|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
114-1723 |
0e+00 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 1271.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 114 PLAQSDDENAAIERPAPAQAGAAGAKGKQVDGAWAVGDNPRVVYFPYVRPQRSYAVQWQGDVPAGDGKSTLGAVGHCVVN 193
Cdd:COG2373 34 ALPLSPPPALALAIAALVLPAAPLLALLLAPLLLALAAAASALALAATLLALSLLSAAALLLLALLAALALAVRAAALAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 194 TQAMPPSFYFASRGVVLPAGQNGGLPVATVNLAEVDVQFLRVEPDRVPEFFGSVLGIGNDAGADDRDDADDWRYADNRSL 273
Cdd:COG2373 114 SSALAAAAAALALAAALLAAALLALLAALAAAAALALALALAAAAAAALAALLAAAAAALLALAALAAELAALLALALVL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 274 KGSVSNWDLDRLHGLTTsvyqgRFLTDDKPNRRHVTFLPIEGVKELQEPGIYVAVMSQPGRFRYE---YQVTYFYVSDIG 350
Cdd:COG2373 194 AAALLAPAALSEVALLL-----EPDLKGKLNKRVTTALPLSELLALLKPGVYLVVARFPGDYSYNgesRATQWFLVSDLG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 351 LHTRRYAERIEAYTVSLKDGVAIPGALVEVLDGAGKVLAKANSDAQGHVRIDG-----DFAKSKVLRASRGKEMTVLALG 425
Cdd:COG2373 269 LTAKRGDDGLLVFVTSLSTGKPVAGAEVELYDRNGQVLATATTDADGLARFPAgdrgeGGRAPALLVARKGGDFAFLDLD 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 426 E-PALDLSEFDVGG-HPGRSNNLFVYAGRNLYRPGETFHVSVLPRDPDGRPLAAAPVSATLKRPDGRVVRTALWHPakDQ 503
Cdd:COG2373 349 DgPALDLSDFDVGGrAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGLPLTLELTDPDGKEVRRQTLTL--NE 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 504 PGYIEQAIELPVDAQTGAWMLELRIDPAArlPDAAWKFQVEEFLPERMKLQLDSAQTVLQPGQPWRVDVQGDYLYGAPAA 583
Cdd:COG2373 427 FGGYSFSFPLPEDAPTGTWRLELYVDPKP--ALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAA 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 584 GNRLLSSFQVKRNRYALPQqWPGFIFGDVADDTRRHYEELPESELDDTGAGQLEID-PHTDGTHSPMSVRVSASLLELGG 662
Cdd:COG2373 505 GLKVEGEVTLRPARTAFPG-YPGYRFGDPDEEFEPEELDLGEGTLDADGKASLSLPlPDAPDAPGPLRATVEASVFESGG 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 663 RPVVRSLERTVWPAPQLIAVR-PLFDRDvaREGAPAAFEITRVDASGKVVPVQQAQVRLYHEERQYYWRFDDQRGWHSGY 741
Cdd:COG2373 584 RPVTRSATVPVHPADFYVGIRlPLFDGD--PEGAPATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGGWRYES 661
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 742 TENEELTDSRVVDVGERTPLTLN---VGWGRYRLEIADPQTGETLRYRFYAGWNAQDADavgNRPDRVQLKLEGVPARPG 818
Cdd:COG2373 662 QEKEEPVAEGTLTTGADGPASLSltpVEWGRYRLEVKDPDGGLATSVRFYAGGNASWGA---ERPDRLELSLDKESYKPG 738
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 819 DTVAMTITPPHDGQALVTVEGDRMLWSKWVPVQASGTQVEIPVDKAWkRHDLYVSATVFRPGSQGDRVTPARALGLAFLP 898
Cdd:COG2373 739 ETAKLLIQSPFAGRALVTVERDGVLETQWVDVKGGGTTVEIPVTEDW-APNAYVSATLVRPGDSTANDMPARAYGVAPLP 817
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 899 IASDERRLQVSLSAPAKTRPETRATVRVKVEGAAGKAARVTLSAVDVGILNINQYATPDPLDFFFGKHRYAPELLDIYGK 978
Cdd:COG2373 818 VDPPARRLKVELTAPEKLRPGETLTVTVKVKGAAGKAAEVTLAAVDEGILNLTGYKTPDPLDFFYGKRALGVETRDLYGR 897
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 979 LIEKMDGTQGRLKWGGDAAMRGDSRSLP--KKVKLVDLFSGPVKLDDKGEADIALDLPDFNGTLRLMAVAFTADQFGSAD 1056
Cdd:COG2373 898 LIGAFGGAAGALRSGGDGALGRGGNPKPprKRFKPVALFSGPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDRFGSAE 977
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1057 REMTVAAPIVAELNTPRFITPGDQTAIALDVTNLSGATQKITVRLQALDPLAI-ADGTRTLTLKDKQRSTLRFVATTTGS 1135
