|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
1-395 |
0e+00 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 663.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 1 MNPGLRRSTLALLASSLLLTIGRGATLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAI 80
Cdd:PRK10054 1 MNLSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 81 IAFACGFIAIPMVHNVVLVVLLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQSI 160
Cdd:PRK10054 81 TAFASGFIAIPLVNNVTLVVLFFALINCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 161 NLPFWLAAICSAFPLVFIQVWVTRSVAASEGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVADSG 240
Cdd:PRK10054 161 NLPFWLAAICSAFPLVFIQIWVQRSEKAIATETGSVWSPSVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVVADSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 241 FAEKVVAVVLPVNAVIVVSLQYAVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWGLSAAVFTIGEIIYAPGEY 320
Cdd:PRK10054 241 FAEKVVAVVLPVNAAMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEY 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332988400 321 MLIDNIAPAGMKASYFSAQSLGWLGAAVNPLASGVILTTLPAWSLFVVLIIAIVFAWALMLKGMRITPTQQAITC 395
Cdd:PRK10054 321 MLIDHIAPPGMKASYFSAQSLGWLGAAINPLVSGVILTTLPPWSLFVILALAIVAAWLLMLKGMRARPWGQPALC 395
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-384 |
1.82e-62 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 205.15 E-value: 1.82e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 21 IGRGATLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVV 100
Cdd:cd17329 13 LGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 101 LLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQSINLPFWLAAICSAFPLVFIQV 180
Cdd:cd17329 93 IALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 181 WVTRSVA--ASEGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVAdsGFAEKVVAVVLPVNAVIVV 258
Cdd:cd17329 173 LLPETRPkrRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEIL--GLGESLLGLLLALNALLIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 259 SLQYAVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSGdNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFSA 338
Cdd:cd17329 251 LLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFAN-TLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 332988400 339 QSLGW-LGAAVNPLASGVILTTLPAWSLFVVLIIAIVFAWALMLKGM 384
Cdd:cd17329 330 YALAWgLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-348 |
6.75e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.95 E-value: 6.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 21 IGRGATLPFMTIYLnRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVV 100
Cdd:COG2814 24 LGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 101 LLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPLVFIQ 179
Cdd:COG2814 103 AARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 180 VWVTRSVAASEGKNAAiwSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVAdsGFAEKVVAVVLPVNAVIVVS 259
Cdd:COG2814 183 RLLPESRPAARARLRG--SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL--GLSASAAGLLLALFGLGGVL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 260 LQYAVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSGdNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFSA- 338
Cdd:COG2814 259 GALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLy 337
|
330
....*....|
gi 332988400 339 QSLGWLGAAV 348
Cdd:COG2814 338 NSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-381 |
3.17e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.32 E-value: 3.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 21 IGRGATLPFMTIYLnRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVV 100
Cdd:cd17325 10 LGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 101 LLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPLVFIQ 179
Cdd:cd17325 89 LARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAALALLALVLAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 180 VWVTRSVAASEGKNAAIWSPS----VLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVAdsGFAEKVVAVVLPVNAV 255
Cdd:cd17325 169 LLLPEPRPPPNKRAVSAARLRsglrLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG--GLSPAQIGLLFGAQGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 256 IVVSLQYAVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSgDNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASY 335
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA-TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 332988400 336 FSAQSLGW-LGAAVNPLASGVILTTL-PAWSLFVVLIIAIVFAWALML 381
Cdd:cd17325 326 MGLFNTAFsLGMVLGPLLGGFLYDAFgFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-343 |
1.28e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 74.38 E-value: 1.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 21 IGRGATLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVV 100
Cdd:pfam07690 10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 101 LLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPLVFIQ 179
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 180 VWVTRSVAASEGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVADS-GFAEKVVAVVLPVNAVIVV 258
Cdd:pfam07690 170 LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVlGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 259 SLQYAVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSG--DNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYF 336
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329
|
....*..
