|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
2-599 |
0e+00 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 1231.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 2 SVPFNNPLPIPVLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWA 81
Cdd:PRK14491 1 STPFTNPLSIPLLGFCAYSGTGKTTLLEQLIPELNQRGLRLAVIKHAHHNFDVDQPGKDSYRLRKAGASQMLVASRVRWA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 82 LMTEDPVEDAPELPHLLAQIEADKVDIVLVEGFKKLALPKVELHRAAHGKPFIHPHDEHIQAIACcDDTELPSDLRRLDI 161
Cdd:PRK14491 81 LMTETPRDGEPELPHLLKQIDADKVDIVLVEGFKKLALPKIELHRAAHGKPWIYPHDENIIAIAC-DDTPLPSELPRLDI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 162 NDVGQIADFVIEYANNWRPSTPSLPLAPECGCELDTSKTLSVRQGIDKILSYVTPVSATEEVAIDDSTDRVLAQDAISPV 241
Cdd:PRK14491 160 NDVAAIADFVLEYAQNWQAPAQDLPLAPACCCDLLSPAFLSVSQGLDKILSLVTPVTETEDVALDELDGRVLAQDVISPV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 242 DVPQHTNSAMDGFAFAYSDPMLDSYTLVGDVMAGHSYQGTLNLGEAVRIMTGAPMPDGADTVQMKEMAEDSGDSVRFQGN 321
Cdd:PRK14491 240 NVPQHTNSAMDGYAFRSDDLEPESYTLVGEVLAGHQYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 322 IRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQGMLASLGFGKLPVYRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTI 401
Cdd:PRK14491 320 IKAGQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 402 KSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVISSGGVSVGDADFIKLALAKVGQINFWRINMRPGRPLAFGQI 481
Cdd:PRK14491 400 KAMAKKLGCEVIDLGIIEDSEAALEATLEQAAAQADVVISSGGVSVGDADYIKTALAKLGQIDFWRINMRPGRPLAFGQI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 482 GDSLFFGLPGNPVAVMVSFMQFVQPALRKLAGELEWAPTLVPAIADCTLRSRTGRTEFTRGVYHLGADGRLHVTSTGAQG 561
Cdd:PRK14491 480 GDSPFFGLPGNPVAVMVSFLQFVEPALRKLAGEQNWQPLLFPAIADETLRSRQGRTEFSRGIYHLGADGRLHVRTTGKQG 559
|
570 580 590
....*....|....*....|....*....|....*...
gi 126639910 562 SGMLSSMVKGNCLIVIAEKDEQLNVGDTVYIQPFADLL 599
Cdd:PRK14491 560 SGILSSMSEANCLIEIGPAAETVNAGETVTIQPLAGLL 597
|
|
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
201-598 |
0e+00 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 527.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 201 LSVRQGIDKILSYVTPVsATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFAFAYSD---PMLDSYTLVGDVMAGHS 277
Cdd:COG0303 2 ISVEEALALILAAVRPL-GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADlagANPVTLRVVGEIAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 278 YQGTLNLGEAVRIMTGAPMPDGADTVQMKEMAEDSGDSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQGMLA 357
Cdd:COG0303 81 PPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 358 SLGFGKLPVYRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQAD 437
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAEAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 438 VVISSGGVSVGDADFIKLALAKVG-QINFWRINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPALRKLAGELE 516
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 517 WAPTLVPAIADCTLRSRTGRTEFTRGVYHLGaDGRLHVTSTGAQGSGMLSSMVKGNCLIVIAEKDEQLNVGDTVYIQPFA 596
Cdd:COG0303 321 PPPPRVRARLAEDLPKKPGRTEFLRVRLERD-DGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVLLLD 399
|
..
