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Conserved domains on  [gi|324312893|gb|ADY33446|]
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OmpA/MotB domain protein [Odoribacter splanchnicus DSM 20712]

Protein Classification

OmpA family protein( domain architecture ID 11458387)

OmpA family membrane protein acts as a porin with low permeability that allows slow penetration of small solutes

CATH:  3.30.1330.60
PubMed:  22986056
SCOP:  4001470
TCDB:  1.B.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 91-366 7.24e-23

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 97.16  E-value: 7.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893  91 RDYKFNFLQLNADVVFNLSNCIGEFNPRRWVNTYFLLGIAGNHAFDNDEAVAIHDEGYTMRYLWRDNRNFVAGRGGVGFD 170
Cdd:COG2885   14 DAAGGLLSGAALLLALLGVLGSAGGLLSLADDLAEASAGAAGGAAAGAEAGGLSAGLELLDAGSLSATAAAGAAALLVLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 171 FRISNSISFNIEGNVNVLSDHFNSKKAGNADWQFNVLAGFSCRLNKKHRKVEAPREIIFEETVPVVTKEEPVSQPVLQET 250
Cdd:COG2885   94 AALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAKALGDSAAAALDAAAKAEAAAAAA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 251 KQDLIDSAALTARQDIFFALNSSVILASETAKIDSLVAFMKTHTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLT 330
Cdd:COG2885  174 ALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTD-SRGSDAYNLALSERRAEAVKDYLV 252

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 324312893 331 VNGISRERITVFAKGDTEqpfPV--------MEQN-RVAICLIGK 366
Cdd:COG2885  253 SKGIPASRITAVGYGESR---PVasndteegRAKNrRVEIVVLKK 294
 
Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 91-366 7.24e-23

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 97.16  E-value: 7.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893  91 RDYKFNFLQLNADVVFNLSNCIGEFNPRRWVNTYFLLGIAGNHAFDNDEAVAIHDEGYTMRYLWRDNRNFVAGRGGVGFD 170
Cdd:COG2885   14 DAAGGLLSGAALLLALLGVLGSAGGLLSLADDLAEASAGAAGGAAAGAEAGGLSAGLELLDAGSLSATAAAGAAALLVLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 171 FRISNSISFNIEGNVNVLSDHFNSKKAGNADWQFNVLAGFSCRLNKKHRKVEAPREIIFEETVPVVTKEEPVSQPVLQET 250
Cdd:COG2885   94 AALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAKALGDSAAAALDAAAKAEAAAAAA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 251 KQDLIDSAALTARQDIFFALNSSVILASETAKIDSLVAFMKTHTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLT 330
Cdd:COG2885  174 ALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTD-SRGSDAYNLALSERRAEAVKDYLV 252

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 324312893 331 VNGISRERITVFAKGDTEqpfPV--------MEQN-RVAICLIGK 366
Cdd:COG2885  253 SKGIPASRITAVGYGESR---PVasndteegRAKNrRVEIVVLKK 294
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 263-358 1.98e-21

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 87.99  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 263 RQDIFFALNSSVILASETAKIDSLVAFMKTHTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLTVNGISRERITVF 342
Cdd:cd07185    1 LITIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTD-SRGSDAYNQELSERRAEAVADYLVSKGVDASRITAV 79

                         90       100
                 ....*....|....*....|....
gi 324312893 343 AKGDTEqpfPV--------MEQNR 358
Cdd:cd07185   80 GYGESR---PIasndteegRAKNR 100
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 268-348 5.28e-12

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 61.61  E-value: 5.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893  268 FALNSSVILASETAKIDSLVAFMK-THTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLTVNGISRERITVFAKGD 346
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKfPELKNTITIEGHTD-TVGSAAYNWELSQRRAEAVRRYLVNFGVPPSRISVVGYGA 79


                  ..
gi 324312893  347 TE 348
Cdd:pfam00691  80 TK 81
PRK10802 PRK10802
peptidoglycan-associated lipoprotein Pal;
266-350 5.52e-07

peptidoglycan-associated lipoprotein Pal;


Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 49.10  E-value: 5.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 266 IFFALNSSVILASETAKIDSLVAFMKTHTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLTVNGISRERITVFAKG 345
Cdd:PRK10802  71 VYFDLDKYDIRSDFAQMLDAHANFLRSNPSYKVTVEGHAD-ERGTPEYNIALGERRANAVKMYLQGKGVSADQISIVSYG 149


