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Conserved domains on  [gi|311778175|gb|ADQ07661|]
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binding-protein-dependent transport systems inner membrane component [Caldicellulosiruptor hydrothermalis 108]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
17-306 1.35e-89

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 269.31  E-value: 1.35e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  17 RRKRSMKEIWEFVLLVSPTFILLTSFVFLPFLKTLYTSFCITDFNANVKKFVGFANYINLLTSPDFLNSLLVTSKYVVVN 96
Cdd:COG1175    9 ARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  97 TMFSIVGGLVLALSVDNNKYFKKFFKISFTLPISLSSASAAIVWGILFNPTVSIINYVLESFCFSKIEWLTDPKVALYSI 176
Cdd:COG1175   89 VPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDPSLALPAV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 177 VLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSFQQFTVVHILTRGGP 256
Cdd:COG1175  169 IIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGP 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 311778175 257 VNSTKFLVYLIYQDAFFNFKFAQACAESIILFVLLLLLTIIQFKVLEKKV 306
Cdd:COG1175  249 GNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
17-306 1.35e-89

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 269.31  E-value: 1.35e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  17 RRKRSMKEIWEFVLLVSPTFILLTSFVFLPFLKTLYTSFCITDFNANVKKFVGFANYINLLTSPDFLNSLLVTSKYVVVN 96
Cdd:COG1175    9 ARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  97 TMFSIVGGLVLALSVDNNKYFKKFFKISFTLPISLSSASAAIVWGILFNPTVSIINYVLESFCFSKIEWLTDPKVALYSI 176
Cdd:COG1175   89 VPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDPSLALPAV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 177 VLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSFQQFTVVHILTRGGP 256
Cdd:COG1175  169 IIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGP 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 311778175 257 VNSTKFLVYLIYQDAFFNFKFAQACAESIILFVLLLLLTIIQFKVLEKKV 306
Cdd:COG1175  249 GNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
30-309 5.45e-41

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 143.81  E-value: 5.45e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  30 LLVSPTFILLTSFVFLPFLKTLYTSFCITDFNANVKKFVGFANYINLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLAL 109
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 110 SVDNNKYFKKFFKISFTLPISLSSASAAIVWGILFNPTVSIINYVLESFCFSkIEWLTDPKVALYSIVLINAWQNIPFNF 189
Cdd:PRK10561  81 LVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYD-WNHAQNSGQAMFLVVFASVWKQISYNF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 190 LFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDS-FQQFTVVHILTRGGPVNSTKFLVYLIY 268
Cdd:PRK10561 160 LFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSGGPVQATTTLIYKIY 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 311778175 269 QDAFFNFKFAQACAESIILFVLLLLLTIIQFKVLEKKVFYQ 309
Cdd:PRK10561 240 REGFTGLDLSSSAAQSVVLMFLVIVLTVVQFRYVESKVRYQ 280
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 82-275 3.41e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 58.44  E-value: 3.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  82 FLNSLLVTSKYVVVNTMFSIVGGLVLALsvdNNKYFKKFFKISFTLPISLSSASAAIVWGILFNPtvsiinyvlesfcfs 161
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILAR---KRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGV--------------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 162 KIEWLTDPKVALYSIVLINAWQnIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDS 241
Cdd:cd06261   63 LLGWGILPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARA 141

                        170       180       190
                 ....*....|....*....|....*....|....
gi 311778175 242 FQQFTVVHILTrGGPVNSTKFLVYLIYQDAFFNF 275
Cdd:cd06261  142 LGEFALVSFLG-GGEAPGPGTGLLLIFAILFPGD 174
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 163-280 6.54e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 54.61  E-value: 6.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  163 IEWLTDPKVALYSIVLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSF 242
Cdd:pfam00528  42 IAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGAL 121

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 311778175  243 QQFTVVHILTRGGPVNSTKFLVYLIYQDAFFNFKFAQA 280
Cdd:pfam00528 122 GGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAA 159
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 37-272 8.42e-06

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 46.98  E-value: 8.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175   37 ILLTSFVFLPFLKTLYTSFCITDfnanvKKFVGFANYINLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLALSVD-NNK 115
Cdd:TIGR03262  12 LALLLFLLLPLLALLTKSVYDSD-----GDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTrSRI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  116 YFKKFFKISFTLPI---SLSSASAAIVW----GILfnptvsiinyvlesfcfskIEWLTDPKV-ALYSIVLINAWQNIPF 187
Cdd:TIGR03262  87 PGKGAFRLVALLPLlapSLLPAISLIYLfgnqGLL-------------------KGLLGGFSIyGFWGIVIGEVFYTFPH 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  188 NFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSFQQFTVVHILTRGGPVNSTKFLVYLI 267
Cdd:TIGR03262 148 ALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKVIGGDYNVLATDIYKQVI 227


                  ....*
gi 311778175  268 YQDAF 272
Cdd:TIGR03262 228 GQQNF 232
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
17-306 1.35e-89

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 269.31  E-value: 1.35e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  17 RRKRSMKEIWEFVLLVSPTFILLTSFVFLPFLKTLYTSFCITDFNANVKKFVGFANYINLLTSPDFLNSLLVTSKYVVVN 96
Cdd:COG1175    9 ARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  97 TMFSIVGGLVLALSVDNNKYFKKFFKISFTLPISLSSASAAIVWGILFNPTVSIINYVLESFCFSKIEWLTDPKVALYSI 176
Cdd:COG1175   89 VPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDPSLALPAV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 177 VLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSFQQFTVVHILTRGGP 256
Cdd:COG1175  169 IIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGP 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 311778175 257 VNSTKFLVYLIYQDAFFNFKFAQACAESIILFVLLLLLTIIQFKVLEKKV 306
Cdd:COG1175  249 GNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
30-309 5.45e-41

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 143.81  E-value: 5.45e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  30 LLVSPTFILLTSFVFLPFLKTLYTSFCITDFNANVKKFVGFANYINLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLAL 109
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 110 SVDNNKYFKKFFKISFTLPISLSSASAAIVWGILFNPTVSIINYVLESFCFSkIEWLTDPKVALYSIVLINAWQNIPFNF 189
Cdd:PRK10561  81 LVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYD-WNHAQNSGQAMFLVVFASVWKQISYNF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 190 LFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDS-FQQFTVVHILTRGGPVNSTKFLVYLIY 268
Cdd:PRK10561 160 LFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSGGPVQATTTLIYKIY 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 311778175 269 QDAFFNFKFAQACAESIILFVLLLLLTIIQFKVLEKKVFYQ 309
Cdd:PRK10561 240 REGFTGLDLSSSAAQSVVLMFLVIVLTVVQFRYVESKVRYQ 280
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 1-239 1.48e-24

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 100.94  E-value: 1.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175   1 MEYAYEKELVGIKVKKRRKRS-MKEIWEFVLLVSPTFILLTSFVFLPFLKtLYTSFciTDFNANVK----KFVGFANYIN 75
Cdd:COG4209    1 MSTTAAKAKRKKKKRKKSFLKrLKRDWQLYLMLLPGLIYLLIFSYLPMYG-IVIAF--KDYNPFKGifgsPWVGLKNFKF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  76 LLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLALSVDN--NKYFKKFFKISFTLPISLSSASAAIVWGILFNPTVSIINY 153
Cdd:COG4209   78 LFSSPDFWRVLRNTLLISLLKLVFGFPLPIILALLLNElrSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 154 VLESFCFSKIEWLTDPKVALYSIVLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPslffT 233
Cdd:COG4209  158 LLRALGGEPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRP----T 233


                 ....*.
gi 311778175 234 LVINVI 239
Cdd:COG4209  234 IVILLI 239
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
30-280 3.27e-20

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 90.61  E-value: 3.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  30 LLVSPTFILLTSFVFLPFLKTLYTSFcitdfnanvkkFVGFANYINLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLAL 109
Cdd:COG1178   11 LLLLLLALLLALLVLLPLLALLLRAF-----------TDGLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 110 SVDN-NKYFKKFFKISFTLPISLSSASAAIVWGILFNPTvSIINYVLEsfcfskiEWLTDPKVALYS---IVLINAWQNI 185
Cdd:COG1178   80 LLARtDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPN-GLLNTLLR-------ALFGLEPPDIYGlggIILVLVLFNY 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 186 PFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSFQQFTVVHILtrGGPVNStkfLVY 265
Cdd:COG1178  152 PYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL--GGGYTT---LTT 226

                        250
                 ....*....|....*
gi 311778175 266 LIYQDAFFNFKFAQA 280
Cdd:COG1178  227 AIYQAWLGDFDLGAA 241
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 19-282 4.60e-17

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 79.42  E-value: 4.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  19 KRSMKEIWEFVLLVSPTFILLTSFVFLPFLKTLYTSFCITDFNANVKKFVGFANYINLLTSPDFLNSLLVTSKYVVVNTM 98
Cdd:COG1176    2 SAALRRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGFTLENYARLFTDPLYLKVLLRTLWIALLTTL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  99 FSIVGGLVLALSVDN-NKYFKKFFKISFTLPISLSSASAAIVWGILFNPTvSIINYVLESFcfskieWLTDPKVALY--- 174
Cdd:COG1176   82 ICLLLGYPIAYFLARaPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRN-GLLNSLLLAL------GLIDEPLRLLyte 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 175 -SIVLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSFQQFTVVHILtr 253
Cdd:COG1176  155 fAVVIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALL-- 232

                        250       260
                 ....*....|....*....|....*....
gi 311778175 254 GGPvnSTKFLVYLIYQDAFFNFKFAQACA 282
Cdd:COG1176  233 GGG--KVLMIGNLIYQQFLSALNWPLAAA 259
malF PRK10999
maltose ABC transporter permease MalF;
67-256 4.73e-16

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 78.08  E-value: 4.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  67 FVGFANYINLLTSPD----FLNSLLVTSKYVVVNTMFSIVGGLVLALSV--DNNKYfKKFFKISFTLPISLSSASAAIVW 140
Cdd:PRK10999 264 TIGWKNFTRVFTDEGiqkpFIAIFIWTVVFSLLTVVLTVAVGMVLACLVqwEALKG-KAVYRVLLILPYAVPSFISILIF 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 141 GILFNPTVSIINYVLESFCFSKIEWLTDPKVALYSIVLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTK 220
Cdd:PRK10999 343 KGLFNQSFGEINMMLSALFGIKPAWFSDPTLAKTMILIVNTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGPFQNFFK 422

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 311778175 221 IVLPL----LTPSLFFTLVINvidsFQQFTVVHILTRGGP 256
Cdd:PRK10999 423 ITLPLlikpLTPLMIASFAFN----FNNFVLIQLLTNGGP 458
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 13-245 9.11e-13

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 67.04  E-value: 9.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  13 KVKKRRKRSMKEIWEFVLLvsptfILLTSFVFLPFLKTLYTSFCITD--FNANVKKF---VGFANYINLLTSPDF----L 83
Cdd:COG0395    3 ATARRRRRRLGRILLYLLL-----ILLALLFLFPLYWMVVTSFKPPAeiFSGPPSLLpseFTLENYRAAFTDGPFgrylL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  84 NSLLVTSKYVVVNTMFSIVGGLVLAlsvdnnkyfKKFFKISFTLpislssaSAAIVWGILFNPTVSII-NYVLesfcFSK 162
Cdd:COG0395   78 NSLIVAVVSTVLSLLLSSLAAYALA---------RFRFRGRKLL-------FLLILATLMIPGQVLLIpLYLL----FRQ 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 163 IEWL-TdpkvaLYSIVLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDS 241
Cdd:COG0395  138 LGLLnT-----YWGLILPYLAFGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGA 212


                 ....
gi 311778175 242 FQQF 245
Cdd:COG0395  213 WNDF 216
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 82-275 3.41e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 58.44  E-value: 3.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  82 FLNSLLVTSKYVVVNTMFSIVGGLVLALsvdNNKYFKKFFKISFTLPISLSSASAAIVWGILFNPtvsiinyvlesfcfs 161
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILAR---KRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGV--------------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 162 KIEWLTDPKVALYSIVLINAWQnIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDS 241
Cdd:cd06261   63 LLGWGILPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARA 141

                        170       180       190
                 ....*....|....*....|....*....|....
gi 311778175 242 FQQFTVVHILTrGGPVNSTKFLVYLIYQDAFFNF 275
Cdd:cd06261  142 LGEFALVSFLG-GGEAPGPGTGLLLIFAILFPGD 174
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 163-280 6.54e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 54.61  E-value: 6.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  163 IEWLTDPKVALYSIVLINAWQNIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSF 242
Cdd:pfam00528  42 IAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGAL 121

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 311778175  243 QQFTVVHILTRGGPVNSTKFLVYLIYQDAFFNFKFAQA 280
Cdd:pfam00528 122 GGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAA 159
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
36-269 6.56e-09

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 56.71  E-value: 6.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  36 FILLTSFVFLPFLKTLYTSFcitdfNANVKKFVGFANYINLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLA-LSVDNN 114
Cdd:COG1178  295 LLLVLLGLLLPLLALLLWSL-----TKALDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAyLVRRRR 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 115 KYFKKFFKISFTLPISLSSASAAIVWGILFNPTVSIINYVlesfcfskiewltdpkvALYSIVLINAWQNIPFNFLFLLA 194
Cdd:COG1178  370 GRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPLLLYG-----------------TLAILVLAYVVRFLPFALRSLEA 432

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311778175 195 GLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSFQQFTVVHILTRGGpvnsTKFLVYLIYQ 269
Cdd:COG1178  433 ALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPG----FETLAVLIYQ 503
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 28-231 2.30e-08