gi 332988400 337 SAQSLGW 343
Cdd:pfam07690 330 GLYNTAG 336
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
29-358 |
1.15e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.16 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 29 FMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKR-----YMLLAIIAFACGFIAIPMVHNVVLVVLL- 102
Cdd:COG2211 32 YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLi 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 103 -----FALINCAYSVFSTVLKAWFADnLTATTK--TRIFSLNYTVLNIGWTVGPPLGTLLV-------MQSINLPFWLAA 168
Cdd:COG2211 112 yalvtYLLLGLAYTLVNIPYSALGAE-LTPDYEerTRLSSWRFAFAGLGGLLASVLPPPLVaafggdaALGYRLTALIFA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 169 ICSAFPLVFIQVWVTRSVAASEGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVAdsGFAEKVVAV 248
Cdd:COG2211 191 VLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAALVGL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 249 VLPVNAVIVVSLQYAVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSG-DNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIA 327
Cdd:COG2211 269 LLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
330 340 350
....*....|....*....|....*....|....*....
gi 332988400 328 PAG-------MKASYFSAQSLGW-LGAAVNPLASGVILT 358
Cdd:COG2211 349 DYDewktgrrREGLYFGIFTFAIkLGQALAGALAGLLLA 387
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
36-379 |
2.08e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 67.98 E-value: 2.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 36 RQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYSVFST 115
Cdd:cd17474 27 EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 116 VLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQSINLPFWLAAICSAFPLVFIQVWVTRSVA-ASEGKNA 194
Cdd:cd17474 107 LALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEkAKSSSAT 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 195 AIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVADSGFAEKVVAVVLPVNAVIVVSlqYAVGRRLTA-VNI 273
Cdd:cd17474 187 KLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGS--LFVGRLLKKrFGA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 274 RPMMTTGTVFFIAGLIGFIFSGDNLFFWGLsAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFSA-QSLGWLGAAVNPLA 352
Cdd:cd17474 265 RRILVIGLLLYALSLLLLGFVPSLALLLIA-IVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLyNFVRFLGQAVGPLL 343
|
330 340 350
....*....|....*....|....*....|.
gi 332988400 353 SGVILTTL----PAWSLFVVLIIAIVFAWAL 379
Cdd:cd17474 344 FGLLLEIFglsaPFLVGAAIALAAAVLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-381 |
5.00e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.68 E-value: 5.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 32 IYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYS 111
Cdd:cd06174 20 PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 112 VFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQSIN---LPFWLAAICSAFPLVFIQVWVTRSVAA 188
Cdd:cd06174 100 LIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALALLAAILLLLVVPDPPES 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 189 SEGKNAAIWSPSV------LLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVAdsGFAEKVVAVVLPVNAVIVVSLQY 262
Cdd:cd06174 180 ARAKNEEASSKSVlkllkrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG--GLSVAVAGLLLSLFGLAGALGSL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 263 AVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFSAQSL- 341
Cdd:cd06174 258 LLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTf 337
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 332988400 342 GWLGAAVNPLASGVILTTLPAWSLFVVLIIAIVFAWALML 381
Cdd:cd06174 338 GFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-381 |
1.81e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.92 E-value: 1.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 27 LPFMTIYLnRQYGLGVDLIGyALTSALTIGVIFSLGF-GILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFAL 105
Cdd:cd17489 16 LPVLPLYA-HDLGGSEAVAG-LVVGLFTLAALLARPFaGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 106 INCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPLVFIQVWVTR 184
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHlGFAVLFIVAAVLALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 185 SVAASEGKNAAIWSPSVLLRDKALLwFTLSAFLASFVGGAFASCISQYVMVVADSgfaekVVAVVLPVNAVIVVSLQYAV 264
Cdd:cd17489 174 PPVAAEEAEAGTRAFRRLVEKKVLP-PALILFLASIAYGAISTFLPLYAAERGIS-----NAGLFFTVYAIALLLSRPFS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 265 GRRLTAVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFwGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFSAQSLGW- 343
Cdd:cd17489 248 GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWML-LLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFd 326
|
330 340 350
....*....|....*....|....*....|....*...
