|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
2-974 |
0e+00 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 1939.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 2 TKTLVIAEKPSVAQDIVRALTPVAGKFEKHDDYFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPRFDLKP 81
Cdd:PRK14724 1 TKTLVIAEKPSVAQDIVRALTPVAGKFEKHDEHFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 82 VDKTKTRLNAVVKQAKRKDVTELINACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNNLRSDAQ 161
Cdd:PRK14724 81 VDKTKTRLNAVVKLAKRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFDNLRSDAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 162 MQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAGQ 241
Cdd:PRK14724 161 MQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 242 YLGKWFNPQWKK-SDDAEAKADRLWNKADAEAIAAAVQGKPAQVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTL 320
Cdd:PRK14724 241 YLGKWFDPQWKKaSDDPEARADRVWSEREARAIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 321 ALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFDMLATSGMRHLAPFAQQAINDNYIRPTKRVFDNSKVSDHFAIIPT 400
Cdd:PRK14724 321 ALAQSLYERHKALTYPRTDSRALPEDYLPVAKQTFEMLATSGMRHLAPFAQQALDGNYVRPSKRIFDNSKVSDHFAIIPT 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 401 TQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKEGDKGQ 480
Cdd:PRK14724 401 TQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKDGDKGQ 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 481 PLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLR 560
Cdd:PRK14724 481 PLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLR 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 561 EGRELIPTAKAFQLMTLLRGLEVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYA 640
Cdd:PRK14724 561 EGRELIPTAKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTEKLVKKAKEYDRDTIPGDYA 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 641 TLSTPCPNCGGVVKENYRRYACTGANGASEGCGFSFTKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFVAEVAIV 720
Cdd:PRK14724 641 TLSTPCPNCGGVVKENYRRYACTGANGAGEGCGFSFTKSPAGRTFETAEAEQLLRDRRIGPLEGFRSKAGWPFTAEVVIK 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 721 RDEENSNFKLEFDFGDDKDSEDTGEIVDFAHQQSLGPCPKCGSPVFEHGANYVCSKAVPTLAQTTPSCDFKSGQIILQQP 800
Cdd:PRK14724 721 RDEEAKNYKLEFDFGDDKNAEDTGEIVDFAGQESLGPCPKCGAPVFEHGSNYVCEKSVPTLAQPTPSCTFKSGQVILQQP 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 801 IEREQMSKLLQTGKTDLLEKFVSNRTRRNFKAFLVWDGAAGKVNFEFEQREGKYPAR-----KTAGAAAAKTTTAAAKKT 875
Cdd:PRK14724 801 IEREQMQKLLATGKTDLLDKFVSMRTRRAFKAFLAWDKEAGKVNFEFEPRESKFPPRktaaaKAGAASAAFGGTVAVKAA 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 876 GTAAKKTAAKTATKTAAVKKPRT--------VSATLKPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINA 947
Cdd:PRK14724 881 KPAKKAAAKKVAAKTAAAKTPRKaakkkaapPAAGLKPSAALAAVIGAEPVARPEVIKKLWDYIKANNLQDPADKRAINA 960
|
970 980
....*....|....*....|....*..
gi 262211437 948 DAKLKPVFGKEQISMFELAGIVGKHVS 974
Cdd:PRK14724 961 DAKLRPVFGKDQVTMFELAGIVGKHLS 987
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
1-856 |
0e+00 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 1555.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 1 MTKTLVIAEKPSVAQDIVRALtpvaGKFEKHDDYFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPRFDLK 80
Cdd:PRK08173 1 MSKALIIAEKPSVANDIARAL----GGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 81 PVDKTKTRLNAVVKQAKRKDVTELINACDAGREGELIFRLIEQYAGGAKgglgkPVKRLWLQSMTPQAIRDGFNNLRSDA 160
Cdd:PRK08173 77 PIAKTESRLKVLTKLIKRKDVTRLINACDAGREGELIFRLIAQHAKAKK-----PVKRLWLQSMTPQAIRDGFANLRSDE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 161 QMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAG 240
Cdd:PRK08173 152 DMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVAAAG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 241 QYLGKWFNPQWKKSD-DAEAKADRLWNKADAEAIAAAVQGKPAQVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTT 319
Cdd:PRK08173 232 FYEGRWFDPKFKKDEfDPEKRASRLWSEAAAEAIVAACRGKPGTVTEESKPSTQLSPLLFDLTSLQREANGRFGFSAKNT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 320 LALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFDMLAtsGMRHLAPFAQQAINDNYIRPTKRVFDNSKVSDHFAIIP 399
Cdd:PRK08173 312 LGLAQALYEKHKVLTYPRTDSRALPEDYLGTVKQTLEMLK--ESNNYLPHAKQILDKGWVKPNKRIFDNSKISDHFAIIP 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 400 TTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAanevedakeGDKG 479
Cdd:PRK08173 390 TLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLVNPGWLAVYGKEA---------QGAD 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 480 QPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYML 559
Cdd:PRK08173 461 ANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAEKGLGTPATRAAIIEGLLGEKYLV 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 560 REGRELIPTAKAFQLMTLLRGLEVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDY 639
Cdd:PRK08173 541 REGRELIPTAKAFQLMTLLRGLGVEELTSPELTGEWEYKLSQIERGKLSRDAFMQEIAQMTQQIVKRAKEYDSDTIPGDY 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 640 ATLSTPCPNCGGVVKENYRRYACTgangaseGCGFSFTKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFVAEVAI 719
Cdd:PRK08173 621 ATLQTPCPNCGGVVKENYRRFACT-------KCDFSISKIPGGRQFEIAEVEELLRKKEIGPLSGFRSKMGRPFSAILKL 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 720 VrdEENSNFKLEFDFGDDKDSEDtGEIVDFAHQQSLGPCPKCGSPVFEHGANYVCSKAVPtlaqTTPSCDFKSGQIILQQ 799
Cdd:PRK08173 694 S--DETKNYKLEFDFGQDQGGED-GEPVDFSAQEPVGACPKCGGRVFEHGMSYVCEKSVG----PPKTCDFRSGKVILQQ 766
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*..
