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Conserved domains on  [gi|342352301|gb|AEL24831|]
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regulatory protein ArsR [Cyclobacterium marinum DSM 745]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 12-90 2.32e-19

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 75.96  E-value: 2.32e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 342352301  12 MRVFKALSEEARVRILHLLMQnEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFYYVldeAHEILNQIL 90
Cdd:NF033788   2 AELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRL---ADEHVAELL 76
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 12-90 2.32e-19

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 75.96  E-value: 2.32e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 342352301  12 MRVFKALSEEARVRILHLLMQnEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFYYVldeAHEILNQIL 90
Cdd:NF033788   2 AELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRL---ADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
13-93 6.95e-19

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 74.93  E-value: 6.95e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342352301  13 RVFKALSEEARVRILHLLMQnEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFYYVLDEA-HEILNQILK 91
Cdd:COG0640   12 ELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAlAELLEWLLE 90


                 ..
gi 342352301  92 FI 93
Cdd:COG0640   91 LL 92
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 12-76 5.81e-13

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 60.60  E-value: 5.81e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342352301  12 MRVFKALSEEARVRILHLLMQNEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFY 76
Cdd:PRK10141   7 LQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHY 71
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 15-89 4.00e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 57.31  E-value: 4.00e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342352301  15 FKALSEEARVRILHLLMQNEeLCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTfYYVLDEAHEILNQI 89
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRV-YYSLTDAERLLALL 73
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-81 3.12e-09

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 49.52  E-value: 3.12e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 342352301    25 RILHLLMqNEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFYYVLDE 81
Cdd:smart00418   1 KILKLLA-EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 21-65 3.31e-07

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 43.97  E-value: 3.31e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 342352301   21 EARVRILHLLMQNEeLCISDLEHILEFTQTKTSRHVTYLKNAGLI 65
Cdd:pfam01022   2 PTRLKILKLLAEGE-LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 12-90 2.32e-19

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 75.96  E-value: 2.32e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 342352301  12 MRVFKALSEEARVRILHLLMQnEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFYYVldeAHEILNQIL 90
Cdd:NF033788   2 AELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRL---ADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
13-93 6.95e-19

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 74.93  E-value: 6.95e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342352301  13 RVFKALSEEARVRILHLLMQnEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFYYVLDEA-HEILNQILK 91
Cdd:COG0640   12 ELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAlAELLEWLLE 90


                 ..
gi 342352301  92 FI 93
Cdd:COG0640   91 LL 92
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 12-76 5.81e-13

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 60.60  E-value: 5.81e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342352301  12 MRVFKALSEEARVRILHLLMQNEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFY 76
Cdd:PRK10141   7 LQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHY 71
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 15-89 4.00e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 57.31  E-value: 4.00e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342352301  15 FKALSEEARVRILHLLMQNEeLCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTfYYVLDEAHEILNQI 89
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRV-YYSLTDAERLLALL 73
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-81 3.12e-09

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 49.52  E-value: 3.12e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 342352301    25 RILHLLMqNEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFYYVLDE 81
Cdd:smart00418   1 KILKLLA-EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE 56
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
12-70 1.93e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 45.72  E-value: 1.93e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 342352301  12 MRVFKALSEEARVRILHLLmQNEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKK 70
Cdd:COG4189   10 LEVLKALASETRLRILRLL-AEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 21-65 3.31e-07

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 43.97  E-value: 3.31e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 342352301   21 EARVRILHLLMQNEeLCISDLEHILEFTQTKTSRHVTYLKNAGLI 65
Cdd:pfam01022   2 PTRLKILKLLAEGE-LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 13-69 4.67e-07

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 43.68  E-value: 4.67e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 342352301   13 RVFKALSEEARVRILHLLMQNEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRK 69
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
12-82 8.51e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.17  E-value: 8.51e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 342352301  12 MRVFKALSEEARVRILHLLMQNEELCISDLEHILEFTQTKTSRHVTYLKNAGLIGSRKKDQWTFYYVLDEA 82
Cdd:COG3398   88 KKILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPE 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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