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Conserved domains on  [gi|124376898|gb|AAI32813|]
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FNDC3A protein [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
466-855 4.31e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 4.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  466 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 540
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  541 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 620
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  621 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 698
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  699 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 776
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  777 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 855
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
811-1070 3.03e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.35  E-value: 3.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  811 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 887
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  888 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 960
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  961 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 1037
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 124376898 1038 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 371-462 2.20e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  371 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 124376898  450 GTSGFSEEVLYYT 462
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 267-366 2.29e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  267 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 345
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 124376898  346 KVQAEYNSIKGTPSEAEIFTT 366
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
466-855 4.31e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 4.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  466 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 540
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  541 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 620
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  621 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 698
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  699 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 776
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  777 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 855
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
811-1070 3.03e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.35  E-value: 3.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  811 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 887
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  888 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 960
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  961 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 1037
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 124376898 1038 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 371-462 2.20e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  371 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 124376898  450 GTSGFSEEVLYYT 462
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 467-559 2.43e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  467 PSMPASPVLTKAGITWLSLQWSKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 545
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 124376898  546 EGKSNPSEVVEFTT 559
Cdd:cd00063    80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
865-940 2.18e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 2.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   865 DEIENPHYSP--STCLAISWEKPCDHGSEILAYSIDF------GDKQSLTVGKVT-SYIINNLQPDTTYRIRIQALNSLG 935
Cdd:pfam00041    1 SAPSNLTVTDvtSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 124376898   936 AGPFS 940
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 875-947 8.92e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.43  E-value: 8.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  875 STCLAISWEKPCDHGSEILAYSIDFGDKQS-------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 947
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 756-838 9.72e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 9.72e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    756 PGPPdqcKPPQVTCRSATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQAL 832
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 124376898    833 SVVGAG 838
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 267-366 2.29e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  267 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 345
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 124376898  346 KVQAEYNSIKGTPSEAEIFTT 366
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
765-841 2.68e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   765 PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 371-452 8.02e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 8.02e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    371 PDIPNPPRIANRTKNSLTLQWKAPSDNG--SKIQNFVLEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSARND 448
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 124376898    449 YGTS 452
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
374-455 1.33e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   374 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSARNDYGT 451
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 124376898   452 SGFS 455
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 875-937 3.15e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.15e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    875 STCLAISWEKPCDHG--SEILAYSIDFGDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
272-359 4.30e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 4.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   272 PVASDIQARTVVLTWSPPSSLiNGEtdessvpeLYGYEVLISSTGKDGKYKSVYV-GEETNITLNDLKPAMDYHAKVQAE 350
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDG-NGP--------ITGYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 124376898   351 YNSIKGTPS 359
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 267-352 1.05e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.83  E-value: 1.05e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    267 SNIVKPVASDIQARTVVLTWSPPSslingetDESSVPELYGYEVLISSTGKDGKYKSVyVGEETNITLNDLKPAMDYHAK 346
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-------DDGITGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 124376898    347 VQAEYN 352
Cdd:smart00060   74 VRAVNG 79
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
466-855 4.31e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 4.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  466 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 540
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  541 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 620
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  621 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 698
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  699 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 776
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  777 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 855
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
441-667 1.56e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.12  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  441 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDegiSYILEMEEETSGyGFKPKYDG 520
Cdd:COG3401   207 YRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESDAT---GYRVYRSNSGDG-PFTKVATV 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  521 EDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEFTTCPDKPGIPVkpSVKGKIHSHSF-KITWDPPKDNGgatINK 598
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSiTLSWTASSDAD---VTG 357

