|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
28-1028 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 590.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAALAMGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVTARF 107
Cdd:COG0841 16 VLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITSTSSEGSSSITVEF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 108 LVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGRGIDDVAIVSLTLSprdgAGDVSANDLTRIA-RELQVQLAKIGDV 186
Cdd:COG0841 96 ELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALS----SDDLDELELSDYAeRNIKDRLERVPGV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 187 GLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEIANLLLTTRDNR 266
Cdd:COG0841 172 GQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFENIVIRTNDGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 267 PVYVRDVADVRfvpDTSERIVANVTRDDSggfrrsPAVTLALAKRAGANAVVVAEEILHRVHLLEHDLiPDSVEVTVTRD 346
Cdd:COG0841 252 VVRLGDVARVE---DGAEDYRSIARLNGK------PAVGLAIQKQPGANALEVADAVRAKLEELQASL-PEGVELTIVYD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 347 YGETANEKANELLFHLGLATV-SIVVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIFSIGILVDD 425
Cdd:COG0841 322 QSEFIRASIEEVVKTLLEAILlVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDD 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 426 AIVVIENIARHWAMpdSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAMIFSFFVAVI 505
Cdd:COG0841 402 AIVVVENIERHMEE--GLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALT 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 506 ITP----WLMVKIAGRAPAHAHDAAAQHGGALGRLYRAVARPLLRTKsgsGLFLLVAAVLsFGSLGALYTRdVTVKLLPF 581
Cdd:COG0841 480 LTPalcaRLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHR---KLTLLVALAL-LALSVLLFGR-LPTEFFPE 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 582 DNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAGdaapFNFNGlvrhyylrARPELGDVQINLLPKDA 661
Cdd:COG0841 555 EDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVG----FSGGG--------SGSNSGTIFVTLKPWDE 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 662 RTRTSHDIALDIRERLStlDLPEGTVLKTVEPPPGPPVIATLLAEVYGPDADSRRAAATRIREAFESVPFVVDVDDSFGT 741
Cdd:COG0841 623 RDRSADEIIARLREKLA--KIPGARVFVFQPPAGGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQL 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 742 QARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVGYSHRGEgrRPIPIEVARDSADRVVDERFLSTPVPANvlpgAR 821
Cdd:COG0841 701 GKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGG--REYDVRVQAPEEDRNSPEDLENLYVRTP----DG 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 822 GVVELGDVVELREERASYPVFRHNGRAAEMVMAELAGDF---EAplygMLAVAEALDAMDWPEGgkpqirlngqpedesv 898
Cdd:COG0841 775 EMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVslgEA----LAAIEELAAELKLPPG---------------- 834
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 899 ITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSAPSMIGFIAL 978
Cdd:COG0841 835 VSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIML 914
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|.
gi 56678146 979 AGIIVRNSILLVDFIRHANPE-RDKIETLIEAGAIRFKPILLTAVAAMIGA 1028
Cdd:COG0841 915 IGIVVKNAILLVDFANQLREEgMSLREAILEAARLRLRPILMTSLATILGL 965
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
30-1028 |
4.90e-117 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 385.88 E-value: 4.90e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 30 ILAALAM---GLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVTAR 106
Cdd:pfam00873 13 LVLAIAIllaGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQSSYGLSSITLT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 107 FLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGRGIDDVAIVSLTLSPRDGAgdVSANDLTRIA-RELQVQLAKIGD 185
Cdd:pfam00873 93 FELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGS--YTQTDLRDYAdTNIKPQLSRVPG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 186 VGLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEIANLLLTTRDN 265
Cdd:pfam00873 171 VGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDFEKIIVKNQDG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 266 RPVYVRDVADVRfvpDTSErivanvTRDDSGGFRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEHDlIPDSVEVTVTR 345
Cdd:pfam00873 251 SPVRLRDVATVE---LGSE------LYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPT-FPQGVEIVVVY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 346 DYGETANEKANELLFHLGLATV-SIVVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIFSIGILVD 424
Cdd:pfam00873 321 DTTPFIRASIEEVVKTLLEAIVlVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 425 DAIVVIENIARHWAMpDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAMIFSFFVAV 504
Cdd:pfam00873 401 DAIVVVENIERVLEE-NGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 505 IITPWLM-VKIAGRAPAHAHDAAAQHGGALGRLYRAVARPLLRTKSGSGLFLLVAAVLSFGSLgALYTRDVTVKLLPFDN 583
Cdd:pfam00873 480 TLTPALCaTLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSV-WLFVRIPTEFLPEEDE 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 584 KSeLSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAGdaapFNFNGLVrhyylrARPELGDVQINLLPKDART 663
Cdd:pfam00873 559 GV-FVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTG----FAFSGDN------NGPNSGDAFISLKPWKERP 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 664 RTSHD---IALDIRERLStlDLPEGTVLKTvEPPP------GPPVIATLLAEVYGPDADSRRAAATRIREAFESVPFVVD 734
Cdd:pfam00873 628 GPEKSvqaLIERLRKALK--QIPGANVFLF-QPIQlrglgtISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSD 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 735 VDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVGYSHRGEGRRPIPIEVarDSADRVVDERFLSTPVPA 814
Cdd:pfam00873 705 VRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQL--PEDFRSSPEDIGQLYVRN 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 815 NvlpgARGVVELGDVVELREERASYPVFRHNGRAAEMVMAELAGDF---EAplygMLAVAEALDAMDWPEGgkpqirlng 891
Cdd:pfam00873 783 P----YGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDslgDA----MEAMAQIAKQVKLPPG--------- 845
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 892 qpedesvITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSAPS 971
Cdd:pfam00873 846 -------YGYTWTGQFEQEQLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYA 918
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*....
gi 56678146 972 MIGFIALAGIIVRNSILLVDFIRHANPERDK--IETLIEAGAIRFKPILLTAVAAMIGA 1028
Cdd:pfam00873 919 QVGLILLIGLAVKNAILMVEFANELREQEGKslEEAILEACRLRLRPILMTALAAILGV 977
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
25-1028 |
4.26e-94 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 322.35 E-value: 4.26e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 25 LTPLMILAALAMGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVT 104
Cdd:NF033617 10 ATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTIT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 105 ARFLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIV-GRGIDDVAIVSLTLSprdgAGDVSANDLTRIA-RELQVQLAK 182
Cdd:NF033617 90 LQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYrKANSADTPIMYIGLT----SEEMPRGQLTDYAeRVLAPKLSQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 183 IGDVGLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEIANLLLTT 262
Cdd:NF033617 166 INGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYEDLVIKY 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 263 RDN-RPVYVRDVADVRFVPDTSerivanvtrDDSGGFRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEHDLiPDSVEV 341
Cdd:NF033617 246 ADNgAPVRLGDVATVELGAENV---------RNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETL-PKNIKV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 342 TVTRDYGETANEKANELLFHLGLAtVSIVVLV--LFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIFSI 419
Cdd:NF033617 316 NVLYDRTRFIRASIDEVESTLLEA-VALVILVvfLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAI 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 420 GILVDDAIVVIENIARHwaMPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAMIFS 499
Cdd:NF033617 395 GLVVDDAIVVVENIHRH--IEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIIS 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 500 FFVAVIITPWLMVKIAgRAPAHAHDAAAQHGGALGRL---YRAVARPLLRTKsgsgLFLLVAAVLSFGSLGALYTRdVTV 576
Cdd:NF033617 473 GIVALTLTPMMCSRLL-KANEKPGRFARAVDRFFDGLtarYGRGLKWVLKHR----PLTLVVALATLALLPLLYVF-IPK 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 577 KLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQThagdaapfnFNGLVRHyylrARPELGDVQINL 656
Cdd:NF033617 547 ELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTS---------FNGVGGN----PGDNTGFGIINL 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 657 LPKDARTRTSHDIALDIRERLSTLDLPEGTVLKTVEPPPG-----PPVIATLLAEvygpDADSRRAAATRIREAFESVPF 731
Cdd:NF033617 614 KPWDERDVSAQEIIDRLRPKLAKVPGMDLFLFPLQDLPGGagsslPQYQVTLTPS----DYDSLFTWAEKLKEKLRKSPQ 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 732 VVDVDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVG-YSHRGEGRRPIPiEVARDSADRVVDERFLst 810
Cdd:NF033617 690 FADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNtIYTDGNQYKVVL-EVDRRYRLNPEALNQI-- 766
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 811 pvpanVLPGARG-VVELGDVVELREERASYPVFRHNGRAAEMVMAELagdfeAPLYGMlavAEALDAMDwpeggkpQIRL 889
Cdd:NF033617 767 -----YVRSNDGkLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNL-----APGVSL---GEAIEALD-------QAAK 826
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 890 NGQPEDesvITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSA 969
Cdd:NF033617 827 ELLPSG---ISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNI 903
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56678146 970 PSMIGFIALAGIIVRNSILLVDFirhANPERDK-----IETLIEAGAIRFKPILLTAVAAMIGA 1028
Cdd:NF033617 904 YAQIGLITLIGLVKKNGILMVEF---ANELQRHqglsrREAIYQAAALRLRPILMTTLAMLLGA 964
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
28-1027 |
