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Conserved domains on  [gi|133777064|gb|AAH58640|]
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Zinc finger protein 710 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-540 2.90e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 363 FSTLTQLKRHLASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLKQHSLTHKGV 435
Cdd:COG5048  270 SQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 436 KEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FKCKVCGKSFN 504
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 133777064 505 RMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 540
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.15e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 133777064  284 HLQTHLLTHQGTRPHKCQVCHKAFTQ 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 3.75e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*.
gi 133777064  312 HLKRHMLLHSEVKPYSCHFCGRGFAY 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-540 2.90e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 363 FSTLTQLKRHLASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLKQHSLTHKGV 435
Cdd:COG5048  270 SQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 436 KEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FKCKVCGKSFN 504
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 133777064 505 RMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 540
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 6.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.34e-04
                          10        20
                  ....*....|....*....|....*
gi 133777064  481 LKTHMIVHSPVKPFKCKVCGKSFNR 505
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 133777064  284 HLQTHLLTHQGTRPHKCQVCHKAFTQ 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*.
gi 133777064  312 HLKRHMLLHSEVKPYSCHFCGRGFAY 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-540 2.90e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 363 FSTLTQLKRHLASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLKQHSLTHKGV 435
Cdd:COG5048  270 SQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 436 KEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FKCKVCGKSFN 504
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 133777064 505 RMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 540
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-542 1.08e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 372 HLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVR-PFVCTECGMEFSQIHHLKQH----SLTHKGVKEFKC--EVCG 444
Cdd:COG5048  251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHlrsvNHSGESLKPFSCpySLCG 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 445 REFTLQANMKRHMLIHTSVRPYQCHICFKTF-------------VQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLlg 511
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKEKLLNSSSkfspllnneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHI-- 408

                        170       180       190
                 ....*....|....*....|....*....|.
gi 133777064 512 HMHLHAGSKPFKCPYCSSKFNLKGNLSRHMK 542
Cdd:COG5048  409 ITHLSFRPYNCKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-484 3.51e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 250 SYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEV------ 323
Cdd:COG5048  207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgf 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 324 -KPYSCHFCGRGFAYPSELKAH--EVKH--ESGRCHVCVE--CGLDFSTLTQLKRHLASHQGPTLYQCLECD-------K 389
Cdd:COG5048  287 sLPIKSKQCNISFSRSSPLTRHlrSVNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspL 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 390 SFHYRSQLQNHMLKHQNVRPFVCT--ECGMEFSQIHHLKQHSLTHKGVK--EFKCEVCGREFTLQANMKRHMLIHTSVRP 465
Cdd:COG5048  367 LNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        250
                 ....*....|....*....
gi 133777064 466 YQCHICFKtFVQKQTLKTH 484
Cdd:COG5048  447 LLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-536 5.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 5.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 247 CEKSYTSKYNLVTHILGHNGIKPHSCPH--CSKLFKQPSHLQTHLLTHQGTRPHKC-QVCHKAFTQTSHLKRHMLLHSEV 323
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 324 KPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLD-------FSTLTQLKRHLASHQGPTLYQCLEC-DKSFHYRS 395
Cdd:COG5048  119 DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKDPSSNLSLLISsNVSTSIPS 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 396 QLQNHMLKHQNVRPFVCTECGMEFSQIH--------HLKQHSLTHKGVKEFK------CEVCGREFTLQANMKRHMLIHT 461
Cdd:COG5048  199 SSENSPLSSSYSIPSSSSDQNLENSSSSlplttnsqLSPKSLLSQSPSSLSSsdssssASESPRSSLPTASSQSSSPNES 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 462 SVR-------PYQCHICFKTFVQKQTLKTHM--IVHS--PVKPFKCKV--CGKSFNRMYNLLGHMHLHAGSKPFKCPY-- 526
Cdd:COG5048  279 DSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLln 358

                        330
                 ....*....|
gi 133777064 527 CSSKFNLKGN 536
Cdd:COG5048  359 SSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-611 1.39e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 268 KPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQV--CHKAFTQTSHLKRHMLLHSEVKPY-SCHFCGRGFAYPSELKAH 344
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 345 EVKHESGRCHVCVECGLDFSTLTQLKRHLASH---QGPTLYQCL----ECDKSFHYRSQLQNHMLKHQNVRPFV------ 411
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNsssvNTPQSNSLHPPLPANSLSKDPSSNLSllissn 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 412 ---------CTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLK 482
Cdd:COG5048  192 vstsipsssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777064 483 THMIVHSPV-------KPFKCKVCGKSFNRMYNLLGHM----HLHAGSKPFKCPY--CSSKFNLKGNLSRHMKVKHGVMD 549
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsvnHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 133777064 550 ISLDSQDPMMELAGPDPSEL-DNHQEMEDFEENAYTYSSVDSSaEASTLTEQAMKEMAYYNVL 611
Cdd:COG5048  352 AKEKLLNSSSKFSPLLNNEPpQSLQQYKDLKNDKKSETLSNSC-IRNFKRDSNLSLHIITHLS 413
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 6.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.34e-04
                          10        20
                  ....*....|....*....|....*
gi 133777064  481 LKTHMIVHSPVKPFKCKVCGKSFNR 505
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 133777064  284 HLQTHLLTHQGTRPHKCQVCHKAFTQ 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 298-320 3.19e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.19e-03
                          10        20
                  ....*....|....*....|...
gi 133777064  298 HKCQVCHKAFTQTSHLKRHMLLH 320
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*.
gi 133777064  312 HLKRHMLLHSEVKPYSCHFCGRGFAY 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 294-348 6.58e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.58e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133777064 294 GTRPHKCQV--CHKAFTQTSHLKRHML-------------------LHSEVKPYSCHFCGRGFAYPSELKAHeVKH 348
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH-RKH 420
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 382-404 8.69e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.69e-03
                          10        20
                  ....*....|....*....|...
gi 133777064  382 YQCLECDKSFHYRSQLQNHMLKH 404
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 466-488 9.40e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.40e-03
                          10        20
                  ....*....|....*....|...
gi 133777064  466 YQCHICFKTFVQKQTLKTHMIVH 488
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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