|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
3-394 |
5.97e-147 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 422.58 E-value: 5.97e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 3 LTTVTEATRIILENSLDYGTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQSYLN-GQRDFRIESTQTAGET 81
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGaNPVTLRVVGEIAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 82 QHTLSDPNACIEVMTGAALPINTDLVIRYEDLDIKDGVAHLTATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAA 161
Cdd:COG0303 81 PPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 162 GIGASQVAVRRLPSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHV-DFVHIPDELSATQRAIEQALTQYE 240
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVvDLGIVPDDPEALRAALREALAEAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 241 VLILCGGVSQGKKDFIPQALQAEGVEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCARRYFIPWLRRSLGLRA 320
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 336304352 321 MDN--IYAALSDDYVYNSPLTYFLQVQLFQEGATLMARPLVGHGSGDFANLIDNQGFLEIPQERNEFKKGEILPIW 394
Cdd:COG0303 321 PPPprVRARLAEDLPKKPGRTEFLRVRLERDDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVL 396
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
6-396 |
2.96e-139 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 402.64 E-value: 2.96e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 6 VTEATRIILENSLDYGTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQSYLNGQRDFRIESTQTAGETQHTL 85
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASVTLRVVGEIPAGEPPDGP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 86 SDPNACIEVMTGAALPINTDLVIRYEDLDIKDGVAHLTATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAAGIGA 165
Cdd:cd00887 81 LGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 166 SQVAVRRLPSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHV-DFVHIPDELSATQRAIEQALTQYEVLIL 244
Cdd:cd00887 161 AEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVvDLGIVPDDPEALREALEEALEEADVVIT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 245 CGGVSQGKKDFIPQALQAEGVEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCARRYFIPWLRRSLGLRAMDN- 323
Cdd:cd00887 241 SGGVSVGDYDFVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPp 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 336304352 324 -IYAALSDDYVYNSPLTYFLQVQLFQEGATLMARPLVGHGSGDFANLIDNQGFLEIPQERNEFKKGEILPIWQY 396
Cdd:cd00887 321 rVKARLAEDLKSKPGRREFLRVRLERDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
2-389 |
7.17e-70 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 231.26 E-value: 7.17e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 2 ELTTVTEATRIILE--NSLDYGTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIqwqsylngqrdfRIESTQTAG 79
Cdd:PRK14498 8 TLVSLEEAREILESllSELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAV------------RAADTFGAS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 80 ETQH-TLS---------------DPNACIEVMTGAALPINTDLVIRYEDLDIKD-GVAHLTATVRKGQNVHYQGEDRRAG 142
Cdd:PRK14498 76 EANPvRLKlggevhageapdvevEPGEAVEIATGAPIPRGADAVVMVEDTEEVDdDTVEIYRPVAPGENVRPAGEDIVAG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 143 APIVQPYTLLGPPEIAIAAGIGASQVAVRRLPSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHVDFV-HI 221
Cdd:PRK14498 156 ELILPKGTRLTPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYgIV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 222 PDELSATQRAIEQALTQYEVLILCGGVSQGKKDFIPQALQAEGvEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSF 301
Cdd:PRK14498 236 PDDEEELEAALRKALKECDLVLLSGGTSAGAGDVTYRVIEELG-EVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 302 LCARRYFIPWLRRSLGLRAMDN--IYAALSddYVYNSPL--TYFLQVQLFQEGATLMARPlVGHGSGDFANLIDNQGFLE 377
Cdd:PRK14498 315 TIFEEFVAPLLRKLAGLPPPERatVKARLA--RRVRSELgrEEFVPVSLGRVGDGYVAYP-LSRGSGAITSLVRADGFIE 391
|
410
....*....|..
