|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
19-953 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1323.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 19 RYNAdlaGQIERAWQETWSDRGTFNVANpvgslaptdgsDVPADKMFVQDMFPYPSGDgLHVGHPLGYIATDVYARYYRM 98
Cdd:COG0495 4 RYNP---KEIEKKWQKYWEENGTFKADE-----------DSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRM 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 99 LGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYNAwf 178
Cdd:COG0495 69 QGYNVLHPMGWDAFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEK-- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 179 drdqnkarriselveefesgkrtlddgrnwadlskgeradvidgyRLVYRADSMVNWCPGLGTVLANEEVTsEGRSDRGN 258
Cdd:COG0495 147 ---------------------------------------------GLAYRKEAPVNWCPVDQTVLANEQVI-DGRCWRCG 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 259 FPVFRKRLRQWMMRITAYSDRLLEDLDVLD-WPEKVKTMQRNWIGRSTGASVLFATAA--DDIEVFTTRPDTLFGATYLV 335
Cdd:COG0495 181 APVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGsdEKITVFTTRPDTLFGATFMV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 336 LAPEHDLVDTLVTDAwpdgtderwtygaatPREAVAAYRTDIAAKSDLERQ-ENKTKTGVFLGAYATNPADGKQVPIFIA 414
Cdd:COG0495 261 LAPEHPLVKELATPE---------------QNAAVAAFIEEAKKKSEIERTsETKEKTGVFTGLYAINPLTGEKIPIWIA 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 415 DYVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTGGD-----ISEAAYAGDGTMVNSGFLDGMDVASAKEAIIARL 489
Cdd:COG0495 326 DYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDgddpdILEEAYTGDGVLINSGEFDGLDSEEAKEAIIEWL 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 490 EADGRGKRRVEYKLRDWLFARQRYWGEPFPIVYDADGRAHPLPESALPVELPDVPDYSPvlfdpddadsEPSPPLNKATE 569
Cdd:COG0495 406 EEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDP----------TGGSPLARAPE 475
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 570 WVHVELDLGDGlqSYTRDTNVMPQWAGSSWYELRYTDPHNPDEMCAKENEAYWMgprpdehgpedPggVDLYVGGVEHAV 649
Cdd:COG0495 476 WVNVTCPKCGG--PARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWL-----------P--VDQYIGGIEHAI 540
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 650 LHLLYSRFWHKVLYDLGYVSSREPYRRLVNQGYIQAfaytdsrgtyvpaaevIERDGkffwpgpdgeiEVNQEFGKIGKS 729
Cdd:COG0495 541 LHLLYARFFTKVLRDLGLVSFDEPFKRLLTQGMVLE----------------VGKDG-----------VVIGGIEKMSKS 593
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 730 LKNSVSPDEICDNYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRVVIDETSG-NVRVVEHEALSDETLRLLH 808
Cdd:COG0495 594 KGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEAlKLDVADLSEADKELRRALH 673
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 809 RTIEGVREDYAALRNNTAAAKLIEYTNHLTK-------EGVAARAAIEPLVLMVAPLAPHLAEELWKRLGHDTSLAHGPF 881
Cdd:COG0495 674 KTIKKVTEDIERLRFNTAIAALMELVNALYKakdsgeaDRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVADAPW 753
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 118170488 882 PEADPQYLVEDTIEFPVQVNGKVRGKIVVAADADKAALEAAALADEKVQAFLAGATPKKVIVVPGRLVNLVV 953
Cdd:COG0495 754 PEADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVV 825
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
27-953 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 1062.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 27 QIERAWQETWSDRGTFNVAnpvgslaptDGSDVPADKMFVQDMFPYPSGDGLHVGHPLGYIATDVYARYYRMLGRNVLHA 106
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTP---------DDVDTSKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 107 LGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYNawfdrdqnkar 186
Cdd:PLN02563 155 MGWDAFGLPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLK----------- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 187 riselveefesgkrtlddgrnwadlsKGeradvidgyrLVYRADSMVNWCPGLGTVLANEEVTsEGRSDRGNFPVFRKRL 266
Cdd:PLN02563 224 --------------------------RG----------LAYQAEVPVNWCPALGTVLANEEVV-DGLSERGGHPVIRKPM 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 267 RQWMMRITAYSDRLLEDLDVLDWPEKVKTMQRNWIGRSTGASVLFATAADD-------IEVFTTRPDTLFGATYLVLAPE 339
Cdd:PLN02563 267 RQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVLDGEgkerdekITVYTTRPDTLFGATYLVVAPE 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 340 HDLVDTLVTDawpdgtderwtygaaTPREAVAAYRTDIAAKSDLERQE-NKTKTGVFLGAYATNPADGKQVPIFIADYVL 418
Cdd:PLN02563 347 HPLLSSLTTA---------------EQKEAVEEYVDAASRKSDLERTElQKEKTGVFTGSYAINPATGEAIPIWVADYVL 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 419 AGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTGGDI----SEAAYAGDGTMVNSGF----LDGMDVASAKEAIIARLE 490
Cdd:PLN02563 412 GSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGneddAEKAYTGEGVIVNSSSsgldINGLSSKEAAKKVIEWLE 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 491 ADGRGKRRVEYKLRDWLFARQRYWGEPFPIVY-DADGRAHPLPESALPVELPDVPDYSPvlfdpddaDSEPSPPLNKATE 569
Cdd:PLN02563 492 ETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFlEDSGEPVPVPESDLPLTLPELDDFTP--------TGTGEPPLAKAVS 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 570 WVHVeLDLGDGlQSYTRDTNVMPQWAGSSWYELRYTDPHNPDEMCAKENEAYWMgprpdehgpedPggVDLYVGGVEHAV 649
Cdd:PLN02563 564 WVNT-VDPSSG-KPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWM-----------P--VDLYVGGAEHAV 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 650 LHLLYSRFWHKVLYDLGYVSSREPYRRLVNQGYI----QAFAYTDSRGTYV----------------PAAEVIERdGKFF 709
Cdd:PLN02563 629 LHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMIlgevEYTAFKDSDGEYVsadtadrlgelqqekiPEEKVIKS-GDSF 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 710 WPGPDGEIEVNQEFGKIGKSLKNSVSPDEICDNYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRVVI----- 784
Cdd:PLN02563 708 VLKDDPSIRLIARAHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVgaplp 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 785 DETSGNVRVVEHEALSDETLRLLHRTIEGVREDYAALRNNTAAAKLIEYTNHLTKEGVAARAAIEPLVLMVAPLAPHLAE 864
Cdd:PLN02563 788 DGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKWDKVPREAIEPFVLLLSPYAPHLAE 867
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 865 ELWKRLGHDTSLAHGPFPEADPQYLVEDTIEFPVQVNGKVRGKIVVAADADKAALEAAALADEKVQAFLAGATPKKVIVV 944
Cdd:PLN02563 868 ELWFRLGHSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKRIYV 947
|
....*....
