NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|118173722|gb|ABK74618|]
View 

putative transcriptional regulatory protein [Mycolicibacterium smegmatis MC2 155]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-139 4.27e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.18  E-value: 4.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118173722  14 ELQRVLSKVFSVLRRGDTHRGTAGDLTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSD 93
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 118173722  94 LRAVLVDVTPQGLVQHRESLAARRADLAERLSKLSDEDLATLARAL 139
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLL 136
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-139 4.27e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.18  E-value: 4.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118173722  14 ELQRVLSKVFSVLRRGDTHRGTAGDLTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSD 93
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 118173722  94 LRAVLVDVTPQGLVQHRESLAARRADLAERLSKLSDEDLATLARAL 139
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLL 136
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
38-132 1.41e-19

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 78.40  E-value: 1.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118173722    38 DLTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAVLVDVTPQGLVQHRESLAARR 117
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....*
gi 118173722   118 ADLAERLSKLSDEDL 132
Cdd:smart00347  87 ETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 39-97 6.02e-14

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 62.56  E-value: 6.02e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 118173722   39 LTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAV 97
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
38-139 4.66e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 38.34  E-value: 4.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118173722  38 DLTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAVLVDVTPQGLVQHRESLAARR 117
Cdd:PRK11512  37 DITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLVG 116

                         90       100
                 ....*....|....*....|...
gi 118173722 118 ADLAERLSK-LSDEDLATLARAL 139
Cdd:PRK11512 117 QDLHQELTKnLTADEVATLEHLL 139
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-139 4.27e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.18  E-value: 4.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118173722  14 ELQRVLSKVFSVLRRGDTHRGTAGDLTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSD 93
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 118173722  94 LRAVLVDVTPQGLVQHRESLAARRADLAERLSKLSDEDLATLARAL 139
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLL 136
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
38-132 1.41e-19

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 78.40  E-value: 1.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118173722    38 DLTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAVLVDVTPQGLVQHRESLAARR 117
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....*
gi 118173722   118 ADLAERLSKLSDEDL 132
Cdd:smart00347  87 ETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 39-97 6.02e-14

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 62.56  E-value: 6.02e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 118173722   39 LTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAV 97
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-96 7.86e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 49.51  E-value: 7.86e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 118173722   38 DLTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRA 96
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
46-90 3.55e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 38.65  E-value: 3.55e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 118173722  46 ILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRD 90
Cdd:COG1321   15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPY 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
38-139 4.66e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 38.34  E-value: 4.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118173722  38 DLTLAQLSILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAVLVDVTPQGLVQHRESLAARR 117
Cdd:PRK11512  37 DITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLVG 116

                         90       100
                 ....*....|....*....|...
gi 118173722 118 ADLAERLSK-LSDEDLATLARAL 139
Cdd:PRK11512 117 QDLHQELTKnLTADEVATLEHLL 139
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
21-90 1.37e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.17  E-value: 1.37e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118173722  21 KVFSVLRRgDTHRGtagdltlaqlsILLTLLEGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRD 90
Cdd:COG3398   89 KILAYLRR-ETPRR-----------ILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERD 146
HTH_27 pfam13463
Winged helix DNA-binding domain;
52-105 5.34e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 33.80  E-value: 5.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 118173722   52 EGGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAVLVDVTPQG 105
Cdd:pfam13463  15 RGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH