NCBI Conserved Domain Search

Ankyrin repeat [Signal transduction mechanisms];

23-283

6.92e-36

Ankyrin repeat [Signal transduction mechanisms];

Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 132.39 E-value: 6.92e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  23 KQHLNELADNKQTVIYTHFGKSGDTVLHYAARHGHVDILRYLVEELNMDIEVYNSDYKRALHEASSMGHYECVRFLICRG 102
Cdd:COG0666  31 LLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 103 AKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLLLAKPDIwKTKSKTGRTP 182
Cdd:COG0666 111 ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV-NARDNDGETP 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 183 LHTAAMHGCEDAVKILLQSCCyEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQASVTAQEEA 262
Cdd:COG0666 190 LHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAALI 267

                       250       260
                ....*....|....*....|.
gi 62202327 263 LSFLVHHLGMDINSRATKLEL 283
Cdd:COG0666 268 VKLLLLALLLLAAALLDLLTL 288

Ank_2

Ankyrin repeats (3 copies);

286-366

4.57e-13

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 4.57e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   286 LHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQMGLTDTEDNtGNTARQYAIKPHIKDVFEN 365
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN-GRTALHYAARSGHLEIVKL 79


                  .
gi 62202327   366 L 366
Cdd:pfam12796  80 L 80

Name

Accession

Description

Interval

E-value

ANKYR

Ankyrin repeat [Signal transduction mechanisms];

23-283

6.92e-36

Ankyrin repeat [Signal transduction mechanisms];

Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 132.39 E-value: 6.92e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  23 KQHLNELADNKQTVIYTHFGKSGDTVLHYAARHGHVDILRYLVEELNMDIEVYNSDYKRALHEASSMGHYECVRFLICRG 102
Cdd:COG0666  31 LLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 103 AKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLLLAKPDIwKTKSKTGRTP 182
Cdd:COG0666 111 ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV-NARDNDGETP 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 183 LHTAAMHGCEDAVKILLQSCCyEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQASVTAQEEA 262
Cdd:COG0666 190 LHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAALI 267

                       250       260
                ....*....|....*....|.
gi 62202327 263 LSFLVHHLGMDINSRATKLEL 283
Cdd:COG0666 268 VKLLLLALLLLAAALLDLLTL 288

Ank_2

Ankyrin repeats (3 copies);

49-142

5.81e-18

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 77.85 E-value: 5.81e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327    49 LHYAARHGHVDILRYLVEElNMDIEVYNSDYKRALHEASSMGHYECVRFLIcRGAKVDsLKKADWTPLMMACTRRNLEVI 128
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVN-LKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 62202327   129 QELLDYGADPTLQN 142
Cdd:pfam12796  78 KLLLEKGADINVKD 91

PHA03100

ankyrin repeat protein; Provisional

160-366

6.65e-15

ankyrin repeat protein; Provisional

Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 75.47 E-value: 6.65e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  160 IINHLLLAKPDIWKTKSKTGRTPLHTAAMHGCEDAVKILLQSCCYePDEKDSCGVTPFMDAIRNGHIA-----VAKLLLE 234
Cdd:PHA03100  16 KNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGAD-INSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  235 dHQASPSAVDILGAQPLHQASVT--AQEEALSFLVHHlGMDINSRaTKLELTALHYAAKDGHTST--------------- 297
Cdd:PHA03100  95 -YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDN-GANVNIK-NSDGENLLHLYLESNKIDLkilkllidkgvdina 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62202327  298 ---IKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQMGL-TDTEDNTGNTARQYAIKPHIKDVFENL 366
Cdd:PHA03100 172 knrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGAnPNLVNKYGDTPLHIAILNNNKEIFKLL 244

Ank_2

Ankyrin repeats (3 copies);

286-366

4.57e-13

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 4.57e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   286 LHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQMGLTDTEDNtGNTARQYAIKPHIKDVFEN 365
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN-GRTALHYAARSGHLEIVKL 79


                  .
gi 62202327   366 L 366
Cdd:pfam12796  80 L 80

PTZ00322

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

233-346

7.83e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.13 E-value: 7.83e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  233 LEDHQASPSAVDILGAQPLHQAsvtAQEEALSFLVHHLgmdinsraTKLELTALhyaAKDGHTSTIKTLLALGADLHARD 312
Cdd:PTZ00322  47 IDTHLEALEATENKDATPDHNL---TTEEVIDPVVAHM--------LTVELCQL---AASGDAVGARILLTGGADPNCRD 112

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 62202327  313 AKGRSALHMACIGQHVDTVRMLLQMG----LTDTEDNT 346
Cdd:PTZ00322 113 YDGRTPLHIACANGHVQVVRVLLEFGadptLLDKDGKT 150

TRPV5-6

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...

181-321

1.52e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.

Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 53.09 E-value: 1.52e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 181 TPLHTAAMHGCEDAVKILLQSCCYEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdhqASPSAVDI-------LGAQPLHQ 253
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLME---AAPELVNEpmtsdlyQGETALHI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 254 ASVTAQEEalsfLVHHL---GMDINS-RATKLELT------------ALHYAAKDGHTSTIKTLLALGADLHARDAKGRS 317
Cdd:cd22192  96 AVVNQNLN----LVRELiarGADVVSpRATGTFFRpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNT 171


                ....
gi 62202327 318 ALHM 321
Cdd:cd22192 172 VLHI 175

ANK

smart00248

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...

112-140

8.06e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.

Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 8.06e-04

                           10        20
                   ....*....|....*....|....*....
gi 62202327    112 DWTPLMMACTRRNLEVIQELLDYGADPTL 140
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30

trp

TIGR00870

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...

