRDPAVVAANradplvhhgsvpartgaeildamrriaagraaLRIPVLVYHGTADKLTEPDGSRDF--G 258
Cdd:COG1506  146 GGPWEDPEAYAARSPLAYADK--------------------------------LKTPLLLIHGEADDRVPPEQAERLyeA 193

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 385658043 259 AHVGSPDRTLTLYEGNYHEtMNDLERERVIGALIDWIAARVP 300
Cdd:COG1506  194 LKKAGKPVELLVYPGEGHG-FSGAGAPDYLERILDFLDRHLK 234
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 45-150 5.73e-10

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 55.61  E-value: 5.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  45 AAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAwaERFDRYLDDADAlvasaARENTPLFLMG 124
Cdd:COG1075    2 AATRYPVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNGSIEDSA--EQLAAFVDAVLA-----ATGAEKVDLVG 74

                         90       100
                 ....*....|....*....|....*..
gi 385658043 125 HSMGGAIAALYAIERAAARH-ASLTGL 150
Cdd:COG1075   75 HSMGGLVARYYLKRLGGAAKvARVVTL 101
GrsT COG3208
Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and ...
 64-297 1.14e-09

Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442441 [Multi-domain]  Cd Length: 237  Bit Score: 57.55  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  64 YQAFAERLnAAGIEVVAIDLRGHGRSPGERAwaerfdryLDDADALVASAARE-----NTPLFLMGHSMGGAIAALYAIE 138
Cdd:COG3208   22 YRPWAAAL-PPDIEVLAVQLPGRGDRLGEPP--------LTSLEELADDLAEElapllDRPFALFGHSMGALLAFELARR 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 139 RAAARHASLTGLILSSpALAPGR-DVPQWMLAMSrfisrvwprfpalkiDAALLSRdpavvaanradpLVHHGSVPARTG 217
Cdd:COG3208   93 LERRGRPLPAHLFVSG-RRAPHLpRRRRPLHDLS---------------DAELLAE------------LRRLGGTPEEVL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 218 AE------ILDAMR---RIAAG-----RAALRIPVLVYHGTADKLTEPDGSRDFGAHVGSPDRtLTLYEGN--YHETmnd 281
Cdd:COG3208  145 ADpellelFLPILRadfRLLETyrytpGPPLDCPITALGGDDDPLVSPEELAAWREHTTGPFR-LRVFPGGhfFLRD--- 220

                        250
                 ....*....|....*.
gi 385658043 282 lERERVIGALIDWIAA 297
Cdd:COG3208  221 -HPAELLALIRAALAA 235
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
20-143 1.58e-09

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 56.90  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  20 QPTRVRTADGLELACYRWpstAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGE----RAW 95
Cdd:COG0412    4 ETVTIPTPDGVTLPGYLA---RPAGGGPRPGVVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLYGRGGPGDDpdeaRAL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 385658043  96 AERFD--RYLDDADALVASAARE----NTPLFLMGHSMGGAIAALYAIERAAAR 143
Cdd:COG0412   81 MGALDpeLLAADLRAALDWLKAQpevdAGRVGVVGFCFGGGLALLAAARGPDLA 134
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 47-142 1.21e-08

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 53.75  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   47 PRATVALVHGlaehAGR------YQAFAERLNAAGIEVVAID-------LRGHGRSPgerawAERFDRYLDDADALVASA 113
Cdd:pfam20408   1 PKARLLLAHG----AGAgmdspfMQAMAAALAARGIAVVRFNfpymqrrRRTGKRRP-----PDRAPKLLEAFRAVIAAL 71

                          90       100
                  ....*....|....*....|....*....
gi 385658043  114 ARENTPLFLMGHSMGGAIAALYAIERAAA 142
Cdd:pfam20408  72 RGPDLPLFIGGKSMGGRVASLLADDSGVK 100
PRK10749 PRK10749
lysophospholipase L2; Provisional
 75-155 3.04e-08

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 54.23  E-value: 3.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  75 GIEVVAIDLRGHGRS-----PGERAWAERFDRYLDDADALVAS--AARENTPLFLMGHSMGGAIAALY-----AIERAAA 142
Cdd:PRK10749  81 GYDVLIIDHRGQGRSgrlldDPHRGHVERFNDYVDDLAAFWQQeiQPGPYRKRYALAHSMGGAILTLFlqrhpGVFDAIA 160

