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Conserved domains on  [gi|68304453|gb|AAY89802|]
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beta-tubulin, partial [Mycosphaerella populi]

Protein Classification

tubulin beta chain( domain architecture ID 10115118)

tubulin beta chain is part of tubulin, a dimer of alpha and beta chains, which is the major constituent of microtubules and binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
1-281 0e+00

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


:

Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 560.65  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:cd02187 116 LDVVRKEAESCDCLQGFQLTHSLGGGTGSGLGTLLLSKLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENA 195
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:cd02187 196 DETFCIDNEALYNICQRTLKLTQPTYDDLNHLISQVMSGITSSLRFPGQLNSDLRKLATNLVPFPRLHFLTPGFAPLTSR 275
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSI 240
Cdd:cd02187 276 GSQQYRKLTVPELTQQLFDAKNMMAACDPRHGRYLTAAAIFRGRISTKEVDEQMSKVQNKNSSYFVEWIPNNVKTSVCDI 355
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68304453 241 PPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:cd02187 356 PPRGLKMSATFIGNSTAIQELFKRLSEQFTAMFRRKAFLHW 396
 
Name Accession Description Interval E-value
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
1-281 0e+00

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 560.65  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:cd02187 116 LDVVRKEAESCDCLQGFQLTHSLGGGTGSGLGTLLLSKLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENA 195
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:cd02187 196 DETFCIDNEALYNICQRTLKLTQPTYDDLNHLISQVMSGITSSLRFPGQLNSDLRKLATNLVPFPRLHFLTPGFAPLTSR 275
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSI 240
Cdd:cd02187 276 GSQQYRKLTVPELTQQLFDAKNMMAACDPRHGRYLTAAAIFRGRISTKEVDEQMSKVQNKNSSYFVEWIPNNVKTSVCDI 355
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68304453 241 PPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:cd02187 356 PPRGLKMSATFIGNSTAIQELFKRLSEQFTAMFRRKAFLHW 396
PLN00220 PLN00220
tubulin beta chain; Provisional
1-281 0e+00

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 558.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453    1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:PLN00220 117 LDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENA 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:PLN00220 197 DECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSR 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSI 240
Cdd:PLN00220 277 GSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDI 356
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 68304453  241 PPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:PLN00220 357 PPKGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHW 397
Tubulin_C pfam03953
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ...
145-265 6.74e-59

Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).


Pssm-ID: 397858 [Multi-domain]  Cd Length: 125  Bit Score: 183.59  E-value: 6.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   145 PRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAY 224
Cdd:pfam03953   1 PRLHFLLTSYAPLTSANKASHEKTSVLDVTRRLFDPKNQMVSCDPRNGKYMACALLYRGDVSPKDVHRAIQRIKEKRSAQ 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 68304453   225 FVEWIPNNVQTALCSIPPRGLKMSS---TFVGNSTSIQELFKRV 265
Cdd:pfam03953  81 FVEWCPTGIKVAICSQSPYVVPGSKvsgLMLANTTSIAELFQRL 124
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
1-128 2.12e-35

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 125.68  E-value: 2.12e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453      1 LDVVRREAEGCDclqGFQITHSLgggtgagmgtlLISKIREEFPDRMMAtFSVMPspKVSDTVVEPYNATLSVHQLVENS 80
Cdd:smart00864  73 LDEIREELEGAD---GVFITAGMgggtg-tgaapVIAEIAKEYGILTVA-VVTKP--FSFEGVVRPYNAELGLEELREHV 145
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 68304453     81 DETFCIDNEALYDICMRTLKLnNPSYGDLNHLVSAVMSGVTTCLRFPG 128
Cdd:smart00864 146 DSLIVIDNDALLDICGRKLPL-RPAFKDANDLLAQAVSGITDLIRFPG 192
 
Name Accession Description Interval E-value
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
1-281 0e+00

