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Conserved domains on  [gi|221564986|gb|ACM20958|]
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proline dehydrogenase and Delta-1-pyrroline-5-carboxylate dehydrogenase [Geotalea daltonii FRC-32]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ALDH_PutA-P5CDH-RocA cd07124
Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Delta(1)-pyrroline-5-carboxylate ...
476-985 0e+00

Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), RocA: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. The proline catabolic enzymes, proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), catalyze the two-step oxidation of proline to glutamate; P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA). In this CD, monofunctional enzyme sequences such as seen in the Bacillus subtilis RocA P5CDH are also present. These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis.


:

Pssm-ID: 143442  Cd Length: 512  Bit Score: 803.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  476 FSNEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARK 555
Cdd:cd07124     1 FRNEPFTDFADEENRAAFRAALARVREELGREYPLVIGGKEVRTEEKIESRNPADPSEVLGTVQKATKEEAEAAVQAARA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  556 SFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRL-GSPRSMgkVAGE 634
Cdd:cd07124    81 AFPTWRRTPPEERARLLLRAAALLRRRRFELAAWMVLEVGKNWAEADADVAEAIDFLEYYAREMLRLrGFPVEM--VPGE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  635 TNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGD 714
Cdd:cd07124   159 DNRYVYRPLGVGAVISPWNFPLAILAGMTTAALVTGNTVVLKPAEDTPVIAAKLVEILEEAGLPPGVVNFLPGPGEEVGD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  715 YLVDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSAC 794
Cdd:cd07124   239 YLVEHPDVRFIAFTGSREVGLRIYERAAKVQPGQKWLKRVIAEMGGKNAIIVDEDADLDEAAEGIVRSAFGFQGQKCSAC 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  795 SRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEV---GFFVPLT 871
Cdd:cd07124   319 SRVIVHESVYDEFLERLVERTKALKVGDPEDPEVYMGPVIDKGARDRIRRYIEIGKSEGRLLLGGEVLELaaeGYFVQPT 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  872 IIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGR 951
Cdd:cd07124   399 IFADVPPDHRLAQEEIFGPVLAVIKAKDFDEALEIANDTEYGLTGGVFSRSPEHLERARREFEVGNLYANRKITGALVGR 478
                         490       500       510
                  ....*....|....*....|....*....|....
gi 221564986  952 QPFGGFRLSGAGTKAGGPDYLLHFMDPRVVTENT 985
Cdd:cd07124   479 QPFGGFKMSGTGSKAGGPDYLLQFMQPKTVTENF 512
Pro_dh pfam01619
Proline dehydrogenase;
126-433 8.87e-113

Proline dehydrogenase;


:

Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 349.87  E-value: 8.87e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   126 AISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIERAMGRWKPlgagrtsgsmdwghAPRINVSVKATAL 205
Cdd:pfam01619    1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALGKAAGPWPL--------------GPRPGISVKLSAL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   206 SCLASPMDYEGSVAAILRRLRLICRRVREVNGFLCLDMETYRYKEIILEVYRRL--KLENPDYHHLGLVLQSYLRDTDHD 283
Cdd:pfam01619   67 HPRYEPLERERVMAELLERLRPLCRLAKELGVRLNIDAEEADRLDLTLDLFERLlaEPELRGWNGVGITLQAYLKDALAV 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   284 LDNLVTWARENCLGISIRLVKGAYWDYEMIRSRQSGLPEPVWTMKAETDAAFERQARRIMENSDVCHFACASHNIRSISA 363
Cdd:pfam01619  147 LDWLLELARRRGRPLGVRLVKGAYWDSEIKRAQQGGWPYPVFTRKEATDANYEACARFLLENHDRIYPQFATHNARSVAA 226
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   364 VIELARELAVSDDRYEFQVLYGMAEPVRKAILNRTGRLRLYCPYGPMVPGMGYLVRRLLENTSNVSFLRQ 433
Cdd:pfam01619  227 ALALAEELGIPPRRFEFQQLYGMGDNLSFALVAAGYRVRKYAPVGPHEELLAYLVRRLLENTANSSFVRR 296
PutA_N pfam18083
Proline utilization A N-terminal domain; This domain is found in Proline utilization A (PutA) ...
8-117 9.91e-30

Proline utilization A N-terminal domain; This domain is found in Proline utilization A (PutA) proteins present in Geobacter sulfurreducens. PutA are bifunctional peripheral membrane flavoenzymes that catalyze the oxidation of l-proline to l-glutamate and couple the oxidation of imported proline imported to the reduction of membrane-associated quinones. This domain is located at the N-terminus and is referred to as the alpha domain. The hydrocarbon tail of Zwittergent 3-12 binds to an exposed hydrophobic patch of the alpha domain which contains aromatic and nonpolar residues. The domain may be involved in membrane association.


:

Pssm-ID: 436258  Cd Length: 113  Bit Score: 113.99  E-value: 9.91e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986     8 RRIVSCGREMFAGIYGETPSLFDKGRWLGKLMAWSMSDEEFKTRLFRFVDVFPTLSTDRMVADHLEEYFDGAQPPVLALL 87
Cdd:pfam18083    2 ARTQRIGRELFAALSGERPSLFDRRWWDDKLMEWAMKDEQLKVQLFRFVDVLPALKTPAEVARHLREYLGDVQDELPQPL 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 221564986    88 RQAAGVFGpfGNFIQRKAVSTAIRK----MAQQF 117
Cdd:pfam18083   82 RWALRAAD--GGSLGGRALAKAARKgaeqMARRF 113
 
Name Accession Description Interval E-value
ALDH_PutA-P5CDH-RocA cd07124
Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Delta(1)-pyrroline-5-carboxylate ...
476-985 0e+00

Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), RocA: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. The proline catabolic enzymes, proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), catalyze the two-step oxidation of proline to glutamate; P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA). In this CD, monofunctional enzyme sequences such as seen in the Bacillus subtilis RocA P5CDH are also present. These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis.


Pssm-ID: 143442  Cd Length: 512  Bit Score: 803.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  476 FSNEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARK 555
Cdd:cd07124     1 FRNEPFTDFADEENRAAFRAALARVREELGREYPLVIGGKEVRTEEKIESRNPADPSEVLGTVQKATKEEAEAAVQAARA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  556 SFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRL-GSPRSMgkVAGE 634
Cdd:cd07124    81 AFPTWRRTPPEERARLLLRAAALLRRRRFELAAWMVLEVGKNWAEADADVAEAIDFLEYYAREMLRLrGFPVEM--VPGE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  635 TNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGD 714
Cdd:cd07124   159 DNRYVYRPLGVGAVISPWNFPLAILAGMTTAALVTGNTVVLKPAEDTPVIAAKLVEILEEAGLPPGVVNFLPGPGEEVGD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  715 YLVDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSAC 794
Cdd:cd07124   239 YLVEHPDVRFIAFTGSREVGLRIYERAAKVQPGQKWLKRVIAEMGGKNAIIVDEDADLDEAAEGIVRSAFGFQGQKCSAC 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  795 SRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEV---GFFVPLT 871
Cdd:cd07124   319 SRVIVHESVYDEFLERLVERTKALKVGDPEDPEVYMGPVIDKGARDRIRRYIEIGKSEGRLLLGGEVLELaaeGYFVQPT 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  872 IIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGR 951
Cdd:cd07124   399 IFADVPPDHRLAQEEIFGPVLAVIKAKDFDEALEIANDTEYGLTGGVFSRSPEHLERARREFEVGNLYANRKITGALVGR 478
                         490       500       510
                  ....*....|....*....|....*....|....
gi 221564986  952 QPFGGFRLSGAGTKAGGPDYLLHFMDPRVVTENT 985
Cdd:cd07124   479 QPFGGFKMSGTGSKAGGPDYLLQFMQPKTVTENF 512
PRK03137 PRK03137
1-pyrroline-5-carboxylate dehydrogenase; Provisional
472-983 0e+00

1-pyrroline-5-carboxylate dehydrogenase; Provisional


Pssm-ID: 179543  Cd Length: 514  Bit Score: 712.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  472 KVIPFSNEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIG 551
Cdd:PRK03137    1 MVVPYKHEPFTDFSVEENVEAFEEALKKVEKELGQDYPLIIGGERITTEDKIVSINPANKSEVVGRVSKATKELAEKAMQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  552 AARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKV 631
Cdd:PRK03137   81 AALEAFETWKKWSPEDRARILLRAAAIIRRRKHEFSAWLVKEAGKPWAEADADTAEAIDFLEYYARQMLKLADGKPVESR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  632 AGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGI 711
Cdd:PRK03137  161 PGEHNRYFYIPLGVGVVISPWNFPFAIMAGMTLAAIVAGNTVLLKPASDTPVIAAKFVEVLEEAGLPAGVVNFVPGSGSE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  712 MGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKC 791
Cdd:PRK03137  241 VGDYLVDHPKTRFITFTGSREVGLRIYERAAKVQPGQIWLKRVIAEMGGKDAIVVDEDADLDLAAESIVASAFGFSGQKC 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  792 SACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLiGAVAEENAQKRIMNYIEVGRQEGRLLYQGHV-PEVGFFVPL 870
Cdd:PRK03137  321 SACSRAIVHEDVYDEVLEKVVELTKELTVGNPEDNAYM-GPVINQASFDKIMSYIEIGKEEGRLVLGGEGdDSKGYFIQP 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  871 TIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVG 950
Cdd:PRK03137  400 TIFADVDPKARIMQEEIFGPVVAFIKAKDFDHALEIANNTEYGLTGAVISNNREHLEKARREFHVGNLYFNRGCTGAIVG 479
                         490       500       510
                  ....*....|....*....|....*....|...
gi 221564986  951 RQPFGGFRLSGAGTKAGGPDYLLHFMDPRVVTE 983
Cdd:PRK03137  480 YHPFGGFNMSGTDSKAGGPDYLLLFLQAKTVSE 512
D1pyr5carbox2 TIGR01237
delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; This enzyme is the second of ...
476-984 0e+00

delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; This enzyme is the second of two in the degradation of proline to glutamate. This model represents one of several related branches of delta-1-pyrroline-5-carboxylate dehydrogenase. Members of this branch may be associated with proline dehydrogenase (the other enzyme of the pathway from proline to glutamate) but have not been demonstrated experimentally. The branches are not as closely related to each other as some distinct aldehyde dehydrogenases are to some; separate models were built to let each model describe a set of equivalogs. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200087 [Multi-domain]  Cd Length: 511  Bit Score: 636.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   476 FSNEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARK 555
Cdd:TIGR01237    1 YKHEPFTDFADEENRQAFFKALATVKEQLGKTYPLVINGERVETENKIVSINPCDKSEVVGTVSKASQEHAEHALQAAAK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   556 SFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKVAGET 635
Cdd:TIGR01237   81 AFEAWKKTDPEERAAILFKAAAIVRRRRHEFSALLVKEVGKPWNEADAEVAEAIDFMEYYARQMIELAKGKPVNSREGET 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   636 NQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDY 715
Cdd:TIGR01237  161 NQYVYTPTGVTVVISPWNFPFAIMVGMTVAPIVTGNCVVLKPAEAAPVIAAKFVEILEEAGLPKGVVQFVPGSGSEVGDY 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   716 LVDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACS 795
Cdd:TIGR01237  241 LVDHPKTSLITFTGSREVGTRIFERAAKVQPGQKHLKRVIAEMGGKDTVIVDEDADIELAAQSAFTSAFGFAGQKCSAGS 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   796 RVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGH-VPEVGFFVPLTIIG 874
Cdd:TIGR01237  321 RAVVHEKVYDEVVERFVEITESLKVGPPDSADVYVGPVIDQKSFNKIMEYIEIGKAEGRLVSGGCgDDSKGYFIGPTIFA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   875 DIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQPF 954
Cdd:TIGR01237  401 DVDRKARLAQEEIFGPVVAFIRASDFDEALEIANNTEYGLTGGVISNNRDHINRAKAEFEVGNLYFNRNITGAIVGYQPF 480
                          490       500       510
                   ....*....|....*....|....*....|
gi 221564986   955 GGFRLSGAGTKAGGPDYLLHFMDPRVVTEN 984
Cdd:TIGR01237  481 GGFKMSGTDSKAGGPDYLALFMQAKTVTEM 510
AdhE COG1012
Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and ...
506-985 2.15e-167

Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and metabolism]; Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440636 [Multi-domain]  Cd Length: 479  Bit Score: 498.88  E-value: 2.15e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  506 RKYPLFIGGQELE--TEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRI 583
Cdd:COG1012     4 PEYPLFIGGEWVAaaSGETFDVINPAT-GEVLARVPAATAEDVDAAVAAARAAFPAWAATPPAERAAILLRAADLLEERR 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  584 YELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMV 663
Cdd:COG1012    83 EELAALLTLETGKPLAEARGEVDRAADFLRYYAGEARRLYGETIPSDAPGTRAYVRREPLGVVGAITPWNFPLALAAWKL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  664 SAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAk 743
Cdd:COG1012   163 APALAAGNTVVLKPAEQTPLSALLLAELLEEAGLPAGVLNVVTGDGSEVGAALVAHPDVDKISFTGSTAVGRRIAAAAA- 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  744 vqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPV 823
Cdd:COG1012   242 -----ENLKRVTLELGGKNPAIVLDDADLDAAVEAAVRGAFGNAGQRCTAASRLLVHESIYDEFVERLVAAAKALKVGDP 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  824 EDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV--GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDF 900
Cdd:COG1012   317 LDPGTDMGPLISEAQLERVLAYIEDAVAEGaELLTGGRRPDGegGYFVEPTVLADVTPDMRIAREEIFGPVLSVIPFDDE 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  901 NEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGAlVGRQPFGGFRLSGAGTKaGGPDYLLHFMDPRV 980
Cdd:COG1012   397 EEAIALANDTEYGLAASVFTRDLARARRVARRLEAGMVWINDGTTGA-VPQAPFGGVKQSGIGRE-GGREGLEEYTETKT 474

                  ....*
gi 221564986  981 VTENT 985
Cdd:COG1012   475 VTIRL 479
Aldedh pfam00171
Aldehyde dehydrogenase family; This family of dehydrogenases act on aldehyde substrates. ...
523-981 1.33e-153

Aldehyde dehydrogenase family; This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.


Pssm-ID: 425500 [Multi-domain]  Cd Length: 459  Bit Score: 462.39  E-value: 1.33e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   523 LPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAY 602
Cdd:pfam00171    9 IEVINPAT-GEVIATVPAATAEDVDAAIAAARAAFPAWRKTPAAERAAILRKAADLLEERKDELAELETLENGKPLAEAR 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   603 ADVTEAIDFLEYYAREMIRLgSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTS 682
Cdd:pfam00171   88 GEVDRAIDVLRYYAGLARRL-DGETLPSDPGRLAYTRREPLGVVGAITPWNFPLLLPAWKIAPALAAGNTVVLKPSELTP 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   683 IIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKN 762
Cdd:pfam00171  167 LTALLLAELFEEAGLPAGVLNVVTGSGAEVGEALVEHPDVRKVSFTGSTAVGRHIAEAAAQ------NLKRVTLELGGKN 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   763 AIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRI 842
Cdd:pfam00171  241 PLIVLEDADLDAAVEAAVFGAFGNAGQVCTATSRLLVHESIYDEFVEKLVEAAKKLKVGDPLDPDTDMGPLISKAQLERV 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   843 MNYIEVGRQEG-RLLYQGH-VPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFS 920
Cdd:pfam00171  321 LKYVEDAKEEGaKLLTGGEaGLDNGYFVEPTVLANVTPDMRIAQEEIFGPVLSVIRFKDEEEAIEIANDTEYGLAAGVFT 400
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221564986   921 RSPEHIAIATKRFRVGNLYLNRNCTGALVGRqPFGGFRLSGAGtKAGGPDYLLHFMDPRVV 981
Cdd:pfam00171  401 SDLERALRVARRLEAGMVWINDYTTGDADGL-PFGGFKQSGFG-REGGPYGLEEYTEVKTV 459
Pro_dh pfam01619
Proline dehydrogenase;
126-433 8.87e-113

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 349.87  E-value: 8.87e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   126 AISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIERAMGRWKPlgagrtsgsmdwghAPRINVSVKATAL 205
Cdd:pfam01619    1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALGKAAGPWPL--------------GPRPGISVKLSAL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   206 SCLASPMDYEGSVAAILRRLRLICRRVREVNGFLCLDMETYRYKEIILEVYRRL--KLENPDYHHLGLVLQSYLRDTDHD 283
Cdd:pfam01619   67 HPRYEPLERERVMAELLERLRPLCRLAKELGVRLNIDAEEADRLDLTLDLFERLlaEPELRGWNGVGITLQAYLKDALAV 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   284 LDNLVTWARENCLGISIRLVKGAYWDYEMIRSRQSGLPEPVWTMKAETDAAFERQARRIMENSDVCHFACASHNIRSISA 363
Cdd:pfam01619  147 LDWLLELARRRGRPLGVRLVKGAYWDSEIKRAQQGGWPYPVFTRKEATDANYEACARFLLENHDRIYPQFATHNARSVAA 226
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   364 VIELARELAVSDDRYEFQVLYGMAEPVRKAILNRTGRLRLYCPYGPMVPGMGYLVRRLLENTSNVSFLRQ 433
Cdd:pfam01619  227 ALALAEELGIPPRRFEFQQLYGMGDNLSFALVAAGYRVRKYAPVGPHEELLAYLVRRLLENTANSSFVRR 296
PutA_N pfam18083
Proline utilization A N-terminal domain; This domain is found in Proline utilization A (PutA) ...
8-117 9.91e-30

Proline utilization A N-terminal domain; This domain is found in Proline utilization A (PutA) proteins present in Geobacter sulfurreducens. PutA are bifunctional peripheral membrane flavoenzymes that catalyze the oxidation of l-proline to l-glutamate and couple the oxidation of imported proline imported to the reduction of membrane-associated quinones. This domain is located at the N-terminus and is referred to as the alpha domain. The hydrocarbon tail of Zwittergent 3-12 binds to an exposed hydrophobic patch of the alpha domain which contains aromatic and nonpolar residues. The domain may be involved in membrane association.


Pssm-ID: 436258  Cd Length: 113  Bit Score: 113.99  E-value: 9.91e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986     8 RRIVSCGREMFAGIYGETPSLFDKGRWLGKLMAWSMSDEEFKTRLFRFVDVFPTLSTDRMVADHLEEYFDGAQPPVLALL 87
Cdd:pfam18083    2 ARTQRIGRELFAALSGERPSLFDRRWWDDKLMEWAMKDEQLKVQLFRFVDVLPALKTPAEVARHLREYLGDVQDELPQPL 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 221564986    88 RQAAGVFGpfGNFIQRKAVSTAIRK----MAQQF 117
Cdd:pfam18083   82 RWALRAAD--GGSLGGRALAKAARKgaeqMARRF 113
PLN02681 PLN02681
proline dehydrogenase
103-424 9.17e-19

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 90.53  E-value: 9.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  103 RKAVSTAIRKMA-QQFIVGENTTEAISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIERAMGRWK---- 177
Cdd:PLN02681   73 RAIVLALVKATFySHFCAGEDAEEAARTVRRLWELGLGGILDYAAEDAGDNAACDRNLEKFLAAIRAAATLPPSSSsaav 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  178 ------PLG-AGRTSGSMDWGHA-PRINVSVKATA--LSCLASPM------------DYEGSVAAILRRLRLICRRVREV 235
Cdd:PLN02681  153 kitalcPPSlLERVSDLLRWQDRdPNGKLPWKQWSfpLFADSSPLyhatsepepltaEEERLLELAHERLQKLCERAAQL 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  236 NGFLCLDMETYRYKEIILEVYRRLKLE---NPDYHHLGLVLQSYLRDTDHDLDNLVTWARENCLGISIRLVKGAYWDYEM 312
Cdd:PLN02681  233 GVPLLIDAEYTSLQPAIDYITYDLAREfnkGKDRPIVYGTYQAYLKDARERLRLDLERSEREGVPLGAKLVRGAYLSLER 312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  313 IRSRQSGLPEPVWTMKAETDAAFERQARRIME---NSDvCHFACASHNIRSISAVIELARELAVS--DDRYEFQVLYGMA 387
Cdd:PLN02681  313 RLAASLGVPSPVHDTIQDTHACYNRCAEFLLEkasNGD-GEVMLATHNVESGELAAAKMNELGLHkgDPRVQFAQLLGMS 391
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 221564986  388 EPVRKAILNRTGRLRLYCPYGPMVPGMGYLVRRLLEN 424
Cdd:PLN02681  392 DNLSFGLGNAGFRVSKYLPYGPVEEVIPYLLRRAEEN 428
 
Name Accession Description Interval E-value
ALDH_PutA-P5CDH-RocA cd07124
Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Delta(1)-pyrroline-5-carboxylate ...
476-985 0e+00

Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), RocA: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. The proline catabolic enzymes, proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), catalyze the two-step oxidation of proline to glutamate; P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA). In this CD, monofunctional enzyme sequences such as seen in the Bacillus subtilis RocA P5CDH are also present. These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis.


Pssm-ID: 143442  Cd Length: 512  Bit Score: 803.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  476 FSNEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARK 555
Cdd:cd07124     1 FRNEPFTDFADEENRAAFRAALARVREELGREYPLVIGGKEVRTEEKIESRNPADPSEVLGTVQKATKEEAEAAVQAARA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  556 SFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRL-GSPRSMgkVAGE 634
Cdd:cd07124    81 AFPTWRRTPPEERARLLLRAAALLRRRRFELAAWMVLEVGKNWAEADADVAEAIDFLEYYAREMLRLrGFPVEM--VPGE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  635 TNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGD 714
Cdd:cd07124   159 DNRYVYRPLGVGAVISPWNFPLAILAGMTTAALVTGNTVVLKPAEDTPVIAAKLVEILEEAGLPPGVVNFLPGPGEEVGD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  715 YLVDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSAC 794
Cdd:cd07124   239 YLVEHPDVRFIAFTGSREVGLRIYERAAKVQPGQKWLKRVIAEMGGKNAIIVDEDADLDEAAEGIVRSAFGFQGQKCSAC 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  795 SRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEV---GFFVPLT 871
Cdd:cd07124   319 SRVIVHESVYDEFLERLVERTKALKVGDPEDPEVYMGPVIDKGARDRIRRYIEIGKSEGRLLLGGEVLELaaeGYFVQPT 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  872 IIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGR 951
Cdd:cd07124   399 IFADVPPDHRLAQEEIFGPVLAVIKAKDFDEALEIANDTEYGLTGGVFSRSPEHLERARREFEVGNLYANRKITGALVGR 478
                         490       500       510
                  ....*....|....*....|....*....|....
gi 221564986  952 QPFGGFRLSGAGTKAGGPDYLLHFMDPRVVTENT 985
Cdd:cd07124   479 QPFGGFKMSGTGSKAGGPDYLLQFMQPKTVTENF 512
PRK03137 PRK03137
1-pyrroline-5-carboxylate dehydrogenase; Provisional
472-983 0e+00

1-pyrroline-5-carboxylate dehydrogenase; Provisional


Pssm-ID: 179543  Cd Length: 514  Bit Score: 712.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  472 KVIPFSNEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIG 551
Cdd:PRK03137    1 MVVPYKHEPFTDFSVEENVEAFEEALKKVEKELGQDYPLIIGGERITTEDKIVSINPANKSEVVGRVSKATKELAEKAMQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  552 AARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKV 631
Cdd:PRK03137   81 AALEAFETWKKWSPEDRARILLRAAAIIRRRKHEFSAWLVKEAGKPWAEADADTAEAIDFLEYYARQMLKLADGKPVESR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  632 AGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGI 711
Cdd:PRK03137  161 PGEHNRYFYIPLGVGVVISPWNFPFAIMAGMTLAAIVAGNTVLLKPASDTPVIAAKFVEVLEEAGLPAGVVNFVPGSGSE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  712 MGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKC 791
Cdd:PRK03137  241 VGDYLVDHPKTRFITFTGSREVGLRIYERAAKVQPGQIWLKRVIAEMGGKDAIVVDEDADLDLAAESIVASAFGFSGQKC 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  792 SACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLiGAVAEENAQKRIMNYIEVGRQEGRLLYQGHV-PEVGFFVPL 870
Cdd:PRK03137  321 SACSRAIVHEDVYDEVLEKVVELTKELTVGNPEDNAYM-GPVINQASFDKIMSYIEIGKEEGRLVLGGEGdDSKGYFIQP 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  871 TIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVG 950
Cdd:PRK03137  400 TIFADVDPKARIMQEEIFGPVVAFIKAKDFDHALEIANNTEYGLTGAVISNNREHLEKARREFHVGNLYFNRGCTGAIVG 479
                         490       500       510
                  ....*....|....*....|....*....|...
gi 221564986  951 RQPFGGFRLSGAGTKAGGPDYLLHFMDPRVVTE 983
Cdd:PRK03137  480 YHPFGGFNMSGTDSKAGGPDYLLLFLQAKTVSE 512
D1pyr5carbox2 TIGR01237
delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; This enzyme is the second of ...
476-984 0e+00

delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; This enzyme is the second of two in the degradation of proline to glutamate. This model represents one of several related branches of delta-1-pyrroline-5-carboxylate dehydrogenase. Members of this branch may be associated with proline dehydrogenase (the other enzyme of the pathway from proline to glutamate) but have not been demonstrated experimentally. The branches are not as closely related to each other as some distinct aldehyde dehydrogenases are to some; separate models were built to let each model describe a set of equivalogs. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200087 [Multi-domain]  Cd Length: 511  Bit Score: 636.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   476 FSNEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARK 555
Cdd:TIGR01237    1 YKHEPFTDFADEENRQAFFKALATVKEQLGKTYPLVINGERVETENKIVSINPCDKSEVVGTVSKASQEHAEHALQAAAK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   556 SFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKVAGET 635
Cdd:TIGR01237   81 AFEAWKKTDPEERAAILFKAAAIVRRRRHEFSALLVKEVGKPWNEADAEVAEAIDFMEYYARQMIELAKGKPVNSREGET 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   636 NQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDY 715
Cdd:TIGR01237  161 NQYVYTPTGVTVVISPWNFPFAIMVGMTVAPIVTGNCVVLKPAEAAPVIAAKFVEILEEAGLPKGVVQFVPGSGSEVGDY 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   716 LVDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACS 795
Cdd:TIGR01237  241 LVDHPKTSLITFTGSREVGTRIFERAAKVQPGQKHLKRVIAEMGGKDTVIVDEDADIELAAQSAFTSAFGFAGQKCSAGS 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   796 RVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGH-VPEVGFFVPLTIIG 874
Cdd:TIGR01237  321 RAVVHEKVYDEVVERFVEITESLKVGPPDSADVYVGPVIDQKSFNKIMEYIEIGKAEGRLVSGGCgDDSKGYFIGPTIFA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   875 DIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQPF 954
Cdd:TIGR01237  401 DVDRKARLAQEEIFGPVVAFIRASDFDEALEIANNTEYGLTGGVISNNRDHINRAKAEFEVGNLYFNRNITGAIVGYQPF 480
                          490       500       510
                   ....*....|....*....|....*....|
gi 221564986   955 GGFRLSGAGTKAGGPDYLLHFMDPRVVTEN 984
Cdd:TIGR01237  481 GGFKMSGTDSKAGGPDYLALFMQAKTVTEM 510
PRK11904 PRK11904
bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;
103-985 1.06e-173

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;


Pssm-ID: 237017 [Multi-domain]  Cd Length: 1038  Bit Score: 534.39  E-value: 1.06e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  103 RKAVSTAIRKMAQQFIVGENTTEAISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIeramgrwkplgaG 182
Cdd:PRK11904  166 RKAMRQAMKIMGKQFVLGRTIEEALKRARSARNKGYRYSFDMLGEAALTAADAERYFKAYARAIEAI------------G 233
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  183 RTSGSMDWGHAPRInvSVKATALSclasPMdYEGS-----VAAILRRLRLICRRVREVNGFLCLDMETYRYKEIILEVYR 257
Cdd:PRK11904  234 RAAGGADLPARPGI--SIKLSALH----PR-YEAAqrervLAELVPRVLELARLAKEANIGLTIDAEEADRLELSLDLFE 306
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  258 RLKLEN--PDYHHLGLVLQSYLRDTDHDLDNLVTWARENCLGISIRLVKGAYWDYEMIRSRQSGLPE-PVWTMKAETDAA 334
Cdd:PRK11904  307 ALFRDPslKGWGGFGLAVQAYQKRALPVLDWLADLARRQGRRIPVRLVKGAYWDSEIKRAQELGLPGyPVFTRKAATDVS 386
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  335 FERQARRIMENSDVCHFACASHNIRSISAVIELArelavSDDRYEFQVLYGMAEPVRKAILNRTG-RLRLYCPYGP---M 410
Cdd:PRK11904  387 YLACARKLLSARGAIYPQFATHNAHTVAAILEMA-----GHRGFEFQRLHGMGEALYDALLDAPGiPCRIYAPVGShkdL 461
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  411 VPgmgYLVRRLLENTSNVSFLRQtFVDA-AGAEKLLEDPLHVVERQRLAVQPRlregakssgkvIPF---------SNEP 480
Cdd:PRK11904  462 LP---YLVRRLLENGANSSFVHR-LVDPdVPIEELVADPVEKLRSFETLPNPK-----------IPLprdifgperKNSK 526
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  481 VIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELEtedllPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARKSFETW 560
Cdd:PRK11904  527 GLNLNDRSELEPLAAAIAAFLEKQWQAGPIINGEGEAR-----PVVSPADRRRVVGEVAFADAEQVEQALAAARAAFPAW 601
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  561 RDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRL-GSPRSMGKVAGETNQYF 639
Cdd:PRK11904  602 SRTPVEERAAILERAADLLEANRAELIALCVREAGKTLQDAIAEVREAVDFCRYYAAQARRLfGAPEKLPGPTGESNELR 681
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  640 YEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDH 719
Cdd:PRK11904  682 LHGRGVFVCISPWNFPLAIFLGQVAAALAAGNTVIAKPAEQTPLIAAEAVKLLHEAGIPKDVLQLLPGDGATVGAALTAD 761
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  720 PHVSLIAFTGSMEVGlRIIER--AAKVQPgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACsRV 797
Cdd:PRK11904  762 PRIAGVAFTGSTETA-RIINRtlAARDGP----IVPLIAETGGQNAMIVDSTALPEQVVDDVVTSAFRSAGQRCSAL-RV 835
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  798 IVL-DGIYDKFVQRLTALAEAVPVGpveDPANL---IGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVP---EVGFFVPL 870
Cdd:PRK11904  836 LFVqEDIADRVIEMLKGAMAELKVG---DPRLLstdVGPVIDAEAKANLDAHIERMKREARLLAQLPLPagtENGHFVAP 912
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  871 TI--IGDIrpehRLAQEEIFGPLLAVMR--ARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTG 946
Cdd:PRK11904  913 TAfeIDSI----SQLEREVFGPILHVIRykASDLDKVIDAINATGYGLTLGIHSRIEETADRIADRVRVGNVYVNRNQIG 988
                         890       900       910
                  ....*....|....*....|....*....|....*....
gi 221564986  947 ALVGRQPFGGFRLSGAGTKAGGPDYLLHFMDPRVVTENT 985
Cdd:PRK11904  989 AVVGVQPFGGQGLSGTGPKAGGPHYLLRFATEKTVTVNT 1027
AdhE COG1012
Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and ...
506-985 2.15e-167

Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and metabolism]; Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440636 [Multi-domain]  Cd Length: 479  Bit Score: 498.88  E-value: 2.15e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  506 RKYPLFIGGQELE--TEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRI 583
Cdd:COG1012     4 PEYPLFIGGEWVAaaSGETFDVINPAT-GEVLARVPAATAEDVDAAVAAARAAFPAWAATPPAERAAILLRAADLLEERR 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  584 YELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMV 663
Cdd:COG1012    83 EELAALLTLETGKPLAEARGEVDRAADFLRYYAGEARRLYGETIPSDAPGTRAYVRREPLGVVGAITPWNFPLALAAWKL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  664 SAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAk 743
Cdd:COG1012   163 APALAAGNTVVLKPAEQTPLSALLLAELLEEAGLPAGVLNVVTGDGSEVGAALVAHPDVDKISFTGSTAVGRRIAAAAA- 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  744 vqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPV 823
Cdd:COG1012   242 -----ENLKRVTLELGGKNPAIVLDDADLDAAVEAAVRGAFGNAGQRCTAASRLLVHESIYDEFVERLVAAAKALKVGDP 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  824 EDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV--GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDF 900
Cdd:COG1012   317 LDPGTDMGPLISEAQLERVLAYIEDAVAEGaELLTGGRRPDGegGYFVEPTVLADVTPDMRIAREEIFGPVLSVIPFDDE 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  901 NEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGAlVGRQPFGGFRLSGAGTKaGGPDYLLHFMDPRV 980
Cdd:COG1012   397 EEAIALANDTEYGLAASVFTRDLARARRVARRLEAGMVWINDGTTGA-VPQAPFGGVKQSGIGRE-GGREGLEEYTETKT 474

                  ....*
gi 221564986  981 VTENT 985
Cdd:COG1012   475 VTIRL 479
ALDH_P5CDH cd07083
ALDH subfamily NAD+-dependent delta(1)-pyrroline-5-carboxylate dehydrogenase-like; ALDH ...
490-984 1.76e-159

ALDH subfamily NAD+-dependent delta(1)-pyrroline-5-carboxylate dehydrogenase-like; ALDH subfamily of the NAD+-dependent, delta(1)-pyrroline-5-carboxylate dehydrogenases (P5CDH, EC=1.5.1.12). The proline catabolic enzymes, proline dehydrogenase and P5CDH catalyze the two-step oxidation of proline to glutamate. P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA). These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis. In certain prokaryotes such as Escherichia coli, PutA is also a transcriptional repressor of the proline utilization genes. Monofunctional enzyme sequences such as those seen in the Bacillus RocA P5CDH are also present in this subfamily as well as the human ALDH4A1 P5CDH and the Drosophila Aldh17 P5CDH.


