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Conserved domains on  [gi|330414436|gb|AEC13627|]
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acetate kinase, partial [Leuconostoc mesenteroides]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-392 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 618.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   1 KLLEMPAEQVIAQGVIERIGMDDAIVTIKYGAeinaerlvghseddehitlskdgkGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:COG0282   16 QLFDMDSEEVLAKGLVERIGLPGARLKHKDAG------------------------GEKVERELPIPDHAAALALVLELL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  81 TDLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQ 160
Cdd:COG0282   72 TDHGIIKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQ 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 161 TMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPL 240
Cdd:COG0282  152 TMPEVAYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 241 AGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYV 319
Cdd:COG0282  232 EGLVMGTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEaAASGDERARLALDMFVYRIKKYI 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330414436 320 GQYVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:COG0282  312 GAYAAALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEEL 384
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-392 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 618.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   1 KLLEMPAEQVIAQGVIERIGMDDAIVTIKYGAeinaerlvghseddehitlskdgkGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:COG0282   16 QLFDMDSEEVLAKGLVERIGLPGARLKHKDAG------------------------GEKVERELPIPDHAAALALVLELL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  81 TDLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQ 160
Cdd:COG0282   72 TDHGIIKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQ 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 161 TMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPL 240
Cdd:COG0282  152 TMPEVAYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 241 AGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYV 319
Cdd:COG0282  232 EGLVMGTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEaAASGDERARLALDMFVYRIKKYI 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330414436 320 GQYVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:COG0282  312 GAYAAALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEEL 384
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-392 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 602.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   1 KLLEMPAEQVIAQGVIERIGMDDAIVTIKYGAeinaerlvghseddehitlskdgkGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:PRK00180  16 QLIDMPNEEVLASGLVERIGLPDSRIKIKVDG------------------------GEKEEEELPIPDHAEALKFLLNTL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  81 TD--LGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSF 158
Cdd:PRK00180  72 TDgkLGLIKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAF 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 159 HQTMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFS 238
Cdd:PRK00180 152 HQTMPEEAYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFT 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 239 PLAGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVK 317
Cdd:PRK00180 232 PLEGLVMGTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAaAEEGDERAKLALDVFVYRLAK 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330414436 318 YVGQYVAEM-GGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNN--VRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:PRK00180 312 YIGSYAAALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEEL 389
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 1-392 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 563.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   1 KLLEMPAEQVIAQGVIERIGMDDAIVTIKYGaeinaerlvghseddehitlskdgKGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:cd24010   14 QLFDMPTEEVLASGLVERIGLEGARLKHKVN------------------------NGEKIKEELPIPDHEEALKAILDTL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  81 TDLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQ 160
Cdd:cd24010   70 TDPELGVSLDEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQ 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 161 TMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPL 240
Cdd:cd24010  150 TMPPHAYLYALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 241 AGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYV 319
Cdd:cd24010  230 EGLVMGTRSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEaAEEGDERAKLALDVFVYRIKKYI 309

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 330414436 320 GQYVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVR-GKEVEISTNDSKVKALLIPTNQEL 392
Cdd:cd24010  310 GAYAAALGGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEEL 383
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-392 5.73e-168

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 474.99  E-value: 5.73e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436    2 LLEMPAEQVIAQGVIERIGMDDAIVTIKYGAeinaerlvghseddehitlskdgkGKKYENVTAIKNHQQAINFMLQKLT 81
Cdd:pfam00871  16 LFDAVIGEVLLSGLAERIGLPNARILWKMNG------------------------GKKNAALLAGADHSEALNFILNTLL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   82 DLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQT 161
Cdd:pfam00871  72 KHKIIELLAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  162 MPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPLA 241
Cdd:pfam00871 152 MPEEAYLYALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  242 GVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYVG 320
Cdd:pfam00871 232 GLVMGTRSGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDaYAEGKEDAQLAIKVYVHRLAKYIG 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330414436  321 QYVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:pfam00871 312 SYAASLERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEEL 383
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 2-392 3.66e-165