gi 126639910 597 DL 598
Cdd:COG0303 400 GL 401
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
209-595 |
0e+00 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 520.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 209 KILSYVTPVSATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFAFAYSDPMLDSYTL--VGDVMAGHSYQGTLNLGE 286
Cdd:cd00887 6 ELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASVTLrvVGEIPAGEPPDGPLGPGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 287 AVRIMTGAPMPDGADTVQMKEMAEDSGDSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQGMLASLGFGKLPV 366
Cdd:cd00887 86 AVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIAEVPV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 367 YRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVISSGGVS 446
Cdd:cd00887 166 YRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVITSGGVS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 447 VGDADFIKLALAKV-GQINFWRINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPALRKLAGELEWAPTLVPAI 525
Cdd:cd00887 246 VGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPPRVKAR 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 526 ADCTLRSRTGRTEFTRGVYHLGaDGRLHVTSTGAQGSGMLSSMVKGNCLIVIAEKDEQLNVGDTVYIQPF 595
Cdd:cd00887 326 LAEDLKSKPGRREFLRVRLERD-EGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| MobB |
pfam03205 |
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop. |
13-146 |
6.55e-69 |
|
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
Pssm-ID: 427196 [Multi-domain] Cd Length: 133 Bit Score: 219.34 E-value: 6.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 13 VLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEDPVEDAP 92
Cdd:pfam03205 1 ILGIVGWSGSGKTTLLEKLIPELKARGLRVGTIKHAHHGFDIDKPGKDSWRHRKAGASEVLVASPGRWALMHELRDEPEP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 126639910 93 ELPHLLAQIEAdkVDIVLVEGFKKLALPKVELHRAAHGKPFIHPHDEHIQAIAC 146
Cdd:pfam03205 81 SLEELLARLSP--VDLVLVEGFKKEPYPKIEVHRAALGKPPLLPCDPDIIAVAS 132
|
|
| mobB |
TIGR00176 |
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ... |
13-173 |
1.28e-42 |
|
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]
Pssm-ID: 272943 [Multi-domain] Cd Length: 155 Bit Score: 150.22 E-value: 1.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 13 VLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEdpVEDAP 92
Cdd:TIGR00176 1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHDHHDFDIDKNGKDSYRHREAGADQVIVASSRRYAFMHE--TQEER 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 93 ELPHLLAQIEAdkVDIVLVEGFKKLALPKVELHRA-AHGKPFIHPhdeHIQAIAccDDTEL-PSDLRRLDINDVGQIADF 170
Cdd:TIGR00176 79 DLEALLDRLPD--LDIILVEGFKDSPLPKIVVFRNpAEESEIIRP---KIIAIA--SDESLsALKLPVLDLNDVEAIAAF 151
|
...
gi 126639910 171 VIE 173
Cdd:TIGR00176 152 IEK 154
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
373-500 |
9.96e-35 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 128.09 E-value: 9.96e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 373 AVFSTGDEVCQPGEplkpncIYDSNRFTIKSMVKQLGCEVIDLGIL--EDNESALVDALQGAAQQADVVISSGGVSVGDA 450
Cdd:smart00852 1 AIISTGDELLSGGQ------IRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126639910 451 DFIKLALAKVG--QINFWRINMRPGRPLAF---------GQIGDSLFFGLPGNPVAVMVSF 500
Cdd:smart00852 75 DLTPEALAELGgrELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMF 135
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
2-599 |
0e+00 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 1231.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 2 SVPFNNPLPIPVLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWA 81
Cdd:PRK14491 1 STPFTNPLSIPLLGFCAYSGTGKTTLLEQLIPELNQRGLRLAVIKHAHHNFDVDQPGKDSYRLRKAGASQMLVASRVRWA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 82 LMTEDPVEDAPELPHLLAQIEADKVDIVLVEGFKKLALPKVELHRAAHGKPFIHPHDEHIQAIACcDDTELPSDLRRLDI 161
Cdd:PRK14491 81 LMTETPRDGEPELPHLLKQIDADKVDIVLVEGFKKLALPKIELHRAAHGKPWIYPHDENIIAIAC-DDTPLPSELPRLDI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 162 NDVGQIADFVIEYANNWRPSTPSLPLAPECGCELDTSKTLSVRQGIDKILSYVTPVSATEEVAIDDSTDRVLAQDAISPV 241
Cdd:PRK14491 160 NDVAAIADFVLEYAQNWQAPAQDLPLAPACCCDLLSPAFLSVSQGLDKILSLVTPVTETEDVALDELDGRVLAQDVISPV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 242 DVPQHTNSAMDGFAFAYSDPMLDSYTLVGDVMAGHSYQGTLNLGEAVRIMTGAPMPDGADTVQMKEMAEDSGDSVRFQGN 321
Cdd:PRK14491 240 NVPQHTNSAMDGYAFRSDDLEPESYTLVGEVLAGHQYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 322 IRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQGMLASLGFGKLPVYRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTI 401
Cdd:PRK14491 320 IKAGQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 402 KSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVISSGGVSVGDADFIKLALAKVGQINFWRINMRPGRPLAFGQI 481
Cdd:PRK14491 400 KAMAKKLGCEVIDLGIIEDSEAALEATLEQAAAQADVVISSGGVSVGDADYIKTALAKLGQIDFWRINMRPGRPLAFGQI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 482 GDSLFFGLPGNPVAVMVSFMQFVQPALRKLAGELEWAPTLVPAIADCTLRSRTGRTEFTRGVYHLGADGRLHVTSTGAQG 561
Cdd:PRK14491 480 GDSPFFGLPGNPVAVMVSFLQFVEPALRKLAGEQNWQPLLFPAIADETLRSRQGRTEFSRGIYHLGADGRLHVRTTGKQG 559
|
570 580 590
....*....|....*....|....*....|....*...