1.32e-64 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 237.74 E-value: 1.32e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAALAMGLVA---LISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHV--YSQTGDDYam 102
Cdd:TIGR00914 15 LVLLATLVMAILGiwsYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTrsLSRYGLSQ-- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 103 VTARFLVGTPADTAILRVHDKVRANMDRIPVGIgEPLI--VGRGIDDVAIVSLTLSPRDGAGDVSANDLTRIaRELQ--- 177
Cdd:TIGR00914 93 VTVIFKDGTDLYFARQLVNERLQQARDNLPEGV-SPEMgpISTGLGEIFLYTVEAEEGARKKDGGAYTLTDL-RTIQdwi 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 178 --VQLAKIGDVGLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEI 255
Cdd:TIGR00914 171 irPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQVQSMDDI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 256 ANLLLTTRDNRPVYVRDVADVRFVPDTSERIVANVTRDDSGGfrrspavtlALAKRAGANAVVVAEEILHRVHLLEHDLi 335
Cdd:TIGR00914 251 RNIVIATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLG---------TVFMLIGENSRTVAQAVGDKLETINKTL- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 336 PDSVEVTVTRDYGETANEKANELLFHL--GLATVsIVVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLF 413
Cdd:TIGR00914 321 PEGVEIVTTYDRSQLVDAAIATVKKNLleGALLV-IVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 414 ALIFsiGILVDDAIVVIENIARHWA--------MPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYM 485
Cdd:TIGR00914 400 ALDF--GLIVDGAVVIVENAHRRLAeaqhhhgrQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMF 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 486 SPIPANASAAMIFSFFVAVIITPWLM-VKIAGRAPAHAHDaaaqhggaLGRLYRAVARPLL-RTKSGSGLFLLVAAVLSF 563
Cdd:TIGR00914 478 HPMAFTVVLALAGAMILSLTFVPAAVaLFIRGKVAEKENR--------LMRVLKRRYEPLLeRVLAWPAVVLGAAAVSIV 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 564 GSLGALYTrdVTVKLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAG------DAAPfnfngl 637
Cdd:TIGR00914 550 LVVWIASR--VGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGtaeiatDPMP------ 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 638 vrhyylrarPELGDVQINLLPKDA-RTRTSHDIALDIRERLSTLDLPEGTVLKTvepPPGPPVIATLLA--------EVY 708
Cdd:TIGR00914 622 ---------PNASDTYIILKPESQwPEGKKTKEDLIEEIQEATVRIPGNNYEFT---QPIQMRFNELISgvrsdvavKVF 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 709 GPDADSRRAAATRIREAFESVPFVVDVDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVGYSHRGEGRR 788
Cdd:TIGR00914 690 GDDLDDLDATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRF 769
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 789 PIPIEVARDSADRVVDERFLSTPVPANVLpGARGVVELGDVVELREERASYPVFRHNGRAAEMVMAELAG-DFEAplygm 867
Cdd:TIGR00914 770 DIVIRLPESLRESPQALRQLPIPLPLSED-ARKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGrDLGS----- 843
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 868 lAVAEAldamdwpeggkpQIRLNGQPEDESVITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLT 947
Cdd:TIGR00914 844 -FVDDA------------KKAIAEQVKLPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFT 910
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 948 PVPLTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDFIRHANPERDKI-ETLIEAGAIRFKPILLTAVAAMI 1026
Cdd:TIGR00914 911 GIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLdEAVYEGALTRVRPVLMTALVASL 990
|
.
gi 56678146 1027 G 1027
Cdd:TIGR00914 991 G 991
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
28-1027 |
5.73e-51 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 195.82 E-value: 5.73e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAALAmGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQT-GDDYAMVTAR 106
Cdd:PRK10555 15 LAILLCLT-GTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSsGTGQASVTLS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 107 FLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGRGIDDVAIVSLTLSPRDGAGDvsANDLTR-IARELQVQLAKIGD 185
Cdd:PRK10555 94 FKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMD--KQDIADyVASNIQDPLSRVNG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 186 VGLTYLVGeAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVrdGGeqIALVAGETLHAPAEIANLLLTtrdn 265
Cdd:PRK10555 172 VGDIDAYG-SQYSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQL--GG--TPSVDKQALNATINAQSLLQT---- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 266 rPVYVRDVAdVRFVPDTSERIVANVTRDDSGG--------FRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEHdLIPD 337
Cdd:PRK10555 243 -PEQFRDIT-LRVNQDGSEVTLGDVATVELGAekydylsrFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQ-YFPH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 338 SVEVTVTrdYGETANEKAN-ELLFHLGLATVSIVVLV--LFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFA 414
Cdd:PRK10555 320 GLEYKVA--YETTSFVKASiEDVVKTLLEAIALVFLVmyLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 415 LIFSIGILVDDAIVVIENIARhwAMPDSASRTQKAIR-AVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANAS 493
Cdd:PRK10555 398 MVLAIGLLVDDAIVVVENVER--IMSEEGLTPREATRkSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIV 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 494 AAMIFSFFVAVIITPWLMVKIagrAPAHAHDAAAQHGGALGRLYRAVARPLLRTKSGSGLFL------LVAAVLSFGSLG 567
Cdd:PRK10555 476 SAMVLSVLVAMILTPALCATL---LKPLKKGEHHGQKGFFGWFNRMFNRNAERYEKGVAKILhrslrwILIYVLLLGGMV 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 568 ALYTRDVTvKLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVL--ELPEVISAQTHAGDAAPFNFNGLVRHYylra 645
Cdd:PRK10555 553 FLFLRLPT-SFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFthEKDNVMSVFATVGSGPGGNGQNVARMF---- 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 646 rpelgdvqINLLPKDARTrTSHDIALDIRERLSTL--DLPEGTVLKTvepppGPPVIATL---------LAEVYGPDADS 714
Cdd:PRK10555 628 --------IRLKDWDERD-SKTGTSFAIIERATKAfnKIKEARVIAS-----SPPAISGLgssagfdmeLQDHAGAGHDA 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 715 RRAAATRIREAFESVPFVVDV-----DDSfgtqaRRLRATVSTDQLEFFGVQERDVFSTLailnagQTV-GYSHrgegrr 788
Cdd:PRK10555 694 LMAARNQLLALAAKNPELTRVrhnglDDS-----PQLQIDIDQRKAQALGVSIDDINDTL------QTAwGSSY------ 756
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 789 pipievARDSADR-VVDERFLSTPVPANVLPG----------ARGVVELGDVVELREERASYPVFRHNGRAAEMVMAELA 857
Cdd:PRK10555 757 ------VNDFMDRgRVKKVYVQAAAPYRMLPDdinlwyvrnkDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAA 830
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 858 GDfeaplygmLAVAEALDAMdwpeggkpqirlngqpedESVITLLWDG---EWEVTWITFRDMG----AAFGVALLGIYI 930
Cdd:PRK10555 831 PG--------VSTGTAMDIM------------------ESLVKQLPNGfglEWTAMSYQERLSGaqapALYAISLLVVFL 884
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 931 LVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDFIRHANPE-RDKIETLIEA 1009
Cdd:PRK10555 885 CLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKgHDLFEATLHA 964
|
1050
....*....|....*...
gi 56678146 1010 GAIRFKPILLTAVAAMIG 1027
Cdd:PRK10555 965 SRQRLRPILMTSLAFIFG 982
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
28-1028 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 590.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAALAMGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVTARF 107
Cdd:COG0841 16 VLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITSTSSEGSSSITVEF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 108 LVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGRGIDDVAIVSLTLSprdgAGDVSANDLTRIA-RELQVQLAKIGDV 186
Cdd:COG0841 96 ELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALS----SDDLDELELSDYAeRNIKDRLERVPGV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 187 GLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEIANLLLTTRDNR 266
Cdd:COG0841 172 GQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFENIVIRTNDGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 267 PVYVRDVADVRfvpDTSERIVANVTRDDSggfrrsPAVTLALAKRAGANAVVVAEEILHRVHLLEHDLiPDSVEVTVTRD 346
Cdd:COG0841 252 VVRLGDVARVE---DGAEDYRSIARLNGK------PAVGLAIQKQPGANALEVADAVRAKLEELQASL-PEGVELTIVYD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 347 YGETANEKANELLFHLGLATV-SIVVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIFSIGILVDD 425
Cdd:COG0841 322 QSEFIRASIEEVVKTLLEAILlVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDD 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 426 AIVVIENIARHWAMpdSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAMIFSFFVAVI 505
Cdd:COG0841 402 AIVVVENIERHMEE--GLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALT 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 506 ITP----WLMVKIAGRAPAHAHDAAAQHGGALGRLYRAVARPLLRTKsgsGLFLLVAAVLsFGSLGALYTRdVTVKLLPF 581
Cdd:COG0841 480 LTPalcaRLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHR---KLTLLVALAL-LALSVLLFGR-LPTEFFPE 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 582 DNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAGdaapFNFNGlvrhyylrARPELGDVQINLLPKDA 661
Cdd:COG0841 555 EDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVG----FSGGG--------SGSNSGTIFVTLKPWDE 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 662 RTRTSHDIALDIRERLStlDLPEGTVLKTVEPPPGPPVIATLLAEVYGPDADSRRAAATRIREAFESVPFVVDVDDSFGT 741
Cdd:COG0841 623 RDRSADEIIARLREKLA--KIPGARVFVFQPPAGGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQL 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 742 QARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVGYSHRGEgrRPIPIEVARDSADRVVDERFLSTPVPANvlpgAR 821
Cdd:COG0841 701 GKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGG--REYDVRVQAPEEDRNSPEDLENLYVRTP----DG 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 822 GVVELGDVVELREERASYPVFRHNGRAAEMVMAELAGDF---EAplygMLAVAEALDAMDWPEGgkpqirlngqpedesv 898
Cdd:COG0841 775 EMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVslgEA----LAAIEELAAELKLPPG---------------- 834
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 899 ITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSAPSMIGFIAL 978
Cdd:COG0841 835 VSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIML 914
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|.