gi 118170488 945 PGRLVNLVV 953
Cdd:PLN02563 948 PGKILNVIL 956
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
20-953 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 973.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 20 YNADLagqIERAWQETWSDRGTFnvanpvgslAPTDGSDVPadKMFVQDMFPYPSGDgLHVGHPLGYIATDVYARYYRML 99
Cdd:TIGR00396 1 YNHIE---IEEKWQQKWDENKTF---------KVTDDSSKP--KYYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMK 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 100 GRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYnawfd 179
Cdd:TIGR00396 66 GYNVLHPIGWDAFGLPAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELF----- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 180 rdqnkarriselveefESGkrtlddgrnwadlskgeradvidgyrLVYRADSMVNWCPGLGTVLANEEVTSEGRSDRGNF 259
Cdd:TIGR00396 141 ----------------EKG--------------------------LAYVKEADVNWCPNDGTVLANEQVDSDGRSWRGDT 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 260 PVFRKRLRQWMMRITAYSDRLLEDLDVLD-WPEKVKTMQRNWIGRSTGASVLFATA--ADDIEVFTTRPDTLFGATYLVL 336
Cdd:TIGR00396 179 PVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIAdhDEKITVFTTRPDTIFGVTYLAL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 337 APEHDLVDtLVTDAWPDgtderwtygaatpreaVAAYRTDIAAKSDLERQ-ENKTKTGVFLGAYATNPADGKQVPIFIAD 415
Cdd:TIGR00396 259 APEHPLVE-KAAENNPK----------------VAAFIKKILNKTVAERTkATKEKKGVDTGIKAIHPLTGEKIPIWVAN 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 416 YVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTGGD---ISEAAYAGDGTMVNSGFLDGMDVASAKEAIIARLEAD 492
Cdd:TIGR00396 322 YVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEkdlSLTAAYTEDGVLVNSGEFNGLNSSEARNAIIDMLEKE 401
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 493 GRGKRRVEYKLRDWLFARQRYWGEPFPIVYDADGRAHPLPESALPVELPDVPDYSPvlfdpddadsEPSPPLNKATEWVH 572
Cdd:TIGR00396 402 GKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDG----------DGGSPLSRIPEWVN 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 573 VElDLGDGLQSyTRDTNVMPQWAGSSWYELRYTDPHNPDEMCAKENEAYWMgPrpdehgpedpggVDLYVGGVEHAVLHL 652
Cdd:TIGR00396 472 VT-CPSCGKPA-LRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWL-P------------VDLYIGGIEHAILHL 536
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 653 LYSRFWHKVLYDLGYVSSREPYRRLVNQGYIQAFAYTDSRGtyVPAAEVIERDGKFFwpGPDGEIEVNQEFGKIGKSLKN 732
Cdd:TIGR00396 537 LYARFFHKFLRDIGYVNTKEPFKKLINQGMVLGFYYPPNGK--VPADVLTERDEKGK--DKAGGELVYVGYEKMSKSKGN 612
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 733 SVSPDEICDNYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRVVIDETS-GNVRVVEHEALSD---ETLRLLH 808
Cdd:TIGR00396 613 GIDPQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGeLDAASLTVTALEEaqkELRRDVH 692
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 809 RTIEGVREDYAALRN-NTAAAKLIEYTNHLTK--EGVAARAAIEPLVLMVAPLAPHLAEELWKRLGHDTSLAH-GPFPEA 884
Cdd:TIGR00396 693 KFLKKVTEDLEKRESfNTAISAMMELLNKLYKakKEALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFIIDnAKWPVV 772
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 118170488 885 DPQYLVEDTIEFPVQVNGKVRGKIVVAADADKAALEAAALADEKVQAFLAGATPKKVIVVPGRLVNLVV 953
Cdd:TIGR00396 773 DETALVEDKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVI 841
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
298-490 |
1.84e-79 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 255.93 E-value: 1.84e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 298 RNWIGRSTGASVLFATAADD--IEVFTTRPDTLFGATYLVLAPEHDLVDTLvtdawpdgtderwtygaATPREAVAAYRT 375
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDekIEVFTTRPDTLMGVTFVALAPEHPLVEKL-----------------AEKNPEVAAFIE 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 376 DIAAKSDLERQ-ENKTKTGVFLGAYATNPADGKQVPIFIADYVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTGG 454
Cdd:pfam13603 64 ECKNTSEIERTsETKEKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPE 143
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 118170488 455 D------ISEAAYAGDGTMVNSGFLDGMDVASAKEAIIARLE 490
Cdd:pfam13603 144 DgdldldIMTEAYTEEGILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
63-764 |
2.44e-71 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 238.69 E-value: 2.44e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 63 KMFVQDMFPYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQL 142
Cdd:cd00812 1 KFYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 143 GRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYnawfdrdqnkarriselveefesgkrtlddgrnwadlSKGeradvidg 222
Cdd:cd00812 80 KRMGFSYDWRREFTTCDPEYYKFTQWLFLKLY-------------------------------------EKG-------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 223 yrLVYRADSMVNWCpglgtvlaneevtsegrsdrgnfpvfrKRLRQWMMRitaYSDRlledldvlDWPEKVKTMQRNWig 302
Cdd:cd00812 115 --LAYKKEAPVNWC---------------------------KLLDQWFLK---YSET--------EWKEKLLKDLEKL-- 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 303 rstgasvlfataaddievfttrpdtlfgatylvlapehdlvdtlvtDAWPDgtderwtygaatpreavaayrtdiaaksd 382
Cdd:cd00812 153 ----------------------------------------------DGWPE----------------------------- 157
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 383 lerqenKTKTgvflgayatnpadgkqvpifiadyvlagygtgaimavpggDQRDWdfakefglpiIEvvtggdiseaaya 462
Cdd:cd00812 158 ------EVRA----------------------------------------MQENW----------IG------------- 168
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 463 gdgtmvnsgfldgmdvasakeaiiarleadgrgkrrveyklrdwlFARQRYWGEPFPIvydadgrahplpesalpvelpd 542
Cdd:cd00812 169 ---------------------------------------------CSRQRYWGTPIPW---------------------- 181
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 543 vpdyspvlfdpddadsepspplnkatewvhveldlgdglqsytrdTNVMPQWAGSSWYELRYTDPHNPDEMCAKENEA-- 620
Cdd:cd00812 182 ---------------------------------------------TDTMESLSDSTWYYARYTDAHNLEQPYEGDLEFdr 216
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 621 ----YWMgprpdehgpedPggVDLYVGGVEHAVLHLLYSRFWHKVLYDLGYVSSrEPYRRLVNQGYIQAfaytdsrgtyv 696
Cdd:cd00812 217 eefeYWY-----------P--VDIYIGGKEHAPNHLLYSRFNHKALFDEGLVTD-EPPKGLIVQGMVLL----------- 271
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118170488 697 paaevierdgkffwpgpDGEievnqefgKIGKSLKNSVSPDEICDNYGADTLRVYEMSMGPLEASRPW 764
Cdd:cd00812 272 -----------------EGE--------KMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
28-891 |
4.21e-49 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 187.96 E-value: 4.21e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 28 IERAWQETWSDRGTFnvanpvgsLAPTDGSDVPadkmFVQDMFP-YPSGdGLHVGHPLGYIATDVYARYYRMLGRNVLHA 106
Cdd:TIGR00422 10 VEKKWYKKWEKSGFF--------KPDGNSNKPP----FCIDIPPpNVTG-SLHIGHALNWSIQDIIARYKRMKGYNVLWL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 107 LGFDAFGLPAE-----QYAVQTGTH---PRTR--------TEANIVNFRRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIF 170
Cdd:TIGR00422 77 PGTDHAGIATQvkvekKLGAEGKTKhdlGREEfrekiwewKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 171 LQIYNawfdrdqnkarriselveefesgkrtlddgrnwadlsKGeradvidgyrLVYRADSMVNWCPGLGTVLANEEVts 250
Cdd:TIGR00422 157 VRLYE-------------------------------------KG----------LIYRGEYLVNWDPKLNTAISDIEV-- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 251 EGRSDRGNFPVFRKRLrqwmmritaysdrllEDldvldwpekvktmqrnwigrstgasvlfaTAADDIEVFTTRPDTLFG 330
Cdd:TIGR00422 188 EYKEVKGKLYYIRYPL---------------AN-----------------------------GSKDYLVVATTRPETMFG 223
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 331 ATYLVLAPEhdlvdtlvtdawpdgtDERWTYgaatpreavaayrtdiaaksdlerqenktktgvFLGAYATNPADGKQVP 410
Cdd:TIGR00422 224 DTAVAVHPE----------------DERYKH---------------------------------LIGKKVILPLTGRKIP 254
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 411 IFIADYVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVT-GGDISEAAyagdgtmvnsGFLDGMDVASAKEAIIARL 489
Cdd:TIGR00422 255 IIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDeDGLLNENA----------GKYQGLTRFEARKKIVEDL 324
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 490 EADG----------------RGKRRVE-------------------------------------Y-----KLRDWLFARQ 511
Cdd:TIGR00422 325 KEEGllvkiephthnvgtcwRSGTVVEpllskqwfvkvekladkaleaaeegeikfvpkrmekrYlnwlrNIKDWCISRQ 404
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 512 RYWGEPFPIVY-DADGRAHplpesalpvelpdvpdyspvlfdpdDADSEPSPPLNKATewvhveldlgDGLQSYTRDTNV 590
Cdd:TIGR00422 405 LIWGHRIPVWYcKECGEVY-------------------------VAKEEPLPDDKTNT----------GPSVELEQDTDV 449
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 591 MPQWAGSSWYELRYTDPHNPDEMCAKENEaywmgprpdehgpedpggVDLYVGGveHAVLhllysRFWhkVLYDLgyvss 670
Cdd:TIGR00422 450 LDTWFSSSLWPFSTLGWPDETKDLKKFYP------------------TDLLVTG--YDII-----FFW--VARMI----- 497
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 671 repyrrlvnqgyIQAFAYTDSrgtyVPAAEV----IERDgkffwpgPDGEievnqefgKIGKSLKNSVSPDEICDNYGAD 746
Cdd:TIGR00422 498 ------------FRSLALTGQ----VPFKEVyihgLVRD-------EQGR--------KMSKSLGNVIDPLDVIEKYGAD 546
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 747 TLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRVV------IDETSGNVRVVEHEALSDE-TLRLLHRTIEGVREDYA 819
Cdd:TIGR00422 547 ALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASrfvlmnLSDDLELSGGEEKLSLADRwILSKLNRTIKEVRKALD 626
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 820 ALRNNTAAAKLIEYTNH--------LTK------EGVAARAAI-------EPLVLMVAPLAPHLAEELWKRLGHDT-SLA 877
Cdd:TIGR00422 627 KYRFAEAAKALYEFIWNdfcdwyieLVKyrlyngNEAEKKAARdtlyyvlDKALRLLHPFMPFITEEIWQHFKEGAdSIM 706
|
970
....*....|....
gi 118170488 878 HGPFPEADPQYLVE 891
Cdd:TIGR00422 707 LQSYPVVDAEFVDE 720
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
28-906 |
2.90e-41 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 163.44 E-value: 2.90e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 28 IERAWQETWSDRGTF----NVANPVGSLaptdgsDVPAdkmfvqdmfPYPSGDgLHVGHPLGYIATDVYARYYRMLGRNV 103
Cdd:PRK13208 15 LEEKWQKIWEEEGTYkfdpDERKPVYSI------DTPP---------PTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 104 LHALGFDAFGLPAE-----QYAVQTGTHPRTR--------TEANIVNFRRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIF 170
Cdd:PRK13208 79 FFPQGWDDNGLPTErkvekYYGIRKDDISREEfielcrelTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 171 LQIYNawfdrdqnkarriselveefesgkrtlddgrnwadlsKGEradvidgyrlVYRADSMVNWCPGLGTVLANEEVts 250
Cdd:PRK13208 159 LDLYK-------------------------------------KGL----------IYRAEAPVLWCPRCETAIAQAEV-- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 251 egrSDRgnfpvfrkrlrqwmMRITAYsdrlledldvldwpekvktmqrNWIGrstgasvlFATAA-DDIEVFTTRPDtLF 329
Cdd:PRK13208 190 ---EYR--------------EREGKL----------------------NYIK--------FPVEDgEEIEIATTRPE-LL 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 330 GATYLVLApeHdlvdtlvtdawPDgtDERwtygaatpreavaaYRtdiaaksDLerqenktktgvfLGAYATNPADGKQV 409
Cdd:PRK13208 222 PACVAVVV--H-----------PD--DER--------------YK-------HL------------VGKTAIVPLFGVEV 253
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 410 PIfIAD-YVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVvtggdISEaayagDGTMV-NSGFLDGMDVASAKEAIIA 487
Cdd:PRK13208 254 PI-LADpLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRII-----IDE-----DGRMTeAAGKLAGLTIEEARKKIVE 322
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 488 RLEADG----------------RGKRRVE-------------------------------YKLR----------DWLFAR 510
Cdd:PRK13208 323 DLKSGGllgkqepikhnvkfceRCDTPLEilvtrqwfikvldlkeellergkeinwypehMRVRlenwieglnwDWCISR 402
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 511 QRYWGEPFPIVYDAD-GRAHPLPESALPVelpdvpdyspvlfDPddadSEPSPPLNKATEWVHVELdlgdglqsyTRDTN 589
Cdd:PRK13208 403 QRYFGTPIPVWYCKDcGHPILPDEEDLPV-------------DP----TKDEPPGYKCPQCGSPGF---------EGETD 456
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 590 VMPQWAGSS---WYELRYTDPHNpdemcakeneaywmgpRPDEHGPED--PGGVD-----LYvggveHAVL--HLLY-SR 656
Cdd:PRK13208 457 VMDTWATSSitpLIVTGWERDED----------------LFEKVFPMDlrPQGHDiirtwLF-----YTILraYLLTgKL 515
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 657 FWHKVlydlgyvssrepyrrLVNqGYIQafaytdsrgtyvpaaevierdgkffwpGPDGEievnqefgKIGKSLKNSVSP 736
Cdd:PRK13208 516 PWKNI---------------MIS-GMVL---------------------------DPDGK--------KMSKSKGNVVTP 544
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 737 DEICDNYGADTLRvYEMSMGPLEASRPWATKDVVGAHRFLQRVW---RVV--IDETSGNVRVVEHEALSDETLRLLHRTI 811
Cdd:PRK13208 545 EELLEKYGADAVR-YWAASARLGSDTPFDEKQVKIGRRLLTKLWnasRFVlhFSADPEPDKAEVLEPLDRWILAKLAKVV 623
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 812 EGVREDYAALRNNTAAAKLIEYTNH--------LTK----------EGVAARAA----IEPLVLMVAPLAPHLAEELWKR 869
Cdd:PRK13208 624 EKATEALENYDFAKALEEIESFFWHvfcddyleLVKsraygedeeeEQKSARYTlytvLDTLLRLLAPFLPFITEEVWSW 703
|
970 980 990 1000
....*....|....*....|....*....|....*....|
gi 118170488 870 LgHDTSLAHGPFPEADPQYLVEDTIEFP---VQVNGKVRG 906
Cdd:PRK13208 704 L-YGGSVHRASWPEPDEELIDEEDEELGelaKEILSAVRK 742
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
764-870 |
2.70e-35 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 130.03 E-value: 2.70e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 764 WATKDVVGAHRFLQRVWRVVIDETSGNVRVVEHEALSDET---LRLLHRTIEGVREDYAALRNNTAAAKLIEYTNHLTK- 839
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAAAELSEEDkelRRKLHKTIKKVTEDIERLRFNTAIAALMELVNALYKy 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 118170488 840 ------EGVAARAAIEPLVLMVAPLAPHLAEELWKRL 870
Cdd:cd07958 81 kkkdaqHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
31-751 |
5.38e-31 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 129.84 E-value: 5.38e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 31 AWQETWSDRGTFNvanpvgslaPTDGSDVPADKMFVQDMFPYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFD 110
Cdd:pfam00133 1 QIYEFWDEQGYFK---------PELEKRKGKPSFTIHDGPPNATGS-LHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 111 AFGLPAEQ-----YAVQTGTHPRTRTEANIVNF------------RRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQI 173
Cdd:pfam00133 71 HHGLPTEQvvekkLGIKEKKTRHKYGREEFREKcrewkmeyadeiRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 174 YNawfdrdqnkarriselveefesgkrtlddgrnwadlsKGeradvidgyrLVYRADSMVNWCPGLGTVLANEEVTsegr 253
Cdd:pfam00133 151 HD-------------------------------------KG----------LIYRGKKLVNWSPALNTALSNLEVE---- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 254 sdrgnfpvfrkrlrqwmmritaYSDrlledldvldwpekvktmqrnwigrSTGASVLFATAADD-----IEVFTTRPDTL 328
Cdd:pfam00133 180 ----------------------YKD-------------------------VKGPSIHVAFPLADdegasLVIWTTTPWTL 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 329 FGATYLVLAPEHDLVdtlvtdawpdgTDERWTYGAATPREAVAAYRTDIAAKSDLERQEnktktgvFLGAYATNPADGKQ 408
Cdd:pfam00133 213 PGNTAVAVNPEFDYV-----------ITGEGYILAEALLKSLYKKGTDKKILEDFRGKE-------LEGKEAIHPFVNRE 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 409 VPIFIADYVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTggdiseaayaGDGTMVNS-GFLDGMDVASAKEAIIA 487
Cdd:pfam00133 275 IPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVD----------DDGTFTEEaPDFQGVYRFDARKKIVE 344
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 488 RLEADG----------------RGKRRVEYKL----------------------------------------RDWLFARQ 511
Cdd:pfam00133 345 LLTEKGlllkiepfthsypfcwRSGTPIIPRAtpqwfvrmdeladqaleavekvqfvpksgekryfnwlaniQDWCISRQ 424
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 512 RYWGEPFPIVYDAD-GRAHPLPESALPVELpdvpdyspvLFDPDDADSepspplnkateWVHVEL--DLGDGLQSYTRDT 588
Cdd:pfam00133 425 RWWGHPIPAWVSKDtEEVVCRGELFELVAG---------RFEEEGSIK-----------WLHREAkdKLGYGKGTLEQDE 484
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 589 NVMPQWAGS-SWYelrYTDPHNPDEMcAKENEAYWmgprpdehgpedpgGVDLYVGGVEHavlhllySRFWHKVLYDLG- 666
Cdd:pfam00133 485 DVLDTWFSSgSWP---FSTLGWPFVN-TEEFKKFF--------------PADMLLEGSDQ-------TRGWFYRMIMLSt 539
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 667 YVSSREPYRRLVNQGYIqafaytdsrgtyvpaaevieRDGkffwpgpDGEievnqefgKIGKSLKNSVSPDEICDNYGAD 746
Cdd:pfam00133 540 ALTGSVPFKNVLVHGLV--------------------RDE-------QGR--------KMSKSLGNVIDPLDVIDKYGAD 584
|
....*
gi 118170488 747 TLRVY 751
