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Conserved domains on  [gi|298236840|gb|ADI67972|]
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methyltransferase domain protein [Mobiluncus curtisii ATCC 43063]

Protein Classification

tRNA (adenine-N1)-methyltransferase( domain architecture ID 11457537)

tRNA (adenine-N1)-methyltransferase, such as tRNA (adenine(58)-N(1))-methyltransferase, which is a class I SAM-dependent methyltransferase that catalyzes the methylation of N(1)-adenine at position 58 (m1A58) in tRNA using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 25-281 8.34e-137

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 389.13  E-value: 8.34e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840  25 SGEWVQLTDEKGRVHTTLLRENGYFQCHQGTLRHQEIIGKPEGTIFPSERGeHRFTALRPLLVDYHLSMPRGAQILYPKD 104
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKG-KEFLVLRPTLYDYVLSMKRGTQIIYPKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 105 AAQIVMEGDIFPGANVVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEVARCNVEMWfcGDVSNWELRLADlsagLR 184
Cdd:COG2519   80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERF--GLPDNVELKLGD----IR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 185 DGVADKSVDRVVLDMLKPWEHLEQVHRVLVPGGVLTCYLTTITQLARMVQDLRNFgGFTSLRSWESLVRPWHVDGLAVRP 264
Cdd:COG2519  154 EGIDEGDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRES-GFTDIEAVETLLREWKVEGLAVRP 232

                        250
                 ....*....|....*..
gi 298236840 265 DHRMIAHTGFIFTARRL 281
Cdd:COG2519  233 EHRMVGHTGFLVFARKL 249
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 25-281 8.34e-137

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 389.13  E-value: 8.34e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840  25 SGEWVQLTDEKGRVHTTLLRENGYFQCHQGTLRHQEIIGKPEGTIFPSERGeHRFTALRPLLVDYHLSMPRGAQILYPKD 104
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKG-KEFLVLRPTLYDYVLSMKRGTQIIYPKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 105 AAQIVMEGDIFPGANVVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEVARCNVEMWfcGDVSNWELRLADlsagLR 184
Cdd:COG2519   80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERF--GLPDNVELKLGD----IR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 185 DGVADKSVDRVVLDMLKPWEHLEQVHRVLVPGGVLTCYLTTITQLARMVQDLRNFgGFTSLRSWESLVRPWHVDGLAVRP 264
Cdd:COG2519  154 EGIDEGDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRES-GFTDIEAVETLLREWKVEGLAVRP 232

                        250
                 ....*....|....*..
gi 298236840 265 DHRMIAHTGFIFTARRL 281
Cdd:COG2519  233 EHRMVGHTGFLVFARKL 249
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 20-69 4.55e-23

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 90.25  E-value: 4.55e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 298236840   20 RGPFRSGEWVQLTDEKGRVHTTLLRENGYFQCHQGTLRHQEIIGKPEGTI 69
Cdd:pfam14801   1 RGPFRAGDRVQLTDPKGRKHTITLEPGGEFHTHRGAIRHDDLIGRPEGSV 50
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 119-219 3.96e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 3.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 119 NVVEAGVGSGAMTMSLLGAVGssGHVTSFELRPDFAEVARcnvEMWFCGDVSNWELRLADLSAGLRDgvADKSVDRVVLD 198
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELAR---KAAAALLADNVEVLKGDAEELPPE--ADESFDVIISD 73

                         90       100
                 ....*....|....*....|....*..
gi 298236840 199 ------MLKPWEHLEQVHRVLVPGGVL 219
Cdd:cd02440   74 pplhhlVEDLARFLEEARRLLKPGGVL 100
PRK08317 PRK08317
hypothetical protein; Provisional
 113-217 1.01e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 46.08  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 113 DIFPGANVVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEVARcnveMWFCGDVSNWELRLADLsAGLrdGVADKSV 192
Cdd:PRK08317  16 AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAK----ERAAGLGPNVEFVRGDA-DGL--PFPDGSF 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 298236840 193 DRVVLDmlKPWEHLEQ-------VHRVLVPGG 217
Cdd:PRK08317  89 DAVRSD--RVLQHLEDparalaeIARVLRPGG 118
rADc smart00650
Ribosomal RNA adenine dimethylases;
105-158 4.25e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 40.57  E-value: 4.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 298236840   105 AAQIVMEGDIFPGANVVEAGVGSGAMTMSLLGAvgsSGHVTSFELRPDFAEVAR 158
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLER---AKRVTAIEIDPRLAPRLR 52
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 25-281 8.34e-137

