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Conserved domains on  [gi|310750790|gb|ADP09188|]
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RadA, partial [Natrinema pallidum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
radA super family cl35256
DNA repair and recombination protein RadA; Validated
 1-161 6.85e-82

DNA repair and recombination protein RadA; Validated


The actual alignment was detected with superfamily member PRK04301:

Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 244.02  E-value: 6.85e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRGLpdeaidatledrdiegsaddedavDELVEDVLEKI 80
Cdd:PRK04301 116 TQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAEAL------------------------GLDPDEVLDNI 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAGEhedsEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:PRK04301 172 HVARAYNSDHQMLLAEKAEELIKE----GENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYNAAVV 247


                 .
gi 310750790 161 V 161
Cdd:PRK04301 248 V 248
 
Name Accession Description Interval E-value
radA PRK04301
DNA repair and recombination protein RadA; Validated
 1-161 6.85e-82

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 244.02  E-value: 6.85e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRGLpdeaidatledrdiegsaddedavDELVEDVLEKI 80
Cdd:PRK04301 116 TQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAEAL------------------------GLDPDEVLDNI 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAGEhedsEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:PRK04301 172 HVARAYNSDHQMLLAEKAEELIKE----GENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYNAAVV 247


                 .
gi 310750790 161 V 161
Cdd:PRK04301 248 V 248
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 1-161 7.52e-72

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 218.46  E-value: 7.52e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790    1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRGlpdeaidatledrdiegsaddeDAVDElvEDVLEKI 80
Cdd:TIGR02236 109 TQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMAEA----------------------RGLDP--DEVLKNI 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   81 HVAKAFNSNHQMLLAEKAKELAGEHEDseyPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:TIGR02236 165 YVARAYNSNHQMLLVEKAEDLIKELNN---PVKLLIVDSLTSHFRAEYVGRGALAERQQKLNKHLHDLLRLADLYNAAVV 241


                  .
gi 310750790  161 V 161
Cdd:TIGR02236 242 V 242
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 1-161 1.22e-70

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 212.61  E-value: 1.22e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRGLpdeaidatledrdiegsaddedavDELVEDVLEKI 80
Cdd:cd19515   33 TQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMAKAL------------------------GLDPDEVLDNI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAGEHEdseyPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:cd19515   89 YVARAYNSNHQMLLVEKAEDLIKEGN----NIKLLIVDSLTSHFRAEYVGRGTLAERQQKLNKHLHDLHRLADLYNIAVL 164


                 .
gi 310750790 161 V 161
Cdd:cd19515  165 V 165
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 1-161 2.17e-39

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 133.58  E-value: 2.17e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790    1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIddmvrglpdEAIdatLEDRDIEGsaddedavdelvEDVLEKI 80
Cdd:pfam08423  51 TQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERL---------VAI---AERYGLDP------------EDVLDNV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   81 HVAKAFNSNHQM-LLAEKAKELagehedSEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAV 159
Cdd:pfam08423 107 AYARAYNSEHQMqLLQQAAAMM------SESRFALLIVDSATALYRTDFSGRGELAERQQHLAKFLRTLQRLADEFGVAV 180


                  ..
gi 310750790  160 IV 161
Cdd:pfam08423 181 VI 182
 
Name Accession Description Interval E-value
radA PRK04301
DNA repair and recombination protein RadA; Validated
 1-161 6.85e-82

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 244.02  E-value: 6.85e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRGLpdeaidatledrdiegsaddedavDELVEDVLEKI 80
Cdd:PRK04301 116 TQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAEAL------------------------GLDPDEVLDNI 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAGEhedsEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:PRK04301 172 HVARAYNSDHQMLLAEKAEELIKE----GENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYNAAVV 247


                 .
gi 310750790 161 V 161
Cdd:PRK04301 248 V 248
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 1-161 7.52e-72

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 218.46  E-value: 7.52e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790    1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRGlpdeaidatledrdiegsaddeDAVDElvEDVLEKI 80
Cdd:TIGR02236 109 TQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMAEA----------------------RGLDP--DEVLKNI 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   81 HVAKAFNSNHQMLLAEKAKELAGEHEDseyPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:TIGR02236 165 YVARAYNSNHQMLLVEKAEDLIKELNN---PVKLLIVDSLTSHFRAEYVGRGALAERQQKLNKHLHDLLRLADLYNAAVV 241


