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Conserved domains on  [gi|52548411|gb|AAU82260|]
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trehalose phosphorylase [uncultured archaeon GZfos12E2]

Protein Classification

GT1_Trehalose_phosphorylase domain-containing protein( domain architecture ID 10133391)

GT1_Trehalose_phosphorylase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 55-427 0e+00

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


:

Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 557.71  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  55 KMLELSSTPLGGGVAEMLHSSVPFLNSIGIDDEWKVIKGSKEFFEVTKTMHHLLQGKKGK-LTAEDEKIYFSAIKENVA- 132
Cdd:cd03792   1 KVAHFSSTPQGGGVAEILHALVPLMRELGLDVRWYVIKGRPEFFNITKKFHNILQGVDKPeLSEEDKEIYLEWIEENASr 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 133 LDIIDYEPDVVFVHDPQPLALARELKRGDVRWIWRCHIDIDEVALRRNPRLWDFITYWAEAFDAAIFTTAYFVISQWPLP 212
Cdd:cd03792  81 YPLLDGDADVVVIHDPQPALLPKIKKKRDRKWIWRCHIDISTPLTEPQPRVWDFLWNYIEGYDLFVFHPPEFVPPQVPPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 213 KFIIPPFIDPLSEKNREMSDDEIQKELEK-EDIDTEKPILSQISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGGFASD 290
Cdd:cd03792 161 KFYIPPSIDPLSGKNKDLSPADIRYYLEKpFVIDPERPYILQVARFDPSKDPLGVIDAYKLFKRRaEEPQLVICGHGAVD 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 291 DPEGERVYKELKETTRDDKNIHILCECP-DSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRD 369
Cdd:cd03792 241 DPEGSVVYEEVMEYAGDDHDIHVLRLPPsDQEINALQRAATVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVID 320

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 52548411 370 GHTGFLVNGEEEAVKRILHLLRDPKKRDVVGKRARRYVKEHFLLPVRIVDYLLAADFI 427
Cdd:cd03792 321 GETGFLVNSVEGAAVRILRLLTDPELRRKMGLAAREHVRDNFLITGNLRAWLYLIAKL 378
 
Name Accession Description Interval E-value
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 55-427 0e+00

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 557.71  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  55 KMLELSSTPLGGGVAEMLHSSVPFLNSIGIDDEWKVIKGSKEFFEVTKTMHHLLQGKKGK-LTAEDEKIYFSAIKENVA- 132
Cdd:cd03792   1 KVAHFSSTPQGGGVAEILHALVPLMRELGLDVRWYVIKGRPEFFNITKKFHNILQGVDKPeLSEEDKEIYLEWIEENASr 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 133 LDIIDYEPDVVFVHDPQPLALARELKRGDVRWIWRCHIDIDEVALRRNPRLWDFITYWAEAFDAAIFTTAYFVISQWPLP 212
Cdd:cd03792  81 YPLLDGDADVVVIHDPQPALLPKIKKKRDRKWIWRCHIDISTPLTEPQPRVWDFLWNYIEGYDLFVFHPPEFVPPQVPPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 213 KFIIPPFIDPLSEKNREMSDDEIQKELEK-EDIDTEKPILSQISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGGFASD 290
Cdd:cd03792 161 KFYIPPSIDPLSGKNKDLSPADIRYYLEKpFVIDPERPYILQVARFDPSKDPLGVIDAYKLFKRRaEEPQLVICGHGAVD 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 291 DPEGERVYKELKETTRDDKNIHILCECP-DSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRD 369
Cdd:cd03792 241 DPEGSVVYEEVMEYAGDDHDIHVLRLPPsDQEINALQRAATVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVID 320

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 52548411 370 GHTGFLVNGEEEAVKRILHLLRDPKKRDVVGKRARRYVKEHFLLPVRIVDYLLAADFI 427
Cdd:cd03792 321 GETGFLVNSVEGAAVRILRLLTDPELRRKMGLAAREHVRDNFLITGNLRAWLYLIAKL 378
TreT_Thcocales NF041139
trehalose synthase;
29-421 2.07e-116

trehalose synthase;


Pssm-ID: 469061 [Multi-domain]  Cd Length: 412  Bit Score: 347.21  E-value: 2.07e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   29 LKEYAKIVGEEPIKKLEEVSERLSGMKMLELSSTPLGGGVAEMLHSSVPFLNSIGIDDEWKVIKGSKEFFEVTKTMHHLL 108
Cdd:NF041139  14 LEDYKSIIGEEAIEKIKEKAEDLKGKSFVHVNSTSFGGGVAEILHNLVPLMRSLGIDARWFVIEGTDEFFNVTKTFHNAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  109 QGKKG-KLTAEDEKIYFSAIKENVA-LDIIDYepDVVFVHDPQPLALArELKRGDVRWIWRCHIDIDEvalrRNPRLWDF 186
Cdd:NF041139  94 QGNKElKLTEEMKDLYLETNKENAEnLDLSEF--DYVLIHDPQPAPLI-EFYEKRQPWIWRCHIDLSD----PNPEFWSF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  187 ITYWAEAFDAAIFTTAYFVISQWPLPKFII-PPFIDPLSEKNREMSDDEIQKELEKEDIDTEKPILSQISRFDHWKDPEG 265
Cdd:NF041139 167 LRRFVEKYDRYIFHMPEYVQKDLDKNKVVImPPSIDPLSEKNIELSDSEILKILERFDVDPDRPIITQVARFDPWKGVFD 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  266 VVSIYKKVKEK-EECQLILAGGFASDDPEGERVYKELKETTRDDKNIHILCE---CPDSCINAIQRASSVILQNSRKEGF 341
Cdd:NF041139 247 VIEVYRKVKEKiPDVQLLLVGVMAHDDPEGWIYFEKTLRKIGEDYDVKVLTNligVHAREVNAFQRASDVILQMSIREGF 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  342 GLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVNGEEEAVKRILHLLRDPKKRDVVGKRARRYVKEHFLLPVRIVDYL 421
Cdd:NF041139 327 GLTVTEAMWKGKPVIGRAVGGIKFQIVDGETGFLVRDVDEAVEKTLYLLKHPEVAKRMGIKAKERVKENFIITKHLERYL 406
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 247-405 1.13e-24