Pssm-ID: 143402 [Multi-domain]  Cd Length: 500  Bit Score: 479.38  E-value: 1.76e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  490 RQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRA 569
Cdd:cd07083     1 RRAMREALRRVKEEFGRAYPLVIGGEWVDTKERMVSVSPFAPSEVVGTTAKADKAEAEAALEAAWAAFKTWKDWPQEDRA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  570 EFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRL-GSPRSMGKVAGETNQYFYEPKGVAAV 648
Cdd:cd07083    81 RLLLKAADLLRRRRRELIATLTYEVGKNWVEAIDDVAEAIDFIRYYARAALRLrYPAVEVVPYPGEDNESFYVGLGAGVV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  649 IAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFT 728
Cdd:cd07083   161 ISPWNFPVAIFTGMIVAPVAVGNTVIAKPAEDAVVVGYKVFEIFHEAGFPPGVVQFLPGVGEEVGAYLTEHERIRGINFT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  729 GSMEVGLRIIERAAKVQPGQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFV 808
Cdd:cd07083   241 GSLETGKKIYEAAARLAPGQTWFKRLYVETGGKNAIIVDETADFELVVEGVVVSAFGFQGQKCSAASRLILTQGAYEPVL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  809 QRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPE-VGFFVPLTIIGDIRPEHRLAQEEI 887
Cdd:cd07083   321 ERLLKRAERLSVGPPEENGTDLGPVIDAEQEAKVLSYIEHGKNEGQLVLGGKRLEgEGYFVAPTVVEEVPPKARIAQEEI 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  888 FGPLLAVMR--ARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQPFGGFRLSGAGTK 965
Cdd:cd07083   401 FGPVLSVIRykDDDFAEALEVANSTPYGLTGGVYSRKREHLEEARREFHVGNLYINRKITGALVGVQPFGGFKLSGTNAK 480
                         490
                  ....*....|....*....
gi 221564986  966 AGGPDYLLHFMDPRVVTEN 984
Cdd:cd07083   481 TGGPHYLRRFLEMKAVAER 499
PRK11905 PRK11905
bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed
103-976 1.93e-156

bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 237018 [Multi-domain]  Cd Length: 1208  Bit Score: 494.00  E-value: 1.93e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  103 RKAVSTAIRKMAQQFIVGENTTEAISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIeramgrwkplgaG 182
Cdd:PRK11905  165 RKAVDMAMRMMGEQFVTGETIEEALKRARELEARGYRYSYDMLGEAARTAADAERYYRDYERAIHAI------------G 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  183 RTSGSMDWGHAPRInvSVKATALSclasPMdYEGS------------VAAilrrlrlicrrvrevngfLCL-----DM-- 243
Cdd:PRK11905  233 KAATGRGVYDGPGI--SVKLSALH----PR-YERAqrervmaellprLKA------------------LALlakayDIgl 287
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  244 -----ETYRYkEIILEVYRRLkLENPD---YHHLGLVLQSYLRDTDHDLDNLVTWARENCLGISIRLVKGAYWDYEMIRS 315
Cdd:PRK11905  288 nidaeEADRL-ELSLDLLEAL-CSDPDlagWNGIGFVVQAYQKRCPFVIDYLIDLARRSGRRLMVRLVKGAYWDAEIKRA 365
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  316 RQSGLPE-PVWTMKAETDAAFERQARRIMENSDVCHFACASHNIRSISAVIELARElavsDDRYEFQVLYGMAEP----- 389
Cdd:PRK11905  366 QVDGLEGfPVFTRKVHTDVSYIACARKLLAARDVIYPQFATHNAQTLAAIYELAGG----KGDFEFQCLHGMGEPlydqv 441
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  390 VRKAILNRtgRLRLYCPYGPMVPGMGYLVRRLLENTSNVSFLRQTFVDAAGAEKLLEDPLHVVERQRLAVQPRLREGAK- 468
Cdd:PRK11905  442 VGKEKLGR--PCRIYAPVGTHETLLAYLVRRLLENGANSSFVNRIVDENVPVEELIADPVEKVAAMGVAPHPQIPLPRDl 519
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  469 -------SSGkvIPFSNEPVIDfTREEQRQAFREHIGQVRsrfgrkyPLFIGGQEleTEDLLPSMNPSDPSEIVGWVCQA 541
Cdd:PRK11905  520 ygperrnSKG--LDLSDEATLA-ALDEALNAFAAKTWHAA-------PLLAGGDV--DGGTRPVLNPADHDDVVGTVTEA 587
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  542 GTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIR 621
Cdd:PRK11905  588 SAEDVERALAAAQAAFPEWSATPAAERAAILERAADLMEAHMPELFALAVREAGKTLANAIAEVREAVDFLRYYAAQARR 667
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  622 LGSPRSmgkvagetnqyfYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGV 701
Cdd:PRK11905  668 LLNGPG------------HKPLGPVVCISPWNFPLAIFTGQIAAALVAGNTVLAKPAEQTPLIAARAVRLLHEAGVPKDA 735
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  702 FNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRI----IERAAKVQPgqemvkkVICEMGGKNAIIIDDDADLDEAVP 777
Cdd:PRK11905  736 LQLLPGDGRTVGAALVADPRIAGVMFTGSTEVARLIqrtlAKRSGPPVP-------LIAETGGQNAMIVDSSALPEQVVA 808
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  778 HVFNSAFGFQGQKCSACsRVIVL-DGIYDKFVQRLT-ALAEAVpVGpveDPANL---IGAVAEENAQKRIMNYIEVGRQE 852
Cdd:PRK11905  809 DVIASAFDSAGQRCSAL-RVLCLqEDVADRVLTMLKgAMDELR-IG---DPWRLstdVGPVIDAEAQANIEAHIEAMRAA 883
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  853 GRLLYQGHVPEV---GFFVPLTII--GDIrpehRLAQEEIFGPLLAVMR-ARDFNEALVWA-NSTRYALTGGLFSRSPEH 925
Cdd:PRK11905  884 GRLVHQLPLPAEtekGTFVAPTLIeiDSI----SDLEREVFGPVLHVVRfKADELDRVIDDiNATGYGLTFGLHSRIDET 959
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|.
gi 221564986  926 IAIATKRFRVGNLYLNRNCTGALVGRQPFGGFRLSGAGTKAGGPDYLLHFM 976
Cdd:PRK11905  960 IAHVTSRIRAGNIYVNRNIIGAVVGVQPFGGEGLSGTGPKAGGPLYLGRLV 1010
Aldedh pfam00171
Aldehyde dehydrogenase family; This family of dehydrogenases act on aldehyde substrates. ...
523-981 1.33e-153

Aldehyde dehydrogenase family; This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.


Pssm-ID: 425500 [Multi-domain]  Cd Length: 459  Bit Score: 462.39  E-value: 1.33e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   523 LPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAY 602
Cdd:pfam00171    9 IEVINPAT-GEVIATVPAATAEDVDAAIAAARAAFPAWRKTPAAERAAILRKAADLLEERKDELAELETLENGKPLAEAR 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   603 ADVTEAIDFLEYYAREMIRLgSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTS 682
Cdd:pfam00171   88 GEVDRAIDVLRYYAGLARRL-DGETLPSDPGRLAYTRREPLGVVGAITPWNFPLLLPAWKIAPALAAGNTVVLKPSELTP 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   683 IIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKN 762
Cdd:pfam00171  167 LTALLLAELFEEAGLPAGVLNVVTGSGAEVGEALVEHPDVRKVSFTGSTAVGRHIAEAAAQ------NLKRVTLELGGKN 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   763 AIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRI 842
Cdd:pfam00171  241 PLIVLEDADLDAAVEAAVFGAFGNAGQVCTATSRLLVHESIYDEFVEKLVEAAKKLKVGDPLDPDTDMGPLISKAQLERV 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   843 MNYIEVGRQEG-RLLYQGH-VPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFS 920
Cdd:pfam00171  321 LKYVEDAKEEGaKLLTGGEaGLDNGYFVEPTVLANVTPDMRIAQEEIFGPVLSVIRFKDEEEAIEIANDTEYGLAAGVFT 400
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221564986   921 RSPEHIAIATKRFRVGNLYLNRNCTGALVGRqPFGGFRLSGAGtKAGGPDYLLHFMDPRVV 981
Cdd:pfam00171  401 SDLERALRVARRLEAGMVWINDYTTGDADGL-PFGGFKQSGFG-REGGPYGLEEYTEVKTV 459
ALDH_PutA-P5CDH cd07125
Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; The proline catabolic enzymes of the ...
490-989 2.29e-143

Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; The proline catabolic enzymes of the aldehyde dehydrogenase (ALDH) protein superfamily, proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, (EC=1.5.1.12 )), catalyze the two-step oxidation of proline to glutamate; P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA) These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis. In certain prokaryotes such as Escherichia coli, PutA is also a transcriptional repressor of the proline utilization genes.


Pssm-ID: 143443 [Multi-domain]  Cd Length: 518  Bit Score: 438.17  E-value: 2.29e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  490 RQAFREHIGQVRSRFGRKYPlFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRA 569
Cdd:cd07125    16 LEALADALKAFDEKEWEAIP-IINGEETETGEGAPVIDPADHERTIGEVSLADAEDVDAALAIAAAAFAGWSATPVEERA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  570 EFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKVAGETNQYFYEPKGVAAVI 649
Cdd:cd07125    95 EILEKAADLLEANRGELIALAAAEAGKTLADADAEVREAIDFCRYYAAQARELFSDPELPGPTGELNGLELHGRGVFVCI 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  650 APWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTG 729
Cdd:cd07125   175 SPWNFPLAIFTGQIAAALAAGNTVIAKPAEQTPLIAARAVELLHEAGVPRDVLQLVPGDGEEIGEALVAHPRIDGVIFTG 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  730 SMEVGLRIIE-RAAKVQPgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFV 808
Cdd:cd07125   255 STETAKLINRaLAERDGP----ILPLIAETGGKNAMIVDSTALPEQAVKDVVQSAFGSAGQRCSALRLLYLQEEIAERFI 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  809 QRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEV-GFFVPLTII-GDIRPEHrlaQEE 886
Cdd:cd07125   331 EMLKGAMASLKVGDPWDLSTDVGPLIDKPAGKLLRAHTELMRGEAWLIAPAPLDDGnGYFVAPGIIeIVGIFDL---TTE 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  887 IFGPLLAVMRAR--DFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQPFGGFRLSGAGT 964
Cdd:cd07125   408 VFGPILHVIRFKaeDLDEAIEDINATGYGLTLGIHSRDEREIEYWRERVEAGNLYINRNITGAIVGRQPFGGWGLSGTGP 487
                         490       500
                  ....*....|....*....|....*
gi 221564986  965 KAGGPDYLLHFMDPRVVTENTMRRG 989
Cdd:cd07125   488 KAGGPNYLLRFGNEKTVSLNTTAAG 512
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
3-995 1.40e-141

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 448.34  E-value: 1.40e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986    3 DSELNRRIVSCGREMFAGIYGETPSLFDKgrwlgkLMAWSMSDEEFKTRLFRFVDVFPTLSTDRMVADHLEEYFDGAQPP 82
Cdd:COG0506     6 DEALRARAVALARRLVEAIRAAPEGGVEA------LLREYLLSPQEGVALMCLAEALLRLPDNATADRLIRDKLAKSPSF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   83 VLALLRQA--AGVFGPFGNFIQRKAVSTAIRKMAQQFIVGENTTEAISNIERLRHQGFAAVVDVLGEATLSEKEADAYVD 160
Cdd:COG0506    80 LVNASTWGlmLTLVGRLGEPVIRPAVRRAMRRMARRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  161 QYLDLIGSIERAmgrwkplgagrtsgsmdwgHAPRINVSVKATALSCLASPMDYEGSVAAILRRLRLICRRVREVNGFLC 240
Cdd:COG0506   160 AYLEALEAIGAA-------------------GVDRPGVSVKLSALGPRYSPAQRERVVEELLERLRPLARAAREAGIFVT 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  241 LDMETYRYKEIILEVYRRL--KLENPDYHHLGLVLQSYLRDTDHDLDNLVTWARENCLGISIRLVKGAYWDYEMIRSRQS 318
Cdd:COG0506   221 IDMEEYDRLDLTLDVFERLlaDPELAGWPGVGIVLQAYLKRAEADLDRLAALARRGGRRIRVRLVKGAYWDPEIVRAQVH 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  319 GLPEPVWTMKAETDAAFERQARRIMENSDVCHFACASHNIRSISAVIELARELAVSDDRYEFQVLYGMAEPVRKAILN-R 397
Cdd:COG0506   301 GWPYPVFTRKADTDANYLRCARKLLEAGDAIYPQFATHNARTIAAALALAGERGRPPDRFEFQMLYGMGEDLQRALAAvD 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  398 TGRLRLYCPYGPMVPGMGYLVRRLLENTSNVSFLRQTFVDAAGAEKLLEDPlhVVERQRLAVQPRLREGAKSSGKVIPFS 477
Cdd:COG0506   381 GGRLLLYCPVVAPVGGDAALAYLLRRLLENNSFLNFFVADFDDDEDLLEFP--REPPRFLAALAAPTPPPPPPLRRQRRR 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  478 NEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLFIGGQELETEDLLPSMNPSDPS--EIVGWVCQAGTDEVAQAIGAARK 555
Cdd:COG0506   459 RRRARGGALAAALAAAAAAAALAAAAAAAAALAAAAAGAAAAAAAAAVAVVPAAAaaVVAAAAAAAAAAAAAAAAAAAAA 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  556 SFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKVAGET 635
Cdd:COG0506   539 AAAAAAAAAAAAAAAAAAAAAAEAAEAALLLAAAAAEAAAAAALAAAAAEAAAAAAAAAAAAAAARAAAPPPPPPGGLVA 618
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  636 NQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDY 715
Cdd:COG0506   619 LLPLGPLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAALAALLLLLGGAGGGVLVLGAGGGAGGAAA 698
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  716 LVDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQEmvkkVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACS 795
Cdd:COG0506   699 LTLAAAAAAATAATAAAAAAAAALAAAAAAAAAA----AAAAAGGAAAAAAAAAAAAAVAAVAASAAASASASASLLSLL 774
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  796 RVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEV-GFFVPLTIIG 874
Cdd:COG0506   775 ALLLLDADLVILLLALAAAAAALLVGGPGAAALALGIVEDAAAAALLLALAALELGEEELLLPGGGPLVpGLLTAPLLVA 854
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  875 DIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQPF 954
Cdd:COG0506   855 LILGLIVLVLLEIVLVLALVLALALDLAALIGLGLTGGLLGGGGGIVGRRGGGGGAGGRVGGGGGGGGGGGGGGGGGGGG 934
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|.
gi 221564986  955 GGFRLSGAGTKAGGPDYLLHFMDPRVVTENTMRRGFAPAGA 995
Cdd:COG0506   935 GGGGGGGGGGGGGGGGGAGTLALAAAAAAATALAAAAAAAA 975
PutA2 COG4230
Delta 1-pyrroline-5-carboxylate dehydrogenase [Amino acid transport and metabolism];
103-985 5.61e-137

Delta 1-pyrroline-5-carboxylate dehydrogenase [Amino acid transport and metabolism];


Pssm-ID: 443374 [Multi-domain]  Cd Length: 1156  Bit Score: 440.91  E-value: 5.61e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  103 RKAVSTAIRKMAQQFIVGENTTEAISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIERAmgrwkplgAG 182
Cdd:COG4230   166 RRAMRAAMMMMMGLFGVGFVTEEAAEAARKAARKREYYYYDMLGEAAAAAADAAAYAYAYAAAAAAAIAA--------AG 237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  183 RTSGSMDWGHAPRInvSVKATALSCLASPMDYEGSVAAILRRLRLICRRVREVNGFLCLDMETYRYKEIILEVYRRLKLE 262
Cdd:COG4230   238 GGSGGPGPSISSSL--SVLLSARHPRYRRRREERLLLLLLPLLALLALAAININIDEEEDAEELLLLLLLLDLLAALLLD 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  263 NP--DYHHLGLVLQSYLRDTDHDLDnlvtWARENCLGISIRLVKGAYWDYE--MIRSRQSGLPEPVWTMKAETDAAFERQ 338
Cdd:COG4230   316 GGlgGGGGVGQAVQAYAKALLLVLD----LLARRRRRRRRRLVVRLVKGAEwdREIQRAQVLGYVVYPVTTRKVLYDAAA 391
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  339 ARRIMENSDVCHFACASHNirSISAVIELARELAVSDDRYEFQVLYGMAEP----VRKAILNRtgRLRLYCPYG------ 408
Cdd:COG4230   392 LALALLLLAAQPAFAPQFA--THAAATAAAAAAAGGGGEFEFQCLHGMGEYlydqVGRGKLGR--PCRIYAPVGshedll 467
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  409 PmvpgmgYLVRRLLENTSNVSFLRQtFVDAA-GAEKLLEDPLHVVERQRLAVQPRLR--------EGAKSSGkvipfsne 479
Cdd:COG4230   468 A------YLVRRLLENGANSSFVNR-IADEDvPVEELIADPVEKARALGGAPHPRIPlprdlygpERRNSAG-------- 532
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  480 pvIDFTREEQRQAFREHIGQVRSRFGRKYPLfIGGqELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARKSFET 559
Cdd:COG4230   533 --LDLSDEAVLAALSAALAAAAEKQWQAAPL-IAG-EAASGEARPVRNPADHSDVVGTVVEATAADVEAALAAAQAAFPA 608
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  560 WRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSprsmgkvagetNQYF 639
Cdd:COG4230   609 WSATPVEERAAILERAADLLEAHRAELMALLVREAGKTLPDAIAEVREAVDFCRYYAAQARRLFA-----------APTV 677
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  640 YEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDH 719
Cdd:COG4230   678 LRGRGVFVCISPWNFPLAIFTGQVAAALAAGNTVLAKPAEQTPLIAARAVRLLHEAGVPADVLQLLPGDGETVGAALVAD 757
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  720 PHVSLIAFTGSMEVGlRIIERAAKVQPGQEMVkkVICEMGGKNaiiidddadldeaVPHVFNSAFGFQGQKCSACsRVIV 799
Cdd:COG4230   758 PRIAGVAFTGSTETA-RLINRTLAARDGPIVP--LIAETGGQNamivdssalpeqvVDDVLASAFDSAGQRCSAL-RVLC 833
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  800 L-DGIYDKFVQRLT-ALAEAVpVGpveDPANL---IGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEV---GFFVPLT 871
Cdd:COG4230   834 VqEDIADRVLEMLKgAMAELR-VG---DPADLstdVGPVIDAEARANLEAHIERMRAEGRLVHQLPLPEEcanGTFVAPT 909
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  872 I--IGDIRpehRLaQEEIFGPLLAVMR--ARDFnEALVWA-NSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTG 946
Cdd:COG4230   910 LieIDSIS---DL-EREVFGPVLHVVRykADEL-DKVIDAiNATGYGLTLGVHSRIDETIDRVAARARVGNVYVNRNIIG 984
                         890       900       910
                  ....*....|....*....|....*....|....*....
gi 221564986  947 ALVGRQPFGGFRLSGAGTKAGGPDYLLHFMDPRVVTENT 985
Cdd:COG4230   985 AVVGVQPFGGEGLSGTGPKAGGPHYLLRFATERTVTVNT 1023
ALDH cd07078
NAD(P)+ dependent aldehyde dehydrogenase family; The aldehyde dehydrogenase family (ALDH) of ...
548-983 3.91e-132

NAD(P)+ dependent aldehyde dehydrogenase family; The aldehyde dehydrogenase family (ALDH) of NAD(P)+ dependent enzymes, in general, oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an important role in detoxification. Besides aldehyde detoxification, many ALDH isozymes possess multiple additional catalytic and non-catalytic functions such as participating in metabolic pathways, or as binding proteins, or as osmoregulants, to mention a few. The enzyme has three domains, a NAD(P)+ cofactor-binding domain, a catalytic domain, and a bridging domain; and the active enzyme is generally either homodimeric or homotetrameric. The catalytic mechanism is proposed to involve cofactor binding, resulting in a conformational change and activation of an invariant catalytic cysteine nucleophile. The cysteine and aldehyde substrate form an oxyanion thiohemiacetal intermediate resulting in hydride transfer to the cofactor and formation of a thioacylenzyme intermediate. Hydrolysis of the thioacylenzyme and release of the carboxylic acid product occurs, and in most cases, the reduced cofactor dissociates from the enzyme. The evolutionary phylogenetic tree of ALDHs appears to have an initial bifurcation between what has been characterized as the classical aldehyde dehydrogenases, the ALDH family (ALDH) and extended family members or aldehyde dehydrogenase-like (ALDH-like) proteins. The ALDH proteins are represented by enzymes which share a number of highly conserved residues necessary for catalysis and cofactor binding and they include such proteins as retinal dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, delta(1)-pyrroline-5-carboxylate dehydrogenases, alpha-ketoglutaric semialdehyde dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, coniferyl aldehyde dehydrogenase and succinate-semialdehyde dehydrogenase. Included in this larger group are all human, Arabidopsis, Tortula, fungal, protozoan, and Drosophila ALDHs identified in families ALDH1 through ALDH22 with the exception of families ALDH18, ALDH19, and ALDH20 which are present in the ALDH-like group.


Pssm-ID: 143397 [Multi-domain]  Cd Length: 432  Bit Score: 405.82  E-value: 3.91e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  548 QAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRS 627
Cdd:cd07078     2 AAVAAARAAFKAWAALPPAERAAILRKLADLLEERREELAALETLETGKPIEEALGEVARAADTFRYYAGLARRLHGEVI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  628 MGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPG 707
Cdd:cd07078    82 PSPDPGELAIVRREPLGVVGAITPWNFPLLLAAWKLAPALAAGNTVVLKPSELTPLTALLLAELLAEAGLPPGVLNVVTG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  708 RSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQ 787
Cdd:cd07078   162 DGDEVGAALASHPRVDKISFTGSTAVGKAIMRAAA------ENLKRVTLELGGKSPLIVFDDADLDAAVKGAVFGAFGNA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  788 GQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPE--V 864
Cdd:cd07078   236 GQVCTAASRLLVHESIYDEFVERLVERVKALKVGNPLDPDTDMGPLISAAQLDRVLAYIEDAKAEGaKLLCGGKRLEggK 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  865 GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNrNC 944
Cdd:cd07078   316 GYFVPPTVLTDVDPDMPIAQEEIFGPVLPVIPFKDEEEAIELANDTEYGLAAGVFTRDLERALRVAERLEAGTVWIN-DY 394
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 221564986  945 TGALVGRQPFGGFRLSGAGtKAGGPDYLLHFMDPRVVTE 983
Cdd:cd07078   395 SVGAEPSAPFGGVKQSGIG-REGGPYGLEEYTEPKTVTI 432
putA PRK11809
trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate ...
103-996 1.80e-128

trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 236989 [Multi-domain]  Cd Length: 1318  Bit Score: 421.30  E-value: 1.80e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  103 RKAVSTAIRKMAQQFIVGENTTEAISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIERAMGrwkplGAG 182
Cdd:PRK11809  245 RKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTEADAQAYLASYEQAIHAIGKASN-----GRG 319
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  183 RTSGsmdwghaPRInvSVKATALSCLASPMDYEGSVAAILRRLRLICRRVREVNGFLCLDMETYRYKEIILEVYRRLKLE 262
Cdd:PRK11809  320 IYEG-------PGI--SIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGINIDAEEADRLEISLDLLEKLCFE 390
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  263 nPD---YHHLGLVLQSYLRDTDHDLDNLVTWARENCLGISIRLVKGAYWDYEMIRSRQSGLPE-PVWTMKAETDAAFERQ 338
Cdd:PRK11809  391 -PElagWNGIGFVIQAYQKRCPFVIDYLIDLARRSRRRLMIRLVKGAYWDSEIKRAQVDGLEGyPVYTRKVYTDVSYLAC 469
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  339 ARRIMENSDVCHFACASHNIRSISAVIELARELAVSDdRYEFQVLYGMAEP-----VRKAI---LNRTgrLRLYCPYGPM 410
Cdd:PRK11809  470 ARKLLAVPNLIYPQFATHNAHTLAAIYHLAGQNYYPG-QYEFQCLHGMGEPlyeqvVGKVAdgkLNRP--CRIYAPVGTH 546
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  411 VPGMGYLVRRLLENTSNVSFLRQTFVDAAGAEKLLEDPLHVVERqrLAVQ--------PRL--------REGAKSSGkvi 474
Cdd:PRK11809  547 ETLLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVEAVEK--LAQQegqlglphPKIplprdlygKGRANSAG--- 621
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  475 pfsnepvIDFTREEQRQAFREHIGQVRSRFGRKYPLFigGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAAR 554
Cdd:PRK11809  622 -------LDLANEHRLASLSSALLASAHQKWQAAPML--EDPVAAGEMSPVINPADPRDIVGYVREATPAEVEQALESAV 692
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  555 KSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAremirlgsprsmGKVAGE 634
Cdd:PRK11809  693 NAAPIWFATPPAERAAILERAADLMEAQMQTLMGLLVREAGKTFSNAIAEVREAVDFLRYYA------------GQVRDD 760
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  635 TNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGD 714
Cdd:PRK11809  761 FDNDTHRPLGPVVCISPWNFPLAIFTGQVAAALAAGNSVLAKPAEQTPLIAAQAVRILLEAGVPAGVVQLLPGRGETVGA 840
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  715 YLVDHPHVSLIAFTGSMEVGlRIIER--AAKVQPgQEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCS 792
Cdd:PRK11809  841 ALVADARVRGVMFTGSTEVA-RLLQRnlAGRLDP-QGRPIPLIAETGGQNAMIVDSSALTEQVVADVLASAFDSAGQRCS 918
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  793 ACsRVIVL-DGIYDKFVQRLT-ALAEAVpvgpVEDPANL---IGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEV--- 864
Cdd:PRK11809  919 AL-RVLCLqDDVADRTLKMLRgAMAECR----MGNPDRLstdIGPVIDAEAKANIERHIQAMRAKGRPVFQAARENSedw 993
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  865 --GFFVPLTII--GDIrpeHRLaQEEIFGPLLAVMRAR--DFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNL 938
Cdd:PRK11809  994 qsGTFVPPTLIelDSF---DEL-KREVFGPVLHVVRYNrnQLDELIEQINASGYGLTLGVHTRIDETIAQVTGSAHVGNL 1069
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 221564986  939 YLNRNCTGALVGRQPFGGFRLSGAGTKAGGPDYLLHFMDPRvvTENTMRRGFAPAGAG 996
Cdd:PRK11809 1070 YVNRNMVGAVVGVQPFGGEGLSGTGPKAGGPLYLYRLLATR--PEDALAVTLARQDAE 1125
ALDH_KGSADH-YcbD cd07097
Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; ...
508-970 2.49e-122

Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Kinetic studies of the Bacillus subtilis ALDH-like ycbD protein, which is involved in d-glucarate/d-galactarate utilization, reveal that it is a NADP+-dependent, alpha-ketoglutaric semialdehyde dehydrogenase (KGSADH). KGSADHs (EC 1.2.1.26) catalyze the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. Interestingly, the NADP+-dependent, tetrameric, 2,5-dioxopentanoate dehydrogenase (EC=1.2.1.26), an enzyme involved in the catabolic pathway for D-arabinose in Sulfolobus solfataricus, also clusters in this group. This CD shows a distant phylogenetic relationship to the Azospirillum brasilense KGSADH-II (-III) group.


Pssm-ID: 143415 [Multi-domain]  Cd Length: 473  Bit Score: 381.60  E-value: 2.49e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  508 YPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELS 587
Cdd:cd07097     1 YRNYIDGEWVAGGDGEENRNPSDTSDVVGKYARASAEDADAAIAAAAAAFPAWRRTSPEARADILDKAGDELEARKEELA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  588 ALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGS---PRSMGKVAGETNQyfyEPKGVAAVIAPWNFPLAISMGMVS 664
Cdd:cd07097    81 RLLTREEGKTLPEARGEVTRAGQIFRYYAGEALRLSGetlPSTRPGVEVETTR---EPLGVVGLITPWNFPIAIPAWKIA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  665 AAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKV 744
Cdd:cd07097   158 PALAYGNTVVFKPAELTPASAWALVEILEEAGLPAGVFNLVMGSGSEVGQALVEHPDVDAVSFTGSTAVGRRIAAAAAAR 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  745 QpgqemvKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVE 824
Cdd:cd07097   238 G------ARVQLEMGGKNPLVVLDDADLDLAVECAVQGAFFSTGQRCTASSRLIVTEGIHDRFVEALVERTKALKVGDAL 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  825 DPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHV---PEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDF 900
Cdd:cd07097   312 DEGVDIGPVVSERQLEKDLRYIEIARSEGaKLVYGGERlkrPDEGYYLAPALFAGVTNDMRIAREEIFGPVAAVIRVRDY 391
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  901 NEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVgRQPFGGFRLSGAGTKAGGPD 970
Cdd:cd07097   392 DEALAIANDTEFGLSAGIVTTSLKHATHFKRRVEAGVVMVNLPTAGVDY-HVPFGGRKGSSYGPREQGEA 460
Pro_dh pfam01619
Proline dehydrogenase;
126-433 8.87e-113

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 349.87  E-value: 8.87e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   126 AISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIERAMGRWKPlgagrtsgsmdwghAPRINVSVKATAL 205
Cdd:pfam01619    1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALGKAAGPWPL--------------GPRPGISVKLSAL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   206 SCLASPMDYEGSVAAILRRLRLICRRVREVNGFLCLDMETYRYKEIILEVYRRL--KLENPDYHHLGLVLQSYLRDTDHD 283
Cdd:pfam01619   67 HPRYEPLERERVMAELLERLRPLCRLAKELGVRLNIDAEEADRLDLTLDLFERLlaEPELRGWNGVGITLQAYLKDALAV 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   284 LDNLVTWARENCLGISIRLVKGAYWDYEMIRSRQSGLPEPVWTMKAETDAAFERQARRIMENSDVCHFACASHNIRSISA 363
Cdd:pfam01619  147 LDWLLELARRRGRPLGVRLVKGAYWDSEIKRAQQGGWPYPVFTRKEATDANYEACARFLLENHDRIYPQFATHNARSVAA 226
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   364 VIELARELAVSDDRYEFQVLYGMAEPVRKAILNRTGRLRLYCPYGPMVPGMGYLVRRLLENTSNVSFLRQ 433
Cdd:pfam01619  227 ALALAEELGIPPRRFEFQQLYGMGDNLSFALVAAGYRVRKYAPVGPHEELLAYLVRRLLENTANSSFVRR 296
ALDH_AldH-CAJ73105 cd07131
Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; ...
511-984 2.29e-109

Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105) and similar sequences with similarity to alpha-aminoadipic semialdehyde dehydrogenase (AASADH, human ALDH7A1, EC=1.2.1.31), Arabidopsis ALDH7B4, and Streptomyces clavuligerus delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH) are included in this CD.


Pssm-ID: 143449 [Multi-domain]  Cd Length: 478  Bit Score: 347.80  E-value: 2.29e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  511 FIGGQELE--TEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSA 588
Cdd:cd07131     2 YIGGEWVDsaSGETFDSRNPADLEEVVGTFPLSTASDVDAAVEAAREAFPEWRKVPAPRRAEYLFRAAELLKKRKEELAR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  589 LQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIV 668
Cdd:cd07131    82 LVTREMGKPLAEGRGDVQEAIDMAQYAAGEGRRLFGETVPSELPNKDAMTRRQPIGVVALITPWNFPVAIPSWKIFPALV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  669 TGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVQpgq 748
Cdd:cd07131   162 CGNTVVFKPAEDTPACALKLVELFAEAGLPPGVVNVVHGRGEEVGEALVEHPDVDVVSFTGSTEVGERIGETCARPN--- 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  749 emvKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPAN 828
Cdd:cd07131   239 ---KRVALEMGGKNPIIVMDDADLDLALEGALWSAFGTTGQRCTATSRLIVHESVYDEFLKRFVERAKRLRVGDGLDEET 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  829 LIGAVAEENAQKRIMNYIEVGRQEGRLLYQG------HVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNE 902
Cdd:cd07131   316 DMGPLINEAQLEKVLNYNEIGKEEGATLLLGgerltgGGYEKGYFVEPTVFTDVTPDMRIAQEEIFGPVVALIEVSSLEE 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  903 ALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVgRQPFGGFRLSGAGTKAGGPDYLLHFMDPRVVT 982
Cdd:cd07131   396 AIEIANDTEYGLSSAIYTEDVNKAFRARRDLEAGITYVNAPTIGAEV-HLPFGGVKKSGNGHREAGTTALDAFTEWKAVY 474

                  ..
gi 221564986  983 EN 984
Cdd:cd07131   475 VD 476
ALDH_F4-17_P5CDH cd07123
Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Delta(1) ...
478-984 1.37e-105

Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.


Pssm-ID: 143441 [Multi-domain]  Cd Length: 522  Bit Score: 339.18  E-value: 1.37e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  478 NEPVIDFTR-EEQRQAFREHIGQVRSRFgRKYPLFIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARKS 556
Cdd:cd07123     3 NEPVLSYAPgSPERAKLQEALAELKSLT-VEIPLVIGGKEVRTGNTGKQVMPHDHAHVLATYHYADAALVEKAIEAALEA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  557 FETWrDITP-EIRAEFLLKACTVV--RRRiYELSALQVLEIGKQWDQAYAD-VTEAIDFLE---YYAREMIRlGSPRSmg 629
Cdd:cd07123    82 RKEW-ARMPfEDRAAIFLKAADLLsgKYR-YELNAATMLGQGKNVWQAEIDaACELIDFLRfnvKYAEELYA-QQPLS-- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  630 KVAGETNQYFYEP-KGVAAVIAPWNFPlAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGR 708
Cdd:cd07123   157 SPAGVWNRLEYRPlEGFVYAVSPFNFT-AIGGNLAGAPALMGNVVLWKPSDTAVLSNYLVYKILEEAGLPPGVINFVPGD 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  709 SGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAA------KVQPgqemvkKVICEMGGKNAIIIDDDADLDEAVPHVFNS 782
Cdd:cd07123   236 GPVVGDTVLASPHLAGLHFTGSTPTFKSLWKQIGenldryRTYP------RIVGETGGKNFHLVHPSADVDSLVTATVRG 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  783 AFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQ--EGRLLYQGH 860
Cdd:cd07123   310 AFEYQGQKCSAASRAYVPESLWPEVKERLLEELKEIKMGDPDDFSNFMGAVIDEKAFDRIKGYIDHAKSdpEAEIIAGGK 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  861 V-PEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLA--VMRARDFNEAL-VWANSTRYALTGGLFSRSPEHIAIATKRFR-- 934
Cdd:cd07123   390 CdDSVGYFVEPTVIETTDPKHKLMTEEIFGPVLTvyVYPDSDFEETLeLVDTTSPYALTGAIFAQDRKAIREATDALRna 469
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 221564986  935 VGNLYLNRNCTGALVGRQPFGGFRLSGAGTKAGGPDYLLHFMDPRVVTEN 984
Cdd:cd07123   470 AGNFYINDKPTGAVVGQQPFGGARASGTNDKAGSPLNLLRWVSPRTIKET 519
ALDH-SF cd06534
NAD(P)+-dependent aldehyde dehydrogenase superfamily; The aldehyde dehydrogenase superfamily ...
552-983 1.70e-102

NAD(P)+-dependent aldehyde dehydrogenase superfamily; The aldehyde dehydrogenase superfamily (ALDH-SF) of NAD(P)+-dependent enzymes, in general, oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an important role in detoxification. Besides aldehyde detoxification, many ALDH isozymes possess multiple additional catalytic and non-catalytic functions such as participating in metabolic pathways, or as binding proteins, or osmoregulants, to mention a few. The enzyme has three domains, a NAD(P)+ cofactor-binding domain, a catalytic domain, and a bridging domain; and the active enzyme is generally either homodimeric or homotetrameric. The catalytic mechanism is proposed to involve cofactor binding, resulting in a conformational change and activation of an invariant catalytic cysteine nucleophile. The cysteine and aldehyde substrate form an oxyanion thiohemiacetal intermediate resulting in hydride transfer to the cofactor and formation of a thioacylenzyme intermediate. Hydrolysis of the thioacylenzyme and release of the carboxylic acid product occurs, and in most cases, the reduced cofactor dissociates from the enzyme. The evolutionary phylogenetic tree of ALDHs appears to have an initial bifurcation between what has been characterized as the classical aldehyde dehydrogenases, the ALDH family (ALDH) and extended family members or aldehyde dehydrogenase-like (ALDH-L) proteins. The ALDH proteins are represented by enzymes which share a number of highly conserved residues necessary for catalysis and cofactor binding and they include such proteins as retinal dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, delta(1)-pyrroline-5-carboxylate dehydrogenases, alpha-ketoglutaric semialdehyde dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, coniferyl aldehyde dehydrogenase and succinate-semialdehyde dehydrogenase. Included in this larger group are all human, Arabidopsis, Tortula, fungal, protozoan, and Drosophila ALDHs identified in families ALDH1 through ALDH22 with the exception of families ALDH18, ALDH19, and ALDH20 which are present in the ALDH-like group. The ALDH-like group is represented by such proteins as gamma-glutamyl phosphate reductase, LuxC-like acyl-CoA reductase, and coenzyme A acylating aldehyde dehydrogenase. All of these proteins have a conserved cysteine that aligns with the catalytic cysteine of the ALDH group.


Pssm-ID: 143395 [Multi-domain]  Cd Length: 367  Bit Score: 325.34  E-value: 1.70e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  552 AARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKV 631
Cdd:cd06534     2 AARAAFKAWAALPPAERAAILRKIADLLEERREELAALETLETGKPIEEALGEVARAIDTFRYAAGLADKLGGPELPSPD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  632 AGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGI 711
Cdd:cd06534    82 PGGEAYVRREPLGVVGVITPWNFPLLLAAWKLAPALAAGNTVVLKPSELTPLTALALAELLQEAGLPPGVVNVVPGGGDE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  712 MGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKC 791
Cdd:cd06534   162 VGAALLSHPRVDKISFTGSTAVGKAIMKAAA------ENLKPVTLELGGKSPVIVDEDADLDAAVEGAVFGAFFNAGQIC 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  792 SACSRVIVLDGIYDKFVQRLtalaeavpvgpvedpanligavaeenaqkrimnyievgrqegrllyqghvpevgffvpLT 871
Cdd:cd06534   236 TAASRLLVHESIYDEFVEKL----------------------------------------------------------VT 257
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  872 IIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGAlVGR 951
Cdd:cd06534   258 VLVDVDPDMPIAQEEIFGPVLPVIRFKDEEEAIALANDTEYGLTAGVFTRDLNRALRVAERLRAGTVYINDSSIGV-GPE 336
                         410       420       430
                  ....*....|....*....|....*....|..
gi 221564986  952 QPFGGFRLSGAGtKAGGPDYLLHFMDPRVVTE 983
Cdd:cd06534   337 APFGGVKNSGIG-REGGPYGLEEYTRTKTVVI 367
ALDH_F8_HMSADH cd07093
Human aldehyde dehydrogenase family 8 member A1-like; In humans, the aldehyde dehydrogenase ...
525-982 1.61e-98

Human aldehyde dehydrogenase family 8 member A1-like; In humans, the aldehyde dehydrogenase family 8 member A1 (ALDH8A1) protein functions to convert 9-cis-retinal to 9-cis-retinoic acid and has a preference for NAD+. Also included in this CD is the 2-hydroxymuconic semialdehyde dehydrogenase (HMSADH) which catalyzes the conversion of 2-hydroxymuconic semialdehyde to 4-oxalocrotonate, a step in the meta cleavage pathway of aromatic hydrocarbons in bacteria. Such HMSADHs seen here are: XylG of the TOL plasmid pWW0 of Pseudomonas putida, TomC of Burkholderia cepacia G4, and AphC of Comamonas testosterone.


Pssm-ID: 143412 [Multi-domain]  Cd Length: 455  Bit Score: 317.97  E-value: 1.61e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  525 SMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQ-WDQAYA 603
Cdd:cd07093     1 NFNPAT-GEVLAKVPEGGAAEVDAAVAAAKEAFPGWSRMSPAERARILHKVADLIEARADELALLESLDTGKPiTLARTR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  604 DVTEAIDFLEYYArEMIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSI 683
Cdd:cd07093    80 DIPRAAANFRFFA-DYILQLDGESYPQDGGALNYVLRQPVGVAGLITPWNLPLMLLTWKIAPALAFGNTVVLKPSEWTPL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  684 IGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNA 763
Cdd:cd07093   159 TAWLLAELANEAGLPPGVVNVVHGFGPEAGAALVAHPDVDLISFTGETATGRTIMRAAAP------NLKPVSLELGGKNP 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  764 IIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIM 843
Cdd:cd07093   233 NIVFADADLDRAVDAAVRSSFSNNGEVCLAGSRILVQRSIYDEFLERFVERAKALKVGDPLDPDTEVGPLISKEHLEKVL 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  844 NYIEVGRQEG-RLLYQGHVPEV-----GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGG 917
Cdd:cd07093   313 GYVELARAEGaTILTGGGRPELpdlegGYFVEPTVITGLDNDSRVAQEEIFGPVVTVIPFDDEEEAIELANDTPYGLAAY 392
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221564986  918 LFSRSPEHIAIATKRFRVGNLYLNRNCTGALvgRQPFGGFRLSGAGTKagGPDYLLHF-MDPRVVT 982
Cdd:cd07093   393 VWTRDLGRAHRVARRLEAGTVWVNCWLVRDL--RTPFGGVKASGIGRE--GGDYSLEFyTELKNVC 454
ALDH_CddD-AldA-like cd07089
Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; The 6-oxolauric ...
527-981 7.83e-97

Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid; and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and also, the Mycobacterium tuberculosis H37Rv ALDH AldA (locus Rv0768) sequence; and other similar sequences, are included in this CD.


Pssm-ID: 143408 [Multi-domain]  Cd Length: 459  Bit Score: 313.80  E-value: 7.83e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETW-RDITPEIRAEFLLKACTVVRRRIYELSALQVLEIG--------KQ 597
Cdd:cd07089     3 NPAT-EEVIGTAPDAGAADVDAAIAAARRAFDTGdWSTDAEERARCLRQLHEALEARKEELRALLVAEVGapvmtaraMQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  598 WDQAYADVTEAIDFLEYYAREMIRLGSP----RSMGKVAgetnqyfYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCV 673
Cdd:cd07089    82 VDGPIGHLRYFADLADSFPWEFDLPVPAlrggPGRRVVR-------REPVGVVAAITPWNFPFFLNLAKLAPALAAGNTV 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  674 VFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKK 753
Cdd:cd07089   155 VLKPAPDTPLSALLLGEIIAETDLPAGVVNVVTGSDNAVGEALTTDPRVDMVSFTGSTAVGRRIMAQAA------ATLKR 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  754 VICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAV 833
Cdd:cd07089   229 VLLELGGKSANIVLDDADLAAAAPAAVGVCMHNAGQGCALTTRLLVPRSRYDEVVEALAAAFEALPVGDPADPGTVMGPL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  834 AEENAQKRIMNYIEVGRQEG-RLLYQGHVP---EVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANS 909
Cdd:cd07089   309 ISAAQRDRVEGYIARGRDEGaRLVTGGGRPaglDKGFYVEPTLFADVDNDMRIAQEEIFGPVLVVIPYDDDDEAVRIAND 388
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221564986  910 TRYALTGGLFSRSPEH-IAIAtKRFRVGNLYLNrncTGALVGRQ-PFGGFRLSGAGtKAGGPDYLLHFMDPRVV 981
Cdd:cd07089   389 SDYGLSGGVWSADVDRaYRVA-RRIRTGSVGIN---GGGGYGPDaPFGGYKQSGLG-RENGIEGLEEFLETKSI 457
ALDH_F1-2_Ald2-like cd07091
ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD ...
510-967 1.49e-96

ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; ALDH subfamily which includes the NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36), also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1), in humans, a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism. 10-formyltetrahydrofolate dehydrogenase (FTHFDH, EC=1.5.1.6), also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1), in humans, a multi-domain homotetramer with an N-terminal formyl transferase domain and a C-terminal ALDH domain. FTHFDH catalyzes an NADP+-dependent dehydrogenase reaction resulting in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. Also included in this subfamily is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial, homotetramers that oxidize acetaldehyde and glycolaldehyde, as well as, the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde. Also included is the AldA aldehyde dehydrogenase of Aspergillus nidulans (locus AN0554), the aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) of Saccharomyces cerevisiae, and other similar sequences.


Pssm-ID: 143410  Cd Length: 476  Bit Score: 313.38  E-value: 1.49e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQ--ELETEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFET--WRDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:cd07091     6 LFINNEfvDSVSGKTFPTINPAT-EEVICQVAEADEEDVDAAVKAARAAFETgwWRKMDPRERGRLLNKLADLIERDRDE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  586 LSALQVLEIGKQWDQAY-ADVTEAIDFLEYYAremirlgsprsmG---KVAGET-----NQYFY---EPKGVAAVIAPWN 653
Cdd:cd07091    85 LAALESLDNGKPLEESAkGDVALSIKCLRYYA------------GwadKIQGKTipidgNFLAYtrrEPIGVCGQIIPWN 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  654 FPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEV 733
Cdd:cd07091   153 FPLLMLAWKLAPALAAGNTVVLKPAEQTPLSALYLAELIKEAGFPPGVVNIVPGFGPTAGAAISSHMDVDKIAFTGSTAV 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  734 GLRIIERAAKVQpgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTA 813
Cdd:cd07091   233 GRTIMEAAAKSN-----LKKVTLELGGKSPNIVFDDADLDKAVEWAAFGIFFNQGQCCCAGSRIFVQESIYDEFVEKFKA 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  814 LAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQG-HVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPL 891
Cdd:cd07091   308 RAEKRVVGDPFDPDTFQGPQVSKAQFDKILSYIESGKKEGaTLLTGGeRHGSKGYFIQPTVFTDVKDDMKIAKEEIFGPV 387
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221564986  892 LAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGTKAG 967
Cdd:cd07091   388 VTILKFKTEDEVIERANDTEYGLAAGVFTKDINKALRVSRALKAGTVWV--NTYNVFDAAVPFGGFKQSGFGRELG 461
ALDH_HMSADH_HapE cd07115
Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; 4-hydroxymuconic ...
525-981 5.03e-96

Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; 4-hydroxymuconic semialdehyde dehydrogenase (HapE, EC=1.2.1.61) of Pseudomonas fluorescens ACB involved in 4-hydroxyacetophenone degradation, and putative hydroxycaproate semialdehyde dehydrogenase (ChnE) of Brachymonas petroleovorans involved in cyclohexane metabolism, and other similar sequences, are present in this CD.


Pssm-ID: 143433 [Multi-domain]  Cd Length: 453  Bit Score: 311.30  E-value: 5.03e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  525 SMNPSDPSEIvGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQW-DQAYA 603
Cdd:cd07115     1 TLNPATGELI-ARVAQASAEDVDAAVAAARAAFEAWSAMDPAERGRILWRLAELILANADELARLESLDTGKPIrAARRL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  604 DVTEAIDFLEYYAremirlGSPRsmgKVAGET--------NQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVF 675
Cdd:cd07115    80 DVPRAADTFRYYA------GWAD---KIEGEVipvrgpflNYTVREPVGVVGAIVPWNFPLMFAAWKVAPALAAGNTVVL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  676 KPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKKVI 755
Cdd:cd07115   151 KPAELTPLSALRIAELMAEAGFPAGVLNVVTGFGEVAGAALVEHPDVDKITFTGSTAVGRKIMQGAA------GNLKRVS 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  756 CEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAE 835
Cdd:cd07115   225 LELGGKSANIVFADADLDAAVRAAATGIFYNQGQMCTAGSRLLVHESIYDEFLERFTSLARSLRPGDPLDPKTQMGPLVS 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  836 ENAQKRIMNYIEVGRQEG-RLLYQGHVP-EVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYA 913
Cdd:cd07115   305 QAQFDRVLDYVDVGREEGaRLLTGGKRPgARGFFVEPTIFAAVPPEMRIAQEEIFGPVVSVMRFRDEEEALRIANGTEYG 384
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221564986  914 LTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGtKAGGPDYLLHFMDPRVV 981
Cdd:cd07115   385 LAAGVWTRDLGRAHRVAAALKAGTVWI--NTYNRFDPGSPFGGYKQSGFG-REMGREALDEYTEVKSV 449
ALDH_AAS00426 cd07109
Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; ...
527-967 2.44e-93

Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Uncharacterized aldehyde dehydrogenase of Saccharopolyspora spinosa (AAS00426) and other similar sequences, are present in this CD.


Pssm-ID: 143427 [Multi-domain]  Cd Length: 454  Bit Score: 304.16  E-value: 2.44e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDpSEIVGWVCQAGTDEVAQAIGAARKSFET-WRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADV 605
Cdd:cd07109     3 DPST-GEVFARIARGGAADVDRAVQAARRAFESgWLRLSPAERGRLLLRIARLIREHADELARLESLDTGKPLTQARADV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  606 TEAIDFLEYYARemirlgsprSMGKVAGET----NQYF----YEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKP 677
Cdd:cd07109    82 EAAARYFEYYGG---------AADKLHGETiplgPGYFvytvREPHGVTGHIIPWNYPLQITGRSVAPALAAGNAVVVKP 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  678 SGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKKVICE 757
Cdd:cd07109   153 AEDAPLTALRLAELAEEAGLPAGALNVVTGLGAEAGAALVAHPGVDHISFTGSVETGIAVMRAAA------ENVVPVTLE 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  758 MGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLiGAVAEEN 837
Cdd:cd07109   227 LGGKSPQIVFADADLEAALPVVVNAIIQNAGQTCSAGSRLLVHRSIYDEVLERLVERFRALRVGPGLEDPDL-GPLISAK 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  838 AQKRIMNYIEVGRQEG-RLLYQGHV----PEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRY 912
Cdd:cd07109   306 QLDRVEGFVARARARGaRIVAGGRIaegaPAGGYFVAPTLLDDVPPDSRLAQEEIFGPVLAVMPFDDEAEAIALANGTDY 385
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 221564986  913 ALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQ-PFGGFRLSGAGTKAG 967
Cdd:cd07109   386 GLVAGVWTRDGDRALRVARRLRAGQVFV--NNYGAGGGIElPFGGVKKSGHGREKG 439
ALDH_F7_AASADH-like cd07086
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase and related proteins; ALDH ...
511-967 4.45e-93

NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase and related proteins; ALDH subfamily which includes the NAD+-dependent, alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as Antiquitin-1, ALDH7A1, ALDH7B or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), and other similar sequences, such as the uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105).


Pssm-ID: 143405 [Multi-domain]  Cd Length: 478  Bit Score: 304.10  E-value: 4.45e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  511 FIGGQELE-TEDLLPSMNPSDPSEIVGwVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSAL 589
Cdd:cd07086     2 VIGGEWVGsGGETFTSRNPANGEPIAR-VFPASPEDVEAAVAAAREAFKEWRKVPAPRRGEIVRQIGEALRKKKEALGRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  590 QVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLG-----SPRSmGKVAGEtnqyFYEPKGVAAVIAPWNFPLAISMGMVS 664
Cdd:cd07086    81 VSLEMGKILPEGLGEVQEMIDICDYAVGLSRMLYgltipSERP-GHRLME----QWNPLGVVGVITAFNFPVAVPGWNAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  665 AAIVTGNCVVFKPSGLTSIIGWQLVDIFREV----GLPDGVFNFVPGRSGImGDYLVDHPHVSLIAFTGSMEVGLRIIER 740
Cdd:cd07086   156 IALVCGNTVVWKPSETTPLTAIAVTKILAEVleknGLPPGVVNLVTGGGDG-GELLVHDPRVPLVSFTGSTEVGRRVGET 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  741 AAKvqpgqeMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPV 820
Cdd:cd07086   235 VAR------RFGRVLLELGGNNAIIVMDDADLDLAVRAVLFAAVGTAGQRCTTTRRLIVHESVYDEFLERLVKAYKQVRI 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  821 GPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV---GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMR 896
Cdd:cd07086   309 GDPLDEGTLVGPLINQAAVEKYLNAIEIAKSQGgTVLTGGKRIDGgepGNYVEPTIVTGVTDDARIVQEETFAPILYVIK 388
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221564986  897 ARDFNEALVWANSTRYALTGGLFSRSPEHIAiatkRFR------VGNLYLNRNCTGALVGrQPFGGFRLSGAGTKAG 967
Cdd:cd07086   389 FDSLEEAIAINNDVPQGLSSSIFTEDLREAF----RWLgpkgsdCGIVNVNIPTSGAEIG-GAFGGEKETGGGRESG 460
ALDH_LactADH-AldA cd07088
Escherichia coli lactaldehyde dehydrogenase AldA-like; Lactaldehyde dehydrogenase from ...
511-981 1.41e-92

Escherichia coli lactaldehyde dehydrogenase AldA-like; Lactaldehyde dehydrogenase from Escherichia coli (AldA, LactADH, EC=1.2.1.22), an NAD(+)-dependent enzyme involved in the metabolism of L-fucose and L-rhamnose, and other similar sequences are present in this CD.


Pssm-ID: 143407 [Multi-domain]  Cd Length: 468  Bit Score: 302.65  E-value: 1.41e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  511 FIGGQ--ELETEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSA 588
Cdd:cd07088     1 YINGEfvPSSSGETIDVLNPAT-GEVVATVPAATAEDADRAVDAAEAAQKAWERLPAIERAAYLRKLADLIRENADELAK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  589 LQVLEIGKQWDQAYADVTEAIDFLEYYArEMIRlgspRSMGKV-----AGETNQYFYEPKGVAAVIAPWNFPLAISMGMV 663
Cdd:cd07088    80 LIVEEQGKTLSLARVEVEFTADYIDYMA-EWAR----RIEGEIipsdrPNENIFIFKVPIGVVAGILPWNFPFFLIARKL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  664 SAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAk 743
Cdd:cd07088   155 APALVTGNTIVIKPSEETPLNALEFAELVDEAGLPAGVLNIVTGRGSVVGDALVAHPKVGMISLTGSTEAGQKIMEAAA- 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  744 vqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPV 823
Cdd:cd07088   234 -----ENITKVSLELGGKAPAIVMKDADLDLAVKAIVDSRIINCGQVCTCAERVYVHEDIYDEFMEKLVEKMKAVKVGDP 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  824 EDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV--GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDF 900
Cdd:cd07088   309 FDAATDMGPLVNEAALDKVEEMVERAVEAGaTLLTGGKRPEGekGYFYEPTVLTNVRQDMEIVQEEIFGPVLPVVKFSSL 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  901 NEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALvgrQPF-GGFRLSGAGtKAGGPDYLLHFMDPR 979
Cdd:cd07088   389 DEAIELANDSEYGLTSYIYTENLNTAMRATNELEFGETYINRENFEAM---QGFhAGWKKSGLG-GADGKHGLEEYLQTK 464

                  ..
gi 221564986  980 VV 981
Cdd:cd07088   465 VV 466
ALDH_CddD_SSP0762 cd07138
Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; The 6-oxolauric acid dehydrogenase ...
510-963 2.20e-92

Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid, and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and other similar sequences, are included in this CD.


Pssm-ID: 143456 [Multi-domain]  Cd Length: 466  Bit Score: 301.73  E-value: 2.20e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQ--ELETEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELS 587
Cdd:cd07138     1 FYIDGAwvAPAGTETIDVINPAT-EEVIGTVPLGTAADVDRAVAAARRAFPAWSATSVEERAALLERIAEAYEARADELA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  588 ALQVLEIG-----KQWDQA---------YADVTEAIDFLEYYAREMIRlgsprsmgkvagetnqyfYEPKGVAAVIAPWN 653
Cdd:cd07138    80 QAITLEMGapitlARAAQVglgighlraAADALKDFEFEERRGNSLVV------------------REPIGVCGLITPWN 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  654 FPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEV 733
Cdd:cd07138   142 WPLNQIVLKVAPALAAGCTVVLKPSEVAPLSAIILAEILDEAGLPAGVFNLVNGDGPVVGEALSAHPDVDMVSFTGSTRA 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  734 GLRIIERAAkvqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTA 813
Cdd:cd07138   222 GKRVAEAAA------DTVKRVALELGGKSANIILDDADLEKAVPRGVAACFANSGQSCNAPTRMLVPRSRYAEAEEIAAA 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  814 LAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQG----HVPEVGFFVPLTIIGDIRPEHRLAQEEIF 888
Cdd:cd07138   296 AAEAYVVGDPRDPATTLGPLASAAQFDRVQGYIQKGIEEGaRLVAGGpgrpEGLERGYFVKPTVFADVTPDMTIAREEIF 375
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221564986  889 GPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRnctGALVGRQPFGGFRLSGAG 963
Cdd:cd07138   376 GPVLSIIPYDDEDEAIAIANDTPYGLAGYVWSADPERARAVARRLRAGQVHING---AAFNPGAPFGGYKQSGNG 447
ALDH_F5_SSADH_GabD cd07103
Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; ...
527-982 1.35e-91

Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.


Pssm-ID: 143421 [Multi-domain]  Cd Length: 451  Bit Score: 299.35  E-value: 1.35e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVT 606
Cdd:cd07103     3 NPAT-GEVIGEVPDAGAADADAAIDAAAAAFKTWRKTTARERAAILRRWADLIRERAEDLARLLTLEQGKPLAEARGEVD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  607 EAIDFLEYYAREmirlgSPRSMGKV-----AGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLT 681
Cdd:cd07103    82 YAASFLEWFAEE-----ARRIYGRTipspaPGKRILVIKQPVGVVAAITPWNFPAAMITRKIAPALAAGCTVVLKPAEET 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  682 SIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKKVICEMGGk 761
Cdd:cd07103   157 PLSALALAELAEEAGLPAGVLNVVTGSPAEIGEALCASPRVRKISFTGSTAVGKLLMAQAA------DTVKRVSLELGG- 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  762 naiiidddadldeavpH----VFNSA-------------FGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVE 824
Cdd:cd07103   230 ----------------NapfiVFDDAdldkavdgaiaskFRNAGQTCVCANRIYVHESIYDEFVEKLVERVKKLKVGNGL 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  825 DPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGH-VPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNE 902
Cdd:cd07103   294 DEGTDMGPLINERAVEKVEALVEDAVAKGaKVLTGGKrLGLGGYFYEPTVLTDVTDDMLIMNEETFGPVAPIIPFDTEDE 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  903 ALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNrncTGALVGRQ-PFGGFRLSGAGtKAGGPDYLLHFMDPRVV 981
Cdd:cd07103   374 VIARANDTPYGLAAYVFTRDLARAWRVAEALEAGMVGIN---TGLISDAEaPFGGVKESGLG-REGGKEGLEEYLETKYV 449

                  .
gi 221564986  982 T 982
Cdd:cd07103   450 S 450
ALDH_F10_BADH cd07110
Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Present in ...
526-967 2.11e-91

Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Present in this CD are the Arabidopsis betaine aldehyde dehydrogenase (BADH) 1 (chloroplast) and 2 (mitochondria), also known as, aldehyde dehydrogenase family 10 member A8 and aldehyde dehydrogenase family 10 member A9, respectively, and are putative dehydration- and salt-inducible BADHs (EC 1.2.1.8) that catalyze the oxidation of betaine aldehyde to the compatible solute glycine betaine.


Pssm-ID: 143428 [Multi-domain]  Cd Length: 456  Bit Score: 298.88  E-value: 2.11e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  526 MNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADV 605
Cdd:cd07110     2 INPAT-EATIGEIPAATAEDVDAAVRAARRAFPRWKKTTGAERAKYLRAIAEGVRERREELAELEARDNGKPLDEAAWDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  606 TEAIDFLEYYAR--EMIRLGSPRSmgkVAGETNQY----FYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSG 679
Cdd:cd07110    81 DDVAGCFEYYADlaEQLDAKAERA---VPLPSEDFkarvRREPVGVVGLITPWNFPLLMAAWKVAPALAAGCTVVLKPSE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  680 LTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKKVICEMG 759
Cdd:cd07110   158 LTSLTELELAEIAAEAGLPPGVLNVVTGTGDEAGAPLAAHPGIDKISFTGSTATGSQVMQAAA------QDIKPVSLELG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  760 GKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQ 839
Cdd:cd07110   232 GKSPIIVFDDADLEKAVEWAMFGCFWNNGQICSATSRLLVHESIADAFLERLATAAEAIRVGDPLEEGVRLGPLVSQAQY 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  840 KRIMNYIEVGRQEG-RLLYQGHVPEV---GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALT 915
Cdd:cd07110   312 EKVLSFIARGKEEGaRLLCGGRRPAHlekGYFIAPTVFADVPTDSRIWREEIFGPVLCVRSFATEDEAIALANDSEYGLA 391
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 221564986  916 GGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGTKAG 967
Cdd:cd07110   392 AAVISRDAERCDRVAEALEAGIVWI--NCSQPCFPQAPWGGYKRSGIGRELG 441
ALDH_BADH-GbsA cd07119
Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Included in this CD is ...
511-985 3.81e-90

Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Included in this CD is the NAD+-dependent, betaine aldehyde dehydrogenase (BADH, GbsA, EC=1.2.1.8) of Bacillus subtilis involved in the synthesis of the osmoprotectant glycine betaine from choline or glycine betaine aldehyde.


Pssm-ID: 143437  Cd Length: 482  Bit Score: 296.53  E-value: 3.81e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  511 FIGGQ--ELETEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFET--WRDITPEIRAEFLLKACTVVRRRIYEL 586
Cdd:cd07119     1 YIDGEwvEAASGKTRDIINPAN-GEVIATVPEGTAEDAKRAIAAARRAFDSgeWPHLPAQERAALLFRIADKIREDAEEL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  587 SALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSprSMGKVAGETNQY-FYEPKGVAAVIAPWNFPLAISMGMVSA 665
Cdd:cd07119    80 ARLETLNTGKTLRESEIDIDDVANCFRYYAGLATKETG--EVYDVPPHVISRtVREPVGVCGLITPWNYPLLQAAWKLAP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  666 AIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvq 745
Cdd:cd07119   158 ALAAGNTVVIKPSEVTPLTTIALFELIEEAGLPAGVVNLVTGSGATVGAELAESPDVDLVSFTGGTATGRSIMRAAA--- 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  746 pgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVED 825
Cdd:cd07119   235 ---GNVKKVALELGGKNPNIVFADADFETAVDQALNGVFFNAGQVCSAGSRLLVEESIHDKFVAALAERAKKIKLGNGLD 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  826 PANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPE-----VGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARD 899
Cdd:cd07119   312 ADTEMGPLVSAEHREKVLSYIQLGKEEGaRLVCGGKRPTgdelaKGYFVEPTIFDDVDRTMRIVQEEIFGPVLTVERFDT 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  900 FNEALVWANSTRYALTGGLFSRSpehIAIA---TKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGtKAGGPDYLLHFM 976
Cdd:cd07119   392 EEEAIRLANDTPYGLAGAVWTKD---IARAnrvARRLRAGTVWI--NDYHPYFAEAPWGGYKQSGIG-RELGPTGLEEYQ 465

                  ....*....
gi 221564986  977 DPRVVTENT 985
Cdd:cd07119   466 ETKHININL 474
ALDH_AldA-Rv0768 cd07139
Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; The Mycobacterium tuberculosis ...
510-982 1.75e-89

Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.


Pssm-ID: 143457 [Multi-domain]  Cd Length: 471  Bit Score: 294.48  E-value: 1.75e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQ--ELETEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFE--TWRDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:cd07139     1 LFIGGRwvAPSGSETIDVVSPAT-EEVVGRVPEATPADVDAAVAAARRAFDngPWPRLSPAERAAVLRRLADALEARADE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  586 LSALQVLEIGK-QWDQAYADVTEAIDFLEYYAR-------EMIRLGSPRSMGKVAgetnqyfYEPKGVAAVIAPWNFPLA 657
Cdd:cd07139    80 LARLWTAENGMpISWSRRAQGPGPAALLRYYAAlardfpfEERRPGSGGGHVLVR-------REPVGVVAAIVPWNAPLF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  658 ISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGImGDYLVDHPHVSLIAFTGSMEVGLRI 737
Cdd:cd07139   153 LAALKIAPALAAGCTVVLKPSPETPLDAYLLAEAAEEAGLPPGVVNVVPADREV-GEYLVRHPGVDKVSFTGSTAAGRRI 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  738 IERAAkvqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEA 817
Cdd:cd07139   232 AAVCG------ERLARVTLELGGKSAAIVLDDADLDAAVPGLVPASLMNNGQVCVALTRILVPRSRYDEVVEALAAAVAA 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  818 VPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV---GFFVPLTIIGDIRPEHRLAQEEIFGPLLA 893
Cdd:cd07139   306 LKVGDPLDPATQIGPLASARQRERVEGYIAKGRAEGaRLVTGGGRPAGldrGWFVEPTLFADVDNDMRIAQEEIFGPVLS 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  894 VMRARDFNEALVWANSTRYALTGGLFSRSPEH-IAIAtKRFRVGNLYLN--RNCTGAlvgrqPFGGFRLSGAGtKAGGPD 970
Cdd:cd07139   386 VIPYDDEDDAVRIANDSDYGLSGSVWTADVERgLAVA-RRIRTGTVGVNgfRLDFGA-----PFGGFKQSGIG-REGGPE 458
                         490
                  ....*....|..
gi 221564986  971 YLLHFMDPRVVT 982
Cdd:cd07139   459 GLDAYLETKSIY 470
ALDH_VaniDH_like cd07150
Pseudomonas putida vanillin dehydrogenase-like; Vanillin dehydrogenase (Vdh, VaniDH) involved ...
523-982 2.93e-89

Pseudomonas putida vanillin dehydrogenase-like; Vanillin dehydrogenase (Vdh, VaniDH) involved in the metabolism of ferulic acid and other related sequences are included in this CD. The E. coli vanillin dehydrogenase (LigV) preferred NAD+ to NADP+ and exhibited a broad substrate preference, including vanillin, benzaldehyde, protocatechualdehyde, m-anisaldehyde, and p-hydroxybenzaldehyde.


Pssm-ID: 143468 [Multi-domain]  Cd Length: 451  Bit Score: 293.08  E-value: 2.93e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  523 LPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAY 602
Cdd:cd07150     1 FDDLNPAD-GSVYARVAVGSRQDAERAIAAAYDAFPAWAATTPSERERILLKAAEIMERRADDLIDLLIDEGGSTYGKAW 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  603 ADVTEAIDFLEYyAREMIRlgspRSMGKV-----AGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKP 677
Cdd:cd07150    80 FETTFTPELLRA-AAGECR----RVRGETlpsdsPGTVSMSVRRPLGVVAGITPFNYPLILATKKVAFALAAGNTVVLKP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  678 SGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICE 757
Cdd:cd07150   155 SEETPVIGLKIAEIMEEAGLPKGVFNVVTGGGAEVGDELVDDPRVRMVTFTGSTAVGREIAEKAGR------HLKKITLE 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  758 MGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEEN 837
Cdd:cd07150   229 LGGKNPLIVLADADLDYAVRAAAFGAFMHQGQICMSASRIIVEEPVYDEFVKKFVARASKLKVGDPRDPDTVIGPLISPR 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  838 AQKRIMNYIEVGRQEG-RLLYQGHVpEVGFFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTG 916
Cdd:cd07150   309 QVERIKRQVEDAVAKGaKLLTGGKY-DGNFYQP-TVLTDVTPDMRIFREETFGPVTSVIPAKDAEEALELANDTEYGLSA 386
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221564986  917 GLFSRSpEHIAIA-TKRFRVGNLYLnrNCTGALVGRQ-PFGGFRLSGAGtKAGGPDYLLHFMDPRVVT 982
Cdd:cd07150   387 AILTND-LQRAFKlAERLESGMVHI--NDPTILDEAHvPFGGVKASGFG-REGGEWSMEEFTELKWIT 450
ALDH_BenzADH-like cd07104
ALDH subfamily: NAD(P)+-dependent benzaldehyde dehydrogenase II, vanillin dehydrogenase, ...
545-969 5.26e-89

ALDH subfamily: NAD(P)+-dependent benzaldehyde dehydrogenase II, vanillin dehydrogenase, p-hydroxybenzaldehyde dehydrogenase and related proteins; ALDH subfamily which includes the NAD(P)+-dependent, benzaldehyde dehydrogenase II (XylC, BenzADH, EC=1.2.1.28) involved in the oxidation of benzyl alcohol to benzoate; p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes the oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid; vanillin dehydrogenase (Vdh, VaniDH) involved in the metabolism of ferulic acid as seen in Pseudomonas putida KT2440; and other related sequences.