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 389.13  E-value: 8.34e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840  25 SGEWVQLTDEKGRVHTTLLRENGYFQCHQGTLRHQEIIGKPEGTIFPSERGeHRFTALRPLLVDYHLSMPRGAQILYPKD 104
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKG-KEFLVLRPTLYDYVLSMKRGTQIIYPKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 105 AAQIVMEGDIFPGANVVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEVARCNVEMWfcGDVSNWELRLADlsagLR 184
Cdd:COG2519   80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERF--GLPDNVELKLGD----IR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 185 DGVADKSVDRVVLDMLKPWEHLEQVHRVLVPGGVLTCYLTTITQLARMVQDLRNFgGFTSLRSWESLVRPWHVDGLAVRP 264
Cdd:COG2519  154 EGIDEGDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRES-GFTDIEAVETLLREWKVEGLAVRP 232

                        250
                 ....*....|....*..
gi 298236840 265 DHRMIAHTGFIFTARRL 281
Cdd:COG2519  233 EHRMVGHTGFLVFARKL 249
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 20-69 4.55e-23

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 90.25  E-value: 4.55e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 298236840   20 RGPFRSGEWVQLTDEKGRVHTTLLRENGYFQCHQGTLRHQEIIGKPEGTI 69
Cdd:pfam14801   1 RGPFRAGDRVQLTDPKGRKHTITLEPGGEFHTHRGAIRHDDLIGRPEGSV 50
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 91-257 1.81e-20

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 89.09  E-value: 1.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840   91 LSMPRGAQILYPKDAAQIVMEGDIFPGANVVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEVARcnVEMWFCGDVS 170
Cdd:pfam08704  15 LNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKAR--EEFREHGIDQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840  171 NWELRLADL-SAGLRDGVADKsVDRVVLDMLKPWEHLEQVHRVL-VPGGVLTCYLTTITQLARMVQDLRNFgGFTSLRSW 248
Cdd:pfam08704  93 LVTVTHRDVcKEGFLTEVSGK-ADAVFLDLPSPWEAVPHAWKALkVEGGRFCSFSPCIEQVQRTCQALAEL-GFTEISTL 170


                  ....*....
gi 298236840  249 ESLVRPWHV 257
Cdd:pfam08704 171 EVLLRVYDV 179
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 119-219 3.96e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 3.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 119 NVVEAGVGSGAMTMSLLGAVGssGHVTSFELRPDFAEVARcnvEMWFCGDVSNWELRLADLSAGLRDgvADKSVDRVVLD 198
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELAR---KAAAALLADNVEVLKGDAEELPPE--ADESFDVIISD 73

                         90       100
                 ....*....|....*....|....*..
gi 298236840 199 ------MLKPWEHLEQVHRVLVPGGVL 219
Cdd:cd02440   74 pplhhlVEDLARFLEEARRLLKPGGVL 100
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 93-219 1.95e-07

