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Conserved domains on  [gi|224813804|gb|ACN65119|]
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arginine N-methyltransferase 1 [Schistosoma japonicum]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
45-210 1.59e-42

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 143.25  E-value: 1.59e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  45 HEEMLKDEIRTLTYRSALihnKRLVK-DKVVLDVGCGTAILCLFAIKAGAKHAIGIECS-NIIDRAVEVVRANNMPDRIT 122
Cdd:COG4076   12 HHPMLNDVERNDAFKAAI---ERVVKpGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRIT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804 123 LIKGKVEEVELPPefpKVDIVISEWMGYCLFYESMLNTVIYARDKWLAPGGIIMPDRATLYVCAIEDRQYKDEKINWwdS 202
Cdd:COG4076   89 VINADATDLDLPE---KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--Q 163


                 ....*...
gi 224813804 203 VYGFDMSC 210
Cdd:COG4076  164 FDGFDFRL 171
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
45-210 1.59e-42

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 143.25  E-value: 1.59e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  45 HEEMLKDEIRTLTYRSALihnKRLVK-DKVVLDVGCGTAILCLFAIKAGAKHAIGIECS-NIIDRAVEVVRANNMPDRIT 122
Cdd:COG4076   12 HHPMLNDVERNDAFKAAI---ERVVKpGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRIT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804 123 LIKGKVEEVELPPefpKVDIVISEWMGYCLFYESMLNTVIYARDKWLAPGGIIMPDRATLYVCAIEDRQYKDEKINWwdS 202
Cdd:COG4076   89 VINADATDLDLPE---KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--Q 163


                 ....*...
gi 224813804 203 VYGFDMSC 210
Cdd:COG4076  164 FDGFDFRL 171
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 74-176 3.04e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 3.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  74 VLDVGCGTAILCLFAIKAGAKHAIGIECS-NIIDRAVEVVRANNmPDRITLIKGKVEEVeLPPEFPKVDIVISeWMGYCL 152
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISpVALELARKAAAALL-ADNVEVLKGDAEEL-PPEADESFDVIIS-DPPLHH 78

                         90       100
                 ....*....|....*....|....
gi 224813804 153 FYESMLNTVIYARDKwLAPGGIIM 176
Cdd:cd02440   79 LVEDLARFLEEARRL-LKPGGVLV 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 74-173 3.00e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 55.26  E-value: 3.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804   74 VLDVGCGTAILCLFAIKAGAKHAIGIECS-NIIDRAVEVVRANNMpdRITLIKGKVEEVELPPEfpKVDIVISeWMGYCL 152
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSpEMLERARERAAEAGL--NVEFVQGDAEDLPFPDG--SFDLVVS-SGVLHH 75

                          90       100
                  ....*....|....*....|...
gi 224813804  153 FYESMLNTVI--YARdkWLAPGG 173
Cdd:pfam13649  76 LPDPDLEAALreIAR--VLKPGG 96
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
66-144 1.23e-09

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 56.31  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  66 KRLVKDKVVLDVGCGTAILCLFAIKAGAKHAIGIEcsniID-RAVEVVRAN---NmpdritlikGKVEEVELPPEFPKVD 141
Cdd:PRK00517 115 KLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD----IDpQAVEAARENaelN---------GVELNVYLPQGDLKAD 181


                 ...
gi 224813804 142 IVI 144
Cdd:PRK00517 182 VIV 184
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
45-210 1.59e-42

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 143.25  E-value: 1.59e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  45 HEEMLKDEIRTLTYRSALihnKRLVK-DKVVLDVGCGTAILCLFAIKAGAKHAIGIECS-NIIDRAVEVVRANNMPDRIT 122
Cdd:COG4076   12 HHPMLNDVERNDAFKAAI---ERVVKpGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRIT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804 123 LIKGKVEEVELPPefpKVDIVISEWMGYCLFYESMLNTVIYARDKWLAPGGIIMPDRATLYVCAIEDRQYKDEKINWwdS 202
Cdd:COG4076   89 VINADATDLDLPE---KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--Q 163


