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Conserved domains on  [gi|14972655|gb|AAK75284|]
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conserved domain protein [Streptococcus pneumoniae TIGR4]

Protein Classification

pneumococcal-type histidine triad protein( domain architecture ID 12854864)

pneumococcal-type histidine triad protein may bind metal cations such as Zn2+

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
strep_his_triad TIGR01363
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 1-334 0e+00

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


:

Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 592.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655     1 MILSVCSYELGLYQARTVKENNRVSYIDGKQATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVP 80
Cdd:TIGR01363  15 LLLSVCSYELGKYQAGSAKEDNRVAYIDGSQAKQKKENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655    81 YDAIISEELLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHSQHREGGTPRNDGAV 160
Cdd:TIGR01363  95 YDAIISEELLMKDPNYRLKDSDIVNEIKGGYVIKVNGKYYVYLKDAAHADNIRTKEEIARQKQEGSKEAKEKSKREDAAV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   161 ALARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAFLSGRGNLSNSRTYRRQNSDNTSR 240
Cdd:TIGR01363 175 AEARRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAYWSGKQGRGARPSDYRQGSRKASI 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   241 TNWVPSVSNPGTTNTNTSNNSNTNSQASQSNDIDSLLKQLYKLPLSQRHVESDGLVFDPAQITSRTARGVAVPHGDHYHF 320
Cdd:TIGR01363 255 PDVTPNPGQPAPPRPNDASQNKTQRQEFQGKTIKSLLDQLYRLPLSYRHVESDGLIFDPAQITSRTARGVAVPHGDHYHF 334

                         330
                  ....*....|....
gi 14972655   321 IPYSQMSELEERIA 334
Cdd:TIGR01363 335 IPYSQMSELEMRIA 348
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 531-581 1.52e-21

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


:

Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 88.17  E-value: 1.52e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 14972655   531 TTSDGYIFDEHDIISDEGDAYVTPHMGHSHWIGKDSLSDKEKVAAQAYTKE 581
Cdd:pfam04270   1 TTDDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKDDLSDEELAAAQAYLAG 51
strep_his_triad super family cl36882
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 521-649 1.60e-14

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


The actual alignment was detected with superfamily member TIGR01363:

Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 75.76  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   521 VRIAQLADKYTTSDGYIFDEHDIISDEGDAYVTPHMGHSHWIGKDSLSDKEKVAAQAYTKEKGILP-----------PSP 589
Cdd:TIGR01363 174 VAEARRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAYWSGKQGRGarpsdyrqgsrKAS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   590 DADVKANP-------TGDSAAAIYNR--VKGEKRIPLV----RLPYMVEHtveVKNGNLI---------------IPHKD 641
Cdd:TIGR01363 254 IPDVTPNPgqpapprPNDASQNKTQRqeFQGKTIKSLLdqlyRLPLSYRH---VESDGLIfdpaqitsrtargvaVPHGD 330


                  ....*...
gi 14972655   642 HYHNIKFA 649
Cdd:TIGR01363 331 HYHFIPYS 338
 
Name Accession Description Interval E-value
strep_his_triad TIGR01363
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 1-334 0e+00

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 592.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655     1 MILSVCSYELGLYQARTVKENNRVSYIDGKQATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVP 80
Cdd:TIGR01363  15 LLLSVCSYELGKYQAGSAKEDNRVAYIDGSQAKQKKENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655    81 YDAIISEELLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHSQHREGGTPRNDGAV 160
Cdd:TIGR01363  95 YDAIISEELLMKDPNYRLKDSDIVNEIKGGYVIKVNGKYYVYLKDAAHADNIRTKEEIARQKQEGSKEAKEKSKREDAAV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   161 ALARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAFLSGRGNLSNSRTYRRQNSDNTSR 240
Cdd:TIGR01363 175 AEARRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAYWSGKQGRGARPSDYRQGSRKASI 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   241 TNWVPSVSNPGTTNTNTSNNSNTNSQASQSNDIDSLLKQLYKLPLSQRHVESDGLVFDPAQITSRTARGVAVPHGDHYHF 320
Cdd:TIGR01363 255 PDVTPNPGQPAPPRPNDASQNKTQRQEFQGKTIKSLLDQLYRLPLSYRHVESDGLIFDPAQITSRTARGVAVPHGDHYHF 334

                         330
                  ....*....|....
gi 14972655   321 IPYSQMSELEERIA 334
Cdd:TIGR01363 335 IPYSQMSELEMRIA 348
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 531-581 1.52e-21

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 88.17  E-value: 1.52e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 14972655   531 TTSDGYIFDEHDIISDEGDAYVTPHMGHSHWIGKDSLSDKEKVAAQAYTKE 581
Cdd:pfam04270   1 TTDDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKDDLSDEELAAAQAYLAG 51
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 170-204 3.85e-16

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 72.76  E-value: 3.85e-16
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 14972655   170 TTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKN 204
Cdd:pfam04270   1 TTDDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKD 35
strep_his_triad TIGR01363
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 521-649 1.60e-14