Cdd:pfam00133 585 ALRLW 589
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
78-895 |
5.14e-27 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 118.43 E-value: 5.14e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 78 LHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLP----AEQ---------------YAVQTGTHPRTRTEANIVNF 138
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERiargdpetielykslYGIPEEELEKFKDPEYIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 139 -----RRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYnawfdrdqnkarriselveefesgkrtlddgrnwadlSK 213
Cdd:PRK12300 81 fseeaKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLK-------------------------------------EK 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 214 GeradvidgyrLVYRADSMVNWCPglgtvlaneevtsegrsdRGNFPVfrkrlrqwmmritaysdrllEDLDVLDwPEKV 293
Cdd:PRK12300 124 G----------LIVKGSHPVRYCP------------------NDNNPV--------------------GDHDLLD-GEEP 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 294 KTMQRNWIGRSTGASVLFATAaddievfTTRPDTLFGATYLVLAPEHDLVDTLVTDawpdgtdERWtygaATPREAvaay 373
Cdd:PRK12300 155 EIVEYTLIKFEESEDLILPAA-------TLRPETIFGVTNLWVNPDATYVKAEVDG-------EKW----IVSKEA---- 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 374 rtdiAAKsdLERQEN------KTKTGVFLGAYATNPADGKQVPIFIADYVLAGYGTGAIMAVPG------------GDQR 435
Cdd:PRK12300 213 ----AEK--LSFQDRdveiieEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAhapydyvalrdlKKNK 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 436 DWDFAKEFgLPIIEV-----VTGGDISEAA---------------------YAGdGTM-VNSGFLDGMDVASAKEAIIAR 488
Cdd:PRK12300 287 ELLDVIEP-IPLIEVegygeFPAKEVVEKLgiksqedpeleeatkevyraeFHK-GVLkENTGEYAGKPVREAREKITKD 364
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 489 LEADGRG-------------------------------------KRRV------------EYK---------LRDWLFAR 510
Cdd:PRK12300 365 LIEKGIAdimyefsnrpvycrcgtecvvkvvkdqwfidysdpewKELAhkaldnmeiipeEYRkefentidwLKDRACAR 444
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 511 QRYWGEPFP--------------------IVydadgrAHPLPESALPVEL--PDVPDYspVLFDPDDADsEPSpplnkat 568
Cdd:PRK12300 445 RRGLGTRLPwdeewiieslsdstiymayyTI------AHKIREYGIKPEQltPEFFDY--VFLGKGDPE-EVS------- 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 569 ewvhveldlgdglqsytRDTNVmpqwagsswyelrytdPHNPDEMCAKENEaYWMGprpdehgpedpggVDLYVGGVEHA 648
Cdd:PRK12300 509 -----------------KKTGI----------------PKEILEEMREEFL-YWYP-------------VDWRHSGKDLI 541
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 649 VLHLLYSRFWHKVLYDlgyvssREPY-RRLVNQGYIQafaytdsrgtyvpaaevieRDGKffwpgpdgeievnqefgKIG 727
Cdd:PRK12300 542 PNHLTFFIFNHVAIFP------EEKWpRGIVVNGFVL-------------------LEGK-----------------KMS 579
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 728 KSLKNSVSPDEICDNYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRvWRVVIDETSGNVRVVEHEALSDETLRLL 807
Cdd:PRK12300 580 KSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLER-FYELAKELIEIGGEEELRFIDKWLLSRL 658
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 808 HRTIEGVREDYAALRNNTAAAK----LIEYTNH---LTKEGV--AARAAIEPLVLMVAPLAPHLAEELWKRLGHDTSLAH 878
Cdd:PRK12300 659 NRIIKETTEAMESFQTRDAVQEafyeLLNDLRWylrRVGEANnkVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSL 738
|
970
....*....|....*..
gi 118170488 879 GPFPEADpQYLVEDTIE 895
Cdd:PRK12300 739 EKWPEPD-ESKIDEEAE 754
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
71-904 |
1.30e-19 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 94.75 E-value: 1.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 71 PYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQT-GTHPRTRTEANIV-NFRR-------- 140
Cdd:TIGR00392 45 PYANGS-IHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTHGLPIEHKVEKKlGISGKKEISSLEIeEFREkcrefalk 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 141 -------QLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYnawfdrdqnkarriselveefesgkrtlddgrnwadlSK 213
Cdd:TIGR00392 124 qieeqreQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAH-------------------------------------EK 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 214 GeradvidgyrLVYRADSMVNWCPGLGTVLANEEVtsegrsdrgNFPVFRKRLRQwmmrITAYSDRLLEDLDVLDWPEKV 293
Cdd:TIGR00392 167 G----------LLYRGLKPVYWSPRCRTALAEAEV---------EYKENYKDVKD----PSIYVKFPVKKDKKTYLKVKL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 294 KTmqrnwigrstgasvlfataaddIEVFTTRPDTLFGATYLVLAPEHDLVdtLVTDawpDGTDERWtygaatpreavaay 373
Cdd:TIGR00392 224 SS----------------------LLIWTTTPWTLPSNLAIAVHPDFEYA--LVQD---NTKVEYF-------------- 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 374 rtdIAAKSDLERQENK-----TKTGVFLGA-----YATNPADGKQVP-------IFIADYVLAGYGTGAIMAVPGGDQRD 436
Cdd:TIGR00392 263 ---ILAKKLVEKLYNKagsdyEIIKTFKGSdleglEYEHPLYDFVSQlkegapvVIGGDHVTTEDGTGIVHTAPGHGEED 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 437 WDFAKEFGLPIIEVV-TGGDISEAAYAGDGTMVNsgfLDGMDVASAKEAIIARLEADG----------------RGKRRV 499
Cdd:TIGR00392 340 YEIGKKYGLEVLSPVdEKGVYTEGVNDFQGRFVK---DADKDIIKANKIIIEQLKDKGlllkaekithsyphcwRTKTPV 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 500 EYK----------------------------------------LRDWLFARQRYWGEPFPIVYDADGrAHPLPESALPvE 539
Cdd:TIGR00392 417 IYRateqwfiktkdikdqmleqikkvnwvpewgegrfgnwlenRPDWCISRQRYWGIPIPIWYCEDT-GEPIVVGSIE-E 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 540 LPDVPDYSPVLFDPDDADsepSPPLNKATEwvhvelDLGDGlQSYTRDTNVMPQW--AGSSWYELRytdpHNPDEMCAKe 617
Cdd:TIGR00392 495 LIELIELKGIDAWFEDLH---RDFLDKITL------KSGDG-GEYRRVPDVLDVWfdSGSMPYASI----HYPFENEKF- 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 618 neaywmgprpDEHGPedpggVDLYVGGVEHavlhllySRFWHKVLYDLGYVSSRE-PYRRLVNQGYIqafayTDSRGTyv 696
Cdd:TIGR00392 560 ----------KEVFP-----ADFILEGSDQ-------TRGWFYSSLAIGTALFGQaPYKNVITHGFT-----LDEKGR-- 610
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 697 paaevierdgkffwpgpdgeievnqefgKIGKSLKNSVSPDEICDNYGADTLRVYeMSMgpleaSRPWAT--------KD 768
Cdd:TIGR00392 611 ----------------------------KMSKSLGNVVDPLKVINKYGADILRLY-VAS-----SDPWEDlrfsdeilKQ 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 769 VV--------GAHRFLqrVWRVVIDETSGNVRVVEHEALSDETLRLLHRT---IEGVREDYAALRNNTA----------- 826
Cdd:TIGR00392 657 VVekyrkirwNTYRFL--LTYANLDKFDPLFNSVAVEKFPEEDRWILSRLnslVEEVNEALEKYNFHKVlralqdfivee 734
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 827 -------AAKLIEYTNHLTKEGVAARA----AIEPLVLMVAPLAPHLAEELWKRL--GHDTSLAH-GPFPEADPQYlVED 892
Cdd:TIGR00392 735 lsnwyirIIRDRLYCEAKDNDKRAAQTtlyyALLTLVRLLAPFLPHTAEEIYQNLpgGEEEESVHlNLWPEVDEEF-IDE 813
|
970
....*....|..
