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Conserved domains on  [gi|38649260|gb|AAH63302|]
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Niemann-Pick disease, type C1 [Homo sapiens]

Protein Classification

Niemann-Pick C type protein family( domain architecture ID 11489961)

Niemann-Pick C (NPC) type protein family is essential for sterol homeostasis that drive sterol integration into the lysosomal membrane before redistribution to other cellular membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
25-1252 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1930.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260     25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCpGFFFGNVS--LCCDVRQLQTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    103 NLLNLFCELTCSPRQSQFLNVTATEDyvdpvtNQTKTNVKELQYYVGQGFANAMYNACRDVEAPSSNDKALGLLCGKDAD 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    183 ACNATNWIEYMFNKDNGQAPFTITPVFSDFPV-HGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    262 ILGLDAMYVIMWITYMAFLLVFFG--AFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLF 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    340 TRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHi 419
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    420 yqpypsgadVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNtnCTILSVLNYFQNSHSVLDHKK 499
Cdd:TIGR00917  393 ---------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    500 GDDFFVyADYHTHFLYCVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQR 579
Cdd:TIGR00917  462 YDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    580 AQAWEKEFINFVKNYKNPNL--TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLG 657
Cdd:TIGR00917  531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    658 IAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGE---------TLDQQLGRVL 728
Cdd:TIGR00917  611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRAL 690
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    729 GEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDG- 807
Cdd:TIGR00917  691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSi 770
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    808 ----TSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL 883
Cdd:TIGR00917  771 saekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    884 HAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQifnaaqLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNIT 963
Cdd:TIGR00917  851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    964 DQFCNasVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILlGHGTRVGATYFMTYHT 1043
Cdd:TIGR00917  925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQ-GYATIIQASSFRTYHT 1001
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1044 VLQTSADFIDALKKARLIASNVTEtmginGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWS 1123
Cdd:TIGR00917 1002 PLNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALS 1076
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1124 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGIT 1203
Cdd:TIGR00917 1077 VVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGIT 1156
                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*....
gi 38649260   1204 LTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1252
Cdd:TIGR00917 1157 LTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
25-1252 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1930.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260     25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCpGFFFGNVS--LCCDVRQLQTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    103 NLLNLFCELTCSPRQSQFLNVTATEDyvdpvtNQTKTNVKELQYYVGQGFANAMYNACRDVEAPSSNDKALGLLCGKDAD 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    183 ACNATNWIEYMFNKDNGQAPFTITPVFSDFPV-HGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    262 ILGLDAMYVIMWITYMAFLLVFFG--AFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLF 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    340 TRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHi 419
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    420 yqpypsgadVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNtnCTILSVLNYFQNSHSVLDHKK 499
Cdd:TIGR00917  393 ---------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    500 GDDFFVyADYHTHFLYCVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQR 579
Cdd:TIGR00917  462 YDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    580 AQAWEKEFINFVKNYKNPNL--TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLG 657
Cdd:TIGR00917  531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    658 IAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGE---------TLDQQLGRVL 728
Cdd:TIGR00917  611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRAL 690
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    729 GEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDG- 807
Cdd:TIGR00917  691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSi 770
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    808 ----TSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL 883
Cdd:TIGR00917  771 saekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    884 HAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQifnaaqLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNIT 963
Cdd:TIGR00917  851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    964 DQFCNasVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILlGHGTRVGATYFMTYHT 1043
Cdd:TIGR00917  925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQ-GYATIIQASSFRTYHT 1001
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1044 VLQTSADFIDALKKARLIASNVTEtmginGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWS 1123
Cdd:TIGR00917 1002 PLNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALS 1076
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1124 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGIT 1203
Cdd:TIGR00917 1077 VVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGIT 1156
                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*....
gi 38649260   1204 LTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1252
Cdd:TIGR00917 1157 LTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
23-267 5.17e-94

