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Conserved domains on  [gi|147736229|gb|ABQ47569|]
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galactokinase [Thermotoga petrophila RKU-1]

Protein Classification

galactokinase( domain architecture ID 11480056)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK03817 PRK03817
galactokinase; Provisional
 1-350 0e+00

galactokinase; Provisional


:

Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 566.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   1 MKVKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSDRFIFHSENVNE--TVEMEKIEKLNKWTDYISGVIASFEKR 78
Cdd:PRK03817   1 MKVKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSEKFIFYSENFNEekTFELDKLEKLNSWADYIKGVIWVLEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  79 GYRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHA 158
Cdd:PRK03817  81 GYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGKKDHA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 159 IFLDTMTLEYEYVPLRlEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKSFREVTKEDLERLSGTLRKRAQHVL 238
Cdd:PRK03817 161 IFLDTMTLEYEYVPFP-EDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEDLSKLPPLLRKRAGYVL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 239 EENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKeGILGARMVGGGFGGGVIVLSKKGAFG 318
Cdd:PRK03817 240 RENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGAGFGGSAIALVDKGKFE 318

                        330       340       350
                 ....*....|....*....|....*....|..
gi 147736229 319 KIKEELVESYKKHFGIDLTFHEIESSDGVQKI 350
Cdd:PRK03817 319 SIGEELLEEYKKRFGIDPKYFVVESSDGVRKI 350
 
Name Accession Description Interval E-value
PRK03817 PRK03817
galactokinase; Provisional
 1-350 0e+00

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 566.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   1 MKVKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSDRFIFHSENVNE--TVEMEKIEKLNKWTDYISGVIASFEKR 78
Cdd:PRK03817   1 MKVKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSEKFIFYSENFNEekTFELDKLEKLNSWADYIKGVIWVLEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  79 GYRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHA 158
Cdd:PRK03817  81 GYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGKKDHA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 159 IFLDTMTLEYEYVPLRlEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKSFREVTKEDLERLSGTLRKRAQHVL 238
Cdd:PRK03817 161 IFLDTMTLEYEYVPFP-EDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEDLSKLPPLLRKRAGYVL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 239 EENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKeGILGARMVGGGFGGGVIVLSKKGAFG 318
Cdd:PRK03817 240 RENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGAGFGGSAIALVDKGKFE 318

                        330       340       350
                 ....*....|....*....|....*....|..
gi 147736229 319 KIKEELVESYKKHFGIDLTFHEIESSDGVQKI 350
Cdd:PRK03817 319 SIGEELLEEYKKRFGIDPKYFVVESSDGVRKI 350
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
3-350 2.18e-164

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 463.86  E-value: 2.18e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   3 VKAPGRINIIGEHTDYNDGYVLPFAVNR--YVFLSIEGSDRFIFHSENVNETVEME----KIEKLNKWTDYISGVIASFE 76
Cdd:COG0153   21 FSAPGRVNLIGEHTDYNGGFVLPAAIDRgtYAAARPRDDRKVRVYSADFDEEVEFDlddlEPGEEDGWANYVRGVAWALQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  77 KRGYRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKD 156
Cdd:COG0153  101 ERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 157 HAIFLDTMTLEYEYVPLRLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKSFREVTKEDLERL-----SGTLR 231
Cdd:COG0153  181 HALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKSLRDVTLEDLEAArarlgDEVLR 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 232 KRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGILGARMVgggfgggVIVL 311
Cdd:COG0153  261 RRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAGVLGARMTgggfggcTIAL 340

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 147736229 312 SKKGAFGKIKEELVESYKKHFGIDLTFHEIESSDGVQKI 350
Cdd:COG0153  341 VPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 3-350 5.09e-92