                  .
gi 310750790  161 V 161
Cdd:TIGR02236 242 V 242
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 1-161 1.22e-70

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 212.61  E-value: 1.22e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRGLpdeaidatledrdiegsaddedavDELVEDVLEKI 80
Cdd:cd19515   33 TQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMAKAL------------------------GLDPDEVLDNI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAGEHEdseyPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:cd19515   89 YVARAYNSNHQMLLVEKAEDLIKEGN----NIKLLIVDSLTSHFRAEYVGRGTLAERQQKLNKHLHDLHRLADLYNIAVL 164


                 .
gi 310750790 161 V 161
Cdd:cd19515  165 V 165
Rad51_DMC1_archRadA cd01123
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ...
 1-161 2.90e-42

recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .


Pssm-ID: 410868 [Multi-domain]  Cd Length: 234  Bit Score: 140.36  E-value: 2.90e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVrglpdeaidatlEDRDIEGSaddedavdelveDVLEKI 80
Cdd:cd01123   33 TQLCHTLAVTCQLPIDRGGGEGKAIYIDTEGTFRPERLRAIA------------QRFGLDPD------------DVLDNV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAgehedSEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:cd01123   89 AYARAFNSDHQTQLLDQAAAMM-----VESRFKLLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLADEFGVAVV 163


                 .
gi 310750790 161 V 161
Cdd:cd01123  164 V 164
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 1-161 2.17e-39

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 133.58  E-value: 2.17e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790    1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIddmvrglpdEAIdatLEDRDIEGsaddedavdelvEDVLEKI 80
Cdd:pfam08423  51 TQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERL---------VAI---AERYGLDP------------EDVLDNV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   81 HVAKAFNSNHQM-LLAEKAKELagehedSEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAV 159
Cdd:pfam08423 107 AYARAYNSEHQMqLLQQAAAMM------SESRFALLIVDSATALYRTDFSGRGELAERQQHLAKFLRTLQRLADEFGVAV 180


                  ..
gi 310750790  160 IV 161
Cdd:pfam08423 181 VI 182
DMC1 cd19514
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ...
 1-161 3.77e-38

homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.


Pssm-ID: 410922 [Multi-domain]  Cd Length: 236  Bit Score: 129.78  E-value: 3.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIddmvrglpdeaidatledRDIegsAD----DEDAVdelvedv 76
Cdd:cd19514   33 TQLSHTLCVTAQLPGSMGGGGGKVAYIDTEGTFRPDRI------------------RPI---AErfgvDHDAV------- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  77 LEKIHVAKAFNSNHQM-LLAEKAKELageHEDSEYpvRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLY 155
Cdd:cd19514   85 LDNILYARAYTSEHQMeLLDYVAAKF---HEEAVF--RLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 159


                 ....*.
gi 310750790 156 NAAVIV 161
Cdd:cd19514  160 NVAVFI 165
PTZ00035 PTZ00035
Rad51 protein; Provisional
 1-161 2.90e-36

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 127.81  E-value: 2.90e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIddmvrglpdEAIdatLEDRDIEGsaddedavdelvEDVLEKI 80
Cdd:PTZ00035 132 TQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFRPERI---------VQI---AERFGLDP------------EDVLDNI 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQM-LLAEKAKELAgehedsEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAV 159
Cdd:PTZ00035 188 AYARAYNHEHQMqLLSQAAAKMA------EERFALLIVDSATALFRVDYSGRGELAERQQHLGKFLRALQKLADEFNVAV 261


                 ..
gi 310750790 160 IV 161
Cdd:PTZ00035 262 VI 263
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 1-161 9.67e-35

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 123.35  E-value: 9.67e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790    1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIddmvrglpdeaidatledRDI-EGSADDEDAVdelvedvLEK 79
Cdd:TIGR02238 110 TQLSHTLCVTAQLPREMGGGNGKVAYIDTEGTFRPDRI------------------RAIaERFGVDPDAV-------LDN 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   80 IHVAKAFNSNHQM-LLAEKAKELagehedSEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAA 158
Cdd:TIGR02238 165 ILYARAYTSEHQMeLLDYLAAKF------SEEPFRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSRLNKISEEFNVA 238


                  ...
gi 310750790  159 VIV 161
Cdd:TIGR02238 239 VFV 241
Rad51 cd19513
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ...
 1-161 1.00e-33

RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.