                 ....*...
gi 224813804 203 VYGFDMSC 210
Cdd:COG4076  164 FDGFDFRL 171
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
66-144 4.23e-13

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 66.35  E-value: 4.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  66 KRLVKDKVVLDVGCGTAILCLFAIKAGAKHAIGIEcsniIDR-AVEV----VRANNMPDRITLIKGKVEEVElppefpKV 140
Cdd:COG2264  144 KLLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVD----IDPvAVEAarenAELNGVEDRIEVVLGDLLEDG------PY 213


                 ....
gi 224813804 141 DIVI 144
Cdd:COG2264  214 DLVV 217
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 74-176 3.04e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 3.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  74 VLDVGCGTAILCLFAIKAGAKHAIGIECS-NIIDRAVEVVRANNmPDRITLIKGKVEEVeLPPEFPKVDIVISeWMGYCL 152
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISpVALELARKAAAALL-ADNVEVLKGDAEEL-PPEADESFDVIIS-DPPLHH 78

                         90       100
                 ....*....|....*....|....
gi 224813804 153 FYESMLNTVIYARDKwLAPGGIIM 176
Cdd:cd02440   79 LVEDLARFLEEARRL-LKPGGVLV 101
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 65-175 1.74e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 56.56  E-value: 1.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  65 NKRLVKDKVVLDVGCGTAILCLFAIKAGAkHAIGIEcsnIIDRAVEVVRANNMPDRITLIKGKVEEVELPPEfpKVDIVI 144
Cdd:COG2227   19 ARLLPAGGRVLDVGCGTGRLALALARRGA-DVTGVD---ISPEALEIARERAAELNVDFVQGDLEDLPLEDG--SFDLVI 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 224813804 145 SewmgyclfyesmLNTVIYARD---------KWLAPGGII 175
Cdd:COG2227   93 C------------SEVLEHLPDpaallrelaRLLKPGGLL 120
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
69-145 1.97e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 57.99  E-value: 1.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  69 VKDKVVLDVGCGTAILCLFAIKAGAKHAIGIEcsniID-RAVEVVRAN--NMPDRITLIKGKVEEVELPPEFpkvDIVIS 145
Cdd:COG2263   44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVD----IDpEALEIARENaeRLGVRVDFIRADVTRIPLGGSV---DTVVM 116
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 74-173 3.00e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 55.26  E-value: 3.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804   74 VLDVGCGTAILCLFAIKAGAKHAIGIECS-NIIDRAVEVVRANNMpdRITLIKGKVEEVELPPEfpKVDIVISeWMGYCL 152
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSpEMLERARERAAEAGL--NVEFVQGDAEDLPFPDG--SFDLVVS-SGVLHH 75

                          90       100
                  ....*....|....*....|...
gi 224813804  153 FYESMLNTVI--YARdkWLAPGG 173
Cdd:pfam13649  76 LPDPDLEAALreIAR--VLKPGG 96
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
66-144 1.23e-09

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 56.31  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  66 KRLVKDKVVLDVGCGTAILCLFAIKAGAKHAIGIEcsniID-RAVEVVRAN---NmpdritlikGKVEEVELPPEFPKVD 141
Cdd:PRK00517 115 KLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD----IDpQAVEAARENaelN---------GVELNVYLPQGDLKAD 181


                 ...
gi 224813804 142 IVI 144
Cdd:PRK00517 182 VIV 184
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 74-176 8.55e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 49.93  E-value: 8.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  74 VLDVGCGTAILCLFAIKAGAKHAIGIECS-NIIDRAVEVVRANNMPDRITLIKGKVEEVELPPEFpkvDIVIS----EWM 148
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGVRVTGVTLSpEQLEYARERAAEAGLADRVEVRLADYRDLPADGQF---DAIVSigmfEHV 131