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124376898  599 YVVEMAEGSNGNkWEMIYSGATREHLCDR-LNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPCLP 667
Cdd:COG3401   358 YNVYRSTSGGGT-YTKIAETVTTTSYTDTgLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGESLT 427
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
811-1070 3.03e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.35  E-value: 3.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  811 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 887
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  888 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 960
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  961 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 1037
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 124376898 1038 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 371-462 2.20e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  371 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 124376898  450 GTSGFSEEVLYYT 462
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 467-559 2.43e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  467 PSMPASPVLTKAGITWLSLQWSKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 545
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 124376898  546 EGKSNPSEVVEFTT 559
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 678-754 4.95e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 4.95e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124376898  678 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT 754
Cdd:cd00063    16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
273-612 7.27e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.73  E-value: 7.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  273 VASDIQARTVVLTWSPpssliNGETDESsvpelyGYEVLISSTGkDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAE-Y 351
Cdd:COG3401   240 TATADTPGSVTLSWDP-----VTESDAT------GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdA 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  352 NSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGskIQNFVLEWDEGKGnGEFCQ-CYMGSQKQFKI 430
Cdd:COG3401   308 AGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSGG-GTYTKiAETVTTTSYTD 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  431 TKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 510
Cdd:COG3401   385 TGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDT 464

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  511 GYGFKPKYDGEDLAYTVKNLRRSTKYkfKVIAYNSEGKSNPSEVVEFTTcPDKPGIPVKPSVKGKIHShsfKITWDPPKD 590
Cdd:COG3401   465 GNAVPFTTTSSTVTATTTDTTTANLS--VTTGSLVGGSGASSVTNSVSV-IGASAAAAVGGAPDGTPN---VTGASPVTV 538

                         330       340
                  ....*....|....*....|..
gi 124376898  591 NGGATINKYVVEMAEGSNGNKW 612
Cdd:COG3401   539 GASTGDVLITDLVSLTTSASSS 560
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 756-848 1.50e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  756 PGPPDQckpPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV-EGSMQIC--YCGPGLSYEIKGLSPATTYYCRVQAL 832
Cdd:cd00063     1 PSPPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 124376898  833 SVVGAGPFSEVVACVT 848
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
865-940 2.18e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 2.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   865 DEIENPHYSP--STCLAISWEKPCDHGSEILAYSIDF------GDKQSLTVGKVT-SYIINNLQPDTTYRIRIQALNSLG 935
Cdd:pfam00041    1 SAPSNLTVTDvtSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 124376898   936 AGPFS 940
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 564-657 4.69e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 4.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  564 PGIPVKPSVKGkIHSHSFKITWDPPKDNGGAtINKYVVEMAEgSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCI 641
Cdd:cd00063     1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGGP-ITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 124376898  642 SDGGQSAVSESLLVQT 657
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 875-947 8.92e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.43  E-value: 8.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  875 STCLAISWEKPCDHGSEILAYSIDFGDKQS-------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 947
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
872-1165 3.47e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.25  E-value: 3.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  872 YSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 951
Cdd:COG3401   153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  952 PDPP-RLECVAFSHQNLKLKWGEGTpktlSTDSIQYHL-QMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEA 1029
Cdd:COG3401   233 PSAPtGLTATADTPGSVTLSWDPVT----ESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898 1030 G-EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWeclQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS-SFRYS 1106
Cdd:COG3401   309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTTtSYTDT 385