Cdd:COG2373 978 ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLeGEATQTVTLAAGGRATVRFPLKAPDA 1057
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1136 yGLGLMRLSVDGEGAaepvRIVRESVLQVQPAHAPERRVRRVRLNPGEALPAPGDWTSAYFPDSVSVSMTLSNRPPINVS 1215
Cdd:COG2373 1058 -GDAKVTVTATGGGE----SDAREVELPVRPANPLVTRATSGVLAPGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLA 1132
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1216 RLVDGLLTYPYGCTEQTISAAIPWVLIDEaAAERFGLKVYSRADRESRVASALGRLAGMRAANGSYSLWGDSSSRDVWLT 1295
Cdd:COG2373 1133 GLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWPGGSESDPWLT 1211
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1296 AYTVGFMQDVRDHEFNLAPALLERPRQWLLEQLQqasggfgtwspnlrrtlasgrfdeNDAAILREDHRRFAGLAAAALV 1375
Cdd:COG2373 1212 AYATDFLLEAREAGYAVPDDALDRALDYLRNYLR------------------------NPWEIEYDDAYRLAVRAYALYV 1267
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1376 LARDGKAPLSTVRQLYDNyQERARSPLPLMQLAAAFKLMGDEGRMKTALDEAMTRSYGINRRagsnylDEWLGDYGSAVR 1455
Cdd:COG2373 1268 LARAGKADLGDLRYLYDR-RKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGAR------DYWYGDYGSPLR 1340
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1456 DYALSYALVNQYGLKHDRTEALLDQVGGYLGVRSYLSTQEQMALLLAAGA--TGAESRTPWQAALQIGTGELKTLQGRDD 1533
Cdd:COG2373 1341 DQALALALLAELGPDAPLAPKLARWLAKALKSGRWLSTQETAWALLALAAyaRAAGASPDFTATLTLDGKTLPLTGRGPL 1420
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1534 HTLALSAGDLA--GLQLRNTGSQSMFAEFDVQGT-TMAAPAPRSDVIRLKRVWYRPDGTAWNGGTLQTGDMLVVWVQAEA 1610
Cdd:COG2373 1421 ARVTLPAAELLagPLTITNTGDGPLYYTLTLSGYpAEGPPPAASNGLEIERRYYDLDGKPIDPASLKQGDLVVVRLTVTA 1500
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1611 SRL-IPDALVVDRVPAGFEIENLNLSQSPDMQDWTiggrrvaesMADPNIKHREFRDDRYVAA-TMLGRGKVDIFYLARV 1688
Cdd:COG2373 1501 PSGrVENVAVVDPLPAGFEIENPRLATSGDLGDWL---------GDSWQPDHQEFRDDRVVAAfDLDPAGTYTFAYLVRA 1571
|
1610 1620 1630
....*....|....*....|....*....|....*
gi 332383118 1689 VTPGRYSVPATEAEDMYRPELRAVGDSwSSIEIRD 1723
Cdd:COG2373 1572 VTPGTFVLPPAQAEDMYRPEVRARSAG-GRVTVVA 1605
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1214-1505 |
3.74e-45 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 165.25 E-value: 3.74e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1214 VSRLVDGLLTYPYGCTEQTISAAIPWVLIDEAAAERFGLKVYSRADRESRVASALGRLAGMRAANGSYSLWGDSSSRDVW 1293
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1294 LTAYTVGFMQDVRDHEFnLAPALLERPRQWLLEQlQQASGGFgtwsPNLRRTLASGRFDEND----------AAILREdh 1363
Cdd:cd02891 81 LTAYVVKFLSQARKYID-VDENVLARALGWLVPQ-QKEDGSF----RELGPVIHREMKGGVDdsvsltayvlIALAEA-- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1364 rrfaglaaaalvlardGKA-PLSTVRQLYD--NYQERARSPLPLMQLAAAFKLMGDEGRMKTALDEAMTRSYGINRRAGS 1440
Cdd:cd02891 153 ----------------GKAcDASIEKALAYleTQLDGLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHW 216
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 332383118 1441 NylDEWLGDYGSAVRDYALSYALVNQYGLKH----DRTEALLDQVGGYLGvrSYLSTQEQMALLLAAGA 1505
Cdd:cd02891 217 S--LSWPGDYGSSLRVEATAYALLALLKLGDleeaGPIAKWLAQQRNSGG--GFLSTQDTVVALQALAA 281
|
|
| bMG5 |
pfam17972 |
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
549-675 |
7.18e-45 |
|
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the N-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG5 domain.