                         90       100
                 ....*....|....*....|....*...
gi 224813804 149 GYcLFYESMLNTViyarDKWLAPGGIIM 176
Cdd:COG2230  132 GP-ENYPAYFAKV----ARLLKPGGRLL 154
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 59-145 3.66e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 3.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  59 RSALIHNKRLVKDKVVLDVGCGTAILCLFAIKAGAkHAIGIECS-NIIDRAVEvvRANNMPDRITLIKGKVEEVELPPEF 137
Cdd:COG2226   11 REALLAALGLRPGARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARE--RAAEAGLNVEFVVGDAEDLPFPDGS 87


                 ....*...
gi 224813804 138 pkVDIVIS 145
Cdd:COG2226   88 --FDLVIS 93
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 74-145 7.28e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 48.22  E-value: 7.28e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224813804  74 VLDVGCGTAILCLF-AIKAGAKHAIGIEC-SNIIDRAVEVVRANNMPDRITLIKGKVEEVELPPEFPKVDIVIS 145
Cdd:COG4123   41 VLDLGTGTGVIALMlAQRSPGARITGVEIqPEAAELARRNVALNGLEDRITVIHGDLKEFAAELPPGSFDLVVS 114
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 67-144 7.34e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 48.42  E-value: 7.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804   67 RLVK-DKVVLDVGCGTAILCLFAIKAGAKHAIGIEcsnIIDRAVEVVRA----NNMPDRItlikgkveEVELPPEFP--K 139
Cdd:pfam06325 157 RLVKpGESVLDVGCGSGILAIAALKLGAKKVVGVD---IDPVAVRAAKEnaelNGVEARL--------EVYLPGDLPkeK 225


                  ....*
gi 224813804  140 VDIVI 144
Cdd:pfam06325 226 ADVVV 230
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
29-176 1.34e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 46.92  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  29 MTSKDY---YFDSYAHfgIHEEMLKDEIRTLT---YRSALIHNKRLVKDKVVLDVGCGTAiLCLFAIKAGAKHAIGIECS 102
Cdd:COG4976    1 MALDAYveaLFDQYAD--SYDAALVEDLGYEApalLAEELLARLPPGPFGRVLDLGCGTG-LLGEALRPRGYRLTGVDLS 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224813804 103 niiDRAVEVVRANNMPDRitLIKGKVEEVELPPEfpKVDIVISeWMGYClfYESMLNTVIYARDKWLAPGGIIM 176
Cdd:COG4976   78 ---EEMLAKAREKGVYDR--LLVADLADLAEPDG--RFDLIVA-ADVLT--YLGDLAAVFAGVARALKPGGLFI 141
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-175 8.92e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 43.04  E-value: 8.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804   75 LDVGCGTAILCLFAIKAGAkHAIGIEcsnIIDRAVEVVRANNMPDRITLIKGKVEEVELPPEFpkVDIVISEWMgycLFY 154
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVD---ISPEMLELAREKAPREGLTFVVGDAEDLPFPDNS--FDLVLSSEV---LHH 71

                          90       100
                  ....*....|....*....|.
gi 224813804  155 ESMLNTVIYARDKWLAPGGII 175
Cdd:pfam08241  72 VEDPERALREIARVLKPGGIL 92
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 69-182 1.05e-05

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 44.88  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  69 VKDKVVLDVGCGTAILCLFAIKAGAKHaigIECSNIIDRAVEVVRANNMPDRITlIKGKVEEVELPPEFPKVDIVI-SEw 147
Cdd:COG3897   69 VAGKRVLELGCGLGLVGIAAAKAGAAD---VTATDYDPEALAALRLNAALNGVA-ITTRLGDWRDPPAAGGFDLILgGD- 143

