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Conserved domains on  [gi|753309274|gb|ADK17615|]
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PTS system fructose subfamily transporter subunit IIA [Lacticaseibacillus paracasei]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10006772)

PTS mannose/fructose/sorbose family sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

CATH:  3.40.50.510
Gene Ontology:  GO:0009401|GO:0016310|GO:0016301|GO:0008643|GO:1902495
PubMed:  11532441|10393270
SCOP:  4000512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 1-101 1.74e-30

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


:

Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 104.84  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274   1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEGQDD---VVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVISFL 77
Cdd:COG2893   19 MILGEQENVEAVDLYPGDDPEDLREKLEEAIAELDSgdgVLILTDLFGGTPSNVAARLLAKHENVEVIAGVNLPMLLEAL 98

                         90       100
                 ....*....|....*....|....*...
gi 753309274  78 NAQML----DMKPDLIGDGKAGIAYIND 101
Cdd:COG2893   99 TYREDlsldELVEKALEAGREGIKSLSE 126
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 1-101 1.74e-30

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 104.84  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274   1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEGQDD---VVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVISFL 77
Cdd:COG2893   19 MILGEQENVEAVDLYPGDDPEDLREKLEEAIAELDSgdgVLILTDLFGGTPSNVAARLLAKHENVEVIAGVNLPMLLEAL 98

                         90       100
                 ....*....|....*....|....*...
gi 753309274  78 NAQML----DMKPDLIGDGKAGIAYIND 101
Cdd:COG2893   99 TYREDlsldELVEKALEAGREGIKSLSE 126
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 1-87 1.65e-24

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 89.59  E-value: 1.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274   1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEG---QDDVVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVISFL 77
Cdd:cd00006   21 MILGEQENVEAIDFPPGESPDDLLEKIKAALAEldsGEGVLILTDLFGGSPNNAAARLSMEHPPVEVIAGVNLPMLLEAA 100

                         90
                 ....*....|
gi 753309274  78 NAQMLDMKPD 87
Cdd:cd00006  101 RARELGLSLD 110
EIIA-man pfam03610
PTS system fructose IIA component;
1-88 5.33e-16

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 67.66  E-value: 5.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274    1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVE---GQDDVVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVI-SF 76
Cdd:pfam03610  20 MMAGEQENVIAVGGTPGESIGTSFEKIVEAIEnldSGDGVLVLVDLGGATPNNEAALELLEKERMEVITGVNLPMVEgAY 99

                          90
                  ....*....|..
gi 753309274   77 LNAQMLDMKPDL 88
Cdd:pfam03610 100 AARVSASLGELV 111
EIIA-man TIGR00824
PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters ...
 1-80 2.75e-13

PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129904  Cd Length: 116  Bit Score: 60.55  E-value: 2.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274    1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEGQD---DVVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVISFL 77
Cdd:TIGR00824  22 MIFGEQNNVGAVPFVPGENAETLQEKYNAALADLDteeEVLFLVDIFGGSPYNAAARIIVDKPHMDVIAGVNLPLLLETL 101


                  ...
gi 753309274   78 NAQ 80
Cdd:TIGR00824 102 MAR 104
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 1-75 2.70e-09

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 52.30  E-value: 2.70e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 753309274   1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEGQDD---VVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVIS 75
Cdd:PRK15088  23 MLLGEQENVAWIDFVPGENAETLIEKYNAQLAKLDTskgVLFLVDTWGGSPFNAASRIVVDKENYEVITGVNIPMLVE 100
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 1-101 1.74e-30

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 104.84  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274   1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEGQDD---VVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVISFL 77
Cdd:COG2893   19 MILGEQENVEAVDLYPGDDPEDLREKLEEAIAELDSgdgVLILTDLFGGTPSNVAARLLAKHENVEVIAGVNLPMLLEAL 98

                         90       100
                 ....*....|....*....|....*...
gi 753309274  78 NAQML----DMKPDLIGDGKAGIAYIND 101
Cdd:COG2893   99 TYREDlsldELVEKALEAGREGIKSLSE 126
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 1-87 1.65e-24

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 89.59  E-value: 1.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274   1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEG---QDDVVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVISFL 77
Cdd:cd00006   21 MILGEQENVEAIDFPPGESPDDLLEKIKAALAEldsGEGVLILTDLFGGSPNNAAARLSMEHPPVEVIAGVNLPMLLEAA 100

                         90
                 ....*....|
gi 753309274  78 NAQMLDMKPD 87
Cdd:cd00006  101 RARELGLSLD 110
EIIA-man pfam03610
PTS system fructose IIA component;
1-88 5.33e-16

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 67.66  E-value: 5.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274    1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVE---GQDDVVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVI-SF 76
Cdd:pfam03610  20 MMAGEQENVIAVGGTPGESIGTSFEKIVEAIEnldSGDGVLVLVDLGGATPNNEAALELLEKERMEVITGVNLPMVEgAY 99

                          90
                  ....*....|..
gi 753309274   77 LNAQMLDMKPDL 88
Cdd:pfam03610 100 AARVSASLGELV 111
EIIA-man TIGR00824
PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters ...
 1-80 2.75e-13

PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129904  Cd Length: 116  Bit Score: 60.55  E-value: 2.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753309274    1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEGQD---DVVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVISFL 77
Cdd:TIGR00824  22 MIFGEQNNVGAVPFVPGENAETLQEKYNAALADLDteeEVLFLVDIFGGSPYNAAARIIVDKPHMDVIAGVNLPLLLETL 101


                  ...
gi 753309274   78 NAQ 80
Cdd:TIGR00824 102 MAR 104
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 1-75 2.70e-09

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 52.30  E-value: 2.70e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 753309274   1 MIMGPQDDITTVALLPNEGPEDFQAKFKAAVEGQDD---VVVLADLKGGTPNNVAARVLAEGGKFDLYSGMNLPMVIS 75
Cdd:PRK15088  23 MLLGEQENVAWIDFVPGENAETLIEKYNAQLAKLDTskgVLFLVDTWGGSPFNAASRIVVDKENYEVITGVNIPMLVE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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