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 560.65  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:cd02187 116 LDVVRKEAESCDCLQGFQLTHSLGGGTGSGLGTLLLSKLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENA 195
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:cd02187 196 DETFCIDNEALYNICQRTLKLTQPTYDDLNHLISQVMSGITSSLRFPGQLNSDLRKLATNLVPFPRLHFLTPGFAPLTSR 275
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSI 240
Cdd:cd02187 276 GSQQYRKLTVPELTQQLFDAKNMMAACDPRHGRYLTAAAIFRGRISTKEVDEQMSKVQNKNSSYFVEWIPNNVKTSVCDI 355
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68304453 241 PPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:cd02187 356 PPRGLKMSATFIGNSTAIQELFKRLSEQFTAMFRRKAFLHW 396
PLN00220 PLN00220
tubulin beta chain; Provisional
1-281 0e+00

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 558.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453    1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:PLN00220 117 LDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENA 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:PLN00220 197 DECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSR 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSI 240
Cdd:PLN00220 277 GSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDI 356
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 68304453  241 PPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:PLN00220 357 PPKGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHW 397
PTZ00010 PTZ00010
tubulin beta chain; Provisional
1-281 0e+00

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 553.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453    1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:PTZ00010 117 LDVVRKEAESCDCLQGFQITHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENA 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:PTZ00010 197 DESMCIDNEALYDICFRTLKLTTPTYGDLNHLVSAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSR 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSI 240
Cdd:PTZ00010 277 GSQQYRGLSVPELTQQMFDAKNMMCAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSVCDI 356
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 68304453  241 PPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:PTZ00010 357 PPKGLKMSVTFIGNSTAIQEMFRRVGEQFTAMFRRKAFLHW 397
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
1-281 1.47e-106

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 314.53  E-value: 1.47e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:cd06059  78 LDRIRKQVEKCDSLQGFFILHSLGGGTGSGLGSYLLELLEDEYPKVYRFTFSVFPSPDDDNVITSPYNSVLALNHLTEHA 157
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  81 DETFCIDNEALYDICMR---TLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPL 157
Cdd:cd06059 158 DCVLPIDNEALYDICNRqpaTLDIDFPPFDDMNNLVAQLLSSLTSSLRFEGSLNVDLNEITTNLVPFPRLHFLLPSLSPL 237
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 158 TSRGAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKV-SMKEVEDQIRNVQNKNTayFVEWIPNNVQTA 236
Cdd:cd06059 238 TSANDVTLEPLTLDQLFSDLFSKDNQLVGCDPRHGTYLACALLLRGKVfSLSDVRRNIDRIKPKLK--FISWNPDGFKVG 315
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68304453 237 LCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:cd06059 316 LCSVPPVGQKYSLLFLSNNTSIASTFERLIERFDKLYKRKAFLHH 360
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
1-281 1.10e-104

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 311.39  E-value: 1.10e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:cd02186 118 LDRIRKLAEQCDGLQGFLIFHSVGGGTGSGLTSLLLERLSVDYGKKSKLEFSIYPSPQVSTSVVEPYNSVLTTHSLLEHS 197
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:cd02186 198 DCSILLDNEALYDICRRQLDIERPTYTNLNRLIAQVVSSLTASLRFDGALNVDLNEFQTNLVPYPRIHFPLVSYAPIISA 277
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSI 240
Cdd:cd02186 278 EKANHEQLSVQEITNSCFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQ 357
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68304453 241 PP---RGLKMSSTF-----VGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:cd02186 358 PPtvvPGSDLAKVDrsvcmLANSTAIAEAFQRLDHKFDLLYSKRAFVHW 406
Tubulin_FtsZ_Cetz-like cd00286
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
1-255 3.53e-94