gi 336304352 378 IPQERNEFKKGE 389
Cdd:PRK14498 392 IPANTEGLEAGE 403
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
21-164 |
2.80e-37 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 132.31 E-value: 2.80e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 21 GTEYVPFTS--AYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQSYlngqRDFRIESTQTAGETQHTLSDPNACIEVMTGA 98
Cdd:pfam03453 5 TEETVPLEAldALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADG----FGASEVNPIAAGEPPGPLLPGGEAVRIMTGA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 336304352 99 ALPINTDLVIRYEDLDIKDGVAHL-TATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAAGIG 164
Cdd:pfam03453 81 PLPEGADAVVMVEDTEEGGGRTVEiRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
174-310 |
1.50e-29 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 111.64 E-value: 1.50e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 174 PSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHVDFV-HIPDELSATQRAIEQALTQYEVLILCGGVSQGK 252
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLgIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 336304352 253 KDFIPQALQA------EGVEKYFHK----VSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCARRYFIP 310
Cdd:TIGR00177 81 RDVTPEALEElgekeiPGFGEFRMLsslpVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
178-303 |
6.15e-25 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 98.82 E-value: 6.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 178 IITSGDELVPveqtplPHQIRSSNVHCIASLLKEYRLHVDFVHI---PDELSATQRAIEQALTQYEVLILCGGVSQGKKD 254
Cdd:smart00852 2 IISTGDELLS------GGQIRDSNGPMLAALLRELGIEVVRVVVvggPDDPEAIREALREALAEADVVITTGGTGPGPDD 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 336304352 255 FIPQAL-QAEGVEKYFHKVSQQPGKPF-----WFGR----KGNRVVFALPGNPVSSFLC 303
Cdd:smart00852 76 LTPEALaELGGRELLGHGVAMRPGGPPgplanLSGTapgvRGKKPVFGLPGNPVAALVM 134
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
3-394 |
5.97e-147 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 422.58 E-value: 5.97e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 3 LTTVTEATRIILENSLDYGTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQSYLN-GQRDFRIESTQTAGET 81
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGaNPVTLRVVGEIAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 82 QHTLSDPNACIEVMTGAALPINTDLVIRYEDLDIKDGVAHLTATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAA 161
Cdd:COG0303 81 PPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 162 GIGASQVAVRRLPSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHV-DFVHIPDELSATQRAIEQALTQYE 240
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVvDLGIVPDDPEALRAALREALAEAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 241 VLILCGGVSQGKKDFIPQALQAEGVEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCARRYFIPWLRRSLGLRA 320
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 336304352 321 MDN--IYAALSDDYVYNSPLTYFLQVQLFQEGATLMARPLVGHGSGDFANLIDNQGFLEIPQERNEFKKGEILPIW 394
Cdd:COG0303 321 PPPprVRARLAEDLPKKPGRTEFLRVRLERDDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVL 396
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
6-396 |
2.96e-139 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 402.64 E-value: 2.96e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 6 VTEATRIILENSLDYGTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQSYLNGQRDFRIESTQTAGETQHTL 85
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASVTLRVVGEIPAGEPPDGP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 86 SDPNACIEVMTGAALPINTDLVIRYEDLDIKDGVAHLTATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAAGIGA 165
Cdd:cd00887 81 LGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 166 SQVAVRRLPSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHV-DFVHIPDELSATQRAIEQALTQYEVLIL 244
Cdd:cd00887 161 AEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVvDLGIVPDDPEALREALEEALEEADVVIT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 245 CGGVSQGKKDFIPQALQAEGVEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCARRYFIPWLRRSLGLRAMDN- 323
Cdd:cd00887 241 SGGVSVGDYDFVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPp 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 336304352 324 -IYAALSDDYVYNSPLTYFLQVQLFQEGATLMARPLVGHGSGDFANLIDNQGFLEIPQERNEFKKGEILPIWQY 396
Cdd:cd00887 321 rVKARLAEDLKSKPGRREFLRVRLERDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
2-389 |
7.17e-70 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 231.26 E-value: 7.17e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 2 ELTTVTEATRIILE--NSLDYGTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIqwqsylngqrdfRIESTQTAG 79
Cdd:PRK14498 8 TLVSLEEAREILESllSELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAV------------RAADTFGAS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 80 ETQH-TLS---------------DPNACIEVMTGAALPINTDLVIRYEDLDIKD-GVAHLTATVRKGQNVHYQGEDRRAG 142
Cdd:PRK14498 76 EANPvRLKlggevhageapdvevEPGEAVEIATGAPIPRGADAVVMVEDTEEVDdDTVEIYRPVAPGENVRPAGEDIVAG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 143 APIVQPYTLLGPPEIAIAAGIGASQVAVRRLPSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHVDFV-HI 221
Cdd:PRK14498 156 ELILPKGTRLTPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYgIV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 222 PDELSATQRAIEQALTQYEVLILCGGVSQGKKDFIPQALQAEGvEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSF 301
Cdd:PRK14498 236 PDDEEELEAALRKALKECDLVLLSGGTSAGAGDVTYRVIEELG-EVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 302 LCARRYFIPWLRRSLGLRAMDN--IYAALSddYVYNSPL--TYFLQVQLFQEGATLMARPlVGHGSGDFANLIDNQGFLE 377
Cdd:PRK14498 315 TIFEEFVAPLLRKLAGLPPPERatVKARLA--RRVRSELgrEEFVPVSLGRVGDGYVAYP-LSRGSGAITSLVRADGFIE 391
|
410
....*....|..
