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Conserved domains on  [gi|312444180|gb|ADQ80536|]
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OmpA/MotB domain protein [Paludibacter propionicigenes WB4]

Protein Classification

OmpA family protein( domain architecture ID 11458388)

OmpA family membrane protein may act as a porin with low permeability that allows slow penetration of small solutes, similar to outer membrane protein A (OmpA) and outer membrane porin F (OprF) as well as the flagellar protein MotY which may act as a stator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 337-436 3.72e-20

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


:

Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 84.91  E-value: 3.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 337 TVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKMwKIPSDHIIVNGK 416
Cdd:cd07185    3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSK-GVDASRITAVGY 81

                         90       100
                 ....*....|....*....|....*.
gi 312444180 417 GKiIEPRVR------YRPNRRCDFFF 436
Cdd:cd07185   82 GE-SRPIASndteegRAKNRRVEIVI 106
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 222-439 6.05e-20

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 89.84  E-value: 6.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 222 LRNIRMNEFSPDEGLALATLNSDRINKLDKELKKLDKKVDNQGRKIDSIARFLSNDGPDSDGDGVPDVRDNDPHTPPNTP 301
Cdd:COG2885   73 LDAGSLSATAAAGAAALLVLLAALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAKAL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 302 VDFWGKPMKNIVINSNSSSVNNSKSNGNNGFDDTPTVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGK 381
Cdd:COG2885  153 GDSAAAALDAAAKAEAAAAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTDSRGS 232

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312444180 382 NPYNETLSKKRAERVKAELVKMwKIPSDHIIVNGKGKiIEPRVR------YRPNRRCDFFFDKQ 439
Cdd:COG2885  233 DAYNLALSERRAEAVKDYLVSK-GIPASRITAVGYGE-SRPVASndteegRAKNRRVEIVVLKK 294
 
Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 337-436 3.72e-20

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 84.91  E-value: 3.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 337 TVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKMwKIPSDHIIVNGK 416
Cdd:cd07185    3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSK-GVDASRITAVGY 81

                         90       100
                 ....*....|....*....|....*.
gi 312444180 417 GKiIEPRVR------YRPNRRCDFFF 436
Cdd:cd07185   82 GE-SRPIASndteegRAKNRRVEIVI 106
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 222-439 6.05e-20

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 89.84  E-value: 6.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 222 LRNIRMNEFSPDEGLALATLNSDRINKLDKELKKLDKKVDNQGRKIDSIARFLSNDGPDSDGDGVPDVRDNDPHTPPNTP 301
Cdd:COG2885   73 LDAGSLSATAAAGAAALLVLLAALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAKAL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 302 VDFWGKPMKNIVINSNSSSVNNSKSNGNNGFDDTPTVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGK 381
Cdd:COG2885  153 GDSAAAALDAAAKAEAAAAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTDSRGS 232

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312444180 382 NPYNETLSKKRAERVKAELVKMwKIPSDHIIVNGKGKiIEPRVR------YRPNRRCDFFFDKQ 439
Cdd:COG2885  233 DAYNLALSERRAEAVKDYLVSK-GIPASRITAVGYGE-SRPVASndteegRAKNRRVEIVVLKK 294
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 340-418 3.98e-11

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 59.30  E-value: 3.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180  340 FDFDRIDLDNDALETISKIAFKMKA-DPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKMwKIPSDHIIVNGKGK 418
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKFpELKNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNF-GVPPSRISVVGYGA 79
Pal_lipo TIGR02802
peptidoglycan-associated lipoprotein; Members of this protein are Pal (also called OprL), the ...
 337-403 4.98e-08

peptidoglycan-associated lipoprotein; Members of this protein are Pal (also called OprL), the Peptidoglycan-Associated Lipoprotein of the Tol-Pal system. The system appears to be involved both in the maintenance of outer membrane integrity and in the import of certain organic molecules as nutrients. Members of this family contain a hydrodrophobic lipoprotein signal sequence, a conserved N-terminal cleavage and modification site, a poorly conserved low-complexity region, together comprising about 65 amino acids, and a well-conserved C-terminal domain. The seed alignment for this model includes only the conserved C-terminal domain.


Pssm-ID: 274307 [Multi-domain]  Cd Length: 104  Bit Score: 50.64  E-value: 4.98e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 312444180  337 TVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKM 403
Cdd:TIGR02802   1 RVYFDFDSSDLKSEAQATLDAHAQYLKKNPSVRVTIEGHTDERGTREYNLALGERRANAVKDYLQSK 67
PRK10802 PRK10802
peptidoglycan-associated lipoprotein Pal;
338-431 7.62e-06

peptidoglycan-associated lipoprotein Pal;


Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 46.02  E-value: 7.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 338 VYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELvKMWKIPSDHI-IVN-G 415
Cdd:PRK10802  71 VYFDLDKYDIRSDFAQMLDAHANFLRSNPSYKVTVEGHADERGTPEYNIALGERRANAVKMYL-QGKGVSADQIsIVSyG 149