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 75.76  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   521 VRIAQLADKYTTSDGYIFDEHDIISDEGDAYVTPHMGHSHWIGKDSLSDKEKVAAQAYTKEKGILP-----------PSP 589
Cdd:TIGR01363 174 VAEARRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAYWSGKQGRGarpsdyrqgsrKAS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   590 DADVKANP-------TGDSAAAIYNR--VKGEKRIPLV----RLPYMVEHtveVKNGNLI---------------IPHKD 641
Cdd:TIGR01363 254 IPDVTPNPgqpapprPNDASQNKTQRqeFQGKTIKSLLdqlyRLPLSYRH---VESDGLIfdpaqitsrtargvaVPHGD 330


                  ....*...
gi 14972655   642 HYHNIKFA 649
Cdd:TIGR01363 331 HYHFIPYS 338
 
Name Accession Description Interval E-value
strep_his_triad TIGR01363
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 1-334 0e+00

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 592.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655     1 MILSVCSYELGLYQARTVKENNRVSYIDGKQATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVP 80
Cdd:TIGR01363  15 LLLSVCSYELGKYQAGSAKEDNRVAYIDGSQAKQKKENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655    81 YDAIISEELLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHSQHREGGTPRNDGAV 160
Cdd:TIGR01363  95 YDAIISEELLMKDPNYRLKDSDIVNEIKGGYVIKVNGKYYVYLKDAAHADNIRTKEEIARQKQEGSKEAKEKSKREDAAV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   161 ALARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAFLSGRGNLSNSRTYRRQNSDNTSR 240
Cdd:TIGR01363 175 AEARRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAYWSGKQGRGARPSDYRQGSRKASI 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   241 TNWVPSVSNPGTTNTNTSNNSNTNSQASQSNDIDSLLKQLYKLPLSQRHVESDGLVFDPAQITSRTARGVAVPHGDHYHF 320
Cdd:TIGR01363 255 PDVTPNPGQPAPPRPNDASQNKTQRQEFQGKTIKSLLDQLYRLPLSYRHVESDGLIFDPAQITSRTARGVAVPHGDHYHF 334

                         330
                  ....*....|....
gi 14972655   321 IPYSQMSELEERIA 334
Cdd:TIGR01363 335 IPYSQMSELEMRIA 348
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 531-581 1.52e-21

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 88.17  E-value: 1.52e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 14972655   531 TTSDGYIFDEHDIISDEGDAYVTPHMGHSHWIGKDSLSDKEKVAAQAYTKE 581
Cdd:pfam04270   1 TTDDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKDDLSDEELAAAQAYLAG 51
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 170-204 3.85e-16

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 72.76  E-value: 3.85e-16
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 14972655   170 TTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKN 204
Cdd:pfam04270   1 TTDDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKD 35
strep_his_triad TIGR01363
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 521-649 1.60e-14

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 75.76  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   521 VRIAQLADKYTTSDGYIFDEHDIISDEGDAYVTPHMGHSHWIGKDSLSDKEKVAAQAYTKEKGILP-----------PSP 589
Cdd:TIGR01363 174 VAEARRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAYWSGKQGRGarpsdyrqgsrKAS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14972655   590 DADVKANP-------TGDSAAAIYNR--VKGEKRIPLV----RLPYMVEHtveVKNGNLI---------------IPHKD 641
Cdd:TIGR01363 254 IPDVTPNPgqpapprPNDASQNKTQRqeFQGKTIKSLLdqlyRLPLSYRH---VESDGLIfdpaqitsrtargvaVPHGD 330


                  ....*...
gi 14972655   642 HYHNIKFA 649
Cdd:TIGR01363 331 HYHFIPYS 338
PHtD_u1 pfam16645
Unstructured region on Pneumococcal histidine triad protein; PHtD_u1 is a natively ...
 223-288 1.56e-13

Unstructured region on Pneumococcal histidine triad protein; PHtD_u1 is a natively unstructured region on Pneumococcal histidine triad proteins of higher eukaryotes lying between the first two Strep_his_triad domains so far identified, pfam04270. The function is not known but it does not carry the characteriztic histidine triad.


Pssm-ID: 318786  Cd Length: 56  Bit Score: 65.58  E-value: 1.56e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14972655   223 NLSNSRTYrrqnsdNTSRTNWVPSvsNPgtTNTNTSNNSNTNSQASQSNDIDSLLKQLYKLPLSQR 288
Cdd:pfam16645   1 NLSNSRTY------NTSSTNWVPS--QP--TNTNTSNNSNTNSQPSQGEDIDSLLKQLYKLPLSQR 56
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 292-335 3.22e-11

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 58.90  E-value: 3.22e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 14972655   292 SDGLVFDPAQITSRTARGVAVPHGDHYHFIPYSQMSELEERIAR 335
Cdd:pfam04270   3 DDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKDDLSDEELAAAQ 46
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 56-89 6.31e-03

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 35.40  E-value: 6.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 14972655    56 VIKITDQGYVTSHGDHYHYyngkVPYDAIISEEL 89
Cdd:pfam04270  13 IIDDDGDGYITPHGDHFHY----IPKDDLSDEEL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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