gi 126639910 562 SGMLSSMVKGNCLIVIAEKDEQLNVGDTVYIQPFADLL 599
Cdd:PRK14491 560 SGILSSMSEANCLIEIGPAAETVNAGETVTIQPLAGLL 597
|
|
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
201-598 |
0e+00 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 527.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 201 LSVRQGIDKILSYVTPVsATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFAFAYSD---PMLDSYTLVGDVMAGHS 277
Cdd:COG0303 2 ISVEEALALILAAVRPL-GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADlagANPVTLRVVGEIAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 278 YQGTLNLGEAVRIMTGAPMPDGADTVQMKEMAEDSGDSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQGMLA 357
Cdd:COG0303 81 PPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 358 SLGFGKLPVYRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQAD 437
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAEAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 438 VVISSGGVSVGDADFIKLALAKVG-QINFWRINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPALRKLAGELE 516
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 517 WAPTLVPAIADCTLRSRTGRTEFTRGVYHLGaDGRLHVTSTGAQGSGMLSSMVKGNCLIVIAEKDEQLNVGDTVYIQPFA 596
Cdd:COG0303 321 PPPPRVRARLAEDLPKKPGRTEFLRVRLERD-DGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVLLLD 399
|
..
gi 126639910 597 DL 598
Cdd:COG0303 400 GL 401
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
209-595 |
0e+00 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 520.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 209 KILSYVTPVSATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFAFAYSDPMLDSYTL--VGDVMAGHSYQGTLNLGE 286
Cdd:cd00887 6 ELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASVTLrvVGEIPAGEPPDGPLGPGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 287 AVRIMTGAPMPDGADTVQMKEMAEDSGDSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQGMLASLGFGKLPV 366
Cdd:cd00887 86 AVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIAEVPV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 367 YRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVISSGGVS 446
Cdd:cd00887 166 YRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVITSGGVS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 447 VGDADFIKLALAKV-GQINFWRINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPALRKLAGELEWAPTLVPAI 525
Cdd:cd00887 246 VGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPPRVKAR 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 526 ADCTLRSRTGRTEFTRGVYHLGaDGRLHVTSTGAQGSGMLSSMVKGNCLIVIAEKDEQLNVGDTVYIQPF 595
Cdd:cd00887 326 LAEDLKSKPGRREFLRVRLERD-EGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
197-599 |
9.21e-146 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 427.59 E-value: 9.21e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 197 TSKTLSVRQGIDKILSYVTPVSATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFAFAYSDpmLDS---YTLVGDVM 273
Cdd:PRK10680 4 TAGLMSLETALTEMLSRVTPLTATETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLAD--LASgqpLPVAGKAF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 274 AGHSYQGTLNLGEAVRIMTGAPMPDGADTVQMKEMAEDSGDSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQ 353
Cdd:PRK10680 82 AGQPFHGEWPAGTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGTRLTTAEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 354 GMLASLGFGKLPVYRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAA 433
Cdd:PRK10680 162 PVLASLGIAEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALRAAFIEAD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 434 QQADVVISSGGVSVGDADFIKLALAKVGQINFWRINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPALRKLAG 513
Cdd:PRK10680 242 SQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAKLSG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 514 ELEWAPTL-VPAIADCTLRSRTGRTEFTRGVYHLGADGRLHVTSTGAQGSGMLSSMVKGNCLIVIAEKDEQLNVGDTVYI 592
Cdd:PRK10680 322 NTASGLPPrQRVRTASRLKKTPGRLDFQRGILQRNADGELEVTTTGHQGSHIFSSFSLGNCFIVLERERGNVEVGEWVEV 401
|
....*..