217-332

6.03e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 38.52 E-value: 6.03e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   217 FMDAIRNGHIAVAKLLLEdHQASPSAVDILgaqpLHQAS---VTAQEEALSFLVHH--------LGMDINSRATKLELTA 285
Cdd:TIGR00870  57 FVAAIENENLELTELLLN-LSCRGAVGDTL----LHAISleyVDAVEAILLHLLAAfrksgpleLANDQYTSEFTPGITA 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 62202327   286 LHYAAKDGHTSTIKTLLALGADLHARdAKGRSALhmacIGQHVDTVR 332
Cdd:TIGR00870 132 LHLAAHRQNYEIVKLLLERGASVPAR-ACGDFFV----KSQGVDSFY 173

Name

Accession

Description

Interval

E-value

ANKYR

Ankyrin repeat [Signal transduction mechanisms];

23-283

6.92e-36

Ankyrin repeat [Signal transduction mechanisms];

Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 132.39 E-value: 6.92e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  23 KQHLNELADNKQTVIYTHFGKSGDTVLHYAARHGHVDILRYLVEELNMDIEVYNSDYKRALHEASSMGHYECVRFLICRG 102
Cdd:COG0666  31 LLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 103 AKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLLLAKPDIwKTKSKTGRTP 182
Cdd:COG0666 111 ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV-NARDNDGETP 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 183 LHTAAMHGCEDAVKILLQSCCyEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQASVTAQEEA 262
Cdd:COG0666 190 LHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAALI 267

                       250       260
                ....*....|....*....|.
gi 62202327 263 LSFLVHHLGMDINSRATKLEL 283
Cdd:COG0666 268 VKLLLLALLLLAAALLDLLTL 288

ANKYR

Ankyrin repeat [Signal transduction mechanisms];

26-319

8.26e-36

Ankyrin repeat [Signal transduction mechanisms];

Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 132.00 E-value: 8.26e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  26 LNELADNKQTVIYTHFGKSGDTVLHYAARHGHVDILRYLVEELNMDIEVYNSDYKRALHEASSMGHYECVRFLICRGAKV 105
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 106 DSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLLLAKPDIwKTKSKTGRTPLHT 185
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADV-NAQDNDGNTPLHL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 186 AAMHGCEDAVKILLQSCCyEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQASVTAQEEALSF 265
Cdd:COG0666 160 AAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDNDGKTALDLAAENGNLEIVKL 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 62202327 266 LVHHLGmdINSRATKLELTALHYAAKDGHTSTIKTLLALGADLHARDAKGRSAL 319
Cdd:COG0666 238 LLEAGA--DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289

ANKYR

Ankyrin repeat [Signal transduction mechanisms];

9-246

2.57e-35

Ankyrin repeat [Signal transduction mechanisms];

Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 130.84 E-value: 2.57e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   9 LLIKAVQHGELCTVKQHLNELADNKQTviythfGKSGDTVLHYAARHGHVDILRYLVEeLNMDIEVYNSDYKRALHEASS 88
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAK------DDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAY 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  89 MGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLLLAK 168
Cdd:COG0666 130 NGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG 209

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62202327 169 PDIwKTKSKTGRTPLHTAAMHGCEDAVKILLQScCYEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEDHQASPSAVDIL 246
Cdd:COG0666 210 ADV-NAKDNDGKTALDLAAENGNLEIVKLLLEA-GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285

ANKYR

Ankyrin repeat [Signal transduction mechanisms];

59-367

1.85e-34

Ankyrin repeat [Signal transduction mechanisms];

Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 128.53 E-value: 1.85e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  59 DILRYLVEELNMDIEVYNSDYKRALHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADP 138
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 139 TLQNKDGWSSFHIACREGDPAIINHLLLAKPDIwKTKSKTGRTPLHTAAMHGCEDAVKILLQSCCyEPDEKDSCGVTPFM 218
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADV-NARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLH 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 219 DAIRNGHIAVAKLLLEdHQASPSAVDILGAqplhqasvtaqeealsflvhhlgmdinsratklelTALHYAAKDGHTSTI 298
Cdd:COG0666 159 LAAANGNLEIVKLLLE-AGADVNARDNDGE-----------------------------------TPLHLAAENGHLEIV 202

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 299 KTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQMGLTDT-EDNTGNTARQYAIKPHIKDVFENLA 367
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNaKDKDGLTALLLAAAAGAALIVKLLL 272

Ank_2

Ankyrin repeats (3 copies);

49-142

5.81e-18

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 77.85 E-value: 5.81e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327    49 LHYAARHGHVDILRYLVEElNMDIEVYNSDYKRALHEASSMGHYECVRFLIcRGAKVDsLKKADWTPLMMACTRRNLEVI 128
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVN-LKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 62202327   129 QELLDYGADPTLQN 142
Cdd:pfam12796  78 KLLLEKGADINVKD 91

Ank_2

Ankyrin repeats (3 copies);

10-107

8.06e-17

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 74.77 E-value: 8.06e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327    10 LIKAVQHGELCTVKQHLNELADNKQTviythfGKSGDTVLHYAARHGHVDILRYLVEELNMDIEVYNsdyKRALHEASSM 89
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ------DKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG---RTALHYAARS 71

                          90
                  ....*....|....*...
gi 62202327    90 GHYECVRFLICRGAKVDS 107
Cdd:pfam12796  72 GHLEIVKLLLEKGADINV 89

Ank_2

Ankyrin repeats (3 copies);

149-234

8.68e-16

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.07 E-value: 8.68e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   149 FHIACREGDPAIINHLLLAKPDIwKTKSKTGRTPLHTAAMHGCEDAVKILLQSCCYEPDEKdscGVTPFMDAIRNGHIAV 228
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GRTALHYAARSGHLEI 76


                  ....*.
gi 62202327   229 AKLLLE 234
Cdd:pfam12796  77 VKLLLE 82

PHA03100

ankyrin repeat protein; Provisional

160-366

6.65e-15

ankyrin repeat protein; Provisional

Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 75.47 E-value: 6.65e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  160 IINHLLLAKPDIWKTKSKTGRTPLHTAAMHGCEDAVKILLQSCCYePDEKDSCGVTPFMDAIRNGHIA-----VAKLLLE 234
Cdd:PHA03100  16 KNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGAD-INSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  235 dHQASPSAVDILGAQPLHQASVT--AQEEALSFLVHHlGMDINSRaTKLELTALHYAAKDGHTST--------------- 297
Cdd:PHA03100  95 -YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDN-GANVNIK-NSDGENLLHLYLESNKIDLkilkllidkgvdina 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62202327  298 ---IKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQMGL-TDTEDNTGNTARQYAIKPHIKDVFENL 366
Cdd:PHA03100 172 knrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGAnPNLVNKYGDTPLHIAILNNNKEIFKLL 244

PHA03100

ankyrin repeat protein; Provisional

49-275

1.81e-14

ankyrin repeat protein; Provisional

Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 74.32 E-value: 1.81e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   49 LHYAARHGHVDILRYLVEElNMDIEVYNSDYKRALHEASSMGHY-----ECVRFLICRGAKVDSLKKADWTPLMMACTRR 123
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDN-GADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKK 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  124 --NLEVIQELLDYGADPTLQNKDGWSSFHIA--CREGDPAIINHLLLAKPDIWKtksktgrtplhtaamhgcEDAVKILL 199
Cdd:PHA03100 118 snSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVDINA------------------KNRVNYLL 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62202327  200 qSCCYEPDEKDSCGVTPFMDAIRNGHIAVAKLLLeDHQASPSAVDILGAQPLHQASVTAQEEALSFLVHHlGMDIN 275
Cdd:PHA03100 180 -SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLL-DLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN-GPSIK 252