gi 56678146 979 AGIIVRNSILLVDFIRHANPE-RDKIETLIEAGAIRFKPILLTAVAAMIGA 1028
Cdd:COG0841 915 IGIVVKNAILLVDFANQLREEgMSLREAILEAARLRLRPILMTSLATILGL 965
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
30-1028 |
4.90e-117 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 385.88 E-value: 4.90e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 30 ILAALAM---GLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVTAR 106
Cdd:pfam00873 13 LVLAIAIllaGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQSSYGLSSITLT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 107 FLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGRGIDDVAIVSLTLSPRDGAgdVSANDLTRIA-RELQVQLAKIGD 185
Cdd:pfam00873 93 FELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGS--YTQTDLRDYAdTNIKPQLSRVPG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 186 VGLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEIANLLLTTRDN 265
Cdd:pfam00873 171 VGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDFEKIIVKNQDG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 266 RPVYVRDVADVRfvpDTSErivanvTRDDSGGFRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEHDlIPDSVEVTVTR 345
Cdd:pfam00873 251 SPVRLRDVATVE---LGSE------LYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPT-FPQGVEIVVVY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 346 DYGETANEKANELLFHLGLATV-SIVVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIFSIGILVD 424
Cdd:pfam00873 321 DTTPFIRASIEEVVKTLLEAIVlVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 425 DAIVVIENIARHWAMpDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAMIFSFFVAV 504
Cdd:pfam00873 401 DAIVVVENIERVLEE-NGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 505 IITPWLM-VKIAGRAPAHAHDAAAQHGGALGRLYRAVARPLLRTKSGSGLFLLVAAVLSFGSLgALYTRDVTVKLLPFDN 583
Cdd:pfam00873 480 TLTPALCaTLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSV-WLFVRIPTEFLPEEDE 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 584 KSeLSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAGdaapFNFNGLVrhyylrARPELGDVQINLLPKDART 663
Cdd:pfam00873 559 GV-FVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTG----FAFSGDN------NGPNSGDAFISLKPWKERP 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 664 RTSHD---IALDIRERLStlDLPEGTVLKTvEPPP------GPPVIATLLAEVYGPDADSRRAAATRIREAFESVPFVVD 734
Cdd:pfam00873 628 GPEKSvqaLIERLRKALK--QIPGANVFLF-QPIQlrglgtISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSD 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 735 VDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVGYSHRGEGRRPIPIEVarDSADRVVDERFLSTPVPA 814
Cdd:pfam00873 705 VRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQL--PEDFRSSPEDIGQLYVRN 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 815 NvlpgARGVVELGDVVELREERASYPVFRHNGRAAEMVMAELAGDF---EAplygMLAVAEALDAMDWPEGgkpqirlng 891
Cdd:pfam00873 783 P----YGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDslgDA----MEAMAQIAKQVKLPPG--------- 845
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 892 qpedesvITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSAPS 971
Cdd:pfam00873 846 -------YGYTWTGQFEQEQLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYA 918
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*....
gi 56678146 972 MIGFIALAGIIVRNSILLVDFIRHANPERDK--IETLIEAGAIRFKPILLTAVAAMIGA 1028
Cdd:pfam00873 919 QVGLILLIGLAVKNAILMVEFANELREQEGKslEEAILEACRLRLRPILMTALAAILGV 977
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
25-1028 |
4.26e-94 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 322.35 E-value: 4.26e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 25 LTPLMILAALAMGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVT 104
Cdd:NF033617 10 ATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTIT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 105 ARFLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIV-GRGIDDVAIVSLTLSprdgAGDVSANDLTRIA-RELQVQLAK 182
Cdd:NF033617 90 LQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYrKANSADTPIMYIGLT----SEEMPRGQLTDYAeRVLAPKLSQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 183 IGDVGLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEIANLLLTT 262
Cdd:NF033617 166 INGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYEDLVIKY 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 263 RDN-RPVYVRDVADVRFVPDTSerivanvtrDDSGGFRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEHDLiPDSVEV 341
Cdd:NF033617 246 ADNgAPVRLGDVATVELGAENV---------RNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETL-PKNIKV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 342 TVTRDYGETANEKANELLFHLGLAtVSIVVLV--LFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIFSI 419
Cdd:NF033617 316 NVLYDRTRFIRASIDEVESTLLEA-VALVILVvfLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAI 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 420 GILVDDAIVVIENIARHwaMPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAMIFS 499
Cdd:NF033617 395 GLVVDDAIVVVENIHRH--IEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIIS 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 500 FFVAVIITPWLMVKIAgRAPAHAHDAAAQHGGALGRL---YRAVARPLLRTKsgsgLFLLVAAVLSFGSLGALYTRdVTV 576
Cdd:NF033617 473 GIVALTLTPMMCSRLL-KANEKPGRFARAVDRFFDGLtarYGRGLKWVLKHR----PLTLVVALATLALLPLLYVF-IPK 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 577 KLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQThagdaapfnFNGLVRHyylrARPELGDVQINL 656
Cdd:NF033617 547 ELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTS---------FNGVGGN----PGDNTGFGIINL 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 657 LPKDARTRTSHDIALDIRERLSTLDLPEGTVLKTVEPPPG-----PPVIATLLAEvygpDADSRRAAATRIREAFESVPF 731
Cdd:NF033617 614 KPWDERDVSAQEIIDRLRPKLAKVPGMDLFLFPLQDLPGGagsslPQYQVTLTPS----DYDSLFTWAEKLKEKLRKSPQ 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 732 VVDVDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVG-YSHRGEGRRPIPiEVARDSADRVVDERFLst 810
Cdd:NF033617 690 FADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNtIYTDGNQYKVVL-EVDRRYRLNPEALNQI-- 766
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 811 pvpanVLPGARG-VVELGDVVELREERASYPVFRHNGRAAEMVMAELagdfeAPLYGMlavAEALDAMDwpeggkpQIRL 889
Cdd:NF033617 767 -----YVRSNDGkLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNL-----APGVSL---GEAIEALD-------QAAK 826
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 890 NGQPEDesvITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSA 969
Cdd:NF033617 827 ELLPSG---ISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNI 903
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56678146 970 PSMIGFIALAGIIVRNSILLVDFirhANPERDK-----IETLIEAGAIRFKPILLTAVAAMIGA 1028
Cdd:NF033617 904 YAQIGLITLIGLVKKNGILMVEF---ANELQRHqglsrREAIYQAAALRLRPILMTTLAMLLGA 964
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
28-1027 |
1.29e-90 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 313.12 E-value: 1.29e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAALAM---GLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHV--YSQTGDdyAM 102
Cdd:COG3696 15 LVLLLTLLLaaaGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVrsISRFGL--SV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 103 VTARFLVGTPADTAILRVHDKVRANMDRIPVGIgEPLI------VGRgiddvaIVSLTLspRDGAGDVSANDLTRIA--- 173
Cdd:COG3696 93 VTVIFEDGTDIYWARQLVLERLQQVREQLPAGV-TPELgpistgLGE------IYQYTL--ESDPGKYSLMELRTLQdwv 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 174 --RELQ-----VQLAKIGdvgltylvGEAPEaIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIaLVAG 246
Cdd:COG3696 164 irPQLRsvpgvAEVNSFG--------GFVKQ-YQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEY-LVRG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 247 ETL-HAPAEIANLLLTTRDNRPVYVRDVADVRFVPDTseRIVAnVTRDDSGgfrrsPAVTLALAKRAGANAVVVAEEILH 325
Cdd:COG3696 234 IGLiRSLEDIENIVVKTRNGTPVLLRDVAEVRIGPAP--RRGA-ATLNGEG-----EVVGGIVLMLKGENALEVIEAVKA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 326 RVHLLEHDLiPDSVEVTVTRDYGEtanekanelLFHLGLATVS----------IVVLVLFSIGWRESIVVAVVIPVTILL 395
Cdd:COG3696 306 KLAELKPSL-PEGVKIVPFYDRSD---------LIDRAIHTVTknllegallvILVLFLFLGNLRAALIVALAIPLSLLF 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 396 TLFAAWVMGYTLNRVSLFALIFSIGILVDDAIVVIENIARH----WAMPDSASRTQKAIRAVAEVGNPTIVATLTVVAAL 471
Cdd:COG3696 376 AFIVMRLFGISANLMSLGGLAIDFGIIVDGAVVMVENILRRleenRAAGTPRERLEVVLEAAREVRRPIFFATLIIILVF 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 472 LPMLFVSGLMGPYMSPIPANASAAMIFSFFVAVIITPWLMVKIAGRAPAHAHDAAAqhgGALGRLYRAVARPLLRTKS-- 549