gi 126639910 593 QPFADLL 599
Cdd:PRK10680 402 EPFNALF 408
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
199-598 |
2.87e-100 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 317.93 E-value: 2.87e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 199 KTLSVRQGIDKILSYV-TPVSATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFA------FAYSD--PMldSYTLV 269
Cdd:PRK14498 8 TLVSLEEAREILESLLsELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAvraadtFGASEanPV--RLKLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 270 GDVMAGHSYQGTLNLGEAVRIMTGAPMPDGADTVQMKEMAE-DSGDSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRL 348
Cdd:PRK14498 86 GEVHAGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEeVDDDTVEIYRPVAPGENVRPAGEDIVAGELILPKGTRL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 349 KAAHQGMLASLGFGKLPVYRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDA 428
Cdd:PRK14498 166 TPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELEAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 429 LQGAAQQADVVISSGGVSVGDADFIKLALAKVGQINFWRINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPAL 508
Cdd:PRK14498 246 LRKALKECDLVLLSGGTSAGAGDVTYRVIEELGEVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPLL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 509 RKLAGELEWAPTLVPAIADCTLRSRTGRTEFTRGVyhLGADG-RLHVTSTGAqGSGMLSSMVKGNCLIVIAEKDEQLNVG 587
Cdd:PRK14498 326 RKLAGLPPPERATVKARLARRVRSELGREEFVPVS--LGRVGdGYVAYPLSR-GSGAITSLVRADGFIEIPANTEGLEAG 402
|
410
....*....|.
gi 126639910 588 DTVYIQPFADL 598
Cdd:PRK14498 403 EEVEVELFGPL 413
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
203-596 |
2.21e-85 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 272.56 E-value: 2.21e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 203 VRQGIDKILSYVTPVSATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFAFAYSDPM-LDSYTLV-GDVMAGHSYQG 280
Cdd:PRK14690 25 VDTALDLLRARLGPVTDIKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGFAGAAPEgAQVLPLIeGRAAAGVPFSG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 281 TLNLGEAVRIMTGAPMPDGADTVQMKEMAEDSGDSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQGMLASLG 360
Cdd:PRK14690 105 RVPEGMALRILTGAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLALLSAVG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 361 FGKLPVYRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVI 440
Cdd:PRK14690 185 LTRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLDRAAAEADVIL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 441 SSGGVSVGDADFIKLALAKVGQINFWRINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPALRKLAGELEWAPT 520
Cdd:PRK14690 265 TSGGASAGDEDHVSALLREAGAMQSWRIALKPGRPLALGLWQGVPVFGLPGNPVAALVCTLVFARPAMSLLAGEGWSEPQ 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126639910 521 LVPAIADCTLRSRTGRTEFTRGVYHLGadgrlHVTSTGAQGSGMLSSMVKGNCLIVIAEKDEQLNVGDTVYIQPFA 596
Cdd:PRK14690 345 GFTVPAAFEKRKKPGRREYLRARLRQG-----HAEVFRSEGSGRISGLSWAEGLVELGDGARRIAPGDPVRFIPYG 415
|
|
| MobB |
COG1763 |
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ... |
11-178 |
2.07e-76 |
|
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 441369 [Multi-domain] Cd Length: 162 Bit Score: 239.70 E-value: 2.07e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 11 IPVLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEDPVEd 90
Cdd:COG1763 1 MPVLGIVGYSGSGKTTLLEKLIPELKARGLRVGTIKHAHHDFDIDTPGKDSYRHREAGADEVLVASPERWALMTELPEE- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 91 aPELPHLLAQIEAdkVDIVLVEGFKKLALPKVELHRAAHGKPFIHPHDEHIQAIACcdDTELPSDLRRLDINDVGQIADF 170
Cdd:COG1763 80 -PSLDELLARLDD--VDLVLVEGFKHEPLPKIEVHRAEEGKPLLYPEDPNIIAVAS--DAPLPTGLPVFDLNDPEAIADF 154
|
....*...