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 99.66  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   247 EKPILSQISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGgfasdDPEGERVYKELKETTRDDKNIHILCECPDSCINAI 325
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKnPNLKLVIAG-----DGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPEL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   326 QRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLV--NGEEEAVKRILHLLRDPKKRDVVGKRA 403
Cdd:pfam00534  76 LKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENA 155


                  ..
gi 52548411   404 RR 405
Cdd:pfam00534 156 RK 157
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 309-421 3.16e-24

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 96.98  E-value: 3.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 309 KNIHILcecpdscINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVNGE--EEAVKRI 386
Cdd:COG0438   8 KGLDLL-------LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGdpEALAEAI 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 52548411 387 LHLLRDPKKRDVVGKRARRYVKEHFLLPVRIVDYL 421
Cdd:COG0438  81 LRLLEDPELRRRLGEAARERAEERFSWEAIAERLL 115
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 336-409 2.14e-09

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 59.34  E-value: 2.14e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52548411  336 SRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRD---GHTGFLVN-GE-EEAVKRILHLLRDPKKRDVVGKRARRYVKE 409
Cdd:PLN02871 339 SESETLGFVVLEAMASGVPVVAARAGGIPDIIPPdqeGKTGFLYTpGDvDDCVEKLETLLADPELRERMGAAAREEVEK 417
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 274-358 2.78e-07

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 52.40  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   274 KEKEECQLILAGGFASDDPEG--ERVYKELKETTRDDKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWK 351
Cdd:TIGR04047 220 ARRPQAQLVIAGGATLFDYDAyrREFRARAAELGVDPGPVVITGPVPDADLPALYRCADAFAFPSLKEGFGLVVLEALAS 299


                  ....*..
gi 52548411   352 GKPVVAR 358
Cdd:TIGR04047 300 GIPVVAS 306
 
Name Accession Description Interval E-value
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 55-427 0e+00

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 557.71  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  55 KMLELSSTPLGGGVAEMLHSSVPFLNSIGIDDEWKVIKGSKEFFEVTKTMHHLLQGKKGK-LTAEDEKIYFSAIKENVA- 132
Cdd:cd03792   1 KVAHFSSTPQGGGVAEILHALVPLMRELGLDVRWYVIKGRPEFFNITKKFHNILQGVDKPeLSEEDKEIYLEWIEENASr 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 133 LDIIDYEPDVVFVHDPQPLALARELKRGDVRWIWRCHIDIDEVALRRNPRLWDFITYWAEAFDAAIFTTAYFVISQWPLP 212
Cdd:cd03792  81 YPLLDGDADVVVIHDPQPALLPKIKKKRDRKWIWRCHIDISTPLTEPQPRVWDFLWNYIEGYDLFVFHPPEFVPPQVPPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 213 KFIIPPFIDPLSEKNREMSDDEIQKELEK-EDIDTEKPILSQISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGGFASD 290
Cdd:cd03792 161 KFYIPPSIDPLSGKNKDLSPADIRYYLEKpFVIDPERPYILQVARFDPSKDPLGVIDAYKLFKRRaEEPQLVICGHGAVD 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 291 DPEGERVYKELKETTRDDKNIHILCECP-DSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRD 369
Cdd:cd03792 241 DPEGSVVYEEVMEYAGDDHDIHVLRLPPsDQEINALQRAATVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVID 320

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 52548411 370 GHTGFLVNGEEEAVKRILHLLRDPKKRDVVGKRARRYVKEHFLLPVRIVDYLLAADFI 427
Cdd:cd03792 321 GETGFLVNSVEGAAVRILRLLTDPELRRKMGLAAREHVRDNFLITGNLRAWLYLIAKL 378
TreT_Thcocales NF041139
trehalose synthase;
29-421 2.07e-116

trehalose synthase;


Pssm-ID: 469061 [Multi-domain]  Cd Length: 412  Bit Score: 347.21  E-value: 2.07e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   29 LKEYAKIVGEEPIKKLEEVSERLSGMKMLELSSTPLGGGVAEMLHSSVPFLNSIGIDDEWKVIKGSKEFFEVTKTMHHLL 108
Cdd:NF041139  14 LEDYKSIIGEEAIEKIKEKAEDLKGKSFVHVNSTSFGGGVAEILHNLVPLMRSLGIDARWFVIEGTDEFFNVTKTFHNAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  109 QGKKG-KLTAEDEKIYFSAIKENVA-LDIIDYepDVVFVHDPQPLALArELKRGDVRWIWRCHIDIDEvalrRNPRLWDF 186
Cdd:NF041139  94 QGNKElKLTEEMKDLYLETNKENAEnLDLSEF--DYVLIHDPQPAPLI-EFYEKRQPWIWRCHIDLSD----PNPEFWSF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  187 ITYWAEAFDAAIFTTAYFVISQWPLPKFII-PPFIDPLSEKNREMSDDEIQKELEKEDIDTEKPILSQISRFDHWKDPEG 265
Cdd:NF041139 167 LRRFVEKYDRYIFHMPEYVQKDLDKNKVVImPPSIDPLSEKNIELSDSEILKILERFDVDPDRPIITQVARFDPWKGVFD 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  266 VVSIYKKVKEK-EECQLILAGGFASDDPEGERVYKELKETTRDDKNIHILCE---CPDSCINAIQRASSVILQNSRKEGF 341
Cdd:NF041139 247 VIEVYRKVKEKiPDVQLLLVGVMAHDDPEGWIYFEKTLRKIGEDYDVKVLTNligVHAREVNAFQRASDVILQMSIREGF 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  342 GLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVNGEEEAVKRILHLLRDPKKRDVVGKRARRYVKEHFLLPVRIVDYL 421
Cdd:NF041139 327 GLTVTEAMWKGKPVIGRAVGGIKFQIVDGETGFLVRDVDEAVEKTLYLLKHPEVAKRMGIKAKERVKENFIITKHLERYL 406
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 126-417 6.16e-35