Cdd:COG3696 456 LPIFTLEGVEGKLFRPMALTVIFALLGALLLSLTLVPVLASLLLRGKVPEKENPLV---RWLKRLYRPLLRWALRHPKlv 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 550 -GSGLFLLVAAVLSFGSLGAlytrdvtvKLLP-FDNKSeLSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAG 627
Cdd:COG3696 533 lAVALVLLVLALALFPRLGS--------EFLPeLDEGD-LLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTG 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 628 ------DAAPFNFnglvrhyylrarpelGDVQINLLPKDA--RTRTSHDIALDIRERLSTLdlpegtvlktveppPG--- 696
Cdd:COG3696 604 raedatDPMGVNM---------------SETFVILKPRSEwrSGRTKEELIAEMREALEQI--------------PGvnf 654
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 697 ---PPvIATLLAE------------VYGPDADSRRAAATRIREAFESVPFVVDVddsfgtQARR------LRATVSTDQL 755
Cdd:COG3696 655 nfsQP-IQMRVDEllsgvradvavkIFGDDLDVLRRLAEQIEAVLKTVPGAADV------QVERvtglpqLDIRIDRDAA 727
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 756 EFFGVQERDVFSTLAILNAGQTVG--YshrgEGRRPIPIEVARDSADRVVDERFLSTPVPanvLPGArGVVELGDVVELR 833
Cdd:COG3696 728 ARYGLNVADVQDVVETAIGGKAVGqvY----EGERRFDIVVRLPEELRDDPEAIRNLPIP---TPSG-AQVPLSQVADIE 799
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 834 EERASYPVFRHNGRAAEMVMAELAG-DFEAplygmlAVAEALDAMDwpeggkPQIRLngqPEDESVItllWDGEWEVTWI 912
Cdd:COG3696 800 VVEGPNQISRENGRRRIVVQANVRGrDLGS------FVAEAQAKVA------EQVKL---PPGYYIE---WGGQFENLQR 861
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 913 TFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDF 992
Cdd:COG3696 862 ATARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSY 941
|
1050 1060 1070
....*....|....*....|....*....|....*.
gi 56678146 993 IRHANPERDKIETLIEAGAI-RFKPILLTAVAAMIG 1027
Cdd:COG3696 942 INQLRAEGLDLREAIIEGALeRLRPVLMTALVAALG 977
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
28-1027 |
1.32e-64 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 237.74 E-value: 1.32e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAALAMGLVA---LISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHV--YSQTGDDYam 102
Cdd:TIGR00914 15 LVLLATLVMAILGiwsYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTrsLSRYGLSQ-- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 103 VTARFLVGTPADTAILRVHDKVRANMDRIPVGIgEPLI--VGRGIDDVAIVSLTLSPRDGAGDVSANDLTRIaRELQ--- 177
Cdd:TIGR00914 93 VTVIFKDGTDLYFARQLVNERLQQARDNLPEGV-SPEMgpISTGLGEIFLYTVEAEEGARKKDGGAYTLTDL-RTIQdwi 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 178 --VQLAKIGDVGLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEI 255
Cdd:TIGR00914 171 irPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQVQSMDDI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 256 ANLLLTTRDNRPVYVRDVADVRFVPDTSERIVANVTRDDSGGfrrspavtlALAKRAGANAVVVAEEILHRVHLLEHDLi 335
Cdd:TIGR00914 251 RNIVIATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLG---------TVFMLIGENSRTVAQAVGDKLETINKTL- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 336 PDSVEVTVTRDYGETANEKANELLFHL--GLATVsIVVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLF 413
Cdd:TIGR00914 321 PEGVEIVTTYDRSQLVDAAIATVKKNLleGALLV-IVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 414 ALIFsiGILVDDAIVVIENIARHWA--------MPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYM 485
Cdd:TIGR00914 400 ALDF--GLIVDGAVVIVENAHRRLAeaqhhhgrQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMF 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 486 SPIPANASAAMIFSFFVAVIITPWLM-VKIAGRAPAHAHDaaaqhggaLGRLYRAVARPLL-RTKSGSGLFLLVAAVLSF 563
Cdd:TIGR00914 478 HPMAFTVVLALAGAMILSLTFVPAAVaLFIRGKVAEKENR--------LMRVLKRRYEPLLeRVLAWPAVVLGAAAVSIV 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 564 GSLGALYTrdVTVKLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAG------DAAPfnfngl 637
Cdd:TIGR00914 550 LVVWIASR--VGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGtaeiatDPMP------ 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 638 vrhyylrarPELGDVQINLLPKDA-RTRTSHDIALDIRERLSTLDLPEGTVLKTvepPPGPPVIATLLA--------EVY 708
Cdd:TIGR00914 622 ---------PNASDTYIILKPESQwPEGKKTKEDLIEEIQEATVRIPGNNYEFT---QPIQMRFNELISgvrsdvavKVF 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 709 GPDADSRRAAATRIREAFESVPFVVDVDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVGYSHRGEGRR 788
Cdd:TIGR00914 690 GDDLDDLDATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRF 769
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 789 PIPIEVARDSADRVVDERFLSTPVPANVLpGARGVVELGDVVELREERASYPVFRHNGRAAEMVMAELAG-DFEAplygm 867
Cdd:TIGR00914 770 DIVIRLPESLRESPQALRQLPIPLPLSED-ARKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGrDLGS----- 843
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 868 lAVAEAldamdwpeggkpQIRLNGQPEDESVITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLT 947
Cdd:TIGR00914 844 -FVDDA------------KKAIAEQVKLPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFT 910
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 948 PVPLTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDFIRHANPERDKI-ETLIEAGAIRFKPILLTAVAAMI 1026
Cdd:TIGR00914 911 GIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLdEAVYEGALTRVRPVLMTALVASL 990
|
.
gi 56678146 1027 G 1027
Cdd:TIGR00914 991 G 991
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
30-1027 |
2.23e-58 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 218.83 E-value: 2.23e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 30 ILAALAM--GLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAM-VTAR 106
Cdd:TIGR00915 14 VIAIIIMlaGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSDGSMtITLT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 107 FLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGRGIDDVAIVSLTLSPRDGAgdVSANDLTR-IARELQVQLAKIGD 185
Cdd:TIGR00915 94 FEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRVEKASSNFLMVIGLVSDDGS--MTKEDLSDyAASNMVDPLSRLEG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 186 VGLTYLVGeAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLV-----RDGGEQIALVAGET-LHAPAEIANLL 259
Cdd:TIGR00915 172 VGDVQLFG-SQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpaVPGQQLNATIIAQTrLQTPEQFENIL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 260 L-TTRDNRPVYVRDVADVRFVPDTSerivanvtrDDSGGFRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEHDLiPDS 338
Cdd:TIGR00915 251 LkVNTDGSQVRLKDVARVELGGENY---------SISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFF-PQG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 339 VEVTVTRDYGETANEKANELLFHLGLATV-SIVVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIF 417
Cdd:TIGR00915 321 MKYVYPYDTTPFVEASIEEVVHTLIEAIVlVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 418 SIGILVDDAIVVIENIARhwAMPDSASRTQKAIR-AVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAM 496
Cdd:TIGR00915 401 AIGLLVDDAIVVVENVER--VMAEEGLPPKEATRkSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 497 IFSFFVAVIITPWL---MVKiagrapahaHDAAAQHGGALGRLYRAVARPLLRTKSGSG----------LFLLVAAVLSF 563
Cdd:TIGR00915 479 ALSVLVALILTPALcatMLK---------PIEKGEHHEKKGGFFGWFNRMFDSSTHGYEngvgkilrrrGRYLLVYVLLV 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 564 GSLGALYTRdVTVKLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVL--ELPEVISAQTHAGdaapFNFNGlvrhy 641
Cdd:TIGR00915 550 GGMVFLFVR-LPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLakEKANVESVFTVNG----FSFAG----- 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 642 ylrARPELGDVQINLLPKDARTRTSHDI-ALDIRERLSTLDLPEGTVLktvepPPGPPVIATL---------LAEVYGPD 711
Cdd:TIGR00915 620 ---RGQNMGMAFIRLKDWEERTGKENSVfAIAGRATGHFMQIKDAMVI-----AFVPPAILELgnatgfdffLQDRAGLG 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 712 ADSRRAAATRIREAFESVPFVVDVDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVG-YSHRGEGRRpi 790
Cdd:TIGR00915 692 HEALLQARNQLLGLAAQNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNdFIDRGRVKR-- 769
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 791 pIEVARDSADRVVDERFLSTPVPAnvlpGARGVVELGDVVELREERASYPVFRHNGRAAEMVMAELAGDF---EAplygM 867
Cdd:TIGR00915 770 -VYVQAEEDARMSPEDINKWYVRN----ASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVstgQA----M 840
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 868 LAVAEALDAMdwPEGgkpqirlngqpedesvITLLWDGewevtwITFRDMGAA------FGVALLGIYILVVAQFGSFRL 941
Cdd:TIGR00915 841 AAMEAIAQKL--PPG----------------FGFSWTG------MSYEERLSGsqapalYALSLLVVFLCLAALYESWSI 896
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 942 PLVVLTPVPLTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDFIRHANPE-RDKIETLIEAGAIRFKPILLT 1020
Cdd:TIGR00915 897 PVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQgKSIVEAALEAARLRLRPILMT 976
|
....*..
