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Conserved domains on  [gi|67867270|gb|AAY82529|]
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recombination activating protein 2, partial [Cornufer guentheri]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RAG2 super family cl28748
Recombination activating protein 2; V-D-J recombination is the combinatorial process by which ...
7-258 8.16e-165

Recombination activating protein 2; V-D-J recombination is the combinatorial process by which the huge range of immunoglobulin and T cell binding specificity is generated from a limited amount of genetic material. This process is synergistically activated by RAG1 and RAG2 in developing lymphocytes. Defects in RAG2 in humans are a cause of severe combined immunodeficiency B cell negative and Omenn syndrome.


The actual alignment was detected with superfamily member pfam03089:

Pssm-ID: 427128  Cd Length: 339  Bit Score: 459.59  E-value: 8.16e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270     7 KENELKLRPTTFTNDSCYLPPLRHPAVASLSDSSGGEVSQYFIHGGKTPNSELSQKLYVMSIVPSANKRAILCCLEKDLV 86
Cdd:pfam03089   1 KKNELKLRPASFSNDSCYLPPLRYPAICTLKPSDEGEKEQYLIHGGKTPNNELSDKLYIMSLDSKGNKKVTLRCTEKELV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270    87 GDIPEARYGHSMNIIHSRGKTAVVLFGGRAYIPLNQRITETWNSVIECQPLVYLIDLQFGCSTAYTIKEIQDGFSFHVSV 166
Cdd:pfam03089  81 GDVPEARYGHTISVVYSRGKSACVLFGGRSYMPPGQRTTENWNSVVDCPPQVFLIDLEFGCCTSYTLPELQDGQSFHVSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270   167 SRNDTVYIIGGHTLEKNIRSPNIYKIKVDLPLGSPALTCTVLQNGLSVSSAIVTYTCSDEFLIVGGYESDSQKRMTCNKV 246
Cdd:pfam03089 161 ARNDTVYILGGHSLANNSRPPRLYRLKVDLPLGSPAVSCTVLPGGISVSSAIVTQTGSHEFVIVGGYQSESQKRMVCNTV 240
                         250
                  ....*....|..
gi 67867270   247 SISNDDIDIQEV 258
Cdd:pfam03089 241 VLEDNKIEIEER 252
 
Name Accession Description Interval E-value
RAG2 pfam03089
Recombination activating protein 2; V-D-J recombination is the combinatorial process by which ...
7-258 8.16e-165

Recombination activating protein 2; V-D-J recombination is the combinatorial process by which the huge range of immunoglobulin and T cell binding specificity is generated from a limited amount of genetic material. This process is synergistically activated by RAG1 and RAG2 in developing lymphocytes. Defects in RAG2 in humans are a cause of severe combined immunodeficiency B cell negative and Omenn syndrome.


Pssm-ID: 427128  Cd Length: 339  Bit Score: 459.59  E-value: 8.16e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270     7 KENELKLRPTTFTNDSCYLPPLRHPAVASLSDSSGGEVSQYFIHGGKTPNSELSQKLYVMSIVPSANKRAILCCLEKDLV 86
Cdd:pfam03089   1 KKNELKLRPASFSNDSCYLPPLRYPAICTLKPSDEGEKEQYLIHGGKTPNNELSDKLYIMSLDSKGNKKVTLRCTEKELV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270    87 GDIPEARYGHSMNIIHSRGKTAVVLFGGRAYIPLNQRITETWNSVIECQPLVYLIDLQFGCSTAYTIKEIQDGFSFHVSV 166
Cdd:pfam03089  81 GDVPEARYGHTISVVYSRGKSACVLFGGRSYMPPGQRTTENWNSVVDCPPQVFLIDLEFGCCTSYTLPELQDGQSFHVSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270   167 SRNDTVYIIGGHTLEKNIRSPNIYKIKVDLPLGSPALTCTVLQNGLSVSSAIVTYTCSDEFLIVGGYESDSQKRMTCNKV 246
Cdd:pfam03089 161 ARNDTVYILGGHSLANNSRPPRLYRLKVDLPLGSPAVSCTVLPGGISVSSAIVTQTGSHEFVIVGGYQSESQKRMVCNTV 240
                         250
                  ....*....|..
gi 67867270   247 SISNDDIDIQEV 258
Cdd:pfam03089 241 VLEDNKIEIEER 252
 
Name Accession Description Interval E-value
RAG2 pfam03089
Recombination activating protein 2; V-D-J recombination is the combinatorial process by which ...
7-258 8.16e-165

Recombination activating protein 2; V-D-J recombination is the combinatorial process by which the huge range of immunoglobulin and T cell binding specificity is generated from a limited amount of genetic material. This process is synergistically activated by RAG1 and RAG2 in developing lymphocytes. Defects in RAG2 in humans are a cause of severe combined immunodeficiency B cell negative and Omenn syndrome.


Pssm-ID: 427128  Cd Length: 339  Bit Score: 459.59  E-value: 8.16e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270     7 KENELKLRPTTFTNDSCYLPPLRHPAVASLSDSSGGEVSQYFIHGGKTPNSELSQKLYVMSIVPSANKRAILCCLEKDLV 86
Cdd:pfam03089   1 KKNELKLRPASFSNDSCYLPPLRYPAICTLKPSDEGEKEQYLIHGGKTPNNELSDKLYIMSLDSKGNKKVTLRCTEKELV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270    87 GDIPEARYGHSMNIIHSRGKTAVVLFGGRAYIPLNQRITETWNSVIECQPLVYLIDLQFGCSTAYTIKEIQDGFSFHVSV 166
Cdd:pfam03089  81 GDVPEARYGHTISVVYSRGKSACVLFGGRSYMPPGQRTTENWNSVVDCPPQVFLIDLEFGCCTSYTLPELQDGQSFHVSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67867270   167 SRNDTVYIIGGHTLEKNIRSPNIYKIKVDLPLGSPALTCTVLQNGLSVSSAIVTYTCSDEFLIVGGYESDSQKRMTCNKV 246
Cdd:pfam03089 161 ARNDTVYILGGHSLANNSRPPRLYRLKVDLPLGSPAVSCTVLPGGISVSSAIVTQTGSHEFVIVGGYQSESQKRMVCNTV 240
                         250
                  ....*....|..
gi 67867270   247 SISNDDIDIQEV 258
Cdd:pfam03089 241 VLEDNKIEIEER 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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