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 468.43  E-value: 3.66e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436    2 LLEMP-AEQVIAQGVIERIGMDDAIVTIKygaeinaerlvghseddehitlsKDGkGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:TIGR00016  20 LFDAVnGEEVLASGLAERIFLPNARIKWV-----------------------EDG-GKKEAELLAGADHQEALKFILNTL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   81 TDLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKL--LPDALSVAVFDTSF 158
Cdd:TIGR00016  76 LKDKIIKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLfpLPKAKNVAVFDTAF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  159 HQTMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFS 238
Cdd:TIGR00016 156 HQTMPEEAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  239 PLAGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVK 317
Cdd:TIGR00016 236 PLEGLMMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDaYAEGNEQAKLAIKVYVHRIAK 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330414436  318 YVGQYVAEMGG-VDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNN--VRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:TIGR00016 316 YIGSYIASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaaRSGKSGVISTPESKVKILVIPTNEEL 393
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-392 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 618.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   1 KLLEMPAEQVIAQGVIERIGMDDAIVTIKYGAeinaerlvghseddehitlskdgkGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:COG0282   16 QLFDMDSEEVLAKGLVERIGLPGARLKHKDAG------------------------GEKVERELPIPDHAAALALVLELL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  81 TDLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQ 160
Cdd:COG0282   72 TDHGIIKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQ 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 161 TMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPL 240
Cdd:COG0282  152 TMPEVAYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 241 AGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYV 319
Cdd:COG0282  232 EGLVMGTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEaAASGDERARLALDMFVYRIKKYI 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330414436 320 GQYVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:COG0282  312 GAYAAALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEEL 384
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-392 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 602.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   1 KLLEMPAEQVIAQGVIERIGMDDAIVTIKYGAeinaerlvghseddehitlskdgkGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:PRK00180  16 QLIDMPNEEVLASGLVERIGLPDSRIKIKVDG------------------------GEKEEEELPIPDHAEALKFLLNTL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  81 TD--LGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSF 158
Cdd:PRK00180  72 TDgkLGLIKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAF 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 159 HQTMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFS 238
Cdd:PRK00180 152 HQTMPEEAYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFT 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 239 PLAGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVK 317
Cdd:PRK00180 232 PLEGLVMGTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAaAEEGDERAKLALDVFVYRLAK 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330414436 318 YVGQYVAEM-GGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNN--VRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:PRK00180 312 YIGSYAAALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEEL 389
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 1-392 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 563.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   1 KLLEMPAEQVIAQGVIERIGMDDAIVTIKYGaeinaerlvghseddehitlskdgKGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:cd24010   14 QLFDMPTEEVLASGLVERIGLEGARLKHKVN------------------------NGEKIKEELPIPDHEEALKAILDTL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  81 TDLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQ 160
Cdd:cd24010   70 TDPELGVSLDEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQ 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 161 TMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPL 240
Cdd:cd24010  150 TMPPHAYLYALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 241 AGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYV 319
Cdd:cd24010  230 EGLVMGTRSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEaAEEGDERAKLALDVFVYRIKKYI 309

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 330414436 320 GQYVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVR-GKEVEISTNDSKVKALLIPTNQEL 392
Cdd:cd24010  310 GAYAAALGGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEEL 383
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-392 5.73e-168

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 474.99  E-value: 5.73e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436    2 LLEMPAEQVIAQGVIERIGMDDAIVTIKYGAeinaerlvghseddehitlskdgkGKKYENVTAIKNHQQAINFMLQKLT 81
Cdd:pfam00871  16 LFDAVIGEVLLSGLAERIGLPNARILWKMNG------------------------GKKNAALLAGADHSEALNFILNTLL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   82 DLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQT 161
Cdd:pfam00871  72 KHKIIELLAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  162 MPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPLA 241
Cdd:pfam00871 152 MPEEAYLYALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  242 GVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYVG 320
Cdd:pfam00871 232 GLVMGTRSGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDaYAEGKEDAQLAIKVYVHRLAKYIG 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330414436  321 QYVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:pfam00871 312 SYAASLERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEEL 383
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 2-392 3.66e-165

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 468.43  E-value: 3.66e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436    2 LLEMP-AEQVIAQGVIERIGMDDAIVTIKygaeinaerlvghseddehitlsKDGkGKKYENVTAIKNHQQAINFMLQKL 80
Cdd:TIGR00016  20 LFDAVnGEEVLASGLAERIFLPNARIKWV-----------------------EDG-GKKEAELLAGADHQEALKFILNTL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   81 TDLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKL--LPDALSVAVFDTSF 158
Cdd:TIGR00016  76 LKDKIIKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLfpLPKAKNVAVFDTAF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  159 HQTMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFS 238
Cdd:TIGR00016 156 HQTMPEEAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  239 PLAGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVK 317
Cdd:TIGR00016 236 PLEGLMMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDaYAEGNEQAKLAIKVYVHRIAK 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330414436  318 YVGQYVAEMGG-VDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNN--VRGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:TIGR00016 316 YIGSYIASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaaRSGKSGVISTPESKVKILVIPTNEEL 393
PRK12397 PRK12397
acetate/propionate family kinase;
1-392 2.13e-152

