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Conserved domains on  [gi|186911199|gb|ACC94724|]
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ATPase 6, partial (mitochondrion) [Drosophila ornatifrons]

Protein Classification

ATP synthase F0 subunit 6( domain architecture ID 10009593)

ATP synthase F0 subunit 6 is part of the mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V), which produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATP6 MTH00157
ATP synthase F0 subunit 6; Provisional
 2-117 3.00e-50

ATP synthase F0 subunit 6; Provisional


:

Pssm-ID: 214441  Cd Length: 223  Bit Score: 158.41  E-value: 3.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   2 FNLSLNWLSTFLGLLMIPSIYWLMPSRYNIFWNSILLTLHKEFKTLLGPSSKnGSTFIFISLFSLILFNNFMGLFPYIFT 81
Cdd:MTH00157  15 FNLSLNWLSTFLGLLFIPSSFWLIPSRYNILWNKILKTLHKEFKTLLGPKNK-GSTLIFISLFSFILFNNFLGLFPYIFT 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 186911199  82 STSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:MTH00157  94 STSHLSLTLSLALPLWLSFMLFGWINNTNHMFAHLV 129
 
Name Accession Description Interval E-value
ATP6 MTH00157
ATP synthase F0 subunit 6; Provisional
 2-117 3.00e-50

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214441  Cd Length: 223  Bit Score: 158.41  E-value: 3.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   2 FNLSLNWLSTFLGLLMIPSIYWLMPSRYNIFWNSILLTLHKEFKTLLGPSSKnGSTFIFISLFSLILFNNFMGLFPYIFT 81
Cdd:MTH00157  15 FNLSLNWLSTFLGLLFIPSSFWLIPSRYNILWNKILKTLHKEFKTLLGPKNK-GSTLIFISLFSFILFNNFLGLFPYIFT 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 186911199  82 STSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:MTH00157  94 STSHLSLTLSLALPLWLSFMLFGWINNTNHMFAHLV 129
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 1-117 1.23e-18

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 77.25  E-value: 1.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199    1 IFNLSLNWLSTFLGLLMI----PSIYWLMPSRYNIFWNSILLTLHKEFKTLLGPSSKNGSTFIFiSLFSLILFNNFMGLF 76
Cdd:TIGR01131  12 LFSLTLLSLILLLSLLIFlissSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKKGKFFPLIF-TLFLFILISNLLGLI 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 186911199   77 PYIFTSTSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:TIGR01131  91 PYSFTPTSHLSFTLGLALPLWLGLTISGFRKHPKGFLAHLV 131
ATP-synt_A pfam00119
ATP synthase A chain;
8-108 3.64e-07

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 46.33  E-value: 3.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199    8 WLSTFLGLLMIPSIYW----LMPSRYNIFWNSILLTLHKEFKTLLGPSSKNGSTFIFISLFSLILFNNFMGLF---PYIF 80
Cdd:pfam00119   5 LIVALILLLFLLLATRktkkLVPGRLQNFVEMLVEFVDNIVKDNIGKKKGRKFFPLLLTLFFFILVSNLLGLIpksPGGF 84

                          90       100
                  ....*....|....*....|....*...
gi 186911199   81 TSTSHLTLTLSLALPLWLSFMIYGWINH 108
Cdd:pfam00119  85 TVTADINVTLALALIVFLLVHYYGIKKH 112
 
Name Accession Description Interval E-value
ATP6 MTH00157
ATP synthase F0 subunit 6; Provisional
 2-117 3.00e-50

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214441  Cd Length: 223  Bit Score: 158.41  E-value: 3.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   2 FNLSLNWLSTFLGLLMIPSIYWLMPSRYNIFWNSILLTLHKEFKTLLGPSSKnGSTFIFISLFSLILFNNFMGLFPYIFT 81
Cdd:MTH00157  15 FNLSLNWLSTFLGLLFIPSSFWLIPSRYNILWNKILKTLHKEFKTLLGPKNK-GSTLIFISLFSFILFNNFLGLFPYIFT 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 186911199  82 STSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:MTH00157  94 STSHLSLTLSLALPLWLSFMLFGWINNTNHMFAHLV 129
ATP6 MTH00176
ATP synthase F0 subunit 6; Provisional
 5-117 4.64e-20

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214449  Cd Length: 229  Bit Score: 81.23  E-value: 4.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   5 SLNWLSTFLGLLMIPSIYWLMPSRYNIFWNsILLTLHKEFKTLLGPSSKNGSTFIFISLFSLILFNNFMGLFPYIFTSTS 84
Cdd:MTH00176  21 SLSWITLLLFLLLMPSSVWFCPSKLQVFML-MFSTFLPEMILRSNGSYILGSASIIISLFILVMSLNLSGLIPYVFTSTS 99

                         90       100       110
                 ....*....|....*....|....*....|...
gi 186911199  85 HLTLTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:MTH00176 100 HLVITLSLALPLWLGVILSGFINNFYSRLSHLV 132
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 1-117 1.23e-18