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 133.43  E-value: 6.16e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 126 AIKENVALDIIDYEPDVVFVHDPQPLALARELKRG-DVRWIWRCH---IDIDEVALRRNPRLWDFITYWAEAFDAAIFTT 201
Cdd:cd03801  69 RLLRELRPLLRLRKFDVVHAHGLLAALLAALLALLlGAPLVVTLHgaePGRLLLLLAAERRLLARAEALLRRADAVIAVS 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 202 AY---FVISQWPLPK---FIIPPFIDPlseknremsDDEIQKELEKEDIDTEKPILSQISRFDHWKDPEGVVSIYKKVKE 275
Cdd:cd03801 149 EAlrdELRALGGIPPekiVVIPNGVDL---------ERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLR 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 276 K-EECQLILAGGfasDDPEGERVykeLKETTRDDKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKP 354
Cdd:cd03801 220 RgPDVRLVIVGG---DGPLRAEL---EELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLP 293

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52548411 355 VVARPAGGIALQIRDGHTGFLVNGE--EEAVKRILHLLRDPKKRDVVGKRARRYVKEHFLLPVRI 417
Cdd:cd03801 294 VVATDVGGLPEVVEDGEGGLVVPPDdvEALADALLRLLADPELRARLGRAARERVAERFSWERVA 358
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 247-405 1.13e-24

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 99.66  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   247 EKPILSQISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGgfasdDPEGERVYKELKETTRDDKNIHILCECPDSCINAI 325
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKnPNLKLVIAG-----DGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPEL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   326 QRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLV--NGEEEAVKRILHLLRDPKKRDVVGKRA 403
Cdd:pfam00534  76 LKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENA 155


                  ..
gi 52548411   404 RR 405
Cdd:pfam00534 156 RK 157
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 309-421 3.16e-24

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 96.98  E-value: 3.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 309 KNIHILcecpdscINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVNGE--EEAVKRI 386
Cdd:COG0438   8 KGLDLL-------LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGdpEALAEAI 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 52548411 387 LHLLRDPKKRDVVGKRARRYVKEHFLLPVRIVDYL 421
Cdd:COG0438  81 LRLLEDPELRRRLGEAARERAEERFSWEAIAERLL 115
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 215-411 8.00e-23

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 99.62  E-value: 8.00e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 215 IIPPFIDPlsekNREMSDDEIQKELEKEDIDTEKPILSQISRFDHWKDPEGVVSIYKKVKE-KEECQLILAGGfaSDDPE 293
Cdd:cd03800 191 VVPPGVDL----ERFFPVDRAEARRARLLLPPDKPVVLALGRLDPRKGIDTLVRAFAQLPElRELANLVLVGG--PSDDP 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 294 GERVYKELKETTRDDKNI---HILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDG 370
Cdd:cd03800 265 LSMDREELAELAEELGLIdrvRFPGRVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDG 344

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 52548411 371 HTGFLVNG--EEEAVKRILHLLRDPKKRDVVGKRARRYVKEHF 411
Cdd:cd03800 345 RTGLLVDPhdPEALAAALRRLLDDPALWQRLSRAGLERARAHY 387
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 135-406 1.12e-19

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 89.72  E-value: 1.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 135 IIDYEPDVVFVHDPQPLALARELKRGDVRWIWRCHIDIDEVALRRNPRLWDFITYWaeafdaaiFTTAYFVISQW----- 209
Cdd:cd03811  79 LKRAKPDVVISFLGFATYIVAKLAAARSKVIAWIHSSLSKLYYLKKKLLLKLKLYK--------KADKIVCVSKGikedl 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 210 ----PLPK---FIIPPFIDPlsEKNREMSDDEIQKELEKEDIdtekpILSqISRFDHWKDPEGVVSIYKKVKEK-EECQL 281
Cdd:cd03811 151 irlgPSPPekiEVIYNPIDI--DRIRALAKEPILNEPEDGPV-----ILA-VGRLDPQKGHDLLIEAFAKLRKKyPDVKL 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 282 ILAGgfasddpEGERvYKELKETTRD---DKNIHILCECPDscINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVAR 358
Cdd:cd03811 223 VILG-------DGPL-REELEKLAKElglAERVIFLGFQSN--PYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVST 292

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 52548411 359 PAGGIALQIRDGHTGFLV-NGEEEAVKRILHLLRDPKKRDVVGKRARRY 406
Cdd:cd03811 293 DCPGPREILDDGENGLLVpDGDAAALAGILAALLQKKLDAALRERLAKA 341
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 241-411 1.37e-19

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 89.58  E-value: 1.37e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 241 KEDIDTEKPILSQISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGGFASDDPegervYKELKETTRDDKNIHILCECPD 319
Cdd:cd03808 182 PESLPSEKVVFLFVARLLKDKGIDELIEAAKILKKKgPNVRFLLVGDGELENP-----SEILIEKLGLEGRIEFLGFRSD 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 320 scINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVNG--EEEAVKRILHLLRDPKKRD 397
Cdd:cd03808 257 --VPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLVPPgdVEALADAIEKLIEDPELRK 334

                       170
                ....*....|....
gi 52548411 398 VVGKRARRYVKEHF 411
Cdd:cd03808 335 EMGEAARKRVEEKF 348
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 215-424 1.63e-17

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 83.56  E-value: 1.63e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 215 IIPPFIDpLSEKNREMSDDEIQKELEKEDidtEKpILSQISRFDHWKDPEGVVSIYKKVKEKEECQLILAGgfasDDPEG 294
Cdd:cd04962 168 VIHNFID-EDVFKRKPAGALKRRLLAPPD---EK-VVIHVSNFRPVKRIDDVVRVFARVRRKIPAKLLLVG----DGPER 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 295 ERVYKELKETTRDDKnIHILCECPdsCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGF 374
Cdd:cd04962 239 VPAEELARELGVEDR-VLFLGKQD--DVEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKHGETGF 315