Pssm-ID: 436183 Cd Length: 127 Bit Score: 158.45 E-value: 7.18e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 549 ERMKLQLDSAQTVLQPGQPWRVDVQGDYLYGAPAAGNRLLSSFQVKRNRYALPqQWPGFIFGDVADDTRRHYEELPESEL 628
Cdd:pfam17972 1 ERMDLDLSLPDAPLAPGDPAELDVDARYLYGAPAAGLRLEGELTLRPARHALA-GFPGYRFGRHDEELLKRTRDLPDLTT 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 332383118 629 DDTGAGQLEID-PHTDGTHSPMSVRVSASLLELGGRPVVRSLERTVWP 675
Cdd:pfam17972 80 DAQGKATLTVPlPEWPAATRPLEARVTVSLLESGGRPVERSLTRPVWP 127
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
114-1723 |
0e+00 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 1271.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 114 PLAQSDDENAAIERPAPAQAGAAGAKGKQVDGAWAVGDNPRVVYFPYVRPQRSYAVQWQGDVPAGDGKSTLGAVGHCVVN 193
Cdd:COG2373 34 ALPLSPPPALALAIAALVLPAAPLLALLLAPLLLALAAAASALALAATLLALSLLSAAALLLLALLAALALAVRAAALAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 194 TQAMPPSFYFASRGVVLPAGQNGGLPVATVNLAEVDVQFLRVEPDRVPEFFGSVLGIGNDAGADDRDDADDWRYADNRSL 273
Cdd:COG2373 114 SSALAAAAAALALAAALLAAALLALLAALAAAAALALALALAAAAAAALAALLAAAAAALLALAALAAELAALLALALVL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 274 KGSVSNWDLDRLHGLTTsvyqgRFLTDDKPNRRHVTFLPIEGVKELQEPGIYVAVMSQPGRFRYE---YQVTYFYVSDIG 350
Cdd:COG2373 194 AAALLAPAALSEVALLL-----EPDLKGKLNKRVTTALPLSELLALLKPGVYLVVARFPGDYSYNgesRATQWFLVSDLG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 351 LHTRRYAERIEAYTVSLKDGVAIPGALVEVLDGAGKVLAKANSDAQGHVRIDG-----DFAKSKVLRASRGKEMTVLALG 425
Cdd:COG2373 269 LTAKRGDDGLLVFVTSLSTGKPVAGAEVELYDRNGQVLATATTDADGLARFPAgdrgeGGRAPALLVARKGGDFAFLDLD 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 426 E-PALDLSEFDVGG-HPGRSNNLFVYAGRNLYRPGETFHVSVLPRDPDGRPLAAAPVSATLKRPDGRVVRTALWHPakDQ 503
Cdd:COG2373 349 DgPALDLSDFDVGGrAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGLPLTLELTDPDGKEVRRQTLTL--NE 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 504 PGYIEQAIELPVDAQTGAWMLELRIDPAArlPDAAWKFQVEEFLPERMKLQLDSAQTVLQPGQPWRVDVQGDYLYGAPAA 583
Cdd:COG2373 427 FGGYSFSFPLPEDAPTGTWRLELYVDPKP--ALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAA 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 584 GNRLLSSFQVKRNRYALPQqWPGFIFGDVADDTRRHYEELPESELDDTGAGQLEID-PHTDGTHSPMSVRVSASLLELGG 662
Cdd:COG2373 505 GLKVEGEVTLRPARTAFPG-YPGYRFGDPDEEFEPEELDLGEGTLDADGKASLSLPlPDAPDAPGPLRATVEASVFESGG 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 663 RPVVRSLERTVWPAPQLIAVR-PLFDRDvaREGAPAAFEITRVDASGKVVPVQQAQVRLYHEERQYYWRFDDQRGWHSGY 741
Cdd:COG2373 584 RPVTRSATVPVHPADFYVGIRlPLFDGD--PEGAPATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGGWRYES 661