gi 126639910 171 VIEYANNW 178
Cdd:COG1763 155 ILEWLKRK 162
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
201-575 |
1.92e-72 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 245.11 E-value: 1.92e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 201 LSVRQGIDKILSyVTPVSATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFAFAYSDPMLDsYTLVGDVMAGHSYQG 280
Cdd:PLN02699 8 ISVEEALSIVLS-VAARLSPVIVPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVASDGPGE-YPVITESRAGNDGLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 281 -TLNLGEAVRIMTGAPMPDGADTVQMKEMAEDSGD------SVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQ 353
Cdd:PLN02699 86 vTLTPGTVAYVTTGGPIPDGADAVVQVEDTEVVEDpldgskRVRILSQASKGQDIRPVGCDIEKDAKVLKAGERLGASEI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 354 GMLASLGFGKLPVYRRPKVAVFSTGDEVCQPGEP-LKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGA 432
Cdd:PLN02699 166 GLLATVGVTMVKVYPRPTVAILSTGDELVEPTTGtLGRGQIRDSNRAMLLAAAIQQQCKVVDLGIARDDEEELERILDEA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 433 -AQQADVVISSGGVSVGDADFIKLALAKVGQINFWRINMRPGRPLAFGQI---------GDSLFFGLPGNPVAVMVSFMQ 502
Cdd:PLN02699 246 iSSGVDILLTSGGVSMGDRDFVKPLLEKRGTVYFSKVLMKPGKPLTFAEIdaksapsnsKKMLAFGLPGNPVSCLVCFNL 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126639910 503 FVQPALRKLAGELEWAPTLVPAIADCTLRSRTGRTEFTRGVYHLGA-DGRLH----VTSTGAQGSGMLSSMVKGNCLI 575
Cdd:PLN02699 326 FVVPAIRYLAGWSNPHLLRVQARLREPIKLDPVRPEFHRAIIRWKLnDGSGNpgfvAESTGHQMSSRLLSMKSANALL 403
|
|
| PRK10751 |
PRK10751 |
molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional |
10-179 |
2.87e-71 |
|
molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional
Pssm-ID: 236750 [Multi-domain] Cd Length: 173 Bit Score: 226.88 E-value: 2.87e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 10 PIPVLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEDPVE 89
Cdd:PRK10751 5 MIPLLAIAAWSGTGKTTLLKKLIPALCARGIRPGLIKHTHHDMDVDKPGKDSYELRKAGAAQTLVASQQRWALMTETPDQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 90 DAPELPHLLAQIEADKVDIVLVEGFKKLALPKVELHRAAHGKPFIH-PHDEHIQAIACcdDTELPSDLRRLDINDVGQIA 168
Cdd:PRK10751 85 EELDLHYLASRMDASKLDLILVEGFKHEPIAKIALFRDGAGHRPEElVIDEHVIAVAS--DVPLNLDVPLLDINDVEQIA 162
|
170
....*....|.
gi 126639910 169 DFVIEYANNWR 179
Cdd:PRK10751 163 DFIVEWLQKQR 173
|
|
| MobB |
pfam03205 |
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop. |
13-146 |
6.55e-69 |
|
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
Pssm-ID: 427196 [Multi-domain] Cd Length: 133 Bit Score: 219.34 E-value: 6.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 13 VLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEDPVEDAP 92
Cdd:pfam03205 1 ILGIVGWSGSGKTTLLEKLIPELKARGLRVGTIKHAHHGFDIDKPGKDSWRHRKAGASEVLVASPGRWALMHELRDEPEP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 126639910 93 ELPHLLAQIEAdkVDIVLVEGFKKLALPKVELHRAAHGKPFIHPHDEHIQAIAC 146
Cdd:pfam03205 81 SLEELLARLSP--VDLVLVEGFKKEPYPKIEVHRAALGKPPLLPCDPDIIAVAS 132
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
195-513 |
5.72e-65 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 222.38 E-value: 5.72e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 195 LDTSKTLSVRQGIDKILSYVTPVSATEEVAIDDSTDRVLAQDAISPVDVPQHTNSAMDGFAFAySDPMLDSYTLVGDVMA 274
Cdd:PRK14497 5 VGDESLYSIDEAIKVFLSSLNFKPKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALK-SSCTPGEFKVIDKIGI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 275 GHSYQGTLNLGEAVRIMTGAPMPDGADTV-QMKEMAEDSGDSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQ 353
Cdd:PRK14497 84 GEFKEIHIKECEAVEVDTGSMIPMGADAViKVENTKVINGNFIKIDKKINFGQNIGWIGSDIPKGSIILRKGEVISHEKI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 354 GMLASLGFGKLPVYRRPKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAA 433
Cdd:PRK14497 164 GLLASLGISSVKVYEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIKRAI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 434 QQADVVISSGGVSVGDADFIKLALAKVGQINFWRINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPALRKLAG 513
Cdd:PRK14497 244 SVADVLILTGGTSAGEKDFVHQAIRELGNIIVHGLKIKPGKPTILGIVDGKPVIGLPGNIVSTMVVLNMVILEYLKSLYP 323
|
|
| MobB |
cd03116 |
molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace ... |
12-172 |
3.37e-63 |
|
molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In Escherichia coli, the synthesis of Moco involves genes from several loci: moa, mob, mod, moe and mog. The mob locus contains mobA and mobB genes. MobB catalyzes the attachment of the guanine dinucleotide to molybdopterin.