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 52548411 375 LVN-GEEEAV-KRILHLLRDPKKRDVVGKRARRYVKEHFlLPVRIVDYLLAA 424
Cdd:cd04962 316 LSDvGDVDAMaKSALSILEDDELYNRMGRAARKRAAERF-DPERIVPQYEAY 366
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 212-410 7.95e-17

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 81.56  E-value: 7.95e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 212 PKFIIPPFIDPlsEKNREMSDDEIQKELEkedIDTEKPILSQISRFDHWKDPEGVVSIYKKVKEKEECQLILAGgfasDD 291
Cdd:cd03817 170 PIEVIPNGIDL--DKFEKPLNTEERRKLG---LPPDEPILLYVGRLAKEKNIDFLLRAFAELKKEPNIKLVIVG----DG 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 292 PEgERVYKELKETTRDDKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGH 371
Cdd:cd03817 241 PE-REELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELVEDGE 319

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 52548411 372 TGFLV-NGEEEAVKRILHLLRDPKKRDVVGKRARRYVKEH 410
Cdd:cd03817 320 NGFLFePNDETLAEKLLHLRENLELLRKLSKNAEISAREF 359
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 132-376 4.88e-16

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 77.06  E-value: 4.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 132 ALDIIDYEPDVVFVHDPQPLALA--RELKRGDVRWIWRCHIDIDEVALRRNPRlwdfitYWAEAFDAAIFTTAYFVisqw 209
Cdd:cd01635  47 LKKLLELKPDVVHAHSPHAAALAalLAARLLGIPIVVTVHGPDSLESTRSELL------ALARLLVSLPLADKVSV---- 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 210 plpkfiippfidplseknremsddeiqkelekedidtekpilsqiSRFDHWKDPEGVVSIYKKVKEKEEC-QLILAGgfa 288
Cdd:cd01635 117 ---------------------------------------------GRLVPEKGIDLLLEALALLKARLPDlVLVLVG--- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 289 sDDPEGERVYKELKETTRDDKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIR 368
Cdd:cd01635 149 -GGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVV 227


                ....*...
gi 52548411 369 DGHTGFLV 376
Cdd:cd01635 228 DGENGLLV 235
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 135-411 1.70e-15

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 77.74  E-value: 1.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 135 IIDYEPDVVFVHDPQPLALARELKRGD--VRWIW---RCHIDIDEVALRR--NPRLWDFITYW-AEAFDAAIFTTAYfvi 206
Cdd:cd03807  75 IRKRNPDVVHTWMYHADLIGGLAAKLAggVKVIWsvrSSNIPQRLTRLVRklCLLLSKFSPATvANSSAVAEFHQEQ--- 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 207 sQWPLPKFI-IPPFIDPLSEKNREMSDDEIQKELEkedIDTEKPILSQISRFDHWKDPEGVVSIYKKVKEK-EECQLILA 284
Cdd:cd03807 152 -GYAKNKIVvIYNGIDLFKLSPDDASRARARRRLG---LAEDRRVIGIVGRLHPVKDHSDLLRAAALLVEThPDLRLLLV 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 285 GgfasDDPEGERVYKELKETTRDDKnIHILCECPDscINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIA 364
Cdd:cd03807 228 G----RGPERPNLERLLLELGLEDR-VHLLGERSD--VPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAA 300

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 52548411 365 LQIRDGhTGFLV-NGEEEAVKR-ILHLLRDPKKRDVVGKRARRYVKEHF 411
Cdd:cd03807 301 ELVDDG-TGFLVpAGDPQALADaIRALLEDPEKRARLGRAARERIANEF 348
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 328-410 4.52e-14

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 73.10  E-value: 4.52e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 328 ASS-VILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVN-GEEEA-VKRILHLLRDPKKRDVVGKRAR 404
Cdd:cd03814 266 ASAdVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEpGDAAAfAAALRALLEDPELRRRMAARAR 345


                ....*.
gi 52548411 405 RYVKEH 410
Cdd:cd03814 346 AEAERY 351
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 133-424 3.21e-13

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 70.87  E-value: 3.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 133 LDIIDYEPDVVFVHD--PQPLALARELKRGDVRWIWRCH-IDIDEvaLRRNPRLWDFITYWAEAFDAAIFTTAYF---VI 206
Cdd:cd03798  89 KRRRRGPPDLIHAHFayPAGFAAALLARLYGVPYVVTEHgSDINV--FPPRSLLRKLLRWALRRAARVIAVSKALaeeLV 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 207 SQWPLPK--FIIPPFIDPlseKNREMSDDEIQKELEKedidteKPILSqISRFDHWKDPEGVVSIYKKV-KEKEECQLIL 283
Cdd:cd03798 167 ALGVPRDrvDVIPNGVDP---ARFQPEDRGLGLPLDA------FVILF-VGRLIPRKGIDLLLEAFARLaKARPDVVLLI 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 284 AGgfasDDPEGERVYKELKETTRDDkNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGI 363
Cdd:cd03798 237 VG----DGPLREALRALAEDLGLGD-RVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGI 311

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52548411 364 ALQIRDGHTGFLVN-GEEEAVKRIL-HLLRDPKKRDVVGKRARRYVKEHFllPVRIVDYLLAA 424
Cdd:cd03798 312 PEVVGDPETGLLVPpGDADALAAALrRALAEPYLRELGEAARARVAERFS--WVKAADRIAAA 372
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 234-411 3.70e-13

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 70.70  E-value: 3.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 234 EIQKELEKEDIDTEKPILSQISRFDHWKDPEGVVSIYKKVK----EKEECQLILAGGFASDDPEGERVYKEL----KETT 305
Cdd:cd03805 197 SEDPDPGDLIAKSNKKFFLSINRFERKKNIALAIEAFAKLKqklpEFENVRLVIAGGYDPRVAENVEYLEELqrlaEELL 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 306 RDDKNIHILCECPDScinaiQRASsvILQNSR-------KEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLV-- 376
Cdd:cd03805 277 NVEDQVLFLRSISDS-----QKEQ--LLSSALallytpsNEHFGIVPLEAMYAGKPVIACNSGGPLETVVEGVTGFLCep 349