Pssm-ID: 410921 [Multi-domain]  Cd Length: 235  Bit Score: 118.57  E-value: 1.00e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDdmvrglpdeaidATLEDRDIEGsaddedavdelvEDVLEKI 80
Cdd:cd19513   33 TQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLL------------AIAERYGLNG------------EDVLDNV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAGEHEDSeypvrLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:cd19513   89 AYARAYNTDHQMQLLIQASAMMAESRYA-----LLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLADEFGVAVV 163


                 .
gi 310750790 161 V 161
Cdd:cd19513  164 I 164
PLN03187 PLN03187
meiotic recombination protein DMC1 homolog; Provisional
 1-161 2.84e-30

meiotic recombination protein DMC1 homolog; Provisional


Pssm-ID: 215620 [Multi-domain]  Cd Length: 344  Bit Score: 112.18  E-value: 2.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVrglpdeaidatledrdiEGSADDEDAVdelvedvLEKI 80
Cdd:PLN03187 140 TQLAHTLCVTTQLPTEMGGGNGKVAYIDTEGTFRPDRIVPIA-----------------ERFGMDADAV-------LDNI 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQM--LLAEKAKElagehedSEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAA 158
Cdd:PLN03187 196 IYARAYTYEHQYnlLLGLAAKM-------AEEPFRLLIVDSVIALFRVDFTGRGELAERQQKLAQMLSRLTKIAEEFNVA 268


                 ...
gi 310750790 159 VIV 161
Cdd:PLN03187 269 VYM 271
PLN03186 PLN03186
DNA repair protein RAD51 homolog; Provisional
 1-161 6.74e-28

DNA repair protein RAD51 homolog; Provisional


Pssm-ID: 178728 [Multi-domain]  Cd Length: 342  Bit Score: 105.58  E-value: 6.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDmvrglpdeaidatLEDR-DIEGsaddedavdelvEDVLEK 79
Cdd:PLN03186 137 TQLCHTLCVTCQLPLDQGGGEGKAMYIDTEGTFRPQRLIQ-------------IAERfGLNG------------ADVLEN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  80 IHVAKAFNSNHQM-LLAEKAKELAgehedsEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAA 158
Cdd:PLN03186 192 VAYARAYNTDHQSeLLLEAASMMA------ETRFALMIVDSATALYRTEFSGRGELSARQMHLGKFLRSLQRLADEFGVA 265


                 ...
gi 310750790 159 VIV 161
Cdd:PLN03186 266 VVI 268
recomb_RAD51 TIGR02239
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ...
 1-161 8.07e-28

DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).


Pssm-ID: 274048 [Multi-domain]  Cd Length: 316  Bit Score: 105.19  E-value: 8.07e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790    1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIddmvrglpdeaidATLEDR-DIEGsaddedavdelvEDVLEK 79
Cdd:TIGR02239 110 TQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERL-------------LAIAERyGLNP------------EDVLDN 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   80 IHVAKAFNSNHQMLLAEKAKELAGEhedSEYPvrLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAV 159
Cdd:TIGR02239 165 VAYARAYNTDHQLQLLQQAAAMMSE---SRFA--LLIVDSATALYRTDFSGRGELSARQMHLARFLRSLQRLADEFGVAV 239


                  ..
gi 310750790  160 IV 161
Cdd:TIGR02239 240 VI 241
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 1-161 9.95e-17

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 74.25  E-value: 9.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRGLPDEAIdatledrdiegsaddedavDELVEDVLEKI 80
Cdd:cd19491   26 TQLCLQLALTVQLPRELGGLGGGAVYICTESSFPSKRLQQLASSLPKRYH-------------------LEKAKNFLDNI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQM-LLAEKAKELAGEHedseyPVRLLCVDSLTAHFRAEYV-GRGELADRQQKLNKHLHDLDKVGNLYNAA 158
Cdd:cd19491   87 FVEHVADLETLEhCLNYQLPALLERG-----PIRLVVIDSIAALFRSEFDtSRSDLVERAKYLRRLADHLKRLADKYNLA 161