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 53.99  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  28 FVLLVSPTFILLTSFVFLPFLKTLYTSFCItdfnanvkkfvGFANYINLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVL 107
Cdd:COG0555    9 FGLTLGLTLLYLSLIVLLPLAALVLKAAGL-----------GWAEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 108 ALS-VDNNKYFKKFFKISFTLPISLSSASAAIVWGILFNPTvSIINYVLESFCFskiewltdpKVAlYS---IVLINAWQ 183
Cdd:COG0555   78 AWVlVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPN-GWLGQLLAPLGI---------KVA-FTplgIVLAQTFV 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 311778175 184 NIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLF 231
Cdd:COG0555  147 SLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALL 194
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 36-255 1.68e-07

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 51.27  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  36 FILLTSFVFLPFLKTLYTSFCITDFNANVKKFVGFANYINLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLALSVDNNK 115
Cdd:COG1177   13 LALVLLFLYLPILVLVLYSFNDSWFLTFPPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAALALARYR 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 116 Y-FKKFFKISFTLPIslssASAAIVWGILFnptvsiinyvleSFCFSKIEWLTdpkvALYSIVLINAWQNIPFNFLFLLA 194
Cdd:COG1177   93 FrGRRLLLALLLLPL----VVPGIVLGVAL------------LLLFSALGLSG----GLWGLILAHVVFTLPFVVLVVLA 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 311778175 195 GLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLF------FTLvinvidSFQQFTVVHILTRGG 255
Cdd:COG1177  153 RLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILagallaFTL------SFDEFVITLFLAGPG 213
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 37-272 8.42e-06

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 46.98  E-value: 8.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175   37 ILLTSFVFLPFLKTLYTSFCITDfnanvKKFVGFANYINLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLALSVD-NNK 115
Cdd:TIGR03262  12 LALLLFLLLPLLALLTKSVYDSD-----GDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTrSRI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  116 YFKKFFKISFTLPI---SLSSASAAIVW----GILfnptvsiinyvlesfcfskIEWLTDPKV-ALYSIVLINAWQNIPF 187
Cdd:TIGR03262  87 PGKGAFRLVALLPLlapSLLPAISLIYLfgnqGLL-------------------KGLLGGFSIyGFWGIVIGEVFYTFPH 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  188 NFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSFQQFTVVHILTRGGPVNSTKFLVYLI 267
Cdd:TIGR03262 148 ALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKVIGGDYNVLATDIYKQVI 227


                  ....*
gi 311778175  268 YQDAF 272
Cdd:TIGR03262 228 GQQNF 232
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 74-238 1.52e-05

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 45.52  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  74 INLLTSPDFLNSLLVTSKYVVVNTMFSIVGGLVLALSVDNNKYFKKFFK--ISFTLPISlssasaAIVWGILFnptvsII 151
Cdd:COG0600   51 VELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDplLVFLRPIP------PLALAPLL-----IL 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 152 nyvlesfcfskieWLTDPKVALYSIVLINAwqnIPFNFLFLLAGLQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLF 231
Cdd:COG0600  120 -------------WFGIGEASKIFVIFLGA---FFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIF 183


                 ....*..
gi 311778175 232 FTLVINV 238
Cdd:COG0600  184 TGLRIAL 190
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 12-245 4.44e-04

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 41.29  E-value: 4.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  12 IKVKKRRKRSMKE-IWEFVLLvsptfILLTSFVFLPFLKTLYTSFCITDFNANVKKF---VGFANYINLLTSPDFL---- 83
Cdd:COG3833    2 SRRKSRKRRRRLKlGLRHLVL-----IILAIIALFPILWVVSASFNPGGSLYSSSLIpenFTLENYKKLFTETPFLrwfl 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175  84 NSLLVTSKYVVVNTMFSIVGGLVLALSvdnNKYFKKFFKISFtLPISLSSASAAIVwGIlfnptvsiinYVLesfcFSKI 163
Cdd:COG3833   77 NSLIVAVVTAIISVFLAALAAYAFSRF---RFKGRKAGLLAL-LLLQMFPAFLALV-AL----------YLL----LSAL 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311778175 164 EwLTDPKVALysiVLINAWQNIPFNFlFLLAG-LQNIPQELYEVAEIDGANFAKKLTKIVLPLLTPSLFFTLVINVIDSF 242
Cdd:COG3833  138 G-LLNTLLGL---ILVYLGGAIPFNT-WLMKGyFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPW 212


                 ...
gi 311778175 243 QQF 245
Cdd:COG3833  213 NDF 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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