                         90
                 ....*....|...
gi 385658043 143 RHASLTGLILSSP 155
Cdd:PRK10749 161 LCAPMFGIVLPLP 173
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 4-156 4.22e-08

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 53.79  E-value: 4.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   4 AAPTSPRSADASRAAPQPTRVRTADGLelacYRWPSTAPSCAAPratVALVHGLAEHAGRYQAFAERLnAAGIEVVAIDL 83
Cdd:PRK14875  94 ARRFAPEGIDEEDAGPAPRKARIGGRT----VRYLRLGEGDGTP---VVLIHGFGGDLNNWLFNHAAL-AAGRPVIALDL 165

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 385658043  84 RGHGRSpGERAWAERFDrylDDADALVAS-AARENTPLFLMGHSMGGAIAALYAiERAAARHASLTgliLSSPA 156
Cdd:PRK14875 166 PGHGAS-SKAVGAGSLD---ELAAAVLAFlDALGIERAHLVGHSMGGAVALRLA-ARAPQRVASLT---LIAPA 231
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
64-157 4.43e-08

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 52.47  E-value: 4.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  64 YQAFAERLNAAGIEVVAIDLRGHGRSPGErawaerFDR---YLDDADALVASAAREN-TPLFLMGHSMGGAIAAlyaieR 139
Cdd:COG2945   44 VYTLARALVAAGFAVLRFNFRGVGRSEGE------FDEgrgELDDAAAALDWLRAQNpLPLWLAGFSFGAYVAL-----Q 112

                         90
                 ....*....|....*...
gi 385658043 140 AAARHASLTGLILSSPAL 157
Cdd:COG2945  113 LAMRLPEVEGLILVAPPV 130
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
45-161 2.05e-07

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 50.26  E-value: 2.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  45 AAPRATVALVHGLAehAGR----YQAFAERLNAAGIEVVAIDL--RGHGRSPGERAwaerfdRYLDDADALVASAARE-- 116
Cdd:COG3571    6 EDPRATLLLAHGAG--AGMdspfMVALAEALAAAGIAVARFEFpyMVAGRRPPDRA------PVLDAAWRAVIAALRArl 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 385658043 117 -NTPLFLMGHSMGGAIAALYAIERAAARhasltGLI-LSSPALAPGR 161
Cdd:COG3571   78 aGLPLVIGGKSMGGRVASMLAAEGGGAA-----GLVcLGYPFHPPGK 119
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 53-200 3.17e-07

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 50.16  E-value: 3.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   53 LVHGLAEHAGRYQAfaerLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYLDDADALVASAarentPLFLMGHSMGGAIA 132
Cdd:pfam12697   3 LVHGAGLSAAPLAA----LLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAAR-----PVVLVGHSLGGAVA 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 385658043  133 AlyaierAAARHASLTGLILSSPALAPGRDVPQWMLAMSRFISRVWPRFPALKIDAALLSRDPAVVAA 200
Cdd:pfam12697  74 L------AAAAAALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAE 135
PRK05855 PRK05855
SDR family oxidoreductase;
22-157 6.86e-07

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 50.36  E-value: 6.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  22 TRVRTADGLELACYRWpsTAPScaapRATVALVHGLAEHAGRYQAFAERLnAAGIEVVAIDLRGHGRS--PGERAwAERF 99
Cdd:PRK05855   5 RTVVSSDGVRLAVYEW--GDPD----RPTVVLVHGYPDNHEVWDGVAPLL-ADRFRVVAYDVRGAGRSsaPKRTA-AYTL 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 100 DRYLDDADAlVASAARENTPLFLMGHSMgGAIAALYAI--ERAAARHASLTGliLSSPAL 157
Cdd:PRK05855  77 ARLADDFAA-VIDAVSPDRPVHLLAHDW-GSIQGWEAVtrPRAAGRIASFTS--VSGPSL 132
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 42-141 1.23e-05

