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Conserved domains on  [gi|13447791|gb|AAK26753|]
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NOD26-like membrane integral protein ZmNIP3-1 [Zea mays]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 1-302 7.42e-170

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member PLN00026:

Pssm-ID: 444743 [Multi-domain]  Cd Length: 298  Bit Score: 472.42  E-value: 7.42e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791    1 MEPGSTPPNGSAPATPGTP-APLFssGGPRVDSLSY-ERKSMPRCKCLPLPAVEgWGvATHTCVVEIPAPDVSLTRKLGA 78
Cdd:PLN00026   1 MDNEEVPSAPSTPATPGTPgGPLF--GGFRVDSLSYgDRKLLPSCKCFPVEALE-WG-RLPTCFCDLPPPDVSLTRKLGA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   79 EFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVPAYVAVQ 158
Cdd:PLN00026  77 EFVGTFILIFAATAGPIVNQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYIAAQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  159 ALASVCAAFALKGVFHPFLSGGVTVPdaTVSTAQAFFTEFIISFNLLFVVTAVATDTRAVGELAGIAVGAAVTLNILVAG 238
Cdd:PLN00026 157 VSASICASFALKGVFHPFMSGGVTVP--SVSTGQAFALEFIITFNLLFVVTAVATDTRAVGELAGIAVGATVMLNILVAG 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13447791  239 PTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVYKAVKLRDENGETPRTQRSFRR 302
Cdd:PLN00026 235 PSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREEDGDPPRPVRSFRR 298
 
Name Accession Description Interval E-value
PLN00026 PLN00026
aquaporin NIP; Provisional
 1-302 7.42e-170

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 472.42  E-value: 7.42e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791    1 MEPGSTPPNGSAPATPGTP-APLFssGGPRVDSLSY-ERKSMPRCKCLPLPAVEgWGvATHTCVVEIPAPDVSLTRKLGA 78
Cdd:PLN00026   1 MDNEEVPSAPSTPATPGTPgGPLF--GGFRVDSLSYgDRKLLPSCKCFPVEALE-WG-RLPTCFCDLPPPDVSLTRKLGA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   79 EFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVPAYVAVQ 158
Cdd:PLN00026  77 EFVGTFILIFAATAGPIVNQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYIAAQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  159 ALASVCAAFALKGVFHPFLSGGVTVPdaTVSTAQAFFTEFIISFNLLFVVTAVATDTRAVGELAGIAVGAAVTLNILVAG 238
Cdd:PLN00026 157 VSASICASFALKGVFHPFMSGGVTVP--SVSTGQAFALEFIITFNLLFVVTAVATDTRAVGELAGIAVGATVMLNILVAG 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13447791  239 PTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVYKAVKLRDENGETPRTQRSFRR 302
Cdd:PLN00026 235 PSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREEDGDPPRPVRSFRR 298
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 71-284 8.15e-59

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 188.03  E-value: 8.15e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  71 SLTRKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQ 150
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791 151 VPAYVAVQALASVCAAFALKGVFHP--------FLSGGV--TVPDATVSTAQAFFTEFIISFNLLFVVTAVATDTRAVGE 220
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGhfdatedgGAKLGVfaTSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791 221 LAGIAVGAAVTLNILVAGPTTGGSMNPVRTLGPAVAA------GNYRQLWIYLLAPTLGALAGASVYKAV 284
Cdd:COG0580 161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRAL 230
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 74-282 4.57e-53

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 173.21  E-value: 4.57e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  74 RKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACA-GLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVP 152
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAwGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791 153 AYVAVQALASVCAAFALKGVF-----------HPFLSGGVTVPDATVSTAQAFFTEFIISFNLLFVVTAVATDTR--AVG 219
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYyglyleflganNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNgpPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13447791 220 ELAGIAVGAAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYR---QLWIYLLAPTLGALAGASVYK 282
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYD 226
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 70-281 2.22e-50