                 ...
gi 310750790 159 VIV 161
Cdd:cd19491  162 VVV 164
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 1-161 1.61e-13

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 64.68  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLpqevggLHGSAIFMDSEDTFRPERIDDMVrglpdEAIDATLEDrdiegsaddedavdelVEDVLEKI 80
Cdd:cd01393   15 TQLALQLAANALL------LGGGVVWIDTEGAFPPSRLVQIL-----EASPSSELE----------------LAEALSRL 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAGEHEDseypVRLLCVDSLTAHFRAEYVGRGE----LADRQQKLNKHLHDLDKVGNLYN 156
Cdd:cd01393   68 LYFRPPDTLAHLLALDSLPESLFPPPN----TSLVVVDSVSALFRKAFPRGGDgdssSSLRARLLSQLARALQKLAAQFN 143


                 ....*
gi 310750790 157 AAVIV 161
Cdd:cd01393  144 LAVVV 148
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 1-161 1.39e-10

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 57.33  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFRPERIDDMVRglpdeaidatledRDIEGSADDEDAVDELVEDVLEKI 80
Cdd:cd19493   25 TQFALTLASSAAMPARKGGLDGGVLYIDTESKFSAERLAEIAE-------------ARFPEAFSGFMEENERAEEMLKRV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAfNSNHQMLlaEKAKELagEHEDSEYPVRLLCVDSLTAHFRAEYVG-RGELADRQQKLNKHLHDLDKVGNLYNAAV 159
Cdd:cd19493   92 AVVRV-TTLAQLL--ERLPNL--EEHILSSGVRLVVIDSIAALVRREFGGsDGEVTERHNALAREASSLKRLAEEFRIAV 166


                 ..
gi 310750790 160 IV 161
Cdd:cd19493  167 LV 168
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 1-161 3.26e-10

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 55.69  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNVQLPQEVGGLHGSAIFMDSEDTFrperiddmvrglpdeaidatledrdiegsaddedavdelvedvleKI 80
Cdd:cd19492   15 TQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF---------------------------------------------NI 49

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  81 HVAKAFNSNHQMLLAEKAKELAGEHEDseypVRLLCVDSLTAHFRAEYvgrGELADRQQKLNKHLHDLDKVGNLYNAAVI 160
Cdd:cd19492   50 HYFRVHDYVELLALINSLPKFLEDHPK----VKLIVVDSIAFPFRHDF---DDLAQRTRLLNGLAQLLHSLARQHNLAVV 122


                 .
gi 310750790 161 V 161
Cdd:cd19492  123 L 123
radB PRK09361
DNA repair and recombination protein RadB; Provisional
 22-161 8.00e-05

DNA repair and recombination protein RadB; Provisional


Pssm-ID: 236482 [Multi-domain]  Cd Length: 225  Bit Score: 41.00  E-value: 8.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790  22 GSAIFMDSEdTFRPERIDDMVRGLPDEaidatledrdiegsaddedavdelvedVLEKIHVAKAFNSNHQMLLAEKAKEL 101
Cdd:PRK09361  52 KKVIYIDTE-GLSPERFKQIAGEDFEE---------------------------LLSNIIIFEPSSFEEQSEAIRKAEKL 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790 102 AGEHedseypVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLDKVGNLYNAAVIV 161
Cdd:PRK09361 104 AKEN------VGLIVLDSATSLYRLELEDEEDNSKLNRELGRQLTHLLKLARKHDLAVVI 157
Rad51D cd19489
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 1-122 2.71e-04

RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410897 [Multi-domain]  Cd Length: 209  Bit Score: 39.54  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310750790   1 SQVTHQMAVNV--QLPQEVgglhgsaIFMDSEDTFRPERIDDMvrglpdeaidatledrdIEGSADDEDAVDElvedVLE 78
Cdd:cd19489   21 TQLCLTAAANVasRSGQNV-------LYIDTKSSFSARRLAQI-----------------LKSRAQDAEEIDK----ALQ 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 310750790  79 KIHVAKAFNSNHQM-LLAEKAKELAGEHEDSEYPVRLLCVDSLTA 122
Cdd:cd19489   73 RIRVVRVFDPYELLdLLEELRNTLSQQQENLYSRLKLVIIDSLSA 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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