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Conserved domains on  [gi|81248068|gb|ABB68776|]
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conserved hypothetical protein [Shigella boydii Sb227]

Protein Classification

N-acetylneuraminate epimerase( domain architecture ID 11487115)

N-acetylneuraminate epimerase converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14131 PRK14131
N-acetylneuraminate epimerase;
40-404 0e+00

N-acetylneuraminate epimerase;


:

Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 584.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   40 TITALAIMMA---SFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATS 116
Cdd:PRK14131   1 TLTTLALLLAaasSFAANAEQLPDLPVPFKNGTGAIDNNTVYVGLGSAGTSWYKLDLNAPSKGWTKIAAFPGGPREQAVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  117 AFIDGNLYVFGGIGK-NREGLTQVFNDVHKYNPKTNSWVKLMSHAPMGMAGHVTFV-HNGKAYVTGGVNQNIFNGYFEDL 194
Cdd:PRK14131  81 AFIDGKLYVFGGIGKtNSEGSPQVFDDVYKYDPKTNSWQKLDTRSPVGLAGHVAVSlHNGKAYITGGVNKNIFDGYFEDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  195 NEAGKDSTAVDKINAYYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAV 274
Cdd:PRK14131 161 AAAGKDKTPKDKINDAYFDKKPEDYFFNKEVLSYDPSTNQWKNAGESPFLGTAGSAVVIKGNKLWLINGEIKPGLRTDAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  275 FELDFTGNNLKWNKLAPV------SSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQHGKNYAHEGLKKSYSTDIHLWH 348
Cdd:PRK14131 241 KQGKFTGNNLKWQKLPDLppapggSSQEGVAGAFAGYSNGVLLVAGGANFPGARENYQNGKLYAHEGLKKSWSDEIYALV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 81248068  349 NGKWDKSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVKDNKVTVQN 404
Cdd:PRK14131 321 NGKWQKVGELPQGLAYGVSVSWNNGVLLIGGETAGGKAVSDVTLLSWDGKKLTVEN 376
 
Name Accession Description Interval E-value
PRK14131 PRK14131
N-acetylneuraminate epimerase;
40-404 0e+00

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 584.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   40 TITALAIMMA---SFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATS 116
Cdd:PRK14131   1 TLTTLALLLAaasSFAANAEQLPDLPVPFKNGTGAIDNNTVYVGLGSAGTSWYKLDLNAPSKGWTKIAAFPGGPREQAVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  117 AFIDGNLYVFGGIGK-NREGLTQVFNDVHKYNPKTNSWVKLMSHAPMGMAGHVTFV-HNGKAYVTGGVNQNIFNGYFEDL 194
Cdd:PRK14131  81 AFIDGKLYVFGGIGKtNSEGSPQVFDDVYKYDPKTNSWQKLDTRSPVGLAGHVAVSlHNGKAYITGGVNKNIFDGYFEDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  195 NEAGKDSTAVDKINAYYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAV 274
Cdd:PRK14131 161 AAAGKDKTPKDKINDAYFDKKPEDYFFNKEVLSYDPSTNQWKNAGESPFLGTAGSAVVIKGNKLWLINGEIKPGLRTDAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  275 FELDFTGNNLKWNKLAPV------SSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQHGKNYAHEGLKKSYSTDIHLWH 348
Cdd:PRK14131 241 KQGKFTGNNLKWQKLPDLppapggSSQEGVAGAFAGYSNGVLLVAGGANFPGARENYQNGKLYAHEGLKKSWSDEIYALV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 81248068  349 NGKWDKSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVKDNKVTVQN 404
Cdd:PRK14131 321 NGKWQKVGELPQGLAYGVSVSWNNGVLLIGGETAGGKAVSDVTLLSWDGKKLTVEN 376
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 58-396 0e+00

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 531.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068    58 LPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIGK-NREGL 136
Cdd:TIGR03547   1 LPDLPVGFKNGTGAIIGDKVYVGLGSAGTSWYKLDLKKPSKGWQKIADFPGGPRNQAVAAAIDGKLYVFGGIGKaNSEGS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   137 TQVFNDVHKYNPKTNSWVKLMSHAPMGMAGHVTF-VHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTAVDKINAYYFDKK 215
Cdd:TIGR03547  81 PQVFDDVYRYDPKKNSWQKLDTRSPVGLLGASGFsLHNGQAYFTGGVNKNIFDGYFADLSAADKDSEPKDKLIAAYFSQP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   216 AEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFELDFTGNNLKWNKLAPV--- 292
Cdd:TIGR03547 161 PEDYFWNKNVLSYDPSTNQWRNLGENPFLGTAGSAIVHKGNKLLLINGEIKPGLRTAEVKQYLFTGGKLEWNKLPPLppp 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   293 --SSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQHGKNYAHEGLKKSYSTDIHLWHNGKWDKSGELSQGRAYGVSLPW 370
Cdd:TIGR03547 241 ksSSQEGLAGAFAGISNGVLLVAGGANFPGAQENYKNGKLYAHEGLIKAWSSEVYALDNGKWSKVGKLPQGLAYGVSVSW 320