gi 262211437 800 PIEREQMSKLLQTGKTDLLEKFVSNRTRRNFKAFLVwDGAAGKVNFEFEQREGKYPA 856
Cdd:PRK08173 767 EISREQMAKLLADGKTDLLPGFKSSRTGRNFKAYLV-KQPDGKIGFEFEPREPKAAA 822
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
3-684 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 673.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 3 KTLVIAEKPSVAQDIVRALTPvagkFEKHDDYFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPRFDLKPV 82
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLKP----HKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDERYKRWRLEDLPIIPEKWKLVVK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 83 DKTKTRLNAVVKQAKrkDVTELINACDAGREGELIFRLIEQYAGGAKgglgkPVKRLWLQSMTPQAIRDGFNNLRSDAQM 162
Cdd:PRK07726 77 KKTAKQFNVVKKLLK--QATEIVIATDADREGELIAREILDYCGVRK-----PIKRLWISSLTDKAIKRAFANLKPGKET 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 163 QGLASAARSRSEADWLVGINGTRAMT--AFNSRDGGFFltTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAG 240
Cdd:PRK07726 150 IPLYYSALARSRADWLVGINMTRAYTllGRKAGYNGVL--SVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTPGER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 241 qylgkwFNPQWKKSDDAEAKADRLWNKADAEAIAAAVQGKPAQVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTT 319
Cdd:PRK07726 228 ------FTAKWQPSEPYQDEEGRLLDRPLAEQVVARIQGQPAKVTEvETKRKKEYAPLLYDLSELQIDANKRFGLSAKET 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 320 LALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFDMLATSGmrhlaPFAQQAIN--DNYIRptKRVFDNSKVSDHFAI 397
Cdd:PRK07726 302 LDIAQSLYETHKLITYPRTDSRYLPEDMVATLPEVLNAISKVD-----PYLLLAPPvlDPSIR--SRAWNDKKVTAHHAI 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 398 IPTTQAP--SGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAANEvedake 475
Cdd:PRK07726 375 IPTEQPPnlSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDE------ 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 476 gDKGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEK-GLGTPATRAAIIEGLLT 554
Cdd:PRK07726 449 -EKEQPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETdGLGTEATRAGIIEKLFK 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 555 EKYMLREGRELIPTAKAFQLMTLLRglevEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDR-- 632
Cdd:PRK07726 528 RGYLEKKGKYIHATDKGKQLIDALP----EELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEky 603
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*
gi 262211437 633 --DTIPGdyatlsTPCPNCGGVVKE-NYRRYACTGANGASEGCGFSFTKSPAGRT 684
Cdd:PRK07726 604 kfDNLTG------PKCPDCGKPMLKvKGKNGKMLVCQDRECGKRKNVSKKTNARC 652
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
3-625 |
0e+00 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 624.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 3 KTLVIAEKPSVAQDIVRALtpvagkfekhddyfeSDSYVVTSAVGHLVEIQAPE-EFDVKRGkwsfanlpVIPprfDLKP 81
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYL---------------GKDYVVTASVGHLRDLPKPElDVDVEND--------FEP---KYEV 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 82 VDKTKTRLNAVVKQAKRKDvtELINACDAGREGELIFRLIEQYAGGAKgglgkPVKRLWLQSMTPQAIRDGFNNLRSdaQ 161
Cdd:COG0550 55 IPGKKKQVKELKKLAKKAD--EVILATDPDREGEAIAWHLLELLGDKK-----PVKRVVFNEITKKAIKEAFKNPRD--I 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 162 MQGLASAARSRSEADWLVGINGTRAMTAFNSRdggffLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAGQ 241
Cdd:COG0550 126 DMNLVDAQQARRILDRLVGYNLSPLLWKKVKR-----GLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGE 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 242 YLGKWFNPQWKKSDDaEAKADRLwnkadaeaiAAAVQGKPAQVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTTL 320
Cdd:COG0550 201 FTAKLVKIDGKKILD-EEEAEAI---------LAALKGKTFTVTSvEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTM 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 321 ALAQSLYERhKALTYPRTDSRALPEDYLPVARQTFDMLAtsgmrhlapfaqqaiNDNYIRPTKRVFDNSK--VSDHFAII 398
Cdd:COG0550 271 SIAQRLYEV-GLITYMRTDSVRLSEDAVAAAREYIEALY---------------GKEYLPEKPRVYKTSKnaQEAHEAIR 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 399 PTTQA--PSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEaanevEDAKEG 476
Cdd:COG0550 335 PTGVTrtPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEG-----KDDEEE 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 477 DKGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEK 556
Cdd:COG0550 410 EEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAME----------------ELGIGRPSTYASIIETLQDRG 473
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262211437 557 YMLREGRELIPTAKAFQLMTLLRGLeVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVK 625
Cdd:COG0550 474 YVEREGKRLVPTELGFIVIDLLEEH-FPDLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
3-672 |
5.62e-178 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 532.11 E-value: 5.62e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 3 KTLVIAEKPSVAQDIVRALtpvaGKFEKHDDYFE-SDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPRFDLKP 81
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVL----AKKKKGNGYLEiGVGGFVTWAVGHLVELAEPEEYDEKYKNWRTYDLPLEPEDWQLVV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 82 VDKTKTRLNAVVKQAKRKDVTELINACDAGREGELIFRLIEQYAGGAKGGlgkPVKRLWLQSMTPQAIRDGFNNLRSDAQ 161
Cdd:TIGR01056 77 SDKTKKQFNVIKRILKENKVDEVVIATDPDREGELIAREILDYLKVTDKV---TIKRLWISSLVDSSIRKAFKNLRPKSE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 162 MQGLASAARSRSEADWLVGINGTRAMTAFnSRDGGF-FLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAG 240
Cdd:TIGR01056 154 TEGLYKSGVARARADWLVGINLTRAFTKL-GREAGNdGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 241 QYLGKWFNPQwkksDDAEakadRLWNKADAEAIAAAVQGKPAQVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTT 319
Cdd:TIGR01056 233 EFTTEWQPYK----DEEE----RELHEFLAENVVTDLTQKPALVTDiEKERKKTSAPLFYDLSALQEDANKRFGISAKRT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 320 LALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFDMLATSgmrhlaPFAQQAINDNYIRPTKRVFDNSKVSDHFAIIP 399
Cdd:TIGR01056 305 LDIAQKLYETHKLITYPRTDSRYLPEDEKEMLLEVLDALKVI------TPALLPIKKRDELTNNRLWNDKKIEDHHAIIP 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 400 T--TQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAanevEDakEGD 477
Cdd:TIGR01056 379 TgnDFNLSDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQE----ED--EET 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 478 KGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQE-KGLGTPATRAAIIEGLLTEK 556
Cdd:TIGR01056 453 EDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKEtKGLGTEATRADIIENLFKRG 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 557 YMLREGRELIPTAKAFQLMTLLRGLeveeLCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKE----YDR 632
Cdd:TIGR01056 533 FIQKKKNKIYITKNGKLLCLLLPEL----LTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEKKnpetIQK 608
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 262211437 633 DTIPGDYATLSTPCPNC-GGVVKENYRRYACTG-ANGASEGC 672
Cdd:TIGR01056 609 VAKEPVSCGGIAKCPAKdNGRLIDCKKFPECTEyGNGCEFTI 650
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
160-614 |
4.36e-128 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 393.53 E-value: 4.36e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 160 AQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFfltTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQA 239
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKGNKLL---SAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 240 GQYlgkwfnpqwkksDDAEAKADRLWNKADAEAIAAAVQGKPAQVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKT 318
Cdd:pfam01131 78 GVF------------ANAKWKRGRIFDKEEAEAILEKLKKGTAVVTSvESKEKKKPPPLPFNTTTLQKEASRKLGFSAKK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 319 TLALAQSLYERHKALTYPRTDSRALPED-YLPVARQTFdmlaTSGMRHLAPFAQQAINDNyirPTKRVFDNSKVSDHFAI 397
Cdd:pfam01131 146 TMSIAQKLYEKHGLITYPRTDSTYLSDDaTLKAILEYL----TKNYGKYLPYAPRLLKKT---KGKLTVGNAKVTAHEAI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 398 IPTTQAP--SGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKE 475
Cdd:pfam01131 219 RPTGDIPvlPELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEELPE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 476 GDKGQPLVAVQpgeqprthhADVKGLKTKPPARYSEATLLGAMESAgkqidddelreamqekGLGTPATRAAIIEGLLTE 555
Cdd:pfam01131 299 LKEGEELKVTQ---------VEVEEKKTKPPPRYTEASLIKAMEKA----------------GIGTPATRATIIETLLER 353
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 262211437 556 KYMLREGRELIPTAKAFQLMTLLRGLevEELCRADLTGEWEFKLSQMEKGQLSREAFMQ 614