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


Pssm-ID: 276954 [Multi-domain]  Cd Length: 332  Bit Score: 280.83  E-value: 3.53e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSdTVVEPYNATLSVHQLVENS 80
Cdd:cd00286  78 LDAIRKEVEECDELQGFFITHSLGGGTGSGLGPLLAERLKDEYPNRLVVTFSILPGPDEG-VIVYPYNAALTLKTLTEHA 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:cd00286 157 DCLLLVDNEALYDICPRPLHIDAPAYDHINELVAQRLGSLTEALRFEGSLNVDLRELAENLVPLPRGHFLMLGYAPLDSA 236
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKV--SMKEVEDQIRNVQNKNTAYFvEWIPNNVQTALC 238
Cdd:cd00286 237 TSATPRSLRVKELTRRAFLPANLLVGCDPDHGEAIAALLVIRGPPdlSSKEVERAIARVKETLGHLF-SWSPAGVKTGIS 315
                       250
                ....*....|....*..
gi 68304453 239 SIPPRGLKMSSTFVGNS 255
Cdd:cd00286 316 PKPPAEGEVSVLALLNS 332
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
1-281 1.61e-86

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 265.42  E-value: 1.61e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453    1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:PTZ00335 119 LDRIRKLADNCTGLQGFLVFHAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHT 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:PTZ00335 199 DVAVMLDNEAIYDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDLTEFQTNLVPYPRIHFMLSSYAPIISA 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTAL--- 237
Cdd:PTZ00335 279 EKAYHEQLSVAEITNSAFEPANMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGInyq 358
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 68304453  238 --CSIPPRGL---KMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:PTZ00335 359 ppTVVPGGDLakvQRAVCMISNSTAIAEVFSRIDHKFDLMYAKRAFVHW 407
PLN00221 PLN00221
tubulin alpha chain; Provisional
1-281 1.60e-80

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 250.11  E-value: 1.60e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453    1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENS 80
Cdd:PLN00221 119 LDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHT 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   81 DETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSR 160
Cdd:PLN00221 199 DVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQVISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYAPVISA 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  161 GAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSI 240
Cdd:PLN00221 279 EKAYHEQLSVAEITNSAFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQ 358
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 68304453  241 PPR--------GLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:PLN00221 359 PPTvvpggdlaKVQRAVCMISNSTAVAEVFSRIDHKFDLMYAKRAFVHW 407
gamma_tubulin cd02188
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ...
1-279 6.41e-78

The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.


Pssm-ID: 276957 [Multi-domain]  Cd Length: 430  Bit Score: 242.45  E-value: 6.41e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPK-VSDTVVEPYNATLSVHQLVEN 79
Cdd:cd02188 117 LDIIDREAEGSDSLEGFVLCHSIAGGTGSGMGSYLLERLSDRYPKKLIQTYSVFPNQEeSSDVVVQPYNSILTLKRLTLN 196
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  80 SDETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTS 159
Cdd:cd02188 197 ADCVVVLDNTALNRIATDRLKIDNPSFSQINSLISTVMSASTSTLRFPGYMNNDLVSLISSLIPTPRLHFLMTSYTPLTS 276
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 160 -RGAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALC 238
Cdd:cd02188 277 dQVASSVRKTTVLDVMRRLLQPKNRMVSTSTKNGCYISILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALS 356
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68304453 239 SIPPRgLKMSSTFVG----NSTSIQELFKRVGDQFTAMFKRKAFL 279
Cdd:cd02188 357 KKSPY-VQTAHRVSGlmlaNHTSISSLFEKILSQYDKLRKRNAFL 400
PLN00222 PLN00222
tubulin gamma chain; Provisional
1-279 1.93e-65