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 224813804 148 mgycLFYESMLNTVIYAR-DKWLAPGGIIM---PDRATL 182
Cdd:COG3897  144 ----VLYERDLAEPLLPFlDRLAAPGGEVLigdPGRGYL 178
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 37-144 1.72e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 44.77  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  37 DSYAHFGIHeeMLKDEIRTLTYrSALihnkRLVKDKVVLDVGCGT---AILCLFAIKAGakHAIGIECSniiDRAVEVVR 113
Cdd:COG2242  221 EAFERDKGP--ITKREVRALTL-AKL----ALRPGDVLWDIGAGSgsvSIEAARLAPGG--RVYAIERD---PERAALIR 288

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 224813804 114 AN----NMPDrITLIKGKVEEVelPPEFPKVDIVI 144
Cdd:COG2242  289 ANarrfGVPN-VEVVEGEAPEA--LADLPDPDAVF 320
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 66-176 3.39e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.98  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  66 KRLVKDKVVLDVGCGTAILCLFAIKAGAKHAIGIECSNI-IDRAVEVVRANNmPDRITLIKGKVEEVElPPEFPKVDIVI 144
Cdd:COG0500   22 ERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEaIALARARAAKAG-LGNVEFLVADLAELD-PLPAESFDLVV 99

                         90       100       110
                 ....*....|....*....|....*....|....
gi 224813804 145 SEwmgYCLFYESMLNTVIYARD--KWLAPGGIIM 176
Cdd:COG0500  100 AF---GVLHHLPPEEREALLRElaRALKPGGVLL 130
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 68-145 8.36e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 41.25  E-value: 8.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804   68 LVKDKVVLDVGCGTAILCLFAIK--AGAKHAIGIEcsnIIDRAVEVVRAN---NMPDRITLIKGKVEEVELPPEFPKVDI 142
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGID---ISEEAIEKARENaqkLGFDNVEFEQGDIEELPELLEDDKFDV 77


                  ...
gi 224813804  143 VIS 145
Cdd:pfam13847  78 VIS 80
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
74-176 1.06e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 40.19  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  74 VLDVGCGT-AILCLFAIKAGAKHAIGIECSniiDRAVEVVRANNmpDRITLIKGKVEEVELPPEFpkvDIVISewmGYCL 152
Cdd:COG4106    5 VLDLGCGTgRLTALLAERFPGARVTGVDLS---PEMLARARARL--PNVRFVVADLRDLDPPEPF---DLVVS---NAAL 73

                         90       100
                 ....*....|....*....|....*...
gi 224813804 153 FY----ESMLNTVIyardKWLAPGGIIM 176
Cdd:COG4106   74 HWlpdhAALLARLA----AALAPGGVLA 97
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 48-182 1.38e-04

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 41.32  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  48 MLKDEIRTLTYRSAlihnkRLVKDKVVLDVGCGTAilclfAIKAGAKHAIGiECSNI--IDR---AVEVVRAN----NMP 118
Cdd:PRK00377  23 MTKEEIRALALSKL-----RLRKGDMILDIGCGTG-----SVTVEASLLVG-ETGKVyaVDKdekAINLTRRNaekfGVL 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224813804 119 DRITLIKGKVEEVeLPPEFPKVDIVISEWMGyclfyeSMLNTVIYARDKWLAPGGIIMPDRATL 182
Cdd:PRK00377  92 NNIVLIKGEAPEI-LFTINEKFDRIFIGGGS------EKLKEIISASWEIIKKGGRIVIDAILL 148
PRK14968 PRK14968
putative methyltransferase; Provisional
 62-176 3.41e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 39.88  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  62 LIHNKRLVKDKVVLDVGCGTAILCLFAIKAGAK--------HAI-----GIECSNIIDRAVEVVRAnnmpDRITLIKGKV 128
Cdd:PRK14968  15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKvvgvdinpYAVecakcNAKLNNIRNNGVEVIRS----DLFEPFRGDK 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 224813804 129 EEVEL--PPEFP-KVDIVISEWMGYCL--------FYESMLNTViyarDKWLAPGGIIM 176
Cdd:PRK14968  91 FDVILfnPPYLPtEEEEEWDDWLNYALsggkdgreVIDRFLDEV----GRYLKPGGRIL 145
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 63-145 4.11e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 40.15  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  63 IHNKRLVKDKVVLDVGCGTAILCLfAIKAGAKHAIGIeCSNIIDRAVEVVRAN---NMPDRITLIKGKVEEvelPPEFPK 139
Cdd:PRK09328 101 LEALLLKEPLRVLDLGTGSGAIAL-ALAKERPDAEVT-AVDISPEALAVARRNakhGLGARVEFLQGDWFE---PLPGGR 175