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 742 TENEELTDSRVVDVGERTPLTLN---VGWGRYRLEIADPQTGETLRYRFYAGWNAQDADavgNRPDRVQLKLEGVPARPG 818
Cdd:COG2373 662 QEKEEPVAEGTLTTGADGPASLSltpVEWGRYRLEVKDPDGGLATSVRFYAGGNASWGA---ERPDRLELSLDKESYKPG 738
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 819 DTVAMTITPPHDGQALVTVEGDRMLWSKWVPVQASGTQVEIPVDKAWkRHDLYVSATVFRPGSQGDRVTPARALGLAFLP 898
Cdd:COG2373 739 ETAKLLIQSPFAGRALVTVERDGVLETQWVDVKGGGTTVEIPVTEDW-APNAYVSATLVRPGDSTANDMPARAYGVAPLP 817
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 899 IASDERRLQVSLSAPAKTRPETRATVRVKVEGAAGKAARVTLSAVDVGILNINQYATPDPLDFFFGKHRYAPELLDIYGK 978
Cdd:COG2373 818 VDPPARRLKVELTAPEKLRPGETLTVTVKVKGAAGKAAEVTLAAVDEGILNLTGYKTPDPLDFFYGKRALGVETRDLYGR 897
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 979 LIEKMDGTQGRLKWGGDAAMRGDSRSLP--KKVKLVDLFSGPVKLDDKGEADIALDLPDFNGTLRLMAVAFTADQFGSAD 1056
Cdd:COG2373 898 LIGAFGGAAGALRSGGDGALGRGGNPKPprKRFKPVALFSGPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDRFGSAE 977
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1057 REMTVAAPIVAELNTPRFITPGDQTAIALDVTNLSGATQKITVRLQALDPLAI-ADGTRTLTLKDKQRSTLRFVATTTGS 1135
Cdd:COG2373 978 ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLeGEATQTVTLAAGGRATVRFPLKAPDA 1057
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1136 yGLGLMRLSVDGEGAaepvRIVRESVLQVQPAHAPERRVRRVRLNPGEALPAPGDWTSAYFPDSVSVSMTLSNRPPINVS 1215
Cdd:COG2373 1058 -GDAKVTVTATGGGE----SDAREVELPVRPANPLVTRATSGVLAPGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLA 1132
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1216 RLVDGLLTYPYGCTEQTISAAIPWVLIDEaAAERFGLKVYSRADRESRVASALGRLAGMRAANGSYSLWGDSSSRDVWLT 1295
Cdd:COG2373 1133 GLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWPGGSESDPWLT 1211
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1296 AYTVGFMQDVRDHEFNLAPALLERPRQWLLEQLQqasggfgtwspnlrrtlasgrfdeNDAAILREDHRRFAGLAAAALV 1375
Cdd:COG2373 1212 AYATDFLLEAREAGYAVPDDALDRALDYLRNYLR------------------------NPWEIEYDDAYRLAVRAYALYV 1267
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1376 LARDGKAPLSTVRQLYDNyQERARSPLPLMQLAAAFKLMGDEGRMKTALDEAMTRSYGINRRagsnylDEWLGDYGSAVR 1455
Cdd:COG2373 1268 LARAGKADLGDLRYLYDR-RKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGAR------DYWYGDYGSPLR 1340
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1456 DYALSYALVNQYGLKHDRTEALLDQVGGYLGVRSYLSTQEQMALLLAAGA--TGAESRTPWQAALQIGTGELKTLQGRDD 1533
Cdd:COG2373 1341 DQALALALLAELGPDAPLAPKLARWLAKALKSGRWLSTQETAWALLALAAyaRAAGASPDFTATLTLDGKTLPLTGRGPL 1420
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1534 HTLALSAGDLA--GLQLRNTGSQSMFAEFDVQGT-TMAAPAPRSDVIRLKRVWYRPDGTAWNGGTLQTGDMLVVWVQAEA 1610