                         330       340
                  ....*....|....*....|....*.
gi 81248068   371 NNSLLIIGGETAGGKAVTDSVLISVK 396
Cdd:TIGR03547 321 NNGVLLIGGENSGGKAVTDVYLLSWD 346
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
53-395 4.61e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 162.25  E-value: 4.61e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  53 ANASVLPETPVPFKSGTGAIDNDTVYIGLG----SAGTAWYKLDTqaKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGG 128
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGlsggSASNSFEVYDP--ATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068 129 IGKNrEGLTQVFNDVHKYNPKTNSWVKLMShAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDlneagkdstavdkin 208
Cdd:COG3055  79 FTGA-NPSSTPLNDVYVYDPATNTWTKLAP-MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEV--------------- 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068 209 ayyfdkkaedyffnkfllsFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEakpglrtdavfelDFTGNNLKWNK 288
Cdd:COG3055 142 -------------------YDPATGTWTQLAPLPTPRDHLAAAVLPDGKILVIGGR-------------NGSGFSNTWTT 189

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068 289 LAPvsSPDGVAGGFAGISNDSLIFAGGagfkgsrENYQHGKNYAheglkksYSTDihlwhNGKWDKSGELSQGRAYGVSL 368
Cdd:COG3055 190 LAP--LPTARAGHAAAVLGGKILVFGG-------ESGFSDEVEA-------YDPA-----TNTWTALGELPTPRHGHAAV 248

                       330       340
                ....*....|....*....|....*..
gi 81248068 369 PWNNSLLIIGGETAGGKAVTDSVLISV 395
Cdd:COG3055 249 LTDGKVYVIGGETKPGVRTPLVTSAEV 275
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 110-158 1.22e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.91  E-value: 1.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 81248068   110 PRDQATSAFIDGNLYVFGGIGKNregltQVFNDVHKYNPKTNSWVKLMS 158
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN-----QSLNSVEVYDPETNTWSKLPS 44
Kelch smart00612
Kelch domain;
123-169 4.51e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.84  E-value: 4.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 81248068    123 LYVFGGIgkNReglTQVFNDVHKYNPKTNSWVKL--MSHAPMGMAGHVT 169
Cdd:smart00612   2 IYVVGGF--DG---GQRLKSVEVYDPETNKWTPLpsMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
PRK14131 PRK14131
N-acetylneuraminate epimerase;
40-404 0e+00

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 584.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   40 TITALAIMMA---SFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATS 116
Cdd:PRK14131   1 TLTTLALLLAaasSFAANAEQLPDLPVPFKNGTGAIDNNTVYVGLGSAGTSWYKLDLNAPSKGWTKIAAFPGGPREQAVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  117 AFIDGNLYVFGGIGK-NREGLTQVFNDVHKYNPKTNSWVKLMSHAPMGMAGHVTFV-HNGKAYVTGGVNQNIFNGYFEDL 194
Cdd:PRK14131  81 AFIDGKLYVFGGIGKtNSEGSPQVFDDVYKYDPKTNSWQKLDTRSPVGLAGHVAVSlHNGKAYITGGVNKNIFDGYFEDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  195 NEAGKDSTAVDKINAYYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAV 274
Cdd:PRK14131 161 AAAGKDKTPKDKINDAYFDKKPEDYFFNKEVLSYDPSTNQWKNAGESPFLGTAGSAVVIKGNKLWLINGEIKPGLRTDAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  275 FELDFTGNNLKWNKLAPV------SSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQHGKNYAHEGLKKSYSTDIHLWH 348
Cdd:PRK14131 241 KQGKFTGNNLKWQKLPDLppapggSSQEGVAGAFAGYSNGVLLVAGGANFPGARENYQNGKLYAHEGLKKSWSDEIYALV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 81248068  349 NGKWDKSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVKDNKVTVQN 404
Cdd:PRK14131 321 NGKWQKVGELPQGLAYGVSVSWNNGVLLIGGETAGGKAVSDVTLLSWDGKKLTVEN 376
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 58-396 0e+00