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 165.95  E-value: 2.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791    70 VSLTRKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACA---GLAVATVILSTGHISGAHLNPSLTIAFAALRHF 146
Cdd:pfam00230   5 VSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVAlafGLALATLVYCAGHISGAHLNPAVTLALLVGRRF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   147 PWLQVPAYVAVQALASVCAAFALKGVFHPFL--SGGVTVPDATVSTAQAFFTEFIISFNLLFVVTAVATDTRAV--GELA 222
Cdd:pfam00230  85 SLLRAIFYIVAQLLGAIAGAALLYGVTVGLQraGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGslGTVA 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13447791   223 GIAVGAAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVY 281
Cdd:pfam00230 165 PLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 78-281 3.97e-47

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 157.46  E-value: 3.97e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791    78 AEFVGTFILIFFA--TAAPIVNQKYGGAISPFGNAACA---GLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVP 152
Cdd:TIGR00861   1 AEFLGTFLLVFFGvgSALGVNVAGAYGAVGGGQFLGVAlafGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   153 AYVAVQALASVCAAFALKGVFHPFLSGG---VTVPDATVSTAQAFFTEFIISFNLLFVVTAVATDTRAV--GELAGIAVG 227
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNlavNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVprGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 13447791   228 AAVTLNILVAGPTTGGSMNPVRTLGPAVAAG--NYRQLWIYLLAPTLGALAGASVY 281
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
 
Name Accession Description Interval E-value
PLN00026 PLN00026
aquaporin NIP; Provisional
 1-302 7.42e-170

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 472.42  E-value: 7.42e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791    1 MEPGSTPPNGSAPATPGTP-APLFssGGPRVDSLSY-ERKSMPRCKCLPLPAVEgWGvATHTCVVEIPAPDVSLTRKLGA 78
Cdd:PLN00026   1 MDNEEVPSAPSTPATPGTPgGPLF--GGFRVDSLSYgDRKLLPSCKCFPVEALE-WG-RLPTCFCDLPPPDVSLTRKLGA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   79 EFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVPAYVAVQ 158
Cdd:PLN00026  77 EFVGTFILIFAATAGPIVNQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYIAAQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  159 ALASVCAAFALKGVFHPFLSGGVTVPdaTVSTAQAFFTEFIISFNLLFVVTAVATDTRAVGELAGIAVGAAVTLNILVAG 238
Cdd:PLN00026 157 VSASICASFALKGVFHPFMSGGVTVP--SVSTGQAFALEFIITFNLLFVVTAVATDTRAVGELAGIAVGATVMLNILVAG 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13447791  239 PTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVYKAVKLRDENGETPRTQRSFRR 302
Cdd:PLN00026 235 PSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREEDGDPPRPVRSFRR 298
PLN00184 PLN00184
aquaporin NIP1; Provisional
 70-289 7.34e-65

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 205.64  E-value: 7.34e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   70 VSLTRKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWL 149
Cdd:PLN00184  51 VPFLQKLIAEVLGTYFLVFTGCASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  150 QVPAYVAVQALASVCAAFALKGVF---HPFLSGGVTVPDATV---STAQAFFTEFIISFNLLFVVTAVATDTRAVGELAG 223
Cdd:PLN00184 131 QVPAYVISQVIGSTLAAATLRLLFgldHDVCSGKHDVFIGSSpvgSDLQAFVMEFIVTFYLMFIISGVATDNRAIGELAG 210

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13447791  224 IAVGAAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVYKAVKLRDE 289
Cdd:PLN00184 211 LAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDK 276
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 70-289 2.42e-63

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 201.29  E-value: 2.42e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   70 VSLTRKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWL 149
Cdd:PLN00182  39 VCLTQKLIAEMIGTYFIIFSGCGVVVVNVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  150 QVPAYVAVQALASVCAAFALKGVFH--PFLSGGVTVPDatvSTAQAFFTEFIISFNLLFVVTAVATDTRAVGELAGIAVG 227
Cdd:PLN00182 119 QVPLYIGAQLTGSLLASLTLRLMFNvtPEAFFGTTPTD---SSGQALVAEIIISFLLMFVISGVATDSRAVGELAGIAVG 195

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13447791  228 AAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVYKAVKLRDE 289
Cdd:PLN00182 196 MTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLIRFTDK 257
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 71-284 8.15e-59