                       170       180       190
                ....*....|....*....|....*....|....*
gi 52548411 377 NGEEEAVKrILHLLRDPKKRDVVGKRARRYVKEHF 411
Cdd:cd03805 350 TPEAFAEA-MLKLANDPDLADRMGAAGRKRVKEKF 383
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 237-405 6.37e-13

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 69.69  E-value: 6.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 237 KELEKEDIDTEKPILSQISRFDHWKDPEGVVSIYKKVKEKEECQLILAGgfasDDPEGERVYKELKETTRDDKnIHILCE 316
Cdd:cd03819 171 EERAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAAELKDEPDFRLLVAG----DGPERDEIRRLVERLGLRDR-VTFTGF 245

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 317 CPDscINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVN-GEEEAVKR-ILHLLRDPK 394
Cdd:cd03819 246 RED--VPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPpGDAEALADaIRAAKLLPE 323

                       170
                ....*....|.
gi 52548411 395 KRDVVGKRARR 405
Cdd:cd03819 324 AREKLQAAAAL 334
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
248-392 9.45e-13

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 65.23  E-value: 9.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   248 KPILSQISRFDHWKDpeGV---VSIYKKVKEKE-ECQLILAGgfasddpEGERvyKELKETTRD-DKNIHILCECPDscI 322
Cdd:pfam13692   1 RPVILFVGRLHPNVK--GVdylLEAVPLLRKRDnDVRLVIVG-------DGPE--EELEELAAGlEDRVIFTGFVED--L 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52548411   323 NAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIAlQIRDGHTGFLV-NGEEEA-VKRILHLLRD 392
Cdd:pfam13692  68 AELLAAADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIP-ELVDGENGLLVpPGDPEAlAEAILRLLED 138
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 197-421 3.57e-12

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 67.36  E-value: 3.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 197 AIFTTAYFVI---SQW------------PLPKFIIPPFIDPlseknremsddEIQKELEKED------IDTEKPILSQIS 255
Cdd:cd03825 132 EALAKKRLTIvapSRWladmvrrspllkGLPVVVIPNGIDT-----------EIFAPVDKAKarkrlgIPQDKKVILFGA 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 256 R--FDHWKDPEGVVSIYKKVKEKEECQLILAGGFASDDPEGERVYKELKETTrDDKNIHIlcecpdscinaIQRASSVIL 333
Cdd:cd03825 201 EsvTKPRKGFDELIEALKLLATKDDLLLVVFGKNDPQIVILPFDIISLGYID-DDEQLVD-----------IYSAADLFV 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 334 QNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLV-NGEEEAVKR-ILHLLRDPKKRDVVGKRARRYVKEHF 411
Cdd:cd03825 269 HPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVpPGDVQALAEaIEWLLANPKERESLGERARALAENHF 348

                       250
                ....*....|
gi 52548411 412 LLPVRIVDYL 421
Cdd:cd03825 349 DQRVQAQRYL 358
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 139-411 4.92e-12

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 67.01  E-value: 4.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 139 EPDVVFVHD---PQPLALARELKRGDVRWIWRCHIDIDEVALRRNPRLWDFITYWAE-----AFDAAIFTTAYFVISQWP 210
Cdd:cd03821  90 EYDVVHIHGvwtYTSLAACKLARRRGIPYVVSPHGMLDPWALQQKHWKKRIALHLIErrnlnNAALVHFTSEQEADELRR 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 211 L----PKFIIP-----PFIDPLSEKNREMSDDEiqkelekedidtEKPILSQISRFDHWKDPEGVVSIYKKVKEKE-ECQ 280
Cdd:cd03821 170 FglepPIAVIPngvdiPEFDPGLRDRRKHNGLE------------DRRIILFLGRIHPKKGLDLLIRAARKLAEQGrDWH 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 281 LILAGgfaSDDPEGERVYKELKETTRDDKnIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPA 360
Cdd:cd03821 238 LVIAG---PDDGAYPAFLQLQSSLGLGDR-VTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDK 313

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 52548411 361 GGIALQIRDGhTGFLVNGEEEAVKRIL-HLLRDPKKRDVVGKRARRYVK--EHF 411
Cdd:cd03821 314 CGLSELVEAG-CGVVVDPNVSSLAEALaEALRDPADRKRLGEMARRARQveENF 366
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 93-415 6.59e-12

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 66.49  E-value: 6.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  93 GSKEFFEVTKTMHHLLQGKKGKLTAEDEKIYFSAIKENVALdIIDYEPDVVFVHDPQPLALARELKRGDVRWIWrCHIDI 172
Cdd:cd03820  42 EKPPFYELDDNIKIKNLGDRKYSHFKLLLKYFKKVRRLRKY-LKNNKPDVVISFRTSLLTFLALIGLKSKLIVW-EHNNY 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 173 DEVaLRRNPRLWDFITYWAEAFDAAIFTTAYFVISQWPLPKFI--IPPFIDPLSEknremsddeiqkelEKEDIDTEKPI 250
Cdd:cd03820 120 EAY-NKGLRRLLLRRLLYKRADKIVVLTEADKLKKYKQPNSNVvvIPNPLSFPSE--------------EPSTNLKSKRI 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 251 LSqISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGgfasddpEGERvyKELKETTRDDKNI--HILCECPDSCINAIQR 327
Cdd:cd03820 185 LA-VGRLTYQKGFDLLIEAWALIAKKhPDWKLRIYG-------DGPE--REELEKLIDKLGLedRVKLLGPTKNIAEEYA 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 328 ASSVILQNSRKEGFGLTVTEAMWKGKPVVA--RPAgGIALQIRDGHTGFLVNGEEEA--VKRILHLLRDPKKRDVVGKRA 403
Cdd:cd03820 255 NSSIFVLSSRYEGFPMVLLEAMAYGLPIISfdCPT-GPSEIIEDGENGLLVPNGDVDalAEALLRLMEDEELRKKMGKNA 333