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 301.45  E-value: 5.17e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260     23 QSCVWYGECGI-AYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCF 101
Cdd:pfam16414    1 GRCAWYGECGKkSLFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    102 YNLLNLFCELTCSPRQSQFLNVTATEdyvdpVTNQTKTNVKELQYYVGQGFANAMYNACRDVEAPSSNDKALGLLCGKda 181
Cdd:pfam16414   81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGG-- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    182 dACNATNWIEYMFNKDNGQAPFTITPVF-SDFPVHGMEPMNNATKGCDESVDEvTAPCSCQDCSIVCGPKPQP-PPPPAP 259
Cdd:pfam16414  154 -ACNYTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSCPPPPQLpPPPHGP 231

                   ....*...
gi 38649260    260 WTILGLDA 267
Cdd:pfam16414  232 CKVGGLDG 239
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
336-1259 2.21e-34

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 142.31  E-value: 2.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  336 RRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDlWSAPSSQARLEKEYFDQHFGPffrTEQLIIraplt 415
Cdd:COG1033    1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  416 dkhIYQPYPsgaDVpfgppLDIQILHQVLDLQIAIENItasydnETVTlqdiclaplspyntncTILSVLNYFQnshsvl 495
Cdd:COG1033   72 ---AVEGKD---DI-----FTPETLEALRELTEELEEI------PGVD----------------SVTSLTNVRA------ 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  496 DHKKGDDFFVYADYHTHFLYCVRAPASLNDtSLLHDPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFpvnNYYN 572
Cdd:COG1033  113 TEGTEDGLTVEPLIPDELPASPEELAELRE-KVLSSP----------------LYVGRLVSPdgkATLIVVTL---DPDP 172
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  573 DTEKLQRAQAWEkEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVV-ISYAIMFLYISLALGHikscrrllvd 651
Cdd:COG1033  173 LSSDLDRKEVVA-EIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRS---------- 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  652 skVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVDNIFILVQAYqRDERLQGETLDQQLGRVLGEV 731
Cdd:COG1033  242 --LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRY-REERRKGLDKREALREALRKL 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  732 APSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQIT---CFVSLLGLDIKRQEKNRldifccvrgaedgt 808
Cdd:COG1033  318 GPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTllpALLSLLPRPKPKTRRLK-------------- 383
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  809 svqaSESCLFRFFKNsyspllLKDWMRP---IVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDS-YMVDyFKSISQYLH 884
Cdd:COG1033  384 ----KPPELGRLLAK------LARFVLRrpkVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpIRQD-LDFIEENFG 452
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  885 AGPPVYFVLEEGHDYtsskgqnmvcggmGCNNDSLVQQIFNAAQ-LDNYTRIGFAPSswIDDYFDWVkpqssccrvdnit 963
Cdd:COG1033  453 GSDPLEVVVDTGEPD-------------GLKDPEVLKEIDRLQDyLESLPEVGKVLS--LADLVKEL------------- 504
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  964 dqfcNASVVDPAcvrcrpltPEGKQRPQGGDFMRFLPMFLSDNPNpkcgkgghaaySSAVNILLGHGTRVGATYFMTYHT 1043
Cdd:COG1033  505 ----NQALNEGD--------PKYYALPESRELLAQLLLLLSSPPG-----------DDLSRFVDEDYSAARVTVRLKDLD 561
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1044 VlQTSADFIDALKKArlIASNvtetmgINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGcELWS 1123
Cdd:COG1033  562 S-EEIKALVEEVRAF--LAEN------FPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRL 631
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1124 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMK--GSRVERAEEALAHMGSSV-FS 1200
Cdd:COG1033  632 GLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRkgGDLEEAIRRALRTTGKAIlFT 711
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38649260 1201 GITLtkFGGIVVLAFAKSQIFQIFYFRMYLAMV--LLGAthgLIFLPVLLSYIGPSVNKAK 1259
Cdd:COG1033  712 SLTL--AAGFGVLLFSSFPPLADFGLLLALGLLvaLLAA---LLLLPALLLLLDPRIAKKR 767
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
1046-1166 1.22e-04