Cdd:COG2373 1421 ARVTLPAAELLagPLTITNTGDGPLYYTLTLSGYpAEGPPPAASNGLEIERRYYDLDGKPIDPASLKQGDLVVVRLTVTA 1500
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1611 SRL-IPDALVVDRVPAGFEIENLNLSQSPDMQDWTiggrrvaesMADPNIKHREFRDDRYVAA-TMLGRGKVDIFYLARV 1688
Cdd:COG2373 1501 PSGrVENVAVVDPLPAGFEIENPRLATSGDLGDWL---------GDSWQPDHQEFRDDRVVAAfDLDPAGTYTFAYLVRA 1571
|
1610 1620 1630
....*....|....*....|....*....|....*
gi 332383118 1689 VTPGRYSVPATEAEDMYRPELRAVGDSwSSIEIRD 1723
Cdd:COG2373 1572 VTPGTFVLPPAQAEDMYRPEVRARSAG-GRVTVVA 1605
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1214-1505 |
3.74e-45 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 165.25 E-value: 3.74e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1214 VSRLVDGLLTYPYGCTEQTISAAIPWVLIDEAAAERFGLKVYSRADRESRVASALGRLAGMRAANGSYSLWGDSSSRDVW 1293
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1294 LTAYTVGFMQDVRDHEFnLAPALLERPRQWLLEQlQQASGGFgtwsPNLRRTLASGRFDEND----------AAILREdh 1363
Cdd:cd02891 81 LTAYVVKFLSQARKYID-VDENVLARALGWLVPQ-QKEDGSF----RELGPVIHREMKGGVDdsvsltayvlIALAEA-- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1364 rrfaglaaaalvlardGKA-PLSTVRQLYD--NYQERARSPLPLMQLAAAFKLMGDEGRMKTALDEAMTRSYGINRRAGS 1440
Cdd:cd02891 153 ----------------GKAcDASIEKALAYleTQLDGLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHW 216
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 332383118 1441 NylDEWLGDYGSAVRDYALSYALVNQYGLKH----DRTEALLDQVGGYLGvrSYLSTQEQMALLLAAGA 1505
Cdd:cd02891 217 S--LSWPGDYGSSLRVEATAYALLALLKLGDleeaGPIAKWLAQQRNSGG--GFLSTQDTVVALQALAA 281
|
|
| bMG5 |
pfam17972 |
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
549-675 |
7.18e-45 |
|
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the N-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG5 domain.
Pssm-ID: 436183 Cd Length: 127 Bit Score: 158.45 E-value: 7.18e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 549 ERMKLQLDSAQTVLQPGQPWRVDVQGDYLYGAPAAGNRLLSSFQVKRNRYALPqQWPGFIFGDVADDTRRHYEELPESEL 628
Cdd:pfam17972 1 ERMDLDLSLPDAPLAPGDPAELDVDARYLYGAPAAGLRLEGELTLRPARHALA-GFPGYRFGRHDEELLKRTRDLPDLTT 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 332383118 629 DDTGAGQLEID-PHTDGTHSPMSVRVSASLLELGGRPVVRSLERTVWP 675
Cdd:pfam17972 80 DAQGKATLTVPlPEWPAATRPLEARVTVSLLESGGRPVERSLTRPVWP 127
|
|
| bMG6 |
pfam17962 |
Bacterial macroglobulin domain 6; This macroglobulin domain is found in bacterial alpha 2 ... |
682-791 |
1.75e-35 |
|
Bacterial macroglobulin domain 6; This macroglobulin domain is found in bacterial alpha 2 macroglobulin proteins. It adopts an Ig-like beta sandwich fold.