                 ....*.
gi 224813804 140 VDIVIS 145
Cdd:PRK09328 176 FDLIVS 181
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 73-145 7.01e-04

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 39.75  E-value: 7.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804  73 VVLDVGCGTAILCLfAIKAGAKHA--IGIECSniiDRAVEVVRAN----NMPDRITLIKGKV-EEVelpPEFPKVDIVIS 145
Cdd:COG2890  115 RVLDLGTGSGAIAL-ALAKERPDArvTAVDIS---PDALAVARRNaerlGLEDRVRFLQGDLfEPL---PGDGRFDLIVS 187
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 70-173 2.25e-03

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 38.15  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804   70 KDKVVLDVGCGTAILCLFAIKAGAKHAIGIECSNIIDRAVEVVRANNMPD-RITLIKGKVEEVelpPEFPKVDIVISewM 148
Cdd:pfam08003 115 KGRTILDVGCGNGYHMWRMLGEGAAMVVGIDPSELFLCQFEAVRKLLGNDqRAHLLPLGIEQL---PALAAFDTVFS--M 189

                          90       100
                  ....*....|....*....|....*
gi 224813804  149 GYCLFYESMLNTVIYARDKwLAPGG 173
Cdd:pfam08003 190 GVLYHRRSPLDHLLQLKDQ-LVKGG 213
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
68-140 2.59e-03

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 37.96  E-value: 2.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224813804  68 LVKDKVVLDVGCGTAILCLFaIKAGAKHAIGIEcsniIDRAVEVVRANNMPD--RITLIKGKVEEVELpPEFPKV 140
Cdd:PRK14896  27 DTDGDPVLEIGPGKGALTDE-LAKRAKKVYAIE----LDPRLAEFLRDDEIAagNVEIIEGDALKVDL-PEFNKV 95
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
69-200 2.98e-03

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 37.22  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224813804   69 VKDKVVLDVGCGTAILCLFAIKAGAKHAIGIECSniiDRAVEVVRAN----NMPDRiTLIKGKVEEVE-LPPEFPKVDIV 143
Cdd:pfam03602  40 IEGARVLDLFAGSGALGLEALSRGAKRVTLVEKD---KRAVQILKENlqllGLPGA-VLVMDALLALLrLAGKGPVFDIV 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224813804  144 IsewmgycL---FYESMLNTVI--YARDKWLAPGGIImpdratlyVCAIEDRQYKDEKINWW 200
Cdd:pfam03602 116 F-------LdppYAKGLIEEVLdlLAEKGWLKPNALI--------YVETEKRGELPEQPGNL 162
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 70-145 5.61e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.41  E-value: 5.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224813804   70 KDKVVLDVGCGTAILCLFAIKAGAKHAigIECSNIIDRAVEVVRAN---NMPDRITLIKGKVEEvELPPEfpKVDIVIS 145
Cdd:pfam05175  31 LSGKVLDLGCGAGVLGAALAKESPDAE--LTMVDINARALESARENlaaNGLENGEVVASDVYS-GVEDG--KFDLIIS 104
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
70-100 6.34e-03

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 36.76  E-value: 6.34e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 224813804  70 KDKVVLDVGCGTAILCLFAIKAGAKHAIGIE 100
Cdd:PRK15068 122 KGRTVLDVGCGNGYHMWRMLGAGAKLVVGID 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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