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 46.55  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  1046 QTSADFIDALKKARLIASNVTETMGingSAYRVfpysvfYVFYEQYLTI---IDDTIFNLGVSLGAIFLVTMVLLGcELW 1122
Cdd:NF033617  286 QPGANPIEVADEIRALLPELQETLP---KNIKV------NVLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLR 355
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 38649260  1123 SAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1166
Cdd:NF033617  356 ATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
25-1252 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1930.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260     25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCpGFFFGNVS--LCCDVRQLQTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    103 NLLNLFCELTCSPRQSQFLNVTATEDyvdpvtNQTKTNVKELQYYVGQGFANAMYNACRDVEAPSSNDKALGLLCGKDAD 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    183 ACNATNWIEYMFNKDNGQAPFTITPVFSDFPV-HGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    262 ILGLDAMYVIMWITYMAFLLVFFG--AFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLF 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    340 TRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHi 419
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    420 yqpypsgadVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNtnCTILSVLNYFQNSHSVLDHKK 499
Cdd:TIGR00917  393 ---------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    500 GDDFFVyADYHTHFLYCVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQR 579
Cdd:TIGR00917  462 YDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    580 AQAWEKEFINFVKNYKNPNL--TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLG 657
Cdd:TIGR00917  531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    658 IAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGE---------TLDQQLGRVL 728
Cdd:TIGR00917  611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRAL 690
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    729 GEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDG- 807
Cdd:TIGR00917  691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSi 770
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    808 ----TSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL 883
Cdd:TIGR00917  771 saekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    884 HAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQifnaaqLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNIT 963
Cdd:TIGR00917  851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    964 DQFCNasVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILlGHGTRVGATYFMTYHT 1043
Cdd:TIGR00917  925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQ-GYATIIQASSFRTYHT 1001
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1044 VLQTSADFIDALKKARLIASNVTEtmginGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWS 1123
Cdd:TIGR00917 1002 PLNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALS 1076
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1124 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGIT 1203
Cdd:TIGR00917 1077 VVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGIT 1156
                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*....
gi 38649260   1204 LTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1252
Cdd:TIGR00917 1157 LTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
23-267 5.17e-94

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 301.45  E-value: 5.17e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260     23 QSCVWYGECGI-AYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCF 101
Cdd:pfam16414    1 GRCAWYGECGKkSLFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    102 YNLLNLFCELTCSPRQSQFLNVTATEdyvdpVTNQTKTNVKELQYYVGQGFANAMYNACRDVEAPSSNDKALGLLCGKda 181
Cdd:pfam16414   81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGG-- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    182 dACNATNWIEYMFNKDNGQAPFTITPVF-SDFPVHGMEPMNNATKGCDESVDEvTAPCSCQDCSIVCGPKPQP-PPPPAP 259
Cdd:pfam16414  154 -ACNYTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSCPPPPQLpPPPHGP 231

                   ....*...
gi 38649260    260 WTILGLDA 267
Cdd:pfam16414  232 CKVGGLDG 239
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
524-1249 7.97e-75