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 45.96  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   42 PSCAAPRATVALVHGLAE--HAGRYQAF--AERLNAAGIEVVAIDLRGHGRSPGERAwAERFDRYLDDadalVASAAR-- 115
Cdd:TIGR03101  19 PVAVGPRGVVIYLPPFAEemNKSRRMVAlqARAFAAGGFGVLQIDLYGCGDSAGDFA-AARWDVWKED----VAAAYRwl 93

                          90       100
                  ....*....|....*....|....*....
gi 385658043  116 ---ENTPLFLMGHSMGGAIAALYAIERAA 141
Cdd:TIGR03101  94 ieqGHPPVTLWGLRLGALLALDAANPLAA 122
YpfH COG0400
Predicted esterase [General function prediction only];
45-159 3.69e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 40.66  E-value: 3.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  45 AAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAidLRG-HGRSPGERAW-----------AERFDRYLDDADALVAS 112
Cdd:COG0400    2 GPAAPLVVLLHGYGGDEEDLLPLAPELALPGAAVLA--PRApVPEGPGGRAWfdlsflegredEEGLAAAAEALAAFIDE 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 385658043 113 AARE----NTPLFLMGHSMGGAIAALYAIERAAArhasLTGLILSSPALAP 159
Cdd:COG0400   80 LEARygidPERIVLAGFSQGAAMALSLALRRPEL----LAGVVALSGYLPG 126
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 55-152 3.89e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 40.98  E-value: 3.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  55 HGLAEHAGRYQAFAERLnaAGIEVVAIDLRGHGRSPGERAwaERFDryldDADALVAS--AARENTPLFLMGHSMGGAIA 132
Cdd:PRK11126   9 HGLLGSGQDWQPVGEAL--PDYPRLYIDLPGHGGSAAISV--DGFA----DVSRLLSQtlQSYNILPYWLVGYSLGGRIA 80

                         90       100
                 ....*....|....*....|
gi 385658043 133 ALYAIEraaARHASLTGLIL 152
Cdd:PRK11126  81 MYYACQ---GLAGGLCGLIV 97
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 52-158 8.34e-04

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 40.56  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  52 ALVHGLAEHAGRYQAFaERLN--AAGIEVVAIDLRGHGRSPGERAWAERFD---------RYLDDADALV---------- 110
Cdd:COG3458   84 AVVEFHGYGGGRGLPH-EDLDwaAAGYAVLVMDTRGQGSSWGDTPDPGGYSggalpgymtRGIDDPDTYYyrrvyldavr 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 385658043 111 -ASAARENTP-----LFLMGHSMGGAIAALyaierAAARHASLTGLILSSPALA 158
Cdd:COG3458  163 aVDALRSLPEvdgkrIGVTGGSQGGGLALA-----AAALDPRVKAAAADVPFLC 211
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
3-282 3.04e-03

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 38.55  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043   3 AAAPTSPRSADASRAAPQPTRVRTADG---LELACYrWPSTAPSCAAPRATVALV---HGLAEHAGRYQAFAERLNAAGI 76
Cdd:COG4188   12 AAAASPLRQPGPFAVGVQTLTLRDPSRdrpLPVDVW-YPATAPADAPAGGPFPLVvlsHGLGGSREGYAYLAEHLASHGY 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043  77 EVVAIDLRGHGRS---------PGERAWAERFDRYLDDADALVASAARENTPLFL-----------MGHSMGGAIAALya 136
Cdd:COG4188   91 VVAAPDHPGSNAAdlsaaldglADALDPEELWERPLDLSFVLDQLLALNKSDPPLagrldldrigvIGHSLGGYTALA-- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385658043 137 ieraaarhasLTGLILSSPALAPGRDVPQWMLAMSRFISRVWPRFpalkidaallsRDPAVVAANRADPlvhhgsvparT 216
Cdd:COG4188  169 ----------LAGARLDFAALRQYCGKNPDLQCRALDLPRLAYDL-----------RDPRIKAVVALAP----------G 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 385658043 217 GAEILDamrriAAGRAALRIPVLVYHGTADKLT-EPDGSRDFGAHVGSPDRTLTLYEGNYHETMNDL 282
Cdd:COG4188  218 GSGLFG-----EEGLAAITIPVLLVAGSADDVTpAPDEQIRPFDLLPGADKYLLTLEGATHFSFLDP 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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