tubulin gamma chain; Provisional


Pssm-ID: 215108 [Multi-domain]  Cd Length: 454  Bit Score: 211.24  E-value: 1.93e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453    1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPS-PKVSDTVVEPYNATLSVHQLVEN 79
Cdd:PLN00222 119 MDMIDREADGSDSLEGFVLCHSIAGGTGSGMGSYLLEALNDRYSKKLVQTYSVFPNqMETSDVVVQPYNSLLTLKRLTLN 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   80 SDETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPL-T 158
Cdd:PLN00222 199 ADCVVVLDNTALNRIAVDRLHLENPTFAQTNSLVSTVMSASTTTLRYPGYMNNDLVGLLASLIPTPRCHFLMTGYTPLtV 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  159 SRGAHSFRAVTVPELTQQIFDPKNMMAASDFRN-----GRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNV 233
Cdd:PLN00222 279 ERQANVIRKTTVLDVMRRLLQTKNIMVSSYARTkeasqAKYISILNIIQGEVDPTQVHKSLQRIRERKLANFIEWGPASI 358
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 68304453  234 QTALCSIPP---RGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFL 279
Cdd:PLN00222 359 QVALSRKSPyvqTAHRVSGLMLANHTSIRHLFSKCLSQYDKLRKKQAFL 407
Tubulin_C pfam03953
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ...
145-265 6.74e-59

Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).


Pssm-ID: 397858 [Multi-domain]  Cd Length: 125  Bit Score: 183.59  E-value: 6.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   145 PRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAY 224
Cdd:pfam03953   1 PRLHFLLTSYAPLTSANKASHEKTSVLDVTRRLFDPKNQMVSCDPRNGKYMACALLYRGDVSPKDVHRAIQRIKEKRSAQ 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 68304453   225 FVEWIPNNVQTALCSIPPRGLKMSS---TFVGNSTSIQELFKRV 265
Cdd:pfam03953  81 FVEWCPTGIKVAICSQSPYVVPGSKvsgLMLANTTSIAELFQRL 124
PTZ00387 PTZ00387
epsilon tubulin; Provisional
2-280 1.08e-56

epsilon tubulin; Provisional


Pssm-ID: 240395 [Multi-domain]  Cd Length: 465  Bit Score: 188.78  E-value: 1.08e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453    2 DVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSpKVSDTVVEPYNATLSVHQLVENSD 81
Cdd:PTZ00387 119 ESVRRQVEQCDSLQSFFLMHSLGGGTGSGLGTRILGMLEDEFPHVFRFCPVVFPS-AVDDVITSPYNSFFALRELIEHAD 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   82 ETFCIDNEALYDICMRTLKLN----------------------------NPsYGDLNHLVSAVMSGVTTCLRFPGQLNSD 133
Cdd:PTZ00387 198 CVLPLDNDALANIADSALSRKkkklakgnikrgpqphkysvakptetkkLP-YDKMNNIVAQLLSNLTSSMRFEGSLNVD 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  134 LRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEdq 213
Cdd:PTZ00387 277 INEITTNLVPYPRLHFLTSSIAPLVSLKDVAVGPRRLDQMFKDCLDPDHQMVAATPEAGKYLATALIVRGPQNVSDVT-- 354
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68304453  214 iRNVQN-KNTAYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLH 280
Cdd:PTZ00387 355 -RNILRlKEQLNMIYWNEDGFKTGLCNVSPLGQPYSLLCLANNCCIRNKFESMLERFNKLYKRKSHVH 421
epsilon_tubulin cd02190
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ...
1-280 2.26e-56

The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.


Pssm-ID: 276959 [Multi-domain]  Cd Length: 449  Bit Score: 187.45  E-value: 2.26e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSpKVSDTVVEPYNATLSVHQLVENS 80
Cdd:cd02190 123 LEKLRRAAEKCDSLQSFFLLHSLGGGTGSGLGSYILELLEDEFPDVYRFVTSVFPS-GDDDVITSPYNSVLALRELTEHA 201
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  81 DETFCIDNEALYDICMRTLKLNNP----------------------SYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLA 138
Cdd:cd02190 202 DCVLPVENQALMDIVNKIKSSKDKgktgvlaainssgggqkkgkkkPFDDMNNIVANLLLNLTSSMRFEGSLNVDLNEIT 281
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 139 VNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVsmkEVEDQIRNVQ 218
Cdd:cd02190 282 TNLVPFPRLHFLLSSLSPLYALADVRLPPRRLDQMFSDAFSRDHQLLKADPKHGLYLACALLVRGNV---SISDLRRNID 358
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68304453 219 N-KNTAYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLH 280
Cdd:cd02190 359 RlKRQLKFVSWNQDGWKIGLCSVPPVGQPYSLLCLANNTCIKPTFTEMHERFDKLYKRKAHLH 421
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
1-128 2.12e-35