gi 336304352 378 IPQERNEFKKGE 389
Cdd:PRK14498 392 IPANTEGLEAGE 403
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
2-300 |
8.84e-47 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 168.06 E-value: 8.84e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 2 ELTTVTEATRIILeNSLDY--GTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQwQSYLNGQrdFRIESTQTAG 79
Cdd:PRK14497 9 SLYSIDEAIKVFL-SSLNFkpKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALK-SSCTPGE--FKVIDKIGIG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 80 ETQHTLSDPNACIEVMTGAALPINTDLVIRYEDLDIKDG-VAHLTATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIA 158
Cdd:PRK14497 85 EFKEIHIKECEAVEVDTGSMIPMGADAVIKVENTKVINGnFIKIDKKINFGQNIGWIGSDIPKGSIILRKGEVISHEKIG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 159 IAAGIGASQVAVRRLPSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKE--YRLhVDFVHIPDELSATQRAIEQAL 236
Cdd:PRK14497 165 LLASLGISSVKVYEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSegYKI-VGLSLLSDDKESIKNEIKRAI 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 336304352 237 TQYEVLILCGGVSQGKKDFIPQALQAEGvEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSS 300
Cdd:PRK14497 244 SVADVLILTGGTSAGEKDFVHQAIRELG-NIIVHGLKIKPGKPTILGIVDGKPVIGLPGNIVST 306
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
21-314 |
2.24e-46 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 167.87 E-value: 2.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 21 GTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQsylngqrDFRIESTQTAGET------QHTLSDPNAcIEV 94
Cdd:PRK14491 217 ETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSD-------DLEPESYTLVGEVlaghqyDGTLQAGEA-VRI 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 95 MTGAALPINTDLVIRYEDLDIKDGVAHLTATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAAGIGASQVAVRRLP 174
Cdd:PRK14491 289 MTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLASLGFAEVPVFRRP 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 175 SVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHV-DFVHIPDELSATQRAIEQALTQYEVLILCGGVSQGKK 253
Cdd:PRK14491 369 KVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEViDLGIIEDSEAALEATLEQAAAQADVVISSGGVSVGDA 448
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 336304352 254 DFIPQALQAEGvEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCARRYFIPWLRR 314
Cdd:PRK14491 449 DYIKTALAKLG-QIDFWRINMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQFVEPALRK 508
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
22-320 |
4.96e-46 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 162.95 E-value: 4.96e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 22 TEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQSyLNGQRDFRIESTQTAGETQHTLSDPNACIEVMTGAALP 101
Cdd:PRK10680 27 TETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLAD-LASGQPLPVAGKAFAGQPFHGEWPAGTCIRIMTGAPVP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 102 INTDLVIRYEDLDIKDGVAHLTATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAAGIGASQVAVRRLPSVVIITS 181
Cdd:PRK10680 106 EGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGTRLTTAELPVLASLGIAEVPVVRKVRVALFST 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 182 GDELVPVEQtPLPH-QIRSSNVHCIASLLKEYRLHV-DFVHIPDELSATQRAIEQALTQYEVLILCGGVSQGKKDFIPQA 259
Cdd:PRK10680 186 GDELQLPGQ-PLGDgQIYDTNRLAVHLMLEQLGCEViNLGIIRDDPHALRAAFIEADSQADVVISSGGVSVGEADYTKTI 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 336304352 260 LQAEGvEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCARRYFIPWLRRSLGLRA 320