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 436.19  E-value: 2.13e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   1 KLLEMPAEQVIAQGVIERIGMDDAIVTIKYGAEinaerlvghseddehitlskdgkgkKYENVTAIKNHQQAINFMLQKL 80
Cdd:PRK12397  18 QLLEMPQGDMLCQGLIERIGMADAQVTIKTHSQ-------------------------KWQETVPVADHRDAVTLLLEKL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  81 TDLGIIKDFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQ 160
Cdd:PRK12397  73 LGYQIINSLRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 161 TMPDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPL 240
Cdd:PRK12397 153 TLDEPAYIYPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQ 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 241 AGVAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLDVQDT-NEHADMAIRIFINRVVKYV 319
Cdd:PRK12397 233 SGVMMGTRSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTgNRQAKLALTLFAERIRATI 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330414436 320 GQYVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNvrGKEVEISTNDSKVKALLIPTNQEL 392
Cdd:PRK12397 313 GSYIMQMGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQ--RNATFIQTENALVKVAVINTNEEL 383
PRK07157 PRK07157
acetate kinase; Provisional
 9-392 2.74e-125

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 367.14  E-value: 2.74e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   9 QVIAQGVIERIGMDDAIVTIKYGaeinaerlvghseddehitlskdgkGKKYENVTAIKNHQQAINFMLQKLTDLGIIKD 88
Cdd:PRK07157  26 NLIASGLAERIGLENGLIKIKFG-------------------------KKKYEKEVDMPNHKVAVAVLIEIWEENKLIED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  89 FNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQTMPDENFL 168
Cdd:PRK07157  81 LEEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINYT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 169 YALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDlkSLKLITLHLGAGASITAIKDGKSLDTSMGFSPLAGVAMATR 248
Cdd:PRK07157 161 YPINYEIAKKYGIKKYGFHGISHKFITNKVEKILNKD--KVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTR 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 249 SGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYVGQYVAEMG 327
Cdd:PRK07157 239 SGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKaAESGNKRAKFALDLYAQKIVDYLANYINKIG 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 328 G-VDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVRGKEVE----ISTNDSKVKALLIPTNQEL 392
Cdd:PRK07157 319 KkIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKIGEYGpielISTPDSDIPVYVIRTNEEL 388
PRK12379 PRK12379
propionate kinase;
3-391 3.96e-121

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 356.35  E-value: 3.96e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436   3 LEMPAEQVIAQGVIERIGMDDAIVTIKygaeinaerlvghseDDEHITLSKdgkgkkyenvtaiKNHQQAINFMLQKLTD 82
Cdd:PRK12379  22 LDASDCEVLMSGIADGINSENAFLSVN---------------GGEPAPLAH-------------HSYEGALKAIAFELEK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  83 LGIIKDFNEItgvGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQTM 162
Cdd:PRK12379  74 RNLNDSVALI---GHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 163 PDENFLYALPYEYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPLAG 242
Cdd:PRK12379 151 APEAYLYGLPWEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEG 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 243 VAMATRSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLDVQDT-NEHADMAIRIFINRVVKYVGQ 321
Cdd:PRK12379 231 LMMGTRSGDVDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEgHERAQLAIKTFVHRIARHIAG 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330414436 322 YVAEMGGVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNV--RGKEVEISTNDSKVKALLIPTNQE 391
Cdd:PRK12379 311 HAASLHRLDGIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQpnSGGERIISSENSRVICAVIPTNEE 382
PRK12440 PRK12440
acetate/propionate family kinase;
14-391 5.39e-109