                 ....*
gi 324312893 346 dTEQP 350
Cdd:PRK10802 150 -KEKP 153
 
Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 91-366 7.24e-23

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 97.16  E-value: 7.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893  91 RDYKFNFLQLNADVVFNLSNCIGEFNPRRWVNTYFLLGIAGNHAFDNDEAVAIHDEGYTMRYLWRDNRNFVAGRGGVGFD 170
Cdd:COG2885   14 DAAGGLLSGAALLLALLGVLGSAGGLLSLADDLAEASAGAAGGAAAGAEAGGLSAGLELLDAGSLSATAAAGAAALLVLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 171 FRISNSISFNIEGNVNVLSDHFNSKKAGNADWQFNVLAGFSCRLNKKHRKVEAPREIIFEETVPVVTKEEPVSQPVLQET 250
Cdd:COG2885   94 AALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAKALGDSAAAALDAAAKAEAAAAAA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 251 KQDLIDSAALTARQDIFFALNSSVILASETAKIDSLVAFMKTHTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLT 330
Cdd:COG2885  174 ALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTD-SRGSDAYNLALSERRAEAVKDYLV 252

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 324312893 331 VNGISRERITVFAKGDTEqpfPV--------MEQN-RVAICLIGK 366
Cdd:COG2885  253 SKGIPASRITAVGYGESR---PVasndteegRAKNrRVEIVVLKK 294
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 263-358 1.98e-21

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 87.99  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 263 RQDIFFALNSSVILASETAKIDSLVAFMKTHTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLTVNGISRERITVF 342
Cdd:cd07185    1 LITIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTD-SRGSDAYNQELSERRAEAVADYLVSKGVDASRITAV 79

                         90       100
                 ....*....|....*....|....
gi 324312893 343 AKGDTEqpfPV--------MEQNR 358
Cdd:cd07185   80 GYGESR---PIasndteegRAKNR 100
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 268-348 5.28e-12

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 61.61  E-value: 5.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893  268 FALNSSVILASETAKIDSLVAFMK-THTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLTVNGISRERITVFAKGD 346
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKfPELKNTITIEGHTD-TVGSAAYNWELSQRRAEAVRRYLVNFGVPPSRISVVGYGA 79


                  ..
gi 324312893  347 TE 348
Cdd:pfam00691  80 TK 81
PRK10802 PRK10802
peptidoglycan-associated lipoprotein Pal;
266-350 5.52e-07

peptidoglycan-associated lipoprotein Pal;


Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 49.10  E-value: 5.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 266 IFFALNSSVILASETAKIDSLVAFMKTHTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLTVNGISRERITVFAKG 345
Cdd:PRK10802  71 VYFDLDKYDIRSDFAQMLDAHANFLRSNPSYKVTVEGHAD-ERGTPEYNIALGERRANAVKMYLQGKGVSADQISIVSYG 149


                 ....*
gi 324312893 346 dTEQP 350
Cdd:PRK10802 150 -KEKP 153
PRK08126 PRK08126
hypothetical protein; Provisional
 257-358 4.41e-06

hypothetical protein; Provisional


Pssm-ID: 236157 [Multi-domain]  Cd Length: 432  Bit Score: 48.15  E-value: 4.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 257 SAALTARQDIFFALNSSVILASET---AKIDSLVAfmktHTETQVVITGYADVQTGNPRY---NKVLSQRRAEQVAVLLT 330
Cdd:PRK08126 316 HSSVVFRGDAMFVPGQATVNPAMGpliAKIAREIA----RVGGKVTVTGHTDNQPIRSAQfasNLVLSEKRAAQVAQMLQ 391

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 324312893 331 VNGISRERITVFAKGDTEqpfPVME--------QNR 358
Cdd:PRK08126 392 SAGVPASRLEAVGKGDAQ---PVADnrtpqgraQNR 424
MotB COG1360
Flagellar motor protein MotB [Cell motility];
265-358 5.25e-06

Flagellar motor protein MotB [Cell motility];


Pssm-ID: 440971 [Multi-domain]  Cd Length: 174  Bit Score: 46.38  E-value: 5.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 265 DIFFALNSSVILASETAKIDSLVAFMKTHTEtQVVITGYAD-VQTGNPRY--NKVLSQRRAEQVAVLLTVNGISRERITV 341
Cdd:COG1360   60 RVLFDSGSAELTPEGRELLDKIAAVLAEVPN-RIRVEGHTDnVPISTARFpsNWELSAARAAAVVRYLIEGGVPPERLSA 138

                         90       100
                 ....*....|....*....|...
gi 324312893 342 FAKGDTeQPF------PVMEQNR 358
Cdd:COG1360  139 VGYGDT-RPLapndtpEGRARNR 160
PRK10808 PRK10808
outer membrane protein A; Reviewed
 230-345 5.93e-06

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 47.76  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 230 EETVPVVTKEePVSQPVLQeTKQdlidsaaLTARQDIFFALNSSVILASETAKIDSLVAFMKTHTETQ--VVITGYADvQ 307
Cdd:PRK10808 199 EEAAPVVAPA-PAPAPVVQ-TKH-------FTLKSDVLFNFNKATLKPEGQQALDQLYSQLSNLDPKDgsVVVLGYTD-R 268