PHA03100

ankyrin repeat protein; Provisional

43-171

2.49e-14

ankyrin repeat protein; Provisional

Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 73.55 E-value: 2.49e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   43 KSGDTVLHYAA--RHGHVDILRYLvEELNMDIEVYNSDYKRALHEASSMGHY--ECVRFLICRGAKVDSLKKADW----- 113
Cdd:PHA03100 104 NNGITPLLYAIskKSNSYSIVEYL-LDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNRVNYllsyg 182

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62202327  114 -----------TPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLLLAKPDI 171
Cdd:PHA03100 183 vpinikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251

PHA03095

ankyrin-like protein; Provisional

93-335

2.55e-14

ankyrin-like protein; Provisional

Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 73.91 E-value: 2.55e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   93 ECVRFLICRGAKVDSLKKADWTPLMM-ACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACR--EGDPAIINHLLLAKP 169
Cdd:PHA03095  64 DIVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGA 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  170 DIWKTKsKTGRTPLHtAAM--HGCEDA-VKILLQSCCYePDEKDSCGVTP---FMDAIRNGHIAVAKLLleDHQASPSAV 243
Cdd:PHA03095 144 DVNALD-LYGMTPLA-VLLksRNANVElLRLLIDAGAD-VYAVDDRFRSLlhhHLQSFKPRARIVRELI--RAGCDPAAT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  244 DILGAQPLHQASVTAQEEA--LSFLVHHlGMDINSRaTKLELTALHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHM 321
Cdd:PHA03095 219 DMLGNTPLHSMATGSSCKRslVLPLLIA-GISINAR-NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSL 296

                        250
                 ....*....|....
gi 62202327  322 ACIGQHVDTVRMLL 335
Cdd:PHA03095 297 MVRNNNGRAVRAAL 310

Ank_2

Ankyrin repeats (3 copies);

83-174

5.91e-14

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 66.68 E-value: 5.91e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327    83 LHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYgADPTLQNkDGWSSFHIACREGDPAIIN 162
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 62202327   163 HLLLAKPDIWKT 174
Cdd:pfam12796  79 LLLEKGADINVK 90

PHA02875

ankyrin repeat protein; Provisional

113-307

2.61e-13

ankyrin repeat protein; Provisional

Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 70.41 E-value: 2.61e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  113 WTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLLLAKPDIWKTKSKTGRTPLHTAAMHGCE 192
Cdd:PHA02875  36 ISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  193 DAVKILLQSCCyEPDEKDSCGVTPFMDAIRNGHIAVAKLLLeDHQASPSAVDILGAQPLHQASVTAQEEALSFLVHHlGM 272
Cdd:PHA02875 116 DIMKLLIARGA-DPDIPNTDKFSPLHLAVMMGDIKGIELLI-DHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS-GA 192

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 62202327  273 DINSRATKLELTALHYAAKDGHTSTIKTLLALGAD 307
Cdd:PHA02875 193 NIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGAD 227

Ank_2

Ankyrin repeats (3 copies);

286-366

4.57e-13

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 4.57e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   286 LHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQMGLTDTEDNtGNTARQYAIKPHIKDVFEN 365
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN-GRTALHYAARSGHLEIVKL 79


                  .
gi 62202327   366 L 366
Cdd:pfam12796  80 L 80

Ank_2

Ankyrin repeats (3 copies);

183-312

5.41e-13

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.98 E-value: 5.41e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   183 LHTAAMHGCEDAVKILLQsCCYEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEDhqaspsavdilgaqplhqasvtaqeea 262
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 62202327   263 lsflvhhlgmdINSRATKLELTALHYAAKDGHTSTIKTLLALGADLHARD 312
Cdd:pfam12796  53 -----------ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91

PHA02878

ankyrin repeat protein; Provisional

126-322

7.83e-13

ankyrin repeat protein; Provisional

Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.52 E-value: 7.83e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  126 EVIQELLDYGADPTLQNKD-GWSSFHIACREGDPAIINHLLL--AKPDIwktKSKTGRTPLHTAAMHGCEDAVKILLQSC 202
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSygANVNI---PDKTNNSPLHHAVKHYNKPIVHILLENG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  203 CYEpDEKDSCGVTPFmdairngHIAVAKLLledhqaspsavdilgaqplhqasvtaQEEALSFLVHHlGMDINSRATKLE 282
Cdd:PHA02878 225 AST-DARDKCGNTPL-------HISVGYCK--------------------------DYDILKLLLEH-GVDVNAKSYILG 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 62202327  283 LTALHYAAKDghTSTIKTLLALGADLHARDAKGRSALHMA 322
Cdd:PHA02878 270 LTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSA 307

PHA02876

ankyrin repeat protein; Provisional

78-354

9.84e-13

ankyrin repeat protein; Provisional

Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 69.32 E-value: 9.84e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   78 DYKRALHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGD 157
Cdd:PHA02876 144 EYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  158 PAIINHLLLAKPDIWKTKsktgrtplhtaamhgcedavkillqsccyepdekdscgvTPFMDAIRNGHIAVAkLLLEDHQ 237
Cdd:PHA02876 224 IDTIKAIIDNRSNINKND---------------------------------------LSLLKAIRNEDLETS-LLLYDAG 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  238 ASPSAVDILGAQPLHQASvtaQEEALSFLVHHL---GMDINSRATKLElTALHYAAKDGH-TSTIKTLLALGADLHARDA 313
Cdd:PHA02876 264 FSVNSIDDCKNTPLHHAS---QAPSLSRLVPKLlerGADVNAKNIKGE-TPLYLMAKNGYdTENIRTLIMLGADVNAADR 339

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 62202327  314 KGRSALHMA-CIGQHVDTVRMLLQMGLT-DTEDNTGNTARQYA 354
Cdd:PHA02876 340 LYITPLHQAsTLDRNKDIVITLLELGANvNARDYCDKTPIHYA 382

PHA02874

ankyrin repeat protein; Provisional

93-303

1.64e-12

ankyrin repeat protein; Provisional

Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 68.07 E-value: 1.64e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   93 ECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINhLLLAKPDIW 172
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIK-LLLEKGAYA 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  173 KTKSKTGRTPLHTAAMHGCEDAVKILLQSCCYEPDeKDSCGVTPFMDAIRNGHIAVAKLLledHQASPSAVDILGAQPLH 252
Cdd:PHA02874 184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMN-KCKNGFTPLHNAIIHNRSAIELLI---NNASINDQDIDGSTPLH 259