gi 332988400 344 LGAAVNPLASGVILTTLPAWSLFVVLIIAIVFAWALML 381
Cdd:cd17489 327 LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-381 |
4.04e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 63.72 E-value: 4.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 26 TLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADK-FDKKRYMLLAIIAFACGFIAIPMVHN----VVLVV 100
Cdd:cd17471 15 VLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNywvlLLVGV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 101 LLFALINCAYS-VFSTVLKawFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPLVfI 178
Cdd:cd17471 95 VLLSLGAAAFPqLFALARE--YADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVlGFTGLFLLAALLYLVVAL-L 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 179 QVWVTRSVAASEGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYvmVVADSGFAEKVVAVVLPVNAVIVV 258
Cdd:cd17471 172 VLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLY--VTNELGGSESWVGLLFGLAAALEI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 259 SLQYAVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWGLSA--AVFtIGeIIYAPGEYMLIDNIAPAGMKAS-- 334
Cdd:cd17471 250 PIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLlnAIF-IG-ITAGLGISYFQDLMPGQPGLATtl 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 332988400 335 YFSAQSLGWLGAAvnpLASGVILTTLPAWSLFVVLIIAIVFAWALML 381
Cdd:cd17471 328 YSNASRIGSLLGG---LLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-377 |
1.11e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 62.60 E-value: 1.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 21 IGRGATLPFMTIYLNRQYGLGVD--LIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNvVL 98
Cdd:cd17330 10 LGFGIVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRN-LW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 99 VVLLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLV-MQSINLPFWLAAICSAFPLVF 177
Cdd:cd17330 89 LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStPYGYALPFLVAAALALLNLVL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 178 IQVWVTRsvaasegknaaiwspsvllrdkaLLWFTLSAFLASFVGGAFASCISQYVMvvADSGFAEKVVAVVLPVNAVIV 257
Cdd:cd17330 169 VLFFLPP-----------------------LRRLLLVYFLIALAFAGLESVFSLFLK--DRFGFSPSQIGLLLALVGIAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 258 VSLQYAVGRRLT-AVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWgLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYF 336
Cdd:cd17330 224 ILAQLLLIPRLAkRLGERKLLRLGLLLAIIGLLLLPFASSVPLLV-LAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 332988400 337 S-AQSLGWLGAAVNPLASGVILTTL----PAWSLFVVLIIAIVFAW 377
Cdd:cd17330 303 GiIQSLQSLARIIGPLLAGPLYSFLgpgvPFLLAAGLLLIALFLLS 348
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
27-382 |
1.59e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 62.23 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 27 LPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALI 106
Cdd:cd17472 16 LPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 107 -NCAYsvfSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLV-MQSINLPFWLAAICSAFPLVFIQVWVTR 184
Cdd:cd17472 96 gSGAI---SSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAaHLGVSGLFLITAILSLVSLLILLFFVPD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 185 SVAASEGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMvvaDSGFAEK-VVAVVLPVNAVIVVSLQYA 263
Cdd:cd17472 173 PPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLT---QLGGGKGqLWKVYLPAILIGFILMVPF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 264 VGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFS-AQSLG 342
Cdd:cd17472 250 VIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGiYNTSQ 329
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 332988400 343 WLGAAVNPLASGVILTTLPA--WSLFVVLIIAIVFAWALMLK 382
Cdd:cd17472 330 FLGSFLGGALGGLLWGLLGYssVFLTILILALLWLLVSFLLP 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-178 |
3.26e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.05 E-value: 3.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 5 LRRSTLALLASSLLLTIGRGATLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFA 84
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 85 CGFIAIPMVHNVVLVVLLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLP 163
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATP 356
|
170
....*....|....*
gi 332988400 164 FWLAAICSAFPLVFI 178
Cdd:cd17325 357 FLAAAALLLLAAVLF 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-390 |
4.80e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.56 E-value: 4.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 33 YLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYSV 112
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 113 FSTVLKAWFADnLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQSINLP-----FWLAAICSAFPLVFIQVWVTRSVA 187
Cdd:COG0738 113 LDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSwhlpyLILAVLLLLLALLFLRSKLPEIEE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 188 ASEGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVAdsGFAEKVVAVVLPVNAVIVVSLQYAVGRR 267
Cdd:COG0738 192 EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL--GLSEATAALGLSLFWGGMTIGRFLGGFL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 268 LTAVNIRPMMTTGTVFFIAGLIGFIFSGDN------LFFWGLSAAVF---TIGEIIYAPGEYmlidniapAGMKASYFSA 338