gi 56678146 1021 AVAAMIG 1027
Cdd:TIGR00915 977 SLAFILG 983
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
28-1027 |
5.73e-51 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 195.82 E-value: 5.73e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAALAmGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQT-GDDYAMVTAR 106
Cdd:PRK10555 15 LAILLCLT-GTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSsGTGQASVTLS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 107 FLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGRGIDDVAIVSLTLSPRDGAGDvsANDLTR-IARELQVQLAKIGD 185
Cdd:PRK10555 94 FKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMD--KQDIADyVASNIQDPLSRVNG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 186 VGLTYLVGeAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVrdGGeqIALVAGETLHAPAEIANLLLTtrdn 265
Cdd:PRK10555 172 VGDIDAYG-SQYSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQL--GG--TPSVDKQALNATINAQSLLQT---- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 266 rPVYVRDVAdVRFVPDTSERIVANVTRDDSGG--------FRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEHdLIPD 337
Cdd:PRK10555 243 -PEQFRDIT-LRVNQDGSEVTLGDVATVELGAekydylsrFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQ-YFPH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 338 SVEVTVTrdYGETANEKAN-ELLFHLGLATVSIVVLV--LFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFA 414
Cdd:PRK10555 320 GLEYKVA--YETTSFVKASiEDVVKTLLEAIALVFLVmyLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 415 LIFSIGILVDDAIVVIENIARhwAMPDSASRTQKAIR-AVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANAS 493
Cdd:PRK10555 398 MVLAIGLLVDDAIVVVENVER--IMSEEGLTPREATRkSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIV 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 494 AAMIFSFFVAVIITPWLMVKIagrAPAHAHDAAAQHGGALGRLYRAVARPLLRTKSGSGLFL------LVAAVLSFGSLG 567
Cdd:PRK10555 476 SAMVLSVLVAMILTPALCATL---LKPLKKGEHHGQKGFFGWFNRMFNRNAERYEKGVAKILhrslrwILIYVLLLGGMV 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 568 ALYTRDVTvKLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVL--ELPEVISAQTHAGDAAPFNFNGLVRHYylra 645
Cdd:PRK10555 553 FLFLRLPT-SFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFthEKDNVMSVFATVGSGPGGNGQNVARMF---- 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 646 rpelgdvqINLLPKDARTrTSHDIALDIRERLSTL--DLPEGTVLKTvepppGPPVIATL---------LAEVYGPDADS 714
Cdd:PRK10555 628 --------IRLKDWDERD-SKTGTSFAIIERATKAfnKIKEARVIAS-----SPPAISGLgssagfdmeLQDHAGAGHDA 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 715 RRAAATRIREAFESVPFVVDV-----DDSfgtqaRRLRATVSTDQLEFFGVQERDVFSTLailnagQTV-GYSHrgegrr 788
Cdd:PRK10555 694 LMAARNQLLALAAKNPELTRVrhnglDDS-----PQLQIDIDQRKAQALGVSIDDINDTL------QTAwGSSY------ 756
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 789 pipievARDSADR-VVDERFLSTPVPANVLPG----------ARGVVELGDVVELREERASYPVFRHNGRAAEMVMAELA 857
Cdd:PRK10555 757 ------VNDFMDRgRVKKVYVQAAAPYRMLPDdinlwyvrnkDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAA 830
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 858 GDfeaplygmLAVAEALDAMdwpeggkpqirlngqpedESVITLLWDG---EWEVTWITFRDMG----AAFGVALLGIYI 930
Cdd:PRK10555 831 PG--------VSTGTAMDIM------------------ESLVKQLPNGfglEWTAMSYQERLSGaqapALYAISLLVVFL 884
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 931 LVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDFIRHANPE-RDKIETLIEA 1009
Cdd:PRK10555 885 CLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKgHDLFEATLHA 964
|
1050
....*....|....*...
gi 56678146 1010 GAIRFKPILLTAVAAMIG 1027
Cdd:PRK10555 965 SRQRLRPILMTSLAFIFG 982
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
25-1027 |
1.99e-48 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 187.73 E-value: 1.99e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 25 LTPLMILAALAMGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVT 104
Cdd:PRK09579 13 LASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQNFSIIS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 105 ARFLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGRGIDDVAIVSLTLSPRDGAGDVSANDLTRIareLQVQLAKIG 184
Cdd:PRK09579 93 IYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADASALMYISFYSEEMSNPQITDYLSRV---IQPKLATLP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 185 DVGLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEIANLLLTTRD 264
Cdd:PRK09579 170 GMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAFAAIPVKTSG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 265 NRPVYVRDVADVRFVPDTSERIVAnvtrddsggFRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEHDLiPDSVEVTVT 344
Cdd:PRK09579 250 DSRVLLGDVARVEMGAENYDSISS---------FDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQL-PPNLKVSIA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 345 RDYGETANEKANELLFHLGLATVSIVVLVLFSIGWRESIVVAVV-IPVTILLTLFAAWVMGYTLNRVSLFALIFSIGILV 423
Cdd:PRK09579 320 YDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVtIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 424 DDAIVVIENIARHwaMPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAMIFSFFVA 503
Cdd:PRK09579 400 DDAIVVVENIHRH--IEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVA 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 504 VIITPwLMVKIAGRAPAHAHDAAAQHGGALGRLYRAVARPLLRTKSGSGLfLLVAAVLSFGSLGAL--YTRDvtvKLLPF 581
Cdd:PRK09579 478 LTLSP-MMCALLLRHEENPSGLAHRLDRLFERLKQRYQRALHGTLNTRPV-VLVFAVIVLALIPVLlkFTQS---ELAPE 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 582 DNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAGdaapfnFNGLvrhyylrarpELGDVQINLLPKDA 661
Cdd:PRK09579 553 EDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQING------FNGV----------QSGIGGFLLKPWNE 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 662 RTRTSHDIALDIRERLSTL--------DLPegTVLKTVEPPPGPPVIATllaevyGPDADSRRAAATRIRE-AFESVPFV 732
Cdd:PRK09579 617 RERTQMELLPLVQAKLEEIpglqifgfNLP--SLPGTGEGLPFQFVINT------ANDYESLLQVAQRVKQrAQESGKFA 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 733 -VDVDDSFGtqarRLRATVSTDQLEF--FGVQERDVFSTLA-ILNAGQTVGYSHRGEGRRPIP-IEVA-RDSADrvvder 806
Cdd:PRK09579 689 fLDIDLAFD----KPEVVVDIDRAKAaqMGVSMQDLGGTLAtLLGEGEINRFTIDGRSYKVIAqVERPyRDNPG------ 758
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 807 FLSTPVPANvlpgARG-VVELGDVVELREERASypvfRHNGRAAEMVMAELAGdfeAPLYGMlavAEALDAMDwpeggkp 885
Cdd:PRK09579 759 WLNNYYVKN----EQGqLLPLSTLITLSDRARP----RQLNQFQQLNSAIISG---FPIVSM---GEAIETVQ------- 817
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 886 QIRLNGQPE----DESVITLLWDGEWEVTWITfrdmgaaFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHW 961
Cdd:PRK09579 818 QIAREEAPEgfafDYAGASRQYVQEGSALWVT-------FGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLF 890
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56678146 962 LFNAPFSAPSMIGFIALAGIIVRNSILLVDF---IRHAN--PERDKIEtliEAGAIRFKPILLTAVAAMIG 1027
Cdd:PRK09579 891 LGVSSMNIYTQVGLVTLIGLISKHGILIVEFanqLRHEQglSRREAIE---EAAAIRLRPVLMTTAAMVFG 958
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
28-1027 |
7.68e-40 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 160.40 E-value: 7.68e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAalamGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVTARF 107
Cdd:PRK09577 18 FIMLG----GIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSLTF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 108 LVGTPADTAILRVHDKVRANMDRIPVGIGEPLI-VGRGIDDVA-IVSLTLSprdgAGDVSANDLTRIARELQVQ-LAKIG 184
Cdd:PRK09577 94 KQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIqVEKAADNIQlIVSLTSD----DGRLTGVELGEYASANVLQaLRRVE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 185 DVGLTYLVGeAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGG----EQIA--LVAGETLHAPAEIANL 258
Cdd:PRK09577 170 GVGKVQFWG-AEYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSAvpdsAPIAatVFADAPLKTPEDFGAI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 259 LLTTR-DNRPVYVRDVADVRFvPDTSERIVANVTRDDSGGFrrspAVTLAlakrAGANAVVVAEEILHRVHLLEHdLIPD 337
Cdd:PRK09577 249 ALRARaDGSALYLRDVARIEF-GGNDYNYPSYVNGKTATGM----GIKLA----PGSNAVATEKRVRATMDELSR-YFPP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 338 SVEVTVTRDYGETANEKANELLFHLGLATVSI-VVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALI 416
Cdd:PRK09577 319 GVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVfLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 417 FSIGILVDDAIVVIENIARHWAmPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAM 496