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 62202327  253 QA-SVTAQEEALSFLVHHlGMDINSRATKLEL---TALHYAAKDghtSTIKTLLA 303
Cdd:PHA02874 260 HAiNPPCDIDIIDILLYH-KADISIKDNKGENpidTAFKYINKD---PVIKDIIA 310

PLN03192

Voltage-dependent potassium channel; Provisional

156-348

1.69e-12

Voltage-dependent potassium channel; Provisional

Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 68.74 E-value: 1.69e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  156 GDPAIINHLLLAK--PDIWKTKsktGRTPLHTAAMHGCEDAVKILLQSCCyEPDEKDSCGVTPFMDAIRNGHIAVAKLLL 233
Cdd:PLN03192 536 GNAALLEELLKAKldPDIGDSK---GRTPLHIAASKGYEDCVLVLLKHAC-NVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  234 edHQASPSavdilgaQPlhqasvtaqeealsflvhHLGMDInsratkleltaLHYAAKDGHTSTIKTLLALGADLHARDA 313
Cdd:PLN03192 612 --HFASIS-------DP------------------HAAGDL-----------LCTAAKRNDLTAMKELLKQGLNVDSEDH 653

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 62202327  314 KGRSALHMACIGQHVDTVRMLLQMGLTDTEDNTGN 348
Cdd:PLN03192 654 QGATALQVAMAEDHVDMVRLLIMNGADVDKANTDD 688

PHA02874

ankyrin repeat protein; Provisional

83-322

1.94e-12

ankyrin repeat protein; Provisional

Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 68.07 E-value: 1.94e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   83 LHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGAD------PTLQN-------------- 142
Cdd:PHA02874  39 LIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpiPCIEKdmiktildcgidvn 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  143 -KDGWSS--FHIACREGDPAIINHLLLAKPDIwKTKSKTGRTPLHTAAMHGCEDAVKILLQSCCYePDEKDSCGVTPFMD 219
Cdd:PHA02874 119 iKDAELKtfLHYAIKKGDLESIKMLFEYGADV-NIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHN 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  220 AIRNGHIAVAKLLLeDHQASPSAVDILGAQPLHQAsVTAQEEALSFLVHHLGM---DINSRatklelTALHYA-----AK 291
Cdd:PHA02874 197 AAEYGDYACIKLLI-DHGNHIMNKCKNGFTPLHNA-IIHNRSAIELLINNASIndqDIDGS------TPLHHAinppcDI 268

                        250       260       270
                 ....*....|....*....|....*....|.
gi 62202327  292 DghtsTIKTLLALGADLHARDAKGRSALHMA 322
Cdd:PHA02874 269 D----IIDILLYHKADISIKDNKGENPIDTA 295

PHA03100

ankyrin repeat protein; Provisional

57-338

6.31e-12

ankyrin repeat protein; Provisional

Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 66.23 E-value: 6.31e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   57 HVDILRYLVEELNM-DIEVYNSDYKRA--LHEASSMGHYECVRFLICRGAKVDSLKKADWTPLM-----MACTRRNLEVI 128
Cdd:PHA03100  10 SRIIKVKNIKYIIMeDDLNDYSYKKPVlpLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  129 QELLDYGADPTLQNKDGWSSFHIACRE--GDPAIINHLLLAKPDIwKTKSKTGRTPLHtAAMHGCEDAVKILlqsccyep 206
Cdd:PHA03100  90 KLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANV-NIKNSDGENLLH-LYLESNKIDLKIL-------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  207 dekdscgvtpfmdairnghiavaKLLLEdhqaspsavdilgaqplHQASVTAQEEALSFLVHhlGMDINSRATKLElTAL 286
Cdd:PHA03100 160 -----------------------KLLID-----------------KGVDINAKNRVNYLLSY--GVPINIKDVYGF-TPL 196

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 62202327  287 HYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQMG 338
Cdd:PHA03100 197 HYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNG 248

Ank_4

Ankyrin repeats (many copies);

282-335

7.65e-12

Ankyrin repeats (many copies);

Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 59.60 E-value: 7.65e-12

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62202327   282 ELTALHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLL 335
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54

PHA02876

ankyrin repeat protein; Provisional

83-366

1.16e-11

ankyrin repeat protein; Provisional

Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 66.24 E-value: 1.16e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   83 LHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPtlqNKDGWSSFHiACREGDpaIIN 162
Cdd:PHA02876 182 IHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI---NKNDLSLLK-AIRNED--LET 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  163 HLLLAKP-------DIWKTksktgrTPLHTAAMHGCEDAVKILLQSCCYEPDEKDSCGVTPFMDAIRNGHIAVAKLLLED 235
Cdd:PHA02876 256 SLLLYDAgfsvnsiDDCKN------TPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIM 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  236 HQASPSAVDILGAQPLHQASVTAQEEALSFLVHHLGMDINSRaTKLELTALHYAAKDGHTSTIKTLLALGADLHARDAKG 315
Cdd:PHA02876 330 LGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNAR-DYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKI 408

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 62202327  316 RSALHMACIGQH-VDTVRMLLQMGLT-DTEDNTGNTARQYAIKPHIK-DVFENL 366
Cdd:PHA02876 409 GTALHFALCGTNpYMSVKTLIDRGANvNSKNKDLSTPLHYACKKNCKlDVIEML 462

PHA02874

ankyrin repeat protein; Provisional

214-356

1.54e-11

ankyrin repeat protein; Provisional

Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 65.37 E-value: 1.54e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  214 VTPFMDAIRNGHIAVAKLLLeDHQASPSAVDILGAQPLHQASVTAQEEALSFLVHH----------------------LG 271
Cdd:PHA02874  36 TTPLIDAIRSGDAKIVELFI-KHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNgvdtsilpipciekdmiktildCG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  272 MDINSRATKLElTALHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQMG-LTDTEDNTGNTA 350
Cdd:PHA02874 115 IDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGaYANVKDNNGESP 193