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 265.76  E-value: 7.97e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    524 NDTSLLHDPCLGTFGGPVFPWLVLGG---YDDQNYNNATALVITFPVNnyYNDTEKLQRAQAWEKEFINFVKN-YKNPNL 599
Cdd:pfam02460  117 NTRIDITYPIMPVLGTPIYLGPHFGGvdfEPPGNISYAKAIVLWYFLK--FDEEEVEEDSKEWEDELSQLLHNkYASEHI 194
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    600 TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIG 679
Cdd:pfam02460  195 QFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMG 274
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    680 LPLTLIVIeVIPFLVLAVGVDNIFILVQAYQRDERLQgeTLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHT 759
Cdd:pfam02460  275 FPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATL--SVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQL 351
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    760 FSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRG----AEDGTSV----QASESCLFRFFKNSYSPLLLK 831
Cdd:pfam02460  352 FCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSspqrIDSEGSEpdksHNIEQLKSRFFLDIYCPFLLN 431
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    832 DWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL-HAGPPVYFVLEEGHDYTSSKgqnmvcg 910
Cdd:pfam02460  432 PSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNNPPNLTIPE------- 504
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    911 gmgcNNDSLvQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQssccrvdnitdqfcNASVVDpacvrcrpltpEGKQRP 990
Cdd:pfam02460  505 ----SRDRM-NEMVDEFENTPYSLGPNSTLFWLREYENFLSTL--------------NMEEEE-----------DEEKEW 554
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    991 QGGDfmrfLPMFLSDNPNPKCGKGGHAAYSsavnillghGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNvtetmg 1070
Cdd:pfam02460  555 SYGN----LPSFLKAPGNSHWAGDLVWDDN---------TTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIADQ------ 615
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1071 ingsaYRVFPYSVF---YVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCAtIAMVLVNMFGVMWLWGI 1147
Cdd:pfam02460  616 -----YPEFNVTVFdedAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLA-IASIDIGVFGFLSLWGV 689
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1148 SLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTkFGGIVVLAFAKSQIFQIFYFR 1227
Cdd:pfam02460  690 DLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVFFKT 768
                          730       740
                   ....*....|....*....|..
gi 38649260   1228 MYLaMVLLGATHGLIFLPVLLS 1249
Cdd:pfam02460  769 VFL-VVAIGLLHGLFILPIILS 789
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
649-803 6.25e-65

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 216.68  E-value: 6.25e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    649 LVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGEtlDQQLGRVL 728
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDV--SERIAEAL 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38649260    729 GEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRG 803
Cdd:pfam12349   79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
581-1253 3.13e-64

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 239.01  E-value: 3.13e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    581 QAWEKEFINFVKNY--KNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALghiksCRRLLVDSKVSLGI 658
Cdd:TIGR00918  357 EAWQRNFSEEVQQSlpKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTM-----LRWDCAKSQGSVGL 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    659 AGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQrdERLQGETLDQQLGRVLGEVAPSMFLS 738
Cdd:TIGR00918  432 AGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFS--ETGQNIPFEERTGECLKRTGASVVLT 509
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    739 SFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGA-------------- 804
Cdd:TIGR00918  510 SISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSPcsarviqiepqaya 589
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    805 --------------------EDGTSVQASESC------------------------------------------------ 816
Cdd:TIGR00918  590 dgsappvysshmqstvqlrtEYDPGTQHYYTTneprshlsvqpsdplscqspdiagstrdllsqfedskaaclslpcarw 669
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    817 -LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLhAGPPVYFVLEE 895
Cdd:TIGR00918  670 tLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYF-SFYNMYAVTQG 748
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    896 GHDYTSSKgqnmvcggmgcnndslvQQIFNAAQldNYTRI--------GFAPSSWIDDYFDWV----KPQSSCCRVDNIT 963
Cdd:TIGR00918  749 NFDYPTQQ-----------------QLLYDLHQ--SFSSVkyvlkednGQLPRMWLHYFRDWLqglqKAFDEDWRDGRIT 809
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    964 -DQFCNASvvDPACVRCRPLTPEGkQRPQGGDFMRFLPMFLSDNP---NPKCGKGGHAAYSSavNILLGHGTRVGATY-- 1037
Cdd:TIGR00918  810 kENYRNGS--DDAVLAYKLLVQTG-HRDKPVDKEQLTTQRLVNADgiiNPNAFYIYLSAWVS--NDPVAYAASQANIYph 884
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1038 ----------------------------FMTYHTVLQTSADFIDALKKARLIASNVTetmginGSAYRVFPYSVFYVFYE 1089
Cdd:TIGR00918  885 ppewlhdkndydpenlripaaepleyaqFPFYLNGLRETSQFVEAIEHVRAICNNYE------GFGLPSYPSGYPFLFWE 958
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1090 QYLTIIDDTIFNLGVSLGAIFLVTMVLLgCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCS 1169
Cdd:TIGR00918  959 QYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTV 1037
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1170 HITRAFTVSMkGSRVERAEEALAHMGSSVFSGITLTKFGgivVLAFAKSQI-FQIFYFRMYLAMV-LLGATHGLIFLPVL 1247
Cdd:TIGR00918 1038 HIALGFLTAI-GDRNRRAVLALEHMFAPVLDGALSTLLG---VLMLAGSEFdFIVRYFFAVLAVLtCLGVLNGLVLLPVL 1113