Pssm-ID: 143422 [Multi-domain]  Cd Length: 431  Bit Score: 291.74  E-value: 5.26e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  545 EVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLeyyaREMIRLGS 624
Cdd:cd07104     1 DVDRAYAAAAAAQKAWAATPPQERAAILRKAAEILEERRDEIADWLIRESGSTRPKAAFEVGAAIAIL----REAAGLPR 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  625 pRSMGKV-----AGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSI-IGWQLVDIFREVGLP 698
Cdd:cd07104    77 -RPEGEIlpsdvPGKESMVRRVPLGVVGVISPFNFPLILAMRSVAPALALGNAVVLKPDSRTPVtGGLLIAEIFEEAGLP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  699 DGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNaiiidddadldeavPH 778
Cdd:cd07104   156 KGVLNVVPGGGSEIGDALVEHPRVRMISFTGSTAVGRHIGELAGR------HLKKVALELGGNN--------------PL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  779 V---------------FnSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIM 843
Cdd:cd07104   216 IvlddadldlavsaaaF-GAFLHQGQICMAAGRILVHESVYDEFVEKLVAKAKALPVGDPRDPDTVIGPLINERQVDRVH 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  844 NYIEVGRQEG-RLLYQGHVpeVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRS 922
Cdd:cd07104   295 AIVEDAVAAGaRLLTGGTY--EGLFYQPTVLSDVTPDMPIFREEIFGPVAPVIPFDDDEEAVELANDTEYGLSAAVFTRD 372
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 221564986  923 PEH-IAIAtKRFRVGNLYLNR---NCtGALVgrqPFGGFRLSGaGTKAGGP 969
Cdd:cd07104   373 LERaMAFA-ERLETGMVHINDqtvND-EPHV---PFGGVKASG-GGRFGGP 417
D1pyr5carbox3 TIGR01238
delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain); This model represents ...
477-979 1.37e-88

delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain); This model represents one of several related branches of delta-1-pyrroline-5-carboxylate dehydrogenase. Members of this branch are the C-terminal domain of the PutA bifunctional proline dehydrogenase / delta-1-pyrroline-5-carboxylate dehydrogenase. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273518 [Multi-domain]  Cd Length: 500  Bit Score: 292.97  E-value: 1.37e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   477 SNEPVIDFTREEQRQAFREHIGQVRSRFGRKYPLfIGGQELETEDLLPSMNPSDPSEIVGWVCQAGTDEVAQAIGAARKS 556
Cdd:TIGR01238    8 KNSLGIDLDNESELKPLEAQIHAWADKTWQAAPI-IGHSYKADGEAQPVTNPADRRDIVGQVFHANLAHVQAAIDSAQQA 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   557 FETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAremirlgsprsmGKVAGETN 636
Cdd:TIGR01238   87 FPTWNATPAKERAAKLDRLADLLELHMPELMALCVREAGKTIHNAIAEVREAVDFCRYYA------------KQVRDVLG 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   637 QYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYL 716
Cdd:TIGR01238  155 EFSVESRGVFVCISPWNFPLAIFTGQISAALAAGNTVIAKPAEQTSLIAYRAVELMQEAGFPAGTIQLLPGRGADVGAAL 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   717 VDHPHVSLIAFTGSMEVGLRIIERAAKVQPGQemvKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSR 796
Cdd:TIGR01238  235 TSDPRIAGVAFTGSTEVAQLINQTLAQREDAP---VPLIAETGGQNAMIVDSTALPEQVVRDVLRSAFDSAGQRCSALRV 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   797 VIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQ-----GHVPEVGFFVPLT 871
Cdd:TIGR01238  312 LCVQEDVADRVLTMIQGAMQELKVGVPHLLTTDVGPVIDAEAKQNLLAHIEHMSQTQKKIAQltlddSRACQHGTFVAPT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   872 IIgDIRPEHRLaQEEIFGPLLAVMR--ARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALV 949
Cdd:TIGR01238  392 LF-ELDDIAEL-SEEVFGPVLHVVRykARELDQIVDQINQTGYGLTMGVHSRIETTYRWIEKHARVGNCYVNRNQVGAVV 469
                          490       500       510
                   ....*....|....*....|....*....|
gi 221564986   950 GRQPFGGFRLSGAGTKAGGPDYLLHFMDPR 979
Cdd:TIGR01238  470 GVQPFGGQGLSGTGPKAGGPHYLYRLTQVQ 499
ALDH_DhaS cd07114
Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Uncharacterized ...
525-967 9.64e-86

Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Uncharacterized aldehyde dehydrogenase from Candidatus pelagibacter (DhaS) and other related sequences are present in this CD.


Pssm-ID: 143432 [Multi-domain]  Cd Length: 457  Bit Score: 283.67  E-value: 9.64e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  525 SMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFET--WRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAY 602
Cdd:cd07114     1 SINPAT-GEPWARVPEASAADVDRAVAAARAAFEGgaWRKLTPTERGKLLRRLADLIEANAEELAELETRDNGKLIRETR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  603 ADVTEAIDFLEYYA--REMIRlGS--PRSMGKVAGETNqyfYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPS 678
Cdd:cd07114    80 AQVRYLAEWYRYYAglADKIE-GAviPVDKGDYLNFTR---REPLGVVAAITPWNSPLLLLAKKLAPALAAGNTVVLKPS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  679 GLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVqpgqemVKKVICEM 758
Cdd:cd07114   156 EHTPASTLELAKLAEEAGFPPGVVNVVTGFGPETGEALVEHPLVAKIAFTGGTETGRHIARAAAEN------LAPVTLEL 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  759 GGKNaiiidddadldeavPH-VFNSA-------------FGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVE 824
Cdd:cd07114   230 GGKS--------------PNiVFDDAdldaavngvvagiFAAAGQTCVAGSRLLVQRSIYDEFVERLVARARAIRVGDPL 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  825 DPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV-----GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRAR 898
Cdd:cd07114   296 DPETQMGPLATERQLEKVERYVARAREEGaRVLTGGERPSGadlgaGYFFEPTILADVTNDMRIAQEEVFGPVLSVIPFD 375
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221564986  899 DFNEALVWANSTRYALTGGLFSRSpehIAIA---TKRFRVGNLYLN--RnctgALVGRQPFGGFRLSGAGTKAG 967
Cdd:cd07114   376 DEEEAIALANDSEYGLAAGIWTRD---LARAhrvARAIEAGTVWVNtyR----ALSPSSPFGGFKDSGIGRENG 442
ALDH_SNDH cd07118
Gluconobacter oxydans L-sorbosone dehydrogenase-like; Included in this CD is the L-sorbosone ...
540-967 1.09e-85

Gluconobacter oxydans L-sorbosone dehydrogenase-like; Included in this CD is the L-sorbosone dehydrogenase (SNDH) from Gluconobacter oxydans UV10. In G. oxydans, D-sorbitol is converted to 2-keto-L-gulonate (a precursor of L-ascorbic acid) in sequential oxidation steps catalyzed by a FAD-dependent, L-sorbose dehydrogenase and an NAD(P)+-dependent, L-sorbosone dehydrogenase.


Pssm-ID: 143436 [Multi-domain]  Cd Length: 454  Bit Score: 283.46  E-value: 1.09e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  540 QAGTDEVAQAIGAARKSFET--WRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAr 617
Cdd:cd07118    15 EGTVEDVDAAVAAARKAFDKgpWPRMSGAERAAVLLKVADLIRARRERLALIETLESGKPISQARGEIEGAADLWRYAA- 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  618 emirlGSPRSMgkvAGETNQ---------YFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQL 688
Cdd:cd07118    94 -----SLARTL---HGDSYNnlgddmlglVLREPIGVVGIITPWNFPFLILSQKLPFALAAGCTVVVKPSEFTSGTTLML 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  689 VDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNAIIIDD 768
Cdd:cd07118   166 AELLIEAGLPAGVVNIVTGYGATVGQAMTEHPDVDMVSFTGSTRVGKAIAAAAAR------NLKKVSLELGGKNPQIVFA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  769 DADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEV 848
Cdd:cd07118   240 DADLDAAADAVVFGVYFNAGECCNSGSRLLVHESIADAFVAAVVARSRKVRVGDPLDPETKVGAIINEAQLAKITDYVDA 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  849 GRQEGRLLYQGH---VPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEH 925
Cdd:cd07118   320 GRAEGATLLLGGerlASAAGLFYQPTIFTDVTPDMAIAREEIFGPVLSVLTFDTVDEAIALANDTVYGLSAGVWSKDIDT 399
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 221564986  926 IAIATKRFRVGNLYLNRNCTGAlvGRQPFGGFRLSGAGTKAG 967
Cdd:cd07118   400 ALTVARRIRAGTVWVNTFLDGS--PELPFGGFKQSGIGRELG 439
ALDH_GABALDH-PuuC cd07112
Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase ...
523-977 7.50e-85

Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; NADP+-dependent, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase (GABALDH) PuuC of Escherichia coli which catalyzes the conversion of putrescine to 4-aminobutanoate and other similar sequences are present in this CD.


Pssm-ID: 143430 [Multi-domain]  Cd Length: 462  Bit Score: 281.41  E-value: 7.50e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  523 LPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFE--TWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQ 600
Cdd:cd07112     4 FATINPAT-GRVLAEVAACDAADVDRAVAAARRAFEsgVWSRLSPAERKAVLLRLADLIEAHRDELALLETLDMGKPISD 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  601 AYA-DVTEAIDFLEYYArEMIrlgsPRSMGKVAGETNQYF----YEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVF 675
Cdd:cd07112    83 ALAvDVPSAANTFRWYA-EAI----DKVYGEVAPTGPDALalitREPLGVVGAVVPWNFPLLMAAWKIAPALAAGNSVVL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  676 KPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAakvqpGQEMVKKVI 755
Cdd:cd07112   158 KPAEQSPLTALRLAELALEAGLPAGVLNVVPGFGHTAGEALGLHMDVDALAFTGSTEVGRRFLEYS-----GQSNLKRVW 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  756 CEMGGKNAIIIDD-DADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVA 834
Cdd:cd07112   233 LECGGKSPNIVFAdAPDLDAAAEAAAAGIFWNQGEVCSAGSRLLVHESIKDEFLEKVVAAAREWKPGDPLDPATRMGALV 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  835 EENAQKRIMNYIEVGRQEG-RLLYQG---HVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANST 910
Cdd:cd07112   313 SEAHFDKVLGYIESGKAEGaRLVAGGkrvLTETGGFFVEPTVFDGVTPDMRIAREEIFGPVLSVITFDSEEEAVALANDS 392
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221564986  911 RYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGagtkaGGPDYLLHFMD 977
Cdd:cd07112   393 VYGLAASVWTSDLSRAHRVARRLRAGTVWV--NCFDEGDITTPFGGFKQSG-----NGRDKSLHALD 452
ALDH_F6_MMSDH cd07085
Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Methylmalonate ...
509-983 1.51e-83

Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.


Pssm-ID: 143404 [Multi-domain]  Cd Length: 478  Bit Score: 278.63  E-value: 1.51e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  509 PLFIGGQ--ELETEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYEL 586
Cdd:cd07085     2 KLFINGEwvESKTTEWLDVYNPAT-GEVIARVPLATAEEVDAAVAAAKAAFPAWSATPVLKRQQVMFKFRQLLEENLDEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  587 SALQVLEIGKQWDQAYADVTEAIDFLEYyAREMIRLGSPRSMGKVAGETNQYFY-EPKGVAAVIAPWNFPLAISMGMVSA 665
Cdd:cd07085    81 ARLITLEHGKTLADARGDVLRGLEVVEF-ACSIPHLLKGEYLENVARGIDTYSYrQPLGVVAGITPFNFPAMIPLWMFPM 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  666 AIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGrSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVQ 745
Cdd:cd07085   160 AIACGNTFVLKPSERVPGAAMRLAELLQEAGLPDGVLNVVHG-GKEAVNALLDHPDIKAVSFVGSTPVGEYIYERAAANG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  746 pgqemvKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVED 825
Cdd:cd07085   239 ------KRVQALGGAKNHAVVMPDADLEQTANALVGAAFGAAGQRCMALSVAVAVGDEADEWIPKLVERAKKLKVGAGDD 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  826 PANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV-----GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARD 899
Cdd:cd07085   313 PGADMGPVISPAAKERIEGLIESGVEEGaKLVLDGRGVKVpgyenGNFVGPTILDNVTPDMKIYKEEIFGPVLSIVRVDT 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  900 FNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNrncTG--ALVGRQPFGGFRLSGAG-TKAGGPDYLLHFM 976
Cdd:cd07085   393 LDEAIAIINANPYGNGAAIFTRSGAAARKFQREVDAGMVGIN---VPipVPLAFFSFGGWKGSFFGdLHFYGKDGVRFYT 469

                  ....*..
gi 221564986  977 DPRVVTE 983
Cdd:cd07085   470 QTKTVTS 476
ALDH_y4uC cd07149
Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; ...
533-982 4.96e-83

Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Uncharacterized aldehyde dehydrogenase (ORF name y4uC) with sequence similarity to the moss Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123) believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and similar sequences are included in this CD.


Pssm-ID: 143467 [Multi-domain]  Cd Length: 453  Bit Score: 276.40  E-value: 4.96e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  533 EIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFL 612
Cdd:cd07149    10 EVIGRVPVASEEDVEKAIAAAKEGAKEMKSLPAYERAEILERAAQLLEERREEFARTIALEAGKPIKDARKEVDRAIETL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  613 EYYAREMIRL--------GSPRSMGKVAgetnqYFY-EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSI 683
Cdd:cd07149    90 RLSAEEAKRLagetipfdASPGGEGRIG-----FTIrEPIGVVAAITPFNFPLNLVAHKVGPAIAAGNAVVLKPASQTPL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  684 IGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqemVKKVICEMGGKNA 763
Cdd:cd07149   165 SALKLAELLLEAGLPKGALNVVTGSGETVGDALVTDPRVRMISFTGSPAVGEAIARKAG--------LKKVTLELGSNAA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  764 IIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIM 843
Cdd:cd07149   237 VIVDADADLEKAVERCVSGAFANAGQVCISVQRIFVHEDIYDEFLERFVAATKKLVVGDPLDEDTDVGPMISEAEAERIE 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  844 NYIEVGRQEGRLLYQGHVPEVGFFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSP 923
Cdd:cd07149   317 EWVEEAVEGGARLLTGGKRDGAILEP-TVLTDVPPDMKVVCEEVFAPVVSLNPFDTLDEAIAMANDSPYGLQAGVFTNDL 395
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  924 EHIAIATKRFRVGNLYLNRNCTgALVGRQPFGGFRLSGAGTKagGPDYLLHFM-DPRVVT 982
Cdd:cd07149   396 QKALKAARELEVGGVMINDSST-FRVDHMPYGGVKESGTGRE--GPRYAIEEMtEIKLVC 452
ALDH_AldA-AAD23400 cd07106
Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Putative ...
527-981 7.38e-83

Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Putative aldehyde dehydrogenase, AldA, from Streptomyces aureofaciens (locus AAD23400) and other similar sequences are present in this CD.


Pssm-ID: 143424 [Multi-domain]  Cd Length: 446  Bit Score: 275.56  E-value: 7.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDPsEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVT 606
Cdd:cd07106     3 NPATG-EVFASAPVASEAQLDQAVAAAKAAFPGWSATPLEERRAALLAIADAIEANAEELARLLTLEQGKPLAEAQFEVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  607 EAIDFLEYYAR-----EMIRLGSPRsmgKVAGEtnqyfYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLT 681
Cdd:cd07106    82 GAVAWLRYTASldlpdEVIEDDDTR---RVELR-----RKPLGVVAAIVPWNFPLLLAAWKIAPALLAGNTVVLKPSPFT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  682 SIIGWQLVDIFREVgLPDGVFNFVPGRSGImGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVqpgqemVKKVICEMGGK 761
Cdd:cd07106   154 PLCTLKLGELAQEV-LPPGVLNVVSGGDEL-GPALTSHPDIRKISFTGSTATGKKVMASAAKT------LKRVTLELGGN 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  762 NAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVaeENAQ-- 839
Cdd:cd07106   226 DAAIVLPDVDIDAVAPKLFWGAFINSGQVCAAIKRLYVHESIYDEFCEALVALAKAAVVGDGLDPGTTLGPV--QNKMqy 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  840 KRIMNYIEVGRQEG-RLLYQGHVPEV-GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGG 917
Cdd:cd07106   304 DKVKELVEDAKAKGaKVLAGGEPLDGpGYFIPPTIVDDPPEGSRIVDEEQFGPVLPVLKYSDEDEVIARANDSEYGLGAS 383
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221564986  918 LFSRSPEH-IAIAtKRFRVGNLYLNRNctGALVGRQPFGGFRLSGAGTkAGGPDYLLHFMDPRVV 981
Cdd:cd07106   384 VWSSDLERaEAVA-RRLEAGTVWINTH--GALDPDAPFGGHKQSGIGV-EFGIEGLKEYTQTQVI 444
ALDH_HBenzADH cd07151
NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; NADP+-dependent, ...
515-963 1.79e-82

NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.


Pssm-ID: 143469 [Multi-domain]  Cd Length: 465  Bit Score: 274.95  E-value: 1.79e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  515 QELETEDLLPSMNPSDPSEIVGwVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEI 594
Cdd:cd07151     4 RDGTSERTIDVLNPYTGETLAE-IPAASKEDVDEAYRAAAAAQKEWAATLPQERAEILEKAAQILEERRDEIVEWLIRES 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  595 GK-------QWDQAYADVTEAIDFleyyareMIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAI 667
Cdd:cd07151    83 GStrikaniEWGAAMAITREAATF-------PLRMEGRILPSDVPGKENRVYREPLGVVGVISPWNFPLHLSMRSVAPAL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  668 VTGNCVVFKPSGLTSIIGWQLV-DIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVqp 746
Cdd:cd07151   156 ALGNAVVLKPASDTPITGGLLLaKIFEEAGLPKGVLNVVVGAGSEIGDAFVEHPVPRLISFTGSTPVGRHIGELAGRH-- 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  747 gqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDP 826
Cdd:cd07151   234 ----LKKVALELGGNNPFVVLEDADIDAAVNAAVFGKFLHQGQICMAINRIIVHEDVYDEFVEKFVERVKALPYGDPSDP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  827 ANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVpeVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALV 905
Cdd:cd07151   310 DTVVGPLINESQVDGLLDKIEQAVEEGaTLLVGGEA--EGNVLEPTVLSDVTNDMEIAREEIFGPVAPIIKADDEEEALE 387
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221564986  906 WANSTRYALTGGLFSRSPEH-IAIAtKRFRVGNLYLNRNCtgalVGRQP---FGGFRLSGAG 963
Cdd:cd07151   388 LANDTEYGLSGAVFTSDLERgVQFA-RRIDAGMTHINDQP----VNDEPhvpFGGEKNSGLG 444
ALDH_ABALDH-YdcW cd07092
Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; NAD ...
530-964 6.33e-82

Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; NAD+-dependent, tetrameric, gamma-aminobutyraldehyde dehydrogenase (ABALDH), YdcW of Escherichia coli K12, catalyzes the oxidation of gamma-aminobutyraldehyde to gamma-aminobutyric acid. ABALDH can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.


Pssm-ID: 143411 [Multi-domain]  Cd Length: 450  Bit Score: 273.05  E-value: 6.33e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  530 DPS--EIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYAD-VT 606
Cdd:cd07092     3 DPAtgEEIATVPDASAADVDAAVAAAHAAFPSWRRTTPAERSKALLKLADAIEENAEELAALESRNTGKPLHLVRDDeLP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  607 EAIDFLEYYAremirlGSPRSM-GKVAGE-----TNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGL 680
Cdd:cd07092    83 GAVDNFRFFA------GAARTLeGPAAGEylpghTSMIRREPIGVVAQIAPWNYPLMMAAWKIAPALAAGNTVVLKPSET 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  681 TSIIGWQLVDIFREVgLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGG 760
Cdd:cd07092   157 TPLTTLLLAELAAEV-LPPGVVNVVCGGGASAGDALVAHPRVRMVSLTGSVRTGKKVARAAAD------TLKRVHLELGG 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  761 KNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQK 840
Cdd:cd07092   230 KAPVIVFDDADLDAAVAGIATAGYYNAGQDCTAACRVYVHESVYDEFVAALVEAVSAIRVGDPDDEDTEMGPLNSAAQRE 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  841 RIMNYIEVGRQEGRLLYQGHVPEV-GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLF 919
Cdd:cd07092   310 RVAGFVERAPAHARVLTGGRRAEGpGYFYEPTVVAGVAQDDEIVQEEIFGPVVTVQPFDDEDEAIELANDVEYGLASSVW 389
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 221564986  920 SRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGT 964
Cdd:cd07092   390 TRDVGRAMRLSARLDFGTVWV--NTHIPLAAEMPHGGFKQSGYGK 432
BADH TIGR01804
betaine-aldehyde dehydrogenase; Under osmotic stress, betaine aldehyde dehydrogenase oxidizes ...
511-967 1.35e-81

betaine-aldehyde dehydrogenase; Under osmotic stress, betaine aldehyde dehydrogenase oxidizes glycine betaine aldehyde into the osmoprotectant glycine betaine, via the second of two oxidation steps from exogenously supplied choline or betaine aldehyde. This choline-glycine betaine synthesis pathway can be found in gram-positive and gram-negative bacteria. In Escherichia coli, betaine aldehyde dehydrogenase (betB) is osmotically co-induced with choline dehydrogenase (betA) in the presence of choline. These dehydrogenases are located in a betaine gene cluster with the upstream choline transporter (betT) and transcriptional regulator (betI). Similar to E.coli, betaine synthesis in Staphylococcus xylosus is also influenced by osmotic stress and the presence of choline with genes localized in a functionally equivalent gene cluster. Organization of the betaine gene cluster in Sinorhizobium meliloti and Bacillus subtilis differs from that of E.coli by the absence of upstream choline transporter and transcriptional regulator homologues. Additionally, B.subtilis co-expresses a type II alcohol dehydrogenase with betaine aldehyde dehydrogenase instead of choline dehydrogenase as in E.coli, St.xylosus, and Si.meliloti. Betaine aldehyde dehydrogenase is a member of the aldehyde dehydrogenase family (pfam00171). [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 200131 [Multi-domain]  Cd Length: 467  Bit Score: 272.84  E-value: 1.35e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   511 FIGGQ--ELETEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSA 588
Cdd:TIGR01804    1 FIDGEyvEDSAGTTREIINPAN-GEVIATVHAATPEDVERAIAAARRAQGEWAAMSPMERGRILRRAADLIRERNEELAK 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   589 LQVLEIGKQWDQA-YADVTEAIDFLEYYAR-------EMIRLGSPrSMGKVAgetnqyfYEPKGVAAVIAPWNFPLAISM 660
Cdd:TIGR01804   80 LETLDTGKTLQETiVADMDSGADVFEFFAGlapalngEIIPLGGP-SFAYTI-------REPLGVCVGIGAWNYPLQIAS 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   661 GMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIER 740
Cdd:TIGR01804  152 WKIAPALAAGNAMVFKPSENTPLTALKVAEIMEEAGLPKGVFNVVQGDGAEVGPLLVNHPDVAKVSFTGGVPTGKKIMAA 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   741 AAkvqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPV 820
Cdd:TIGR01804  232 AA------GHLKHVTMELGGKSPLIVFDDADLESAVDGAMLGNFFSAGQVCSNGTRVFVHKKIKERFLARLVERTERIKL 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   821 GPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV-----GFFVPLTIIGDIRPEHRLAQEEIFGPLLAV 894
Cdd:TIGR01804  306 GDPFDEATEMGPLISAAHRDKVLSYIEKGKAEGaTLATGGGRPENvglqnGFFVEPTVFADCTDDMTIVREEIFGPVMTV 385
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221564986   895 MRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNR-NCTGALVgrqPFGGFRLSGAGTKAG 967
Cdd:TIGR01804  386 LTFSDEDEVIARANDTEYGLAGGVFTADLGRAHRVADQLEAGTVWINTyNLYPAEA---PFGGYKQSGIGRENG 456
ALDH_PhdK-like cd07107
Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Nocardioides sp. strain ...
525-967 1.56e-81

Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Nocardioides sp. strain KP72-carboxybenzaldehyde dehydrogenase (PhdK), an enzyme involved in phenanthrene degradation, and other similar sequences, are present in this CD.


Pssm-ID: 143425 [Multi-domain]  Cd Length: 456  Bit Score: 272.33  E-value: 1.56e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  525 SMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYAD 604
Cdd:cd07107     1 VINPAT-GQVLARVPAASAADVDRAVAAARAAFPEWRATTPLERARMLRELATRLREHAEELALIDALDCGNPVSAMLGD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  605 VTEAIDFLEYYAREMIRLGSpRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSII 684
Cdd:cd07107    80 VMVAAALLDYFAGLVTELKG-ETIPVGGRNLHYTLREPYGVVARIVAFNHPLMFAAAKIAAPLAAGNTVVVKPPEQAPLS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  685 GWQLVDIFREVgLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGlRIIERAAKvqpgqEMVKKVICEMGGKNAI 764
Cdd:cd07107   159 ALRLAELAREV-LPPGVFNILPGDGATAGAALVRHPDVKRIALIGSVPTG-RAIMRAAA-----EGIKHVTLELGGKNAL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  765 IIDDDADLDEAV-PHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIM 843
Cdd:cd07107   232 IVFPDADPEAAAdAAVAGMNFTWCGQSCGSTSRLFVHESIYDEVLARVVERVAAIKVGDPTDPATTMGPLVSRQQYDRVM 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  844 NYIEVGRQEG-RLLY-----QGHVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGG 917
Cdd:cd07107   312 HYIDSAKREGaRLVTgggrpEGPALEGGFYVEPTVFADVTPGMRIAREEIFGPVLSVLRWRDEAEMVAQANGVEYGLTAA 391
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 221564986  918 LFSRSPEHIAIATKRFRVGNLYLN---RNCTGAlvgrqPFGGFRLSGAGTKAG 967
Cdd:cd07107   392 IWTNDISQAHRTARRVEAGYVWINgssRHFLGA-----PFGGVKNSGIGREEC 439
ALDH_ALD2-YMR170C cd07144
Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c)-like; NAD(P)+-dependent ...
505-967 1.10e-79

Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c)-like; NAD(P)+-dependent Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) and other similar sequences, are present in this CD.


Pssm-ID: 143462  Cd Length: 484  Bit Score: 268.12  E-value: 1.10e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  505 GRKY--P--LFIGGQELETED--LLPSMNPSDPSEIVGWVCqAGTDEVAQAIGAARKSFET-WRDITPEIRAEFLLKACT 577
Cdd:cd07144     1 GKSYdqPtgLFINNEFVKSSDgeTIKTVNPSTGEVIASVYA-AGEEDVDKAVKAARKAFESwWSKVTGEERGELLDKLAD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  578 VVRRRIYELSALQVLEIGKQWDQ-AYADVTEAIDFLEYYAremirlGSPRSM-GKVAGETNQYF----YEPKGVAAVIAP 651
Cdd:cd07144    80 LVEKNRDLLAAIEALDSGKPYHSnALGDLDEIIAVIRYYA------GWADKIqGKTIPTSPNKLaytlHEPYGVCGQIIP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  652 WNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSM 731
Cdd:cd07144   154 WNYPLAMAAWKLAPALAAGNTVVIKPAENTPLSLLYFANLVKEAGFPPGVVNIIPGYGAVAGSALAEHPDVDKIAFTGST 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  732 EVGlRIIERAAkvqpGQEMvKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRL 811
Cdd:cd07144   234 ATG-RLVMKAA----AQNL-KAVTLECGGKSPALVFEDADLDQAVKWAAAGIMYNSGQNCTATSRIYVQESIYDKFVEKF 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  812 TA-LAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHV----PEVGFFVPLTIIGDIRPEHRLAQE 885
Cdd:cd07144   308 VEhVKQNYKVGSPFDDDTVVGPQVSKTQYDRVLSYIEKGKKEGaKLVYGGEKapegLGKGYFIPPTIFTDVPQDMRIVKE 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  886 EIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSrspEHIAIA---TKRFRVGNLYLNRNCTGALvgRQPFGGFRLSGA 962
Cdd:cd07144   388 EIFGPVVVISKFKTYEEAIKKANDTTYGLAAAVFT---KDIRRAhrvARELEAGMVWINSSNDSDV--GVPFGGFKMSGI 462

                  ....*
gi 221564986  963 GTKAG 967
Cdd:cd07144   463 GRELG 467
ALDH_F9_TMBADH cd07090
NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; NAD+-dependent, ...
527-967 2.06e-78

NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; NAD+-dependent, 4-trimethylaminobutyraldehyde dehydrogenase (TMABADH, EC=1.2.1.47), also known as aldehyde dehydrogenase family 9 member A1 (ALDH9A1) in humans, is a cytosolic tetramer which catalyzes the oxidation of gamma-aminobutyraldehyde involved in 4-aminobutyric acid (GABA) biosynthesis and also oxidizes betaine aldehyde (gamma-trimethylaminobutyraldehyde) which is involved in carnitine biosynthesis.


Pssm-ID: 143409 [Multi-domain]  Cd Length: 457  Bit Score: 263.78  E-value: 2.06e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVT 606
Cdd:cd07090     3 EPAT-GEVLATVHCAGAEDVDLAVKSAKAAQKEWSATSGMERGRILRKAADLLRERNDEIARLETIDNGKPIEEARVDID 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  607 EAIDFLEYYARemirlgsprSMGKVAGETNQ-----YFY---EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPS 678
Cdd:cd07090    82 SSADCLEYYAG---------LAPTLSGEHVPlpggsFAYtrrEPLGVCAGIGAWNYPIQIASWKSAPALACGNAMVYKPS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  679 GLTSIIGWQLVDIFREVGLPDGVFNFVPGrSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEM 758
Cdd:cd07090   153 PFTPLTALLLAEILTEAGLPDGVFNVVQG-GGETGQLLCEHPDVAKVSFTGSVPTGKKVMSAAAK------GIKHVTLEL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  759 GGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENA 838
Cdd:cd07090   226 GGKSPLIIFDDADLENAVNGAMMANFLSQGQVCSNGTRVFVQRSIKDEFTERLVERTKKIRIGDPLDEDTQMGALISEEH 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  839 QKRIMNYIEVGRQEG-RLLYQGHVPEV------GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTR 911
Cdd:cd07090   306 LEKVLGYIESAKQEGaKVLCGGERVVPedglenGFYVSPCVLTDCTDDMTIVREEIFGPVMSILPFDTEEEVIRRANDTT 385
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 221564986  912 YALTGGLFSR--SPEHIAIAtkRFRVGNLYLNR-NCTGALVgrqPFGGFRLSGAGTKAG 967
Cdd:cd07090   386 YGLAAGVFTRdlQRAHRVIA--QLQAGTCWINTyNISPVEV---PFGGYKQSGFGRENG 439
ALDH_LactADH_F420-Bios cd07145
Methanocaldococcus jannaschii NAD+-dependent lactaldehyde dehydrogenase-like; NAD+-dependent, ...
526-963 2.66e-78

Methanocaldococcus jannaschii NAD+-dependent lactaldehyde dehydrogenase-like; NAD+-dependent, lactaldehyde dehydrogenase (EC=1.2.1.22) involved the biosynthesis of coenzyme F(420) in Methanocaldococcus jannaschii through the oxidation of lactaldehyde to lactate and generation of NAPH, and similar sequences are included in this CD.


Pssm-ID: 143463 [Multi-domain]  Cd Length: 456  Bit Score: 263.44  E-value: 2.66e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  526 MNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADV 605
Cdd:cd07145     4 RNPAN-GEVIDTVPSLSREEVREAIEVAEKAKDVMSNLPAYKRYKILMKVAELIERRKEELAKLLTIEVGKPIKQSRVEV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  606 TEAIDFLEYYAREmirlgSPRSMGKV----AGETNQYFY-----EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFK 676
Cdd:cd07145    83 ERTIRLFKLAAEE-----AKVLRGETipvdAYEYNERRIaftvrEPIGVVGAITPFNFPANLFAHKIAPAIAVGNSVVVK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  677 PSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVIC 756
Cdd:cd07145   158 PSSNTPLTAIELAKILEEAGLPPGVINVVTGYGSEVGDEIVTNPKVNMISFTGSTAVGLLIASKAGG------TGKKVAL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  757 EMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVG-PVEDPAN---LIGA 832
Cdd:cd07145   232 ELGGSDPMIVLKDADLERAVSIAVRGRFENAGQVCNAVKRILVEEEVYDKFLKLLVEKVKKLKVGdPLDESTDlgpLISP 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  833 VAEENAQKRIMNYIEVGrqeGRLLYQGHVPEvGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRY 912
Cdd:cd07145   312 EAVERMENLVNDAVEKG---GKILYGGKRDE-GSFFPPTVLENDTPDMIVMKEEVFGPVLPIAKVKDDEEAVEIANSTEY 387
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 221564986  913 ALTGGLFSrspEHIAIATK---RFRVGNLYLNrNCTGALVGRQPFGGFRLSGAG 963
Cdd:cd07145   388 GLQASVFT---NDINRALKvarELEAGGVVIN-DSTRFRWDNLPFGGFKKSGIG 437
PLN02467 PLN02467
betaine aldehyde dehydrogenase
510-974 4.09e-78

betaine aldehyde dehydrogenase


Pssm-ID: 215260 [Multi-domain]  Cd Length: 503  Bit Score: 264.67  E-value: 4.09e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQELE--TEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFET-----WRDITPEIRAEFLLKACTVVRRR 582
Cdd:PLN02467   10 LFIGGEWREpvLGKRIPVVNPAT-EETIGDIPAATAEDVDAAVEAARKAFKRnkgkdWARTTGAVRAKYLRAIAAKITER 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  583 IYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAR--EMI--RLGSPRSMGKVAGETNqYFYEPKGVAAVIAPWNFPLAI 658
Cdd:PLN02467   89 KSELAKLETLDCGKPLDEAAWDMDDVAGCFEYYADlaEALdaKQKAPVSLPMETFKGY-VLKEPLGVVGLITPWNYPLLM 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  659 SMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRII 738
Cdd:PLN02467  168 ATWKVAPALAAGCTAVLKPSELASVTCLELADICREVGLPPGVLNVVTGLGTEAGAPLASHPGVDKIAFTGSTATGRKIM 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  739 ERAAkvqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAV 818
Cdd:PLN02467  248 TAAA------QMVKPVSLELGGKSPIIVFDDVDLDKAVEWAMFGCFWTNGQICSATSRLLVHERIASEFLEKLVKWAKNI 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  819 PVG-PVEDPANLiGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEV---GFFVPLTIIGDIRPEHRLAQEEIFGPLLA 893
Cdd:PLN02467  322 KISdPLEEGCRL-GPVVSEGQYEKVLKFISTAKSEGaTILCGGKRPEHlkkGFFIEPTIITDVTTSMQIWREEVFGPVLC 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  894 VMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGTKAG--GPDY 971
Cdd:PLN02467  401 VKTFSTEDEAIELANDSHYGLAGAVISNDLERCERVSEAFQAGIVWI--NCSQPCFCQAPWGGIKRSGFGRELGewGLEN 478

                  ...
gi 221564986  972 LLH 974
Cdd:PLN02467  479 YLS 481
ALDH_ACDHII_AcoD-like cd07559
Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus ...
508-963 8.28e-78

Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane, as well as, the uncharacterized aldehyde dehydrogenase from Staphylococcus aureus (AldA1, locus SACOL0154) and other similar sequences.