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 325.28  E-value: 5.39e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  14 GVIERIGMDDAIVTIKYGAEINAERLVGhseDDEHitlskdgkgkkyenvtaiknHQQAINFMLQKLTDLGIIKDfneIT 93
Cdd:PRK12440  32 GLGECFGLEDARMSWKYQGEKTEIAIEG---EDNH--------------------HKIAIGRLVGLTEELGFTQD---IV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  94 GVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQTMPDENFLYALPY 173
Cdd:PRK12440  86 AVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFTGAIAK 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 174 EYYTRYGARKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPLAGVAMATRSGDVD 253
Cdd:PRK12440 166 ELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTRCGDLD 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 254 ASLVYYIQeREGLSNEEMLNILNKKSGLLGISTISSDMRDLLD-VQDTNEHADMAIRIFINRVVKYVGQYVAEMGGVDAI 332
Cdd:PRK12440 246 PGIIEFLL-KKGWSQEKVFNSLNKKSGFLGVSGLTSDARGILEaMEEGHEGATLAFEVFTYRVAKYIASYLAALDSLDGI 324

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330414436 333 VFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKN-NVR-GKEVEISTNDS-KVKALLIPTNQE 391
Cdd:PRK12440 325 IFTGGIGENSLPIRREILKNLKLLGFVEDEKGNeDARfGKAGIIAKSELlNAVAMVIPTNEE 386
PRK07058 PRK07058
acetate/propionate family kinase;
88-391 1.58e-91

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 280.78  E-value: 1.58e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436  88 DFNEITGVGHRVVAGGEWFNHSVVVTDEVLAKIDRLADYAPLHNPANAMGIRAFQKLLPDALSVAVFDTSFHQTMPDENF 167
Cdd:PRK07058  82 DVSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPDLVR 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 168 LYALPYEYYTRyGARKYGAHGTSHRYVASRAAELlGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMGFSPLAGVAMAT 247
Cdd:PRK07058 162 RFAIPRALHDE-GIKRYGFHGLSYKFVAGELRRR-APELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGIPMAT 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 248 RSGDVDASLVYYIQEREGLSNEEMLNILNKKSGLLGISTISSDMRDLLdvQDTNEHADMAIRIFINRVVKYVGQYVAEMG 327
Cdd:PRK07058 240 RCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLL--ASDAPEAREALDLFALRIAGEIARLAATLG 317

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 330414436 328 GVDAIVFTAGIGENSVPVRKMIIDKLNYFGVKLDEEKNNVRGKevEISTNDSKVKALLIPTNQE 391
Cdd:PRK07058 318 GLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAANAF--TISSRTSRVAAFVIPTDEE 379
PRK03011 PRK03011
butyrate kinase; Provisional
 182-357 9.30e-21

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 92.53  E-value: 9.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 182 RKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMG------FSPLagvamatRSGDVDAS 255
Cdd:PRK03011 149 RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSPE-------RAGGLPVG 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 256 -LVYYIQEREgLSNEEMLNILNKKSGL---LGistiSSDMRDLLD-VQDTNEHADMAIRIFINRVVKYVG-QYVAEMGGV 329
Cdd:PRK03011 222 dLVELCFSGK-YTKEELKKKLVGKGGLvayLG----TNDAREVEKrIEEGDEKAKLVYEAMAYQIAKEIGaMAAVLKGKV 296

                        170       180
                 ....*....|....*....|....*...
gi 330414436 330 DAIVFTAGIgENSVPVRKMIIDKLNYFG 357
Cdd:PRK03011 297 DAIVLTGGL-AYSKRLVERIKERVSFIA 323
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 182-357 6.05e-20

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 89.90  E-value: 6.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 182 RKYGAHGTSHRYVASRAAELLGKDLKSLKLITLHLGAGASITAIKDGKSLDTSMG------FSPlagvamaTRSGDVDAS 255
Cdd:cd24011  147 RRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSP-------ERAGTLPVG 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330414436 256 LVYYIQEREGLSNEEMLNILNKKSGL---LGIstisSDMRDLLD-VQDTNEHADMAIRIFINRVVKYVGQYVAEMGG-VD 330
Cdd:cd24011  220 DLIKLCFSGKYTLEELKKKLKGKGGLvayLGT----NDFREVEKrIEAGDEKAKLVLDAMAYQIAKEIGALAAVLKGkVD 295

                        170       180
                 ....*....|....*....|....*..
gi 330414436 331 AIVFTAGIGeNSVPVRKMIIDKLNYFG 357
Cdd:cd24011  296 AIILTGGLA-YSKRLVDRIKERVGFIA 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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