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Conserved domains on  [gi|66932585|gb|AAY58199|]
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isocitrate dehydrogenase, partial [Collomia heterophylla]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
1-80 2.45e-62

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member PLN00103:

Pssm-ID: 444908  Cd Length: 410  Bit Score: 193.51  E-value: 2.45e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585    1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:PLN00103 275 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDGNARL 354
 
Name Accession Description Interval E-value
PLN00103 PLN00103
isocitrate dehydrogenase (NADP+); Provisional
 1-80 2.45e-62

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177720  Cd Length: 410  Bit Score: 193.51  E-value: 2.45e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585    1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:PLN00103 275 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDGNARL 354
nadp_idh_euk TIGR00127
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
 1-80 4.72e-55

isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]


Pssm-ID: 129233  Cd Length: 409  Bit Score: 174.68  E-value: 4.72e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585     1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:TIGR00127 272 DGDVQSDIVAQGFGSLGLMTSVLICPDGKTFEAEAAHGTVTRHYRMYQKGQETSTNSIASIFAWSRGLAHRAKLDNNPEL 351
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 1-76 7.07e-33

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 116.36  E-value: 7.07e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932585   1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKtIEAEAAHGTVTRHfrvhqkGGETSTNSIASIFAWSRGLAHRAKLDN 76
Cdd:COG0538 295 NGDYISDALAAQVGGLGIAPGANIGDDGG-AEFEATHGTAPKY------AGKDSTNPGSLILSGTMMLRHRGWLEA 363
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
1-80 8.20e-23

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 88.89  E-value: 8.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585     1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGkTIEAEAAHGTVTRHFRVHQkggetsTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:pfam00180 240 FGDILSDEASMLTGSLGLLPSASLGANG-FGIFEPVHGSAPDIAGKGI------ANPIATILSAAMMLRYSLGLEDAADK 312
 
Name Accession Description Interval E-value
PLN00103 PLN00103
isocitrate dehydrogenase (NADP+); Provisional
 1-80 2.45e-62

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177720  Cd Length: 410  Bit Score: 193.51  E-value: 2.45e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585    1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:PLN00103 275 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDGNARL 354
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 1-80 1.02e-61

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 191.74  E-value: 1.02e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585    1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:PTZ00435 274 DGDVQSDIVAQGYGSLGLMTSVLVCPDGKTVEAEAAHGTVTRHYRQHQKGKETSTNSIASIFAWTRGLAHRAKLDNNQEL 353
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
1-80 7.04e-58

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 181.59  E-value: 7.04e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585    1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:PRK08299 271 DGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKGEETSTNPIASIFAWTRGLAHRGKLDGNPEL 350
nadp_idh_euk TIGR00127
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
 1-80 4.72e-55

isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]


Pssm-ID: 129233  Cd Length: 409  Bit Score: 174.68  E-value: 4.72e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585     1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:TIGR00127 272 DGDVQSDIVAQGFGSLGLMTSVLICPDGKTFEAEAAHGTVTRHYRMYQKGQETSTNSIASIFAWSRGLAHRAKLDNNPEL 351
PLN03065 PLN03065
isocitrate dehydrogenase (NADP+); Provisional
 1-80 1.21e-53

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 178617 [Multi-domain]  Cd Length: 483  Bit Score: 172.76  E-value: 1.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585    1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:PLN03065 342 DGDVQSDLLAQGFGSLGLMTSVLLSSDGKTLEAEAAHGTVTRHFRLHQKGQETSTNSIASIFAWTRGLEHRAKLDKNEEL 421
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 1-76 7.07e-33

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 116.36  E-value: 7.07e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932585   1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKtIEAEAAHGTVTRHfrvhqkGGETSTNSIASIFAWSRGLAHRAKLDN 76
Cdd:COG0538 295 NGDYISDALAAQVGGLGIAPGANIGDDGG-AEFEATHGTAPKY------AGKDSTNPGSLILSGTMMLRHRGWLEA 363
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
1-80 8.20e-23

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 88.89  E-value: 8.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585     1 DGDVQSDFLAQGFGSLGLMTSVLVCPDGkTIEAEAAHGTVTRHFRVHQkggetsTNSIASIFAWSRGLAHRAKLDNDARL 80
Cdd:pfam00180 240 FGDILSDEASMLTGSLGLLPSASLGANG-FGIFEPVHGSAPDIAGKGI------ANPIATILSAAMMLRYSLGLEDAADK 312
PLN00096 PLN00096
isocitrate dehydrogenase (NADP+); Provisional
 1-78 4.24e-08

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177715  Cd Length: 393  Bit Score: 48.11  E-value: 4.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932585    1 DGDVQSDFLAQGFGSLGLMTSVLVCPD--GKTI-EAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDND 77
Cdd:PLN00096 267 DGDVLTDELAQVHKSPGFITSNLVGVDenGTLIkEFEASHGTVTDMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHGG 346


                 .
gi 66932585   78 A 78
Cdd:PLN00096 347 K 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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