Pssm-ID: 143471 [Multi-domain]  Cd Length: 480  Bit Score: 263.05  E-value: 8.28e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  508 YPLFIGGQELETED--LLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:cd07559     1 YDNFINGEWVAPSKgeYFDNYNPVN-GKVLCEIPRSTAEDVDLAVDAAHEAFKTWGKTSVAERANILNKIADRIEENLEL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  586 LSALQVLEIGKQWDQAY-ADVTEAIDFLEYYArEMIRLGSPrSMGKVAGET-NQYFYEPKGVAAVIAPWNFPLAISMGMV 663
Cdd:cd07559    80 LAVAETLDNGKPIRETLaADIPLAIDHFRYFA-GVIRAQEG-SLSEIDEDTlSYHFHEPLGVVGQIIPWNFPLLMAAWKL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  664 SAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVgLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAk 743
Cdd:cd07559   158 APALAAGNTVVLKPASQTPLSILVLMELIGDL-LPKGVVNVVTGFGSEAGKPLASHPRIAKLAFTGSTTVGRLIMQYAA- 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  744 vqpgqEMVKKVICEMGGK--NAIIIDDDADLDEAVPHVFNSAFGF---QGQKCSACSRVIVLDGIYDKFVQRLTALAEAV 818
Cdd:cd07559   236 -----ENLIPVTLELGGKspNIFFDDAMDADDDFDDKAEEGQLGFafnQGEVCTCPSRALVQESIYDEFIERAVERFEAI 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  819 PVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGH-----VPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLL 892
Cdd:cd07559   311 KVGNPLDPETMMGAQVSKDQLEKILSYVDIGKEEGaEVLTGGErltlgGLDKGYFYEPTLIKGGNNDMRIFQEEIFGPVL 390
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221564986  893 AVMRARDFNEALVWANSTRYALTGGLFSRSpehiaiATKRFRVGN-LYLNR---NCTGALVGRQPFGGFRLSGAG 963
Cdd:cd07559   391 AVITFKDEEEAIAIANDTEYGLGGGVWTRD------INRALRVARgIQTGRvwvNCYHQYPAHAPFGGYKKSGIG 459
PRK13252 PRK13252
betaine aldehyde dehydrogenase; Provisional
507-963 3.58e-77

betaine aldehyde dehydrogenase; Provisional


Pssm-ID: 183918  Cd Length: 488  Bit Score: 261.35  E-value: 3.58e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  507 KYPLFIGGQELE--TEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIY 584
Cdd:PRK13252    6 LQSLYIDGAYVEatSGETFEVINPAT-GEVLATVQAATPADVEAAVASAKQGQKIWAAMTAMERSRILRRAVDILRERND 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  585 ELSALQVLEIGKQWDQA-YADVTEAIDFLEYYAR-------EMIRLGSprsmgkvagetNQYFY---EPKGVAAVIAPWN 653
Cdd:PRK13252   85 ELAALETLDTGKPIQETsVVDIVTGADVLEYYAGlapalegEQIPLRG-----------GSFVYtrrEPLGVCAGIGAWN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  654 FPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGrSGIMGDYLVDHPHVSLIAFTGSMEV 733
Cdd:PRK13252  154 YPIQIACWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYTEAGLPDGVFNVVQG-DGRVGAWLTEHPDIAKVSFTGGVPT 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  734 GLRIIERAAkvqpgqEMVKKVICEMGGKNAIIidddadldeavphVFNSA-------------FGFQGQKCSACSRVIVL 800
Cdd:PRK13252  233 GKKVMAAAA------ASLKEVTMELGGKSPLI-------------VFDDAdldraadiamlanFYSSGQVCTNGTRVFVQ 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  801 DGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGH-----VPEVGFFVPLTIIG 874
Cdd:PRK13252  294 KSIKAAFEARLLERVERIRIGDPMDPATNFGPLVSFAHRDKVLGYIEKGKAEGaRLLCGGErltegGFANGAFVAPTVFT 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  875 DIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSR--SPEHIAIAtkRFRVGNLYLnrNCTGALVGRQ 952
Cdd:PRK13252  374 DCTDDMTIVREEIFGPVMSVLTFDDEDEVIARANDTEYGLAAGVFTAdlSRAHRVIH--QLEAGICWI--NTWGESPAEM 449
                         490
                  ....*....|.
gi 221564986  953 PFGGFRLSGAG 963
Cdd:PRK13252  450 PVGGYKQSGIG 460
ALDH_F11_NP-GAPDH cd07082
NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family ...
507-964 1.44e-75

NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase (NP-GAPDH, EC=1.2.1.9) catalyzes the irreversible oxidation of glyceraldehyde 3-phosphate to 3-phosphoglycerate generating NADPH for biosynthetic reactions. This CD also includes the Arabidopsis thaliana osmotic-stress-inducible ALDH family 11, ALDH11A3 and similar sequences. In autotrophic eukaryotes, NP-GAPDH generates NADPH for biosynthetic processes from photosynthetic glyceraldehyde-3-phosphate exported from the chloroplast and catalyzes one of the classic glycolytic bypass reactions unique to plants.


Pssm-ID: 143401 [Multi-domain]  Cd Length: 473  Bit Score: 256.34  E-value: 1.44e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  507 KYPLFIGGQELETE-DLLPSMNPSDPsEIVGWVCQAGTDEVAQAIGAARKSFE-TWRDITPEIRAEFLLKACTVVRRRIY 584
Cdd:cd07082     1 QFKYLINGEWKESSgKTIEVYSPIDG-EVIGSVPALSALEILEAAETAYDAGRgWWPTMPLEERIDCLHKFADLLKENKE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  585 ELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRL--------GSPRSMGKVAgetnQYFYEPKGVAAVIAPWNFPL 656
Cdd:cd07082    80 EVANLLMWEIGKTLKDALKEVDRTIDYIRDTIEELKRLdgdslpgdWFPGTKGKIA----QVRREPLGVVLAIGPFNYPL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  657 AISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLR 736
Cdd:cd07082   156 NLTVSKLIPALIMGNTVVFKPATQGVLLGIPLAEAFHDAGFPKGVVNVVTGRGREIGDPLVTHGRIDVISFTGSTEVGNR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  737 IIERAAkvqpgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAE 816
Cdd:cd07082   236 LKKQHP--------MKRLVLELGGKDPAIVLPDADLELAAKEIVKGALSYSGQRCTAIKRVLVHESVADELVELLKEEVA 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  817 AVPVGPVEDPANLIGAVAEENA----QKRIMNYIEVGrqeGRLLYQGHVPEVGFFVPlTIIGDIRPEHRLAQEEIFGPLL 892
Cdd:cd07082   308 KLKVGMPWDNGVDITPLIDPKSadfvEGLIDDAVAKG---ATVLNGGGREGGNLIYP-TLLDPVTPDMRLAWEEPFGPVL 383
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221564986  893 AVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCtgalvgrQ------PFGGFRLSGAGT 964
Cdd:cd07082   384 PIIRVNDIEEAIELANKSNYGLQASIFTKDINKARKLADALEVGTVNINSKC-------QrgpdhfPFLGRKDSGIGT 454
ALDH_DDALDH cd07099
Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; The 4,4 ...
526-982 4.49e-75

Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; The 4,4'-diapolycopene-dialdehyde dehydrogenase (DDALDH) involved in C30 carotenoid synthesis in Methylomonas sp. strain 16a and other similar sequences are present in this CD. DDALDH converts 4,4'-diapolycopene-dialdehyde into 4,4'-diapolycopene-diacid.


Pssm-ID: 143417 [Multi-domain]  Cd Length: 453  Bit Score: 254.45  E-value: 4.49e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  526 MNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKactvVRRRIY----ELSALQVLEIGKQWDQA 601
Cdd:cd07099     1 RNPAT-GEVLGEVPVTDPAEVAAAVARARAAQRAWAALGVEGRAQRLLR----WKRALAdhadELAELLHAETGKPRADA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  602 YADVTEAIDFLEYYAREMIRLGSPRSMG---KVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPS 678
Cdd:cd07099    76 GLEVLLALEAIDWAARNAPRVLAPRKVPtglLMPNKKATVEYRPYGVVGVISPWNYPLLTPMGDIIPALAAGNAVVLKPS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  679 GLTSIIGWQLVDIFREVGLPDGVFNFVPGrSGIMGDYLVDHPhVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKKVICEM 758
Cdd:cd07099   156 EVTPLVGELLAEAWAAAGPPQGVLQVVTG-DGATGAALIDAG-VDKVAFTGSVATGRKVMAAAA------ERLIPVVLEL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  759 GGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEEN- 837
Cdd:cd07099   228 GGKDPMIVLADADLERAAAAAVWGAMVNAGQTCISVERVYVHESVYDEFVARLVAKARALRPGADDIGDADIGPMTTARq 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  838 ---AQKRIMNYIEVGrqeGRLLYQGHVPEV-GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYA 913
Cdd:cd07099   308 ldiVRRHVDDAVAKG---AKALTGGARSNGgGPFYEPTVLTDVPHDMDVMREETFGPVLPVMPVADEDEAIALANDSRYG 384
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  914 LTGGLFSRSPEHI-AIATkRFRVGNLYLNRNCTGALVGRQPFGGFRLSGAGTKaGGPDYLLHFMDPRVVT 982
Cdd:cd07099   385 LSASVFSRDLARAeAIAR-RLEAGAVSINDVLLTAGIPALPFGGVKDSGGGRR-HGAEGLREFCRPKAIA 452
ALDH_F1AB_F2_RALDH1 cd07141
NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like; NAD+-dependent ...
524-967 1.52e-74

NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like; NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36) also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1) in humans, is a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism.


Pssm-ID: 143459  Cd Length: 481  Bit Score: 253.81  E-value: 1.52e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  524 PSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFE---TWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQW-D 599
Cdd:cd07141    25 PTINPAT-GEKICEVQEGDKADVDKAVKAARAAFKlgsPWRTMDASERGRLLNKLADLIERDRAYLASLETLDNGKPFsK 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  600 QAYADVTEAIDFLEYYAremirlgsprsmG---KVAGET----NQYF----YEPKGVAAVIAPWNFPLAISMGMVSAAIV 668
Cdd:cd07141   104 SYLVDLPGAIKVLRYYA------------GwadKIHGKTipmdGDFFtytrHEPVGVCGQIIPWNFPLLMAAWKLAPALA 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  669 TGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGlRIIERAAkvqpGQ 748
Cdd:cd07141   172 CGNTVVLKPAEQTPLTALYLASLIKEAGFPPGVVNVVPGYGPTAGAAISSHPDIDKVAFTGSTEVG-KLIQQAA----GK 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  749 EMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPAN 828
Cdd:cd07141   247 SNLKRVTLELGGKSPNIVFADADLDYAVEQAHEALFFNMGQCCCAGSRTFVQESIYDEFVKRSVERAKKRVVGNPFDPKT 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  829 LIGAVAEENAQKRIMNYIEVGRQEGRLLYQG--HVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVW 906
Cdd:cd07141   327 EQGPQIDEEQFKKILELIESGKKEGAKLECGgkRHGDKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIFKFKTIDEVIER 406
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221564986  907 ANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGTKAG 967
Cdd:cd07141   407 ANNTTYGLAAAVFTKDIDKAITFSNALRAGTVWV--NCYNVVSPQAPFGGYKMSGNGRELG 465
ALDH_AldA_AN0554 cd07143
Aspergillus nidulans aldehyde dehydrogenase, AldA (AN0554)-like; NAD(P)+-dependent aldehyde ...
510-974 7.18e-74

Aspergillus nidulans aldehyde dehydrogenase, AldA (AN0554)-like; NAD(P)+-dependent aldehyde dehydrogenase (AldA) of Aspergillus nidulans (locus AN0554), and other similar sequences, are present in this CD.


Pssm-ID: 143461  Cd Length: 481  Bit Score: 252.06  E-value: 7.18e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQELETED--LLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFET-W-RDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:cd07143     9 LFINGEFVDSVHggTVKVYNPST-GKLITKIAEATEADVDIAVEVAHAAFETdWgLKVSGSKRGRCLSKLADLMERNLDY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  586 LSALQVLEIGKQWDQAYA-DVTEAIDFLEYYAremirlG-SPRSMGKVAgETNQ-----YFYEPKGVAAVIAPWNFPLAI 658
Cdd:cd07143    88 LASIEALDNGKTFGTAKRvDVQASADTFRYYG------GwADKIHGQVI-ETDIkkltyTRHEPIGVCGQIIPWNFPLLM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  659 SMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRII 738
Cdd:cd07143   161 CAWKIAPALAAGNTIVLKPSELTPLSALYMTKLIPEAGFPPGVINVVSGYGRTCGNAISSHMDIDKVAFTGSTLVGRKVM 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  739 ERAAKVQpgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAV 818
Cdd:cd07143   241 EAAAKSN-----LKKVTLELGGKSPNIVFDDADLESAVVWTAYGIFFNHGQVCCAGSRIYVQEGIYDKFVKRFKEKAKKL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  819 PVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQG---HVPEvGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVM 895
Cdd:cd07143   316 KVGDPFAEDTFQGPQVSQIQYERIMSYIESGKAEGATVETGgkrHGNE-GYFIEPTIFTDVTEDMKIVKEEIFGPVVAVI 394
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221564986  896 RARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGTKAGgpDYLLH 974
Cdd:cd07143   395 KFKTEEEAIKRANDSTYGLAAAVFTNNINNAIRVANALKAGTVWV--NCYNLLHHQVPFGGYKQSGIGRELG--EYALE 469
ALDH_F16 cd07111
Aldehyde dehydrogenase family 16A1-like; Uncharacterized aldehyde dehydrogenase family 16 ...
505-978 1.47e-73

Aldehyde dehydrogenase family 16A1-like; Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.


Pssm-ID: 143429 [Multi-domain]  Cd Length: 480  Bit Score: 251.16  E-value: 1.47e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  505 GRKYPLFIGGQELETED--LLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRR 582
Cdd:cd07111    19 DRSFGHFINGKWVKPENrkSFPTINPAT-GEVLASVLQAEEEDVDAAVAAARTAFESWSALPGHVRARHLYRIARHIQKH 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  583 IYELSALQVLEIGKQWDQAY-ADVTEAIDFLEYYAremirlGSPRSMgkvagETNQYFYEPKGVAAVIAPWNFPLAISMG 661
Cdd:cd07111    98 QRLFAVLESLDNGKPIRESRdCDIPLVARHFYHHA------GWAQLL-----DTELAGWKPVGVVGQIVPWNFPLLMLAW 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  662 MVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGrSGIMGDYLVDHPHVSLIAFTGSMEVGlRIIERA 741
Cdd:cd07111   167 KICPALAMGNTVVLKPAEYTPLTALLFAEICAEAGLPPGVLNIVTG-NGSFGSALANHPGVDKVAFTGSTEVG-RALRRA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  742 AKvqpGQemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVG 821
Cdd:cd07111   245 TA---GT--GKKLSLELGGKSPFIVFDDADLDSAVEGIVDAIWFNQGQVCCAGSRLLVQESVAEELIRKLKERMSHLRVG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  822 PVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQ--GHVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARD 899
Cdd:cd07111   320 DPLDKAIDMGAIVDPAQLKRIRELVEEGRAEGADVFQpgADLPSKGPFYPPTLFTNVPPASRIAQEEIFGPVLVVLTFRT 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  900 FNEALVWANSTRYALTGGLFSrspEHIAIATK---RFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGtKAGGPDYLLHFM 976
Cdd:cd07111   400 AKEAVALANNTPYGLAASVWS---ENLSLALEvalSLKAGVVWI--NGHNLFDAAAGFGGYRESGFG-REGGKEGLYEYL 473

                  ..
gi 221564986  977 DP 978
Cdd:cd07111   474 RP 475
ALDH_F2BC cd07142
Arabidosis aldehyde dehydrogenase family 2 B4, B7, C4-like; Included in this CD is the ...
510-967 2.90e-73

Arabidosis aldehyde dehydrogenase family 2 B4, B7, C4-like; Included in this CD is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial homotetramers that oxidize acetaldehyde and glycolaldehyde, but not L-lactaldehyde. Also in this group, is the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde.


Pssm-ID: 143460  Cd Length: 476  Bit Score: 250.10  E-value: 2.90e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQELETED--LLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFE--TWRDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:cd07142     6 LFINGQFVDAASgkTFPTIDPRN-GEVIAHVAEGDAEDVDRAVKAARKAFDegPWPRMTGYERSRILLRFADLLEKHADE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  586 LSALQVLEIGKQWDQA-YADVTEAIDFLEYYARemirlgsprSMGKVAGET--------NQYFYEPKGVAAVIAPWNFPL 656
Cdd:cd07142    85 LAALETWDNGKPYEQArYAEVPLAARLFRYYAG---------WADKIHGMTlpadgphhVYTLHEPIGVVGQIIPWNFPL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  657 AISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLR 736
Cdd:cd07142   156 LMFAWKVGPALACGNTIVLKPAEQTPLSALLAAKLAAEAGLPDGVLNIVTGFGPTAGAAIASHMDVDKVAFTGSTEVGKI 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  737 IIERAAKVQpgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAE 816
Cdd:cd07142   236 IMQLAAKSN-----LKPVTLELGGKSPFIVCEDADVDKAVELAHFALFFNQGQCCCAGSRTFVHESIYDEFVEKAKARAL 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  817 AVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQG--HVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAV 894
Cdd:cd07142   311 KRVVGDPFRKGVEQGPQVDKEQFEKILSYIEHGKEEGATLITGgdRIGSKGYYIQPTIFSDVKDDMKIARDEIFGPVQSI 390
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221564986  895 MRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGTKAG 967
Cdd:cd07142   391 LKFKTVDEVIKRANNSKYGLAAGVFSKNIDTANTLSRALKAGTVWV--NCYDVFDASIPFGGYKMSGIGREKG 461
ALDH_StaphAldA1 cd07117
Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; ...
508-963 6.30e-73

Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Uncharacterized aldehyde dehydrogenase from Staphylococcus aureus (AldA1, locus SACOL0154) and other similar sequences are present in this CD.


Pssm-ID: 143435  Cd Length: 475  Bit Score: 249.29  E-value: 6.30e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  508 YPLFIGGQELETE--DLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:cd07117     1 YGLFINGEWVKGSsgETIDSYNPAN-GETLSEITDATDADVDRAVKAAQEAFKTWRKTTVAERANILNKIADIIDENKEL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  586 LSALQVLEIGKQWDQAYA-DVTEAIDFLEYYArEMIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVS 664
Cdd:cd07117    80 LAMVETLDNGKPIRETRAvDIPLAADHFRYFA-GVIRAEEGSANMIDEDTLSIVLREPIGVVGQIIPWNFPFLMAAWKLA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  665 AAIVTGNCVVFKPSGLTSIIGWQLVDIFREVgLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKv 744
Cdd:cd07117   159 PALAAGNTVVIKPSSTTSLSLLELAKIIQDV-LPKGVVNIVTGKGSKSGEYLLNHPGLDKLAFTGSTEVGRDVAIAAAK- 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  745 qpgqemvkKVI---CEMGGKNAIIIDDDADLDEAVPHV-----FNsafgfQGQKCSACSRVIVLDGIYDKFVQRLTALAE 816
Cdd:cd07117   237 --------KLIpatLELGGKSANIIFDDANWDKALEGAqlgilFN-----QGQVCCAGSRIFVQEGIYDEFVAKLKEKFE 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  817 AVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGH-----VPEVGFFVPLTIIGDIRPEHRLAQEEIFGP 890
Cdd:cd07117   304 NVKVGNPLDPDTQMGAQVNKDQLDKILSYVDIAKEEGaKILTGGHrltenGLDKGFFIEPTLIVNVTNDMRVAQEEIFGP 383
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221564986  891 LLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAG 963
Cdd:cd07117   384 VATVIKFKTEDEVIDMANDSEYGLGGGVFTKDINRALRVARAVETGRVWV--NTYNQIPAGAPFGGYKKSGIG 454
ALDH_MGR_2402 cd07108
Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; NAD(P)+-dependent ...
527-982 8.78e-72

Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; NAD(P)+-dependent aldehyde dehydrogenase of Magnetospirillum gryphiswaldense MSR-1 (MGR_2402) , and other similar sequences, are present in this CD.


Pssm-ID: 143426  Cd Length: 457  Bit Score: 245.73  E-value: 8.78e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQW-DQAYADV 605
Cdd:cd07108     3 NPAT-GQVIGEVPRSRAADVDRAVAAAKAAFPEWAATPARERGKLLARIADALEARSEELARLLALETGNALrTQARPEA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  606 TEAIDFLEYYARemirLGsprsmGKVAGET-----NQYFY---EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKP 677
Cdd:cd07108    82 AVLADLFRYFGG----LA-----GELKGETlpfgpDVLTYtvrEPLGVVGAILPWNAPLMLAALKIAPALVAGNTVVLKA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  678 SGLTSIIGWQLVDIFREVgLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGlRIIERAA--KVQPgqemvkkVI 755
Cdd:cd07108   153 AEDAPLAVLLLAEILAQV-LPAGVLNVITGYGEECGAALVDHPDVDKVTFTGSTEVG-KIIYRAAadRLIP-------VS 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  756 CEMGGKNAIIIDDDADLDEAVPHVFNSA-FGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVA 834
Cdd:cd07108   224 LELGGKSPMIVFPDADLDDAVDGAIAGMrFTRQGQSCTAGSRLFVHEDIYDAFLEKLVAKLSKLKIGDPLDEATDIGAII 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  835 EENAQKRIMNYIEVGR--QEGRLLYQGHVPEV-----GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWA 907
Cdd:cd07108   304 SEKQFAKVCGYIDLGLstSGATVLRGGPLPGEgpladGFFVQPTIFSGVDNEWRLAREEIFGPVLCAIPWKDEDEVIAMA 383
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221564986  908 NSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNcTGALVGrQPFGGFRLSGAGTKAGGPDYLLHFMDPRVVT 982
Cdd:cd07108   384 NDSHYGLAAYVWTRDLGRALRAAHALEAGWVQVNQG-GGQQPG-QSYGGFKQSGLGREASLEGMLEHFTQKKTVN 456
PRK13473 PRK13473
aminobutyraldehyde dehydrogenase;
508-963 1.12e-71

aminobutyraldehyde dehydrogenase;


Pssm-ID: 237391  Cd Length: 475  Bit Score: 245.97  E-value: 1.12e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  508 YPLFIGGQELETE-DLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYEL 586
Cdd:PRK13473    3 TKLLINGELVAGEgEKQPVYNPAT-GEVLAEIAEASAAQVDAAVAAADAAFPEWSQTTPKERAEALLKLADAIEENADEF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  587 SALQVLEIGKQWDQAYAD-VTEAIDFLEYYAremirlGSPRSM-GKVAGE-----TNQYFYEPKGVAAVIAPWNFPLAIS 659
Cdd:PRK13473   82 ARLESLNCGKPLHLALNDeIPAIVDVFRFFA------GAARCLeGKAAGEyleghTSMIRRDPVGVVASIAPWNYPLMMA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  660 MGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVgLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIE 739
Cdd:PRK13473  156 AWKLAPALAAGNTVVLKPSEITPLTALKLAELAADI-LPPGVLNVVTGRGATVGDALVGHPKVRMVSLTGSIATGKHVLS 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  740 RAAKvqpgqeMVKKVICEMGGKnaiiidddadldeaVPH-VFNSA-----------FGF--QGQKCSACSRVIVLDGIYD 805
Cdd:PRK13473  235 AAAD------SVKRTHLELGGK--------------APViVFDDAdldavvegirtFGYynAGQDCTAACRIYAQRGIYD 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  806 KFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG--RLLYQGHVPEV-GFFVPLTIIGDIRPEHRL 882
Cdd:PRK13473  295 DLVAKLAAAVATLKVGDPDDEDTELGPLISAAHRDRVAGFVERAKALGhiRVVTGGEAPDGkGYYYEPTLLAGARQDDEI 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  883 AQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGA 962
Cdd:PRK13473  375 VQREVFGPVVSVTPFDDEDQAVRWANDSDYGLASSVWTRDVGRAHRVSARLQYGCTWV--NTHFMLVSEMPHGGQKQSGY 452

                  .
gi 221564986  963 G 963
Cdd:PRK13473  453 G 453
ALDH_PsfA-ACA09737 cd07120
Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Included in this CD is the ...
525-982 1.52e-70

Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Included in this CD is the aldehyde dehydrogenase (PsfA, locus ACA09737) of Pseudomonas putida involved in furoic acid metabolism. Transcription of psfA was induced in response to 2-furoic acid, furfuryl alcohol, and furfural.


Pssm-ID: 143438 [Multi-domain]  Cd Length: 455  Bit Score: 242.25  E-value: 1.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  525 SMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFE--TWRDiTPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAY 602
Cdd:cd07120     1 SIDPAT-GEVIGTYADGGVAEAEAAIAAARRAFDetDWAH-DPRLRARVLLELADAFEANAERLARLLALENGKILGEAR 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  603 ADVTEAIDFLEYYArEMIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTS 682
Cdd:cd07120    79 FEISGAISELRYYA-GLARTEAGRMIEPEPGSFSLVLREPMGVAGIIVPWNSPVVLLVRSLAPALAAGCTVVVKPAGQTA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  683 IIGWQLVDIFREV-GLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGK 761
Cdd:cd07120   158 QINAAIIRILAEIpSLPAGVVNLFTESGSEGAAHLVASPDVDVISFTGSTATGRAIMAAAAP------TLKRLGLELGGK 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  762 NAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKR 841
Cdd:cd07120   232 TPCIVFDDADLDAALPKLERALTIFAGQFCMAGSRVLVQRSIADEVRDRLAARLAAVKVGPGLDPASDMGPLIDRANVDR 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  842 IMNYIEVGRQEGR--LLYQGHVPEV---GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTG 916
Cdd:cd07120   312 VDRMVERAIAAGAevVLRGGPVTEGlakGAFLRPTLLEVDDPDADIVQEEIFGPVLTLETFDDEAEAVALANDTDYGLAA 391
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221564986  917 GLFSRSPEHIAIATKRFRVGNLYLNRNctGALVGRQPFGGFRLSGAGtKAGGPDYLLHFMDPRVVT 982
Cdd:cd07120   392 SVWTRDLARAMRVARAIRAGTVWINDW--NKLFAEAEEGGYRQSGLG-RLHGVAALEDFIEYKHIY 454
ALDH_SGSD_AstD cd07095
N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; N-succinylglutamate ...
545-961 1.27e-68

N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; N-succinylglutamate 5-semialdehyde dehydrogenase or succinylglutamic semialdehyde dehydrogenase (SGSD, E. coli AstD, EC=1.2.1.71) involved in L-arginine degradation via the arginine succinyltransferase (AST) pathway and catalyzes the NAD+-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.


Pssm-ID: 143414 [Multi-domain]  Cd Length: 431  Bit Score: 236.01  E-value: 1.27e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  545 EVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQ-WDQAyadvTEA------IDFLEYYAR 617
Cdd:cd07095     1 QVDAAVAAARAAFPGWAALSLEERAAILRRFAELLKANKEELARLISRETGKPlWEAQ----TEVaamagkIDISIKAYH 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  618 EmiRLGSPR-SMGKVAGETNqyfYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVG 696
Cdd:cd07095    77 E--RTGERAtPMAQGRAVLR---HRPHGVMAVFGPFNFPGHLPNGHIVPALLAGNTVVFKPSELTPAVAELMVELWEEAG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  697 LPDGVFNFVPGrSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvQPGqemvKKVICEMGGKNAIIIDDDADLDEAV 776
Cdd:cd07095   152 LPPGVLNLVQG-GRETGEALAAHEGIDGLLFTGSAATGLLLHRQFAG-RPG----KILALEMGGNNPLVVWDVADIDAAA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  777 PHVFNSAFGFQGQKCSACSRVIVLDGIY-DKFVQRLTALAEAVPVG-PVEDPANLIGAVAEENAQKRIMNYIEVGRQEGR 854
Cdd:cd07095   226 YLIVQSAFLTAGQRCTCARRLIVPDGAVgDAFLERLVEAAKRLRIGaPDAEPPFMGPLIIAAAAARYLLAQQDLLALGGE 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  855 LLYQGH-VPEVGFFVPLTIIgDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRF 933
Cdd:cd07095   306 PLLAMErLVAGTAFLSPGII-DVTDAADVPDEEIFGPLLQVYRYDDFDEAIALANATRFGLSAGLLSDDEALFERFLARI 384
                         410       420
                  ....*....|....*....|....*...
gi 221564986  934 RVGNLYLNRNCTGAlVGRQPFGGFRLSG 961
Cdd:cd07095   385 RAGIVNWNRPTTGA-SSTAPFGGVGLSG 411
ALDH_BenzADH cd07152
NAD-dependent benzaldehyde dehydrogenase II-like; NAD-dependent, benzaldehyde dehydrogenase II ...
533-982 8.95e-67

NAD-dependent benzaldehyde dehydrogenase II-like; NAD-dependent, benzaldehyde dehydrogenase II (XylC, BenzADH, EC=1.2.1.28) is involved in the oxidation of benzyl alcohol to benzoate. In Acinetobacter calcoaceticus, this process is carried out by the chromosomally encoded, benzyl alcohol dehydrogenase (xylB) and benzaldehyde dehydrogenase II (xylC) enzymes; whereas in Pseudomonas putida they are encoded by TOL plasmids.


Pssm-ID: 143470 [Multi-domain]  Cd Length: 443  Bit Score: 231.03  E-value: 8.95e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  533 EIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFL 612
Cdd:cd07152     2 AVLGEVGVADAADVDRAAARAAAAQRAWAATPPRERAAVLRRAADLLEEHADEIADWIVRESGSIRPKAGFEVGAAIGEL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  613 eyyaREMIRLGSpRSMGKV----AGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQL 688
Cdd:cd07152    82 ----HEAAGLPT-QPQGEIlpsaPGRLSLARRVPLGVVGVISPFNFPLILAMRSVAPALALGNAVVLKPDPRTPVSGGVV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  689 V-DIFREVGLPDGVFNFVPGRSGImGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNAIIID 767
Cdd:cd07152   157 IaRLFEEAGLPAGVLHVLPGGADA-GEALVEDPNVAMISFTGSTAVGRKVGEAAGR------HLKKVSLELGGKNALIVL 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  768 DDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVG-PVEDPANLiGAVAEENAQKRIMNYI 846
Cdd:cd07152   230 DDADLDLAASNGAWGAFLHQGQICMAAGRHLVHESVADAYTAKLAAKAKHLPVGdPATGQVAL-GPLINARQLDRVHAIV 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  847 EVGRQEGRLLYQGHVPEVGFFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHI 926
Cdd:cd07152   309 DDSVAAGARLEAGGTYDGLFYRP-TVLSGVKPGMPAFDEEIFGPVAPVTVFDSDEEAVALANDTEYGLSAGIISRDVGRA 387
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 221564986  927 AIATKRFRVGNLYLNrNCTGALVGRQPFGGFRLSGAGTKAGGPDYLLHFMDPRVVT 982
Cdd:cd07152   388 MALADRLRTGMLHIN-DQTVNDEPHNPFGGMGASGNGSRFGGPANWEEFTQWQWVT 442
PLN02766 PLN02766
coniferyl-aldehyde dehydrogenase
530-967 9.44e-67

coniferyl-aldehyde dehydrogenase


Pssm-ID: 215410 [Multi-domain]  Cd Length: 501  Bit Score: 232.79  E-value: 9.44e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  530 DP--SEIVGWVCQAGTDEVAQAIGAARKSFE--TWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQA-YAD 604
Cdd:PLN02766   42 DPrtGEVIARIAEGDKEDVDLAVKAAREAFDhgPWPRMSGFERGRIMMKFADLIEEHIEELAALDTIDAGKLFALGkAVD 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  605 VTEAIDFLEYYA--REMIRLGSPRSMGKVAGETnqyFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTS 682
Cdd:PLN02766  122 IPAAAGLLRYYAgaADKIHGETLKMSRQLQGYT---LKEPIGVVGHIIPWNFPSTMFFMKVAPALAAGCTMVVKPAEQTP 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  683 IIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVQpgqemVKKVICEMGGKN 762
Cdd:PLN02766  199 LSALFYAHLAKLAGVPDGVINVVTGFGPTAGAAIASHMDVDKVSFTGSTEVGRKIMQAAATSN-----LKQVSLELGGKS 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  763 AIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRI 842
Cdd:PLN02766  274 PLLIFDDADVDMAVDLALLGIFYNKGEICVASSRVYVQEGIYDEFVKKLVEKAKDWVVGDPFDPRARQGPQVDKQQFEKI 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  843 MNYIEVGRQEGRLLYQGHVP--EVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFS 920
Cdd:PLN02766  354 LSYIEHGKREGATLLTGGKPcgDKGYYIEPTIFTDVTEDMKIAQDEIFGPVMSLMKFKTVEEAIKKANNTKYGLAAGIVT 433
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 221564986  921 RSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGTKAG 967
Cdd:PLN02766  434 KDLDVANTVSRSIRAGTIWV--NCYFAFDPDCPFGGYKMSGFGRDQG 478
PLN02278 PLN02278
succinic semialdehyde dehydrogenase
511-986 3.15e-66

succinic semialdehyde dehydrogenase


Pssm-ID: 215157 [Multi-domain]  Cd Length: 498  Bit Score: 231.50  E-value: 3.15e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  511 FIGGQELETED--LLPSMNPSDPSEIVGWVCQaGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSA 588
Cdd:PLN02278   28 LIGGKWTDAYDgkTFPVYNPATGEVIANVPCM-GRAETNDAIASAHDAFPSWSKLTASERSKILRRWYDLIIANKEDLAQ 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  589 LQVLEIGKQWDQAYADVTEAIDFLEYYAREMIR-----LGSPRSMGKVAGeTNQyfyePKGVAAVIAPWNFPLAISMGMV 663
Cdd:PLN02278  107 LMTLEQGKPLKEAIGEVAYGASFLEYFAEEAKRvygdiIPSPFPDRRLLV-LKQ----PVGVVGAITPWNFPLAMITRKV 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  664 SAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAK 743
Cdd:PLN02278  182 GPALAAGCTVVVKPSELTPLTALAAAELALQAGIPPGVLNVVMGDAPEIGDALLASPKVRKITFTGSTAVGKKLMAGAAA 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  744 VqpgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPV 823
Cdd:PLN02278  262 T------VKRVSLELGGNAPFIVFDDADLDVAVKGALASKFRNSGQTCVCANRILVQEGIYDKFAEAFSKAVQKLVVGDG 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  824 EDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEVG--FFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDF 900
Cdd:PLN02278  336 FEEGVTQGPLINEAAVQKVESHVQDAVSKGaKVLLGGKRHSLGgtFYEP-TVLGDVTEDMLIFREEVFGPVAPLTRFKTE 414
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  901 NEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGrqPFGGFRLSGAGtKAGGPDYLLHFMDPRV 980
Cdd:PLN02278  415 EEAIAIANDTEAGLAAYIFTRDLQRAWRVSEALEYGIVGVNEGLISTEVA--PFGGVKQSGLG-REGSKYGIDEYLEIKY 491

                  ....*.
gi 221564986  981 VTENTM 986
Cdd:PLN02278  492 VCLGNM 497
ALDH_PADH_NahF cd07113
Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; NAD+-dependent, ...
510-982 1.01e-65

Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; NAD+-dependent, homodimeric, phenylacetaldehyde dehydrogenase (PADH, EC=1.2.1.39) PadA of Escherichia coli involved in the catabolism of 2-phenylethylamine, and other related sequences, are present in this CD. Also included is the Pseudomonas fluorescens ST StyD PADH involved in styrene catabolism, the Sphingomonas sp. LB126 FldD protein involved in fluorene degradation, and the Novosphingobium aromaticivorans NahF salicylaldehyde dehydrogenase involved in the NAD+-dependent conversion of salicylaldehyde to salicylate.