Cdd:PRK10680 265 LEELG-EIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAKLSGNTA 324
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
21-164 |
2.80e-37 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 132.31 E-value: 2.80e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 21 GTEYVPFTS--AYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQSYlngqRDFRIESTQTAGETQHTLSDPNACIEVMTGA 98
Cdd:pfam03453 5 TEETVPLEAldALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADG----FGASEVNPIAAGEPPGPLLPGGEAVRIMTGA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 336304352 99 ALPINTDLVIRYEDLDIKDGVAHL-TATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAAGIG 164
Cdd:pfam03453 81 PLPEGADAVVMVEDTEEGGGRTVEiRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
21-304 |
6.60e-37 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 138.90 E-value: 6.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 21 GTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQSYLNGQRDFRIESTQTAGETQHTLSDPNACIEVMTGAAL 100
Cdd:PRK14690 41 DIKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGFAGAAPEGAQVLPLIEGRAAAGVPFSGRVPEGMALRILTGAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 101 PINTDLVIRYEDLDIKDGVAHLTATVRKGQNVHYQGEDRRAGAPIVQPYTLLGPPEIAIAAGIGASQVAVRRLPSVVIIT 180
Cdd:PRK14690 121 PEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLALLSAVGLTRVSVRRPLRVAVLS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 181 SGDELVPVEQTPLPHQIRSSNVHCIASLLKEY-RLHVDFVHIPDELSATQRAIEQALTQYEVLILCGGVSQGKKDFIPQA 259
Cdd:PRK14690 201 TGDELVEPGALAEVGQIYDANRPMLLALARRWgHAPVDLGRVGDDRAALAARLDRAAAEADVILTSGGASAGDEDHVSAL 280
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 336304352 260 LQAEGVEKYFhKVSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCA 304
Cdd:PRK14690 281 LREAGAMQSW-RIALKPGRPLALGLWQGVPVFGLPGNPVAALVCT 324
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
2-313 |
7.53e-35 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 136.10 E-value: 7.53e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 2 ELTTVTEATRIILENSLDYGTEYVPFTSAYQRVLAEPLVADRDFPPFDRVTMDGIAIQWQsylNGQRDFRIESTQTAGE- 80
Cdd:PLN02699 6 EMISVEEALSIVLSVAARLSPVIVPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVAS---DGPGEYPVITESRAGNd 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 81 -TQHTLSdPNACIEVMTGAALPINTDLVIRYEDLDIKDGVAHLTATVR------KGQNVHYQGEDRRAGAPIVQPYTLLG 153
Cdd:PLN02699 83 gLGVTLT-PGTVAYVTTGGPIPDGADAVVQVEDTEVVEDPLDGSKRVRilsqasKGQDIRPVGCDIEKDAKVLKAGERLG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 154 PPEIAIAAGIGASQVAVRRLPSVVIITSGDELV-PVEQTPLPHQIRSSNVhciASLLKEYRLH----VDFVHIPDELSAT 228
Cdd:PLN02699 162 ASEIGLLATVGVTMVKVYPRPTVAILSTGDELVePTTGTLGRGQIRDSNR---AMLLAAAIQQqckvVDLGIARDDEEEL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 229 QRAIEQALTQ-YEVLILCGGVSQGKKDFIPQALQAEGvEKYFHKVSQQPGKPFWF---------GRKGNRVVFALPGNPV 298
Cdd:PLN02699 239 ERILDEAISSgVDILLTSGGVSMGDRDFVKPLLEKRG-TVYFSKVLMKPGKPLTFaeidaksapSNSKKMLAFGLPGNPV 317
|
330
....*....|....*
gi 336304352 299 SSFLCARRYFIPWLR 313
Cdd:PLN02699 318 SCLVCFNLFVVPAIR 332
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
174-310 |
1.50e-29 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 111.64 E-value: 1.50e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 174 PSVVIITSGDELVPVEQTPLPHQIRSSNVHCIASLLKEYRLHVDFV-HIPDELSATQRAIEQALTQYEVLILCGGVSQGK 252
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLgIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 336304352 253 KDFIPQALQA------EGVEKYFHK----VSQQPGKPFWFGRKGNRVVFALPGNPVSSFLCARRYFIP 310