Pssm-ID: 436175 Cd Length: 112 Bit Score: 131.22 E-value: 1.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 682 VRPLFDRDVAREGAPAAFEITRVDASGKVVPVQQAQVRLYHEERQYYWRFDDqRGWHSGYTENEELTDSRVVDVGERTPL 761
Cdd:pfam17962 2 IRPLFDDGSLEEGKEAAFEVVAVDADGKPVAVQGLEWTLYREEWDYQWYRQD-GGWSYEPVTRDKRVATGTVDTGADGPA 80
|
90 100 110
....*....|....*....|....*....|..
gi 332383118 762 TLN--VGWGRYRLEIADPQTGETLRYRFYAGW 791
Cdd:pfam17962 81 TISlpVDWGRYRLEVEDPGGGAATSVRFYAGW 112
|
|
| bMG3 |
pfam11974 |
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial ... |
346-441 |
3.93e-28 |
|
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial alpha2-macroglobulins.
Pssm-ID: 432232 [Multi-domain] Cd Length: 102 Bit Score: 109.61 E-value: 3.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 346 VSDIGLHTRRYAERIEAYTVSLKDGVAIPGALVEVLDGAGKVLAKANSDAQGHVRIDG-----DFAKSKVLRASRGKEMT 420
Cdd:pfam11974 1 VSDLGLHAKQGRDGLLVWVTSLDSGKPVAGVEVRLLDCNGQVLATGTTDAQGHARFEGpltrdGGAAPALVSARKDGDFA 80
|
90 100
....*....|....*....|..
gi 332383118 421 VLAL-GEPALDLSEFDVGGHPG 441
Cdd:pfam11974 81 FLRLdWGPALDLSDFDVGGRPP 102
|
|
| bMG10 |
pfam17973 |
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
1577-1708 |
7.16e-27 |
|
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9.
Pssm-ID: 465598 Cd Length: 128 Bit Score: 107.00 E-value: 7.16e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1577 IRLKRVWYRPDGTAWN---GGTLQTGDMLVVWVQAEASRLIPDALVVDRVPAGFEIENLNLSQSPDMQDwtiggrrvaES 1653
Cdd:pfam17973 2 LSVTRRFYVLEGSGVSasdAETLKVGDKVRVRLTVTTDRDRDFVALEDPLPAGLEPVNPLSGYTWEGGL---------GY 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 332383118 1654 MADPNIKHREFRDDRYVA-ATMLGRGKVDIFYLARVVTPGRYSVPATEAEDMYRPE 1708
Cdd:pfam17973 73 PDNTQPSYREVRDDRVRFfADYLPKGTYTFEYLVRAVTPGTFTVPPATAESMYAPE 128
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
446-543 |
3.23e-21 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 89.68 E-value: 3.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 446 LFVYAGRNLYRPGETFHVSVLPRDPDGRPLAAAPVSATLKRPDGRVVRTALWhpAKDQPGYIEQAIELPVDAQTGAWMLE 525
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPL--TTDEFGGFSGSFPLPETAPTGTYTVV 79
|
90
....*....|....*...