Pssm-ID: 143431  Cd Length: 477  Bit Score: 229.25  E-value: 1.01e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQEL--ETEDLLPSMNPSDPSEIvGWVCQAGTDEVAQAIGAARKSFET-WRDITPEIRAEFLLKACTVVRRRIYEL 586
Cdd:cd07113     2 HFIDGRPVagQSEKRLDITNPATEQVI-ASVASATEADVDAAVASAWRAFVSaWAKTTPAERGRILLRLADLIEQHGEEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  587 SALQVLEIGKQWDQAYA-DVTEAIDFLEYYAR-------EMIRLGSPrSMGkvaGETNQYFY--EPKGVAAVIAPWNFPL 656
Cdd:cd07113    81 AQLETLCSGKSIHLSRAfEVGQSANFLRYFAGwatkingETLAPSIP-SMQ---GERYTAFTrrEPVGVVAGIVPWNFSV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  657 AISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGrSGIMGDYLVDHPHVSLIAFTGSMEVGLR 736
Cdd:cd07113   157 MIAVWKIGAALATGCTIVIKPSEFTPLTLLRVAELAKEAGIPDGVLNVVNG-KGAVGAQLISHPDVAKVSFTGSVATGKK 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  737 IIERAAkvqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAE 816
Cdd:cd07113   236 IGRQAA------SDLTRVTLELGGKNAAAFLKDADIDWVVEGLLTAGFLHQGQVCAAPERFYVHRSKFDELVTKLKQALS 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  817 AVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGH-VPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAV 894
Cdd:cd07113   310 SFQVGSPMDESVMFGPLANQPHFDKVCSYLDDARAEGdEIVRGGEaLAGEGYFVQPTLVLARSADSRLMREETFGPVVSF 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  895 MRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTgaLVGRQPFGGFRLSGAGtKAGGPDYLLH 974
Cdd:cd07113   390 VPYEDEEELIQLINDTPFGLTASVWTNNLSKALRYIPRIEAGTVWVNMHTF--LDPAVPFGGMKQSGIG-REFGSAFIDD 466

                  ....*...
gi 221564986  975 FMDPRVVT 982
Cdd:cd07113   467 YTELKSVM 474
ALDH_SaliADH cd07105
Salicylaldehyde dehydrogenase, DoxF-like; Salicylaldehyde dehydrogenase (DoxF, SaliADH, EC=1.2. ...
545-963 1.02e-64

Salicylaldehyde dehydrogenase, DoxF-like; Salicylaldehyde dehydrogenase (DoxF, SaliADH, EC=1.2.1.65) involved in the upper naphthalene catabolic pathway of Pseudomonas strain C18 and other similar sequences are present in this CD.


Pssm-ID: 143423 [Multi-domain]  Cd Length: 432  Bit Score: 225.15  E-value: 1.02e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  545 EVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYArEMIRLGS 624
Cdd:cd07105     1 DADQAVEAAAAAFPAWSKTPPSERRDILLKAADLLESRRDEFIEAMMEETGATAAWAGFNVDLAAGMLREAA-SLITQII 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  625 PRSMGKVAGETNQY-FYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFN 703
Cdd:cd07105    80 GGSIPSDKPGTLAMvVKEPVGVVLGIAPWNAPVILGTRAIAYPLAAGNTVVLKASELSPRTHWLIGRVFHEAGLPKGVLN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  704 FV---PGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNAIIIDDDADLDEAVPHVF 780
Cdd:cd07105   160 VVthsPEDAPEVVEALIAHPAVRKVNFTGSTRVGRIIAETAAK------HLKPVLLELGGKAPAIVLEDADLDAAANAAL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  781 NSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPAnLIGAVAEENAQKRIMNYIEVGrqeGRLLYQGH 860
Cdd:cd07105   234 FGAFLNSGQICMSTERIIVHESIADEFVEKLKAAAEKLFAGPVVLGS-LVSAAAADRVKELVDDALSKG---AKLVVGGL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  861 VPEV--GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEH-IAIAtKRFRVGN 937
Cdd:cd07105   310 ADESpsGTSMPPTILDNVTPDMDIYSEESFGPVVSIIRVKDEEEAVRIANDSEYGLSAAVFTRDLARaLAVA-KRIESGA 388
                         410       420
                  ....*....|....*....|....*....
gi 221564986  938 LYLNrnctGALVGRQ---PFGGFRLSGAG 963
Cdd:cd07105   389 VHIN----GMTVHDEptlPHGGVKSSGYG 413
ALDH_F21_LactADH-like cd07094
ALDH subfamily: NAD+-dependent, lactaldehyde dehydrogenase, ALDH family 21 A1, and related ...
527-963 7.48e-64

ALDH subfamily: NAD+-dependent, lactaldehyde dehydrogenase, ALDH family 21 A1, and related proteins; ALDH subfamily which includes Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123), and NAD+-dependent, lactaldehyde dehydrogenase (EC=1.2.1.22) and like sequences.


Pssm-ID: 143413 [Multi-domain]  Cd Length: 453  Bit Score: 223.46  E-value: 7.48e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVT 606
Cdd:cd07094     5 NPYD-GEVIGKVPADDRADAEEALATARAGAENRRALPPHERMAILERAADLLKKRAEEFAKIIACEGGKPIKDARVEVD 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  607 EAIDFLEYYAREMIRL-GSPRSMGKVAGETNQYFY---EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTS 682
Cdd:cd07094    84 RAIDTLRLAAEEAERIrGEEIPLDATQGSDNRLAWtirEPVGVVLAITPFNFPLNLVAHKLAPAIATGCPVVLKPASKTP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  683 IIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqemvKKVICEMGGKN 762
Cdd:cd07094   164 LSALELAKILVEAGVPEGVLQVVTGEREVLGDAFAADERVAMLSFTGSAAVGEALRANAGG--------KRIALELGGNA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  763 AIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRI 842
Cdd:cd07094   236 PVIVDRDADLDAAIEALAKGGFYHAGQVCISVQRIYVHEELYDEFIEAFVAAVKKLKVGDPLDEDTDVGPLISEEAAERV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  843 MNYIEVGRQEGRLLYQGHVPEVGFFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRS 922
Cdd:cd07094   316 ERWVEEAVEAGARLLCGGERDGALFKP-TVLEDVPRDTKLSTEETFGPVVPIIRYDDFEEAIRIANSTDYGLQAGIFTRD 394
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 221564986  923 PEHIAIATKRFRVGNLYLNrNCTGALVGRQPFGGFRLSGAG 963
Cdd:cd07094   395 LNVAFKAAEKLEVGGVMVN-DSSAFRTDWMPFGGVKESGVG 434
ALDH_F21_RNP123 cd07147
Aldehyde dehydrogenase family 21A1-like; Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) ...
523-981 9.55e-63

Aldehyde dehydrogenase family 21A1-like; Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) was first described in the moss Tortula ruralis and is believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and ALDH21A1 expression represents a unique stress tolerance mechanism. So far, of plants, only the bryophyte sequence has been observed, but similar protein sequences from bacteria and archaea are also present in this CD.


Pssm-ID: 143465 [Multi-domain]  Cd Length: 452  Bit Score: 220.19  E-value: 9.55e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  523 LPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAY 602
Cdd:cd07147     1 LEVTNPYT-GEVVARVALAGPDDIEEAIAAAVKAFRPMRALPAHRRAAILLHCVARLEERFEELAETIVLEAGKPIKDAR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  603 ADVTEAIDFLEYYAREMIRLG--------SPRSMGKVaGETNQYfyePKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVV 674
Cdd:cd07147    80 GEVARAIDTFRIAAEEATRIYgevlpldiSARGEGRQ-GLVRRF---PIGPVSAITPFNFPLNLVAHKVAPAIAAGCPFV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  675 FKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMgDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqemvKKV 754
Cdd:cd07147   156 LKPASRTPLSALILGEVLAETGLPKGAFSVLPCSRDDA-DLLVTDERIKLLSFTGSPAVGWDLKARAGK--------KKV 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  755 ICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVA 834
Cdd:cd07147   227 VLELGGNAAVIVDSDADLDFAAQRIIFGAFYQAGQSCISVQRVLVHRSVYDEFKSRLVARVKALKTGDPKDDATDVGPMI 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  835 EENAQKRIMNYIEVGRQEGRLLYQGHVPEVGFFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYAL 914
Cdd:cd07147   307 SESEAERVEGWVNEAVDAGAKLLTGGKRDGALLEP-TILEDVPPDMEVNCEEVFGPVVTVEPYDDFDEALAAVNDSKFGL 385
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221564986  915 TGGLFSRSPEHIAIATKRFRVGNLYLN-----RnctgalVGRQPFGGFRLSGAGTKagGPDYLLHFM-DPRVV 981
Cdd:cd07147   386 QAGVFTRDLEKALRAWDELEVGGVVINdvptfR------VDHMPYGGVKDSGIGRE--GVRYAIEEMtEPRLL 450
ALDH_PhpJ cd07146
Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Putative ...
527-967 8.74e-62

Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Putative phosphonoformaldehyde dehydrogenase (PhpJ), an aldehyde dehydrogenase homolog reportedly involved in the biosynthesis of phosphinothricin tripeptides in Streptomyces viridochromogenes DSM 40736, and similar sequences are included in this CD.


Pssm-ID: 143464 [Multi-domain]  Cd Length: 451  Bit Score: 217.61  E-value: 8.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETwrdITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVT 606
Cdd:cd07146     5 NPYT-GEVVGTVPAGTEEALREALALAASYRST---LTRYQRSAILNKAAALLEARREEFARLITLESGLCLKDTRYEVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  607 EAIDFLEYYAREMIRL-GSPRSMGKVAGETNQYFY---EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTS 682
Cdd:cd07146    81 RAADVLRFAAAEALRDdGESFSCDLTANGKARKIFtlrEPLGVVLAITPFNHPLNQVAHKIAPAIAANNRIVLKPSEKTP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  683 IIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqemVKKVICEMGGKN 762
Cdd:cd07146   161 LSAIYLADLLYEAGLPPDMLSVVTGEPGEIGDELITHPDVDLVTFTGGVAVGKAIAATAG--------YKRQLLELGGND 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  763 AIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRI 842
Cdd:cd07146   233 PLIVMDDADLERAATLAVAGSYANSGQRCTAVKRILVHESVADEFVDLLVEKSAALVVGDPMDPATDMGTVIDEEAAIQI 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  843 MNYIEVGRQEG-RLLYqGHVpEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSR 921
Cdd:cd07146   313 ENRVEEAIAQGaRVLL-GNQ-RQGALYAPTVLDHVPPDAELVTEETFGPVAPVIRVKDLDEAIAISNSTAYGLSSGVCTN 390
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 221564986  922 SPEHIAIATKRFRVGNLYLNrNCTGALVGRQPFGGFRLSGAGTKAG 967
Cdd:cd07146   391 DLDTIKRLVERLDVGTVNVN-EVPGFRSELSPFGGVKDSGLGGKEG 435
ABALDH TIGR03374
1-pyrroline dehydrogenase; Members of this protein family are 1-pyrroline dehydrogenase (1.5.1. ...
507-976 3.98e-61

1-pyrroline dehydrogenase; Members of this protein family are 1-pyrroline dehydrogenase (1.5.1.35), also called gamma-aminobutyraldehyde dehydrogenase. This enzyme can follow putrescine transaminase (EC 2.6.1.82) for a two-step conversion of putrescine to gamma-aminobutyric acid (GABA). The member from Escherichia coli is characterized as a homotetramer that binds one NADH per momomer. This enzyme belongs to the medium-chain aldehyde dehydrogenases, and is quite similar in sequence to the betaine aldehyde dehydrogenase (EC 1.2.1.8) family.


Pssm-ID: 132417  Cd Length: 472  Bit Score: 216.40  E-value: 3.98e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   507 KYPLFIGGQELETE-DLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:TIGR03374    1 QHKLLINGELVSGEgEKQPVYNPAT-GEVILEIAEASAEQVDAAVRAADAAFAEWGQTTPKARAECLLKLADVIEENAQV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   586 LSALQVLEIGKQWDQAYADVTEAI-DFLEYYAremirlGSPRSM-GKVAGE-----TNQYFYEPKGVAAVIAPWNFPLAI 658
Cdd:TIGR03374   80 FAELESRNCGKPLHSVFNDEIPAIvDVFRFFA------GAARCLsGLAAGEyleghTSMIRRDPLGVVASIAPWNYPLMM 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   659 SMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVgLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRII 738
Cdd:TIGR03374  154 AAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDI-FPAGVVNILFGRGKTVGDPLTGHEKVRMVSLTGSIATGEHIL 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   739 ERAAKVqpgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVfnSAFGF--QGQKCSACSRVIVLDGIYDKFVQRLTALAE 816
Cdd:TIGR03374  233 SHTAPS------IKRTHMELGGKAPVIVFDDADIDAVVEGV--RTFGFynAGQDCTAACRIYAQRGIYDTLVEKLGAAVA 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   817 AVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG--RLLYQG-HVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLA 893
Cdd:TIGR03374  305 TLKSGAPDDESTELGPLSSLAHLERVMKAVEEAKALGhiKVITGGeKRKGNGYYFAPTLLAGAKQDDAIVQKEVFGPVVS 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986   894 VMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTgaLVGRQPFGGFRLSGAGTKA---GGPD 970
Cdd:TIGR03374  385 ITSFDDEEQVVNWANDSQYGLASSVWTKDVGRAHRLSARLQYGCTWVNTHFM--LVSEMPHGGQKLSGYGKDMslyGLED 462

                   ....*...
gi 221564986   971 YLL--HFM 976
Cdd:TIGR03374  463 YTVvrHIM 470
PRK10090 PRK10090
aldehyde dehydrogenase A; Provisional
572-981 5.42e-61

aldehyde dehydrogenase A; Provisional


Pssm-ID: 182233 [Multi-domain]  Cd Length: 409  Bit Score: 213.83  E-value: 5.42e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  572 LLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYArEMIRlgspRSMGKV-----AGETNQYFYEPKGVA 646
Cdd:PRK10090    1 LRKIAAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMA-EWAR----RYEGEIiqsdrPGENILLFKRALGVT 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  647 AVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIA 726
Cdd:PRK10090   76 TGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPKGVFNLVLGRGETVGQELAGNPKVAMVS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  727 FTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDK 806
Cdd:PRK10090  156 MTGSVSAGEKIMAAAAK------NITKVCLELGGKAPAIVMDDADLDLAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQ 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  807 FVQRLTALAEAVPVG-PVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQG--HVPEVGFFVPLTIIGDIRPEHRLA 883
Cdd:PRK10090  230 FVNRLGEAMQAVQFGnPAERNDIAMGPLINAAALERVEQKVARAVEEGARVALGgkAVEGKGYYYPPTLLLDVRQEMSIM 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  884 QEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALvgrQPF-GGFRLSGA 962
Cdd:PRK10090  310 HEETFGPVLPVVAFDTLEEAIAMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAM---QGFhAGWRKSGI 386
                         410
                  ....*....|....*....
gi 221564986  963 GtKAGGPDYLLHFMDPRVV 981
Cdd:PRK10090  387 G-GADGKHGLHEYLQTQVV 404
ALDH_SSADH1_GabD1 cd07100
Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Succinate-semialdehyde ...
546-963 1.21e-60

Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Succinate-semialdehyde dehydrogenase 1 (SSADH1, GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde (SSA) to succinate. SSADH activity in Mycobacterium tuberculosis (Mtb) is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731). The Mtb GabD1 SSADH1 reportedly is an enzyme of the gamma-aminobutyrate shunt, which forms a functional link between two TCA half-cycles by converting alpha-ketoglutarate to succinate.


Pssm-ID: 143418 [Multi-domain]  Cd Length: 429  Bit Score: 213.48  E-value: 1.21e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  546 VAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSP 625
Cdd:cd07100     1 IEAALDRAHAAFLAWRKTSFAERAALLRKLADLLRERKDELARLITLEMGKPIAEARAEVEKCAWICRYYAENAEAFLAD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  626 RSMgKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVF-NF 704
Cdd:cd07100    81 EPI-ETDAGKAYVRYEPLGVVLGIMPWNFPFWQVFRFAAPNLMAGNTVLLKHASNVPGCALAIEELFREAGFPEGVFqNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  705 VPGRSGImgDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAF 784
Cdd:cd07100   160 LIDSDQV--EAIIADPRVRGVTLTGSERAGRAVAAEAGK------NLKKSVLELGGSDPFIVLDDADLDKAVKTAVKGRL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  785 GFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPE 863
Cdd:cd07100   232 QNAGQSCIAAKRFIVHEDVYDEFLEKFVEAMAALKVGDPMDEDTDLGPLARKDLRDELHEQVEEAVAAGaTLLLGGKRPD 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  864 -VGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNr 942
Cdd:cd07100   312 gPGAFYPPTVLTDVTPGMPAYDEELFGPVAAVIKVKDEEEAIALANDSPFGLGGSVFTTDLERAERVARRLEAGMVFIN- 390
                         410       420
                  ....*....|....*....|....
gi 221564986  943 nctgALVG---RQPFGGFRLSGAG 963
Cdd:cd07100   391 ----GMVKsdpRLPFGGVKRSGYG 410
ALDH_ACDHII-AcoD cd07116
Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Included in this CD is ...
508-963 9.15e-60

Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane. These proteins apparently require RpoN factors for expression.


Pssm-ID: 143434 [Multi-domain]  Cd Length: 479  Bit Score: 212.70  E-value: 9.15e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  508 YPLFIGGQELETedlLPSMNPSDPSEIVGWV-CQA---GTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRI 583
Cdd:cd07116     1 YDNFIGGEWVAP---VKGEYFDNITPVTGKVfCEVprsTAEDIELALDAAHAAKEAWGKTSVAERANILNKIADRMEANL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  584 YELSALQVLEIGKQWDQAY-ADVTEAIDFLEYYArEMIRlGSPRSMGKVAGETNQY-FYEPKGVAAVIAPWNFPLAISMG 661
Cdd:cd07116    78 EMLAVAETWDNGKPVRETLaADIPLAIDHFRYFA-GCIR-AQEGSISEIDENTVAYhFHEPLGVVGQIIPWNFPLLMATW 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  662 MVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVgLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERA 741
Cdd:cd07116   156 KLAPALAAGNCVVLKPAEQTPASILVLMELIGDL-LPPGVVNVVNGFGLEAGKPLASSKRIAKVAFTGETTTGRLIMQYA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  742 AkvqpgqEMVKKVICEMGGKNaiiidddadldeavPHVF-------NSAF------GF------QGQKCSACSRVIVLDG 802
Cdd:cd07116   235 S------ENIIPVTLELGGKS--------------PNIFfadvmdaDDAFfdkaleGFvmfalnQGEVCTCPSRALIQES 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  803 IYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQG-------HVPEVGFFVPLTIIGD 875
Cdd:cd07116   295 IYDRFMERALERVKAIKQGNPLDTETMIGAQASLEQLEKILSYIDIGKEEGAEVLTGgernelgGLLGGGYYVPTTFKGG 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  876 IRpeHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFG 955
Cdd:cd07116   375 NK--MRIFQEEIFGPVLAVTTFKDEEEALEIANDTLYGLGAGVWTRDGNTAYRMGRGIQAGRVWT--NCYHLYPAHAAFG 450

                  ....*...
gi 221564986  956 GFRLSGAG 963
Cdd:cd07116   451 GYKQSGIG 458
PLN02466 PLN02466
aldehyde dehydrogenase family 2 member
510-967 3.51e-59

aldehyde dehydrogenase family 2 member


Pssm-ID: 215259 [Multi-domain]  Cd Length: 538  Bit Score: 212.36  E-value: 3.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQELE--TEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFET--WRDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:PLN02466   60 LLINGQFVDaaSGKTFPTLDPRT-GEVIAHVAEGDAEDVNRAVAAARKAFDEgpWPKMTAYERSRILLRFADLLEKHNDE 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  586 LSALQVLEIGKQWDQ-AYADVTEAIDFLEYYAremirlgsprsmG---KVAGETN--------QYFYEPKGVAAVIAPWN 653
Cdd:PLN02466  139 LAALETWDNGKPYEQsAKAELPMFARLFRYYA------------GwadKIHGLTVpadgphhvQTLHEPIGVAGQIIPWN 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  654 FPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEV 733
Cdd:PLN02466  207 FPLLMFAWKVGPALACGNTIVLKTAEQTPLSALYAAKLLHEAGLPPGVLNVVSGFGPTAGAALASHMDVDKLAFTGSTDT 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  734 GLRIIERAAKVQpgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTA 813
Cdd:PLN02466  287 GKIVLELAAKSN-----LKPVTLELGGKSPFIVCEDADVDKAVELAHFALFFNQGQCCCAGSRTFVHERVYDEFVEKAKA 361
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  814 LAEAVPVGpveDPanlIGAVAEENAQ------KRIMNYIEVGRQEGRLLYQG--HVPEVGFFVPLTIIGDIRPEHRLAQE 885
Cdd:PLN02466  362 RALKRVVG---DP---FKKGVEQGPQidseqfEKILRYIKSGVESGATLECGgdRFGSKGYYIQPTVFSNVQDDMLIAQD 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  886 EIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLnrNCTGALVGRQPFGGFRLSGAGTK 965
Cdd:PLN02466  436 EIFGPVQSILKFKDLDEVIRRANNTRYGLAAGVFTQNLDTANTLSRALRVGTVWV--NCFDVFDAAIPFGGYKMSGIGRE 513

                  ..
gi 221564986  966 AG 967
Cdd:PLN02466  514 KG 515
ALDH_SSADH2_GabD2 cd07101
Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Succinate-semialdehyde ...
533-983 5.67e-59

Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Succinate-semialdehyde dehydrogenase 2 (SSADH2) and similar proteins are in this CD. SSADH1 (GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. SSADH activity in Mycobacterium tuberculosis is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731), however ,the Vmax of GabD1 was shown to be much higher than that of GabD2, and GabD2 (SSADH2) is likely to serve physiologically as a dehydrogenase for a different aldehyde(s).


Pssm-ID: 143419 [Multi-domain]  Cd Length: 454  Bit Score: 209.47  E-value: 5.67e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  533 EIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFL 612
Cdd:cd07101     7 EPLGELPQSTPADVEAAFARARAAQRAWAARPFAERAAVFLRFHDLVLERRDELLDLIQLETGKARRHAFEEVLDVAIVA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  613 EYYAREMIRLGSPRsmgKVAG-----ETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQ 687
Cdd:cd07101    87 RYYARRAERLLKPR---RRRGaipvlTRTTVNRRPKGVVGVISPWNYPLTLAVSDAIPALLAGNAVVLKPDSQTALTALW 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  688 LVDIFREVGLPDGVFNFVPGRSGIMGDYLVDhpHVSLIAFTGSMEVGLRIIERAAKVQPGQEMvkkvicEMGGKNAIIID 767
Cdd:cd07101   164 AVELLIEAGLPRDLWQVVTGPGSEVGGAIVD--NADYVMFTGSTATGRVVAERAGRRLIGCSL------ELGGKNPMIVL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  768 DDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIE 847
Cdd:cd07101   236 EDADLDKAAAGAVRACFSNAGQLCVSIERIYVHESVYDEFVRRFVARTRALRLGAALDYGPDMGSLISQAQLDRVTAHVD 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  848 VGRQEG-RLLYQGH-VPEVG--FFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSP 923
Cdd:cd07101   316 DAVAKGaTVLAGGRaRPDLGpyFYEP-TVLTGVTEDMELFAEETFGPVVSIYRVADDDEAIELANDTDYGLNASVWTRDG 394
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221564986  924 EHIAIATKRFRVGNLYLNRNCTGALVGRQ-PFGGFRLSGAGTKAgGPDYLLHFMDPRVVTE 983
Cdd:cd07101   395 ARGRRIAARLRAGTVNVNEGYAAAWASIDaPMGGMKDSGLGRRH-GAEGLLKYTETQTVAV 454
PRK09847 PRK09847
gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional
510-963 2.82e-58

gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional


Pssm-ID: 182108 [Multi-domain]  Cd Length: 494  Bit Score: 208.60  E-value: 2.82e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQELETED--LLPSMNPSDPSEIVGwVCQAGTDEVAQAIGAARKSFET--WRDITPEIRAEFLLKACTVVRRRIYE 585
Cdd:PRK09847   22 LFINGEYTAAAEneTFETVDPVTQAPLAK-IARGKSVDIDRAVSAARGVFERgdWSLSSPAKRKAVLNKLADLMEAHAEE 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  586 LSALQVLEIGKQWDQAYAD-VTEAIDFLEYYAREMIRLgsprsMGKVA----GETNQYFYEPKGVAAVIAPWNFPLAISM 660
Cdd:PRK09847  101 LALLETLDTGKPIRHSLRDdIPGAARAIRWYAEAIDKV-----YGEVAttssHELAMIVREPVGVIAAIVPWNFPLLLTC 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  661 GMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIER 740
Cdd:PRK09847  176 WKLGPALAAGNSVILKPSEKSPLSAIRLAGLAKEAGLPDGVLNVVTGFGHEAGQALSRHNDIDAIAFTGSTRTGKQLLKD 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  741 AakvqpGQEMVKKVICEMGGKNAIIIDDD-ADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVP 819
Cdd:PRK09847  256 A-----GDSNMKRVWLEAGGKSANIVFADcPDLQQAASATAAGIFYNQGQVCIAGTRLLLEESIADEFLALLKQQAQNWQ 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  820 VGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLY----QGHVPEVGffvPlTIIGDIRPEHRLAQEEIFGPLLAVM 895
Cdd:PRK09847  331 PGHPLDPATTMGTLIDCAHADSVHSFIREGESKGQLLLdgrnAGLAAAIG---P-TIFVDVDPNASLSREEIFGPVLVVT 406
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221564986  896 RARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVgrQPFGGFRLSGAG 963
Cdd:PRK09847  407 RFTSEEQALQLANDSQYGLGAAVWTRDLSRAHRMSRRLKAGSVFVNNYNDGDMT--VPFGGYKQSGNG 472
ALDH_F1L_FTFDH cd07140
10-formyltetrahydrofolate dehydrogenase, ALDH family 1L; 10-formyltetrahydrofolate ...
508-982 5.20e-58

10-formyltetrahydrofolate dehydrogenase, ALDH family 1L; 10-formyltetrahydrofolate dehydrogenase (FTHFDH, EC=1.5.1.6), also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1) in humans, is a multi-domain homotetramer with an N-terminal formyl transferase domain and a C-terminal ALDH domain. FTHFDH catalyzes an NADP+-dependent dehydrogenase reaction resulting in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. The ALDH domain is also capable of the oxidation of short chain aldehydes to their corresponding acids.


Pssm-ID: 143458 [Multi-domain]  Cd Length: 486  Bit Score: 207.73  E-value: 5.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  508 YPLFIGGQELETED--LLPSMNPSDPSEIVGwVCQAGTDEVAQAIGAARKSFET--WRDITPEIRAEFLLKACTVVRRRI 583
Cdd:cd07140     6 HQLFINGEFVDAEGgkTYNTINPTDGSVICK-VSLATVEDVDRAVAAAKEAFENgeWGKMNARDRGRLMYRLADLMEEHQ 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  584 YELSALQVLEIGKQWDQAY-ADVTEAIDFLEYYAREMIRL-GSPRSMGKVAGETNQYFY--EPKGVAAVIAPWNFPLAIS 659
Cdd:cd07140    85 EELATIESLDSGAVYTLALkTHVGMSIQTFRYFAGWCDKIqGKTIPINQARPNRNLTLTkrEPIGVCGIVIPWNYPLMML 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  660 MGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIE 739
Cdd:cd07140   165 AWKMAACLAAGNTVVLKPAQVTPLTALKFAELTVKAGFPKGVINILPGSGSLVGQRLSDHPDVRKLGFTGSTPIGKHIMK 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  740 RAAKVQpgqemVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVP 819
Cdd:cd07140   245 SCAVSN-----LKKVSLELGGKSPLIIFADCDMDKAVRMGMSSVFFNKGENCIAAGRLFVEESIHDEFVRRVVEEVKKMK 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  820 VGpveDPANLIGAVAEENAQK---RIMNYIEVGRQEG-RLLYQG-HVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAV 894
Cdd:cd07140   320 IG---DPLDRSTDHGPQNHKAhldKLVEYCERGVKEGaTLVYGGkQVDRPGFFFEPTVFTDVEDHMFIAKEESFGPIMII 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  895 MRAR--DFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNR-NCTGAlvgRQPFGGFRLSGAGtKAGGPDY 971
Cdd:cd07140   397 SKFDdgDVDGVLQRANDTEYGLASGVFTKDINKALYVSDKLEAGTVFVNTyNKTDV---AAPFGGFKQSGFG-KDLGEEA 472
                         490
                  ....*....|.
gi 221564986  972 LLHFMDPRVVT 982
Cdd:cd07140   473 LNEYLKTKTVT 483
astD PRK09457
succinylglutamic semialdehyde dehydrogenase; Reviewed
510-961 1.16e-57

succinylglutamic semialdehyde dehydrogenase; Reviewed


Pssm-ID: 181873  Cd Length: 487  Bit Score: 206.73  E-value: 1.16e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  510 LFIGGQELE-TEDLLPSMNPSDpSEIVgWVCQAGT-DEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELS 587
Cdd:PRK09457    3 LWINGDWIAgQGEAFESRNPVS-GEVL-WQGNDATaAQVDAAVRAARAAFPAWARLSFEERQAIVERFAALLEENKEELA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  588 ALQVLEIGK-QWDQAyadvTE--------AIDFLEYYARemirlgSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAI 658
Cdd:PRK09457   81 EVIARETGKpLWEAA----TEvtaminkiAISIQAYHER------TGEKRSEMADGAAVLRHRPHGVVAVFGPYNFPGHL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  659 SMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGiMGDYLVDHPHVSLIAFTGSMEVGLRII 738
Cdd:PRK09457  151 PNGHIVPALLAGNTVVFKPSELTPWVAELTVKLWQQAGLPAGVLNLVQGGRE-TGKALAAHPDIDGLLFTGSANTGYLLH 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  739 ERAAKvQPGqemvKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIY-DKFVQRLTALAEA 817
Cdd:PRK09457  230 RQFAG-QPE----KILALEMGGNNPLVIDEVADIDAAVHLIIQSAFISAGQRCTCARRLLVPQGAQgDAFLARLVAVAKR 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  818 VPVG-PVEDPANLIGAVAEENAQKRIM----NYIEVGrqeGRLLYQGHVPEVGF-FVPLTIIgDIRPEHRLAQEEIFGPL 891
Cdd:PRK09457  305 LTVGrWDAEPQPFMGAVISEQAAQGLVaaqaQLLALG---GKSLLEMTQLQAGTgLLTPGII-DVTGVAELPDEEYFGPL 380
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  892 LAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGAlVGRQPFGGFRLSG 961
Cdd:PRK09457  381 LQVVRYDDFDEAIRLANNTRFGLSAGLLSDDREDYDQFLLEIRAGIVNWNKPLTGA-SSAAPFGGVGASG 449
gabD PRK11241
NADP-dependent succinate-semialdehyde dehydrogenase I;
511-972 5.43e-57

NADP-dependent succinate-semialdehyde dehydrogenase I;


Pssm-ID: 183050 [Multi-domain]  Cd Length: 482  Bit Score: 204.76  E-value: 5.43e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  511 FIGGQELETE--DLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSA 588
Cdd:PRK11241   14 LINGEWLDANngEVIDVTNPAN-GDKLGSVPKMGADETRAAIDAANRALPAWRALTAKERANILRRWFNLMMEHQDDLAR 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  589 LQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIV 668
Cdd:PRK11241   93 LMTLEQGKPLAEAKGEISYAASFIEWFAEEGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALA 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  669 TGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKvqpgq 748
Cdd:PRK11241  173 AGCTMVLKPASQTPFSALALAELAIRAGIPAGVFNVVTGSAGAVGGELTSNPLVRKLSFTGSTEIGRQLMEQCAK----- 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  749 eMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPAN 828
Cdd:PRK11241  248 -DIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGVYDRFAEKLQQAVSKLHIGDGLEKGV 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  829 LIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGHVPEVG--FFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALV 905
Cdd:PRK11241  327 TIGPLIDEKAVAKVEEHIADALEKGaRVVCGGKAHELGgnFFQP-TILVDVPANAKVAKEETFGPLAPLFRFKDEADVIA 405
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221564986  906 WANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNrncTGALVGR-QPFGGFRLSG---AGTKAGGPDYL 972
Cdd:PRK11241  406 QANDTEFGLAAYFYARDLSRVFRVGEALEYGIVGIN---TGIISNEvAPFGGIKASGlgrEGSKYGIEDYL 473
ALDH_F15-22 cd07098
Aldehyde dehydrogenase family 15A1 and 22A1-like; Aldehyde dehydrogenase family members ...
542-984 6.76e-54

Aldehyde dehydrogenase family 15A1 and 22A1-like; Aldehyde dehydrogenase family members ALDH15A1 (Saccharomyces cerevisiae YHR039C) and ALDH22A1 (Arabidopsis thaliana, EC=1.2.1.3), and similar sequences, are in this CD. Significant improvement of stress tolerance in tobacco plants was observed by overexpressing the ALDH22A1 gene from maize (Zea mays) and was accompanied by a reduction of malondialdehyde derived from cellular lipid peroxidation.