Cdd:COG0738 270 LKRFGPVRLLRLSALLAAVGLLLALLAPGPwlaligLALVGLGLSLMfptIFSLALDGLGKR--------TAAAVSAVLI 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 332988400 339 qsLGWLGAAVNPLASGVILTTLPAWSLFVVLIIAIVFAWALMLKGMRITPTQ 390
Cdd:COG0738 342 --MGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-380 |
3.88e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.41 E-value: 3.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 21 IGRGATLPFMTIYLNRQyGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVV 100
Cdd:cd17477 10 LGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 101 LLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTlLVMQSINLPFWLAAICSAF---PLVF 177
Cdd:cd17477 89 LLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAAVLLLLalvPLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 178 IQVWVTRSVAASEGKNAAIWSPSVLLrdkallwfTLSAFLASFVGGAFASCISQYVMvvaDSGFAEKVVAVVLPVNAVIV 257
Cdd:cd17477 168 TRRAAPEIEEAESISLRRLLRIAPLA--------LLGAFVAGFLEGAFYSLLPLYGL---RLGLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 258 VSLQYAVGRRLTAVNIRPMMT-TGTVFFIAGLIGFIFSGDNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYF 336
Cdd:cd17477 237 LLLQWPLGWLADRFDRRRVLLgCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 332988400 337 SAQSLGWLGAAVNPLASGVILTTLPAWSLFVVLIIAIVFAWALM 380
Cdd:cd17477 317 ALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
36-380 |
5.61e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 5.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 36 RQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYSV--- 112
Cdd:COG2807 46 ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVgnv 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 113 -FSTVLKAWFADNLTATTktrifSLNYTVLNIGWTVGPPLgTLLVMQSINLPFWLAaICSAFPLVFIQVW--VTRSVAAS 189
Cdd:COG2807 126 lLPGLIKRWFPDRVGLMT-----GLYTAAMGLGAALAAGL-TVPLAAALGWRGALA-VWALLALLALLLWlpLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 190 EGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMvvaDSGFAEKVVAVVLPVNAVIVVSLQYAVGRRLT 269
Cdd:COG2807 199 AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR---DAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 270 AV-NIRPMMTTGTVFFIAGLIGFIFSGDNLFFwgLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFS--AQSLGWLGA 346
Cdd:COG2807 276 RLgDRRPLLLLLGLLGLAGLLGLLLAPGSLPW--LWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSgmAQSVGYLLA 353
|
330 340 350
....*....|....*....|....*....|....
gi 332988400 347 AVNPLASGVILTTLPAWSLFVVLIIAIVFAWALM 380
Cdd:COG2807 354 ALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
44-372 |
9.39e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 9.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 44 LIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLF-----ALINCAYSVFSTVLK 118
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLllvlaFLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 119 AWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAIC---SAFPLVFIQVWVTRSVAASEG--K 192
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALlGPGGAFAINALSfllSALLLLFIRRPPPAAPGESSSllL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 193 NAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVadSGFAEKVVAVVLPVNAVIVVSLQYAVGRRLTAVN 272
Cdd:cd06173 195 RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV--LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 273 IRPMMTTGTVFFIAGLIGFIFSGdNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFSAQSLgwLGAAVNPLA 352
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSP-SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNA--LNSGAMPLG 349
|
330 340
....*....|....*....|
gi 332988400 353 SGVILTTLPAWSLFVVLIIA 372
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLA 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-147 |
3.06e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 3.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 6 RRSTLALLASSLLLTIGRGATLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFAC 85
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332988400 86 GFIAIPMVHNVVLVVLLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTV 147
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-381 |
5.57e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.93 E-value: 5.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 36 RQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYSVFST 115
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 116 VLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPLVFIQVWVTRSVAASEGKNA 194
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 195 AIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISqyVMVVADSGFAEKVVAVVLPVNAVIVVSLQYAVGrRLTAVNIR 274
Cdd:cd17324 187 LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLA--PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG-RLADRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 275 PMMTTGTVFFIAGLIGFIFSGDNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGmKASYFSAQSLGW-LGAAVNPLAS 353
Cdd:cd17324 264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYnLGGALGAALG 342
|
330 340
....*....|....*....|....*...