Pssm-ID: 349770 [Multi-domain] Cd Length: 157 Bit Score: 205.18 E-value: 3.37e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 12 PVLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEDPVEDa 91
Cdd:cd03116 1 KIVGVVGKSGSGKTTLIEKLIPELKARGLRVAVIKHTHHGFDIDTPGKDSYRHRQAGADAVLVSSPNRLALIHERPEWE- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 92 PELPHLLAQIEAdkVDIVLVEGFKKLALPKVELHRAAHGKPFIHPHDEHIQAIAcCDDTELPSDLRRLDINDVGQIADFV 171
Cdd:cd03116 80 LTLLELLARFSD--VDLVLVEGFKKEPIPKIEVFREEEGKPLLLPEDPNVIAVA-TDEPLDMLGLPVFDLNDVEEIADFI 156
|
.
gi 126639910 172 I 172
Cdd:cd03116 157 L 157
|
|
| PRK14489 |
PRK14489 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; ... |
8-177 |
2.00e-50 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional
Pssm-ID: 237727 [Multi-domain] Cd Length: 366 Bit Score: 178.41 E-value: 2.00e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 8 PLPIPVLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEDP 87
Cdd:PRK14489 202 TGAPPLLGVVGYSGTGKTTLLEKLIPELIARGYRIGLIKHSHHRVDIDKPGKDSHRLRAAGANPTMIVCPERWALMRETP 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 88 VEDAPeLPHLLAQIEADKVDIVLVEGFKKLALPKVELHRAAHGKPFihphDEHIQAIACCDDTELPSDLRRLDINDVGQI 167
Cdd:PRK14489 282 EEAVP-FKVLIATFDPEEVDLILVEGFKHEPLPKIQLHRQLISKPL----PELDLWTIATATDYPLARDPRLDINDVKQI 356
|
170
....*....|
gi 126639910 168 ADFVIEYANN 177
Cdd:PRK14489 357 ADFVRQWLLG 366
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
216-360 |
1.65e-44 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 155.03 E-value: 1.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 216 PVSATEEVAID--DSTDRVLAQDAISPVDVPQHTNSAMDGFAFAYSDpmLDSYTLVGDVMAGHSYQGTLNLGEAVRIMTG 293
Cdd:pfam03453 2 LLGTEETVPLEalDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAAD--GFGASEVNPIAAGEPPGPLLPGGEAVRIMTG 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126639910 294 APMPDGADTVQMKEMAEDSG-DSVRFQGNIRLGQHVRQAGEDIAKEQTALSAGHRLKAAHQGMLASLG 360
Cdd:pfam03453 80 APLPEGADAVVMVEDTEEGGgRTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| mobB |
TIGR00176 |
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ... |
13-173 |
1.28e-42 |
|
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]
Pssm-ID: 272943 [Multi-domain] Cd Length: 155 Bit Score: 150.22 E-value: 1.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 13 VLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEdpVEDAP 92
Cdd:TIGR00176 1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHDHHDFDIDKNGKDSYRHREAGADQVIVASSRRYAFMHE--TQEER 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 93 ELPHLLAQIEAdkVDIVLVEGFKKLALPKVELHRA-AHGKPFIHPhdeHIQAIAccDDTEL-PSDLRRLDINDVGQIADF 170
Cdd:TIGR00176 79 DLEALLDRLPD--LDIILVEGFKDSPLPKIVVFRNpAEESEIIRP---KIIAIA--SDESLsALKLPVLDLNDVEAIAAF 151
|
...