                   ....*.
gi 38649260   1248 LSYIGP 1253
Cdd:TIGR00918 1114 LSMFGP 1119
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
336-1259 2.21e-34

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 142.31  E-value: 2.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  336 RRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDlWSAPSSQARLEKEYFDQHFGPffrTEQLIIraplt 415
Cdd:COG1033    1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  416 dkhIYQPYPsgaDVpfgppLDIQILHQVLDLQIAIENItasydnETVTlqdiclaplspyntncTILSVLNYFQnshsvl 495
Cdd:COG1033   72 ---AVEGKD---DI-----FTPETLEALRELTEELEEI------PGVD----------------SVTSLTNVRA------ 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  496 DHKKGDDFFVYADYHTHFLYCVRAPASLNDtSLLHDPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFpvnNYYN 572
Cdd:COG1033  113 TEGTEDGLTVEPLIPDELPASPEELAELRE-KVLSSP----------------LYVGRLVSPdgkATLIVVTL---DPDP 172
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  573 DTEKLQRAQAWEkEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVV-ISYAIMFLYISLALGHikscrrllvd 651
Cdd:COG1033  173 LSSDLDRKEVVA-EIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRS---------- 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  652 skVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVDNIFILVQAYqRDERLQGETLDQQLGRVLGEV 731
Cdd:COG1033  242 --LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRY-REERRKGLDKREALREALRKL 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  732 APSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQIT---CFVSLLGLDIKRQEKNRldifccvrgaedgt 808
Cdd:COG1033  318 GPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTllpALLSLLPRPKPKTRRLK-------------- 383
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  809 svqaSESCLFRFFKNsyspllLKDWMRP---IVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDS-YMVDyFKSISQYLH 884
Cdd:COG1033  384 ----KPPELGRLLAK------LARFVLRrpkVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpIRQD-LDFIEENFG 452
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  885 AGPPVYFVLEEGHDYtsskgqnmvcggmGCNNDSLVQQIFNAAQ-LDNYTRIGFAPSswIDDYFDWVkpqssccrvdnit 963
Cdd:COG1033  453 GSDPLEVVVDTGEPD-------------GLKDPEVLKEIDRLQDyLESLPEVGKVLS--LADLVKEL------------- 504
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  964 dqfcNASVVDPAcvrcrpltPEGKQRPQGGDFMRFLPMFLSDNPNpkcgkgghaaySSAVNILLGHGTRVGATYFMTYHT 1043
Cdd:COG1033  505 ----NQALNEGD--------PKYYALPESRELLAQLLLLLSSPPG-----------DDLSRFVDEDYSAARVTVRLKDLD 561
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1044 VlQTSADFIDALKKArlIASNvtetmgINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGcELWS 1123
Cdd:COG1033  562 S-EEIKALVEEVRAF--LAEN------FPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRL 631
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1124 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMK--GSRVERAEEALAHMGSSV-FS 1200
Cdd:COG1033  632 GLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRkgGDLEEAIRRALRTTGKAIlFT 711
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38649260 1201 GITLtkFGGIVVLAFAKSQIFQIFYFRMYLAMV--LLGAthgLIFLPVLLSYIGPSVNKAK 1259
Cdd:COG1033  712 SLTL--AAGFGVLLFSSFPPLADFGLLLALGLLvaLLAA---LLLLPALLLLLDPRIAKKR 767
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
335-783 4.37e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 80.29  E-value: 4.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  335 LRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDlWSAPSSQARLEKEYFDQHFGPFFRTEqLIIRAPl 414
Cdd:COG1033  388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFGGSDPLE-VVVDTG- 464
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  415 TDKHIYQPypsgadvpfgppldiQILHQVLDLQIAIENItasydnETVTlqdiclaplspyntncTILSVLNYFQNSHSV 494
Cdd:COG1033  465 EPDGLKDP---------------EVLKEIDRLQDYLESL------PEVG----------------KVLSLADLVKELNQA 507
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  495 LDhkkGDDFFVYAdyhthflycvrapasLNDTSLLHDPCLGTFGGPvfPWLVLGGYDDQNYNNAtalVITFPVNNyyNDT 574
Cdd:COG1033  508 LN---EGDPKYYA---------------LPESRELLAQLLLLLSSP--PGDDLSRFVDEDYSAA---RVTVRLKD--LDS 562
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  575 EKLQRAQAWEKEFINfvKNYKNPNLTISFTAERSIEDELNRESDSD-VFTVVISYAIMFLYISLALGhikscrrllvdsK 653
Cdd:COG1033  563 EEIKALVEEVRAFLA--ENFPPDGVEVTLTGSAVLFAAINESVIESqIRSLLLALLLIFLLLLLAFR------------S 628
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  654 VSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPfLVLAVGVDN-IFILvqAYQRDERLQGETLDQQLGRVLGEVA 732
Cdd:COG1033  629 LRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYtIHFL--SRYREERRKGGDLEEAIRRALRTTG 705
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 38649260  733 PSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLL 783
Cdd:COG1033  706 KAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALL 756
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1094-1260 2.78e-12

