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Conserved domains on  [gi|55375973|gb|AAV49999|]
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chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) [Homo sapiens]

Protein Classification

CXC family chemokine( domain architecture ID 10084510)

CXC family chemokine such as interleukin-8, also called C-X-C motif chemokine 8, that is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes, and is involved in neutrophil activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 27-88 6.25e-14

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


:

Pssm-ID: 238171  Cd Length: 64  Bit Score: 60.35  E-value: 6.25e-14
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55375973 27 SYRCPCRFFESH-VARANVKHLKIL-NTPNCA-LQIVARLKNNnRQVCIDPKLKWIQEYLEKALN 88
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIpPGPHCPnTEIIATLKNG-RKVCLNPEAPWVQKIIKKLLK 64
 
Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 27-88 6.25e-14

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238171  Cd Length: 64  Bit Score: 60.35  E-value: 6.25e-14
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55375973 27 SYRCPCRFFESH-VARANVKHLKIL-NTPNCA-LQIVARLKNNnRQVCIDPKLKWIQEYLEKALN 88
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIpPGPHCPnTEIIATLKNG-RKVCLNPEAPWVQKIIKKLLK 64
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 27-85 2.78e-08

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 46.08  E-value: 2.78e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55375973    27 SYRCpCRFFES-HVARANVKHLKIlNTPNCAL-QIVARLKNNnRQVCIDPKLKWIQEYLEK 85
Cdd:smart00199  1 PLRC-CLSYTSkKIPLKRIKSYYP-TSSHCPKpAVIFTTKKG-RKVCADPKAKWVQRYIKK 58
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 48-85 2.48e-04

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 35.71  E-value: 2.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55375973   48 KILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEK 85
Cdd:pfam00048 22 IQPASSSCPKPAVIFLTKKGRQVCADPKAKWVQRLIKK 59
 
Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 27-88 6.25e-14

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238171  Cd Length: 64  Bit Score: 60.35  E-value: 6.25e-14
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55375973 27 SYRCPCRFFESH-VARANVKHLKIL-NTPNCA-LQIVARLKNNnRQVCIDPKLKWIQEYLEKALN 88
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIpPGPHCPnTEIIATLKNG-RKVCLNPEAPWVQKIIKKLLK 64
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 31-87 4.39e-09

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 48.10  E-value: 4.39e-09
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55375973 31 PCRFFES-HVARANVKHLKILNT--PNCALQIVARLKNNnRQVCIDPKLKWIQEYLEKAL 87
Cdd:cd00169  1 CCLKYTSkPIPPKNIKSYRVQEAggHCSIPAVIFTTKKG-RKVCADPKEPWVKDLIQKLD 59
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 27-85 2.78e-08

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 46.08  E-value: 2.78e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55375973    27 SYRCpCRFFES-HVARANVKHLKIlNTPNCAL-QIVARLKNNnRQVCIDPKLKWIQEYLEK 85
Cdd:smart00199  1 PLRC-CLSYTSkKIPLKRIKSYYP-TSSHCPKpAVIFTTKKG-RKVCADPKAKWVQRYIKK 58
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 48-85 2.48e-04

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 35.71  E-value: 2.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55375973   48 KILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEK 85
Cdd:pfam00048 22 IQPASSSCPKPAVIFLTKKGRQVCADPKAKWVQRLIKK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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