gi 126639910 171 VIE 173
Cdd:TIGR00176 152 IEK 154
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
370-506 |
1.12e-41 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 147.46 E-value: 1.12e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 370 PKVAVFSTGDEVCQPGEPLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVISSGGVSVGD 449
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126639910 450 ADFIKLALAKVGQINFW-----------RINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQP 506
Cdd:TIGR00177 81 RDVTPEALEELGEKEIPgfgefrmlsslPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
373-500 |
9.96e-35 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 128.09 E-value: 9.96e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 373 AVFSTGDEVCQPGEplkpncIYDSNRFTIKSMVKQLGCEVIDLGIL--EDNESALVDALQGAAQQADVVISSGGVSVGDA 450
Cdd:smart00852 1 AIISTGDELLSGGQ------IRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126639910 451 DFIKLALAKVG--QINFWRINMRPGRPLAF---------GQIGDSLFFGLPGNPVAVMVSF 500
Cdd:smart00852 75 DLTPEALAELGgrELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMF 135
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
371-508 |
1.66e-34 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 127.07 E-value: 1.66e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 371 KVAVFSTGDEvCQPGEplkpncIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVISSGGVSVGDA 450
Cdd:cd00758 1 RVAIVTVSDE-LSQGQ------IEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASREADLVLTTGGTGVGRR 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 451 DFIKLALAKVGQINFW--RINMRPGRPLAFGQIGDSLFFGLPGNPVAVMVSFMQFVQPAL 508
Cdd:cd00758 74 DVTPEALAELGEREAHgkGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
373-510 |
3.83e-34 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 126.59 E-value: 3.83e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 373 AVFSTGDEvcqpgepLKPNCIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVISSGGVSVGDADF 452
Cdd:pfam00994 1 AIITTGDE-------LLPGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDV 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 453 IKLALAKVGQ-------INFWRINMRPGRPLAFGQI-----GDSLFFGLPGNPVAVMVSFMQFVQPALRK 510
Cdd:pfam00994 74 TPEALAELGGrelpgfeELFRGVSLKPGKPVGTAPGailsrAGKTVFGLPGSPVAAKVMFELLLLPLLRH 143
|
|
| PRK14490 |
PRK14490 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; ... |
14-213 |
3.62e-24 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional
Pssm-ID: 237728 [Multi-domain] Cd Length: 369 Bit Score: 104.36 E-value: 3.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 14 LGFCAYSGTGKTTLLKKLIPELNRRgLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEDPVEdape 93
Cdd:PRK14490 8 IAFCGYSGSGKTTLITALVRRLSER-FSVGYYKHGCHRFDIDREGKDSDLARKAGASTVMISDPEKHALIAGGPPD---- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 94 lPHLLAQIEADkVDIVLVEGFKKLALPKVE--------LHRAAHGKPfihphdEHIQAIACCDDtelPSDLRRLDI---- 161
Cdd:PRK14490 83 -PLLERGAFLD-CDLLLVEGLKELPLPKILlvdrerkiLDLLEQGSV------TNVVALVVPDD---PASYPDFGLpvfh 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 126639910 162 -NDVGQIADFVIEYannWRPSTPSLPLApecGCELDTSKtlSVRQGIDK-ILSY 213
Cdd:PRK14490 152 rDDIAAIADFIEGH---LLGRAEEVPLS---GLVLAGGR--SSRMGSDKaLLSY 197
|
|
| PRK14495 |
PRK14495 |
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion ... |
13-172 |
2.54e-23 |
|
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional
Pssm-ID: 172967 Cd Length: 452 Bit Score: 103.22 E-value: 2.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 13 VLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWALMTEDPVEdAP 92
Cdd:PRK14495 3 VYGIIGWKDAGKTGLVERLVAAIAARGFSVSTVKHSHHDVDPDPPGSDSHRHRAAGAAEVVLAGPRRLILTREHRGE-PP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 93 ELPHLLAQIEAdkVDIVLVEGFKKLALPKVELHRAAHGKPFIHPHDEHIQAIAccDDTELPSDLRRLDINDVGQIADFVI 172
Cdd:PRK14495 82 RLAAILERMAP--VDLVLVEGYKTEPHPKIEVFRKAAGHALRQPEDPWVRAVA--SDTQMALPVPVLDLDDTEAVADFLL 157
|
|
| PRK14494 |
PRK14494 |
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing ... |
13-130 |
1.45e-19 |
|
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional
Pssm-ID: 237731 [Multi-domain] Cd Length: 229 Bit Score: 87.73 E-value: 1.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 13 VLGFCAYSGTGKTTLLKKLIPELNRRGLRLAVVKHAHHNFdvDIPGKDSYEMRKAGARQMLVASHVRWALMtedpvEDAP 92
Cdd:PRK14494 3 AIGVIGFKDSGKTTLIEKILKNLKERGYRVATAKHTHHEF--DKPDTDTYRFKKAGAEVVVVSTDETAAFL-----YDRM 75
|
90 100 110
....*....|....*....|....*....|....*....