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 71.43  E-value: 2.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1094 IIDDTIFNLGVSLGAIFLVTMVLLGCeLWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITR 1173
Cdd:COG1033  216 IQSDLAIFFPLALLLILLLLFLFFRS-LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLN 294
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1174 AFTVSMK--GSRVERAEEALAHMGSSVFSGiTLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHgLIFLPVLLSYI 1251
Cdd:COG1033  295 RYREERRkgLDKREALREALRKLGPPVLLT-SLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS-LTLLPALLSLL 372

                 ....*....
gi 38649260 1252 GPSVNKAKS 1260
Cdd:COG1033  373 PRPKPKTRR 381
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
571-800 1.13e-09

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 62.93  E-value: 1.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    571 YNDTEKlqraqawEKEFINFVKNYK---NPNLTISFTAERSIEDELNResdsdvfTVVISYAIMFLYIslalghikscrr 647
Cdd:TIGR00921  157 YNDVER-------SLERTNPPSGKFldvTGSPAINYDIEREFGKDMGT-------TMAISGILVVLVL------------ 210
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    648 LLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPfLVLAVGVDNIFILVQAYQrDERLQGETLDQQLGRV 727
Cdd:TIGR00921  211 LLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDYGIQTLNRYE-EERDIGRAKGEAIVTA 288
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38649260    728 LGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
Cdd:TIGR00921  289 VRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVKKEIIAI 361
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
658-785 6.31e-09

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 59.23  E-value: 6.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    658 IAGILIVLS---SVACSLG---VFSYI-GLPLTLIVIEVIPFLVLAVGVD-NIFiLVQAYqRDERLQGETLDQQLGRVLG 729
Cdd:pfam03176  167 VAALLPLLTvglSLGAAQGlvaILAHIlGIGLSTFALNLLVVLLIAVGTDyALF-LVSRY-REELRAGEDREEAVIRAVR 244
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 38649260    730 EVAPSMFLSSFseTVAFFLGALSV--MPAVHTFSLFAGLAVFIDFLLQITCFVSLLGL 785
Cdd:pfam03176  245 GTGKVVTAAGL--TVAIAMLALSFarLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1095-1259 3.89e-08