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 531.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068    58 LPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIGK-NREGL 136
Cdd:TIGR03547   1 LPDLPVGFKNGTGAIIGDKVYVGLGSAGTSWYKLDLKKPSKGWQKIADFPGGPRNQAVAAAIDGKLYVFGGIGKaNSEGS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   137 TQVFNDVHKYNPKTNSWVKLMSHAPMGMAGHVTF-VHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTAVDKINAYYFDKK 215
Cdd:TIGR03547  81 PQVFDDVYRYDPKKNSWQKLDTRSPVGLLGASGFsLHNGQAYFTGGVNKNIFDGYFADLSAADKDSEPKDKLIAAYFSQP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   216 AEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFELDFTGNNLKWNKLAPV--- 292
Cdd:TIGR03547 161 PEDYFWNKNVLSYDPSTNQWRNLGENPFLGTAGSAIVHKGNKLLLINGEIKPGLRTAEVKQYLFTGGKLEWNKLPPLppp 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   293 --SSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQHGKNYAHEGLKKSYSTDIHLWHNGKWDKSGELSQGRAYGVSLPW 370
Cdd:TIGR03547 241 ksSSQEGLAGAFAGISNGVLLVAGGANFPGAQENYKNGKLYAHEGLIKAWSSEVYALDNGKWSKVGKLPQGLAYGVSVSW 320

                         330       340
                  ....*....|....*....|....*.
gi 81248068   371 NNSLLIIGGETAGGKAVTDSVLISVK 396
Cdd:TIGR03547 321 NNGVLLIGGENSGGKAVTDVYLLSWD 346
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
53-395 4.61e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 162.25  E-value: 4.61e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  53 ANASVLPETPVPFKSGTGAIDNDTVYIGLG----SAGTAWYKLDTqaKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGG 128
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGlsggSASNSFEVYDP--ATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068 129 IGKNrEGLTQVFNDVHKYNPKTNSWVKLMShAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDlneagkdstavdkin 208
Cdd:COG3055  79 FTGA-NPSSTPLNDVYVYDPATNTWTKLAP-MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEV--------------- 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068 209 ayyfdkkaedyffnkfllsFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEakpglrtdavfelDFTGNNLKWNK 288
Cdd:COG3055 142 -------------------YDPATGTWTQLAPLPTPRDHLAAAVLPDGKILVIGGR-------------NGSGFSNTWTT 189

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068 289 LAPvsSPDGVAGGFAGISNDSLIFAGGagfkgsrENYQHGKNYAheglkksYSTDihlwhNGKWDKSGELSQGRAYGVSL 368
Cdd:COG3055 190 LAP--LPTARAGHAAAVLGGKILVFGG-------ESGFSDEVEA-------YDPA-----TNTWTALGELPTPRHGHAAV 248

                       330       340
                ....*....|....*....|....*..
gi 81248068 369 PWNNSLLIIGGETAGGKAVTDSVLISV 395
Cdd:COG3055 249 LTDGKVYVIGGETKPGVRTPLVTSAEV 275
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 58-275 4.38e-33

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 126.44  E-value: 4.38e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068    58 LPETPVPFKSGTGAIDNDTVYIGLG----SAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIgkNR 133
Cdd:TIGR03548 108 LPSLPVAFDNGSATYKDGKIYVGGGnangKPSNKFYCLDLSNDTSGWEELPEFPGEARVQPVCQALHGKLYVFGGF--QL 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   134 EGLTQVFNDVHKYNPKTNSWVK-----LMSHAPMGMAGHVTFVHN-GKAYVTGGVNQNIFNGYFEDLNEAGKDSTAVDKi 207
Cdd:TIGR03548 186 GGDAIIYTDGYAYSPKTNTWQTvadpvLSDGEPITLLGGNSVKLGdSLMLVIGGVNYDIFFDAVDRLRQMKDESLKSEK- 264

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81248068   208 nAYYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVF 275
Cdd:TIGR03548 265 -AEYFGHPPQWYRFNDKVLIYNVRSNEWKSIGAVPFVARAGAALLLHGDNIFSINGEIKPGIRTPRIY 331
PHA03098 PHA03098
kelch-like protein; Provisional
 58-183 7.51e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 60.55  E-value: 7.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   58 LPETPVPFKSGTGAIDNDTVYI--GLGSAGTAWYKLDTQAKDKKWTALAAFPGgPRDQATSAFIDGNLYVFGGIGKNREG 135
Cdd:PHA03098 326 VPELIYPRKNPGVTVFNNRIYVigGIYNSISLNTVESWKPGESKWREEPPLIF-PRYNPCVVNVNNLIYVIGGISKNDEL 404