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 77.25  E-value: 1.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199    1 IFNLSLNWLSTFLGLLMI----PSIYWLMPSRYNIFWNSILLTLHKEFKTLLGPSSKNGSTFIFiSLFSLILFNNFMGLF 76
Cdd:TIGR01131  12 LFSLTLLSLILLLSLLIFlissSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKKGKFFPLIF-TLFLFILISNLLGLI 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 186911199   77 PYIFTSTSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:TIGR01131  91 PYSFTPTSHLSFTLGLALPLWLGLTISGFRKHPKGFLAHLV 131
ATP6 MTH00005
ATP synthase F0 subunit 6; Provisional
 5-117 7.58e-14

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 164583  Cd Length: 231  Bit Score: 64.75  E-value: 7.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   5 SLNWLSTFLGLLMIPSIYWLMPSRYNIFWNSILLTLHKEFKTLLGPSSKNGSTFIfISLFSLILFNNFMGLFPYIFTSTS 84
Cdd:MTH00005  23 TAFWAFNFSIILLLSSSFWITPNRLSSIMSPPKSTMHTQLSRTFGKHLKGFSSLI-SALFTMIILMNLSGLLPYVFSTSS 101

                         90       100       110
                 ....*....|....*....|....*....|...
gi 186911199  85 HLTLTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:MTH00005 102 HLIFTLTLGLPLWLSLIMSSVTFSPKKFAAHLL 134
ATP6 MTH00173
ATP synthase F0 subunit 6; Provisional
 8-117 7.14e-13

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214448  Cd Length: 231  Bit Score: 62.19  E-value: 7.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   8 WLSTFLGLLMIPSIYWLMPSRYNIFWNSILLTLHKEFKTLLGpSSKNGSTFIFISLFSLILFNNFMGLFPYIFTSTSHLT 87
Cdd:MTH00173  24 WLLSLMSLFFFSSSVWVSSSNLSSVFKLFVLTVSSQVTRSSG-LNLGGFSLLLSSLFLFLISLNLSGLLPFVFSVTSHLA 102

                         90       100       110
                 ....*....|....*....|....*....|
gi 186911199  88 LTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:MTH00173 103 FTFSLALPLWLSLILSGLFYNPSKSLAGLV 132
ATP6 MTH00035
ATP synthase F0 subunit 6; Validated
 1-117 1.11e-11

ATP synthase F0 subunit 6; Validated


Pssm-ID: 177110  Cd Length: 229  Bit Score: 58.83  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   1 IFNLSLNWLSTFLGL---LMIPSIYWLmPSRYNIFWNSILLTLhkeFKTLLGPSSKNGSTFI--FISLFSLILFNNFMGL 75
Cdd:MTH00035  16 ILFIPLTLLSSVIALswlFFINPTNWL-PSRSQSIWLTFRQEI---LKLIFQNTNPNTAPWAglLTTVFILILSINVLGL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 186911199  76 FPYIFTSTSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHLV 117
Cdd:MTH00035  92 FPYAFTSTSHISLTYSLGIPLWMSVNILGFYLAFNSRLSHLV 133
ATP6 MTH00120
ATP synthase F0 subunit 6; Provisional
 9-116 1.44e-10

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177181  Cd Length: 227  Bit Score: 55.99  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   9 LSTFLGLLMIPSIYWLMPS---RYNIFWNSILLTLHKEFKTLLGPSSKNGS--TFIFISLFSLILFNNFMGLFPYIFTST 83
Cdd:MTH00120  17 IPLILLAMLIPALLIPSPKnrlLTNRLTTLQLWLIKLITKQLMLPLNKKGHkwALILTSLMLLLLLINLLGLLPYTFTPT 96

                         90       100       110
                 ....*....|....*....|....*....|...
gi 186911199  84 SHLTLTLSLALPLWLSFMIYGWINHTQHMFAHL 116
Cdd:MTH00120  97 TQLSMNMALAIPLWLATVLTGLRNQPTTSLAHL 129
ATP6 MTH00179
ATP synthase F0 subunit 6; Provisional
 4-116 8.94e-10

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177230  Cd Length: 227  Bit Score: 53.80  E-value: 8.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   4 LSLNWLSTFLGLLMIPSIYWLMPSRYNIFWNSILLTLHKEF-----KTLLGPSSKNGSTF--IFISLFSLILFNNFMGLF 76
Cdd:MTH00179  10 ESPSLLGIPLLALALLLPWLLFPSLTNRWLNNRLSTLQSWFfgsftFQLMQPINKKGHKWavLFLSLMLFLLTLNLLGLL 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 186911199  77 PYIFTSTSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHL 116
Cdd:MTH00179  90 PYTFTPTTQLSLNLGLALPLWLGTVLYGLFNQPTIALAHL 129
ATP6 MTH00073
ATP synthase F0 subunit 6; Provisional
 40-116 2.88e-08