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 58.19  E-value: 3.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1095 IDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISV-------Ef 1167
Cdd:COG0841  330 IEEVVKTLLEAILLVVLVVFLFLR-SWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVddaivvvE- 407
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1168 csHITRafTVSMKGSRVERAEEALAHMGSSVFSgITLTKfggIVV---LAFAKSQIFQIFYfrmYLAMVLLGAT-----H 1239
Cdd:COG0841  408 --NIER--HMEEGLSPLEAAIKGAREVAGAVIA-STLTL---VAVflpLAFMGGITGQLFR---QFALTVAIALlislfV 476
                        170       180
                 ....*....|....*....|
gi 38649260 1240 GLIFLPVLLSYIGPSVNKAK 1259
Cdd:COG0841  477 ALTLTPALCARLLKPHPKGK 496
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
619-792 2.87e-06

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 51.78  E-value: 2.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    619 SDVFTVVISYAIMFLYISLALGHIkscRRLlvDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIViEVIPFLVLAVG 698
Cdd:TIGR00920   60 SDVIVMTITRCIAVLYIYYQFCNL---RQL--GSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLN-EALPFFLLLID 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    699 VDNIFILVQaYQRDERLQGETLDqQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITC 778
Cdd:TIGR00920  134 LSKASALAK-FALSSNSQDEVRD-NIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMTF 211
                          170
                   ....*....|....*..
gi 38649260    779 F---VSLLgLDIKRQEK 792
Cdd:TIGR00920  212 FpacLSLV-LELSRSGR 227
COG4258 COG4258
Predicted exporter [General function prediction only];
626-774 9.43e-06

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 50.24  E-value: 9.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  626 ISYAIMFLYISLALGHIkscRRLLVdskvslgiagILIV-LSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVD-NIF 703
Cdd:COG4258  647 LALLLILLLLLLRLRSL---RRALR----------VLLPpLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyALF 712
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38649260  704 ILVQAYQRDERLqgetldqqlgRVLgevaPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLL 774
Cdd:COG4258  713 FTEGLLDKGELA----------RTL----LSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLL 769
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
1079-1249 1.04e-05

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 49.99  E-value: 1.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1079 FPYSVFY-VFYEQYLTI---IDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSL 1154
Cdd:pfam00873  310 FPQGVEIvVVYDTTPFIrasIEEVVKTLLEAIVLVILVMFLFLQ-NWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTL 388
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1155 VNLVMSCGISV-------EFCSHITRA-----FTVSMKGSR-VERAEEALAHMGSSVFsgITLTKFGGIVvlafakSQIF 1221
Cdd:pfam00873  389 GGLVLAIGLVVddaivvvENIERVLEEnglkpLEAAYKSMGeIGGALVAIALVLSAVF--LPILFLGGLT------GRIF 460
                          170       180
                   ....*....|....*....|....*...
gi 38649260   1222 QIFYFRMYLAMvLLGATHGLIFLPVLLS 1249
Cdd:pfam00873  461 RQFAITIVLAI-LLSVLVALTLTPALCA 487
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1095-1215 5.80e-05

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 47.72  E-value: 5.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1095 IDDTIFNLGVSL--GAIfLVTMVL---LGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCG------- 1162
Cdd:COG3696  330 IDRAIHTVTKNLleGAL-LVILVLflfLG-NLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGiivdgav 407
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 38649260 1163 ISVEFC-SHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITltkfggIVVLAF 1215
Cdd:COG3696  408 VMVENIlRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF 455
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
1046-1166 1.22e-04