Cdd:pfam01131 354 GYVERKKKSLVPTELGKALVEALEKF--PDLVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
164-624 |
2.52e-106 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 335.34 E-value: 2.52e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 164 GLASAARSRSEADWLVGINGTRAMTAFNSRDGGFfltTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVhgtfdaqagqyl 243
Cdd:cd00186 2 NLVNAQLARRILDRLVGFNLSRLLTKKLRRKGVL---SAGRVQSPTLGLIVEREREIKAFVPEDYWEI------------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 244 gkwfnpqwkksddaeakadrlwnkadaeaiaaavqgKPAQVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLAL 322
Cdd:cd00186 67 ------------------------------------KEAVVVSvEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQI 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 323 AQSLYERHKaLTYPRTDSRALPEDYLPVARQTfdMLATSGMRHLAPFAQQAINdnyirptKRVFDNSKVSDHFAIIPTTQ 402
Cdd:cd00186 111 AQKLYEAGL-ITYPRTDSTRLSEEAILEAREY--IQAIYGKEYLYPAPLLGRR-------NPKRGKKEQGAHEAIRPTKV 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 403 AP-----SGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKEGD 477
Cdd:cd00186 181 APtpeleANLSEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEEPPPLK 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 478 KGQPLVAVQPgeqprthhaDVKGLKTKPPARYSEATLLGAMEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKY 557
Cdd:cd00186 261 EGDELKLEEV---------ELEEKETQPPPRYTEASLIKLME----------------KRGIGRPSTYASIIETLLDRGY 315
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 262211437 558 MLREGRELIPTAKAFQLMTLLRGlEVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLV 624
Cdd:cd00186 316 VEKEKKKLIPTELGFAVIELLEK-HFPELVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
5-664 |
2.83e-99 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 330.42 E-value: 2.83e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 5 LVIAEKPSVAQDIVRALTPVAGKFEKHDD--YFE----SDSYVVTSAVGHLVEIQAPEEFdvkrGKWSFANLPVIPPrfd 78
Cdd:PRK07219 3 LIIAEKNNAARRIADILSGGKAKKKRVNGvpYYEferkGEKWIVIGLSGHIVTVDFPEEY----GDWRDVDPAELID--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 79 lKPVDKTKTR---LNAVVKQAKRKDvtELINACDAGREGELI----FRLIEQyaggakgGLGKPVKRLWLQSMTPQAIRD 151
Cdd:PRK07219 76 -ADPVKKITKqnyINALKKLAKDAD--EIIIATDYDREGELIgkeaYHILRE-------VCQVPVKRARFSSLTKKEIRK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 152 GFNNLrsDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEV 231
Cdd:PRK07219 146 AFENP--DEIDFNLADAGEARQIIDLYWGAALTRFLSLSVRQLGRWDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 232 HGTFDAQAgQYLGKWFnpqwkkSDDAEAkaDRLWNKADAEAIAAAVQG-KPAQVTEESKPTTQASPLL-FDLTSLQREAN 309
Cdd:PRK07219 224 EALLDKEA-QYFYRDL------IGGHEA--EKFWDEEEAEEIYEKLKGaKEATVSSVKKRERTISPPApFNTTEFLREAS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 310 GKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDYLPVarqtfDML-ATSGMRHLAPFAQQAINDNYIRPTKRVFDN 388
Cdd:PRK07219 295 KIFGISPKRAMEIAEKLYTA-GYISYPRTDNTVYPDDLDPK-----ELLkKLSKKKEYGPYAESILEQENIKPTEGKKET 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 389 SkvsDHFAIIPTTQAPSG-LSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAA 467
Cdd:PRK07219 369 T---DHPPIHPVDVPKREeLSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKF 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 468 NEVE--DAKEGDKgqplVAVQPGEQPRThhadvkglKTKPPARYSEATLLgamesagkqidddelrEAMQEKGLGTPATR 545
Cdd:PRK07219 446 DEKElpDLEEGEK----LKVNKIEIEAK--------ETQPPKRYTQSSLI----------------KEMEKRGLGTKATR 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 546 AAIIEGLLTEKYMLrEGRELIPTAKAFQLMTLLRGLeVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQ----IQAMTE 621
Cdd:PRK07219 498 HDIIEKLYKRGYVI-EGDPPRPTDLGIAVIEALEKY-APEIVSEEMTAQLEADMQAIEDGKKKKEDVTEEsremLKEILS 575
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 262211437 622 KLVKKAKE---YDRDTIPGDYATLST--PCPNCGGVV-----KENYRRYACTG 664
Cdd:PRK07219 576 ELKEKRKEigdHLAGSLKAENRSLKTigKCPECGGDLiiirtDKGSRFVGCSG 628
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
3-656 |
1.76e-85 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 289.20 E-value: 1.76e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 3 KTLVIAEKPSVAQDIVRALTPVAGKFEKHD-DYFE----SDSYVVTSAVGHLveiqapeeFDVKRGKWSFanlPVIppRF 77
Cdd:PRK05776 2 YILVIAEKPKAARKIAEALSEKPIRCRIYGvPYWIvkrdGKKIVVAPAAGHL--------FGLHTKSKGF---PVF--DY 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 78 DLKP---VDK----TKTRLNAVVKQAKRKDvtELINACDAGREGELIFRLIEQYAGGAKGGlgkpvKRLWLQSMTPQAIR 150
Cdd:PRK05776 69 EWKPlyeIDKgskyTKKYYELLSSLSKYAD--EFINACDYDIEGSVIGYLIIKYLGDPKKA-----KRMKFSALTKSDIR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 151 DGFNNLRS-DAQMqglASAARSRSEADWLVGINGTRA-MTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDY 228
Cdd:PRK05776 142 RAFRNLETlDYEM---INAGIARHELDWLWGINVSRAlMSSVRDASGKRVILSAGRVQSPTLKYVVEREIERNLFVPLPY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 229 WEVHGTFDAQAGQYLGKWFNPQWKKSDDAEAKADRLWNkadaeaiaaavqGKPAQVTE-ESKPTTQASPLLFDLTSLQRE 307
Cdd:PRK05776 219 FSVSIIIEKNGYEFTLKYENKKFETKEEAKEILEEIKK------------TGYLKVTKvEVKIEILEPPPPFNLGDLQVE 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 308 ANGKFGFSAKTTLALAQSLYERhkALT-YPRTDSRALPE--DYlpvaRQTFDMLA-TSGMRHLApfaqqainDNYIRPTK 383
Cdd:PRK05776 287 AARIYGFSPYKTQSIAEDLYLD--GLIsYPRTNSQKLPPtlNI----RNILKGLSrSPQYRPLV--------NLLLKETK 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 384 RVF--DNSKVSD--HFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSA--EYQVTTRISKVEQHSFKTEGKVLVKPG 457
Cdd:PRK05776 353 GVLkpVQGPKDDpaHPAIYPTGEPPKNLSKDEFKLYDLIVRRFLASFAAPAvlSNTIVTLRVPGFPLVFSASGQRIEERG 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 458 WLAIYGKEAANEVEdakegdkgqpLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESagkqidddelreamqeK 537
Cdd:PRK05776 433 WLKYYPFHKFDEEE----------LPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMES----------------V 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 538 GLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLeVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQ 617
Cdd:PRK05776 487 GIGTEATRARIIETLFKRGYLTSNGKYIEVTPLGFGVAEVLEKY-FPDIVSVELTRDFEEKLEMIRTGKATREEVIEEAK 565
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 262211437 618 AMTEKLVKKAKEYDRD--TIPGDYATLSTP---CPNCGGVVKEN 656
Cdd:PRK05776 566 ETLNKLLEEFKKNKDEigEELAKALGLIKPvgkCKICGREAYKD 609
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
7-658 |
9.15e-80 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 272.09 E-value: 9.15e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 7 IAEKPSVAQDIVRALTPVAGKFEKHDD--YFE----SDSYVVTSAVGHLVEIQAPEEfdvkrgkwsfANLPVipprFDLK 80
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSDGRVLKKSEYGvpYWEvrrdGKKIIVASAVGHLFGLHPKSR----------GGYPV----FDIE 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 81 --PV---DKTKTRLNAVVKQAKR--KDVTELINACDAGREGELIfrlieQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGF 153
Cdd:TIGR01057 67 wvPIfefDKGKGYVSKYIKALSKlaKGADEYINACDYDIEGEVI-----GFKALKYFCGVERAKRMKFSTLTKQDIRRAY 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 154 NNLrsDAQMQGLASAARSRSEADWLVGINGTRA-MTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVH 232
Cdd:TIGR01057 142 ANP--EEIDYGMVDAGMARHILDWYWGINLSRAlMEAIRAAAGRWVILSAGRVQGPTLAFLVEREREINLFVPKPYWVIK 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 233 GTFDAQAGQYlgkwfnpqwkksdDAEAKADRLWNKADAEAIAAAVQGKP-AQVTE-ESKPTTQASPLLFDLTSLQREANG 310
Cdd:TIGR01057 220 ATLEKGGGVF-------------DARPEKWKIWSEEEAKSIKEELKKSPwAAVEEvRSERSILKPPPPFDLGTLQREAYR 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 311 KFGFSAKTTLALAQSLYErhKALT-YPRTDSRALPED--YlpvaRQTFDMLATsgMRHLAPFAQQAINDNYIRPTkrvfD 387
Cdd:TIGR01057 287 IFGFSPKKTQSIAQELYE--EALIsYPRTSSQKLPPSinY----RAILDNLAK--GPLYREAAERLLETGVLKPV----E 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 388 NSKVSD-HFAIIPTTQAPSG-LSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKE 465
Cdd:TIGR01057 355 GKKEDPaHPAIHPTGEIPSQeLSKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYS 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 466 AANEVedakegdkgqPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESagkqidddelreamqeKGLGTPATR 545
Cdd:TIGR01057 435 KFEEK----------ELPPLDRGDKIKVVRVDVRVKETQPPARYDKASLIREMES----------------RGLGTKATR 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 546 AAIIEGLLTEKYMLREGR-ELIPTAKAFqLMTLLRglEVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLV 624
Cdd:TIGR01057 489 ARIIETLYKRGYIEGKKSiKVTPLGEAV-IETLQR--YCPEIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKIL 565