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 280.17  E-value: 5.09e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229    3 VKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSDRFI--FHSENVNETVEMEKIE------KLNKWTDYISGVIAS 74
Cdd:TIGR00131  20 ARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNvrIYLANADNKFAERSLDlpldgsEVSDWANYFKGVLHV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   75 FEKRGYRVSP-VKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFG 153
Cdd:TIGR00131 100 AQERFNSFPLgADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAENHFVGVNCGIMDQAASVLG 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  154 KKDHAIFLDTMTLEYEYVPLRLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKS---FREVTKEDLER----- 225
Cdd:TIGR00131 180 KEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAATDkgaLRDFMNEYFARyiarl 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  226 --LSGTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGILGARMVGGG 303
Cdd:TIGR00131 260 tkMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAALVNGSGGSRMTGAG 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 147736229  304 FGGGVIVLSKKGAFGKIKEELVESYKKHFGIDLTFHEIESSDGVQKI 350
Cdd:TIGR00131 340 FGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGSC 386
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 86-154 4.32e-20

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 82.60  E-value: 4.32e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147736229   86 KISVSSNLPMGAGLSSSAALEVATAYAISEYFsfnvpKLELVKIAREAEVEFVGVRCGIMDQFTSAFGK 154
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELF-----GLPLAKLALEAEELAGGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
PRK03817 PRK03817
galactokinase; Provisional
 1-350 0e+00

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 566.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   1 MKVKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSDRFIFHSENVNE--TVEMEKIEKLNKWTDYISGVIASFEKR 78
Cdd:PRK03817   1 MKVKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSEKFIFYSENFNEekTFELDKLEKLNSWADYIKGVIWVLEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  79 GYRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHA 158
Cdd:PRK03817  81 GYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGKKDHA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 159 IFLDTMTLEYEYVPLRlEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKSFREVTKEDLERLSGTLRKRAQHVL 238
Cdd:PRK03817 161 IFLDTMTLEYEYVPFP-EDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEDLSKLPPLLRKRAGYVL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 239 EENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKeGILGARMVGGGFGGGVIVLSKKGAFG 318
Cdd:PRK03817 240 RENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGAGFGGSAIALVDKGKFE 318

                        330       340       350
                 ....*....|....*....|....*....|..
gi 147736229 319 KIKEELVESYKKHFGIDLTFHEIESSDGVQKI 350
Cdd:PRK03817 319 SIGEELLEEYKKRFGIDPKYFVVESSDGVRKI 350
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
3-350 2.18e-164

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 463.86  E-value: 2.18e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   3 VKAPGRINIIGEHTDYNDGYVLPFAVNR--YVFLSIEGSDRFIFHSENVNETVEME----KIEKLNKWTDYISGVIASFE 76
Cdd:COG0153   21 FSAPGRVNLIGEHTDYNGGFVLPAAIDRgtYAAARPRDDRKVRVYSADFDEEVEFDlddlEPGEEDGWANYVRGVAWALQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  77 KRGYRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKD 156
Cdd:COG0153  101 ERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 157 HAIFLDTMTLEYEYVPLRLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKSFREVTKEDLERL-----SGTLR 231
Cdd:COG0153  181 HALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKSLRDVTLEDLEAArarlgDEVLR 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 232 KRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGILGARMVgggfgggVIVL 311
Cdd:COG0153  261 RRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAGVLGARMTgggfggcTIAL 340

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 147736229 312 SKKGAFGKIKEELVESYKKHFGIDLTFHEIESSDGVQKI 350
Cdd:COG0153  341 VPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK05322 PRK05322
galactokinase; Provisional
 5-350 3.94e-114

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 336.44  E-value: 3.94e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   5 APGRINIIGEHTDYNDGYVLPFAVNRYVFLSI-EGSDRFI-FHSENVNETVEME------KIEKLNKWTDYISGVIASFE 76
Cdd:PRK05322  24 SPGRINLIGEHTDYNGGHVFPAAITLGTYGAArKRDDKKVrLYSANFEDLGIIEfdlddlSFDKEDDWANYPKGVLKFLQ 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  77 KRGYRVSP-VKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKK 155
Cdd:PRK05322 104 EAGYKIDHgFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTENEFIGVNSGIMDQFAIGMGKK 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 156 DHAIFLDTMTLEYEYVPLRLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKK----SFREVTKEDLERLS---- 227
Cdd:PRK05322 184 DHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKKldikSLGELTEEEFDEYSylik 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 228 -GTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGILGARMVGGGFGG 306
Cdd:PRK05322 264 dETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQEGVLGARMTGAGFGG 343

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 147736229 307 GVIVLSKKGAFGKIKEELVESYKKHFGIDLTFHEIESSDGVQKI 350
Cdd:PRK05322 344 CAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
PRK05101 PRK05101
galactokinase; Provisional
 3-347 9.33e-104

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 309.93  E-value: 9.33e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   3 VKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSDRFIFHSENV---NETVEM---EKIE--KLNKWTDYISGVIAS 74
Cdd:PRK05101  23 IQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAAdydNQQDEFsldAPIVphPEQQWANYVRGVVKH 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  75 FEKRGYRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGK 154
Cdd:PRK05101 103 LQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAENQFVGCNCGIMDQLISALGK 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 155 KDHAIFLDTMTLEYEYVPLrLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKSFREVTKEDLE----RLSGTL 230
Cdd:PRK05101 183 KDHALLIDCRSLETKAVPM-PEGVAVVIINSNVKRGLVDSEYNTRRQQCETAARFFGVKALRDVTLEQFNavaaELDPVV 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 231 RKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLR---GKEGilGARMVGggfggg 307
Cdd:PRK05101 262 AKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKaviGDQG--GVRMTG------ 333

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147736229 308 vivlskkGAFGK-----IKEELVES--------YKKHFGIDLTFHEIESSDGV 347
Cdd:PRK05101 334 -------GGFGGcivalVPEELVEAvrqavaeqYEAKTGLKETFYVCKASQGA 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 3-350 5.09e-92

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 280.17  E-value: 5.09e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229    3 VKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSDRFI--FHSENVNETVEMEKIE------KLNKWTDYISGVIAS 74
Cdd:TIGR00131  20 ARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNvrIYLANADNKFAERSLDlpldgsEVSDWANYFKGVLHV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   75 FEKRGYRVSP-VKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFG 153
Cdd:TIGR00131 100 AQERFNSFPLgADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAENHFVGVNCGIMDQAASVLG 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  154 KKDHAIFLDTMTLEYEYVPLRLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKS---FREVTKEDLER----- 225
Cdd:TIGR00131 180 KEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAATDkgaLRDFMNEYFARyiarl 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  226 --LSGTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGILGARMVGGG 303
Cdd:TIGR00131 260 tkMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAALVNGSGGSRMTGAG 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 147736229  304 FGGGVIVLSKKGAFGKIKEELVESYKKHFGIDLTFHEIESSDGVQKI 350
Cdd:TIGR00131 340 FGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGSC 386
PRK00555 PRK00555
galactokinase; Provisional
 5-324 2.59e-70

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 223.58  E-value: 2.59e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   5 APGRINIIGEHTDYNDGYVLPFAVNRYVFLSI--EGSDRFIFHSENVNETVEM---EKIEKLNKWTDYISGVIASFEKRG 79
Cdd:PRK00555   7 APGRINLIGEHTDYNLGFALPIALPQRTVVTFtpEHTDAITASSDRADGSARIpldTTPGQVTGWAAYAAGVIWALRGAG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  80 YRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHAI 159
Cdd:PRK00555  87 HPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAALFGAPKTAL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 160 FLDTMTLEYEYVPLRLE--GYEINLVDSNVKHELSSSEYNKRRQECEEVLKTLGKKSFREVTKEDLERLSGTLR----KR 233
Cdd:PRK00555 167 LIDFRDLTVRPVAFDPDaaGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRGLAALGAIADpidaRR 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 234 AQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDY-LRGkeGILGARMVGGGFGGGVIVLS 312
Cdd:PRK00555 247 ARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSaVRA--GALGARMTGGGFGGCVIALV 324

                        330
                 ....*....|..
gi 147736229 313 KKGAFGKIKEEL 324
Cdd:PRK00555 325 PADRAEDVADTV 336
PTZ00290 PTZ00290
galactokinase; Provisional
 5-346 1.27e-42