gi 332383118 526 LRIDPAARLpdAAWKFQV 543
Cdd:pfam01835 80 LRDGAGGSL--GSGSFRV 95
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
1214-1505 |
2.28e-19 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 90.69 E-value: 2.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1214 VSRLVDGLLTYPYG--------CTEQTISAAIPWVLIDEAaaerfGLKVYSRADRESRVASALGRLAGMRAANGSYSLWG 1285
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLL-----LAATGIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1286 DSSSRDVWLTAYTVGFMQDVRDHEFnLAPALLERPRQWLLeQLQQASGGFGTWSPNLRRTLAsgrfDEND-------AAI 1358
Cdd:cd00688 76 GNDYPSLWLTAYALKALLLAGDYIA-VDRIDLARALNWLL-SLQNEDGGFREDGPGNHRIGG----DESDvrltayaLIA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1359 LREdhrrfaglaaaalVLARDGKAPLSTVRQLYDNYQERARS--------PLPLMQLAAAFKLMG--DEGRMKTALDEAM 1428
Cdd:cd00688 150 LAL-------------LGKLDPDPLIEKALDYLLSCQNYDGGfgpggeshGYGTACAAAALALLGdlDSPDAKKALRWLL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1429 TRSygiNRRAGSNYLDEWLGDYGSAVRDYALSYALVNQ-YGLKHDRTEALLD-------QVGGYLGVRSYL-STQEQMAL 1499
Cdd:cd00688 217 SRQ---RPDGGWGEGRDRTNKLSDSCYTEWAAYALLALgKLGDLEDAEKLVKwllsqqnEDGGFSSKPGKSyDTQHTVFA 293
|
....*.
gi 332383118 1500 LLAAGA 1505
Cdd:cd00688 294 LLALSL 299
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
806-950 |
3.25e-17 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 80.09 E-value: 3.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 806 VQLKLEGVPARPGDTVAMTITPPHDGQALVTVEGDRMLWSKWVPVQASG---TQVEIPVDKAWKRHDlYVSATVFRPgsq 882
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDGFTYLVLSKGQIVVVGRGgvtTSFSLPVTAEMAPSA-RVVAYYVRV--- 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 332383118 883 gDRVTPARALGLAFLPIASD-ERRLQVSLSaPAKTRPETRATVRVKVegaaGKAARVTLSAVDVGILNI 950
Cdd:pfam07703 77 -DLSKPEVVADSVWVDVDDTcENKLKVTLS-AEKYRPGSTVELKVKA----DPGAYVALAAVDKGVLLL 139
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
1018-1101 |
1.60e-13 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 67.61 E-value: 1.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1018 PVKLDDKGEADIALDLPDFNGTLRLMAVAFTADQ-FGSADR-EMTVAAPIVAELNTPRFITPGDQTAIALDVTNLSGATQ 1095
Cdd:pfam00207 6 PVLVTDNGKASLSFTLPDSITTWRATAFALSPDTgLGVAEPpELVVFKPFFVDLNLPYSVRRGEQFELKATVFNYLDKCL 85
|
....*.
gi 332383118 1096 KITVRL 1101
Cdd:pfam00207 86 KVRVRL 91
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1218-1358 |
5.06e-07 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 53.46 E-value: 5.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1218 VDGLLTYPYGCTEQTISAAIPWVLID---EAAAERFGLkVYSRADRESRvaSALGRLAGMRAANGSYSLWGDSSSrDVWL 1294
Cdd:pfam07678 19 LSSLLRLPYGCGEQNMVLFAPNVYVLrylDKTNQLTKL-IKSKAIDYLE--QGYQRQLSYKHPDGSYSAFGHSPG-STWL 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332383118 1295 TAYTVGFMQDVRDHEFNlAPALLERPRQWLLEQlQQASGGFGTWSPNLRRTLASGrfDENDAAI 1358
Cdd:pfam07678 95 TAFVLKVFAQARKFIFI-DPEEICQSLRWLLSQ-QKPDGSFREPGPLLHRAMKGG--VDGEVSL 154
|
|
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
1219-1335 |
2.08e-06 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 51.42 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332383118 1219 DGLLTYPYGCTEQTISAAIPWVLIDEAaaerfgLKVYSRADRESRvASALGRL-AG------MRAANGSYSLWGDSSSR- 1290
Cdd:cd02897 6 DNLLRMPYGCGEQNMVNFAPNIYVLDY------LKATGQLTPEIE-SKALGFLrTGyqrqltYKHSDGSYSAFGESDKSg 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 332383118 1291 DVWLTAYTV-GFMQdVRDHEFnLAPALLERPRQWLLEQlQQASGGF 1335
Cdd:cd02897 79 STWLTAFVLkSFAQ-ARPFIY-IDENVLQQALTWLSSH-QKSNGCF 121
|
|
| |