gi 118170488 893 TIEFPVQVNGKV 904
Cdd:TIGR00392 814 ALEANMAIVREI 825
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
71-301 |
9.24e-19 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 89.61 E-value: 9.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 71 PYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAV-QTGTHPRTR---------------TEAN 134
Cdd:cd00817 10 PNVTGS-LHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEkKLGIEGKTRhdlgreeflekcwewKEES 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 135 IVNFRRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYNawfdrdqnkarriselveefesgkrtlddgrnwadlsKG 214
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYE-------------------------------------KG 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 215 eradvidgyrLVYRADSMVNWCPGLGTVLANEEVtsegrSDRGNFPVFRKRLRQWMMRITAYSDRLLEDL--DVLDW-PE 291
Cdd:cd00817 132 ----------LIYRDNRLVNWCPKLRTAISDIEV-----CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVkeGDIKFvPE 196
|
250
....*....|
gi 118170488 292 KVKTMQRNWI 301
Cdd:cd00817 197 RMEKRYENWL 206
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
70-301 |
2.11e-17 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 85.42 E-value: 2.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 70 FPYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGH 149
Cdd:pfam09334 7 LPYANGP-PHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKKFNISF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 150 DTrrsF-STTDVDYYKWTQWIFLQIYNAWFdrdqnkarrISELVEEfesGKRTLDDGRNWAD--------LSKGERAdvi 220
Cdd:pfam09334 86 DD---YgRTTSERHHELVQEFFLKLYENGY---------IYEKEIE---QFYCPSDERFLPDryvegtcpHCGSEDA--- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 221 dgyrlvyRADSmvnwCPGLGTVLANEEVTSEGRSDRGNFPVFRKRlRQWMMRITAYSDRLLE--DLDVLDWPEKVKTMQR 298
Cdd:pfam09334 148 -------RGDQ----CENCGRHLEPTELINPKCVICGTTPEVKET-EHYFFDLSKFQDKLREwiEENNPEWPENVKNMVL 215
|
...
gi 118170488 299 NWI 301
Cdd:pfam09334 216 EWL 218
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
27-493 |
5.07e-17 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 86.31 E-value: 5.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 27 QIERAWQETWSDRGTFnvanpvgslAPTDGSDVPadkmFVQdMFPYPSGDG-LHVGHPLGYIATDVYARYYRMLGRNVL- 104
Cdd:PRK05729 13 EVEAKWYQKWEEKGYF---------KPDDNSKKP----FSI-VIPPPNVTGsLHMGHALNNTLQDILIRYKRMQGYNTLw 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 105 -----HA---------------------LGFDAFgLP-----AEQYAvqtGThprtrteanIVNfrrQLGRLGLGhdtrr 153
Cdd:PRK05729 79 lpgtdHAgiatqmvverqlaaegksrhdLGREKF-LEkvwewKEESG---GT---------ITN---QLRRLGAS----- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 154 sfsttdVDYykwtqwiflqiynawfDRdqnkarriselvEEFesgkrTLDDGrnwadLSKGERADVIDGYR--LVYRADS 231
Cdd:PRK05729 138 ------CDW----------------SR------------ERF-----TMDEG-----LSKAVREVFVRLYEkgLIYRGKR 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 232 MVNWCPGLGTVLANEEVtsEGRSDRGNFpvfrkrlrqWMMRitaYSdrlLEDLDvldwpekvktmqrnwigrstgasvlf 311
Cdd:PRK05729 174 LVNWDPKLQTALSDLEV--EYKEVKGKL---------WHIR---YP---LADGS-------------------------- 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 312 ataaDDIEVFTTRPDTLFGATYLVLAPEhdlvdtlvtdawpdgtDERwtygaatpreavaaYRtdiaaksDLerqenktk 391
Cdd:PRK05729 211 ----DYLVVATTRPETMLGDTAVAVNPE----------------DER--------------YK-------HL-------- 241
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 392 tgvfLGAYATNPADGKQVPIfIAD-YVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTGgdiseaayagDGTMV-N 469
Cdd:PRK05729 242 ----IGKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDE----------DGTINeN 306
|
490 500
....*....|....*....|....
gi 118170488 470 SGFLDGMDVASAKEAIIARLEADG 493
Cdd:PRK05729 307 PGEYQGLDRFEARKAIVADLEELG 330
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
71-301 |
5.84e-16 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 82.08 E-value: 5.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 71 PYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHD 150
Cdd:COG0143 10 PYANGP-PHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELFEKLGISFD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 151 TrrsF-STTDVDYYKWTQWIFLQIYNA----------WFDrdqnkarriselveefesgkrtLDDGRNWADlskgeradv 219
Cdd:COG0143 89 N---FiRTTSPEHKELVQEIFQRLYDNgdiykgeyegWYC----------------------PECERFLPD--------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 220 idgyRLV-------YRADSMVNWCPGLGTVLANEEVTSEGRSDRGNFPVFRKRlRQWMMRITAYSDRLLEDLDVL-DWPE 291
Cdd:COG0143 135 ----RYVegtcpkcGAEDAYGDQCENCGATLEPTELINPRSAISGAPPELREE-EHYFFRLSKYQDRLLEWIEENpDIQP 209
|
250
....*....|
gi 118170488 292 KVKTMQRNWI 301
Cdd:COG0143 210 EVRNEVLSWL 219
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
71-301 |
6.07e-16 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 79.88 E-value: 6.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 71 PYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHD 150
Cdd:cd00814 9 PYVNGV-PHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFKWLNISFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 151 TrrsFS-TTDVDYYKWTQWIFLQIYNAwfdrdqnkarriselveefesgkrtlddgrnwADLSKGEradvidgYRLVYra 229
Cdd:cd00814 88 Y---FIrTTSPRHKEIVQEFFKKLYEN--------------------------------GYIYEGE-------YEGLY-- 123
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 118170488 230 dsmvnwCPglgtvlaneevtsegrSDRGNFPVFRKRlRQWMMRITAYSDRLLEDLD---VLDWPEKVKTMQRNWI 301
Cdd:cd00814 124 ------CV----------------SCERFLPEWREE-EHYFFRLSKFQDRLLEWLEknpDFIWPENARNEVLSWL 175
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
21-889 |
3.20e-15 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 80.51 E-value: 3.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 21 NADLAgQIERAWQETWSDRGTFNvanpvGSLAPTDGSdvpadKMFVqdmF----PYPSGDgLHVGHPLGYIATDVYARYY 96
Cdd:COG0060 15 RANLP-KREPEILKFWEENDIYE-----KSREARAGR-----PKFV---LhdgpPYANGD-IHIGHALNKILKDIIVRYK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 97 RMLGRNVLHALGFDAFGLPAEQyAV--QTGTHPRTRTEANIVNFR------------------RQLGRLGlghDTRRSFS 156
Cdd:COG0060 80 TMRGFDVPYVPGWDCHGLPIEL-KVekELGIKKKDIEKVGIAEFRekcreyalkyvdeqredfKRLGVWG---DWDNPYL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 157 TTDVDYykwtqwiflqIYNAWfdrdqnkarriselvEEFesgKRTLDDGrnwadlskgeradvidgyrLVYRADSMVNWC 236
Cdd:COG0060 156 TMDPEY----------EESIW---------------WAL---KKLYEKG-------------------LLYKGLKPVPWC 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 237 PGLGTVLANEEVTsegrsdrgnfpvfrkrlrqwmmritaYSDRllED--LDVldwpeKVKTMQRNWIGRSTGASVLfata 314
Cdd:COG0060 189 PRCGTALAEAEVE--------------------------YKDV--TSpsIYV-----KFPVKDEKALLLLEDAYLV---- 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 315 addieVFTTRPDTLFGATYLVLAPEHD--LVDTlvtdawpdGTDERWtygaatpreavaayrtdIAAKSDLE------RQ 386