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 262211437 625 KKAKEYDRDTIPGDYATLST-----PCPNCGG--VVKENYR 658
Cdd:TIGR01057 566 EEFKKRLDDIGIELGKSLGSvevvgKCPKCGGklVSKYAKK 606
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
5-682 |
2.67e-68 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 243.13 E-value: 2.67e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 5 LVIAEKPSVAQDIVRALTPVAGKFEKHD--DYFE----SDSYVVTSAVGHLVEIQAPEEFDvkrgkwsfaNLPVIPPRfD 78
Cdd:PRK07220 3 LIITEKNIAARRIAQILAPKKPKKTRVSgvDVYRyednGDDTVVVGLSGHIVNIDFPKEYN---------NWQKVDAR-D 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 79 LKPVDKTKTRLNAVVKQAKR---KDVTELINACDAGREGELIFrlIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNN 155
Cdd:PRK07220 73 LIDAEIITTPTQKKIVTALKklgKEADRVTIATDYDREGELIG--VEALNIIKKVNPDIKFDRVRYSAITKKEIERAFSN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 156 LRS-DAQmqgLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTtVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGT 234
Cdd:PRK07220 151 PVEvDFN---LADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLS-VGRVQSPTLALIVDREKEREAFVPTPYWEIYAT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 235 FdaqagQYLGKWFNPQWKKSDDAE-AKADRLWNKAdaeaiaaavqGKPAQVTE-ESKPTTQASPLLFDLTSLQREANgKF 312
Cdd:PRK07220 227 L-----ENNGETFVAQHSTRRFWEkEEADRVFEKL----------GKTAEVTEvEKGTKTDKPPTPFNTTEFISAAN-SI 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 313 GFSAKTTLALAQSLYErHKALTYPRTDSRALPEdylpvarqTFDMLATSGMRHLAPF---AQQAINDNYIRPTKrvfDNS 389
Cdd:PRK07220 291 GFSAANAMRIAESLYT-NGYISYPRTDNTVYPE--------SLDLREQIEIFAEGPFgeyAQKLLEKGELVPTR---GKK 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 390 KVSDHFAIIPTTQAP-SGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAAN 468
Cdd:PRK07220 359 ETTDHPPIYPASLAKkSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAPE 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 469 EVEdakegdkgqpLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMEsagkqidddelreamqEKGLGTPATRAAI 548
Cdd:PRK07220 439 DRL----------LPELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLME----------------DLGLGTKATRHEI 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 549 IEGLLTEKYMlrEGRELIPTAKAFQLMTLLRGLeVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLV---- 624
Cdd:PRK07220 493 ISKLYSRAYI--HGNPIQPTNTAFAVVDALEKY-APTITKPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVFdeld 569
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262211437 625 ---KKAKEYDRDTIPGDyaTLSTPCPNCGG--VVKENYRRYACTGANGASEgCGFSFTKSPAG 682
Cdd:PRK07220 570 knrEKIRESLREGLRED--KIIGKCPLCGSdlMVRRSKRGSRFIGCEGYPE-CTFSLPLPKSG 629
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
287-574 |
1.11e-66 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 224.05 E-value: 1.11e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 287 ESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYErHKALTYPRTDSRALPEDYLPVARQtfdmlatsGMRHL 366
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYE-KGLITYPRTDSTRLSEEAVLEARN--------YIQKL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 367 APFAQQAINDNYIRPTKRVFDNSKVSDHFAIIPTTQAPS-----GLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKV 441
Cdd:smart00437 72 YGKEYLDLAVVLLKPRKPRKGKKAQGAHEAIRPTKPIFTpelekELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 442 EQHSFKTEGKVLVKPGWLAIYGKEAANEvedakegdkGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMEsa 521
Cdd:smart00437 152 GGEKFKAKGKTLLFDGWLKVYPEEKKEE---------EIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLME-- 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 262211437 522 gkqidddelreamqEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQL 574
Cdd:smart00437 221 --------------KRGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
3-650 |
8.50e-58 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 214.27 E-value: 8.50e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 3 KTLVIAEKPSVAQDIVRALtpvaGKfekhddyfesdSYVVTSAVGH---LVEIQAPEEFDVKRGKWS---------FANL 70
Cdd:PRK07561 2 KSLVIVESPAKAKTINKYL----GS-----------DYVVKASVGHirdLPTSASSVPAKEKGALWArmgvdpdhdFEAL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 71 PVIPPrfdlkpvDKTKtrlnaVVKQAKR--KDVTELINACDAGREGELI-FRLIEqyaggAKGGLGKPVKRLWLQSMTPQ 147
Cdd:PRK07561 67 YEVLP-------GKEK-----VVSELKKaaKDADELYLATDPDREGEAIaWHLLE-----VLGGDDVPVKRVVFNEITKN 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 148 AIRDGFNNLRS------DAQMqglasaarSRSEADWLVGINGT--------RAMTAfnsrdggfflttvGRVQTPTLSLV 213
Cdd:PRK07561 130 AIQEAFENPREldinlvNAQQ--------ARRFLDRLVGYMVSpllwkkiaRGLSA-------------GRVQSVAVRLI 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 214 VEREEKIRKFVSRDYWEVHGTFDAQAGQ--------YLGKWFNPQWKKSddaEAKADRLwnkadaeaiAAAVQGKPAQVT 285
Cdd:PRK07561 189 VEREREIEAFVPEEYWDIHADLTTPRGDafearlthLDGKKFAPVDLLN---EAQAEAA---------VAALEGARYSVA 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 286 E-ESKPTTQ--ASPLlfdLTS-LQREANGKFGFSAKTTLALAQSLYER-HkaLTYPRTDSRALPEDYLPVARQtfdmlat 360
Cdd:PRK07561 257 SvEDKPTTRkpSAPF---TTStLQQEASRKLGFSVKKTMRIAQRLYEAgY--ITYMRTDSTNLSQEAINAARG------- 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 361 sgmrhlapFAQQAINDNYIRPTKRVFdNSKVSD----HFAIIPT--TQAP---SGLSEAEQKLYDLVVRRFMAVFFPSAE 431
Cdd:PRK07561 325 --------YIGDNYGKKYLPEKPRQY-SSKAKNaqeaHEAIRPSdvFRTPdqlKGLEGDAQRLYELIWKRFVASQMAPAR 395
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 432 YQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGkeaanEVEDAKEGDKGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSE 511
Cdd:PRK07561 396 YDSTTVTIAAGDAELRATGRVLRFDGFLKVYV-----EGRDDALDDEDRRLPALKVGDALTLEKLDPTQHFTKPPARYSE 470
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 512 ATLLGAMEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLrglevEE----LC 587
Cdd:PRK07561 471 ASLVKELE----------------KLGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRL-----EEffprLV 529
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262211437 588 RADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKE--YDRDTIPGDYATLSTPCPNCG 650
Cdd:PRK07561 530 DYDFTARMEEELDDIANGEADWKPVLDDFYKDFSQQLEKAEElrEEGGMRPNQMVITDRDCPTCG 594
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-672 |
8.29e-55 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 202.78 E-value: 8.29e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 1 MTKTLVIAEKPSVAQDIvraltpvagkfEKhddyFESDSYVVTSAVGHLVEIQAPE-EFDVKRGkwsFAnlpvipPRFDL 79
Cdd:PRK06599 1 MAKKLVIVESPAKAKTI-----------KK----YLGKDYKVLASFGHVRDLPKKKgGVDPDND---FA------PKYEI 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 80 KPvdKTKTRLNAVVKQAKRKDvtELINACDAGREGELI-FRLIEqyAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNNLRS 158
Cdd:PRK06599 57 IE--GKEKVVDALKKAAKKAD--AVYLATDPDREGEAIaWHIAE--VLKEAKLKDKNVKRVVFNEITKKAVQEAIENPRD 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 159 ------DAQmqglasaaRSRSEADWLVGIN--------GTRAMTAfnsrdggfflttvGRVQTPTLSLVVEREEKIRKFV 224
Cdd:PRK06599 131 idmdlvDAQ--------QARRALDYLVGFKlspllwkkVRRGLSA-------------GRVQSVALRLICEREDEIEAFI 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 225 SRDYWEVHGTFDAQAGQ----YLGKWFNpqwKKSDD----AEAKADRLwnkadaeaiAAAVQGKPAQVTE-ESKPTTQAS 295
Cdd:PRK06599 190 PQEYWTIEADLATSNGEpftaKLVEVNG---KKLEKfsitNEEQAKAL---------VKALEGQAYTVDKiEKKERKRNP 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 296 PLLFDLTSLQREANGKFGFSAKTTLALAQSLYE------RHKAL-TYPRTDSRALPEDYLPVARQtfdmlatsgmrhlap 368
Cdd:PRK06599 258 PPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEgidlgeGTVGLiTYMRTDSVRLSNEALDEARK--------------- 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 369 FAQQAINDNYIRPTKRVFDNSK--VSD-HFAIIPT--TQAPSGLS---EAEQ-KLYDLVVRRFMAVFFPSAEY-QVTTRI 438
Cdd:PRK06599 323 YITKKYGKEYLPAKPRVYKKKSknAQEaHEAIRPTsiNRTPESLKpylTPDQfKLYELIWKRTVASQMAPAILdQTSVDI 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 439 SKVEQ-HSFKTEGKVLVKPGWLAIYGKEaanevEDAKEGDKGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGA 517
Cdd:PRK06599 403 ASENGkYVFRATGSVILFPGFLKVYGES-----KDDEEEDDEKLLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKK 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 518 MEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAkafqlmtllRGLEVEELCRA-------- 589
Cdd:PRK06599 478 LE----------------EYGIGRPSTYASIISTLQDREYVELEKKRFIPTD---------LGRIVNDFLVEhfpkyvdy 532
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 590 DLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATlSTPCPNCGG---VVKenyrryacTGAN 666
Cdd:PRK06599 533 DFTAGLEDELDEIAEGKKDWKPVLREFWEPFISNLEKVEEDVRTEKVTQEET-DETCPKCGGgplVLK--------LGKN 603
|
....*.