                       330
                ....*....|..
gi 52548411 404 rRYVKEHFLLPV 415
Cdd:cd03820 334 -RKNAERFSIEK 344
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 330-415 8.28e-12

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 66.32  E-value: 8.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 330 SVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLV-NGEEEAV-KRILHLLRDPKKRDVVGKRARRYV 407
Cdd:cd05844 270 SVTAASGDSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVpEGDVDALaDALQALLADRALADRMGGAARAFV 349


                ....*...
gi 52548411 408 KEHFLLPV 415
Cdd:cd05844 350 CEQFDIRV 357
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 138-421 1.22e-11

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 65.83  E-value: 1.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 138 YEPDVVFVHDPQPLA-----LARELKRG----DVRWIWRCH-IDIDEVALRRNPRLWDFIT-YWAEAFDAAIFTTAYFV- 205
Cdd:cd03794  97 ERPDVIIAYSPPITLglaalLLKKLRGApfilDVRDLWPESlIALGVLKKGSLLKLLKKLErKLYRLADAIIVLSPGLKe 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 206 -ISQWPLPK---FIIPPFIDPlsEKNREMSDDEIQKELEKEDidteKPILSQISRFDHWKDPEGVVSIYKKVKEKEECQL 281
Cdd:cd03794 177 yLLRKGVPKekiIVIPNWADL--EEFKPPPKDELRKKLGLDD----KFVVVYAGNIGKAQGLETLLEAAERLKRRPDIRF 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 282 ILAGGFasddPEGERVYKELKEttRDDKNIHILCECPDSCINAIQRASSVILQNSRKE-GFGLTV----TEAMWKGKPVV 356
Cdd:cd03794 251 LFVGDG----DEKERLKELAKA--RGLDNVTFLGRVPKEEVPELLSAADVGLVPLKDNpANRGSSpsklFEYMAAGKPIL 324

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52548411 357 ARPAGGIALQIRDGHTGFLVNGE--EEAVKRILHLLRDPKKRDVVGKRARRYVKEHFLLPVRIVDYL 421
Cdd:cd03794 325 ASDDGGSDLAVEINGCGLVVEPGdpEALADAILELLDDPELRRAMGENGRELAEEKFSREKLADRLL 391
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 339-411 4.79e-11

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 63.85  E-value: 4.79e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52548411 339 EGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVNGEEEAVKRILHLLR-DPKKrdvvgkrARRYVKEHF 411
Cdd:cd03802 251 EPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEEMAEAIANIDRiDRAA-------CRRYAEDRF 317
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 336-409 2.14e-09

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 59.34  E-value: 2.14e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52548411  336 SRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRD---GHTGFLVN-GE-EEAVKRILHLLRDPKKRDVVGKRARRYVKE 409
Cdd:PLN02871 339 SESETLGFVVLEAMASGVPVVAARAGGIPDIIPPdqeGKTGFLYTpGDvDDCVEKLETLLADPELRERMGAAAREEVEK 417
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
331-421 1.62e-08

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 51.84  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   331 VILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVNGEEEAVKRILHLLRDPKKRDVVGKRARRYVKEH 410
Cdd:pfam13524   2 VLNPSRRPDSPNMRVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIRYLLEHPEERRAIAAAGRERVLAE 81

                          90
                  ....*....|.
gi 52548411   411 FLLPVRIVDYL 421
Cdd:pfam13524  82 HTYAHRAEQLL 92
PLN00142 PLN00142
sucrose synthase
 212-384 6.81e-08

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 54.98  E-value: 6.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  212 PKF-IIPPFID-----PLSEKNREMSD--DEIQ-----KELEKEDI----DTEKPILSQISRFDHWKDPEGVVSIY-KKV 273
Cdd:PLN00142 520 PKFnIVSPGADmsiyfPYTEKQKRLTSlhPSIEellysPEQNDEHIgylkDRKKPIIFSMARLDRVKNLTGLVEWYgKNK 599

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  274 KEKEECQLILAGGF-----ASDDPEGERVYK--ELKETTRDDKNIHILCECPDSCINA-----IQRASSVILQNSRKEGF 341
Cdd:PLN00142 600 RLRELVNLVVVGGFidpskSKDREEIAEIKKmhSLIEKYNLKGQFRWIAAQTNRVRNGelyryIADTKGAFVQPALYEAF 679

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 52548411  342 GLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLV---NGEEEAVK 384
Cdd:PLN00142 680 GLTVVEAMTCGLPTFATCQGGPAEIIVDGVSGFHIdpyHGDEAANK 725
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 338-393 9.20e-08

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 53.87  E-value: 9.20e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 52548411 338 KEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLV--NGEEEAVKRILHLLRDP 393
Cdd:cd03823 271 PEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNGLLFapGDAEDLAAAMRRLLTDP 328
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 328-411 1.20e-07

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 53.61  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 328 ASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLV-NGEEEA-VKRILHLLRDPKKRDVVGKRARR 405
Cdd:cd03799 256 APSVTAADGDQDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVpERDAEAiAEKLTYLIEHPAIWPEMGKAGRA 335


                ....*.
gi 52548411 406 YVKEHF 411
Cdd:cd03799 336 RVEEEY 341
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 142-406 1.75e-07

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 53.14  E-value: 1.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 142 VVFVHDPQPLALaRELKRGDVRWIWRCHIDIdevALRRNprlwdfitywaeafdaaiftTAYFVISQW-----------P 210
Cdd:cd03809 105 VVTIHDLIPLRY-PEFFPKRFRLYYRLLLPI---SLRRA--------------------DAIITVSEAtrddiikfygvP 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 211 LPKF-IIPPFIDPlSEKNREMSDDEIQKELEKEDIdtekpILSqISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGGfa 288
Cdd:cd03809 161 PEKIvVIPLGVDP-SFFPPESAAVLIAKYLLPEPY-----FLY-VGTLEPRKNHERLLKAFALLKKQgGDLKLVIVGG-- 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 289 sDDPEGERVYKELKETtRDDKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGgiALQIR 368
Cdd:cd03809 232 -KGWEDEELLDLVKKL-GLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNIS--VLPEV 307