Cdd:PRK09577 399 LAIGILVDDAIVVVENVERLMV-EEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSI 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 497 IFSFFVAVIITPWLMVKIagraPAHAHDAAAQHGGALGRLYRAVARPLLR--TKSGSGLFLLVAAVLSFGSLGA----LY 570
Cdd:PRK09577 478 GFSAFLALSLTPALCATL----LKPVDGDHHEKRGFFGWFNRFVARSTQRyaTRVGAILKRPLRWLVVYGALTAaaalLF 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 571 TRdVTVKLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAGdaapFNFNGlvrhyylrARPELG 650
Cdd:PRK09577 554 TR-LPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGG----FNLYG--------EGPNGG 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 651 DVQINLlpKDARTRTSHD-----IALDIRERLStlDLPEGTVLkTVEPPPGPPVIAT-----LLAEVYGPDADSRRAAAT 720
Cdd:PRK09577 621 MIFVTL--KDWKERKAARdhvqaIVARINERFA--GTPNTTVF-AMNSPALPDLGSTsgfdfRLQDRGGLGYAAFVAARE 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 721 RIREAFESVPFVVDVDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVG-YSHRGEGRRPIpieVARDSA 799
Cdd:PRK09577 696 QLLAEGAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGdFMHGSQVRRVI---VQADGR 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 800 DRVVDERFLSTPVpanvlPGARG-VVELGDVVELR--------EERASYPVFRHNGRAaemvmaelagdfeAPLYgmlAV 870
Cdd:PRK09577 773 HRLDPDDVKKLRV-----RNAQGeMVPLAAFATLHwtlgppqlTRYNGYPSFTINGSA-------------APGH---SS 831
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 871 AEALDAMDWPEGGKPqirlngqpedeSVITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVP 950
Cdd:PRK09577 832 GEAMAAIERIAATLP-----------AGIGYAWSGQSFEERLSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVP 900
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56678146 951 LTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDFIRHANPER-DKIETLIEAGAIRFKPILLTAVAAMIG 1027
Cdd:PRK09577 901 LGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVAQRmSLADAALEAARLRLRPIVMTSLAFGVG 978
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
26-1028 |
3.00e-39 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 158.35 E-value: 3.00e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 26 TPLMILAALAMGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVYSQTGDDYAMVTA 105
Cdd:PRK10614 14 TILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 106 RFLVGTPADTAILRVHDKVRANMDRIPVGI-GEPLIVGRGIDDVAIVSLTL-SPRDGAGDVSANDLTRIARELQvQLAKI 183
Cdd:PRK10614 94 QFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLtSDTYSQGQLYDFASTQLAQTIS-QIDGV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 184 GDVGLTylvGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALVAGETLHAPAEIANLLLTTR 263
Cdd:PRK10614 173 GDVDVG---GSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLIIHYN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 264 DNRPVYVRDVADVRfvpDTseriVANVTrdDSGGFRRSPAVTLALAKRAGANAVVVAEEILHRVHLLeHDLIPDSVEVTV 343
Cdd:PRK10614 250 NGAAVRLGDVATVT---DS----VQDVR--NAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPEL-RETIPAAIDLQI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 344 TRDYGETANEKANELLFHLGLAtVSIVVLV--LFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIFSIGI 421
Cdd:PRK10614 320 AQDRSPTIRASLEEVEQTLAIS-VALVILVvfLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGF 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 422 LVDDAIVVIENIARHwaMPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPANASAAMIFSFF 501
Cdd:PRK10614 399 VVDDAIVVLENISRH--LEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLL 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 502 VAVIITPWLMVKIAGRAPAHAHDAAAQHGGALGRLYRAVARPLLRTKSGSGLFLLVaaVLSFGSLGALYTRDVTVKLLPF 581
Cdd:PRK10614 477 VSLTLTPMMCAWLLKSSKPREQKRLRGFGRMLVALQQGYGRSLKWVLNHTRWVGVV--LLGTIALNVWLYISIPKTFFPE 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 582 DNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHAGDaapfnfnglvrhyylrARPELGDVQINLLPKDA 661
Cdd:PRK10614 555 QDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGG----------------SRVNSGMMFITLKPLSE 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 662 RTRTSHDIALDIRERLS-----TLDLPEGTVLKTVEPPPGPPVIATLLAEvygpDADSRRAAATRIREAFESVPFVVDVD 736
Cdd:PRK10614 619 RSETAQQVIDRLRVKLAkepgaNLFLMAVQDIRVGGRQSNASYQYTLLSD----DLAALREWEPKIRKALAALPELADVN 694
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 737 DSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVGYSHRGEGRRPIPIEVA-RDSAD-RVVDERFL----ST 810
Cdd:PRK10614 695 SDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDpRYTQDiSALEKMFVinneGK 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 811 PVPanvlpgargvveLGDVVELREERASYPVfRHNGRAAEMVMAelagdFEAPLYGML-----AVAEALDAMDWPEGGKP 885
Cdd:PRK10614 775 AIP------------LSYFAKWQPANAPLSV-NHQGLSAASTIS-----FNLPTGKSLsdasaAIERAMTQLGVPSTVRG 836
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 886 QIRLNGQPEDESVITLLWdgewevtwitfrdmgaAFGVALLGIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNA 965
Cdd:PRK10614 837 SFAGTAQVFQETMNSQLI----------------LILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNA 900
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56678146 966 PFSAPSMIGFIALAGIIVRNSILLVDFIRHANPErDKI---ETLIEAGAIRFKPILLTAVAAMIGA 1028
Cdd:PRK10614 901 PFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRN-GNLtaqEAIFQACLLRFRPIMMTTLAALFGA 965
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
6-1028 |
2.25e-36 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 149.50 E-value: 2.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 6 QNTPLGIAGGLTRGFIGSAL-TPLMILAALAMGLVALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVK 84
Cdd:PRK10503 2 QVLPPSSTGGPSRLFILRPVaTTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 85 AIGDVDHVYSQTGDDYAMVTARFLVGTPADTAILRVHDKVRANMDRIPVGIGEPLIVGR------GIDDVAIVSLTLSPR 158
Cdd:PRK10503 82 QMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKvnpadpPIMTLAVTSTAMPMT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 159 DGAGDVSandlTRIARelqvQLAKIGDVGLTYLVGEAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGG 238
Cdd:PRK10503 162 QVEDMVE----TRVAQ----KISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 239 EQIALVAGETLHAPAEIANLLLTTRDNRPVYVRDVADVRFVPDTSERIV-ANvtrddsggfrRSPAVTLALAKRAGANAV 317
Cdd:PRK10503 234 RAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAwAN----------KQQAIVMNVQRQPGANII 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 318 VVAEEILHRVHLLEHDLiPDSVEVTVTRDYGETANEKANELLFHLGLAtVSIVVLV--LFSIGWRESIVVAVVIPVTILL 395
Cdd:PRK10503 304 ATADSIRQMLPQLTESL-PKSVKVTVLSDRTTNIRASVDDTQFELMLA-IALVVMIiyLFLRNIPATIIPGVAVPLSLIG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 396 TLFAAWVMGYTLNRVSLFALIFSIGILVDDAIVVIENIARHWAMPDSAsrTQKAIRAVAEVGNPTIVATLTVVAALLPML 475
Cdd:PRK10503 382 TFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKP--LAAALKGAGEIGFTIISLTFSLIAVLIPLL 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 476 FVSGLMGPYMSPIPANASAAMIFSFFVAVIITPWLMVKIAGRAPAHAHdaaaqhggalGRLYRAVARPLLRTKSGSGLFL 555
Cdd:PRK10503 460 FMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSQESLRKQ----------NRFSRASERMFDRVIAAYGRGL 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 556 LVAAVLSFGSLG-ALYTRDVTVKL--------LPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVLELPEVISAQTHA 626
Cdd:PRK10503 530 AKVLNHPWLTLSvALSTLLLTVLLwifipkgfFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFV 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 627 G-DAAPFNFNGlvrhyylrarpelGDVQINLLPKDARTRTSHDIALDIRERLSTLdlpegTVLKTVEPPPGPPVIATLLA 705
Cdd:PRK10503 610 GvDGTNPSLNS-------------ARLQINLKPLDERDDRVQKVIARLQTAVAKV-----PGVDLYLQPTQDLTIDTQVS 671
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 706 EV---YGPDADSRRAAAT---RIREAFESVPFVVDVDDSFgtQARRLRATVSTDqleffgvqeRDVFSTLAILNAgQTVG 779
Cdd:PRK10503 672 RTqyqFTLQATSLDALSTwvpKLMEKLQQLPQLSDVSSDW--QDKGLVAYVNVD---------RDSASRLGISMA-DVDN 739
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 780 YSHRGEGRRPIPIEVARDSADRVVDERFLSTPVPANVLPGARGVVELGDVVELR-----EERASYPVFRH-NGRAAEMVM 853
Cdd:PRK10503 740 ALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSsiatiEQRFGPLSINHlDQFPSTTIS 819
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 854 AELAGDFeaplygmlAVAEALDAMDWPEggkpqiRLNGQPEDesvITLLWDGewevTWITFRdmgAAFG-------VALL 926
Cdd:PRK10503 820 FNVPDGY--------SLGDAVQAIMDTE------KTLNLPAD---ITTQFQG----STLAFQ---SALGstvwlivAAVV 875
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 927 GIYILVVAQFGSFRLPLVVLTPVPLTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDFIRHAnpERDK---- 1002
Cdd:PRK10503 876 AMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAA--EREQgmsp 953
|
1050 1060
....*....|....*....|....*.