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 188.03  E-value: 8.15e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  71 SLTRKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQ 150
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791 151 VPAYVAVQALASVCAAFALKGVFHP--------FLSGGV--TVPDATVSTAQAFFTEFIISFNLLFVVTAVATDTRAVGE 220
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGhfdatedgGAKLGVfaTSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791 221 LAGIAVGAAVTLNILVAGPTTGGSMNPVRTLGPAVAA------GNYRQLWIYLLAPTLGALAGASVYKAV 284
Cdd:COG0580 161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRAL 230
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 69-287 1.89e-55

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 180.82  E-value: 1.89e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   69 DVSLTRKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPW 148
Cdd:PLN00183  41 DLNPARMVLAEMVGTFILMFCVCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPW 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  149 LQVPAYVAVQALASVCAAFALKGVFHPFLSGGVTVPdaTVSTAQAFFTEFIISFNLLFVVTAVATDTRAVGELAGIAVGA 228
Cdd:PLN00183 121 SKVPLYITAQTVGSVLATYVGVSVYGVKADLMTTKP--AQGCSSAFWVEFIATFIVMFLAASLTSQPQSLGHLSGFVIGI 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 13447791  229 AVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVYKAVKLR 287
Cdd:PLN00183 199 AIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLLRLR 257
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 74-282 4.57e-53

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 173.21  E-value: 4.57e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  74 RKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACA-GLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVP 152
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAwGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791 153 AYVAVQALASVCAAFALKGVF-----------HPFLSGGVTVPDATVSTAQAFFTEFIISFNLLFVVTAVATDTR--AVG 219
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYyglyleflganNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNgpPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13447791 220 ELAGIAVGAAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYR---QLWIYLLAPTLGALAGASVYK 282
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYD 226
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 70-281 2.22e-50

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 165.95  E-value: 2.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791    70 VSLTRKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACA---GLAVATVILSTGHISGAHLNPSLTIAFAALRHF 146
Cdd:pfam00230   5 VSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVAlafGLALATLVYCAGHISGAHLNPAVTLALLVGRRF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   147 PWLQVPAYVAVQALASVCAAFALKGVFHPFL--SGGVTVPDATVSTAQAFFTEFIISFNLLFVVTAVATDTRAV--GELA 222
Cdd:pfam00230  85 SLLRAIFYIVAQLLGAIAGAALLYGVTVGLQraGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGslGTVA 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13447791   223 GIAVGAAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVY 281
Cdd:pfam00230 165 PLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 78-281 3.97e-47

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 157.46  E-value: 3.97e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791    78 AEFVGTFILIFFA--TAAPIVNQKYGGAISPFGNAACA---GLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVP 152
Cdd:TIGR00861   1 AEFLGTFLLVFFGvgSALGVNVAGAYGAVGGGQFLGVAlafGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   153 AYVAVQALASVCAAFALKGVFHPFLSGG---VTVPDATVSTAQAFFTEFIISFNLLFVVTAVATDTRAV--GELAGIAVG 227
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNlavNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVprGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 13447791   228 AAVTLNILVAGPTTGGSMNPVRTLGPAVAAG--NYRQLWIYLLAPTLGALAGASVY 281
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
PRK05420 PRK05420
aquaporin Z; Provisional
 72-284 2.35e-30

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 114.29  E-value: 2.35e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   72 LTRKLGAEFVGTFILIF-------FATAAPIVnqkyggAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALR 144
Cdd:PRK05420   1 MFKKLAAEFFGTFWLVFggcgsavLAAAFPEL------GIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  145 HFPWLQVPAYVAVQALASVCAAFAL------KGVFHPFLSG------GVTVPDAtVSTAQAFFTEFIISFNLLFVVTAvA 212
Cdd:PRK05420  75 RFPAKELVPYIIAQVVGGIAAAAVLyliasgKAGFDLAGSGfasngyGEHSPGG-YSLLAALVCEVVLTAFFLLVILG-A 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13447791  213 TDTRAVGELAGIAVGAAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNY--RQLWIYLLAPTLGALAGASVYKAV 284
Cdd:PRK05420 153 TDKRAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLL 226
PLN00166 PLN00166
aquaporin TIP2; Provisional
 78-277 1.96e-26