gi 332988400 354 GVILTTLPAWSLFVVLIIAIVFAWALML 381
Cdd:cd17324 343 GLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-381 |
2.26e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 26 TLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFAL 105
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 106 INCA----YSVFSTVLKAWFADNLTATtktrIFSLNYTVLNIGWTVGPPLGTLLV-MQSINLPFWLAAICSAFPLVFIQV 180
Cdd:COG2223 103 LGIGgggsFAVGIALVSKWFPPDRRGL----ALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 181 WVTRSVA-ASEGKNAAIWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMVVAdsGFAEKVVAVVLPVNAVIVVS 259
Cdd:COG2223 179 FLRDPPAgAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF--GLSAATAGLLAALFALLGAL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 260 LQYAVGRRLTAVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFSAQ 339
Cdd:COG2223 257 GRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLV 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 332988400 340 SLGW-LGAAVNPLASGVILTTLPAWSL-FVVLIIAIVFAWALML 381
Cdd:COG2223 337 GAAGgLGGFLGPLLFGALLDATGSYTAaFLVFAVLALVALVLTL 380
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-311 |
2.85e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.62 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 33 YLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYSV 112
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 113 FStVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQSINLPFWLAAICsAFPLVFIQVWVTRSVAASEGK 192
Cdd:cd17478 101 FH-PEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLII-PGLAVALLLLRLRPLKKPEAK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 193 NAA---IWSPSVLLRDKALLWFTLSAFLASFVGGAFASCISQYVMvvaDSGFAEKVVAVVLPVNAVIVVSLQYAVGRRLT 269
Cdd:cd17478 179 KAAaksSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV---QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSD 255
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 332988400 270 AVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWGLSAAVFTIG 311
Cdd:cd17478 256 RFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLF 297
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-381 |
7.10e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.48 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 25 ATLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFA 104
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 105 LINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFpLVFIQVWvt 183
Cdd:COG2271 107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAfGWRAAFLILGLPGLL-LALLRFW-- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 184 rsvaasegknaaiwspsvllrdkallWFTLSAFLASFVGGAFASCISQYVMVVADSGFAEKVVAVVLPVNAVIVVSLqyA 263
Cdd:COG2271 184 --------------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSL--L 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 264 VGR---RLTAVNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWGLSAAVFTIGeiIYAPGEYMLIDNIAPAGMKASYFS-AQ 339
Cdd:COG2271 236 GGWlsdRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG--GAFGLLWALAAELFPKKARGTASGlVN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 332988400 340 SLGWLGAAVNPLASGVILTTLPAWSLFVVLIIAIVFAWALML 381
Cdd:COG2271 314 TFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
32-178 |
1.42e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 32 IYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYS 111
Cdd:cd17370 223 ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMG 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332988400 112 VFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPL-GTLLVMQSINLPFWLAAICSAFPLVFI 178
Cdd:cd17370 303 AQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIaGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-183 |
1.44e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 41.48 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 57 VIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYSVFSTVLKAWFADNLTATTKTRIFSL 136
Cdd:TIGR00880 12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGL 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 332988400 137 NYTVLNIGWTVGPPLGTLLVMQSI-NLPFWLAAICSAFPLVFIQVWVT 183
Cdd:TIGR00880 92 MSAGIALGPLLGPPLGGVLAQFLGwRAPFLFLAILALAAFILLAFLLP 139
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-178 |
1.93e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 21 IGRGATLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMV--HNVVL 98
Cdd:COG2211 242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWL 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 99 VVLLFALINCAYSVFSTVLKAWFADNL---TATTKTR----IFSLNYTVLNIGWTVGPPLGTLL---------VMQSINL 162
Cdd:COG2211 322 LLVLAALAGIGLGAILVLPWAMLADVVdydEWKTGRRreglYFGIFTFAIKLGQALAGALAGLLlalfgyvagAAQSPSA 401
|
170
....*....|....*.