Cdd:TIGR00177 81 RDVTPEALEElgekeiPGFGEFRMLsslpVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
178-314 |
3.21e-26 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 102.71 E-value: 3.21e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 178 IITSGDELvpveqtpLPHQIRSSNVHCIASLLKEYRLHVDFV-HIPDELSATQRAIEQALTQYEVLILCGGVSQGKKDFI 256
Cdd:pfam00994 2 IITTGDEL-------LPGQIRDTNGPLLAALLREAGAEVIRYgIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDVT 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 336304352 257 PQAL------QAEGVEKYFHKVSQQPGKPFWFGR-----KGNRVVFALPGNPVSSFLCARRYFIPWLRR 314
Cdd:pfam00994 75 PEALaelggrELPGFEELFRGVSLKPGKPVGTAPgailsRAGKTVFGLPGSPVAAKVMFELLLLPLLRH 143
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
178-303 |
6.15e-25 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 98.82 E-value: 6.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 178 IITSGDELVPveqtplPHQIRSSNVHCIASLLKEYRLHVDFVHI---PDELSATQRAIEQALTQYEVLILCGGVSQGKKD 254
Cdd:smart00852 2 IISTGDELLS------GGQIRDSNGPMLAALLRELGIEVVRVVVvggPDDPEAIREALREALAEADVVITTGGTGPGPDD 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 336304352 255 FIPQAL-QAEGVEKYFHKVSQQPGKPF-----WFGR----KGNRVVFALPGNPVSSFLC 303
Cdd:smart00852 76 LTPEALaELGGRELLGHGVAMRPGGPPgplanLSGTapgvRGKKPVFGLPGNPVAALVM 134
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
176-303 |
3.38e-17 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 77.38 E-value: 3.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 176 VVIITSGDELVPVeqtplphQIRSSNVHCIASLLKEYRLHVDFVHI-PDELSATQRAIEQALTQYEVLILCGGVSQGKKD 254
Cdd:cd00758 2 VAIVTVSDELSQG-------QIEDTNGPALEALLEDLGCEVIYAGVvPDDADSIRAALIEASREADLVLTTGGTGVGRRD 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 336304352 255 FIPQALQAEG-VEKYFHKVSQQPGKPFWFGRKGNRVVFALPGNPVSSFLC 303
Cdd:cd00758 75 VTPEALAELGeREAHGKGVALAPGSRTAFGIIGKVLIINLPGSPKSALTT 124
|
|
| MoeA_like |
cd03522 |
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ... |
158-305 |
3.54e-07 |
|
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.
Pssm-ID: 239599 Cd Length: 312 Bit Score: 51.39 E-value: 3.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 158 AIAAGIGASQVAVRRLPSVVIITSGDElvpVEQTPLphQIRSSNVhcIASLLKEYRLHVDFVHI-PDELSATQRAIEQAL 236
Cdd:cd03522 144 ALARDGPLLRVAPFRPLRVGLIVTGSE---VYGGRI--EDKFGPV--LRARLAALGVELVEQVIvPHDEAAIAAAIAEAL 216
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336304352 237 TQYEVLILC-GGVSQGKKDFIPQALQAEGVEKYFHKVSQQPGKPFWFGRKGNRVVFALPGnpvssflCAR 305
Cdd:cd03522 217 EAGAELLILtGGASVDPDDVTPAAIRAAGGEVIRYGMPVDPGNLLLLGYLGGVPVIGLPG-------CAR 279
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
326-396 |
6.56e-06 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 43.75 E-value: 6.56e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 336304352 326 AALSDDYVYNSPLTYFLQVQLFQEGATLMARPLVGHGSGDFANLIDNQGFLEIPQERNEFKKGEILPIWQY 396
Cdd:pfam03454 2 ARLARDLKSDPGRREFVRVRLHEEDGRYYAEPIGKQGSGMLSSLAEANGLIVVPEGTEGLEAGEEVEVILL 72
|
|
| cinA |
cd00885 |
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon ... |
178-247 |
1.75e-04 |
|
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, where the domain is presumed to bind molybdopterin.
Pssm-ID: 238450 [Multi-domain] Cd Length: 170 Bit Score: 41.70 E-value: 1.75e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 336304352 178 IITSGDELvpveqtpLPHQIRSSNVHCIASLLKEYRLHVDFVH-IPDELSATQRAIEQALTQYEVLILCGG 247
Cdd:cd00885 4 IIAIGDEL-------LSGQIVDTNAAFLAKELAELGIEVYRVTvVGDDEDRIAEALRRASERADLVITTGG 67
|
|
| |