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 324312893 308 TGNPRYNKVLSQRRAEQVAVLLTVNGISRERITVFAKG 345
Cdd:PRK10808 269 IGSDAYNQGLSEKRAQSVVDYLVSKGIPADKISARGMG 306
PRK10510 PRK10510
OmpA family lipoprotein;
256-345 9.59e-05

OmpA family lipoprotein;


Pssm-ID: 182507 [Multi-domain]  Cd Length: 219  Bit Score: 43.32  E-value: 9.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 256 DSAALTARQDIFFALNSSVILASETAKIDSLVAFMKTHTETQVVITGYADvQTGNPRYNKVLSQRRAEQVAVLLTVNGIS 335
Cdd:PRK10510 104 DNIILNMPNNVTFDSSSATLKPAGANTLTGVAMVLKEYPKTAVNVVGYTD-STGSHDLNMRLSQQRADSVASALITQGVD 182

                         90
                 ....*....|
gi 324312893 336 RERITVFAKG 345
Cdd:PRK10510 183 ASRIRTQGMG 192
OMP_b-brl pfam13505
Outer membrane protein beta-barrel domain; This domain is found in a wide range of outer ...
 4-206 1.07e-04

Outer membrane protein beta-barrel domain; This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.


Pssm-ID: 463903 [Multi-domain]  Cd Length: 175  Bit Score: 42.39  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893    4 SLLLAIVLFCAEilfAQKGKEEAGiifnphWYLQlqGGMGYT-VGETGFKDLISPAGALSVGYQFSPVWGLRGGFGGWQG 82
Cdd:pfam13505   1 AALLLLAAFSAA---AAAAEEFGG------FYVG--GGLGNAnFSFDGDGTDSGGGFGVGAGYDFNDYLGVEGELGYGSD 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893   83 KGAWSESTRDYKFNFLQLNADVVFNlsncigeFNPRRWVNTYFLLGIAGnhafdNDEAVAIHDEGYTmrylwrdnRNFVA 162
Cdd:pfam13505  70 DDYSGGGNTDANIRSLSIGVNLGYR-------FPLSDSLLPYGGAGYGY-----SKLEGDYNGVSDS--------GTDFG 129

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 324312893  163 GRGGVGFDFRISNSISFNIEGNVNVLSDHFNSKKAGNadWQFNV 206
Cdd:pfam13505 130 FGYGAGVEYALTDHLAVRAEYRYTDIKSGGDDLKNNT--FQLGV 171
PRK07033 PRK07033
DotU family type VI secretion system protein;
206-348 1.32e-04

DotU family type VI secretion system protein;


Pssm-ID: 180801 [Multi-domain]  Cd Length: 427  Bit Score: 43.50  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 206 VLAGFSCRLNKKHRKVEAPreiIFEETVPVVTKEEPVSQPVLQE---------------TKQDLIDSAALTARQDIFFAL 270
Cdd:PRK07033 244 LFIGLRWRLADRSDPVFAA---IYALRLPVVQIARPAPQPPPAPrlakflepeiraglvAVRDEADRSVVTLRGDGLFAS 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 271 NSSVILASETAKIDSLVAFMKThTETQVVITGYAD-VQTGNPRY--NKVLSQRRAEQVAVLLTVNGISRERITVFAKGDT 347
Cdd:PRK07033 321 ASTSVRDRYQPVLARVADALNQ-VKGNVLVTGYSDnVPIRTARFpsNWELSQARAQAVRALLAARLGQPERVTAEGRGDS 399


                 .
gi 324312893 348 E 348
Cdd:PRK07033 400 D 400
motB PRK08457
flagellar motor protein MotB; Reviewed
 238-361 2.76e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 181435 [Multi-domain]  Cd Length: 257  Bit Score: 42.01  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324312893 238 KEEPVSQPVLQETKQDLIDS-----AALTARQD-IFFALNSSVILASETAKIDS--LVAFMKTHTE--------TQVVIT 301
Cdd:PRK08457  82 MDELKSLKASQNTQQETIERrkgegGALDQIDNgIALKLPSKLLFENGSAEIINadMMDYLKRIAKiitklpkqVKINVR 161

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 324312893 302 GYADVQTGN-PRY--NKVLSQRRAEQVAVLLTVNGISRERITVFAKGDTEQPFPV------MEQNRVAI 361
Cdd:PRK08457 162 GYTDNSPLNkSRYkdHYELAAARAYNVMKVLIQYGINPNRLSFSSYGSNNPIAPNdslenrLKNNRVEI 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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