                 ....*.
gi 62202327  351 RQYAIK 356
Cdd:PHA02874 194 LHNAAE 199

PHA02876

ankyrin repeat protein; Provisional

45-201

3.44e-11

ankyrin repeat protein; Provisional

Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 64.70 E-value: 3.44e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   45 GDTVLHYAARHGH-VDILRYLVEeLNMDIEVYNSDYKRALHEASSMGHY-ECVRFLICRGAKVDSLKKADWTPLMMACTR 122
Cdd:PHA02876 307 GETPLYLMAKNGYdTENIRTLIM-LGADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVR 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  123 RNLEVIQELLDYGAD-PTLQNKDGwSSFHIACREGDPAIINHLLLAKPDIWKTKSKTGRTPLHTAAMHGCE-DAVKILLQ 200
Cdd:PHA02876 386 NNVVIINTLLDYGADiEALSQKIG-TALHFALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKlDVIEMLLD 464


                 .
gi 62202327  201 S 201
Cdd:PHA02876 465 N 465

PHA02875

ankyrin repeat protein; Provisional

119-338

1.24e-10

ankyrin repeat protein; Provisional

Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 62.32 E-value: 1.24e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  119 ACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINhLLLAKPDIWKTKSKTGRTPLHTAAMHGCEDAVKIL 198
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIK-LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEEL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  199 LQSCCYEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQASVTAQEEALSFLVHHlgmdinsRA 278
Cdd:PHA02875  88 LDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIA-RGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH-------KA 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62202327  279 T-KLE----LTALHYAAKDGHTSTIKTLLALGADLHARDAKGR-SALHMACIGQHVDTVRMLLQMG 338
Cdd:PHA02875 160 ClDIEdccgCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRG 225

Ank_2

Ankyrin repeats (3 copies);

251-338

2.66e-10

Ankyrin repeats (3 copies);

Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 56.66 E-value: 2.66e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   251 LHQASVTAQEEALSFLVHHlGMDINSRaTKLELTALHYAAKDGHTSTIKTLLAlGADLHARDaKGRSALHMACIGQHVDT 330
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN-GADANLQ-DKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEI 76


                  ....*...
gi 62202327   331 VRMLLQMG 338
Cdd:pfam12796  77 VKLLLEKG 84

PHA02875

ankyrin repeat protein; Provisional

78-234

5.82e-10

ankyrin repeat protein; Provisional

Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 60.39 E-value: 5.82e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   78 DYKRALHEASSMGHYECVRFLICRGAKV-DSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREG 156
Cdd:PHA02875  67 DIESELHDAVEEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  157 DPAIINhLLLAKPDIWKTKSKTGRTPLHTAAMHGCEDAVKILLQSCCyEPD--EKDSCgVTPFMDAIRNGHIAVAKLLLE 234
Cdd:PHA02875 147 DIKGIE-LLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA-NIDyfGKNGC-VAALCYAIENNKIDIVRLFIK 223

PHA02878

ankyrin repeat protein; Provisional

72-355

1.82e-09

ankyrin repeat protein; Provisional

Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 59.12 E-value: 1.82e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   72 IEVYNSDYKRALHEASSMGHYEcvrflicrgAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHI 151
Cdd:PHA02878   6 KSMYTDNYETILKYIEYIDHTE---------NYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  152 ACREGDPAIINHLLLAKpdiwkTKSKTGRTplhtaamhgcEDAVKillqsccyepdekdscgvtpfmDAIRNGHIAVAKL 231
Cdd:PHA02878  77 ICKEPNKLGMKEMIRSI-----NKCSVFYT----------LVAIK----------------------DAFNNRNVEIFKI 119

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  232 LLEDHQASPSAVDILGAQPLHQASVTaqEEALSFLVHHLGMDINSRATKLELTALHYAAKDGHTSTIKTLLALGADLHAR 311
Cdd:PHA02878 120 ILTNRYKNIQTIDLVYIDKKSKDDII--EAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIP 197

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 62202327  312 DAKGRSALHMACIGQHVDTVRMLLQMGL-TDTEDNTGNTARQYAI 355
Cdd:PHA02878 198 DKTNNSPLHHAVKHYNKPIVHILLENGAsTDARDKCGNTPLHISV 242

PHA03095

ankyrin-like protein; Provisional

43-256

1.92e-09

ankyrin-like protein; Provisional

Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 58.88 E-value: 1.92e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   43 KSGDTVLHYAARHGHV-DILRYLVEeLNMDIEVYNSDYKRALHE-ASSMG-HYECVRFLICRGAKVDSLKKADWTPL--M 117
Cdd:PHA03095  81 RCGFTPLHLYLYNATTlDVIKLLIK-AGADVNAKDKVGRTPLHVyLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLavL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  118 MACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACR--EGDPAIINHLLLAKPDIWKTKSkTGRTPLHTAAMHGCEDAV 195
Cdd:PHA03095 160 LKSRNANVELLRLLIDAGADVYAVDDRFRSLLHHHLQsfKPRARIVRELIRAGCDPAATDM-LGNTPLHSMATGSSCKRS 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  196 KI---------------LLQS-------------CCY------EPDEKDSCGVTPFMDAIRNGHIAVAKLLLEDHqasPS 241
Cdd:PHA03095 239 LVlplliagisinarnrYGQTplhyaavfnnpraCRRlialgaDINAVSSDGNTPLSLMVRNNNGRAVRAALAKN---PS 315

                        250
                 ....*....|....*
gi 62202327  242 AVDIlgAQPLHQASV 256
Cdd:PHA03095 316 AETV--AATLNTASV 328

PHA02875

ankyrin repeat protein; Provisional

10-145

2.77e-09

ankyrin repeat protein; Provisional

Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 58.08 E-value: 2.77e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   10 LIKAVQHGELCTVKQHL--NELADNkqtVIYthfgKSGDTVLHYAARHGHVDILRYLVEElNMDIEVYNSDYKRALHEAS 87
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLdlGKFADD---VFY----KDGMTPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAV 143

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 62202327   88 SMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDG 145
Cdd:PHA02875 144 MMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG 201

PHA02878

ankyrin repeat protein; Provisional

80-200

4.95e-09

ankyrin repeat protein; Provisional

Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 57.58 E-value: 4.95e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   80 KRALHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIAC-REGDP 158
Cdd:PHA02878 169 NTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKDY 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 62202327  159 AIINHLLLAKPDIWKTKSKTGRTPLHTAAMHgcEDAVKILLQ 200
Cdd:PHA02878 249 DILKLLLEHGVDVNAKSYILGLTALHSSIKS--ERKLKLLLE 288

Ank_4

Ankyrin repeats (many copies);

179-233

5.84e-09

Ankyrin repeats (many copies);

Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 51.51 E-value: 5.84e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 62202327   179 GRTPLHTAAMHGCEDAVKILLQSCCyEPDEKDSCGVTPFMDAIRNGHIAVAKLLL 233
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54