Pssm-ID: 143416 [Multi-domain]  Cd Length: 465  Bit Score: 195.21  E-value: 6.76e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  542 GTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGK-QWDQAYADVTEAIDFLEYYAREMI 620
Cdd:cd07098    16 TPEDVDEAIAAARAAQREWAKTSFAERRKVLRSLLKYILENQEEICRVACRDTGKtMVDASLGEILVTCEKIRWTLKHGE 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  621 RLGSP--RSMGKVAG-ETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREV-- 695
Cdd:cd07098    96 KALRPesRPGGLLMFyKRARVEYEPLGVVGAIVSWNYPFHNLLGPIIAALFAGNAIVVKVSEQVAWSSGFFLSIIRECla 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  696 --GLPDGVFNFVPGRSGImGDYLVDHPHVSLIAFTGSMEVGLRIIERAAkvqpgqEMVKKVICEMGGKNAIIIDDDADLD 773
Cdd:cd07098   176 acGHDPDLVQLVTCLPET-AEALTSHPVIDHITFIGSPPVGKKVMAAAA------ESLTPVVLELGGKDPAIVLDDADLD 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  774 EAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG 853
Cdd:cd07098   249 QIASIIMRGTFQSSGQNCIGIERVIVHEKIYDKLLEILTDRVQALRQGPPLDGDVDVGAMISPARFDRLEELVADAVEKG 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  854 -RLLYQGH------VPEVGFFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHI 926
Cdd:cd07098   329 aRLLAGGKryphpeYPQGHYFPP-TLLVDVTPDMKIAQEEVFGPVMVVMKASDDEEAVEIANSTEYGLGASVFGKDIKRA 407
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 221564986  927 AIATKRFRVGNLYLNRNCTGALVGRQPFGGFRLSGAGtKAGGPDYLLHFMDPRVVTEN 984
Cdd:cd07098   408 RRIASQLETGMVAINDFGVNYYVQQLPFGGVKGSGFG-RFAGEEGLRGLCNPKSVTED 464
ALDH_F7_AASADH cd07130
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; ...
521-926 1.58e-53

NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as ALDH7A1, Antiquitin-1, ALDH7B, or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), is a NAD+-dependent ALDH. Human ALDH7A1 is involved in the pipecolic acid pathway of lysine catabolism, catalyzing the oxidation of alpha-aminoadipic semialdehyde to alpha-aminoadipate. Arabidopsis thaliana ALDH7B4 appears to be an osmotic-stress-inducible ALDH gene encoding a turgor-responsive or stress-inducible ALDH. The Streptomyces clavuligerus P6CDH appears to be involved in cephamycin biosynthesis, catalyzing the second stage of the two-step conversion of lysine to alpha-aminoadipic acid. The ALDH7A1 enzyme and others in this group have been observed as tetramers, yet the bacterial P6CDH enzyme has been reported as a monomer.


Pssm-ID: 143448  Cd Length: 474  Bit Score: 194.35  E-value: 1.58e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  521 DLLPSMNPSDPSEIVGwVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQ 600
Cdd:cd07130    12 GVVTSISPANGEPIAR-VRQATPEDYESTIKAAQEAFKEWRDVPAPKRGEIVRQIGDALRKKKEALGKLVSLEMGKILPE 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  601 AYADVTEAIDFLEYyaremiRLGSPRSM-GKV-AGE-TNQYFYE---PKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVV 674
Cdd:cd07130    91 GLGEVQEMIDICDF------AVGLSRQLyGLTiPSErPGHRMMEqwnPLGVVGVITAFNFPVAVWGWNAAIALVCGNVVV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  675 FKPS---GLTSIIGWQLV-DIFREVGLPDGVFNFVPGrSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAakvqpgQEM 750
Cdd:cd07130   165 WKPSpttPLTAIAVTKIVaRVLEKNGLPGAIASLVCG-GADVGEALVKDPRVPLVSFTGSTAVGRQVGQAV------AAR 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  751 VKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLI 830
Cdd:cd07130   238 FGRSLLELGGNNAIIVMEDADLDLAVRAVLFAAVGTAGQRCTTTRRLIVHESIYDEVLERLKKAYKQVRIGDPLDDGTLV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  831 GAVAEENAQKRIMNYIEVGR-QEGRLLYQGHVPEV-GFFVPLTIIgDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWAN 908
Cdd:cd07130   318 GPLHTKAAVDNYLAAIEEAKsQGGTVLFGGKVIDGpGNYVEPTIV-EGLSDAPIVKEETFAPILYVLKFDTLEEAIAWNN 396
                         410
                  ....*....|....*...
gi 221564986  909 STRYALTGGLFSRSPEHI 926
Cdd:cd07130   397 EVPQGLSSSIFTTDLRNA 414
ALDH_EDX86601 cd07102
Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); ...
541-942 6.44e-53

Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (locus EDX86601) and other similar sequences, are present in this CD.


Pssm-ID: 143420 [Multi-domain]  Cd Length: 452  Bit Score: 192.08  E-value: 6.44e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  541 AGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAyadvTEAIDFLEYYAREMI 620
Cdd:cd07102    15 ASLEAVRAALERARAAQKGWRAVPLEERKAIVTRAVELLAANTDEIAEELTWQMGRPIAQA----GGEIRGMLERARYMI 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  621 RLgSPRSMGKVAGETNQYF-----YEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREV 695
Cdd:cd07102    91 SI-AEEALADIRVPEKDGFeryirREPLGVVLIIAPWNYPYLTAVNAVIPALLAGNAVILKHSPQTPLCGERFAAAFAEA 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  696 GLPDGVFNFVPGRSGIMGDyLVDHPHVSLIAFTGSMEVGLRiIERAAkvqpgQEMVKKVICEMGGKNAIIIDDDADLDEA 775
Cdd:cd07102   170 GLPEGVFQVLHLSHETSAA-LIADPRIDHVSFTGSVAGGRA-IQRAA-----AGRFIKVGLELGGKDPAYVRPDADLDAA 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  776 VPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-R 854
Cdd:cd07102   243 AESLVDGAFFNSGQSCCSIERIYVHESIYDAFVEAFVAVVKGYKLGDPLDPSTTLGPVVSARAADFVRAQIADAIAKGaR 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  855 LLYQGHV----PEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEH-IAIA 929
Cdd:cd07102   323 ALIDGALfpedKAGGAYLAPTVLTNVDHSMRVMREETFGPVVGIMKVKSDAEAIALMNDSEYGLTASVWTKDIARaEALG 402
                         410
                  ....*....|...
gi 221564986  930 TkRFRVGNLYLNR 942
Cdd:cd07102   403 E-QLETGTVFMNR 414
gabD2 PRK09407
succinic semialdehyde dehydrogenase; Reviewed
533-983 7.57e-52

succinic semialdehyde dehydrogenase; Reviewed


Pssm-ID: 236501 [Multi-domain]  Cd Length: 524  Bit Score: 190.86  E-value: 7.57e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  533 EIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFL 612
Cdd:PRK09407   43 EPLATVPVSTAADVEAAFARARAAQRAWAATPVRERAAVLLRFHDLVLENREELLDLVQLETGKARRHAFEEVLDVALTA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  613 EYYAREMIRLGSPR---SMGKVAGETNQYfYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLV 689
Cdd:PRK09407  123 RYYARRAPKLLAPRrraGALPVLTKTTEL-RQPKGVVGVISPWNYPLTLAVSDAIPALLAGNAVVLKPDSQTPLTALAAV 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  690 DIFREVGLPDGVFNFVPGRSGIMGDYLVDhpHVSLIAFTGSMEVGLRIIERAAKVQPGqemvkkviC--EMGGKNAIIID 767
Cdd:PRK09407  202 ELLYEAGLPRDLWQVVTGPGPVVGTALVD--NADYLMFTGSTATGRVLAEQAGRRLIG--------FslELGGKNPMIVL 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  768 DDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIE 847
Cdd:PRK09407  272 DDADLDKAAAGAVRACFSNAGQLCISIERIYVHESIYDEFVRAFVAAVRAMRLGAGYDYSADMGSLISEAQLETVSAHVD 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  848 VGRQEG-RLLYQGHV-PEVG--FFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSP 923
Cdd:PRK09407  352 DAVAKGaTVLAGGKArPDLGplFYEP-TVLTGVTPDMELAREETFGPVVSVYPVADVDEAVERANDTPYGLNASVWTGDT 430
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221564986  924 EH-IAIATkRFRVGNLYLNRNCTGALVGRQ-PFGGFRLSGAGTKAgGPDYLLHFMDPRVVTE 983
Cdd:PRK09407  431 ARgRAIAA-RIRAGTVNVNEGYAAAWGSVDaPMGGMKDSGLGRRH-GAEGLLKYTESQTIAT 490
PLN00412 PLN00412
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional
540-965 3.24e-47

NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional


Pssm-ID: 215110 [Multi-domain]  Cd Length: 496  Bit Score: 176.87  E-value: 3.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  540 QAGT-DEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYARE 618
Cdd:PLN00412   48 QACTqEEVNKAMESAKAAQKAWAKTPLWKRAELLHKAAAILKEHKAPIAECLVKEIAKPAKDAVTEVVRSGDLISYTAEE 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  619 MIRLgspRSMGKV-------AGETNQYFYE---PKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQL 688
Cdd:PLN00412  128 GVRI---LGEGKFlvsdsfpGNERNKYCLTskiPLGVVLAIPPFNYPVNLAVSKIAPALIAGNAVVLKPPTQGAVAALHM 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  689 VDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSmEVGLRIIERAAKVqPGQemvkkviCEMGGKNAIIIDD 768
Cdd:PLN00412  205 VHCFHLAGFPKGLISCVTGKGSEIGDFLTMHPGVNCISFTGG-DTGIAISKKAGMV-PLQ-------MELGGKDACIVLE 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  769 DADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANlIGAVAEENAQKRIMNYIEV 848
Cdd:PLN00412  276 DADLDLAAANIIKGGFSYSGQRCTAVKVVLVMESVADALVEKVNAKVAKLTVGPPEDDCD-ITPVVSESSANFIEGLVMD 354
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  849 GRQEGRLLYQGHVPEVGFFVPLtIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAI 928
Cdd:PLN00412  355 AKEKGATFCQEWKREGNLIWPL-LLDNVRPDMRIAWEEPFGPVLPVIRINSVEEGIHHCNASNFGLQGCVFTRDINKAIL 433
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 221564986  929 ATKRFRVGNLYLNrnctgALVGRQ----PFGGFRLSGAGTK 965
Cdd:PLN00412  434 ISDAMETGTVQIN-----SAPARGpdhfPFQGLKDSGIGSQ 469
gabD1 PRK09406
succinic semialdehyde dehydrogenase; Reviewed
541-963 1.26e-45

succinic semialdehyde dehydrogenase; Reviewed


Pssm-ID: 181826 [Multi-domain]  Cd Length: 457  Bit Score: 171.07  E-value: 1.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  541 AGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYYAR--E 618
Cdd:PRK09406   20 LTDDEVDAAIARAHARFRDYRTTTFAQRARWANAAADLLEAEADQVAALMTLEMGKTLASAKAEALKCAKGFRYYAEhaE 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  619 MIRLGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLP 698
Cdd:PRK09406  100 ALLADEPADAAAVGASRAYVRYQPLGVVLAVMPWNFPLWQVVRFAAPALMAGNVGLLKHASNVPQTALYLADLFRRAGFP 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  699 DGVFNFVPGRSGIMGDYLVDhPHVSLIAFTGSMEVGlriieRAAKVQPGQEmVKKVICEMGGKNAIIIDDDADLDEAVPH 778
Cdd:PRK09406  180 DGCFQTLLVGSGAVEAILRD-PRVAAATLTGSEPAG-----RAVAAIAGDE-IKKTVLELGGSDPFIVMPSADLDRAAET 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  779 VFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLY 857
Cdd:PRK09406  253 AVTARVQNNGQSCIAAKRFIVHADVYDAFAEKFVARMAALRVGDPTDPDTDVGPLATEQGRDEVEKQVDDAVAAGaTILC 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  858 QGHVPE-VGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVG 936
Cdd:PRK09406  333 GGKRPDgPGWFYPPTVITDITPDMRLYTEEVFGPVASLYRVADIDEAIEIANATTFGLGSNAWTRDEAEQERFIDDLEAG 412
                         410       420
                  ....*....|....*....|....*....
gi 221564986  937 NLYLNRNCTG--ALvgrqPFGGFRLSGAG 963
Cdd:PRK09406  413 QVFINGMTVSypEL----PFGGVKRSGYG 437
PLN02419 PLN02419
methylmalonate-semialdehyde dehydrogenase [acylating]
507-935 1.48e-45

methylmalonate-semialdehyde dehydrogenase [acylating]


Pssm-ID: 166060 [Multi-domain]  Cd Length: 604  Bit Score: 174.16  E-value: 1.48e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  507 KYPLFIGGQELETED--LLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIY 584
Cdd:PLN02419  113 RVPNLIGGSFVESQSssFIDVINPAT-QEVVSKVPLTTNEEFKAAVSAAKQAFPLWRNTPITTRQRVMLKFQELIRKNMD 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  585 ELSALQVLEIGKQWDQAYADVTEAIDFLEYyAREMIRLGSPRSMGKVAGETNQY-FYEPKGVAAVIAPWNFPLAISMGMV 663
Cdd:PLN02419  192 KLAMNITTEQGKTLKDSHGDIFRGLEVVEH-ACGMATLQMGEYLPNVSNGVDTYsIREPLGVCAGICPFNFPAMIPLWMF 270
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  664 SAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMgDYLVDHPHVSLIAFTGSMEVGLRIIERAAK 743
Cdd:PLN02419  271 PVAVTCGNTFILKPSEKDPGASVILAELAMEAGLPDGVLNIVHGTNDTV-NAICDDEDIRAVSFVGSNTAGMHIYARAAA 349
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  744 VQpgqemvKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVL---DGIYDKFVQRltalAEAVPV 820
Cdd:PLN02419  350 KG------KRIQSNMGAKNHGLVLPDANIDATLNALLAAGFGAAGQRCMALSTVVFVgdaKSWEDKLVER----AKALKV 419
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  821 GPVEDPANLIGAVAEENAQKRIMNYIEVGRQEG-RLLYQGH---VP--EVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAV 894
Cdd:PLN02419  420 TCGSEPDADLGPVISKQAKERICRLIQSGVDDGaKLLLDGRdivVPgyEKGNFIGPTILSGVTPDMECYKEEIFGPVLVC 499
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 221564986  895 MRARDFNEALVWANSTRYALTGGLFSRSpehiAIATKRFRV 935
Cdd:PLN02419  500 MQANSFDEAISIINKNKYGNGAAIFTSS----GAAARKFQM 536
PRK13968 PRK13968
putative succinate semialdehyde dehydrogenase; Provisional
525-963 5.56e-42

putative succinate semialdehyde dehydrogenase; Provisional


Pssm-ID: 184426 [Multi-domain]  Cd Length: 462  Bit Score: 160.41  E-value: 5.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  525 SMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYAD 604
Cdd:PRK13968   11 SVNPAT-GEQLSVLPWAGADDIENALQLAAAGFRDWRETNIDYRAQKLRDIGKALRARSEEMAQMITREMGKPINQARAE 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  605 VTEAIDFLEYYAREMIRLGSPRSmgkVAGETNQYF--YEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPS---- 678
Cdd:PRK13968   90 VAKSANLCDWYAEHGPAMLKAEP---TLVENQQAVieYRPLGTILAIMPWNFPLWQVMRGAVPILLAGNGYLLKHApnvm 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  679 GLTSIIGwqlvDIFREVGLPDGVFNFV----PGRSGIMGDylvdhPHVSLIAFTGSMEVGLRIIERAAKVqpgqemVKKV 754
Cdd:PRK13968  167 GCAQLIA----QVFKDAGIPQGVYGWLnadnDGVSQMIND-----SRIAAVTVTGSVRAGAAIGAQAGAA------LKKC 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  755 ICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVA 834
Cdd:PRK13968  232 VLELGGSDPFIVLNDADLELAVKAAVAGRYQNTGQVCAAAKRFIIEEGIASAFTERFVAAAAALKMGDPRDEENALGPMA 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  835 EENAQKRIMNYIEVGRQEG-RLLYQGH-VPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRY 912
Cdd:PRK13968  312 RFDLRDELHHQVEATLAEGaRLLLGGEkIAGAGNYYAPTVLANVTPEMTAFREELFGPVAAITVAKDAEHALELANDSEF 391
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 221564986  913 ALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCtgALVGRQPFGGFRLSGAG 963
Cdd:PRK13968  392 GLSATIFTTDETQARQMAARLECGGVFINGYC--ASDARVAFGGVKKSGFG 440
PLN02315 PLN02315
aldehyde dehydrogenase family 7 member
484-967 1.08e-40

aldehyde dehydrogenase family 7 member


Pssm-ID: 177949  Cd Length: 508  Bit Score: 157.69  E-value: 1.08e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  484 FTREEQRqaFREHIGQVRSRFGrkypLFIGGQELETEDLLPSMNPSDpSEIVGWVCQAGTDEVAQAIGAARKSFETWRDI 563
Cdd:PLN02315    3 FARKEYE--FLSEIGLSSRNLG----CYVGGEWRANGPLVSSVNPAN-NQPIAEVVEASLEDYEEGLRACEEAAKIWMQV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  564 TPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYADVTEAIDFLEYyaremiRLGSPRSM-GKV--AGETNQYFY 640
Cdd:PLN02315   76 PAPKRGEIVRQIGDALRAKLDYLGRLVSLEMGKILAEGIGEVQEIIDMCDF------AVGLSRQLnGSIipSERPNHMMM 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  641 E---PKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREV----GLPDGVFNFVPGRSGImG 713
Cdd:PLN02315  150 EvwnPLGIVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKLVAEVleknNLPGAIFTSFCGGAEI-G 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  714 DYLVDHPHVSLIAFTGSMEVGLrIIERAAKVQPGqemvkKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSA 793
Cdd:PLN02315  229 EAIAKDTRIPLVSFTGSSKVGL-MVQQTVNARFG-----KCLLELSGNNAIIVMDDADIQLAVRSVLFAAVGTAGQRCTT 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  794 CSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGR-QEGRLLYQGHVPEV-GFFVPLT 871
Cdd:PLN02315  303 CRRLLLHESIYDDVLEQLLTVYKQVKIGDPLEKGTLLGPLHTPESKKNFEKGIEIIKsQGGKILTGGSAIESeGNFVQPT 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  872 IIgDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIA--IATKRFRVGNLYLNRNCTGALV 949
Cdd:PLN02315  383 IV-EISPDADVVKEELFGPVLYVMKFKTLEEAIEINNSVPQGLSSSIFTRNPETIFkwIGPLGSDCGIVNVNIPTNGAEI 461
                         490
                  ....*....|....*...
gi 221564986  950 GrQPFGGFRLSGAGTKAG 967
Cdd:PLN02315  462 G-GAFGGEKATGGGREAG 478
ALDH_RL0313 cd07148
Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ...
527-976 8.05e-39

Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Uncharacterized aldehyde dehydrogenase (locus RL0313) with sequence similarity to the moss Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123) believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and similar sequences are included in this CD.


Pssm-ID: 143466 [Multi-domain]  Cd Length: 455  Bit Score: 151.03  E-value: 8.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  527 NPSDPSEIvGWVCQAGTDEVAQAIGAARKSFET---WrdITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYA 603
Cdd:cd07148     5 NPFDLKPI-GEVPTVDWAAIDKALDTAHALFLDrnnW--LPAHERIAILERLADLMEERADELALLIAREGGKPLVDAKV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  604 DVTEAIDFLEYYAREMIRL-GSPRSMGKVAGETNQYFY---EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSG 679
Cdd:cd07148    82 EVTRAIDGVELAADELGQLgGREIPMGLTPASAGRIAFttrEPIGVVVAISAFNHPLNLIVHQVAPAIAAGCPVIVKPAL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  680 LTSIIGWQLVDIFREVGLPDGVFNFVPGRSGImGDYLVDHPHVSLIAFTGSMEVGLRIierAAKVQPGqemvKKVICEMG 759
Cdd:cd07148   162 ATPLSCLAFVDLLHEAGLPEGWCQAVPCENAV-AEKLVTDPRVAFFSFIGSARVGWML---RSKLAPG----TRCALEHG 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  760 GKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQ 839
Cdd:cd07148   234 GAAPVIVDRSADLDAMIPPLVKGGFYHAGQVCVSVQRVFVPAEIADDFAQRLAAAAEKLVVGDPTDPDTEVGPLIRPREV 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  840 KRIMNYIEVGRQEG-RLLYQGHVPEVGFFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGL 918
Cdd:cd07148   314 DRVEEWVNEAVAAGaRLLCGGKRLSDTTYAP-TVLLDPPRDAKVSTQEIFGPVVCVYSYDDLDEAIAQANSLPVAFQAAV 392
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221564986  919 FSRSpehIAIATKRFRvgnlylNRNCTGALVGRQ--------PFGGFRLSGAGTkaGGPDYLLHFM 976
Cdd:cd07148   393 FTKD---LDVALKAVR------RLDATAVMVNDHtafrvdwmPFAGRRQSGYGT--GGIPYTMHDM 447
ALDH_KGSADH-like cd07084
ALDH subfamily: NAD(P)+-dependent alpha-ketoglutaric semialdehyde dehydrogenases and plant ...
546-981 1.52e-36

ALDH subfamily: NAD(P)+-dependent alpha-ketoglutaric semialdehyde dehydrogenases and plant delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH family 12-like; ALDH subfamily which includes the NAD(P)+-dependent, alpha-ketoglutaric semialdehyde dehydrogenases (KGSADH, EC 1.2.1.26); plant delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, EC=1.5.1.12 ), ALDH family 12; the N-terminal domain of the MaoC (monoamine oxidase C) dehydratase regulatory protein; and orthologs of MaoC, PaaZ and PaaN, which are putative ring-opening enzymes of the aerobic phenylacetic acid catabolic pathway.


Pssm-ID: 143403 [Multi-domain]  Cd Length: 442  Bit Score: 143.92  E-value: 1.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  546 VAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAYaDVTEAIDFLEYYAR----EMIR 621
Cdd:cd07084     1 PERALLAADISTKAARRLALPKRADFLARIIQRLAAKSYDIAAGAVLVTGKGWMFAE-NICGDQVQLRARAFviysYRIP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  622 LGSPRSMGKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVG-LPDG 700
Cdd:cd07084    80 HEPGNHLGQGLKQQSHGYRWPYGPVLVIGAFNFPLWIPLLQLAGALAMGNPVIVKPHTAVSIVMQIMVRLLHYAGlLPPE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  701 VFNFVPGrSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVQpgqemvkkVICEMGGKNAIIIDDDADLDEAVP-HV 779
Cdd:cd07084   160 DVTLING-DGKTMQALLLHPNPKMVLFTGSSRVAEKLALDAKQAR--------IYLELAGFNWKVLGPDAQAVDYVAwQC 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  780 FNSAFGFQGQKCSACSRVIVL-DGIYDKFVQRLTALAEAVP-----VGPVEDPANLIGAVAEENAQKRIMNY--IEVGRQ 851
Cdd:cd07084   231 VQDMTACSGQKCTAQSMLFVPeNWSKTPLVEKLKALLARRKledllLGPVQTFTTLAMIAHMENLLGSVLLFsgKELKNH 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  852 EGRLLYQGHVPEvGFFVPltiIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRY--ALTGGLFSRSPEHI-AI 928
Cdd:cd07084   311 SIPSIYGACVAS-ALFVP---IDEILKTYELVTEEIFGPFAIVVEYKKDQLALVLELLERMhgSLTAAIYSNDPIFLqEL 386
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 221564986  929 ATKRFRVGNLY-LNRNCTGALVGRQPFGGFRLSGAGTKAGGPDYLLHFMDPRVV 981
Cdd:cd07084   387 IGNLWVAGRTYaILRGRTGVAPNQNHGGGPAADPRGAGIGGPEAIKLVWRCHAE 440
ALDH_F14-YMR110C cd07135
Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins; Aldehyde ...
641-963 5.72e-35

Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins; Aldehyde dehydrogenase family 14 (ALDH14), isolated mainly from the mitochondrial outer membrane of Saccharomyces cerevisiae (YMR110C) and most closely related to the plant and animal ALDHs and fatty ALDHs family 3 members, and similar fungal sequences, are present in this CD.


Pssm-ID: 143453 [Multi-domain]  Cd Length: 436  Bit Score: 139.28  E-value: 5.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  641 EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREvGLPDGVFNFVPGRSGIMGdYLVDHp 720
Cdd:cd07135   107 EPLGVVLIIGPWNYPVLLALSPLVGAIAAGCTVVLKPSELTPHTAALLAELVPK-YLDPDAFQVVQGGVPETT-ALLEQ- 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  721 HVSLIAFTGSMEVGlRII-ERAAK-VQPgqemvkkVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSRVI 798
Cdd:cd07135   184 KFDKIFYTGSGRVG-RIIaEAAAKhLTP-------VTLELGGKSPVIVTKNADLELAAKRILWGKFGNAGQICVAPDYVL 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  799 VLDGIYDKFVQRL-TALAEAVPVGPVEDPAnlIGAVAEENAQKRIMNYIEvgRQEGRLLYQGHVPEVGFFVPLTIIGDIR 877
Cdd:cd07135   256 VDPSVYDEFVEELkKVLDEFYPGGANASPD--YTRIVNPRHFNRLKSLLD--TTKGKVVIGGEMDEATRFIPPTIVSDVS 331
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  878 PEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQPFGGF 957
Cdd:cd07135   332 WDDSLMSEELFGPVLPIIKVDDLDEAIKVINSRDTPLALYIFTDDKSEIDHILTRTRSGGVVINDTLIHVGVDNAPFGGV 411

                  ....*.
gi 221564986  958 RLSGAG 963
Cdd:cd07135   412 GDSGYG 417
ALDH_AlkH-like cd07134
Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Aldehyde dehydrogenase AlkH (locus name ...
547-968 3.50e-34

Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Aldehyde dehydrogenase AlkH (locus name P12693, EC=1.2.1.3) of the alkBFGHJKL operon that allows Pseudomonas putida to metabolize alkanes and the aldehyde dehydrogenase AldX of Bacillus subtilis (locus P46329, EC=1.2.1.3), and similar sequences, are present in this CD.


Pssm-ID: 143452 [Multi-domain]  Cd Length: 433  Bit Score: 136.59  E-value: 3.50e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  547 AQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQwdQAYADVTE----------AIDFLEYYA 616
Cdd:cd07134     1 RRVFAAQQAHALALRASTAAERIAKLKRLKKAILARREEIIAALAADFRKP--AAEVDLTEilpvlseinhAIKHLKKWM 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  617 REMiRLGSPRSMgkvAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVG 696
Cdd:cd07134    79 KPK-RVRTPLLL---FGTKSKIRYEPKGVCLIISPWNYPFNLAFGPLVSAIAAGNTAILKPSELTPHTSAVIAKIIREAF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  697 LPDGVFNFVpgrsgimGDYLV---------DHphvslIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNAIIID 767
Cdd:cd07134   155 DEDEVAVFE-------GDAEVaqallelpfDH-----IFFTGSPAVGKIVMAAAAK------HLASVTLELGGKSPTIVD 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  768 DDADLDEAVPHVFNSAFGFQGQKCSACSRVIVLDGIYDKFVQRLTALAEAV--PVGPVEDPANLIGAVAEENAQkRIMNY 845
Cdd:cd07134   217 ETADLKKAAKKIAWGKFLNAGQTCIAPDYVFVHESVKDAFVEHLKAEIEKFygKDAARKASPDLARIVNDRHFD-RLKGL 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  846 IEVGRQEGRLLYQG--HVPEVGFFVPlTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSP 923
Cdd:cd07134   296 LDDAVAKGAKVEFGgqFDAAQRYIAP-TVLTNVTPDMKIMQEEIFGPVLPIITYEDLDEVIEYINAKPKPLALYVFSKDK 374
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 221564986  924 EHIAIATKRFRVGNLYLNRNCTGALVGRQPFGGFRLSGAGtKAGG 968
Cdd:cd07134   375 ANVNKVLARTSSGGVVVNDVVLHFLNPNLPFGGVNNSGIG-SYHG 418
PTZ00381 PTZ00381
aldehyde dehydrogenase family protein; Provisional
640-963 1.03e-32

aldehyde dehydrogenase family protein; Provisional


Pssm-ID: 240392  Cd Length: 493  Bit Score: 133.62  E-value: 1.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  640 YEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGL---TSIIGWQLVDIFrevgLPDGVFNFVPGRSGIMGDyL 716
Cdd:PTZ00381  107 PEPLGVVLVIGAWNYPLNLTLIPLAGAIAAGNTVVLKPSELsphTSKLMAKLLTKY----LDPSYVRVIEGGVEVTTE-L 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  717 VDHPhVSLIAFTGSMEVGlRIIERAAkvqpGQEMVkKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGFQGQKCSACSR 796
Cdd:PTZ00381  182 LKEP-FDHIFFTGSPRVG-KLVMQAA----AENLT-PCTLELGGKSPVIVDKSCNLKVAARRIAWGKFLNAGQTCVAPDY 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  797 VIVLDGIYDKFVQrltALAEAVPVGPVEDPANL--IGAVAEENAQKRIMNYIEvgRQEGRLLYQGHVPEVGFFVPLTIIG 874
Cdd:PTZ00381  255 VLVHRSIKDKFIE---ALKEAIKEFFGEDPKKSedYSRIVNEFHTKRLAELIK--DHGGKVVYGGEVDIENKYVAPTIIV 329
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  875 DIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQPF 954
Cdd:PTZ00381  330 NPDLDSPLMQEEIFGPILPILTYENIDEVLEFINSRPKPLALYYFGEDKRHKELVLENTSSGAVVINDCVFHLLNPNLPF 409

                  ....*....
gi 221564986  955 GGFRLSGAG 963
Cdd:PTZ00381  410 GGVGNSGMG 418
PutA_N pfam18083
Proline utilization A N-terminal domain; This domain is found in Proline utilization A (PutA) ...
8-117 9.91e-30

Proline utilization A N-terminal domain; This domain is found in Proline utilization A (PutA) proteins present in Geobacter sulfurreducens. PutA are bifunctional peripheral membrane flavoenzymes that catalyze the oxidation of l-proline to l-glutamate and couple the oxidation of imported proline imported to the reduction of membrane-associated quinones. This domain is located at the N-terminus and is referred to as the alpha domain. The hydrocarbon tail of Zwittergent 3-12 binds to an exposed hydrophobic patch of the alpha domain which contains aromatic and nonpolar residues. The domain may be involved in membrane association.


Pssm-ID: 436258  Cd Length: 113  Bit Score: 113.99  E-value: 9.91e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986     8 RRIVSCGREMFAGIYGETPSLFDKGRWLGKLMAWSMSDEEFKTRLFRFVDVFPTLSTDRMVADHLEEYFDGAQPPVLALL 87
Cdd:pfam18083    2 ARTQRIGRELFAALSGERPSLFDRRWWDDKLMEWAMKDEQLKVQLFRFVDVLPALKTPAEVARHLREYLGDVQDELPQPL 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 221564986    88 RQAAGVFGpfGNFIQRKAVSTAIRK----MAQQF 117
Cdd:pfam18083   82 RWALRAAD--GGSLGGRALAKAARKgaeqMARRF 113
ALDH_F3-13-14_CALDH-like cd07087
ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other ...
640-963 1.59e-29

ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; ALDH subfamily which includes NAD(P)+-dependent, aldehyde dehydrogenase, family 3 member A1 and B1 (ALDH3A1, ALDH3B1, EC=1.2.1.5) and fatty aldehyde dehydrogenase, family 3 member A2 (ALDH3A2, EC=1.2.1.3), and also plant ALDH family members ALDH3F1, ALDH3H1, and ALDH3I1, fungal ALDH14 (YMR110C) and the protozoan family 13 member (ALDH13), as well as coniferyl aldehyde dehydrogenases (CALDH, EC=1.2.1.68), and other similar sequences, such as the Pseudomonas putida benzaldehyde dehydrogenase I that is involved in the metabolism of mandelate.


Pssm-ID: 143406 [Multi-domain]  Cd Length: 426  Bit Score: 122.63  E-value: 1.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  640 YEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGL---TSIIgwqLVDIFREVgLPDGVFNFVPGrsgimGDY- 715
Cdd:cd07087    98 PEPLGVVLIIGPWNYPLQLALAPLIGAIAAGNTVVLKPSELapaTSAL---LAKLIPKY-FDPEAVAVVEG-----GVEv 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  716 ---LVDHP--HvslIAFTGSMEVGLRIIERAAK-VQPgqemvkkVICEMGGKNaiiidddadldeavP-HVFNSA----- 783
Cdd:cd07087   169 ataLLAEPfdH---IFFTGSPAVGKIVMEAAAKhLTP-------VTLELGGKS--------------PcIVDKDAnleva 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  784 --------FGFQGQKCSACSRVIVLDGIYDKFVQRLT-ALAEAVPvgpvEDPANL--IGAVAEENAQKRIMNYIEvgrqE 852
Cdd:cd07087   225 arriawgkFLNAGQTCIAPDYVLVHESIKDELIEELKkAIKEFYG----EDPKESpdYGRIINERHFDRLASLLD----D 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  853 GRLLYQGHVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKR 932
Cdd:cd07087   297 GKVVIGGQVDKEERYIAPTILDDVSPDSPLMQEEIFGPILPILTYDDLDEAIEFINSRPKPLALYLFSEDKAVQERVLAE 376
                         330       340       350
                  ....*....|....*....|....*....|.
gi 221564986  933 FRVGNLYLNRNCTGALVGRQPFGGFRLSGAG 963
Cdd:cd07087   377 TSSGGVCVNDVLLHAAIPNLPFGGVGNSGMG 407
ALDH_CALDH_CalB cd07133
Coniferyl aldehyde dehydrogenase-like; Coniferyl aldehyde dehydrogenase (CALDH, EC=1.2.1.68) ...
632-963 1.44e-24

Coniferyl aldehyde dehydrogenase-like; Coniferyl aldehyde dehydrogenase (CALDH, EC=1.2.1.68) of Pseudomonas sp. strain HR199 (CalB) which catalyzes the NAD+-dependent oxidation of coniferyl aldehyde to ferulic acid, and similar sequences, are present in this CD.


Pssm-ID: 143451 [Multi-domain]  Cd Length: 434  Bit Score: 107.96  E-value: 1.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  632 AGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVGLPDGVfnfvpgrSGI 711
Cdd:cd07133    91 LPAKAEVEYQPLGVVGIIVPWNYPLYLALGPLIAALAAGNRVMIKPSEFTPRTSALLAELLAEYFDEDEV-------AVV 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  712 MGDYLV---------DHphvsLIaFTGSMEVGlRIIERAA-------------K----VQPGQEMVKKVICEMGGKnaii 765
Cdd:cd07133   164 TGGADVaaafsslpfDH----LL-FTGSTAVG-RHVMRAAaenltpvtlelggKspaiIAPDADLAKAAERIAFGK---- 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  766 idddadldeavphVFNSafgfqGQKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPAnlIGAVAEENAQKRIMNY 845
Cdd:cd07133   234 -------------LLNA-----GQTCVAPDYVLVPEDKLEEFVAAAKAAVAKMYPTLADNPD--YTSIINERHYARLQGL 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  846 IEVGRQEG-RLLYQGHVPEV---GFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSR 921
Cdd:cd07133   294 LEDARAKGaRVIELNPAGEDfaaTRKLPPTLVLNVTDDMRVMQEEIFGPILPILTYDSLDEAIDYINARPRPLALYYFGE 373
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 221564986  922 SPEHIAIATKRFRVGNLYLNRNCTGALVGRQPFGGFRLSGAG 963
Cdd:cd07133   374 DKAEQDRVLRRTHSGGVTINDTLLHVAQDDLPFGGVGASGMG 415
ALDH_YwdH-P39616 cd07136
Bacillus subtilis aldehyde dehydrogenase ywdH-like; Uncharacterized Bacillus subtilis ywdH ...
637-963 7.48e-24

Bacillus subtilis aldehyde dehydrogenase ywdH-like; Uncharacterized Bacillus subtilis ywdH aldehyde dehydrogenase (locus P39616) most closely related to the ALDHs and fatty ALDHs of families 3 and 14, and similar sequences, are included in this CD.