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 46.55  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  1046 QTSADFIDALKKARLIASNVTETMGingSAYRVfpysvfYVFYEQYLTI---IDDTIFNLGVSLGAIFLVTMVLLGcELW 1122
Cdd:NF033617  286 QPGANPIEVADEIRALLPELQETLP---KNIKV------NVLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLR 355
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 38649260  1123 SAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1166
Cdd:NF033617  356 ATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
COG4258 COG4258
Predicted exporter [General function prediction only];
1087-1260 1.25e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 46.38  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1087 FYEQYLtiiDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1166
Cdd:COG4258  633 LFGRYR---NDALWLLLLALLLILLLLLLRLR-SLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGID 708
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260 1167 FCSHITRAFTvsmkgsrveRAEEALAHMGSSVFSGI-TLTKFGgivVLAFAKSQIFQIFYfrmylAMVLLGathglIFLP 1245
Cdd:COG4258  709 YALFFTEGLL---------DKGELARTLLSILLAALtTLLGFG---LLAFSSTPALRSFG-----LTVLLG-----ILLA 766
                        170
                 ....*....|....*
gi 38649260 1246 VLLSYIGPSVNKAKS 1260
Cdd:COG4258  767 LLLAPLLAPRRRPRR 781
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
597-785 3.64e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.83  E-value: 3.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    597 PNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALghiksCRRLLVdskvslGIAGILIVLSSVACSLGVFS 676
Cdd:TIGR00921  545 PGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAV-----FRNPIK------AVFPLIAIGSGILWAIGLMG 613
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260    677 YIGLPLTLIVIEVIPfLVLAVGVDNIFILVQAY--QRDERLQGETLDQQLGRVlgevAPSMFLSSFseTVAFFLGAL--S 752
Cdd:TIGR00921  614 LRGIPSFLAMATTIS-IILGLGMDYSIHLAERYfeERKEHGPKEAITHTMERT----GPGILFSGL--TTAGGFLSLllS 686
                          170       180       190
                   ....*....|....*....|....*....|...
gi 38649260    753 VMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGL 785
Cdd:TIGR00921  687 HFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
597-777 4.06e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 44.76  E-value: 4.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  597 PNLTISFTAERSIEDELNRESDSD-----VFTVVISYAIMFLyislALGhikscrrllvdskvSLGIAG--ILIVLSSVA 669
Cdd:COG2409  147 PGLTVYVTGPAALAADLNEAFEEDlgraeLITLPVALVVLLL----VFR--------------SLVAALlpLLTAGLAVG 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260  670 CSLGVFSYIG--LPLTLIVIEVIPFLVLAVGVD-NIFILvqAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFseTVAF 746
Cdd:COG2409  209 VALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLV--SRYREELRAGEDREEAVARAVATAGRAVLFSGL--TVAI 284
                        170       180       190
                 ....*....|....*....|....*....|...
gi 38649260  747 FLGALSV--MPAVHTFSLFAGLAVFIDFLLQIT 777
Cdd:COG2409  285 ALLGLLLagLPFLRSMGPAAAIGVAVAVLAALT 317
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
1100-1276 2.40e-03

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 42.13  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1100 FNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNM-FGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAF--T 1176
Cdd:TIGR00921  195 MGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYeeE 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38649260   1177 VSMKGSRVERAEEALAHMGSSVFSGITLTKFGgivVLAFAKSQIFQIFYFRMYLAM-VLLGATHGLIFLPVLLSYIGPSV 1255
Cdd:TIGR00921  275 RDIGRAKGEAIVTAVRRTGRAVLIALLTTSAG---FAALALSEFPMVSEFGLGLVAgLITAYLLTLLVLPALLQSIDIGR 351
                          170       180
                   ....*....|....*....|.
gi 38649260   1256 NKAKSCATEERYKGTERERLL 1276
Cdd:TIGR00921  352 EKVKKEIIAIGGKSSEIEEEL 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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