Ank_4

Ankyrin repeats (many copies);

45-99

6.70e-09

Ankyrin repeats (many copies);

Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 51.51 E-value: 6.70e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 62202327    45 GDTVLHYAARHGHVDILRYLVeELNMDIEVYNSDYKRALHEASSMGHYECVRFLI 99
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54

PHA02874

ankyrin repeat protein; Provisional

114-366

7.68e-09

ankyrin repeat protein; Provisional

Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 56.90 E-value: 7.68e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  114 TPLMMACTRRNLEVIQELLDYGADptlqnkdgwssfhiacregdpaiINHLLLAKPDiwktksktgrtPLHTAAMHGCED 193
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGAD-----------------------INHINTKIPH-----------PLLTAIKIGAHD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  194 AVKILL-----QSCCYEPD-EKDS------CGV----------TPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPL 251
Cdd:PHA02874  83 IIKLLIdngvdTSILPIPCiEKDMiktildCGIdvnikdaelkTFLHYAIKKGDLESIKMLFE-YGADVNIEDDNGCYPI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  252 HQASVTAQEEALSFLVHHlGMDINSRATKLElTALHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIgQHVDTV 331
Cdd:PHA02874 162 HIAIKHNFFDIIKLLLEK-GAYANVKDNNGE-SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAI 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 62202327  332 RMLLQMGLTDTEDNTGNTARQYAIKPHI-KDVFENL 366
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPCdIDIIDIL 274

PHA02874

ankyrin repeat protein; Provisional

13-195

2.12e-08

ankyrin repeat protein; Provisional

Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 55.35 E-value: 2.12e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   13 AVQHGELCTVKQHLNELADNKQTVIythfgkSGDTVLHYAARHGHVDILRYLVEElNMDIEVYNSDYKRALHEASSMGHY 92
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGADVNIEDD------NGCYPIHIAIKHNFFDIIKLLLEK-GAYANVKDNNGESPLHNAAEYGDY 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   93 ECVRFLICRGAKVDSLKKADWTPLMMACTrRNLEVIqELLDYGADPTLQNKDGWSSFHIACR-EGDPAIINHLLLAKPDI 171
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAI-ELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADI 281

                        170       180
                 ....*....|....*....|....
gi 62202327  172 wKTKSKTGRTPLHTAAMHGCEDAV 195
Cdd:PHA02874 282 -SIKDNKGENPIDTAFKYINKDPV 304

PHA02876

ankyrin repeat protein; Provisional

7-338

3.54e-08

ankyrin repeat protein; Provisional

Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 55.07 E-value: 3.54e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327    7 VKLLIKAVQHGELCTVKQHLNELADNKQTVIYTHfgksgdTVLHYAARHGH---------------------VDILRYLV 65
Cdd:PHA02876 146 MKLIKERIQQDELLIAEMLLEGGADVNAKDIYCI------TPIHYAAERGNakmvnlllsygadvniialddLSVLECAV 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   66 EELNMDIEVYNSDYKR-------ALHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNL-EVIQELLDYGAD 137
Cdd:PHA02876 220 DSKNIDTIKAIIDNRSninkndlSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGAD 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  138 PTLQNKDGWSSFHIACREG-DPAIINHLLLAKPDIWKTKSKTgRTPLHTAAMHGCEDAVKILLQSCCYEPDEKDSCGVTP 216
Cdd:PHA02876 300 VNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLY-ITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTP 378

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  217 F-MDAIRNGHIAVAKLLleDHQASPSAVDILGAQPLHQASV-TAQEEALSFLVHHlGMDINSRATKLElTALHYAAKDG- 293
Cdd:PHA02876 379 IhYAAVRNNVVIINTLL--DYGADIEALSQKIGTALHFALCgTNPYMSVKTLIDR-GANVNSKNKDLS-TPLHYACKKNc 454

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 62202327  294 HTSTIKTLLALGADLHARDAKGRSALHMAcIGQHvDTVRMLLQMG 338
Cdd:PHA02876 455 KLDVIEMLLDNGADVNAINIQNQYPLLIA-LEYH-GIVNILLHYG 497

PTZ00322

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

233-346

7.83e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.13 E-value: 7.83e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  233 LEDHQASPSAVDILGAQPLHQAsvtAQEEALSFLVHHLgmdinsraTKLELTALhyaAKDGHTSTIKTLLALGADLHARD 312
Cdd:PTZ00322  47 IDTHLEALEATENKDATPDHNL---TTEEVIDPVVAHM--------LTVELCQL---AASGDAVGARILLTGGADPNCRD 112

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 62202327  313 AKGRSALHMACIGQHVDTVRMLLQMG----LTDTEDNT 346
Cdd:PTZ00322 113 YDGRTPLHIACANGHVQVVRVLLEFGadptLLDKDGKT 150

Ank_4

Ankyrin repeats (many copies);

113-165

9.56e-08

Ankyrin repeats (many copies);

Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.04 E-value: 9.56e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 62202327   113 WTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLL 165
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54

Ank_4

Ankyrin repeats (many copies);

81-132

9.94e-08

Ankyrin repeats (many copies);

Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.04 E-value: 9.94e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 62202327    81 RALHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELL 132
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54

TRPV5-6

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...

181-321

1.52e-07

Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 53.09 E-value: 1.52e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 181 TPLHTAAMHGCEDAVKILLQSCCYEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdhqASPSAVDI-------LGAQPLHQ 253
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLME---AAPELVNEpmtsdlyQGETALHI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 254 ASVTAQEEalsfLVHHL---GMDINS-RATKLELT------------ALHYAAKDGHTSTIKTLLALGADLHARDAKGRS 317
Cdd:cd22192  96 AVVNQNLN----LVRELiarGADVVSpRATGTFFRpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNT 171


                ....
gi 62202327 318 ALHM 321
Cdd:cd22192 172 VLHI 175

PHA02874

ankyrin repeat protein; Provisional

47-199

1.67e-07

ankyrin repeat protein; Provisional

Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 52.66 E-value: 1.67e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   47 TVLHYAARHGHVDILRYLVE-ELNMDIEVYNSDYkrALHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRRNL 125
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEyGADVNIEDDNGCY--PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62202327  126 EVIQELLDYGADPTLQNKDGWSSFHIAC---REGDPAIINHLLLAKPDIwktkskTGRTPLHTAAMHGCE-DAVKILL 199
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNAIihnRSAIELLINNASINDQDI------DGSTPLHHAINPPCDiDIIDILL 275