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177144  Cd Length: 227  Bit Score: 49.58  E-value: 2.88e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186911199  40 LHKEFKTLLGPSSKNGS--TFIFISLFSLILFNNFMGLFPYIFTSTSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHL 116
Cdd:MTH00073  51 LQNFTKQLMLPLNTPGHkwALILTSLMVFLITMNLLGLLPYTFTPTTQLSLNLGLAVPLWLATVLIGLRNQPTASLGHL 129
ATP6 MTH00132
ATP synthase F0 subunit 6; Provisional
 11-116 2.98e-08

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177190  Cd Length: 227  Bit Score: 49.49  E-value: 2.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199  11 TFLGLLMIP---SIYWLM-PSRYNIFWNSILLTLHKEF-----KTLLGPSSKNGSTF--IFISLFSLILFNNFMGLFPYI 79
Cdd:MTH00132  13 TYLGIPLIAlalTLPWILfPTPTSRWLNNRLLTLQGWFinrftQQLLLPLNVGGHKWalLLTSLMLFLITLNMLGLLPYT 92

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 186911199  80 FTSTSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHL 116
Cdd:MTH00132  93 FTPTTQLSLNMGLAVPLWLATVIIGMRNQPTHALGHL 129
ATP6 MTH00172
ATP synthase F0 subunit 6; Provisional
 1-104 3.29e-07

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214447  Cd Length: 232  Bit Score: 46.96  E-value: 3.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199   1 IFNLSLNWLSTFLGLLMIPSIYWLMPSRYNIFWNSILLTLHKEFKTLLGPSSKNGSTFIfISLFSLILFNNFMGLFPYIF 80
Cdd:MTH00172  17 LTNSSIMMILVIIVVLLLFKGIKLIPKRWQSIIEIIYNHFHGVVKDNLGNEGLKYFPFI-ISLFFFIVFLNLLGLFPYVF 95

                         90       100
                 ....*....|....*....|....
gi 186911199  81 TSTSHLTLTLSLALPLWLSFMIYG 104
Cdd:MTH00172  96 TPTTHIVVTLGLSFSIIIGVTLAG 119
ATP-synt_A pfam00119
ATP synthase A chain;
8-108 3.64e-07

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 46.33  E-value: 3.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199    8 WLSTFLGLLMIPSIYW----LMPSRYNIFWNSILLTLHKEFKTLLGPSSKNGSTFIFISLFSLILFNNFMGLF---PYIF 80
Cdd:pfam00119   5 LIVALILLLFLLLATRktkkLVPGRLQNFVEMLVEFVDNIVKDNIGKKKGRKFFPLLLTLFFFILVSNLLGLIpksPGGF 84

                          90       100
                  ....*....|....*....|....*...
gi 186911199   81 TSTSHLTLTLSLALPLWLSFMIYGWINH 108
Cdd:pfam00119  85 TVTADINVTLALALIVFLLVHYYGIKKH 112
ATP6 MTH00101
ATP synthase F0 subunit 6; Validated
 63-116 6.53e-06

ATP synthase F0 subunit 6; Validated


Pssm-ID: 177163  Cd Length: 226  Bit Score: 43.02  E-value: 6.53e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 186911199  63 LFSLILF---NNFMGLFPYIFTSTSHLTLTLSLALPLWLSFMIYGWINHTQHMFAHL 116
Cdd:MTH00101  72 LMSLILFigsTNLLGLLPHSFTPTTQLSMNLGMAIPLWAGTVITGFRNKTKASLAHF 128
ATP6 MTH00175
ATP synthase F0 subunit 6; Provisional
 23-107 4.02e-04

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177228  Cd Length: 244  Bit Score: 38.06  E-value: 4.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199  23 WLMPSRYNIFWNSILLTLHKEFKTLLGPSSKNGSTFIFiSLFSLILFNNFMGLFPYIFTSTSHLTLTLSLALPLWLSFMI 102
Cdd:MTH00175  50 KLIPNRWQSIMELIYLNIRSVVHDNLGKSGQKYFPFIL-SLFLFIAILNILGLFPYVFTPTAHIIITFGLSLSIIIAVTL 128


                 ....*
gi 186911199 103 YGWIN 107
Cdd:MTH00175 129 LGFLT 133
ATP6 MTH00174
ATP synthase F0 subunit 6; Provisional
 24-117 6.39e-04

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 133799  Cd Length: 252  Bit Score: 37.61  E-value: 6.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186911199  24 LMPSRYNIFWNSILLTLHKEFKTLLGPSSKNGSTFIfISLFSLILFNNFMGLFPYIFTSTSHLTLTLSLALPLWLSFMIY 103
Cdd:MTH00174  59 LVPNRILVGLELIYSHFYTVLKDNLGNKGGNYLAFV-LSLFILILFGNGLGLFPYVFTPTVHMVITLGLSFAIIVGTTLA 137

                         90
                 ....*....|....
gi 186911199 104 GWINHTQHMFAHLV 117
Cdd:MTH00174 138 GLITFRFNFFSILM 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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