gi 262211437 667 GASEGC 672
Cdd:PRK06599 604 GKFLGC 609
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
5-651 |
9.05e-49 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 187.75 E-value: 9.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 5 LVIAEKPSVAQDIVRAL---TPVAGKFEKHDDYFESDSYVVTSAVGHLVEIqapeEFDVKRGKW-SFANLP--VIPPRFD 78
Cdd:PRK14973 3 LIIAEKNIAANRIAQILagkTKVQVKKDGGVSTYSFDDTVVVGLRGHVVEV----DFEPGYTNWrSEEHTPrsLIDADTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 79 LKPVDKTKTRLnaVVKQAKRKDVTELinACDAGREGELIFRliEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNNLrS 158
Cdd:PRK14973 79 KKPTEKKIVGL--IQKLAKKADRVTI--ATDFDTEGELIGK--EAYELVRAVNPKVPIDRARFSAITKEEIVTAFAEP-T 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 159 DAQMQgLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTtVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQ 238
Cdd:PRK14973 152 DLDFA-LAAAGEARQIIDLIWGASLTRFISLAAHRGGDNILS-VGRVQSPTLAMIVDREKEIEAFVPEKYWMLSLATEKD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 239 AGQYLGKWFNPQWKKSDDAEAKADRlwnkadaeaiaaavQGKPAQVTEESKPTTQ-ASPLLFDLTSLQREAnGKFGFSAK 317
Cdd:PRK14973 230 GEGIEARHTHGRFTDSAAAEAAYDA--------------TKEPLVVTEVKEGHKVdRAPTPFDTTTFIVAA-SRLGFSAA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 318 TTLALAQSLYeRHKALTYPRTDSRALPEDyLPVARQtfdmLATsgMRHlAPFAQQAIndnYIRPTKR-VFDNSKVS--DH 394
Cdd:PRK14973 295 NAMRIAEDLY-MNGYISYPRTDNTIYPKS-LDLNGV----LAT--LAK-GAFSKDVA---WVKDNRRpVPTRGKKSstDH 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 395 FAIIPTTQAP-SGLSEAEQKLYDLVVRRFMAVFFPSAEYQvTTRIS-KVEQHSFKTEGKVLVKPGWLAIYgkeaanEVED 472
Cdd:PRK14973 363 PPIHPTGVATrEELGDDRWKLYELVVRRFLATLSPDAEWA-TMKVNfDAGGEPYTATGGRLLEAGWRTVY------PYSE 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 473 AKEgdkgQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMEsagkqidddelreamqEKGLGTPATRAAIIEGL 552
Cdd:PRK14973 436 AKE----NILPAFALGEKLPILAVNLEEKETQPPARYSQSRLIQRME----------------ELGLGTKSTRHEVIGKL 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 553 LTEKYMlrEGRELIPT--AKAfqlmtLLRGLE--VEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMT----EKLV 624
Cdd:PRK14973 496 VSRKYI--EGNPLRPTlvGRA-----VTESLEehAGTITEPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLhrafDELE 568
|
650 660
....*....|....*....|....*....
gi 262211437 625 KKAKEYDRDtIPGDYATLST--PCPNCGG 651
Cdd:PRK14973 569 ANEAVIGRD-IMERTAEELTigPCPVCGK 596
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
1-568 |
4.02e-48 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 184.58 E-value: 4.02e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 1 MTKTLVIAEKPSVAQDIVRALTPvagkfekhddyfesdSYVVTSAVGHLVEIqAPEE--FDVKRGkwsFANlpvippRFD 78
Cdd:PRK08780 1 MSKHLVIVESPAKAKTINKYLGK---------------DFTVLASYGHVRDL-VPKEgaVDPENG---FAM------RYD 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 79 LkpVDKTKTRLNAVVKQAKRKDvtELINACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNNLRS 158
Cdd:PRK08780 56 L--IDKNEKHVEAIAKAAKSAD--DLYLATDPDREGEAISWHLAEILKERGLLKDKPMQRVVFTEITPRAIKEAMAKPRD 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 159 DAQmqGLASAARSRSEADWLVGIN--------GTRAMTAfnsrdggfflttvGRVQTPTLSLVVEREEKIRKFVSRDYWE 230
Cdd:PRK08780 132 IAS--DLVDAQQARRALDYLVGFNlspllwrkIQRGLSA-------------GRVQSPALRMIVEREEEIEAFIAREYWS 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 231 VHGTFDAQAGQYLGKWFNPQWKK--------SDDAEAKADRLwnkadaeaiAAAVQG--KPAQVTEESKPTTQASPllFD 300
Cdd:PRK08780 197 IEADCAHPSQPFNAKLIKLDGQKfeqftitdGDTAEAARLRI---------QQAAQGtlHVTDVESKERKRNPAPP--FT 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 301 LTSLQREANGKFGFSAKTTLALAQSLYE--------RHKALTYPRTDSRALPED----------------YLPVARQTFD 356
Cdd:PRK08780 266 TSTLQQEASRKLGFTTRRTMQVAQKLYEgvdlgdegSVGLITYMRTDSVNLSQDalaeirdviardygtaSLPDQPNTYK 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 357 MLATSgmrhlapfAQQAinDNYIRPTKRVFDNSKVSDHfaiipttqapsgLSEAEQKLYDLVVRRFMAV-FFPSAEYQVT 435
Cdd:PRK08780 346 TKSKN--------AQEA--HEAVRPTSALRTPAQVARF------------LSDDQRRLYELIWKRAVACqMIPATLNTVS 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 436 TRISKVEQHSFKTEGKVLVKPGWLAIY--GKEAANevedAKEGDKGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEAT 513
Cdd:PRK08780 404 VDLAAGSEHVFRATGSTVVVPGFLAVYeeGKDDKS----AEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEAS 479
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 262211437 514 LLGAMEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKYMLREGRELIPT 568
Cdd:PRK08780 480 LVKALE----------------EYGIGRPSTYASIISTLQFRKYVEMEGRRFRPT 518
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-973 |
3.76e-47 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 182.33 E-value: 3.76e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 1 MTKTLVIAEKPSVaqdiVRALTPVAGKfekhddyfesdSYVVTSAVGHLVEIQApEEF--DVKRGkwsfanlpvIPPRFD 78
Cdd:PRK06319 1 MKKSLIIVESPAK----IKTLQKLLGE-----------GFIFASSLGHIVDLPA-KEFgiDIEND---------FEPDYQ 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 79 LKPvDKTKTrLNAVVKQAKRKDVTELinACDAGREGELIFRLIEQYAGGAKGglgkpVKRLWLQSMTPQAIRDGFNNLRs 158
Cdd:PRK06319 56 ILP-DKEEV-INKICKLAKKCDVVYL--SPDPDREGEAIAWHIANQLPKNTK-----IQRISFNAITKGAVTEALKHPR- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 159 DAQMqGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFfltTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHG----- 233
Cdd:PRK06319 126 EIDM-ALVNAQQARRLLDRIVGYKISPILSRKLQRRSGV---SAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVhlkdp 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 234 ----TFDAQAGQYLGKWFN---PQWKKSDD-----AEAKADRLwnkadaeaiAAAVQGKPAQVTE-ESKPTTQASPLLFD 300
Cdd:PRK06319 202 ktqkTFWAHLYSVDGKKWEkeiPEGKTEDEvllinSKEKADHI---------VELLESATYTVTRvESKEKRRNAYPPFI 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 301 LTSLQREANGKFGFSAKTTLALAQSLYE--------RHKALTYPRTDS-RALPEdylpvarqtfdmlATSGMRHlapFAQ 371
Cdd:PRK06319 273 TSTLQQEASRHFRFSSSRTMNIAQTLYEgvdldsegATGLITYMRTDSvRTDPE-------------ALKQVRK---YIE 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 372 QAINDNYIRPTKRVFDNSKVSD--HFAIIPT--TQAP----SGLSEAEQKLYDLVVRRFMAVFFPSAEYQ-VTTRISKVE 442
Cdd:PRK06319 337 GTFGKEFLPSSPNVYTTKKMAQdaHEAIRPTdiTLTPeklrSKLTEDQYKLYSLIWKRFVASQMIPAIYDtLAIRITTNK 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 443 QHSFKTEGKVLVKPGWLAIYgKEAANEVEDAKEgdkGQPLvavqpgeqPRTHHADVKGLK--------TKPPARYSEATL 514
Cdd:PRK06319 417 GIDLRATGSLLKFKGFLAVY-EEKRDDEGDEEE---NIHL--------PKLHEQDVLTKEelsaeqafTKPLPRFTEASL 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 515 LGAMESAgkqidddelreamqekGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLR-------------GL 581
Cdd:PRK06319 485 VKELEKS----------------GIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIISQFLEtnfprimdigftaLM 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 582 EVEELCRADLTGEWEFKLSQMEKGQL------SREAFMQQIqaMTE---------KLVK-------------------KA 627
Cdd:PRK06319 549 EDELELIADNKKPWKLLLQEFWELFLpvvvtaEKEAFIPRI--VTEidcpkchkgKLVKiwaknryfygcseypecdyKT 626
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 628 KE----YDRDtipgDYAT---LSTPCPNCGGVVKENYRRYactganGASEGCgfsfTKSPAGRtfetaeaeqllrerriG 700
Cdd:PRK06319 627 SEeeltFNKE----DYAEdtpWDSPCPLCGGEMKVRHGRF------GTFLGC----ENYPECR----------------G 676
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 701 PLEGFRskagwpfvaevaivRDEENSNfklefdfgddkdsedtgeivdfahQQSLGPCPK--CGSPVFEHGAN-----YV 773
Cdd:PRK06319 677 IINIHK--------------KGEEGIE------------------------PEETVPCPAigCTGHIVKRRSRfnkmfYS 718
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 774 CSkavptlaqTTPSCDfksgqiILQQPIEREQmSKLLQTGKTDLLEKfvsnrtrrnfkaflvwdGAAGKVNFEFEQREGK 853
Cdd:PRK06319 719 CS--------EYPACS------VIGNSIDAVI-TKYAGTPKTPYEKK-----------------TKAKKKSASTKGKAAK 766
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 854 YPARktagaaaaktttaaakktgtaakktaaKTATKTAAVKKPRTVsATLKPSADLAAVIGSEPTSRPDVIKKLWDYIKA 933
Cdd:PRK06319 767 TVKK---------------------------KSKAKSKKTTKKRAG-PLYTPSPALAAMIGAEPVGRGEATKKVWDYIKE 818
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|
gi 262211437 934 NGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKHV 973
Cdd:PRK06319 819 HGLQSPENKKLIIPDSKLQGVIGPDPIDMFQLSKKLSQHL 858
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
3-156 |
5.96e-47 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 164.71 E-value: 5.96e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 3 KTLVIAEKPSVAQDIVRAL---TPVAGKFEKHDDYFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANlPVIPPRFDL 79
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILgggSKKKGKGRYYEFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLED-PLFPAPFKL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 262211437 80 KPVDKTKTRLNAVVKQAKRKDvtELINACDAGREGELIFRLIEQYaggAKGGLGKPVKRLWLQSMTPQAIRDGFNNL 156
Cdd:cd03362 80 KVDKGKKKQFKVLKKLAKRAD--EIVIATDADREGELIGREILEY---AKCVKRKPVKRAWFSSLTPKAIRRAFKNL 151
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
3-156 |
2.17e-39 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 142.75 E-value: 2.17e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 3 KTLVIAEKPSVAQDIVRALtpvAGKFEKHDDYFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWsfaNLPVIPPRFDLKPV 82
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKIL---GKGSKKKGFYGEGGGYVVTASVGHLLELPFPEEYVDWDKDW---PLELFPFEPKYVVI 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262211437 83 DKTKTRLNAVVKQAKRKDvtELINACDAGREGELIFRLIEQYaggaKGGLGKPVKRLWLQSMTPQAIRDGFNNL 156
Cdd:cd01028 75 PDKKKQLKALKKLAKKAD--EIVLATDPDREGELIAWEILEV----LKCDNKPVKRAWFSEITPKAIREAFKNL 142
|
|
| Rsc6 |
COG5531 |
DNA-binding SWIB/MDM2 domain [Chromatin structure and dynamics]; |
903-974 |
3.92e-37 |
|
DNA-binding SWIB/MDM2 domain [Chromatin structure and dynamics];
Pssm-ID: 444282 [Multi-domain] Cd Length: 85 Bit Score: 133.91 E-value: 3.92e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262211437 903 LKPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVF-GKEQISMFELAGIVGKHVS 974
Cdd:COG5531 13 LTPSAELAAVVGAKPLPRTEVTKKVWDYIKKNNLQDPANKRNINADAKLKKVFgGKDQVSMFEMTKLVSKHLK 85
|
|
| SWIB-MDM2_like |
cd10567 |
SWIB/MDM2 domain found in SWIB/MDM2 homologous proteins; This family includes ... |
903-973 |
3.59e-30 |
|
SWIB/MDM2 domain found in SWIB/MDM2 homologous proteins; This family includes Schizosaccharomyces pombe upstream activation factor subunit spp27, Saccharomyces cerevisiae upstream activation factor subunit UAF30, Chlamydiae DNA topoisomerase/SWIB domain fusion protein, Arabidopsis thaliana zinc finger CCCH domain-containing proteins, AtC3H19 and AtC3H44, and similar proteins. S. pombe spp27, also termed upstream activation factor 27 KDa subunit (p27), or upstream activation factor 30 KDa subunit (p30), or upstream activation factor subunit uaf30, is a component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. S. cerevisiae UAF30, also termed upstream activation factor 30 KDa subunit (p30), is a non-essential component of the UAF. It seems to play a role in silencing transcription by RNA polymerase II. The SWIB domain found in Chlamydiae DNA topoisomerase may play a role in chromatin condensation-decondensation, which is characteristic of the chlamydial developmental cycle and not found in any other types of bacteria. AtC3H19, also termed protein needed for RDR2-independent DNA methylation (NERD), is a plant-specific GW repeat- and PHD finger-containing protein that plays a central role in integrating RNA silencing and chromatin signals in 21 nt small-interfering RNA (siRNA)-dependent DNA methylation on the cytosine pathway, leading to transcriptional gene silencing of specific sequences. This family also includes many uncharacterized proteins containing two copies of SWIB/MDM2 domain.