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 104.25  E-value: 1.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   78 AEFVGTFILIFFATAAPIVNQKY--GGAISPFGNAACA---GLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVP 152
Cdd:PLN00166  23 SEFIATLLFVFAGVGSAIAFAKLtsDAALDPAGLVAVAvahAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITIITGF 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  153 AYVAVQALASVCAAFALKgvfhpFLSGGVTVPD----ATVSTAQAFFTEFIISFNLLFVVTAVATDTR--AVGELAGIAV 226
Cdd:PLN00166 103 FYWIAQCLGSIVACLLLV-----FVTNGESVPThgvaAGLGAIEGVVMEIVVTFALVYTVYATAADPKkgSLGTIAPIAI 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 13447791  227 GAAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTL-GALAG 277
Cdd:PLN00166 178 GFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVgGALAG 229
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 74-282 3.19e-25

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 102.13  E-value: 3.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   74 RKLGAEFVGTFILIFFATAAPIVNQKYGGAISPFGNAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVPA 153
Cdd:PTZ00016  51 REYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPG 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  154 YVAVQALASVCAAFALKGVFHPFLS----------------GGVTVPDATVSTAQAFFTEFIISFNLLFVVTAV--ATDT 215
Cdd:PTZ00016 131 YFVAQLLGAFVGAACVYGLYYGFFKdhgipelpwetmangfAGVFATYPREGNFYAIFSELILTAILLLVILAItdPNNC 210

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13447791  216 RAVGELAgIAVGAAVTLNILVAGPTTGGSMNPVRTLGPAV-----------AAGNYrQLWIYLLAPTLGALAGASVYK 282
Cdd:PTZ00016 211 PAFNYLP-VAVGLLVFVIGISFGGNTGYALNPARDLGPRLfsailwgsevfTKDNY-YFWVPLVAPFVGAVLGMFLYD 286
PLN00027 PLN00027
aquaporin TIP; Provisional
 78-281 3.26e-20

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 87.53  E-value: 3.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   78 AEFVGTFILIFFATAAPIVNQKY--GGAISPFGNAACA---GLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVP 152
Cdd:PLN00027  25 AEFISTLIFVFAGEGSGMAFNKLtdNGSTTPAGLVAAAlahAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITLLRGI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  153 AYVAVQALASVCAAFALKgvfhpFLSGGVTVP----DATVSTAQAFFTEFIISFNLLFVVTAVATDTR--AVGELAGIAV 226
Cdd:PLN00027 105 LYWIAQLLGSVVACLLLK-----FSTGGLETSafslSSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKkgDLGIIAPIAI 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 13447791  227 GAAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVY 281
Cdd:PLN00027 180 GFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVY 234
PLN00167 PLN00167
aquaporin TIP5; Provisional
 78-284 7.83e-16

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 75.71  E-value: 7.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791   78 AEFVGTFILIFFATAAPIVNQKY--GGAISPFG---NAACAGLAVATVILSTGHISGAHLNPSLTIAFAALRHFPWLQVP 152
Cdd:PLN00167  27 AEFISTFFFVFAAVGSAMSSRKLmpDAASDPSSlliVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTAM 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  153 AYVAVQALASVCAAFALKgvfhpFLSGGVTVPDATVSTAQAFF----TEFIISFNLLFVVTAVATDTRA-VGELAGIAVG 227
Cdd:PLN00167 107 FYWISQMLASVMACLFLK-----VTTVGQHVPTYKIAEEMTGFgasvLEGVLTFGLVYTVYAAGDPRRGlLGAIGPLAIG 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 13447791  228 AAVTLNILVAGPTTGGSMNPVRTLGPAVAAGNYRQLWIYLLAPTLGALAGASVYKAV 284
Cdd:PLN00167 182 LVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNV 238
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 60-167 3.21e-05

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 44.17  E-value: 3.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13447791  60 TCVVEIPAPDVSLTRKLGAEFVGTFILIF--FATAAPiVNQKYGGAISPFgnaaCAGLAVATVILSTGHISGAHLNP--S 135
Cdd:cd00333 117 GIFGTYPSPGVSNGNAFFVEFIGTFILVLvvFATTDD-PNGPPPGGLAPL----AIGLLVAAIGLAGGPITGASMNParS 191

                        90       100       110
                ....*....|....*....|....*....|..
gi 13447791 136 LTIAFAALRHFPWLQVPAYVAVQALASVCAAF 167
Cdd:cd00333 192 LGPALFTGLARHWHYFWVYWVGPLIGAIAGAL 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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