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 153.82  E-value: 1.27e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   5 APGRINIIGEHTDYNDGYVLPFAVNRYVFLSI-------EGSDRFIFHSEnvnETVEMEKI--EKLNK-WTDYISGVIA- 73
Cdd:PTZ00290  42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHILVgrvkhfcDHKLRFATETD---EHFVLDHLggAKHNKaWTTFVRGAATl 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  74 SFEKRGYRVSPVKIS-----VSSNLPMGAGLSSSAALEVATAYAISEYFSFN-----------------VPKLELVKIAR 131
Cdd:PTZ00290 119 RLNRLGVAIDAPSLQgvcmvVHGTLPMGAGMSASASFGVALLNAINTVVTRRykgcptspgrrysilppMSKEELIELAK 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 132 EA---EVEFVGVRCGIMDQFTSAFGKKDHAIFLDTMTLEYEYV---PLRLEGYEINLVDSNVKHEL---SSSEYNKRRQE 202
Cdd:PTZ00290 199 QArriETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHdmtPLLGDGACFLLIDSMIKHDLlggTAGMYNTVRSD 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 203 CEEVLKTLGKK-------SFREVTKE--------DLERLSGTLRK--------RAQHVLEENERVLK-------SVQALK 252
Cdd:PTZ00290 279 QEGAQKKIGKHryrgkpfTFSDLVRNpkkytfdgDVVAFMESCKPlmtpgefeRGTYNIMEQIRTLEfiklndpELPLSR 358

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 253 EGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGILGARMVGGGFGGGVIVLSKKGAFGKIKEELVESYKKHF 332
Cdd:PTZ00290 359 EERFRKAGEILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKARF 438

                        410
                 ....*....|....
gi 147736229 333 GIDLTFHEIESSDG 346
Cdd:PTZ00290 439 GVENDVYPVVAGDG 452
PLN02865 PLN02865
galactokinase
 3-298 1.49e-38

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 141.86  E-value: 1.49e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   3 VKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSI---------------EGSDRFIFHSENVNETVEMEKIEKLNKWTDY 67
Cdd:PLN02865  33 VVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFvpsgdpevllrsaqfEGEVRFRVDEIQHPIANVSSDSKEESNWGDY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  68 ISGVIASFEKRGYRVSPVKISVSSNLP--MGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGIM 145
Cdd:PLN02865 113 ARGAVYALQSRGHALSQGITGYISGSEglDSSGLSSSAAVGVAYLLALENANNLTVSPEDNIELDRLIENEYLGLRNGIL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 146 DQFTSAFGKKDHAIFLDTMTLEYEYVPLRLEG------YEINLVDSNVKHEL-SSSEYNKRRQECEEVLKTLGKKSFRE- 217
Cdd:PLN02865 193 DQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpFKILLAFSGLRHALtNKPGYNLRVSECQEAARFLLEASGNDe 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 218 -------VTKEDLER----LSGTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVD 286
Cdd:PLN02865 273 lepllcnVEPEVYEAhkckLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYE 352

                        330
                 ....*....|..
gi 147736229 287 YLRGKEGILGAR 298
Cdd:PLN02865 353 ILLKAPGVYGAR 364
PLN02521 PLN02521
galactokinase
 4-299 2.09e-31

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 123.66  E-value: 2.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   4 KAPGRINIIGEHTDYnDGY-VLPFAVNRYVFLSI---EGSDRFifHSENVNETVEM--------EKIEKLN-KWTDY-IS 69
Cdd:PLN02521  52 RSPGRVNLIGEHIDY-EGYsVLPMAIRQDTIVAIrraEGSKKL--RIANVNDKYTTctfpadpdQEVDLANhKWGNYfIC 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  70 GVIASFE---KRGYRVSP---VKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEvEFVGVRCG 143
Cdd:PLN02521 129 GYKGVFEflkSKGVDVGPpvgLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKCE-RHIGTQSG 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 144 IMDQFTSAFGKKDHAIFLDTMTLEYEYVPLRLEGYEI---NLVDSNvKHELSSSEYNKRRQEC---------------EE 205
Cdd:PLN02521 208 GMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVianSLAESN-KAVTAATNYNNRVVECrlaaivlavklgmsaEE 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 206 VL---KTLG----------------------KKSFRE--VTKEDLERLSGT-----------------------LRKRAQ 235
Cdd:PLN02521 287 AIskvKTLSdveglcvsfagshgssdpavavKELLHEgpYTAEEIEEILGEsltsifknsptslavlkaakhfkLHQRAV 366