gi 332988400 163 PFWLAAICSAFPLVFI 178
Cdd:COG2211 402 LTGIRLLFFLLPAVLL 417
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-184 |
3.55e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.16 E-value: 3.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 29 FMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAI--IAFACGFIAIPMVHNVVLVVLLFALI 106
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIglLLAALALLLLALLPSPALAIALLFLA 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 332988400 107 NCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPL-GTLLVMQSINLPFWLAAICSAFPLVFIQVWVTR 184
Cdd:COG2271 282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLvGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-381 |
1.08e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 44 LIGYALT-SALTIgVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLFALINCAYSVFSTVLKAWFA 122
Cdd:cd17473 36 LVPLLLTlPALFI-ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 123 DNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQSINLPFWLAAIcsAFP-LVFIQVWVTRSVAASEGKNAAIWSPSV 201
Cdd:cd17473 115 DYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLL--ALPvLILVLLFLPEPARKSKSAASPGAATAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 202 LLRDKALLWFTLSAFLASFVggaFASCISQYVMVVADSG-FAEKVVAVVLPVNAVIVVSLQYAVGRRLTAVNIRPMMTTG 280
Cdd:cd17473 193 ALPWKRVLPIYFLAFLAMLL---FYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 281 TVFFIAGLIGFIFSGDNLFFwGLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKASYFSA-QSLGWLGAAVNPLASGVIL-- 357
Cdd:cd17473 270 FALMALGFLLLALASGLWVV-LLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIvTSAFFLGQFLSPLVLGPLVnl 348
|
330 340
....*....|....*....|....*.
gi 332988400 358 --TTLPAWSLFVVLIIAIVFAWALML 381
Cdd:cd17473 349 tgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
39-381 |
1.32e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 39 GLGVDLIGYALTSALTIGVIFSLGFGILADKFdkKRYMLLAIIAFACGFIAIPM---VHNVVLVVLLFALINCAYSVFST 115
Cdd:cd17370 30 GASAAAVGLIEGLAEALGSLLRLFSGYLSDRT--GKRKPLVILGYGLSALAKPLlalAGSWQLVLLLRILERLGKGIRTP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 116 VLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQSIN---LPFWLAAICSAFPLVFIQVWVTRSVAASEGK 192
Cdd:cd17370 108 PRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyrTIFLLAAIPALLALLILLFVVKEYPRPPKLR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 193 NAAIWSPSVLLrDKALLWFTLSAFL--ASFVGGAFascisqYVMVVADSGFAEKVVAVVLPVNAVIVVSLQYAVGRRLTA 270
Cdd:cd17370 188 KKSKKTSLKKL-PKAFWLYLLAVALfaLGNFSFAF------LILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 271 VNIRPMMTTGTVFFIAGLIGFIFSGDNLFFWgLSAAVFTIGEIIYAPGEYMLIDNIAPAGMKAS----YFSAQSLGWLGA 346
Cdd:cd17370 261 IGRKKLLILGYLSLALAYLGFALGSSLWLLL-LGFILWGLYMGAQESIERAAVADLVPAELRGTayglFNTVVGIGWLLA 339
|
330 340 350
....*....|....*....|....*....|....*
gi 332988400 347 AvnpLASGVILTTLPAWSLFVVLIIAIVFAWALML 381
Cdd:cd17370 340 S---LIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-173 |
6.09e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 6.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332988400 24 GATLPFMTIYLNRQYGLGVDLIGYALTSALTIGVIFSLGFGILADKFDKKRYMLLAIIAFACGFIAIPMVHNVVLVVLLF 103
Cdd:cd06173 225 GALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAAL 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 332988400 104 ALINCAYSVFSTVLKAWFADNLTATTKTRIFSLNYTVLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAF 173
Cdd:cd06173 305 FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAlGLSAVFLLAGALLLL 375
|
|
| |