Cdd:COG0060 232 -----IWTTTPWTLPANLAVAVHPDIDyvLVEV--------TGGERL-----------------ILAEALVEavlkelGI 281
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 387 ENKTKTGVFLGA----------YATNPADGKQVPIFIADYVLAGYGTGAI-MAvPGGDQRDWDFAKEFGLPIIEVVtggd 455
Cdd:COG0060 282 EDYEVLATFKGAeleglryehpFYYVVGYDRAHPVILGDYVTTEDGTGIVhTA-PGHGEDDFEVGKKYGLPVLNPV---- 356
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 456 iseaayAGDGTMVNS-GFLDGMDVASAKEAIIARLEADGR---------------------------------------- 494
Cdd:COG0060 357 ------DDDGRFTEEaPLFAGLFVKDANPAIIEDLKERGAllarekithsyphcwrcktpliyratpqwfismdklrdra 430
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 495 -------------GKRR----VEyKLRDWLFARQRYWGEPFPIVYDAD-GRAHPLPES----ALPVElpdvpdyspvlfd 552
Cdd:COG0060 431 leaiekvnwipewGEGRfgnmLE-NRPDWCISRQRYWGVPIPIWVCEDcGELHRTEEVigsvAELLE------------- 496
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 553 pdDADSEPSPPLNKATEWVHVELDLGDGLQSYTRDTNVMPQW--AGSSWYelrytdphnpdemCAKENeaywmgpRPDEH 630
Cdd:COG0060 497 --EEGADAWFELDLHRPFLDETLKCPKCGGTMRRVPDVLDVWfdSGSMHF-------------AVLEN-------REELH 554
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 631 GPedpggVDLYVGGV-EHavlhllysRFW-HkvlydlgyvSS---------REPYRRLVNQGYIQafaytDSrgtyvpaa 699
Cdd:COG0060 555 FP-----ADFYLEGSdQT--------RGWfY---------SSlltstalfgRAPYKNVLTHGFVL-----DE-------- 599
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 700 evierDGKffwpgpdgeievnqefgKIGKSLKNSVSPDEICDNYGADTLRVYEMSmgpleaSRPWA--------TKDVVg 771
Cdd:COG0060 600 -----DGR-----------------KMSKSLGNVVDPQEVIDKYGADILRLWVAS------SDYWGdlrfsdeiLKEVR- 650
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 772 ahRFLQRVWRVV------IDETSGNVRVVEHEALSDE---TLRLLHRTIEGVREDYAALRNNTAAAKLIEY-TNHLT--- 838
Cdd:COG0060 651 --DVYRRLRNTYrfllanLDDFDPAEDAVPYEDLPELdrwILSRLNELIKEVTEAYDNYDFHRAYRALHNFcVEDLSnwy 728
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118170488 839 ------------KEGVAARAA-------IEPLVLMVAPLAPHLAEELWKRLGHDTS----LAhgPFPEADPQYL 889
Cdd:COG0060 729 ldiskdrlyteaADSLDRRAAqttlyevLETLVRLLAPILPFTAEEIWQNLPGEAEesvhLA--DWPEVDEELI 800
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
63-176 |
1.16e-14 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 75.92 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 63 KMFVQDMFPYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTH-------------PRT 129
Cdd:cd00668 1 KFYVTTPPPYANGS-LHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRkkktiwieefredPKE 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 118170488 130 RTEANIVNFRRQLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYNA 176
Cdd:cd00668 80 FVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEK 126
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
28-490 |
5.20e-14 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 76.58 E-value: 5.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 28 IERAWQETWSDRGTFNVANPVGSLaptdgsdvPADKMFVQdMFPYPSGDG-LHVGHPLGYIATDVYARYYRMLGRNVLHA 106
Cdd:PTZ00419 33 VESGWYEWWEKSGFFKPAEDAKSL--------NSGKKFVI-VLPPPNVTGyLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 107 LGFDAFGLpAEQYAV--------QTGTHPRTRTE-------------ANIVNfrrQLGRLGLGHDTRRSFSTTDvdyykw 165
Cdd:PTZ00419 104 PGTDHAGI-ATQVVVekklmkeeNKTRHDLGREEflkkvwewkdkhgNNICN---QLRRLGSSLDWSREVFTMD------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 166 tqwiflqiynawfdrDQNKARRISELVEEFESGkrtlddgrnwadlskgeradvidgyrLVYRADSMVNWCPGLGTVLAN 245
Cdd:PTZ00419 174 ---------------EQRSKAVKEAFVRLYEDG--------------------------LIYRDTRLVNWCCYLKTAISD 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 246 EEVtsegrsdrgNFPVFRKRLrqwMMRITAYsDRLLEdLDVLdWPEKVKTMQRNwigrstgasvlfataADDIEVFTTRP 325
Cdd:PTZ00419 213 IEV---------EFEEIEKPT---KITIPGY-DKKVE-VGVL-WHFAYPLEDSG---------------QEEIVVATTRI 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 326 DTLFGATYLVLAPEhdlvdtlvtdawpdgtDERWTYgaatpreavaayrtdiaaksdlerqenktktgvFLGAYATNP-A 404
Cdd:PTZ00419 263 ETMLGDVAVAVHPK----------------DERYKK---------------------------------LHGKELIHPfI 293
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 405 DGKQVPIfIAD--YVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTggdiseaayaGDGTM-VNSGFLDGMDVASA 481
Cdd:PTZ00419 294 PDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFT----------LDGKInENGGEFAGMHRFDC 362
|
....*....
gi 118170488 482 KEAIIARLE 490
Cdd:PTZ00419 363 RRKIEEELK 371
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
804-910 |
5.97e-14 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 69.74 E-value: 5.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 804 LRLLHRTIEGVREDYAALRNNTAAAKLIEYTNH-------------LTKEGVAARA------AIEPLVLMVAPLAPHLAE 864
Cdd:pfam08264 5 LSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNdlsdwylelikdrLYGEEPDSRAqttlyeVLETLLRLLAPFMPFITE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 118170488 865 ELWKRLghdtSLAHGPFPEADPQYLVEDTIEF-----PVQVNGKVRGKIVV 910
Cdd:pfam08264 85 ELWQKE----SIHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKI 131
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
27-493 |
9.93e-14 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 75.47 E-value: 9.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 27 QIERAWQETWSDRGTFnvanpvgslAPTDGSDVPAdkmFVQdMFPYPSGDG-LHVGHPLGYIATDVYARYYRMLGRNVL- 104
Cdd:COG0525 11 EVEAKWYQYWEENGYF---------KADPDSDKEP---FTI-VIPPPNVTGsLHMGHALNNTLQDILIRYKRMQGYNTLw 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 105 -----HA---------------------LGFDAFgLP-----AEQYAvqtGThprtrteanIVNfrrQLGRLGLGhdtrr 153
Cdd:COG0525 78 qpgtdHAgiatqavverqlaeegksrhdLGREKF-LErvwewKEESG---GT---------ITN---QLRRLGAS----- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 154 sfsttdVDYykwtqwiflqiynawfDRdqnkarriselvEEFesgkrTLDDGrnwadLSKGERADVIDGYR--LVYRADS 231
Cdd:COG0525 137 ------CDW----------------SR------------ERF-----TMDEG-----LSKAVREVFVRLYEkgLIYRGKR 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 232 MVNWCPGLGTVLANEEVTSEGRSdrGNFpvfrkrlrqWMMRitaYSdrlLEDldvldwpekvktmqrnwigrstgasvlf 311
Cdd:COG0525 173 LVNWDPKLKTALSDLEVEHEEVK--GHL---------WHIR---YP---LAD---------------------------- 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 312 atAADDIEVFTTRPDTLFGATYLVLAPEhdlvdtlvtdawpdgtDERwtygaatpreavaaYRtdiaaksDLerqenktk 391
Cdd:COG0525 208 --GSGYIVVATTRPETMLGDTAVAVHPE----------------DER--------------YK-------HL-------- 240
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 392 tgvfLGAYATNPADGKQVPIfIAD-YVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTggdiseaayaGDGTMV-N 469
Cdd:COG0525 241 ----IGKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILD----------EDGTINeN 305
|
490 500
....*....|....*....|....