gi 126639910 93 ELPHLLAQIEAdkvDIVLVEGFKKLA-LPKVELHRAAHG 130
Cdd:PRK14494 76 DLNEILSLLDA---DFLLIEGFKELLnIPKILCLRDAEG 111
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
523-595 |
1.23e-15 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 71.87 E-value: 1.23e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126639910 523 PAIADCTLRSRTGRTEFTRGVYHLgADGRLHVTSTGAQGSGMLSSMVKGNCLIVIAEKDEQLNVGDTVYIQPF 595
Cdd:pfam03454 1 KARLARDLKSDPGRREFVRVRLHE-EDGRYYAEPIGKQGSGMLSSLAEANGLIVVPEGTEGLEAGEEVEVILL 72
|
|
| PRK14493 |
PRK14493 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ... |
13-170 |
1.83e-11 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional
Pssm-ID: 237730 [Multi-domain] Cd Length: 274 Bit Score: 65.02 E-value: 1.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 13 VLGFCAYSGTGKTTLLKKLIPELNRRGlRLAVVKHAHHNFDVDiPGKDSYEMRKAGARQMLVASHVRWALMTEDP-VEDA 91
Cdd:PRK14493 3 VLSIVGYKATGKTTLVERLVDRLSGRG-RVGTVKHMDTERLNP-DGTDTGRHFDAGADVVYGLTDGEWVASGRDRsLDDA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 92 pelphlLAQIEADkVDIVLVEGFKKLALPKVEL-------HRAAHGKPFIHPHDEHIQAIAC-CDDTE-LPSDLRRL--- 159
Cdd:PRK14493 81 ------LDDLAPG-MDYAVVEGFKDSRLPKVVLgdmdadsDVVARAPTAADLDTEDLVAALEsQPPYVtLESLVAKVkrs 153
|
170
....*....|..
gi 126639910 160 -DINDVGQIADF 170
Cdd:PRK14493 154 pDADKAGAIATF 165
|
|
| MoeA_like |
cd03522 |
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ... |
367-491 |
1.77e-07 |
|
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.
Pssm-ID: 239599 Cd Length: 312 Bit Score: 53.32 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126639910 367 YRRPKVAVFSTGDEVCQPGeplkpncIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQ-ADVVISSGGV 445
Cdd:cd03522 157 FRPLRVGLIVTGSEVYGGR-------IEDKFGPVLRARLAALGVELVEQVIVPHDEAAIAAAIAEALEAgAELLILTGGA 229
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 126639910 446 SVGDADFIKLALAKVG-QINfwRINM--RPGRPLAFGQIGDSLFFGLPG 491
Cdd:cd03522 230 SVDPDDVTPAAIRAAGgEVI--RYGMpvDPGNLLLLGYLGGVPVIGLPG 276
|
|
| cobW |
pfam02492 |
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ... |
12-45 |
5.55e-04 |
|
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.
Pssm-ID: 396860 Cd Length: 179 Bit Score: 41.08 E-value: 5.55e-04
10 20 30
....*....|....*....|....*....|....
gi 126639910 12 PVLGFCAYSGTGKTTLLKKLIPElNRRGLRLAVV 45
Cdd:pfam02492 1 PVTVITGFLGSGKTTLLNHLLKQ-NRAGLRIAVI 33
|
|
| cinA |
cd00885 |
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon ... |
371-444 |
5.78e-04 |
|
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, where the domain is presumed to bind molybdopterin.
Pssm-ID: 238450 [Multi-domain] Cd Length: 170 Bit Score: 40.93 E-value: 5.78e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126639910 371 KVAVFSTGDEVcqpgepLKPNcIYDSNRFTIKSMVKQLGCEVIDLGILEDNESALVDALQGAAQQADVVISSGG 444
Cdd:cd00885 1 TAEIIAIGDEL------LSGQ-IVDTNAAFLAKELAELGIEVYRVTVVGDDEDRIAEALRRASERADLVITTGG 67
|
|
| |