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 50.18  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840  93 MPRGAQILYpkdaaQIVMegdIFPGANVVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEVARCNVEMWFCGDvsNW 172
Cdd:COG4122    1 MPEQGRLLY-----LLAR---LLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLAD--RI 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 298236840 173 ELRLADLSAGLRDgVADKSVDRVVLDMLKPW--EHLEQVHRVLVPGGVL 219
Cdd:COG4122   71 RLILGDALEVLPR-LADGPFDLVFIDADKSNypDYLELALPLLRPGGLI 118
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 116-240 3.37e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.22  E-value: 3.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 116 PGANVVEAGVGSGAMTMSLLGAvgsSGHVTSFELRPDFAEVAR-------CNVEmWFCGDVSNWELrladlsaglrdgvA 188
Cdd:COG2226   22 PGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELAReraaeagLNVE-FVVGDAEDLPF-------------P 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 298236840 189 DKSVDRV----VLDMLKPWEH-LEQVHRVLVPGGVLTCYLTTITQLARMVQDLRNFG 240
Cdd:COG2226   85 DGSFDLVissfVLHHLPDPERaLAEIARVLKPGGRLVVVDFSPPDLAELEELLAEAG 141
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 120-217 7.05e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.79  E-value: 7.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840  120 VVEAGVGSGAMTMSLLGAVGssGHVTSFELRPDFAEVAR-------CNVEmWFCGDVSNWELrladlsaglrdgvADKSV 192
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERAReraaeagLNVE-FVQGDAEDLPF-------------PDGSF 64

                          90       100       110
                  ....*....|....*....|....*....|..
gi 298236840  193 DRV----VLDMLKPWEH---LEQVHRVLVPGG 217
Cdd:pfam13649  65 DLVvssgVLHHLPDPDLeaaLREIARVLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 116-219 8.10e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 45.31  E-value: 8.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 116 PGANVVEAGVGSGAMTMSLLGAVGSsgHVTSFELRPDFAEVARCNVEMWFCGDvsNWELRLADLsaglRDGVADKSVDRV 195
Cdd:COG2230   51 PGMRVLDIGCGWGGLALYLARRYGV--RVTGVTLSPEQLEYARERAAEAGLAD--RVEVRLADY----RDLPADGQFDAI 122

                         90       100       110
                 ....*....|....*....|....*....|....
gi 298236840 196 V-LDMLkpwEH---------LEQVHRVLVPGGVL 219
Cdd:COG2230  123 VsIGMF---EHvgpenypayFAKVARLLKPGGRL 153
PRK08317 PRK08317
hypothetical protein; Provisional
 113-217 1.01e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 46.08  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 113 DIFPGANVVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEVARcnveMWFCGDVSNWELRLADLsAGLrdGVADKSV 192
Cdd:PRK08317  16 AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAK----ERAAGLGPNVEFVRGDA-DGL--PFPDGSF 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 298236840 193 DRVVLDmlKPWEHLEQ-------VHRVLVPGG 217
Cdd:PRK08317  89 DAVRSD--RVLQHLEDparalaeIARVLRPGG 118
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
105-198 3.61e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 44.12  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 105 AAQIV----MEGDIfPGANVVEAGVGSG--AMTMSLLGAvgssGHVTSFELRPDFAEVARCNVEM------WFCGDVSNW 172
Cdd:COG2263   31 AAELLhlayLRGDI-EGKTVLDLGCGTGmlAIGAALLGA----KKVVGVDIDPEALEIARENAERlgvrvdFIRADVTRI 105