gi 118170488 470 SGFLDGMDVASAKEAIIARLEADG 493
Cdd:COG0525 306 AGKYRGLDRFEARKAIVADLEELG 329
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
29-889 |
2.16e-12 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 71.34 E-value: 2.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 29 ERAWQETWSDRGTFNVAnpvgslaptdgSDVPADKMFV-QDMFPYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHAL 107
Cdd:PLN02843 9 EPEIQKLWEENQVYKRV-----------SDRNNGESFTlHDGPPYANGD-LHIGHALNKILKDFINRYQLLQGKKVHYVP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 108 GFDAFGLPAEQYAVQTgthprTRTEAnivnfRRQLGRLGLgHDTRRSFSTTDVDyykwTQWIFLQIYNAWFDrdqnkarr 187
Cdd:PLN02843 77 GWDCHGLPIELKVLQS-----LDQEA-----RKELTPIKL-RAKAAKFAKKTVD----TQRESFKRYGVWGD-------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 188 iselveeFESGKRTLDDGRNWADLSK-GERAdvIDGYrlVYRADSMVNWCPGLGTVLANEEVT-SEGRSDRGNFPVFrkr 265
Cdd:PLN02843 134 -------WENPYLTLDPEYEAAQIEVfGQMF--LNGY--IYRGRKPVHWSPSSRTALAEAELEyPEGHVSKSIYVAF--- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 266 lrqwmmRITAYSDRLLEDLDvldwpEKVKtmqrnwigrstGASVlfataaddiEVFTTRPDTLFGATYLVLAPEHDL--- 342
Cdd:PLN02843 200 ------PVVSPSETSPEELE-----EFLP-----------GLSL---------AIWTTTPWTMPANAAVAVNDKLQYsvv 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 343 -VDTLVTDAWPDGTDERWTYGAATPREA-----VAA-YRTDIAAKSDLERQENKTKTGVFL-GAYATNPADGKQVPIFIA 414
Cdd:PLN02843 249 eVQSFSEDESTSGGNKKKRPGNVLKEQQklfliVATdLVPALEAKWGVKLVVLKTFPGSDLeGCRYIHPLYNRESPVVIG 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 415 -DYVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVV--------TGGDISEAAYAGDGTMVNSGFLDGMDVASAKEAI 485
Cdd:PLN02843 329 gDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVddagkfteEAGQFSGLSVLGEGNAAVVEALDEAGSLLMEEAY 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 486 IARLEADGRGK--------------------------RRVEY-------KLR-------DWLFARQRYWGEPFPIVYDAD 525
Cdd:PLN02843 409 GHKYPYDWRTKkptifrateqwfasvegfrqaaldaiDKVKWipaqgenRIRamvsgrsDWCISRQRTWGVPIPVFYHVE 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 526 GRAhplpesalpvelpdvpdyspVLFDPDDADSEPSPPLNKATE--WvhvELDLGDGL--------QSYTRDTNVMPQW- 594
Cdd:PLN02843 489 TKE--------------------PLMNEETIAHVKSIVAQKGSDawW---YMDVEDLLpekyrdkaSDYEKGTDTMDVWf 545
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 595 -AGSSWyelrytdphnpdemcakeneAYWMGPRPDEHGPedpggVDLYVGGVEHavlHllysRFWhkvlydlgYVSS--- 670
Cdd:PLN02843 546 dSGSSW--------------------AGVLGSREGLSYP-----ADLYLEGSDQ---H----RGW--------FQSSllt 585
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 671 ------REPYRRLVNQGYIqafayTDSRGTyvpaaevierdgkffwpgpdgeievnqefgKIGKSLKNSVSPDEICDN-- 742
Cdd:PLN02843 586 svatkgKAPYKSVLTHGFV-----LDEKGF------------------------------KMSKSLGNVVDPRLVIEGgk 630
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 743 -------YGADTLRVYEMSMGpleasrpwATKDV-VG---------AHRFLQRVWRVVIdetsGNV------RVVEHE-- 797
Cdd:PLN02843 631 nqkqepaYGADVLRLWVASVD--------YTGDVlIGpqilkqmsdIYRKLRGTLRYLL----GNLhdwkpdNAVPYEdl 698
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 798 -ALSDETLRLLHRTIEGVREDY-----------------AALRN---NTAAAKL-IEYTNHLTK---EGVAArAAIEPLV 852
Cdd:PLN02843 699 pSIDKYALFQLENVVNEIEESYdnyqffkifqilqrftiVDLSNfylDVAKDRLyVGGTTSFTRrscQTVLA-AHLLSLL 777
|
970 980 990 1000
....*....|....*....|....*....|....*....|...
gi 118170488 853 LMVAPLAPHLAEELWKRL--GHDTSLAHGPF----PEADPQYL 889
Cdd:PLN02843 778 RAIAPILPHLAEDAWQNLpfQEDGSAAESVFeagwPTPNEEWL 820
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
65-504 |
9.20e-11 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 66.12 E-value: 9.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 65 FVQDMFPYPSGDGLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLpAEQYAVQtgthpRTRTEANIVnfRRQLGR 144
Cdd:PLN02943 90 FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI-ATQLVVE-----KMLASEGIK--RTDLGR 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 145 lglghdtrrsfsttdvDYYKWTQWIFLQIYNAWFdrdQNKARRISELVEeFESGKRTLDDGRNWADLSKGERadvIDGYR 224
Cdd:PLN02943 162 ----------------DEFTKRVWEWKEKYGGTI---TNQIKRLGASCD-WSRERFTLDEQLSRAVVEAFVR---LHEKG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 225 LVYRADSMVNWCPGLGTVLANEEVtsEGRSDRGNFPVFRKRLrqwmmritaysdrlledldvldwpekvktmqrnwigrs 304
Cdd:PLN02943 219 LIYQGSYMVNWSPNLQTAVSDLEV--EYSEEPGTLYYIKYRV-------------------------------------- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 305 TGASVLFATAAddievfTTRPDTLFGATYLVLAPEhdlvdtlvtdawpdgtDERWTYgaatpreavaayrtdiaaksdle 384
Cdd:PLN02943 259 AGGSEDFLTIA------TTRPETLFGDVAIAVNPE----------------DDRYSK----------------------- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 385 rqenktktgvFLGAYATNPAD-GKQVPIFIADYVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTggdiseaayaG 463
Cdd:PLN02943 294 ----------YIGKMAIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMN----------K 353
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 118170488 464 DGTMVNSGfldGMDVASAKEAIIARLEADGRGKRRVEYKLR 504
Cdd:PLN02943 354 DGTLNEVA---GLYWFEAREKLWSDLEETGLAVKKEPHTLR 391
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
27-493 |
1.83e-10 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 65.01 E-value: 1.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 27 QIERAWQETWSDRGTFNvanpvgslaptdGSDVPADKMFVQDMFPYPSGDG-LHVGHPLGYIATDVYARYYRMLGRNVLH 105
Cdd:PRK14900 23 EVEARWYPFWQERGYFH------------GDEHDRTRPPFSIVLPPPNVTGsLHLGHALTATLQDVLIRWKRMSGFNTLW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 106 ALGFDAFGLpAEQYAVQtgtHPRTRTEANIvnfRRQLGRLGlghdtrrsfsttdvdyykwtqwiFLQIYNAWFDR----- 180
Cdd:PRK14900 91 LPGTDHAGI-ATQMIVE---KELKKTEKKS---RHDLGREA-----------------------FLERVWAWKEQygsri 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 181 -DQNKARRISElveEFESGKRTLDDGrnwadLSKGERADVIDGYR--LVYRADSMVNWCPGLGTVLANEEVTSEgRSDRG 257
Cdd:PRK14900 141 gEQHKALGASL---DWQRERFTMDEG-----LSRAVREVFVRLHEegLIYREKKLINWCPDCRTALSDLEVEHE-EAHQG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 258 NFPVFRKRLrqwmmritaysdrlledldvldwpekvktmqrnwigrstgasvlfATAADDIEVFTTRPDTLFGATYLVLA 337
Cdd:PRK14900 212 ELWSFAYPL---------------------------------------------ADGSGEIVVATTRPETMLGDTAVAVH 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 338 PEhdlvdtlvtdawpdgtDERwtygaatpreavaaYRTdiaaksdlerqenktktgvFLGAYATNPADGKQVPIfIADYV 417
Cdd:PRK14900 247 PL----------------DPR--------------YMA-------------------LHGKKVRHPITGRTFPI-VADAI 276
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 118170488 418 LAG--YGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVtggdiseaayAGDGTMVN-SGFLDGMDVASAKEAIIARLEADG 493
Cdd:PRK14900 277 LVDpkFGTGAVKVTPAHDFNDFEVGKRHGLEMITVI----------GPDGRMTAeAGPLAGLDRFEARKEVKRLLAEQG 345
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
71-176 |
2.24e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 61.05 E-value: 2.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 71 PYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHD 150
Cdd:PRK11893 10 YYPNGK-PHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEALNISYD 88
|
90 100
....*....|....*....|....*..
gi 118170488 151 trrSFS-TTDVDYYKWTQWIFLQIYNA 176
Cdd:PRK11893 89 ---DFIrTTDPRHKEAVQEIFQRLLAN 112
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
17-503 |
7.51e-09 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 59.91 E-value: 7.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 17 RHRYNADLAGQ-----IERAWQETWSDRGTFnVANPVGSLAPtdgsdvpadkmFVQdMFPYPSGDG-LHVGHPLGYIATD 90
Cdd:PLN02381 89 KKRLSSQMAKQyspsaVEKSWYAWWEKSGYF-GADAKSSKPP-----------FVI-VLPPPNVTGaLHIGHALTAAIED 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 91 VYARYYRMLGRNVLHALGFDAFGLpAEQYAVqtgthprtrtEANIVNfRRQLGRlglgHDTRRSFSTTDVdyYKWtqwif 170
Cdd:PLN02381 156 TIIRWKRMSGYNALWVPGVDHAGI-ATQVVV----------EKKLMR-ERHLTR----HDIGREEFVSEV--WKW----- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 171 lqiynawfdRDQ------NKARRISELV----EEFesgkrTLDDGRnwadlSKGERADVIDGYR--LVYRADSMVNWCPG 238
Cdd:PLN02381 213 ---------KDEyggtilNQLRRLGASLdwsrECF-----TMDEQR-----SKAVTEAFVRLYKegLIYRDIRLVNWDCT 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 239 LGTVLANEEVTsegrsdrgnfpvfrkrlrqwmmritaYSDrlLEDLDVLDWPEKVKTMQrnwIGRSTGASVLFATAADDI 318
Cdd:PLN02381 274 LRTAISDVEVD--------------------------YID--IKERTLLKVPGYDKPVE---FGVLTSFAYPLEGGLGEI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 319 EVFTTRPDTLFGATYLVLAPEhdlvdtlvtdawpdgtDERWTYgaatpreavaayrtdiaaksdlerqenktktgvFLGA 398
Cdd:PLN02381 323 VVATTRIETMLGDTAIAIHPD----------------DERYKH---------------------------------LHGK 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 399 YATNPADGKQVPIfIADYVLA--GYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTggdiseaayaGDGTMVNSGF--LD 474
Cdd:PLN02381 354 FAVHPFNGRKLPI-ICDAILVdpNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFT----------DDGKINSNGGseFA 422
|
490 500 510
....*....|....*....|....*....|.