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 81248068  136 LtqvfNDVHKYNPKTNSWvKLMSHAPMGMAGHVTFVHNGKAYVTGGVN 183
Cdd:PHA03098 405 L----KTVECFSLNTNKW-SKGSPLPISHYGGCAIYHDGKIYVIGGIS 447
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 110-158 1.22e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.91  E-value: 1.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 81248068   110 PRDQATSAFIDGNLYVFGGIGKNregltQVFNDVHKYNPKTNSWVKLMS 158
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN-----QSLNSVEVYDPETNTWSKLPS 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
110-156 2.14e-06

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 44.14  E-value: 2.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 81248068   110 PRDQATSAFI-DGNLYVFGGIGKNreglTQVFNDVHKYNPKTNSWVKL 156
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGED----GTLLSDLWVFDLSTNEWTRL 44
Kelch_6 pfam13964
Kelch motif;
110-156 4.21e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.48  E-value: 4.21e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 81248068   110 PRDQATSAFIDGNLYVFGGigknREGLTQVFNDVHKYNPKTNSWVKL 156
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEEL 43
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 110-156 6.80e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 42.71  E-value: 6.80e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 81248068   110 PRDQATSAFIDGNLYVFGGIGKNREgltQVFNDVHKYNPKTNSWVKL 156
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGD---LSSSDVLVYDPETNVWTEV 44
PHA03098 PHA03098
kelch-like protein; Provisional
 78-316 1.81e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   78 YIGLGSAGTAWYKLDTQAKDKKWTALAAFPGgpRDQATSAFIDGNLYVFGGIGKNREgltqVFNDVHKYNPKTNSWVKL- 156
Cdd:PHA03098 254 YIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMNKNNL----SVNSVVSYDTKTKSWNKVp 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  157 -MSHAPMGMAghvTFVHNGKAYVTGGVNQNIFNGYFE-------------DLNEAGKDSTAVDKINAYY-FDKKAEDYFF 221
Cdd:PHA03098 328 eLIYPRKNPG---VTVFNNRIYVIGGIYNSISLNTVEswkpgeskwreepPLIFPRYNPCVVNVNNLIYvIGGISKNDEL 404

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068  222 NKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGdKTWLINGEAKPGLRTDAVFELDFTGNNLKWNKLAPVSSPDGVAgg 301
Cdd:PHA03098 405 LKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDG-KIYVIGGISYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINA-- 481

                        250
                 ....*....|....*
gi 81248068  302 FAGISNDSLIFAGGA 316
Cdd:PHA03098 482 SLCIFNNKIYVVGGD 496
PHA03098 PHA03098
kelch-like protein; Provisional
 71-220 2.85e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 42.83  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81248068   71 AIDNDTVYIgLGSAGTAWYKLDT----QAKDKKWTALAAFPGgPRDQATSAFIDGNLYVFGGIgkNREGLTQVFNDVHKY 146
Cdd:PHA03098 386 VNVNNLIYV-IGGISKNDELLKTvecfSLNTNKWSKGSPLPI-SHYGGCAIYHDGKIYVIGGI--SYIDNIKVYNIVESY 461

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81248068  147 NPKTNSWVKL-MSHAPMGMAGhVTFVHNgKAYVTGGVNQNIFNGYFEDLNEAGKDSTAVDKINAYYFDKKAEDYF 220
Cdd:PHA03098 462 NPVTNKWTELsSLNFPRINAS-LCIFNN-KIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGSLEKNIFT 534
Kelch_3 pfam13415
Galactose oxidase, central domain;
120-167 7.70e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.27  E-value: 7.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 81248068   120 DGNLYVFGGIGKNREGLTqvfNDVHKYNPKTNSWVKLMShAPMGMAGH 167
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRL---NDLYVYDLDTNTWTQIGD-LPPPRSGH 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 110-151 2.30e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 35.62  E-value: 2.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 81248068   110 PRDQATSAFIDGNLYVFGGIGKNReglTQVFNDVHKYNPKTN 151
Cdd:pfam13854   3 PRYGHCAVTVGDYIYLYGGYTGGE---GQPSDDVYVLSLPTF 41
Kelch smart00612
Kelch domain;
123-169 4.51e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.84  E-value: 4.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 81248068    123 LYVFGGIgkNReglTQVFNDVHKYNPKTNSWVKL--MSHAPMGMAGHVT 169
Cdd:smart00612   2 IYVVGGF--DG---GQRLKSVEVYDPETNKWTPLpsMPTPRSGHGVAVI 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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