PHA02875

ankyrin repeat protein; Provisional

180-355

5.68e-07

ankyrin repeat protein; Provisional

Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 51.15 E-value: 5.68e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  180 RTPLHTAAMHGCEDAVKILLQSCcYEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQASVTAQ 259
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIG-INPNFEIYDGISPIKLAMKFRDSEAIKLLMK-HGAIPDVKYPDIESELHDAVEEGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  260 EEALSFLVHhLGMDINSRATKLELTALHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQHVDTVRMLLQ-MG 338
Cdd:PHA02875  81 VKAVEELLD-LGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDhKA 159

                        170
                 ....*....|....*..
gi 62202327  339 LTDTEDNTGNTARQYAI 355
Cdd:PHA02875 160 CLDIEDCCGCTPLIIAM 176

PTZ00322

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

95-165

9.04e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 50.67 E-value: 9.04e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62202327   95 VRFLICRGAKVDSLKKADWTPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLL 165
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168

Ank_5

Ankyrin repeats (many copies);

114-152

9.85e-07

Ankyrin repeats (many copies);

Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.42 E-value: 9.85e-07

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 62202327   114 TPLMMACTRRNLEVIQELLDYGADPTLQNKDGWSSFHIA 152
Cdd:pfam13857  18 TPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56

Ank_5

Ankyrin repeats (many copies);

266-322

4.55e-06

Ankyrin repeats (many copies);

Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.49 E-value: 4.55e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 62202327   266 LVHHLGMDINSRATKLElTALHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMA 322
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGY-TPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56

PLN03192

Voltage-dependent potassium channel; Provisional

45-183

5.26e-06

Voltage-dependent potassium channel; Provisional

Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 48.33 E-value: 5.26e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   45 GDTVLHYAARHGHVD-ILRYLVEELNMDIEVYNSDykRALHEASSMGHYECVRFLICRGAKVDSLKKADWtpLMMACTRR 123
Cdd:PLN03192 558 GRTPLHIAASKGYEDcVLVLLKHACNVHIRDANGN--TALWNAISAKHHKIFRILYHFASISDPHAAGDL--LCTAAKRN 633

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  124 NLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLLLAKPDIWKTKSKTGRTPL 183
Cdd:PLN03192 634 DLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFSPT 693

TRPV5-6

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...

114-295

2.36e-05

Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 46.16 E-value: 2.36e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 114 TPLMMACTRRNLEVIQELLDY-GADPTLQNKDGWSSFHIACR-----------EGDPAIINHLLLAkpDIWKtksktGRT 181
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALydnleaavvlmEAAPELVNEPMTS--DLYQ-----GET 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 182 PLHTAAMHGCEDAVKILLQS-----------CCYEPDEKDSC--GVTPFMDAIRNGHIAVAKLLLEDHqASPSAVDILGA 248
Cdd:cd22192  92 ALHIAVVNQNLNLVRELIARgadvvspratgTFFRPGPKNLIyyGEHPLSFAACVGNEEIVRLLIEHG-ADIRAQDSLGN 170

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62202327 249 QPLH----QASVTAQEEALSFLvhhLGMDINSRATKLE-------LTALHYAAKDGHT 295
Cdd:cd22192 171 TVLHilvlQPNKTFACQMYDLI---LSYDKEDDLQPLDlvpnnqgLTPFKLAAKEGNI 225

PLN03192

Voltage-dependent potassium channel; Provisional

284-368

3.33e-05

Voltage-dependent potassium channel; Provisional

Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 46.01 E-value: 3.33e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  284 TALHYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQH-------------------------------VDTVR 332
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHhkifrilyhfasisdphaagdllctaakrndLTAMK 639

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 62202327  333 MLLQMGL-TDTEDNTGNTARQYAIKPHIKDVFENLAT 368
Cdd:PLN03192 640 ELLKQGLnVDSEDHQGATALQVAMAEDHVDMVRLLIM 676

PHA02741

hypothetical protein; Provisional

208-349

1.75e-04

hypothetical protein; Provisional

Pssm-ID: 165108 [Multi-domain] Cd Length: 169 Bit Score: 41.95 E-value: 1.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  208 EKDSCGVTPFMDAIRNGHIAVAKLLL-----EDHQASPSAVDILGAQPLHQASVTAQEEALSFLVHH---LGMDINSRAT 279
Cdd:PHA02741  16 EKNSEGENFFHEAARCGCFDIIARFTpfirgDCHAAALNATDDAGQMCIHIAAEKHEAQLAAEIIDHlieLGADINAQEM 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62202327  280 KLELTALHYAAKDGHTSTIKTLLAL-GADLHARDAKGRSALHMACIGQHVDTVRMLLQMGLTDTEDNTGNT 349
Cdd:PHA02741  96 LEGDTALHLAAHRRDHDLAEWLCCQpGIDLHFCNADNKSPFELAIDNEDVAMMQILREIVATSRGFSNENT 166

PHA02946

ankyin-like protein; Provisional

204-362

2.47e-04

ankyin-like protein; Provisional

Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 42.73 E-value: 2.47e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  204 YEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQASVTAQE--EALSFLVHHlGMDINSRATKL 281
Cdd:PHA02946  63 YSPNETDDDGNYPLHIASKINNNRIVAMLLT-HGADPNACDKQHKTPLYYLSGTDDEviERINLLVQY-GAKINNSVDEE 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  282 ELTALhYAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQH--VDTVRMLLQMGLTDTE-DNTGNTARQYAIKPH 358
Cdd:PHA02946 141 GCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNpkASTISWMMKLGISPSKpDHDGNTPLHIVCSKT 219


                 ....
gi 62202327  359 IKDV 362
Cdd:PHA02946 220 VKNV 223

Ank

pfam00023

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...

113-143

4.29e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.

Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.27 E-value: 4.29e-04

                          10        20        30
                  ....*....|....*....|....*....|..
gi 62202327   113 WTPLMMACTRR-NLEVIQELLDYGADPTLQNK 143
Cdd:pfam00023   3 NTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34

PHA02875

ankyrin repeat protein; Provisional

49-165

4.75e-04

ankyrin repeat protein; Provisional

Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 41.90 E-value: 4.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   49 LHYAARHGHVdilrYLVEELnMDIEVYNSD--YKRA---LHEASSMGHYECVRFLICRGAKVDSLKKADWTPLMMACTRR 123
Cdd:PHA02875  72 LHDAVEEGDV----KAVEEL-LDLGKFADDvfYKDGmtpLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 62202327  124 NLEVIQELLDYGADPTLQNKDGWSSFHIACREGDPAIINHLL 165
Cdd:PHA02875 147 DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188

PLN03192

Voltage-dependent potassium channel; Provisional

264-355

5.09e-04

Voltage-dependent potassium channel; Provisional

Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 42.16 E-value: 5.09e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  264 SFLVHHLGM-DINSRATKLELTALH----------YAAKDGHTSTIKTLLALGADLHARDAKGRSALHMACIGQHVDTVR 332
Cdd:PLN03192 496 NFLQHHKELhDLNVGDLLGDNGGEHddpnmasnllTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVL 575

                         90       100
                 ....*....|....*....|....
gi 62202327  333 MLLQMGLT-DTEDNTGNTARQYAI 355
Cdd:PLN03192 576 VLLKHACNvHIRDANGNTALWNAI 599

ANK

smart00248

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...