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147736229 236 HVLEENERVLK----SVQALKEGD-FETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKeGILGARM 299
Cdd:PLN02521 367 HVYSEAKRVHAfrdtVSSSLSEEEkLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN-GALGARL 434
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 5-297 1.89e-29

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 114.17  E-value: 1.89e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   5 APGRINIIGEHTDYNDGYVLPFAVNRYVFLSIE--GSDRFIFHSENVNETVEMEkiEKLNKWTDYISGVIASFEKR-GYR 81
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEpsDDDKLRIESPDLGGTLDLD--PLADAALRYIKAAIEAALEYlGLP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  82 VSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGvRCGIMDQFTSAFGkkdHAIFL 161
Cdd:COG1577   79 LKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHG-NPSGLDTAASTYG---GPIYY 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 162 DTmTLEYEYVPLRLEGYeINLVDSNVKHElssseynkrrqeceevlktlgkksfrevTKE---DLERLSGTLRKRAQHVL 238
Cdd:COG1577  155 QR-GDRAEPLELPKNLP-LVVGDTGVPAS----------------------------TKElvaKVRKLKERNPELYEAFL 204

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 239 EENER-VLKSVQALKEGDFETLGKLLFSSHESLRDLYeVSCEETDFIVDYLRgKEGILGA 297
Cdd:COG1577  205 EEIGDlVEEAIEALEEGDLEALGELMNENHGLLRALG-VSTPELDRLVEAAR-KAGALGA 262
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 86-154 4.32e-20

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 82.60  E-value: 4.32e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147736229   86 KISVSSNLPMGAGLSSSAALEVATAYAISEYFsfnvpKLELVKIAREAEVEFVGVRCGIMDQFTSAFGK 154
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELF-----GLPLAKLALEAEELAGGGRGGGMDVAASLYGG 64
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 5-299 3.87e-18

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 83.11  E-value: 3.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229    5 APGRINIIGEHTD-YndGY-VLPFAVNRYVFLS-IEGSDRFIFHSENVNETVEMEKIEKLNKwtDYISGVIASFEKRGYR 81
Cdd:TIGR00549   1 APGKIILFGEHAVvY--GEpAIAAPIPLRTTVTvIESSDGSFIESDLGRGSLDDAPDELDGL--KYVLAEFLSRFSELNP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   82 VsPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGImDQFTSAFGK-----KD 156
Cdd:TIGR00549  77 P-PLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATSTSGGpvyfeKG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  157 HAIFLDTMTleyeyvplrLEGYEInLVDSNVKHelSSSE-YNKRRQECEEvlktlgkksFREVTKEDLERLSgtlrkraq 235
Cdd:TIGR00549 155 EGEFTKLIS---------LDGYFV-IADTGVSG--STKEaVARVRQLLER---------FPELIDSIMDAIG-------- 205

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 147736229  236 hvleenERVLKSVQALKEGDFETLGKLLFSSHESLRDLyEVSCEETDFIVDYLRgKEGILGARM 299
Cdd:TIGR00549 206 ------ELTLEAKAALQDGDVESLGELMNINQGLLKAL-GVSHPKLDQLVEIAR-KAGALGAKL 261
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 3-36 1.90e-14

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 66.71  E-value: 1.90e-14
                          10        20        30
                  ....*....|....*....|....*....|....
gi 147736229    3 VKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSI 36
Cdd:pfam10509  15 ASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAV 48
PRK03926 PRK03926
mevalonate kinase; Provisional
 5-299 5.22e-13