Pssm-ID: 143454 [Multi-domain]  Cd Length: 449  Bit Score: 106.05  E-value: 7.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  637 QYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGL---TSIIgwqLVDIFREVgLPDGVFNFVPG---RSG 710
Cdd:cd07136    95 YIYYEPYGVVLIIAPWNYPFQLALAPLIGAIAAGNTAVLKPSELtpnTSKV---IAKIIEET-FDEEYVAVVEGgveENQ 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  711 IMGDYLVDHphvslIAFTGSMEVGLRIIERAAK-VQPgqemvkkVICEMGGKNaiiidddadldeavPHVFNS------- 782
Cdd:cd07136   171 ELLDQKFDY-----IFFTGSVRVGKIVMEAAAKhLTP-------VTLELGGKS--------------PCIVDEdanlkla 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  783 ----AFG-F--QGQKCSACSRVIVLDGIYDKFVQRL-TALAEAVPVGPVEDP--ANLIgavaeeNAQ--KRIMNYIEvgr 850
Cdd:cd07136   225 akriVWGkFlnAGQTCVAPDYVLVHESVKEKFIKELkEEIKKFYGEDPLESPdyGRII------NEKhfDRLAGLLD--- 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  851 qEGRLLYQGHVPEVGFFVPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIAT 930
Cdd:cd07136   296 -NGKIVFGGNTDRETLYIEPTILDNVTWDDPVMQEEIFGPILPVLTYDTLDEAIEIIKSRPKPLALYLFSEDKKVEKKVL 374
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 221564986  931 KRFRVG------------NLYLnrnctgalvgrqPFGGFRLSGAG 963
Cdd:cd07136   375 ENLSFGggcindtimhlaNPYL------------PFGGVGNSGMG 407
ALDH_F3AB cd07132
Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins; NAD(P)+-dependent, ...
641-963 5.50e-20

Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins; NAD(P)+-dependent, aldehyde dehydrogenase, family 3 members A1 and B1 (ALDH3A1, ALDH3B1, EC=1.2.1.5) and fatty aldehyde dehydrogenase, family 3 member A2 (ALDH3A2, EC=1.2.1.3), and similar sequences are included in this CD. Human ALDH3A1 is a homodimer with a critical role in cellular defense against oxidative stress; it catalyzes the oxidation of various cellular membrane lipid-derived aldehydes. Corneal crystalline ALDH3A1 protects the cornea and underlying lens against UV-induced oxidative stress. Human ALDH3A2, a microsomal homodimer, catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Human ALDH3B1 is highly expressed in the kidney and liver and catalyzes the oxidation of various medium- and long-chain saturated and unsaturated aliphatic aldehydes.


Pssm-ID: 143450 [Multi-domain]  Cd Length: 443  Bit Score: 94.21  E-value: 5.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  641 EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIfrevgLPD-------GVFNFVPGRSGIMG 713
Cdd:cd07132    99 EPLGVVLIIGAWNYPLQLTLVPLVGAIAAGNCVVIKPSEVSPATAKLLAEL-----IPKyldkecyPVVLGGVEETTELL 173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  714 DYLVDHphvslIAFTGSMEVGlRIIERAAkvqpgQEMVKKVICEMGGKNAIIIDDDADLDEAVPHV-----FNSafgfqG 788
Cdd:cd07132   174 KQRFDY-----IFYTGSTSVG-KIVMQAA-----AKHLTPVTLELGGKSPCYVDKSCDIDVAARRIawgkfINA-----G 237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  789 QKCSACSRVIVLDGIYDKFVQRL-TALAEAVPVGPVEDPaNLIGAVAEENAQkRIMNYIEvgrqEGRLLYQGHVPEVGFF 867
Cdd:cd07132   238 QTCIAPDYVLCTPEVQEKFVEALkKTLKEFYGEDPKESP-DYGRIINDRHFQ-RLKKLLS----GGKVAIGGQTDEKERY 311
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  868 VPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGA 947
Cdd:cd07132   312 IAPTVLTDVKPSDPVMQEEIFGPILPIVTVNNLDEAIEFINSREKPLALYVFSNNKKVINKILSNTSSGGVCVNDTIMHY 391
                         330
                  ....*....|....*.
gi 221564986  948 LVGRQPFGGFRLSGAG 963
Cdd:cd07132   392 TLDSLPFGGVGNSGMG 407
PLN02681 PLN02681
proline dehydrogenase
103-424 9.17e-19

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 90.53  E-value: 9.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  103 RKAVSTAIRKMA-QQFIVGENTTEAISNIERLRHQGFAAVVDVLGEATLSEKEADAYVDQYLDLIGSIERAMGRWK---- 177
Cdd:PLN02681   73 RAIVLALVKATFySHFCAGEDAEEAARTVRRLWELGLGGILDYAAEDAGDNAACDRNLEKFLAAIRAAATLPPSSSsaav 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  178 ------PLG-AGRTSGSMDWGHA-PRINVSVKATA--LSCLASPM------------DYEGSVAAILRRLRLICRRVREV 235
Cdd:PLN02681  153 kitalcPPSlLERVSDLLRWQDRdPNGKLPWKQWSfpLFADSSPLyhatsepepltaEEERLLELAHERLQKLCERAAQL 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  236 NGFLCLDMETYRYKEIILEVYRRLKLE---NPDYHHLGLVLQSYLRDTDHDLDNLVTWARENCLGISIRLVKGAYWDYEM 312
Cdd:PLN02681  233 GVPLLIDAEYTSLQPAIDYITYDLAREfnkGKDRPIVYGTYQAYLKDARERLRLDLERSEREGVPLGAKLVRGAYLSLER 312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  313 IRSRQSGLPEPVWTMKAETDAAFERQARRIME---NSDvCHFACASHNIRSISAVIELARELAVS--DDRYEFQVLYGMA 387
Cdd:PLN02681  313 RLAASLGVPSPVHDTIQDTHACYNRCAEFLLEkasNGD-GEVMLATHNVESGELAAAKMNELGLHkgDPRVQFAQLLGMS 391
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 221564986  388 EPVRKAILNRTGRLRLYCPYGPMVPGMGYLVRRLLEN 424
Cdd:PLN02681  392 DNLSFGLGNAGFRVSKYLPYGPVEEVIPYLLRRAEEN 428
ALDH_PAD-PaaZ cd07127
Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida) ...
545-962 4.26e-18

Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Phenylacetic acid degradation (PAD) proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida) are putative aromatic ring cleavage enzymes of the aerobic PA catabolic pathway. PaaZ mutants were defective for growth with PA as a sole carbon source due to interruption of the putative ring opening system. This CD is limited to bacterial monofunctional enzymes.


Pssm-ID: 143445  Cd Length: 549  Bit Score: 89.07  E-value: 4.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  545 EVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLEIGKQWDQAY-ADVTEAID----FLEYYAREM 619
Cdd:cd07127    85 DPDALLAAARAAMPGWRDAGARARAGVCLEILQRLNARSFEMAHAVMHTTGQAFMMAFqAGGPHAQDrgleAVAYAWREM 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  620 IRLGSPRSMGKVAGETNQYFYE------PKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFR 693
Cdd:cd07127   165 SRIPPTAEWEKPQGKHDPLAMEktftvvPRGVALVIGCSTFPTWNGYPGLFASLATGNPVIVKPHPAAILPLAITVQVAR 244
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  694 EV----GL-PDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAKVQpgqemvkkVICEMGGKNAIIIDD 768
Cdd:cd07127   245 EVlaeaGFdPNLVTLAADTPEEPIAQTLATRPEVRIIDFTGSNAFGDWLEANARQAQ--------VYTEKAGVNTVVVDS 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  769 DADLDEAVPHVFNSAFGFQGQKCSACSRVIV-LDGI--------YDKFVQrltALAEAVPvGPVEDPA---NLIGAVAEE 836
Cdd:cd07127   317 TDDLKAMLRNLAFSLSLYSGQMCTTPQNIYVpRDGIqtddgrksFDEVAA---DLAAAID-GLLADPAraaALLGAIQSP 392
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  837 NAQKRimnyIEVGRQEGRLLYQGHV------PEVGFFVPLTIIGDIRPEHRLAQEEiFGPLLAVMRARDFNEALVWANS- 909
Cdd:cd07127   393 DTLAR----IAEARQLGEVLLASEAvahpefPDARVRTPLLLKLDASDEAAYAEER-FGPIAFVVATDSTDHSIELAREs 467
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 221564986  910 --TRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQP--FGGFRLSGA 962
Cdd:cd07127   468 vrEHGAMTVGVYSTDPEVVERVQEAALDAGVALSINLTGGVFVNQSaaFSDFHGTGA 524
ALDH_KGSADH cd07129
Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Alpha-Ketoglutaric Semialdehyde (KGSA) ...
546-916 7.26e-18

Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Alpha-Ketoglutaric Semialdehyde (KGSA) Dehydrogenase (KGSADH, EC 1.2.1.26) catalyzes the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. This CD contains such sequences as those seen in Azospirillum brasilense, KGSADH-II (D-glucarate/D-galactarate-inducible) and KGSADH-III (hydroxy-L-proline-inducible). Both show similar high substrate specificity for KGSA and different coenzyme specificity; KGSADH-II is NAD+-dependent and KGSADH-III is NADP+-dependent. Also included in this CD is the NADP(+)-dependent aldehyde dehydrogenase from Vibrio harveyi which catalyzes the oxidation of long-chain aliphatic aldehydes to acids.


Pssm-ID: 143447 [Multi-domain]  Cd Length: 454  Bit Score: 87.60  E-value: 7.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  546 VAQAIGAARKSFETWRDITPEIRAEFLlkactvvrrriyelsalqvleigkqwdQAYADVTEAI--DFLEYYAREMiRLG 623
Cdd:cd07129     1 VDAAAAAAAAAFESYRALSPARRAAFL---------------------------EAIADEIEALgdELVARAHAET-GLP 52
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  624 SPRSMGKVAGETNQ-----------YFYE-----------------------PKGVAAVIAPWNFPLAISM--GMVSAAI 667
Cdd:cd07129    53 EARLQGELGRTTGQlrlfadlvregSWLDaridpadpdrqplprpdlrrmlvPLGPVAVFGASNFPLAFSVagGDTASAL 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  668 VTGNCVVFK--PS--GLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVGLRIIERAAK 743
Cdd:cd07129   133 AAGCPVVVKahPAhpGTSELVARAIRAALRATGLPAGVFSLLQGGGREVGVALVKHPAIKAVGFTGSRRGGRALFDAAAA 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  744 -VQPgqemvKKVICEMGGKNaiiidddadldeavPHVFNSAF----------GF-------QGQKCSACSRVIVLDGI-Y 804
Cdd:cd07129   213 rPEP-----IPFYAELGSVN--------------PVFILPGAlaergeaiaqGFvgsltlgAGQFCTNPGLVLVPAGPaG 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  805 DKFVQRLTALAEAVPVGPVEDPAnliGAVAEENAQKRImnyieVGRQEGRLLYQGHVPEVGFFVP---LTIIGDIRPEHR 881
Cdd:cd07129   274 DAFIAALAEALAAAPAQTMLTPG---IAEAYRQGVEAL-----AAAPGVRVLAGGAAAEGGNQAAptlFKVDAAAFLADP 345
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 221564986  882 LAQEEIFGPLLAVMRARDFNEALVWANSTRYALTG 916
Cdd:cd07129   346 ALQEEVFGPASLVVRYDDAAELLAVAEALEGQLTA 380
ALDH_F3FHI cd07137
Plant aldehyde dehydrogenase family 3 members F1, H1, and I1 and related proteins; Aldehyde ...
637-967 2.10e-17

Plant aldehyde dehydrogenase family 3 members F1, H1, and I1 and related proteins; Aldehyde dehydrogenase family members 3F1, 3H1, and 3I1 (ALDH3F1, ALDH3H1, and ALDH3I1), and similar plant sequences, are in this CD. In Arabidopsis thaliana, stress-regulated expression of ALDH3I1 was observed in leaves and osmotic stress expression of ALDH3H1 was observed in root tissue, whereas, ALDH3F1 expression was not stress responsive. Functional analysis of ALDH3I1 suggest it may be involved in a detoxification pathway in plants that limits aldehyde accumulation and oxidative stress.


Pssm-ID: 143455 [Multi-domain]  Cd Length: 432  Bit Score: 85.93  E-value: 2.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  637 QYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVgLPDGVFNFVPGrSGIMGDYL 716
Cdd:cd07137    96 EIVSEPLGVVLVISAWNFPFLLSLEPVIGAIAAGNAVVLKPSELAPATSALLAKLIPEY-LDTKAIKVIEG-GVPETTAL 173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  717 VDHpHVSLIAFTGSMEVGlRIIERAAKvqpgqEMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGF-QGQKCSACS 795
Cdd:cd07137   174 LEQ-KWDKIFFTGSPRVG-RIIMAAAA-----KHLTPVTLELGGKCPVIVDSTVDLKVAVRRIAGGKWGCnNGQACIAPD 246
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  796 RVIVLDGIYDKFVQRLTALAEAVpVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEVGFFVPLTIIGD 875
Cdd:cd07137   247 YVLVEESFAPTLIDALKNTLEKF-FGENPKESKDLSRIVNSHHFQRLSRLLDDPSVADKIVHGGERDEKNLYIEPTILLD 325
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  876 IRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEhiaiATKRFR----VGNLYLNRNCTGALVGR 951
Cdd:cd07137   326 PPLDSSIMTEEIFGPLLPIITVKKIEESIEIINSRPKPLAAYVFTKNKE----LKRRIVaetsSGGVTFNDTVVQYAIDT 401
                         330
                  ....*....|....*.
gi 221564986  952 QPFGGFRLSGAGTKAG 967
Cdd:cd07137   402 LPFGGVGESGFGAYHG 417
PRK11903 PRK11903
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase;
604-927 2.35e-17

3,4-dehydroadipyl-CoA semialdehyde dehydrogenase;


Pssm-ID: 237016 [Multi-domain]  Cd Length: 521  Bit Score: 86.68  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  604 DVTEAIDFLEYYAR--------EMIRLGSPRSMGKVAGETNQYFYEP-KGVAAVIAPWNFPlaiSMGM---VSAAIVTGN 671
Cdd:PRK11903  101 DIDGGIFTLGYYAKlgaalgdaRLLRDGEAVQLGKDPAFQGQHVLVPtRGVALFINAFNFP---AWGLwekAAPALLAGV 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  672 CVVFKPSGLTSIIGWQLVDIFREVG-LPDGVFNFVPGRSGIMGDYLVDHPHVSliaFTGSMEVGLRI------IERAAKV 744
Cdd:PRK11903  178 PVIVKPATATAWLTQRMVKDVVAAGiLPAGALSVVCGSSAGLLDHLQPFDVVS---FTGSAETAAVLrshpavVQRSVRV 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  745 ----------------QPGQE----MVKKVICEMGGKNaiiidddadldeavphvfnsafgfqGQKCSACSRVIVLDGIY 804
Cdd:PRK11903  255 nveadslnsallgpdaAPGSEafdlFVKEVVREMTVKS-------------------------GQKCTAIRRIFVPEALY 309
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  805 DKFVQRLTALAEAVPVGpveDPAN---LIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHV-------PEVGFFVPLTIIG 874
Cdd:PRK11903  310 DAVAEALAARLAKTTVG---NPRNdgvRMGPLVSRAQLAAVRAGLAALRAQAEVLFDGGGfalvdadPAVAACVGPTLLG 386
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 221564986  875 --DIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIA 927
Cdd:PRK11903  387 asDPDAATAVHDVEVFGPVATLLPYRDAAHALALARRGQGSLVASVYSDDAAFLA 441
ALDH_MaoC-N cd07128
N-terminal domain of the monoamine oxidase C dehydratase; The N-terminal domain of the MaoC ...
511-976 2.35e-17

N-terminal domain of the monoamine oxidase C dehydratase; The N-terminal domain of the MaoC dehydratase, a monoamine oxidase regulatory protein. Orthologs of MaoC include PaaZ (Escherichia coli) and PaaN (Pseudomonas putida), which are putative ring-opening enzymes of the aerobic phenylacetic acid (PA) catabolic pathway. The C-terminal domain of MaoC has sequence similarity to enoyl-CoA hydratase. Also included in this CD is a novel Burkholderia xenovorans LB400 ALDH of the aerobic benzoate oxidation (box) pathway. This pathway involves first the synthesis of a CoA thio-esterified aromatic acid, with subsequent dihydroxylation and cleavage steps, yielding the CoA thio-esterified aliphatic aldehyde, 3,4-dehydroadipyl-CoA semialdehyde, which is further converted into its corresponding CoA acid by the Burkholderia LB400 ALDH.


Pssm-ID: 143446 [Multi-domain]  Cd Length: 513  Bit Score: 86.55  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  511 FIGGQELE-TEDLLPSMNPSDpSEIVGWVCQAGTDeVAQAIGAAR-KSFETWRDITPEIRAEFLLKACTVVRRRIYELSA 588
Cdd:cd07128     4 YVAGQWHAgTGDGRTLHDAVT-GEVVARVSSEGLD-FAAAVAYAReKGGPALRALTFHERAAMLKALAKYLMERKEDLYA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  589 LQVLEIGKQWDQAYaDVTEAIDFLEYYA----REM-----IRLGSPRSMGKVAGETNQYFYEPK-GVAAVIAPWNFPlai 658
Cdd:cd07128    82 LSAATGATRRDSWI-DIDGGIGTLFAYAslgrRELpnahfLVEGDVEPLSKDGTFVGQHILTPRrGVAVHINAFNFP--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  659 SMGMVSAAIVT---GNCVVFKPSGLTSIIGWQLVDIFREVG-LPDGVFNFVPGRSGIMGDYLVDHPHVsliAFTGSMEVG 734
Cdd:cd07128   158 VWGMLEKFAPAllaGVPVIVKPATATAYLTEAVVKDIVESGlLPEGALQLICGSVGDLLDHLGEQDVV---AFTGSAATA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  735 LR------IIER----------------AAKVQPGQE----MVKKVICEMGGKnaiiidddadldeavphvfnsafgfQG 788
Cdd:cd07128   235 AKlrahpnIVARsirfnaeadslnaailGPDATPGTPefdlFVKEVAREMTVK-------------------------AG 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  789 QKCSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQKRIMNYIEVGRQEGRLLY--------QGH 860
Cdd:cd07128   290 QKCTAIRRAFVPEARVDAVIEALKARLAKVVVGDPRLEGVRMGPLVSREQREDVRAAVATLLAEAEVVFggpdrfevVGA 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  861 VPEVGFFVPLTII--GDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIA-----IATKRF 933
Cdd:cd07128   370 DAEKGAFFPPTLLlcDDPDAATAVHDVEAFGPVATLMPYDSLAEAIELAARGRGSLVASVVTNDPAFARelvlgAAPYHG 449
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 221564986  934 RVgnLYLNRNCTGALVGR-QPF-----GGFRLSGAGTKAGGPDYLLHFM 976
Cdd:cd07128   450 RL--LVLNRDSAKESTGHgSPLpqlvhGGPGRAGGGEELGGLRGVKHYM 496
ALDH_F12_P5CDH cd07126
Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH family 12; Delta(1) ...
596-905 8.13e-16

Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH family 12; Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, EC=1.5.1.12), family 12: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. P5CDH is a mitochondrial enzyme involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. The P5CDH, ALDH12A1 gene, in Arabidopsis, has been identified as an osmotic-stress-inducible ALDH gene. This CD contains both Viridiplantae and Alveolata P5CDH sequences.


Pssm-ID: 143444  Cd Length: 489  Bit Score: 81.39  E-value: 8.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  596 KQWDQAYADVTEAIDFLEYYAREMIRLGSpRSM---GKVAGETNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNC 672
Cdd:cd07126    94 KSDAQALGEVVVTRKFLENFAGDQVRFLA-RSFnvpGDHQGQQSSGYRWPYGPVAIITPFNFPLEIPALQLMGALFMGNK 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  673 VVFKPSGLTSIIGWQLVDIFREVGLPDGVFNFVPGRSGIMGDYLVD-HPHVSLiaFTGSMevglRIIERAAKVQPGqemv 751
Cdd:cd07126   173 PLLKVDSKVSVVMEQFLRLLHLCGMPATDVDLIHSDGPTMNKILLEaNPRMTL--FTGSS----KVAERLALELHG---- 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  752 kKVICEMGGKNAIIIDDDADLDEAVPHVFNS-AFGFQGQKCSACSRVIVLDGIYDK-FVQRLTALA-----EAVPVGPVE 824
Cdd:cd07126   243 -KVKLEDAGFDWKILGPDVSDVDYVAWQCDQdAYACSGQKCSAQSILFAHENWVQAgILDKLKALAeqrklEDLTIGPVL 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  825 DPANligavaeenaqKRIMNYIE--VGRQEGRLLYQG------HVPEV-------GFFVPLTIIGDirPEH-RLAQEEIF 888
Cdd:cd07126   322 TWTT-----------ERILDHVDklLAIPGAKVLFGGkpltnhSIPSIygayeptAVFVPLEEIAI--EENfELVTTEVF 388
                         330
                  ....*....|....*..
gi 221564986  889 GPLLAVMRARDFNEALV 905
Cdd:cd07126   389 GPFQVVTEYKDEQLPLV 405
PLN02203 PLN02203
aldehyde dehydrogenase
635-909 1.82e-12

aldehyde dehydrogenase


Pssm-ID: 165847 [Multi-domain]  Cd Length: 484  Bit Score: 70.91  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  635 TNQYFYEPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVgLPDGVFNFVPGRSGImGD 714
Cdd:PLN02203  101 TAEVVPEPLGVVLIFSSWNFPIGLSLEPLIGAIAAGNAVVLKPSELAPATSAFLAANIPKY-LDSKAVKVIEGGPAV-GE 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  715 YLVDHPHvSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKN---AIIIDDDADLDEAVPHVFNSAFGF-QGQK 790
Cdd:PLN02203  179 QLLQHKW-DKIFFTGSPRVGRIIMTAAAK------HLTPVALELGGKCpciVDSLSSSRDTKVAVNRIVGGKWGScAGQA 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  791 CSACSRVIVLDGIYDKFVQRLTALAEAVPVGPVEDPANLIGAVAEENAQkRIMNYIEVGRQEGRLLYQGHVPEVGFFVPL 870
Cdd:PLN02203  252 CIAIDYVLVEERFAPILIELLKSTIKKFFGENPRESKSMARILNKKHFQ-RLSNLLKDPRVAASIVHGGSIDEKKLFIEP 330
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 221564986  871 TIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWANS 909
Cdd:PLN02203  331 TILLNPPLDSDIMTEEIFGPLLPIITVKKIEDSIAFINS 369
PLN02174 PLN02174
aldehyde dehydrogenase family 3 member H1
641-967 1.30e-11

aldehyde dehydrogenase family 3 member H1


Pssm-ID: 177831  Cd Length: 484  Bit Score: 68.15  E-value: 1.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  641 EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREVgLPDGVFNFVPGrsGIMGDYLVDHP 720
Cdd:PLN02174  111 EPLGVVLVISAWNYPFLLSIDPVIGAISAGNAVVLKPSELAPASSALLAKLLEQY-LDSSAVRVVEG--AVTETTALLEQ 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  721 HVSLIAFTGSMEVGLRIIERAAKvqpgqeMVKKVICEMGGKNAIIIDDDADLDEAVPHVFNSAFGF-QGQKCSACSRVIV 799
Cdd:PLN02174  188 KWDKIFYTGSSKIGRVIMAAAAK------HLTPVVLELGGKSPVVVDSDTDLKVTVRRIIAGKWGCnNGQACISPDYILT 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  800 LDGIYDKFVQRLT-ALAEAVPVGPVEdpANLIGAVAEENAQKRIMNYIEVGRQEGRLLYQGHVPEVGFFVPLTIIGDIRP 878
Cdd:PLN02174  262 TKEYAPKVIDAMKkELETFYGKNPME--SKDMSRIVNSTHFDRLSKLLDEKEVSDKIVYGGEKDRENLKIAPTILLDVPL 339
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  879 EHRLAQEEIFGPLLAVMRARDFNEALVWANSTRYALTGGLFSRSPEHIAIATKRFRVGNLYLNRNCTGALVGRQPFGGFR 958
Cdd:PLN02174  340 DSLIMSEEIFGPLLPILTLNNLEESFDVIRSRPKPLAAYLFTHNKKLKERFAATVSAGGIVVNDIAVHLALHTLPFGGVG 419

                  ....*....
gi 221564986  959 LSGAGTKAG 967
Cdd:PLN02174  420 ESGMGAYHG 428
ALDH_EutE cd07121
Ethanolamine utilization protein EutE-like; Coenzyme A acylating aldehyde dehydrogenase (ACDH), ...
544-907 2.92e-06

Ethanolamine utilization protein EutE-like; Coenzyme A acylating aldehyde dehydrogenase (ACDH), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, acetylating (EC=1.2.1.10), converts acetaldehyde into acetyl-CoA. This CD is limited to such monofunctional enzymes as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium. Mutations in eutE abolish the ability to utilize ethanolamine as a carbon source.


Pssm-ID: 143439 [Multi-domain]  Cd Length: 429  Bit Score: 50.70  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  544 DEVAQAIGAARKSFETWRDITPEIRAEFLLKACTVVRRRIYELSALQVLE--IGKQWDQ-----AYADVTEAIDFLEyya 616
Cdd:cd07121     4 ATVDDAVAAAKAAQKQYRKCTLADREKIIEAIREALLSNAEELAEMAVEEtgMGRVEDKiaknhLAAEKTPGTEDLT--- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  617 remirlgsPRSMGKVAGETnQYFYEPKGVAAVIAPWNFPLAI----SMGMVSAaivtGNCVVFKP---SGLTSIIGWQLV 689
Cdd:cd07121    81 --------TTAWSGDNGLT-LVEYAPFGVIGAITPSTNPTETiinnSISMLAA----GNAVVFNPhpgAKKVSAYAVELI 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  690 -DIFREVGLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGsmevGLRIIERAAKVQpgqemvKKVICEmGGKNAIIIDD 768
Cdd:cd07121   148 nKAIAEAGGPDNLVVTVEEPTIETTNELMAHPDINLLVVTG----GPAVVKAALSSG------KKAIGA-GAGNPPVVVD 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  769 DADLDEAVPH--VFNSAFGfQGQKCSACSRVIVLDGIYDKFVQRLTAlAEAVPVGPVEDPANLIGAVAEENAQkrIMNYI 846
Cdd:cd07121   217 ETADIEKAARdiVQGASFD-NNLPCIAEKEVIAVDSVADYLIAAMQR-NGAYVLNDEQAEQLLEVVLLTNKGA--TPNKK 292
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221564986  847 EVGRQEGRLLYQGHVpEVGFFVPLtIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWA 907
Cdd:cd07121   293 WVGKDASKILKAAGI-EVPADIRL-IIVETDKDHPFVVEEQMMPILPVVRVKNFDEAIELA 351
ALDH_F20_ACDH_EutE-like cd07081
Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and ...
641-918 1.09e-05

Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Coenzyme A acylating aldehyde dehydrogenase (ACDH), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, acetylating (EC=1.2.1.10), functions as a single enzyme (such as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium) or as part of a multifunctional enzyme to convert acetaldehyde into acetyl-CoA. The E. coli aldehyde-alcohol dehydrogenase includes the functional domains, alcohol dehydrogenase (ADH), ACDH, and pyruvate-formate-lyase deactivase; and the Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 (ALDH20A1) includes the functional domains ADH and ACDH, and may be critical enzymes in the fermentative pathway.


Pssm-ID: 143400 [Multi-domain]  Cd Length: 439  Bit Score: 49.19  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  641 EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFKPSGLTSIIGWQLVDIFREV----GLPDGVFNFVPGRSGIMGDYL 716
Cdd:cd07081    94 EPIGVVASITPSTNPTSTVIFKSLISLKTRNSIIFSPHPRAKKVTQRAATLLLQAavaaGAPENLIGWIDNPSIELAQRL 173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  717 VDHPHVSLIAFTGS---MEVGLRIIERAAKVQPGQEMVkkVICEMGgknaiiidddaDLDEAVPHVFNSAFGFQGQKCSA 793
Cdd:cd07081   174 MKFPGIGLLLATGGpavVKAAYSSGKPAIGVGAGNTPV--VIDETA-----------DIKRAVQSIVKSKTFDNGVICAS 240
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  794 CSRVIVLDGIYDKfVQRLTALAEAVPVgpvedPANLIGAVAEENAQKRIMNYIEVGRQEGRLlyqghVPEVGFFVPLT-- 871
Cdd:cd07081   241 EQSVIVVDSVYDE-VMRLFEGQGAYKL-----TAEELQQVQPVILKNGDVNRDIVGQDAYKI-----AAAAGLKVPQEtr 309
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 221564986  872 -IIGDIRP--EHRLAQEEIFGPLLAVMRARDFNEALvwANSTRYALTGGL 918
Cdd:cd07081   310 iLIGEVTSlaEHEPFAHEKLSPVLAMYRAANFADAD--AKALALKLEGGC 357
ALDH_F20_ACDH cd07122
Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Coenzyme A acylating ...
641-935 7.05e-05

Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Coenzyme A acylating aldehyde dehydrogenase (ACDH, EC=1.2.1.10), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, functions as a single enzyme (such as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium) or as part of a multifunctional enzyme to convert acetaldehyde into acetyl-CoA . The E. coli aldehyde-alcohol dehydrogenase includes the functional domains, alcohol dehydrogenase (ADH), ACDH, and pyruvate-formate-lyase deactivase; and the Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 (ALDH20A1) includes the functional domains ADH and ACDH and may be critical enzymes in the fermentative pathway.


Pssm-ID: 143440 [Multi-domain]  Cd Length: 436  Bit Score: 46.33  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  641 EPKGVAAVIAPWNFPLAISMGMVSAAIVTGNCVVFK--PSGLTSIIgwQLVDIFRE----VGLPDGVFNFVPGRSGIMGD 714
Cdd:cd07122    94 EPVGVIAALIPSTNPTSTAIFKALIALKTRNAIIFSphPRAKKCSI--EAAKIMREaavaAGAPEGLIQWIEEPSIELTQ 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  715 YLVDHPHVSLIAFTGSME--------------VGL----RIIERAAKVQpgqEMVKKVIcemggknaiiidddadldeav 776
Cdd:cd07122   172 ELMKHPDVDLILATGGPGmvkaayssgkpaigVGPgnvpAYIDETADIK---RAVKDII--------------------- 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  777 phvFNSAFGFqGQKCSACSRVIVLDGIYDKFVQRLTALAeavpvgpvedpanliGAVAEENAQKRIMNYIE--------- 847
Cdd:cd07122   228 ---LSKTFDN-GTICASEQSVIVDDEIYDEVRAELKRRG---------------AYFLNEEEKEKLEKALFddggtlnpd 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  848 -VGRQEGRLLYQghvpeVGFFVPLTI------IGDIRPEHRLAQEEIFgPLLAVMRARDFNEALVWANS-TRYA---LTG 916
Cdd:cd07122   289 iVGKSAQKIAEL-----AGIEVPEDTkvlvaeETGVGPEEPLSREKLS-PVLAFYRAEDFEEALEKARElLEYGgagHTA 362
                         330       340
                  ....*....|....*....|..
gi 221564986  917 GLFSRSPEHI---AIATKRFRV 935
Cdd:cd07122   363 VIHSNDEEVIeefALRMPVSRI 384
ALDH-like cd07077
NAD(P)+-dependent aldehyde dehydrogenase-like (ALDH-like) family; The aldehyde ...
622-903 2.37e-04

NAD(P)+-dependent aldehyde dehydrogenase-like (ALDH-like) family; The aldehyde dehydrogenase-like (ALDH-like) group of the ALDH superfamily of NAD(P)+-dependent enzymes which, in general, oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an important role in detoxification. This group includes families ALDH18, ALDH19, and ALDH20 and represents such proteins as gamma-glutamyl phosphate reductase, LuxC-like acyl-CoA reductase, and coenzyme A acylating aldehyde dehydrogenase. All of these proteins have a conserved cysteine that aligns with the catalytic cysteine of the ALDH group.


Pssm-ID: 143396 [Multi-domain]  Cd Length: 397  Bit Score: 44.52  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  622 LGSPRSMGKVAGETNQYFYE------PKGVAAVIAPWNFPLAISMGMVSAaIVTGNCVVFKPSGLTSIIGWQLVDIFREV 695
Cdd:cd07077    74 RGITASVGHIQDVLLPDNGEtyvrafPIGVTMHILPSTNPLSGITSALRG-IATRNQCIFRPHPSAPFTNRALALLFQAA 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  696 ---GLPDGVFNFVPGRSGIMGDYLVDHPHVSLIAFTGSMEVglriIERAAKVQPGqemvKKVICEMGGKNAIIIDDDADL 772
Cdd:cd07077   153 daaHGPKILVLYVPHPSDELAEELLSHPKIDLIVATGGRDA----VDAAVKHSPH----IPVIGFGAGNSPVVVDETADE 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  773 DEAVPHVFNSAFgFQGQKCSACSRVIVLDGIYDKFVQRltalaeavpvgpvedpanligavaeenaqkrimnYIEVGRQE 852
Cdd:cd07077   225 ERASGSVHDSKF-FDQNACASEQNLYVVDDVLDPLYEE----------------------------------FKLKLVVE 269
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 221564986  853 GRLLYQGhvpevgffvPLTIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEA 903
Cdd:cd07077   270 GLKVPQE---------TKPLSKETTPSFDDEALESMTPLECQFRVLDVISA 311
PRK15398 PRK15398
aldehyde dehydrogenase;
791-907 1.07e-03

aldehyde dehydrogenase;


Pssm-ID: 237956  Cd Length: 465  Bit Score: 42.58  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221564986  791 CSACSRVIVLDGIYDKFVQRLTAlAEAVPVGPvEDPANLIGAVAEEN--AQKRImnyieVGRQEGRLLYQGHVpEVGFFV 868
Cdd:PRK15398  272 CIAEKEVIVVDSVADELMRLMEK-NGAVLLTA-EQAEKLQKVVLKNGgtVNKKW-----VGKDAAKILEAAGI-NVPKDT 343
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 221564986  869 PLtIIGDIRPEHRLAQEEIFGPLLAVMRARDFNEALVWA 907
Cdd:PRK15398  344 RL-LIVETDANHPFVVTELMMPVLPVVRVKDVDEAIALA 381
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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