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Conserved domains on  [gi|255343456|gb|ACU02782|]
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hypothetical protein Phep_0559 [Pedobacter heparinus DSM 2366]

Protein Classification

HlyD family secretion protein( domain architecture ID 11446287)

HlyD family secretion protein similar to Escherichia coli protein YhiI, Acinetobacter baumannii colistin resistance protein EmrA, and Burkholderia cepacia fusaric acid resistance protein FusE

Gene Ontology:  GO:0022857|GO:0016020|GO:0055085
TCDB:  3.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
25-411 3.32e-21

Multidrug resistance efflux pump EmrA [Defense mechanisms];


:

Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 93.96  E-value: 3.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456  25 AWLLRWGLSVIFAVLILMISLSALIKYPDIVKTQLKITSANAPKSVISKISGQLVKVTVQENQAVITDQPLAYIESTASH 104
Cdd:COG1566    3 ALKKRRLLALVLLLLALGLALWAAGRNGPDEPVTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 105 EQVLQLLDELKNLQANLSEgmiplkllatpknvflgelqnayqsfyqsflmyqssiangfyLKKKVFLQKDLLSILDQKE 184
Cdd:COG1566   83 AALAQAEAQLAAAEAQLAR------------------------------------------LEAELGAEAEIAAAEAQLA 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 185 QLlvqqklqEKDYELGKKEFEMHQKLFEQKVEAPMELKREESKFIAKRYPLQQTESALLSNSIIYSAKEkEIMELENLIS 264
Cdd:COG1566  121 AA-------QAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQAQLEAAQAQLAQAQAGLREEE-ELAAAQAQVA 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 265 EEKLKFIQALNNFisniedwkKKYVLTAPQPGKVAFLgIVQEKEFLNAGQEVLYINPGStDFFGEIHIPQYKMGKVYKDQ 344
Cdd:COG1566  193 QAEAALAQAELNL--------ARTTIRAPVDGVVTNL-NVEPGEVVSAGQPLLTIVPLD-DLWVEAYVPETDLGRVKPGQ 262
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255343456 345 EVLIKLKSYPFEEYgiiRGNIQSIADIPYKDS-----------VFVSRVSISNKGmsglkrNIRLKNGMIADAEIITE 411
Cdd:COG1566  263 PVEVRVDAYPDRVF---EGKVTSISPGAGFTSppknatgnvvqRYPVRIRLDNPD------PEPLRPGMSATVEIDTE 331
 
Name Accession Description Interval E-value
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
25-411 3.32e-21

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 93.96  E-value: 3.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456  25 AWLLRWGLSVIFAVLILMISLSALIKYPDIVKTQLKITSANAPKSVISKISGQLVKVTVQENQAVITDQPLAYIESTASH 104
Cdd:COG1566    3 ALKKRRLLALVLLLLALGLALWAAGRNGPDEPVTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 105 EQVLQLLDELKNLQANLSEgmiplkllatpknvflgelqnayqsfyqsflmyqssiangfyLKKKVFLQKDLLSILDQKE 184
Cdd:COG1566   83 AALAQAEAQLAAAEAQLAR------------------------------------------LEAELGAEAEIAAAEAQLA 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 185 QLlvqqklqEKDYELGKKEFEMHQKLFEQKVEAPMELKREESKFIAKRYPLQQTESALLSNSIIYSAKEkEIMELENLIS 264
Cdd:COG1566  121 AA-------QAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQAQLEAAQAQLAQAQAGLREEE-ELAAAQAQVA 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 265 EEKLKFIQALNNFisniedwkKKYVLTAPQPGKVAFLgIVQEKEFLNAGQEVLYINPGStDFFGEIHIPQYKMGKVYKDQ 344
Cdd:COG1566  193 QAEAALAQAELNL--------ARTTIRAPVDGVVTNL-NVEPGEVVSAGQPLLTIVPLD-DLWVEAYVPETDLGRVKPGQ 262
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255343456 345 EVLIKLKSYPFEEYgiiRGNIQSIADIPYKDS-----------VFVSRVSISNKGmsglkrNIRLKNGMIADAEIITE 411
Cdd:COG1566  263 PVEVRVDAYPDRVF---EGKVTSISPGAGFTSppknatgnvvqRYPVRIRLDNPD------PEPLRPGMSATVEIDTE 331
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
289-401 1.47e-12

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 63.54  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456  289 VLTAPQPGKVAFLGiVQEKEFLNAGQEVLYINPGSTdFFGEIHIPQYKMGKVYKDQEVLIKLKSYPfeEYgIIRGNIQSI 368
Cdd:pfam13437   1 TIRAPVDGVVAELN-VEEGQVVQAGDPLATIVPPDR-LLVEAFVPAADLGSLKKGQKVTLKLDPGS--DY-TLEGKVVRI 75
                          90       100       110
                  ....*....|....*....|....*....|....
gi 255343456  369 ADIPYKD-SVFVSRVSISNKGMSglkrnIRLKNG 401
Cdd:pfam13437  76 SPTVDPDtGVIPVRVSIENPKTP-----IPLLPG 104
 
Name Accession Description Interval E-value
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
25-411 3.32e-21

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 93.96  E-value: 3.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456  25 AWLLRWGLSVIFAVLILMISLSALIKYPDIVKTQLKITSANAPKSVISKISGQLVKVTVQENQAVITDQPLAYIESTASH 104
Cdd:COG1566    3 ALKKRRLLALVLLLLALGLALWAAGRNGPDEPVTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 105 EQVLQLLDELKNLQANLSEgmiplkllatpknvflgelqnayqsfyqsflmyqssiangfyLKKKVFLQKDLLSILDQKE 184
Cdd:COG1566   83 AALAQAEAQLAAAEAQLAR------------------------------------------LEAELGAEAEIAAAEAQLA 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 185 QLlvqqklqEKDYELGKKEFEMHQKLFEQKVEAPMELKREESKFIAKRYPLQQTESALLSNSIIYSAKEkEIMELENLIS 264
Cdd:COG1566  121 AA-------QAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQAQLEAAQAQLAQAQAGLREEE-ELAAAQAQVA 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456 265 EEKLKFIQALNNFisniedwkKKYVLTAPQPGKVAFLgIVQEKEFLNAGQEVLYINPGStDFFGEIHIPQYKMGKVYKDQ 344
Cdd:COG1566  193 QAEAALAQAELNL--------ARTTIRAPVDGVVTNL-NVEPGEVVSAGQPLLTIVPLD-DLWVEAYVPETDLGRVKPGQ 262
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255343456 345 EVLIKLKSYPFEEYgiiRGNIQSIADIPYKDS-----------VFVSRVSISNKGmsglkrNIRLKNGMIADAEIITE 411
Cdd:COG1566  263 PVEVRVDAYPDRVF---EGKVTSISPGAGFTSppknatgnvvqRYPVRIRLDNPD------PEPLRPGMSATVEIDTE 331
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
289-401 1.47e-12

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 63.54  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456  289 VLTAPQPGKVAFLGiVQEKEFLNAGQEVLYINPGSTdFFGEIHIPQYKMGKVYKDQEVLIKLKSYPfeEYgIIRGNIQSI 368
Cdd:pfam13437   1 TIRAPVDGVVAELN-VEEGQVVQAGDPLATIVPPDR-LLVEAFVPAADLGSLKKGQKVTLKLDPGS--DY-TLEGKVVRI 75
                          90       100       110
                  ....*....|....*....|....*....|....
gi 255343456  369 ADIPYKD-SVFVSRVSISNKGMSglkrnIRLKNG 401
Cdd:pfam13437  76 SPTVDPDtGVIPVRVSIENPKTP-----IPLLPG 104
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
61-400 1.72e-11

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 64.75  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456   61 ITSANApKSVISKISGQLVKVTVQENQAVITDQPLAYIESTASHEQVLQLLDELKNLQANlsegmiplkllatpknvflg 140
Cdd:pfam00529  15 VVSGNA-KAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQ-------------------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456  141 elqnayQSFYQSFLMYQSSIANgfylkKKVFLQKDLLSILDQKEQLLVQQKLQEKDYELGKKEFEMHQKLFEQKV---EA 217
Cdd:pfam00529  74 ------VARLQAELDRLQALES-----ELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGisrES 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456  218 PMELKREeskfiakRYPLQQT-ESALLSNSIIYSAKEKEIMELENLISEEKLKF---IQALNNFISNIEDWKKKYVLTAP 293
Cdd:pfam00529 143 LVTAGAL-------VAQAQANlLATVAQLDQIYVQITQSAAENQAEVRSELSGAqlqIAEAEAELKLAKLDLERTEIRAP 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255343456  294 QPGKVAFLGIVQEKEFLNAGQEVLYINPgSTDFFGEIHIPQYKMGKVYKDQEVLIKLKSYPFEEYGIIRGNIQSIADIPY 373
Cdd:pfam00529 216 VDGTVAFLSVTVDGGTVSAGLRLMFVVP-EDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTG 294
                         330       340
                  ....*....|....*....|....*...
gi 255343456  374 KDSVFVSRVSISNKGM-SGLKRNIRLKN 400
Cdd:pfam00529 295 PVRVVVDKAQGPYYPLrIGLSAGALVRL 322
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
70-123 4.96e-04

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 41.85  E-value: 4.96e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 255343456  70 VISKISGQLVKVTVQENQAVITDQPLAYIESTASHEQVLQLLDELKNLQANLSE 123
Cdd:COG0845   26 VRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLEL 79
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
72-110 6.20e-04

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 37.42  E-value: 6.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 255343456   72 SKISGQLVKVTVQENQAVITDQPLAYIESTASHEQVLQL 110
Cdd:pfam13533   7 SPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQA 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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