gi 56678146 1003 IETLIEAGAIRFKPILLTAVAAMIGA 1028
Cdd:PRK10503 954 RDAIYQACLLRFRPILMTTLAALLGA 979
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
28-1027 |
5.31e-35 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 145.05 E-value: 5.31e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 28 LMILAALAMGLvALISLPREEEPQISVPLVDIHIQAPGLKAEDAVKLVTEPMETIVKAIGDVDHVySQTGDDYAMV--TA 105
Cdd:PRK15127 15 IAIIIMLAGGL-AILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYM-SSNSDSTGTVqiTL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 106 RFLVGTPADTAILRVHDKVRANMDRIPVGIGEPLI-VGRGIDDVAIVSLTLSPRdgaGDVSANDLTR-IARELQVQLAKI 183
Cdd:PRK15127 93 TFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVsVEKSSSSFLMVVGVINTD---GTMTQEDISDyVAANMKDPISRT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 184 GDVGLTYLVGeAPEAIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDG----GEQI--ALVAGETLHAPAEIAN 257
Cdd:PRK15127 170 SGVGDVQLFG-SQYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGTppvkGQQLnaSIIAQTRLTSTEEFGK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 258 LLL-TTRDNRPVYVRDVADVRFVPDTSErIVANvtrddsggFRRSPAVTLALAKRAGANAVVVAEEILHRVHLLEhDLIP 336
Cdd:PRK15127 249 ILLkVNQDGSRVRLRDVAKIELGGENYD-IIAE--------FNGQPASGLGIKLATGANALDTAAAIRAELAKME-PFFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 337 DSVEVTVTRDYGETANEKANELLFHLGLATVSI-VVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFAL 415
Cdd:PRK15127 319 SGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVfLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 416 IFSIGILVDDAIVVIENIARHWAM----PDSASRtqkaiRAVAEVGNPTIVATLTVVAALLPMLFVSGLMGPYMSPIPAN 491
Cdd:PRK15127 399 VLAIGLLVDDAIVVVENVERVMAEeglpPKEATR-----KSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSIT 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 492 ASAAMIFSFFVAVIITPWL---MVK-------------IAGRAPAHAHDAAAQHGGALGRLYRAVARPLLrtksgsgLFL 555
Cdd:PRK15127 474 IVSAMALSVLVALILTPALcatMLKpiakgdhgegkkgFFGWFNRMFEKSTHHYTDSVGNILRSTGRYLV-------LYL 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 556 LVAAVLSFgslgaLYTRdVTVKLLPFDNKSELSVVIDLPEGASVEDTDAVAQQVARRVL--ELPEVISAQTHAGdaapFN 633
Cdd:PRK15127 547 IIVVGMAY-----LFVR-LPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLtkEKNNVESVFAVNG----FG 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 634 FNGlvrhyylRARpELGDVQINLLPKDARTRTSHDI-ALDIRERLSTLDLPEGTVLktvepPPGPPVIATL--------- 703
Cdd:PRK15127 617 FAG-------RGQ-NTGIAFVSLKDWADRPGEENKVeAITMRATRAFSQIKDAMVF-----AFNLPAIVELgtatgfdfe 683
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 704 LAEVYGPDADSRRAAATRI-REAFESVPFVVDVDDSFGTQARRLRATVSTDQLEFFGVQERDVFSTLAILNAGQTVG-YS 781
Cdd:PRK15127 684 LIDQAGLGHEKLTQARNQLlGEAAKHPDMLVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNdFI 763
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 782 HRGEGRRpipIEVARDSadrvvDERFLSTPVPANVLPGARG-VVELGDVVELREERASYPVFRHNGRAAEMVMAELAGDf 860
Cdd:PRK15127 764 DRGRVKK---VYVMSEA-----KYRMLPDDIGDWYVRAADGqMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG- 834
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 861 eaplygmLAVAEALDAMDWPEGGKPqirlngqpedeSVITLLWDGEWEVTWITFRDMGAAFGVALLGIYILVVAQFGSFR 940
Cdd:PRK15127 835 -------KSTGEAMELMEELASKLP-----------TGVGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWS 896
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 941 LPLVVLTPVPLTFLGIIIGHWLFNAPFSAPSMIGFIALAGIIVRNSILLVDFIRHANPERDK--IETLIEAGAIRFKPIL 1018
Cdd:PRK15127 897 IPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKglIEATLEAVRMRLRPIL 976
|
....*....
gi 56678146 1019 LTAVAAMIG 1027
Cdd:PRK15127 977 MTSLAFILG 985
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
367-624 |
4.40e-12 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 70.27 E-value: 4.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 367 VSIVVLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVS--LFALIFSIGIlvDDAIVVI----ENIARHwamp 440
Cdd:COG1033 230 LILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTilVPPLLLAIGI--DYGIHLLnryrEERRKG---- 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 441 dsASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFvsglmgpymSPIPA------NASAAMIFSFFVAVIITPWLMVKI 514
Cdd:COG1033 304 --LDKREALREALRKLGPPVLLTSLTTAIGFLSLLF---------SDIPPirdfgiVAAIGVLLAFLTSLTLLPALLSLL 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 515 AGRapaHAHDAAAQHGGALGRLYRAVARPLLRTKSGSGLFLLVAAVLSFGSLGALYTRDVTVKLLP-------------- 580
Cdd:COG1033 373 PRP---KPKTRRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPedspirqdldfiee 449
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 56678146 581 -FDNKSELSVVIDLPEGASVEDTDAVA--QQVARRVLELPEVISAQT 624
Cdd:COG1033 450 nFGGSDPLEVVVDTGEPDGLKDPEVLKeiDRLQDYLESLPEVGKVLS 496
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
169-479 |
1.40e-10 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 65.82 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 169 LTRIARELQVQLAKI---GDVGLTYLVGeAPEaIRIAPDPERLALYGVTLQQLAAKVEGANRALATGLVRDGGEQIALV- 244
Cdd:COG3696 687 LRRLAEQIEAVLKTVpgaADVQVERVTG-LPQ-LDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVv 764
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 245 --AGETLHAPAEIANLLLTTRDNRPVYVRDVADVRFVP--------DTSERIV--ANVTRDDSGGFrrspavtLALAKRA 312
Cdd:COG3696 765 rlPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEgpnqisreNGRRRIVvqANVRGRDLGSF-------VAEAQAK 837
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 313 ganavvVAEEilhrVHLlehdliPDSVEVTVTrdyGETAN-EKANELLFHLGLATVSIVVLVLFSI--GWRESIVVAVVI 389
Cdd:COG3696 838 ------VAEQ----VKL------PPGYYIEWG---GQFENlQRATARLAIVVPLALLLIFLLLYLAfgSVRDALLILLNV 898
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 390 PVTILLTLFAAWVMGYTLNrVS-------LFalifsiGILVDDAIVVIENIARHWAmpDSASRTQKAIRAVAEVGNPTIV 462
Cdd:COG3696 899 PFALIGGVLALWLRGMPLS-VSagvgfiaLF------GVAVLNGVVLVSYINQLRA--EGLDLREAIIEGALERLRPVLM 969
|
330
....*....|....*..