                         90       100       110
                 ....*....|....*....|....*....|....
gi 298236840 173 ELrladlsAGLRD--------GVADKSVDRVVLD 198
Cdd:COG2263  106 PL------GGSVDtvvmnppfGAQRRHADRPFLE 133
arsM PRK11873
arsenite methyltransferase;
116-238 9.98e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 43.40  E-value: 9.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 116 PGANVVEagVGSGAMTMSLLGA--VGSSGHVTSFELRPDFAEVARCNVEMwfcGDVSNWELRLADLSAglrDGVADKSVD 193
Cdd:PRK11873  77 PGETVLD--LGSGGGFDCFLAArrVGPTGKVIGVDMTPEMLAKARANARK---AGYTNVEFRLGEIEA---LPVADNSVD 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 298236840 194 RVV------LDMLKPwEHLEQVHRVLVPGGVLtcYLTTITQLARMVQDLRN 238
Cdd:PRK11873 149 VIIsncvinLSPDKE-RVFKEAFRVLKPGGRF--AISDVVLRGELPEEIRN 196
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 114-241 1.54e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 41.63  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840  114 IFPGANVVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEVARCNVEmwfCGDVSNWELRLAD---LSAGLRDGVADK 190
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQ---KLGFDNVEFEQGDieeLPELLEDDKFDV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 298236840  191 SVDRVVLDMLK-PWEHLEQVHRVLVPGGVLTC-YLTTITQLARMVQDLRNFGG 241
Cdd:pfam13847  78 VISNCVLNHIPdPDKVLQEILRVLKPGGRLIIsDPDSLAELPAHVKEDSTYYA 130
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 116-290 3.16e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 41.44  E-value: 3.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 116 PGANVVEAGVGSGAMTMSLLGAVGssGHVTSFELRPDFAEVARCNVEMWFCGDVsnwELRLADLSAglRDGVADKSVDRV 195
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAKAGLGNV---EFLVADLAE--LDPLPAESFDLV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 196 VLDMLkpWEH---------LEQVHRVLVPGGVLtcyLTTITQLARMVQDLRNFGGFTSLRsWESLVRPwhvDGLAVRPDH 266
Cdd:COG0500   99 VAFGV--LHHlppeerealLRELARALKPGGVL---LLSASDAAAALSLARLLLLATASL-LELLLLL---RLLALELYL 169

                        170       180
                 ....*....|....*....|....
gi 298236840 267 RMIAHTGFIFTARRLADGETSIRH 290
Cdd:COG0500  170 RALLAAAATEDLRSDALLESANAL 193
rADc smart00650
Ribosomal RNA adenine dimethylases;
105-158 4.25e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 40.57  E-value: 4.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 298236840   105 AAQIVMEGDIFPGANVVEAGVGSGAMTMSLLGAvgsSGHVTSFELRPDFAEVAR 158
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLER---AKRVTAIEIDPRLAPRLR 52
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 121-219 5.38e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.80  E-value: 5.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840  121 VEAGVGSGAMTMSLLGAVGssgHVTSFELRPDFAEVARCNVEmwfcgdVSNWELRLADLSA-GLRDGVADKSVDRVVLDM 199
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA---RVTGVDISPEMLELAREKAP------REGLTFVVGDAEDlPFPDNSFDLVLSSEVLHH 71

                          90       100
                  ....*....|....*....|.
gi 298236840  200 LK-PWEHLEQVHRVLVPGGVL 219
Cdd:pfam08241  72 VEdPERALREIARVLKPGGIL 92
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
120-248 1.01e-03

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 39.81  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298236840 120 VVEAGVGSGAMTMSLLGAVGSSGHVTSFELRPDFAEV-----ARCNVemwFCGDVsnwelrlADLSAGLRDGVADKsVDR 194
Cdd:COG3963   49 VVELGPGTGVFTRAILARGVPDARLLAVEINPEFAEHlrrrfPRVTV---VNGDA-------EDLAELLAEHGIGK-VDA 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 298236840 195 VV--LdmlkPWEH---------LEQVHRVLVPGGVLT--CYLTTITQLARMVQdlRNFGGFTSLRSW 248
Cdd:COG3963  118 VVsgL----PLLSfppelrraiLDAAFRVLAPGGVFVqfTYSPRSPVPRKLLR--RGFEAVRSGFVW 178
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
102-174 1.73e-03

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 39.66  E-value: 1.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 298236840  102 PKDAAQIVMEGDIFPGANVVEAGVGSGAMTMSLLgavGSSGHVTSFELRPDFAEVARCNVE-----MWFCGDVSNWEL 174
Cdd:pfam00398  16 PKVINEIVDKANLRESDTVLEIGPGKGALTVILA---KRAKQVVAIEIDPRLAKLLQKKLSldenlTVIHQDFLKFEF 90
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 105-158 6.01e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 37.80  E-value: 6.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 298236840 105 AAQIVMEGDIFPGANVVEAGVGSGAMTMSLLGAVgssGHVTSFELRPDFAEVAR 158
Cdd:COG0030   26 IRRIVDAAGITPGDTVLEIGPGLGALTRALLERA---ARVTAVEIDRRLAAILR 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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