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 52548411 369 DGHTGFLVNGE--EEAVKRILHLLRDPKKRD---VVG-KRARRY 406
Cdd:cd03809 308 AGDAALYFDPLdpESIADAILRLLEDPSLREeliRKGlERAKKF 351
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 274-358 2.78e-07

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 52.40  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411   274 KEKEECQLILAGGFASDDPEG--ERVYKELKETTRDDKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWK 351
Cdd:TIGR04047 220 ARRPQAQLVIAGGATLFDYDAyrREFRARAAELGVDPGPVVITGPVPDADLPALYRCADAFAFPSLKEGFGLVVLEALAS 299


                  ....*..
gi 52548411   352 GKPVVAR 358
Cdd:TIGR04047 300 GIPVVAS 306
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 337-411 2.99e-07

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 52.28  E-value: 2.99e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52548411 337 RKEGFGLTVTEAMWKGKPVVAR--PAGGIALQIrDGHTGFLV-NGEEEAV-KRILHLLRDPKKRDVVGKRARRYVKEHF 411
Cdd:cd03795 272 RSEAFGIVLLEAMMCGKPVISTniGTGVPYVNN-NGETGLVVpPKDPDALaEAIDKLLSDEELRESYGENAKKRFEELF 349
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 237-408 7.22e-07

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 51.41  E-value: 7.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 237 KELEKE---DIDTEKPILSQISRFDHWKdpeGV---VSIYKKVKEkEECQLILAGgfaSDDPEGERVYKELKETTRDDKN 310
Cdd:cd03791 280 AALQKElglPVDPDAPLFGFVGRLTEQK---GVdliLDALPELLE-EGGQLVVLG---SGDPEYEQAFRELAERYPGKVA 352

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 311 IHILCECPDS-CINAiqrASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGH------TGFLVNGEE--- 380
Cdd:cd03791 353 VVIGFDEALAhRIYA---GADFFLMPSRFEPCGLVQMYAMRYGTLPIVRRTGGLADTVFDYDpetgegTGFVFEDYDaea 429

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 52548411 381 --EAVKRILHLLRDPKKRDVV-----------GKRARRYVK 408
Cdd:cd03791 430 llAALRRALALYRNPELWRKLqknamkqdfswDKSAKEYLE 470
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 214-411 4.21e-06

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 48.87  E-value: 4.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 214 FIIPPFIDPlseknremsddEIQKELEKEDIDTEKPILSQISRFDHWKDPEGVVSIYKKVKEKE-ECQLILAGGfasdDP 292
Cdd:cd03813 270 RVIPNGIDI-----------QRFAPAREERPEKEPPVVGLVGRVVPIKDVKTFIRAFKLVRRAMpDAEGWLIGP----ED 334

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 293 EGERVYKELKETTR--DDKNiHILCECPDSCINAIQRASSVILqNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRD- 369
Cdd:cd03813 335 EDPEYAQECKRLVAslGLEN-KVKFLGFQNIKEYYPKLGLLVL-TSISEGQPLVILEAMASGVPVVATDVGSCRELIYGa 412

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 52548411 370 ----GHTGFLVN-GEEEAV-KRILHLLRDPKKRDVVGKRARRYVKEHF 411
Cdd:cd03813 413 ddalGQAGLVVPpADPEALaEALIKLLRDPELRQAFGEAGRKRVEKYY 460
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 254-410 6.36e-06

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 48.07  E-value: 6.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 254 ISRFDHWKDPEGVVSIYKKVKEK-EECQLILAGgFASDdpegERVYKELKETTRDDKNIHIlcECPDSCINAIQRASSVI 332
Cdd:cd04949 166 ISRLAPEKQLDHLIEAVAKAVKKvPEITLDIYG-YGEE----REKLKKLIEELHLEDNVFL--KGYHSNLDQEYQDAYLS 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 333 LQNSRKEGFGLTVTEAMWKGKPVVA-RPAGGIALQIRDGHTGFLV--NGEEEAVKRILHLLRDPKKRDVVG----KRARR 405
Cdd:cd04949 239 LLTSQMEGFGLTLMEAIGHGLPVVSyDVKYGPSELIEDGENGYLIekNNIDALADKIIELLNDPEKLQQFSeesyKIAEK 318


                ....*
gi 52548411 406 YVKEH 410
Cdd:cd04949 319 YSTEN 323
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
 237-411 3.99e-05

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 45.68  E-value: 3.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 237 KELEKEDID--TEKPILSQISRFDHWKDPEGVVSIYKKVKEK------EECQLILAGGFASDDPEgERVY--KELKETTR 306
Cdd:cd03806 224 EELTKLPIDekTRENQILSIAQFRPEKNHPLQLRAFAELLKRlpesirSNPKLVLIGSCRNEEDK-ERVEalKLLAKELI 302

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 307 DDKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGG----IALQIRDGHTGFLVNGEEEA 382
Cdd:cd03806 303 LEDSVEFVVDAPYEELKELLSTASIGLHTMWNEHFGIGVVEYMAAGLIPLAHASAGplldIVVPWDGGPTGFLASTPEEY 382

                       170       180
                ....*....|....*....|....*....
gi 52548411 383 VKRILHLLRDPKKRDVVGKRARRYVKEHF 411
Cdd:cd03806 383 AEAIEKILTLSEEERLQRREAARSSAERF 411
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 201-411 5.24e-05

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 45.13  E-value: 5.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 201 TAYFvISQWPLPK---FIIPPFIDPLSEKNREMSDDEIQKELEKEDidTEKPILSqISRFDHWKD-PEGVVSIYKKVKEK 276
Cdd:cd04951 142 LDEF-IAKKAFSKnksVPVYNGIDLNKFKKDINVRLKIRNKLNLKN--DEFVILN-VGRLTEAKDyPNLLLAISELILSK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 277 EECQLILAGgfasddpEGErVYKELKETTRDDKNIH-ILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPV 355
Cdd:cd04951 218 NDFKLLIAG-------DGP-LRNELERLICNLNLVDrVILLGQISNISEYYNAADLFVLSSEWEGFGLVVAEAMACERPV 289