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 124376898 1107 SLQLNCEYRFRVCAIrqcqDSLGhqdLVGPYSTTVLFISQRTEPPASTNRDTVESTRTR 1165
Cdd:COG3401   386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESLTASVDAVPLTD 437
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 756-838 9.72e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 9.72e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    756 PGPPdqcKPPQVTCRSATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQAL 832
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 124376898    833 SVVGAG 838
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 267-366 2.29e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  267 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 345
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 124376898  346 KVQAEYNSIKGTPSEAEIFTT 366
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
765-841 2.68e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   765 PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 662-744 3.82e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.82e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    662 PGPclPPRLQGRPKAKE-IQLRWGPPLVDGG-SPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAAN 739
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 124376898    740 KMGFG 744
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 371-452 8.02e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 8.02e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    371 PDIPNPPRIANRTKNSLTLQWKAPSDNG--SKIQNFVLEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSARND 448
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 124376898    449 YGTS 452
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
374-455 1.33e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   374 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSARNDYGT 451
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 124376898   452 SGFS 455
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 467-549 1.84e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.84e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    467 PSMPASPVLTKAGITWLSLQWSKPsgtPSDEGISYILEMEEETSGYGFKPK---YDGEDLAYTVKNLRRSTKYKFKVIAY 543
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPP---PDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 124376898    544 NSEGKS 549
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
678-747 2.32e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 2.32e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124376898   678 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREVYQ--GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 875-937 3.15e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.15e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    875 STCLAISWEKPCDHG--SEILAYSIDFGDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 952-1042 9.51e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 9.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  952 PDPPR-LECVAFSHQNLKLKWGEgtPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC---HTYKVQRLNESTSYKFCIQACN 1027
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 124376898 1028 EAGEGPLSQEYIFTT 1042
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 564-647 3.29e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.29e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    564 PGIPVKPSVKGkIHSHSFKITWDPPKDNGGatiNKYVVE--MAEGSNGNKWEMIY-SGATREHLCDRLNPGCFYRLRVYC 640
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPPDDGI---TGYIVGyrVEYREEGSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                    ....*..
gi 124376898    641 ISDGGQS 647
Cdd:smart00060   77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
272-359 4.30e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 4.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   272 PVASDIQARTVVLTWSPPSSLiNGEtdessvpeLYGYEVLISSTGKDGKYKSVYV-GEETNITLNDLKPAMDYHAKVQAE 350
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDG-NGP--------ITGYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 124376898   351 YNSIKGTPS 359
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 951-1032 6.58e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 6.58e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    951 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-YKVQRLNESTSYKFCIQACNEA 1029
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 124376898   1030 GEG 1032
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
578-650 1.47e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.47e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124376898   578 SHSFKITWDPPKDNGGaTINKYVVEMAEGSNGNKW-EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 650
Cdd:pfam00041   13 STSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
470-552 1.63e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   470 PASPVLTKAGITWLSLQWSKPSgTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSEGK 548
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 124376898   549 SNPS 552
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 267-352 1.05e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.83  E-value: 1.05e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898    267 SNIVKPVASDIQARTVVLTWSPPSslingetDESSVPELYGYEVLISSTGKDGKYKSVyVGEETNITLNDLKPAMDYHAK 346
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-------DDGITGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 124376898    347 VQAEYN 352
Cdd:smart00060   74 VRAVNG 79
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
710-836 7.20e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.78  E-value: 7.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  710 REVYQGSEVECTVSSLLPGkTYSFRLRAANKMG---FGPFSEKCDITTAPGPPdqckpPQVTCRSATC----AQVNWEVP 782
Cdd:COG4733   579 VSVPRTSGTSFEVPGIYAG-DYEVRVRAINALGvssAWAASSETTVTGKTAPP-----PAPTGLTATGglggITLSWSFP 652

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124376898  783 lsNGTDVTEYRLEWGGV---EGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 836
Cdd:COG4733   653 --VDADTLRTEIRYSTTgdwASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
775-935 1.36e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  775 AQVNWEVPlsngTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLsPATTYYCRVQALSVVG------AGPFSEVVACVT 848
Cdd:COG4733   554 LTVSWDAP----AGAVAYEVEWRRDDGNWVSVPRTSGTSFEVPGI-YAGDYEVRVRAINALGvssawaASSETTVTGKTA 628

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898  849 PPSVP-GIVTclqEISDDEIEnphyspstclaISWEKPCDhgSEILAYSI---DFGDKQSLTV----GKVTSYIINNLQP 920
Cdd:COG4733   629 PPPAPtGLTA---TGGLGGIT-----------LSWSFPVD--ADTLRTEIrysTTGDWASATVaqalYPGNTYTLAGLKA 692

                         170
                  ....*....|....*
gi 124376898  921 DTTYRIRIQALNSLG 935
Cdd:COG4733   693 GQTYYYRARAVDRSG 707
fn3 pfam00041
Fibronectin type III domain;
952-1035 6.52e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.01  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124376898   952 PDPPRLECVAFSHQNLKLKWGEgtPKTLSTDSIQYHLQMEDKNG------RFVSlyrGPCHTYKVQRLNESTSYKFCIQA 1025
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTP--PPDGNGPITGYEVEYRPKNSgepwneITVP---GTTTSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 124376898  1026 CNEAGEGPLS 1035
Cdd:pfam00041   76 VNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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