                         90       100
                 ....*....|....*....|..
gi 312444180 416 KGKiiePRV------RYRPNRR 431
Cdd:PRK10802 150 KEK---PAVlghdeaAYAKNRR 168
 
Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 337-436 3.72e-20

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 84.91  E-value: 3.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 337 TVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKMwKIPSDHIIVNGK 416
Cdd:cd07185    3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSK-GVDASRITAVGY 81

                         90       100
                 ....*....|....*....|....*.
gi 312444180 417 GKiIEPRVR------YRPNRRCDFFF 436
Cdd:cd07185   82 GE-SRPIASndteegRAKNRRVEIVI 106
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 222-439 6.05e-20

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 89.84  E-value: 6.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 222 LRNIRMNEFSPDEGLALATLNSDRINKLDKELKKLDKKVDNQGRKIDSIARFLSNDGPDSDGDGVPDVRDNDPHTPPNTP 301
Cdd:COG2885   73 LDAGSLSATAAAGAAALLVLLAALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAKAL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 302 VDFWGKPMKNIVINSNSSSVNNSKSNGNNGFDDTPTVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGK 381
Cdd:COG2885  153 GDSAAAALDAAAKAEAAAAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTDSRGS 232

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312444180 382 NPYNETLSKKRAERVKAELVKMwKIPSDHIIVNGKGKiIEPRVR------YRPNRRCDFFFDKQ 439
Cdd:COG2885  233 DAYNLALSERRAEAVKDYLVSK-GIPASRITAVGYGE-SRPVASndteegRAKNRRVEIVVLKK 294
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 340-418 3.98e-11

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 59.30  E-value: 3.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180  340 FDFDRIDLDNDALETISKIAFKMKA-DPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKMwKIPSDHIIVNGKGK 418
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKFpELKNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNF-GVPPSRISVVGYGA 79
Pal_lipo TIGR02802
peptidoglycan-associated lipoprotein; Members of this protein are Pal (also called OprL), the ...
 337-403 4.98e-08

peptidoglycan-associated lipoprotein; Members of this protein are Pal (also called OprL), the Peptidoglycan-Associated Lipoprotein of the Tol-Pal system. The system appears to be involved both in the maintenance of outer membrane integrity and in the import of certain organic molecules as nutrients. Members of this family contain a hydrodrophobic lipoprotein signal sequence, a conserved N-terminal cleavage and modification site, a poorly conserved low-complexity region, together comprising about 65 amino acids, and a well-conserved C-terminal domain. The seed alignment for this model includes only the conserved C-terminal domain.


Pssm-ID: 274307 [Multi-domain]  Cd Length: 104  Bit Score: 50.64  E-value: 4.98e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 312444180  337 TVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKM 403
Cdd:TIGR02802   1 RVYFDFDSSDLKSEAQATLDAHAQYLKKNPSVRVTIEGHTDERGTREYNLALGERRANAVKDYLQSK 67
PRK10802 PRK10802
peptidoglycan-associated lipoprotein Pal;
338-431 7.62e-06

peptidoglycan-associated lipoprotein Pal;


Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 46.02  E-value: 7.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 338 VYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELvKMWKIPSDHI-IVN-G 415
Cdd:PRK10802  71 VYFDLDKYDIRSDFAQMLDAHANFLRSNPSYKVTVEGHADERGTPEYNIALGERRANAVKMYL-QGKGVSADQIsIVSyG 149

                         90       100
                 ....*....|....*....|..
gi 312444180 416 KGKiiePRV------RYRPNRR 431
Cdd:PRK10802 150 KEK---PAVlghdeaAYAKNRR 168
PRK10808 PRK10808
outer membrane protein A; Reviewed
 338-418 1.68e-05

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 46.61  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 338 VYFDFDRIDLD---NDALETI-SKIAfkmKADPSL-YVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKMwKIPSDHII 412
Cdd:PRK10808 226 VLFNFNKATLKpegQQALDQLySQLS---NLDPKDgSVVVLGYTDRIGSDAYNQGLSEKRAQSVVDYLVSK-GIPADKIS 301


                 ....*.
gi 312444180 413 VNGKGK 418
Cdd:PRK10808 302 ARGMGK 307
PRK09967 PRK09967
OmpA family protein;
337-418 7.28e-05

OmpA family protein;


Pssm-ID: 182172 [Multi-domain]  Cd Length: 160  Bit Score: 43.04  E-value: 7.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312444180 337 TVYFDFDRIDLDNDALETISKIAFKMKADPSLYVEVRGYCDYLGKNPYNETLSKKRAERVKAELVKMWKIPSDHIIVNGK 416
Cdd:PRK09967  53 AILFAKNDYKLLPESQQQIQTMAAKLASTGLTHARMDGHTDNYGEDSYNEGLSLKRANVVADAWAMGGQIPRSNLTTQGL 132


                 ..
gi 312444180 417 GK 418
Cdd:PRK09967 133 GK 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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