gi 56678146 463 ATLTVVAALLPMLFVSG 479
Cdd:COG3696 970 TALVAALGLLPMALSTG 986
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
336-517 |
6.11e-09 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 60.26 E-value: 6.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 336 PDSVEVTVTrdyGETANEKA-NELLFH---LGLATVSIVVLVLFSIGWReSIVVAVVIPVTILLT-LFAAWVMGYTlnRV 410
Cdd:COG1033 582 PDGVEVTLT---GSAVLFAAiNESVIEsqiRSLLLALLLIFLLLLLAFR-SLRLGLISLIPNLLPiLLTFGLMGLL--GI 655
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 411 SLF---ALIFSI--GILVDDAIVVIENIARHWAmpDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFvsglmgpym 485
Cdd:COG1033 656 PLNiatAVVASIalGIGVDYTIHFLSRYREERR--KGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLF--------- 724
|
170 180 190
....*....|....*....|....*....|....*...
gi 56678146 486 SPIPANA------SAAMIFSFFVAVIITPWLMVKIAGR 517
Cdd:COG1033 725 SSFPPLAdfglllALGLLVALLAALLLLPALLLLLDPR 762
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
225-624 |
7.61e-06 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 50.15 E-value: 7.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 225 ANRALATGLVRDGGEQIALVagetLHAPaeiaNLLLTTRDNRPVYVRDVADVRFVPDTSEriVANVTRDDSGGF----RR 300
Cdd:COG2409 45 AADLLAEAFPESDGASAVVV----VEAP----DGTLTDPAFRAAVAALVARLRADPGVAG--VQDPWDDPAAGLvsedGK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 301 SPAVTLALAKRAGANAVVVAEEILHRVHllehDLIPDSVEVTVTrdyGETA-----NEKANELLFHLGLATVSIVVLVLF 375
Cdd:COG2409 115 AALVTVTLDGDAGDEAAEAVDALRDAVA----AAPAPGLTVYVT---GPAAlaadlNEAFEEDLGRAELITLPVALVVLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 376 sIGWReSIVVAVVIPVTILLTLFAAWVMGYTLNRV-------SLFALIFSIGILVDDAIVVI----ENIARHwampdsAS 444
Cdd:COG2409 188 -LVFR-SLVAALLPLLTAGLAVGVALGLLALLAAFtdvssfaPNLLTMLGLGVGIDYALFLVsryrEELRAG------ED 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 445 RTQKAIRAVAEVGNPTIVATLTVVAALLpMLFVSGLmgPYMSPIPANASAAMIFSFFVAVIITPWLMVKIAGRAPAHAHD 524
Cdd:COG2409 260 REEAVARAVATAGRAVLFSGLTVAIALL-GLLLAGL--PFLRSMGPAAAIGVAVAVLAALTLLPALLALLGRRVFWPRRP 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 525 AAAQHGGALGRLYRAVARPLLR----TKSGSGLFLLVAAV------LSFGSLGALyTRDVTVKL--------LPFDNKSE 586
Cdd:COG2409 337 RRRRAAAPESGFWRRLARAVVRrpvpVLVAAVAVLLALALpalglrLGLPDADSL-PADSPSRQgydalaehFPPGSNGP 415
|
410 420 430
....*....|....*....|....*....|....*...
gi 56678146 587 LSVVIDLPEGASVEDTDAVAQqVARRVLELPEVISAQT 624
Cdd:COG2409 416 LTVVVESDDDLDPADLAALDA-LAAALAAVPGVASVQP 452
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
362-545 |
4.64e-05 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 46.90 E-value: 4.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 362 LGLATVSIVVLVLFSIgwRESIVVAVVIPVTILLTLFAAWVMGYTLN-----RVSLFALIFSIGILV----DDAIVVIEN 432
Cdd:pfam03176 147 IEAVTLVVIFIILLIV--YRSVVAALLPLLTVGLSLGAAQGLVAILAhilgiGLSTFALNLLVVLLIavgtDYALFLVSR 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 433 IarHWAMPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSglmGPYMSPIPANASAAMIFSFFVAVIITPWLMV 512
Cdd:pfam03176 225 Y--REELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFAR---LPVFAQVGPTIAIGVLVDVLAALTLLPALLA 299
|
170 180 190
....*....|....*....|....*....|...
gi 56678146 513 kIAGRAPAHAHDAAAQHGGALGRLYRAVARPLL 545
Cdd:pfam03176 300 -LLGRWGLWPPKRDRTARWWRRIGRLVVRRPAP 331
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
359-466 |
7.36e-05 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 47.21 E-value: 7.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 359 LFHLGLATVSIVVLVLFSIGWRESIVVAVVIPVTILLT--LFAAWVMGYTLNRVSLFALIFSIGIlvddAIVVIENIARH 436
Cdd:TIGR00917 1052 IINLSIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVfcVGIMHLWSISLNAVSVVNSVMHKGI----AIEFCTHINAQ 1127
|
90 100 110
....*....|....*....|....*....|.
gi 56678146 437 WAMPDSASRTQKAIRAVAEVGNPTIVA-TLT 466
Cdd:TIGR00917 1128 FSTGKHFSRNHRAKEALGGMGSSVFSGiTLT 1158
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
356-511 |
1.02e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 46.38 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 356 NELLFHLGLATVSIVVLVLFSI-GWRESIVVAVVIPVTILLTLFAAWVMGYTLNRVSLFALIFSIGILVDDAIVvienIA 434
Cdd:COG4258 639 NDALWLLLLALLLILLLLLLRLrSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF----FT 714
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56678146 435 RHWAMPDSASRTQKAIravaevgnptIVATLTVVAALlpmlfvsGLMGpyMSPIPANASAAMIFSF--FVAVIITPWLM 511
Cdd:COG4258 715 EGLLDKGELARTLLSI----------LLAALTTLLGF-------GLLA--FSSTPALRSFGLTVLLgiLLALLLAPLLA 774
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
915-1038 |
1.10e-04 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 46.39 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 915 RDMGAAFGVALLGIYILVVAQFGSFRLPLVVLTPVpltFLGIIIG---HWLFNAPFSAPSMIGFIALAGIIVRNSI-LLV 990
Cdd:COG1033 218 SDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVV---LLAVIWTlglMGLLGIPLSPLTILVPPLLLAIGIDYGIhLLN 294
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 56678146 991 DFIRHANPERDKIETLIEAGAIRFKPILLTAVAAMIG-AAVILTD-PIFQ 1038
Cdd:COG1033 295 RYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLFSDiPPIR 344
|
|
| PRK13024 |
PRK13024 |
bifunctional preprotein translocase subunit SecD/SecF; Reviewed |
362-517 |
1.58e-03 |
|
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
Pssm-ID: 237276 [Multi-domain] Cd Length: 755 Bit Score: 42.53 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 362 LGLATVSIVVLVLFSIGWRESI--VVAVVIPVTILLTLFAawVMGYTLNRVSLFALIFSIGILVDDAIVVIENIARHWAM 439
Cdd:PRK13024 583 VLIALIGILLYILIRFEWTFSLgaILALLHDVLIVIGFFS--LFRLEVDLTFIAAILTIIGYSINDTVVVFDRIRENLRL 660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 440 PDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSGlmgpymsPIPANASAAMIF--------SFFVAViitpWLM 511
Cdd:PRK13024 661 YKKKDLREIVNKSINQTLSRTINTSLTTLLVLLALLIFGG-------SSLRNFSLALLVglivgtysSIFIAA----PLW 729
|
....*.
gi 56678146 512 VKIAGR 517
Cdd:PRK13024 730 LDLEKR 735
|
|
| 2A0604s01 |
TIGR00916 |
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ... |
359-479 |
3.14e-03 |
|
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273336 [Multi-domain] Cd Length: 192 Bit Score: 39.93 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 359 LFHLGLATVSIVVLVLFSIGWRESI--VVAVVIPVTILLTLFAawVMGYTLNRVSLFALIFSIGILVDDAIVVIENIARH 436
Cdd:TIGR00916 50 IIALLIGLVLVLLYMLLRYEWRGAIaaIAALVHDVILILGVLS--LFGATLTLPGIAGLLTIIGYSVDDTVVIFDRIREE 127
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 56678146 437 WAMPDSASRTQKAIRAVAEVGNPTIVATLTVVAALLPMLFVSG 479
Cdd:TIGR00916 128 LRKYKGRTFREAINLGINQTLSRIIDTNVTTLLAVLALYVFGG 170
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
330-514 |
4.93e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 40.98 E-value: 4.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 330 LEHDLIPDSVEVTVTRDYGETAN---EKANELLFHLGLATVSIV-VLVLFSIGWRESIVVAVVIPVTILLTLFAAWVMGY 405
Cdd:TIGR00921 164 LERTNPPSGKFLDVTGSPAINYDierEFGKDMGTTMAISGILVVlVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGI 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56678146 406 TLNRVSLFALIFSIGILVDDAIVVIENIARHWAMPDSASrtQKAIRAVAEVGNPTIVATLTVVAALLPMlFVSGLmgPYM 485
Cdd:TIGR00921 244 PLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKG--EAIVTAVRRTGRAVLIALLTTSAGFAAL-ALSEF--PMV 318
|
170 180
....*....|....*....|....*....
gi 56678146 486 SPIPANASAAMIFSFFVAVIITPWLMVKI 514
Cdd:TIGR00921 319 SEFGLGLVAGLITAYLLTLLVLPALLQSI 347
|
|
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