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 125.68  E-value: 2.12e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453      1 LDVVRREAEGCDclqGFQITHSLgggtgagmgtlLISKIREEFPDRMMAtFSVMPspKVSDTVVEPYNATLSVHQLVENS 80
Cdd:smart00864  73 LDEIREELEGAD---GVFITAGMgggtg-tgaapVIAEIAKEYGILTVA-VVTKP--FSFEGVVRPYNAELGLEELREHV 145
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 68304453     81 DETFCIDNEALYDICMRTLKLnNPSYGDLNHLVSAVMSGVTTCLRFPG 128
Cdd:smart00864 146 DSLIVIDNDALLDICGRKLPL-RPAFKDANDLLAQAVSGITDLIRFPG 192
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
1-281 2.30e-31

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 120.45  E-value: 2.30e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453   1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSpKVSDTVVEPYNATLSVHQLVENS 80
Cdd:cd02189 111 LEALRREAERCDRLSGFLVLHSLAGGTGSGLGSRVTELLRDEYPKAYLLNTVVWPY-SSGEVPVQNYNTLLTLSHLQESS 189
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453  81 DETFCIDNEALYDICMRTLKLNNP-SYGDLNHLVSAVMSGV---TTCLRFPGQLNSD-LRKLAVNMVPFPRLHFFMVGFA 155
Cdd:cd02189 190 DGILLFENDDLHKICSKLLGLKNPvSFSDINRVIARQLAGVllpSSSPTSPSPLRRCpLGDLLEHLCPHPAYKLLTLRSL 269
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453 156 PLTSRGAHSFRAVTVPELTQQI-------------FDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVqnKNT 222
Cdd:cd02189 270 PQMPEPSRAFSTYTWPSLLKRLrqmlitgakleegIDWQLLDTSGSHNPNKSLAALLVLRGKDAMKVHSADLSAF--KDP 347
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 68304453 223 AYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFKRKAFLHW 281
Cdd:cd02189 348 VLYSPWVPNPFNVSVSPRPFNGYEKSVTLLSNSQNIVGPLDSLLEKAWQMFKAGAYLHQ 406
Tubulin_C smart00865
Tubulin/FtsZ family, C-terminal domain; This domain is found in the tubulin alpha, beta and ...
130-267 2.10e-27

Tubulin/FtsZ family, C-terminal domain; This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


Pssm-ID: 214868 [Multi-domain]  Cd Length: 120  Bit Score: 102.63  E-value: 2.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453    130 LNSDLRKLAVNMVPFPrlhFFMVGFAPLTSRgahsFRAVTVPELTQ--QIFDPKNMMAASDFRNgrYLTCSAiyrgKVSM 207
Cdd:smart00865   1 INVDFADVKTVMVPMG---FAMMGIGPASGE----NRALEAAELAIssPLLEDSNIMGAKGVLV--NITGGP----DLTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68304453    208 KEVEDQIRNVQNKNT-AYFVEWIPNNVQTalcsipprgLKMSSTFVGN-STSIQELFKRVGD 267
Cdd:smart00865  68 KEVNEAMERIREKADpDAFIIWGPVIDEE---------LGGDEIRVTViATGIGSLFKRLSE 120
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
1-95 3.79e-26

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 101.53  E-value: 3.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68304453     1 LDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSpKVSDTVVEPYNATLSVHQLVENS 80
Cdd:pfam00091  96 LEEIRKEVEGCDMLQGFFITASLGGGTGSGAAPVIAEILKELYPGALTVAVVTFPF-GFSEGVVRPYNAILGLKELIEHS 174
                          90
                  ....*....|....*
gi 68304453    81 DETFCIDNEALYDIC 95
Cdd:pfam00091 175 DSVIVIDNDALYDIC 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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