112-140

8.06e-04

Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 8.06e-04

                           10        20
                   ....*....|....*....|....*....
gi 62202327    112 DWTPLMMACTRRNLEVIQELLDYGADPTL 140
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30

ANK

smart00248

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...

45-67

1.09e-03

Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.03 E-value: 1.09e-03

                           10        20
                   ....*....|....*....|...
gi 62202327     45 GDTVLHYAARHGHVDILRYLVEE 67
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDK 24

TRPV5-6

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...

42-165

1.17e-03

Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 40.77 E-value: 1.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  42 GKSGDTVLHYAARHGHVDILRYLVEE----LNMDI--EVYNSdyKRALHEASSMGHYECVRFLICRGAKVDSlKKADWT- 114
Cdd:cd22192  48 GALGETALHVAALYDNLEAAVVLMEAapelVNEPMtsDLYQG--ETALHIAVVNQNLNLVRELIARGADVVS-PRATGTf 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327 115 --------------PLMMACTRRNLEVIQELLDYGADP------------------------------------------ 138
Cdd:cd22192 125 frpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIraqdslgntvlhilvlqpnktfacqmydlilsydkeddlqpl 204

                       170       180
                ....*....|....*....|....*...
gi 62202327 139 -TLQNKDGWSSFHIACREGDPAIINHLL 165
Cdd:cd22192 205 dLVPNNQGLTPFKLAAKEGNIVMFQHLV 232

PTZ00322

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

183-278

1.18e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 41.04 E-value: 1.18e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  183 LHTAAMHGCE-----DAV--KILLQSCCyEPDEKDSCGVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQAS 255
Cdd:PTZ00322  79 AHMLTVELCQlaasgDAVgaRILLTGGA-DPNCRDYDGRTPLHIACANGHVQVVRVLLE-FGADPTLLDKDGKTPLELAE 156

                         90       100
                 ....*....|....*....|...
gi 62202327  256 VTAQEEALSFLVHHLGMDINSRA 278
Cdd:PTZ00322 157 ENGFREVVQLLSRHSQCHFELGA 179

Ank_4

Ankyrin repeats (many copies);

213-267

1.50e-03

Ankyrin repeats (many copies);

Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.48 E-value: 1.50e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 62202327   213 GVTPFMDAIRNGHIAVAKLLLEdHQASPSAVDILGAQPLHQASVTAQEEALSFLV 267
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLLL 54

Ank

pfam00023

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...

284-312

1.54e-03

Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.73 E-value: 1.54e-03

                          10        20        30
                  ....*....|....*....|....*....|
gi 62202327   284 TALHYAA-KDGHTSTIKTLLALGADLHARD 312
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNARD 33

Ank_3

pfam13606

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...

113-138

1.95e-03

Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 35.31 E-value: 1.95e-03

                          10        20
                  ....*....|....*....|....*.
gi 62202327   113 WTPLMMACTRRNLEVIQELLDYGADP 138
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADI 28

TRPV3

cd22194

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...

11-190

1.99e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.

Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 40.13 E-value: 1.99e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  11 IKAVQHGELCTVKQHLNELADNKQTViythfgksgDTVLHYAARHGHVDILrylveelnMDIEVYNSDYK--RALHEASS 88
Cdd:cd22194  88 LTASDTGKTCLMKALLNINENTKEIV---------RILLAFAEENGILDRF--------INAEYTEEAYEgqTALNIAIE 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327  89 MGHYECVRFLICRGAKVDSLKKADW--------------TPLMMACTRRNLEVIQELLDYGADP-TLQNKDGWSSFHIAC 153
Cdd:cd22194 151 RRQGDIVKLLIAKGADVNAHAKGVFfnpkykhegfyfgeTPLALAACTNQPEIVQLLMEKESTDiTSQDSRGNTVLHALV 230

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 62202327 154 REGDPA---------IINHLLLA--KPDIWKTKSKTGRTPLHTAAMHG 190
Cdd:cd22194 231 TVAEDSktqndfvkrMYDMILLKseNKNLETIRNNEGLTPLQLAAKMG 278

Ank_4

Ankyrin repeats (many copies);

43-65

3.81e-03

Ankyrin repeats (many copies);

Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 35.33 E-value: 3.81e-03

                          10        20
                  ....*....|....*....|...
gi 62202327    43 KSGDTVLHYAARHGHVDILRYLV 65
Cdd:pfam13637  32 GNGETALHFAASNGNVEVLKLLL 54

Ank_5

Ankyrin repeats (many copies);

40-86

3.96e-03

Ankyrin repeats (many copies);

Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 35.40 E-value: 3.96e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 62202327    40 HFGKSGDTVLHYAARHGHVDILRYLVEElNMDIEVYNSDYKRALHEA 86
Cdd:pfam13857  11 RLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDLA 56

Ank_3

pfam13606

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...

45-66

4.38e-03

Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 34.54 E-value: 4.38e-03

                          10        20
                  ....*....|....*....|..
gi 62202327    45 GDTVLHYAARHGHVDILRYLVE 66
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLE 23

trp

TIGR00870

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...

217-332

6.03e-03

Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 38.52 E-value: 6.03e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62202327   217 FMDAIRNGHIAVAKLLLEdHQASPSAVDILgaqpLHQAS---VTAQEEALSFLVHH--------LGMDINSRATKLELTA 285
Cdd:TIGR00870  57 FVAAIENENLELTELLLN-LSCRGAVGDTL----LHAISleyVDAVEAILLHLLAAfrksgpleLANDQYTSEFTPGITA 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 62202327   286 LHYAAKDGHTSTIKTLLALGADLHARdAKGRSALhmacIGQHVDTVR 332
Cdd:TIGR00870 132 LHLAAHRQNYEIVKLLLERGASVPAR-ACGDFFV----KSQGVDSFY 173

Ank_5