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 52548411 356 VARPAGGIALQIRDGHtgFLV---NGEEEAVKRILHLLRDPKKRDVVGKRaRRYVKEHF 411
Cdd:cd04951 290 VATDAGGVAEVVGDHN--YVVpvsDPQLLAEKIKEIFDMSDEERDILGNK-NEYIAKNF 345
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 301-413 5.86e-05

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 45.05  E-value: 5.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 301 LKETTRDDKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVN--G 378
Cdd:cd03818 273 LAELGVDLERVHFVGKVPYDQYVRLLQLSDAHVYLTYPFVLSWSLLEAMACGCPVIGSDTAPVREVIRDGRNGLLVDffD 352

                        90       100       110
                ....*....|....*....|....*....|....*
gi 52548411 379 EEEAVKRILHLLRDPKKRDVVGKRARRYVKEHFLL 413
Cdd:cd03818 353 PDALAAAVLELLEDPDRAAALRRAARRTVERSDSL 387
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
328-412 7.44e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 44.78  E-value: 7.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411  328 ASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFLVN---GEEEAVKRILHLLRDPkKRDVVGKRAR 404
Cdd:PRK15484 277 ADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAepmTSDSIISDINRTLADP-ELTQIAEQAK 355


                 ....*...
gi 52548411  405 RYVKEHFL 412
Cdd:PRK15484 356 DFVFSKYS 363
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
138-410 1.94e-04

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 43.38  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 138 YEPDVVFVHDPQPLaLARELKRGDVRWIWrchiDIDevalrrNPRLWDFITYWAEAFDAaifttaYFVISQWPLPKFiip 217
Cdd:COG4641  48 FRPDLVLVISGVEL-VAALRARGIPTVFW----DTD------DPVTLDRFRELLPLYDL------VFTFDGDCVEEY--- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 218 pfidplseknREMSddeiqkelekedidtekpilsqISRFDHWkdPEGV-VSIYKKVKE--KEECQLILAGGFasdDPEG 294
Cdd:COG4641 108 ----------RALG----------------------ARRVFYL--PFAAdPELHRPVPPeaRFRYDVAFVGNY---YPDR 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 295 ERVYKELKETTRD---------------DKNIHILCECPDSCINAIQRASSVILQNSRKEGFGLTVT----EAMWKGKPV 355
Cdd:COG4641 151 RARLEELLLAPAGlrlkiygpgwpklalPANVRRGGHLPGEEHPAAYASSKITLNVNRMAASPDSPTrrtfEAAACGAFL 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52548411 356 VARPAGGIALQIRDGHTGFLVNGEEEAVKRILHLLRDPKKRDVVGKRARRYV-KEH 410
Cdd:COG4641 231 LSDPWEGLEELFEPGEEVLVFRDGEELAEKLRYLLADPEERRAIAEAGRRRVlAEH 286
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 339-416 4.48e-04

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 42.27  E-value: 4.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 339 EGFGLTVTEAMWKGKPVVARPAGGIALQIRDGHTGFL-----VNGEEEAVKRILHlLRDPKKRDVVGKRARRYVKEHFLL 413
Cdd:cd03804 275 EDFGIVPVEAQACGTPVIAFGKGGALETVRPGPTGILfgeqtVESLKAAVEEFEQ-NFDRFKPQAIRANAERFSRARFRQ 353


                ...
gi 52548411 414 PVR 416
Cdd:cd03804 354 EIR 356
PLN02949 PLN02949
transferase, transferring glycosyl groups
 339-405 1.02e-03

transferase, transferring glycosyl groups


Pssm-ID: 215511 [Multi-domain]  Cd Length: 463  Bit Score: 41.26  E-value: 1.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52548411  339 EGFGLTVTEAMWKGKPVVARPAGGIALQI---RDGH-TGFLVNGEEEAVKRILHLLRDPK-KRDVVGKRARR 405
Cdd:PLN02949 365 EHFGISVVEYMAAGAVPIAHNSAGPKMDIvldEDGQqTGFLATTVEEYADAILEVLRMREtERLEIAAAARK 436
GT28_Beta-DGS-like cd17507
beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol ...
 295-423 1.29e-03

beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol synthase (processive diacylglycerol beta-glucosyltransferase EC 2.4.1.315) is involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. This family of glycosyltransferases also contains plant major galactolipid synthase (chloroplastic monogalactosyldiacylglycerol synthase 1 EC 2.4.1.46). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340861 [Multi-domain]  Cd Length: 364  Bit Score: 40.76  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 295 ERVYKELKETTRDDKNIHILCECPDscINAIQRASSVILQnsrKEGfGLTVTEAMWKGKPVVA-RPAG------------ 361
Cdd:cd17507 236 KKLYEKLSGLEEDYINVRVLGYVDD--MNELMAASDLVIT---KPG-GLTISEALARGLPVIIyDPIPgqeeenadflen 309

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52548411 362 -GIALQIRDghtgflvngeEEAVKRILHLLRDPKKRDVVGKRARRYVKEHFlLPVRIVDYLLA 423
Cdd:cd17507 310 nGAGIIARD----------PEELLEIVARLIDPPSLLRMMSEAAKELKPPA-AAKVIADILSL 361
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 292-411 1.58e-03

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 40.52  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52548411 292 PEGERVyKELKETTRDDKNIHILCECPDSCINAI--QRASSVILQNSRKEGFGLTVTEAMWKGKPVVARPAGGIALQIRD 369
Cdd:cd04946 267 PLKERL-EKLAENKLENVKVNFTGEVSNKEVKQLykENDVDVFVNVSESEGIPVSIMEAISFGIPVIATNVGGTREIVEN 345

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 52548411 370 GHTGFLVNGE---EEAVKRILHLLRDPKKRDVVGKRARRYVKEHF 411
Cdd:cd04946 346 ETNGLLLDKDptpNEIVSSIMKFYLDGGDYKTMKISARECWEERF 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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