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 68.54  E-value: 5.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229   5 APGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSDRFIFHSENVNETVEMEKieklnkwtdYISGVIASF----EKRGy 80
Cdd:PRK03926   6 APGKIYLFGEHAVVYGKPAIACAIDLRTYVRAEFNDDSIYIESDYGKTGEKHP---------YVSAAIEKMreeaDKDG- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  81 rvspVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVEFVGVRCGImDQFTSAFGKkdhaiF 160
Cdd:PRK03926  76 ----VTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVSTMGG-----F 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229 161 LdtmtleyeYVPLR--LEGYEINLVDSNVKHELSSSEY----NKRRQECEEV----LKTLGKKSfrevtkedlerlsgtl 230
Cdd:PRK03926 146 V--------TIPDRkkLPFPECGIVVGYTGSSGSTKELvanvRKLKEEYPELiepiLSSIGKIS---------------- 201

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147736229 231 rKRAQHVLEENervlksvqalkegDFETLGKLLFSSHeSLRDLYEVSCEETDFIVDYLRGKeGILGARM 299
Cdd:PRK03926 202 -EKGEELILSG-------------DYVSLGELMNINQ-GLLDALGVSTKELSELIYAARTA-GALGAKI 254
COG1829 COG1829
Archaeal pantoate kinase [Coenzyme transport and metabolism]; Archaeal pantoate kinase is part ...
 82-136 1.01e-10

Archaeal pantoate kinase [Coenzyme transport and metabolism]; Archaeal pantoate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441434  Cd Length: 285  Bit Score: 61.83  E-value: 1.01e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 147736229  82 VSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAEVE 136
Cdd:COG1829   72 DRPVRVEHESPLPLGYGFGVSGAGALGTALALNRALGLGLSSNEAAQIAHEAEVE 126
PLN02677 PLN02677
mevalonate kinase
 84-154 1.40e-06

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 49.44  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  84 PVKISVSSNLPMGAGLSSSAALEVATAYAISEY-------------FSFNVPKLELV-KIAREAEVEFVGVRCGImDQFT 149
Cdd:PLN02677 129 PATVVVTSELPLGSGLGSSAAFCVALSAALLAAsdsisvstggngwSSLDETDLELVnKWAFEGEKIIHGKPSGI-DNTV 207


                 ....*
gi 147736229 150 SAFGK 154
Cdd:PLN02677 208 STYGN 212
PRK01212 PRK01212
homoserine kinase; Provisional
 23-134 1.43e-06

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 49.38  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147736229  23 VLPFAVNRYVFLSIEGSDRFIFHSENVNETVEMEKIEKLNKwTDYISGVIASFEKRGYRVSPVKISVSSNLPMGAGLSSS 102
Cdd:PRK01212  21 SLGLALSLYDEVLVGDVVSVEAEFSIEVIGEGADKLPLDPE-KNLVYQAALKFLEKLGKPPGLRIELEKNIPLGRGLGSS 99

                         90       100       110
                 ....*....|....*....|....*....|..
gi 147736229 103 AALEVATAYAISEYFSFNVPKLELVKIAREAE 134
Cdd:PRK01212 100 AASIVAGLVAANELAGLPLSKEELLQLATEGE 131
PLN02451 PLN02451
homoserine kinase
 72-134 6.75e-05

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 44.40  E-value: 6.75e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147736229  72 IASFEKRGYRVSPVKISVSSNLPMGAGLSSSAALEVATAYAISEYFSFNVPKLELVKIAREAE 134
Cdd:PLN02451 122 IATMKLLGIRSVGLSLSLHKGLPLGSGLGSSAASAAAAAVAVNELFGSPLGKDDLVLAGLESE 184
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 84-132 8.72e-03

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 37.41  E-value: 8.72e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 147736229  84 PVKISVSSNLPMGAGL---SSSAAlevATAYAISEYFSFNVPKLELVKIARE 132
Cdd:COG1947   83 GVDIHLEKRIPVGAGLgggSSDAA---ATLRALNRLWGLGLSREELAELAAK 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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