gi 118170488 475 GMDVASAKEAIIARLEADG--RGKRRVEYKL 503
Cdd:PLN02381 423 GMPRFAAREAVIEALQKKGlyRGAKNNEMRL 453
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
71-301 |
3.68e-08 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 56.47 E-value: 3.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 71 PYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTG--THPRTRTEANIVNFR--------- 139
Cdd:cd00818 10 PYANGL-PHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELgiSGKKDIEKMGIAEFNakcrefalr 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 140 ------RQLGRLGLGHDTRRSFSTTDVDYYKWTQWIFLQIYNawfdrdqnkarriselveefesgkrtlddgrnwadlsK 213
Cdd:cd00818 89 yvdeqeEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHE-------------------------------------K 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 214 GeradvidgyrLVYRADSMVNWcpglgtvlaneevtsegrsdrgnfPVFRKRLRQWMMRITAYSDRLLEDLDVLDW-PEK 292
Cdd:cd00818 132 G----------LLYRGYKVVPW------------------------PLIYRATPQWFIRVTKIKDRLLEANDKVNWiPEW 177
|
....*....
gi 118170488 293 VKTMQRNWI 301
Cdd:cd00818 178 VKNRFGNWL 186
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
23-170 |
1.06e-07 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 56.23 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 23 DLAGQIERAWQETWSDRGTFNVAnpvgslaPTDGSDVPADKMFVQdmFPYPSGDG-LHVGHPLGYIATDVYARYYRMLGR 101
Cdd:PLN02959 13 DRLLEIEVAVQKWWEEEKVFEAE-------AGDEPPKPGEKFFGN--FPYPYMNGlLHLGHAFSLSKLEFAAAYHRLRGA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 102 NVLHALGFDAFGLP-----------AEQY---------------AVQTGTHPRTR------------------------- 130
Cdd:PLN02959 84 NVLLPFAFHCTGMPikasadklareIQQYgnppvfpeededeaaAVAAAKAEAEAaaappdkfkgkkskavaksgtqkyq 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 118170488 131 ---------TEANIVNFR--------------RQLGRLGLGHDTRRSFSTTDVD-YY-KWTQWIF 170
Cdd:PLN02959 164 weimrsfglPDSEIAKFQdpyhwlsyfpplakEDLKAFGLGCDWRRSFITTDVNpYYdAFVRWQF 228
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
71-176 |
1.23e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 55.54 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 71 PYPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTHPRTrteanIVN-----FRRQLGRL 145
Cdd:PRK00133 11 PYANGP-IHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPEE-----LIAryhaeHKRDFAGF 84
|
90 100 110
....*....|....*....|....*....|..
gi 118170488 146 GLGHDTrrsFSTTDVDY-YKWTQWIFLQIYNA 176
Cdd:PRK00133 85 GISFDN---YGSTHSEEnRELAQEIYLKLKEN 113
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
503-751 |
9.93e-06 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 48.77 E-value: 9.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 503 LRDWLFARQRYWGEPFPIVYDADGrahplpESALPVELPDVPDyspVLFDpddadsepspplnkatewvhveldlgdglq 582
Cdd:cd00818 189 RRDWCISRQRYWGTPIPVWYCEDC------GEVLVRRVPDVLD---VWFD------------------------------ 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 583 sytrdtnvmpqwAGSSWYELRytdpHNPDEmcAKENEAYWmgprpdehgpedPggVDLYVGGVEHavlhllySRFWHKVL 662
Cdd:cd00818 230 ------------SGSMPYAQL----HYPFE--NEDFEELF------------P--ADFILEGSDQ-------TRGWFYSL 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 663 YDLG-YVSSREPYRRLVNQGYIQAfaytdsrgtyvpaaevierdgkffwpgPDGEievnqefgKIGKSLKNSVSPDEICD 741
Cdd:cd00818 271 LLLStALFGKAPYKNVIVHGFVLD---------------------------EDGR--------KMSKSLGNYVDPQEVVD 315
|
250
....*....|
gi 118170488 742 NYGADTLRVY 751
Cdd:cd00818 316 KYGADALRLW 325
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
72-174 |
3.77e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 47.49 E-value: 3.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 72 YPSGDgLHVGHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHD- 150
Cdd:PRK12267 14 YPNGK-PHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKELWKKLDISYDk 92
|
90 100
....*....|....*....|....*
gi 118170488 151 -TRrsfsTTDVDYYKWTQWIFLQIY 174
Cdd:PRK12267 93 fIR----TTDERHKKVVQKIFEKLY 113
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
766-870 |
6.03e-05 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 43.70 E-value: 6.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 766 TKDVVGAHRFLQRVW---RVV---IDETSGNVRVVEHEALSDE-TLRLLHRTIEGVREDYAALRNNTAAAKLIEYTNH-- 836
Cdd:cd07962 3 EKRVEGGRNFCNKLWnaaRFVlmnLEDDDEPEEDPESLSLADRwILSRLNKTVEEVTEALENYRFSEAATALYEFFWNdf 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 118170488 837 ------LTK------EGVAARAAIEPL--VL-----MVAPLAPHLAEELWKRL 870
Cdd:cd07962 83 cdwyleLVKprlygeDEEEKKAARATLyyVLetilrLLHPFMPFITEELWQRL 135
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
725-892 |
2.78e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 45.10 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 725 KIGKSLKNSVSPDEICDNYGADTLRVYEMSmGPLEASRPW---------ATKDVV----GAHRFL-QRVWRvvIDETSGN 790
Cdd:PLN02882 614 KMSKSLKNYPDPNEVIDKYGADALRLYLIN-SPVVRAEPLrfkeegvfgVVKDVFlpwyNAYRFLvQNAKR--LEVEGGA 690
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 791 VRVVEHEALSDETLRLLHRTIEG--------VREDYAALRNNTAAAKLIEYTNHLT-------------KEGVA-ARAAI 848
Cdd:PLN02882 691 PFVPLDLAKLQNSANVLDRWINSatqslvkfVREEMGAYRLYTVVPYLVKFIDNLTniyvrfnrkrlkgRTGEEdCRTAL 770
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 118170488 849 EPL--VLMV-----APLAPHLAEELWKRL-----GHDTSLAHGPFPEADPQYLVED 892
Cdd:PLN02882 771 STLynVLLTsckvmAPFTPFFTEVLYQNLrkvlpGSEESIHYCSFPQVDEGELDER 826
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
807-889 |
1.13e-03 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 41.00 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118170488 807 LHRTIEGVREDYAALRNNTAAAKLIEYTNHLT------------KEGVAA--RAAIEPL--VL-----MVAPLAPHLAEE 865
Cdd:cd07961 56 LNSLIKEVTEEMEAYDLYTAVRALLEFIDELTnwyirrnrkrfwGEEGDDdkLAAYATLyeVLltlsrLMAPFTPFITEE 135
|
90 100
....*....|....*....|....*....
gi 118170488 866 LWKRLGHDTSLA----H-GPFPEADPQYL 889
Cdd:cd07961 136 IYQNLRRELGDApesvHlLDWPEVDESLI 164
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
851-896 |
3.45e-03 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 39.43 E-value: 3.45e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 118170488 851 LVLMVAPLAPHLAEELWKRLGHDT---SLAHGPFPEADPQYLVEDTIEF 896
Cdd:cd07960 120 LLKLLAPILPFTAEEVWEHLPGEKkeeSVFLEDWPELPEEWKDEELEEK 168
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
845-870 |
3.52e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 38.34 E-value: 3.52e-03
10 20
....*....|....*....|....*.
gi 118170488 845 RAAIEPLVLMVAPLAPHLAEELWKRL 870
Cdd:cd07959 92 RRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| |