Pssm-ID: 349489 [Multi-domain] Cd Length: 71 Bit Score: 113.79 E-value: 3.59e-30
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262211437 903 LKPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKHV 973
Cdd:cd10567 1 YKLSPELAAFLGVSELSRTEVVKKLWAYIKENNLQDPKNKREILCDEKLKKVFGKDEVVMFEMNKLLSKHL 71
|
|
| SWIB |
pfam02201 |
SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated ... |
903-972 |
5.52e-30 |
|
SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.
Pssm-ID: 460488 [Multi-domain] Cd Length: 73 Bit Score: 113.35 E-value: 5.52e-30
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 903 LKPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKH 972
Cdd:pfam02201 3 FKLSPELAELLGEEELSRPEVVKALWEYIKENNLQDPEDKREIICDEKLKKLFGGDRVKFFEMPKLLSPH 72
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
95-571 |
3.55e-28 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 121.97 E-value: 3.55e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 95 QAKRKDVTELINACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNNLRSDAQMQGLASAARSRSE 174
Cdd:PTZ00407 119 EEKADNVTEIILATDPDREGELIAVHALQTIKRLYPKLKVPFSRAYMHSITEDGIRKAMRERHVEACDYDLANAAETRHA 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 175 ADWLVGINGTRAMTAFNSRdggffLTTVGRVQTPTLSLVVEREEKIRKFVSRDywevHGTFDAQAGQYL----GKWF--- 247
Cdd:PTZ00407 199 MDRIFGFLGSSVVRAANSQ-----MRSIGRVQTPALILINEREDKIKAFLESN----KSTFEVQAMCQFpsphGTTFsqv 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 248 ---NP-------QWkkSDDAEAKaDRL--WNKADAEAIAAAVQGKPaqvteesKPTTQASPLLFDLTSLQREANGKFGFS 315
Cdd:PTZ00407 270 vtiTPdrkggasHW--ATEAEAR-RCLeqWKLNNCTGFSVPLEPKP-------QPSVVPPPQPFTMATAIAKANRQLKYS 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 316 AKTTLALAQSLYERhKALTYPRTDS-----RALPEDYLPVARQTFDMLATSGMRHLAPFAQQainDNYIRPT-KRVFDNS 389
Cdd:PTZ00407 340 SEMVSGCLQDLFQL-GHITYPRTDStrideSALPDIYAAVKKEFGKEFLYRLEDRTVSAQEG---KGSKKTGkKRSTKQK 415
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 390 KVSD---------HFAIIPT---TQAPS-GLSEAEQKLYDLVVRRFMAVFFPSAEYQ-----VTTRISKVEQHSFKTEGK 451
Cdd:PTZ00407 416 KGADtpvgnvedaHEAIRPTnidTTGESlSLSPPTRAVYDLVRRNTLAVFMIPMKTEkivatVKFTSGSGEKLEFELQGK 495
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 452 VLVKPGWLAIYGKEAANEV-------EDAKEGDKGQPLV----------------AVQPGEQPRT---HHADVKGLKTKP 505
Cdd:PTZ00407 496 RVVEPGWTRAFHKGDKGTTgpaeetdEDITAVEEGAPVVpslsqeefkaimnlrsQLGSGVQKGFfelRSPQVRENRPVP 575
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262211437 506 PARYSEATLLgamesagkqidddelrEAMQEKGLGTPATRAAIIEGLLTEKYMLRE----------GRELIPTAKA 571
Cdd:PTZ00407 576 PLPHSEGTLI----------------EELKNNGVGRPSTYPMIVKTLLARGYIAVNpkgrcettpvGRMLVETAKS 635
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
136-230 |
4.32e-24 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 96.88 E-value: 4.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 136 VKRLWLQSMTPQAIRDGFNNLRS-DAqmqGLASAARSRSEADWLVGINGTRAMTAfNSRDGGFfltTVGRVQTPTLSLVV 214
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREiDE---NLVNAQLARRILDRLIGFNLSRLLTK-KLRNGVL---SAGRVQTPTLGLIV 73
|
90
....*....|....*.
gi 262211437 215 EREEKIRKFVSRDYWE 230
Cdd:smart00436 74 EREREIKNFVPKPYWE 89
|
|
| SWIB |
smart00151 |
SWI complex, BAF60b domains; |
902-972 |
6.56e-24 |
|
SWI complex, BAF60b domains;
Pssm-ID: 128456 [Multi-domain] Cd Length: 77 Bit Score: 96.23 E-value: 6.56e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262211437 902 TLKPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKH 972
Cdd:smart00151 4 KVTLSPELAKVLGAPEMTRTEIIKRLWEYIKEHNLQDPQNKREILCDSKLEQIFGKDRMDMFEMNKLLTPH 74
|
|
| SWIB_like |
cd10568 |
SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling ... |
906-972 |
7.58e-19 |
|
SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling complexes and similar proteins; SWIB domain is a conserved region found within proteins in the SWI/SNF family of complexes. SWI/SNF complex proteins display helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors), among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. The family also includes Saccharomyces cerevisiae transcription regulatory protein SNF12 and remodel the structure of chromatin complex subunit 6 (RSC6), and Schizosaccharomyces pombe SWI/SNF and RSC complexes subunit SSR3. SNF12, also termed 73-kDa subunit of the SWI/SNF transcriptional regulatory complex, or SWI/SNF complex component SWP73, is involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). RSC6 and SSR3 are components of the RSC, which is involved in transcription regulation and nucleosome positioning. RSC6 is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.
Pssm-ID: 349490 [Multi-domain] Cd Length: 69 Bit Score: 81.43 E-value: 7.58e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 262211437 906 SADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKH 972
Cdd:cd10568 2 SPALAQLLGIKEGTRPNIIYALWQYIKLNKLQDPEDRRLINCDEALKQLFGVERFKFSELPELLNPH 68
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
671-735 |
1.76e-16 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 74.44 E-value: 1.76e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262211437 671 GCGFSFTKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFVAEVAIVRDEensnfKLEFDFG 735
Cdd:pfam13342 1 GCGFSIGKTIAGKKLSEEQVKELLTKGKTGLIKGFKSKKGKKFDAYLVLDDDE-----KVEFDFE 60
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
787-848 |
1.29e-15 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 71.74 E-value: 1.29e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262211437 787 SCDFKSGQIILQQPIEREQMSKLLQTGKTDLLEKFVSnRTRRNFKAFLVWDGaAGKVNFEFE 848
Cdd:pfam13342 1 GCGFSIGKTIAGKKLSEEQVKELLTKGKTGLIKGFKS-KKGKKFDAYLVLDD-DEKVEFDFE 60
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
59-664 |
1.16e-12 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 71.82 E-value: 1.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 59 DVKRGKWSFANLPVIPPRFDLKPVDKTKTRLNAVVKQAKRKDVTELINACDAGREGELIFRLIEQYAGGAKGGLGKPVKR 138
Cdd:COG0551 41 KKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAAALAAADDDAIEAAAAADEEEALKAAEALEAIRK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 139 LWLQSMTPQAIRDGFNNLRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQtptlslVVEREE 218
Cdd:COG0551 121 AVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAASRALRLLLLLAAGRLRLLSAVAAGLLELE------ELLKEF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 219 KIRKFVSRDYWEVHGTFDAQAGQYLGKWFNPQWKKSDDAEAKADRLWNKADAEAIAAAVQGKPAQVTEESKPTTQASPLL 298
Cdd:COG0551 195 EEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKKDKEEETKAIKKKKKAAEAVLAAKKAAKEAKAKKELPTTTTDALPE 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 299 FDLTSLQREAngkfgfSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFDMLATSGMRHLAPFAQQAINDNY 378
Cdd:COG0551 275 ALATTSLTAA------AAASALAAALLEEEGELLYTGGYIRYTRTPKSSEADALAALEALKKIAEEPPDERAKKKKKKAK 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 379 IRPTKRVFDnSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGW 458
Cdd:COG0551 349 KKKASEAKE-TTDHPPIPPTTAAALLELLEDRKLLLELLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGLLEVLGE 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 459 LAIYGKEAANEVEDAKEGDKGQPLVAVQPGEQPrthhadvkglKTKPPARYSEATLLGAMEsagkqidddelreamqEKG 538
Cdd:COG0551 428 EEEDDEDEEEELLLPPLEEGEPLLLEELLLEKQ----------TTTPPPRYTTELLLKKLE----------------EEG 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 539 LGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLEVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQA 618
Cdd:COG0551 482 GGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYP 561
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 262211437 619 MTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRY----ACTG 664
Cdd:COG0551 562 FFKKLLEIAEEEGEEELSEEDEVLGEKCPKCGKPLVIKKGRYgkflGCSN 611
|
|
| SWIB-MDM2 |
cd00855 |
SWIB/MDM2 domain family; The SWIB/MDM2 protein domain, short for SWI/SNF complex B/MDM2, has ... |
905-972 |
1.22e-12 |
|
SWIB/MDM2 domain family; The SWIB/MDM2 protein domain, short for SWI/SNF complex B/MDM2, has been found in both SWI/SNF complex B (SWIB) and the negative regulator of the p53 tumor suppressor MDM2, which are homologous and share a common fold. The SWIB domain is a conserved region found within proteins in the SWI/SNF (SWItch/Sucrose Non-Fermentable) family of complexes. SWI/SNF complex proteins display helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors). MDM2 is an inhibitor of p53 tumor repressor. It binds to the transactivation domain and down-regulates the ability of p53 to activate transcription. This family corresponds to the SWIB domain and the p53 binding domain of MDM2.
Pssm-ID: 349487 [Multi-domain] Cd Length: 69 Bit Score: 63.78 E-value: 1.22e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262211437 905 PSADLAAVIGSEPT-SRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKH 972
Cdd:cd00855 1 LSPELEALLKSYETfTLKEILQALWQYIKKKNLMDPDDPSIVVCDERLRQLFEVPSFPFSEIPKALKKH 69
|
|
| SWIB_BAF60A |
cd17674 |
SWIB domain found in BRG1-associated factor 60A (BAF60A) and similar proteins; BAF60A, also ... |
909-965 |
2.01e-07 |
|
SWIB domain found in BRG1-associated factor 60A (BAF60A) and similar proteins; BAF60A, also termed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1), or 60 kDa BRG-1/Brm-associated factor subunit A, or SWI/SNF complex 60 kDa subunit, is a core subunit of the SWI/SNF chromatin-remodeling complex that activates the transcription of fatty acid oxidation genes during fasting. BAF60A is involved in chromatin remodeling and hepatic lipid metabolism. It mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. It is also a key component of the transcriptional control in cardiac progenitors. Moreover, BAF60A interacts with p53 to recruit the SWI/SNF complex, suggesting that the SWI/SNF chromatin remodeling complex is involved in the suppression of tumors.
Pssm-ID: 349493 Cd Length: 77 Bit Score: 49.43 E-value: 2.01e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 262211437 909 LAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFEL 965
Cdd:cd17674 8 LARLLGIHTQTRPVIINALWQYIKTHKLQDPHEREYINCDKYLQQIFECQRMKFSEI 64
|
|
| SWIB_BAF60C |
cd17676 |
SWIB domain found in BRG1-associated factor 60C (BAF60C) and similar proteins; BAF60C, also ... |
909-965 |
1.22e-06 |
|
SWIB domain found in BRG1-associated factor 60C (BAF60C) and similar proteins; BAF60C, also termed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (SMARCD3), or 60 kDa BRG-1/Brm-associated factor subunit C, is a core subunit of the SWI/SNF chromatin-remodeling complex that activates the transcription of fatty acid oxidation genes during fasting. It is involved in chromatin remodeling and hepatic lipid metabolism. It is also essential for cardiomyocyte differentiation at the early heart development. Moreover, BAF60C drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Furthermore, BAF60C epigenetically regulates epithelial-mesenchymal transition (EMT) by activating WNT signaling pathways.
Pssm-ID: 349495 Cd Length: 74 Bit Score: 46.90 E-value: 1.22e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 262211437 909 LAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFEL 965
Cdd:cd17676 5 LARLLGIHTQTRSAIIQALWQYIKTNKLQDSHDKEYINCDKYFQQIFDCPRLKFSEI 61
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
202-607 |
9.01e-06 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 49.81 E-value: 9.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 202 VGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAGQYLGKWFNPQWKKSDDAEAKADRLWNKADAEAIAAAVQGKP 281
Cdd:COG1754 178 RRRRRRRARRRELERRRERARAAEAEEAAAAAAAAADAGRAAAARDGKGGGKLAAGGAAAAAAAAAAAAAAAAALAEAAA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 282 AQVTEESKPTTQASPLLFDLTSLQREAngkfgfSAKTTLALAQSLYERhkALTYPRTDSRAlpedylpvARQTFDMLATS 361
Cdd:COG1754 258 AAAVREPPTPTTTTTAQAATTTTTRAA------AARTTRSAQQAARRT--RLGGEGTYTTT--------TTTTTTTSAAA 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 362 GMRHLAPFAQQAINDNYIRPTKRVFDNSK----------VSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRF----MAVFF 427
Cdd:COG1754 322 AAAAAAAAALAAAAAAAYAPPPPYYYKKKaaaaaaaaaaAAAAAARRPPAARAALLSDDRLLLELLLLRRTaaaaAAAAA 401
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 428 PSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAANEVE--DAKEGDKGQPLVAVQPGEQPRTHHadvkglkTKP 505
Cdd:COG1754 402 ATATTTAAAAAAGAGAVGTAAAGAVFFFGGFLLFAEEEDDDEEDddDDDLPALEEGLPLLKEGVLADQHF-------TQP 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 506 PARYSEATLLGAMESAGKqidddeLREamqEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLrgleVEE 585
Cdd:COG1754 475 PPRYTEAPLVKRMEELGI------GRP---STYASILSTLADRIYVRLDKRRLIPEDKGRLVTAFLFSFFRRY----VEY 541
|
410 420
....*....|....*....|..
gi 262211437 586 LCRADLtgewEFKLSQMEKGQL 607
Cdd:COG1754 542 DFTADL----EEFLDDVSDGEL 559
|
|
| SWIB_BAF60B |
cd17675 |
SWIB domain found in BRG1-associated factor 60B (BAF60B) and similar proteins; BAF60B, also ... |
904-956 |
1.50e-05 |
|
SWIB domain found in BRG1-associated factor 60B (BAF60B) and similar proteins; BAF60B, also termed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (SMARCD2), or 60 kDa BRG-1/Brm-associated factor subunit B, is a component of the BAF complex. It is involved in transcriptional activation and repression of select genes by chromatin remodeling. It plays a role in the ATM-p53 pathway in sensing chromatin opening by facilitating ATM recruitment to the SWI/SNF complex, as well as ATM activation. It also regulates transcriptional networks controlling differentiation of neutrophil granulocytes. Thus, it acts as a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia.
Pssm-ID: 349494 Cd Length: 80 Bit Score: 44.19 E-value: 1.50e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 262211437 904 KPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFG 956
Cdd:cd17675 6 KLDPRLARLLGVHTQTRANIMQALWLYIKHNKLQDSHEKEYINCNRYFRQIFN 58
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
3-155 |
7.84e-05 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 43.32 E-value: 7.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 3 KTLVIAEKPSVAQDIVRALtpvaGKfekhddyfesdSYVVTSAVGHLVEIqAPEEFDVKrgkwsfanlpviPPRFDLKPV 82
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYL----GK-----------EYEVLASVGHIRDL-PKKGLGVD------------GEDDGFEPK 52
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262211437 83 DKTKTRLNAVVKQAKR--KDVTELINACDAGREGELI----FRLIEQyaggakgglGKPVKRLWLQSMTPQAIRDGFNN 155
Cdd:cd03363 53 YVVIPGKKKVVKELKKlaKKADEIYLATDPDREGEAIawhlAEVLKL---------KKNVKRVVFNEITKEAIKEALKN 122
|
|
| OrfB_Zn_ribbon |
pfam07282 |
Putative transposase DNA-binding domain; This putative domain is found at the C-terminus of a ... |
619-676 |
3.82e-03 |
|
Putative transposase DNA-binding domain; This putative domain is found at the C-terminus of a large number of transposase proteins. This domain contains four conserved cysteines suggestive of a zinc binding domain. Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesize this domain is DNA-binding.
Pssm-ID: 284650 [Multi-domain] Cd Length: 69 Bit Score: 36.81 E-value: 3.82e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 262211437 619 MTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKE--NYRRYACTgangaseGCGFSF 676
Cdd:pfam07282 4 FIEQLEYKAKEYGIKVVEVDPAYTSKTCSVCGHKNKEslSGRTFVCP-------NCGFVA 56
|
|
| |
