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Conserved domains on  [gi|31565630|gb|AAH53702|]
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Thrombospondin 2 [Mus musculus]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10641979)

thrombospondin type-1 domain-containing protein similar to Plasmodium circumsporozoite protein that is an essential sporozoite protein required for development of malaria sporozoites in mosquitoes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 974-1171 1.41e-119

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 367.35  E-value: 1.41e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630    974 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDK 1053
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630   1054 PSRAYGYSGVSLKVVNSTTGTGEHLRNALWRTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGYMRVLVHEGKQV 1133
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 31565630   1134 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1171
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 21-213 3.38e-43

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


:

Pssm-ID: 214560  Cd Length: 184  Bit Score: 155.59  E-value: 3.38e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630      21 HVKDTS-FDLFSISNINRKTIGAKqfrgpdPGVPAYRFVrfdyiPPVNTDDLNRIVKLARRKEGFFLTAQLKQDRKSRGT 99
Cdd:smart00210    1 GQDLLQvFDLPSLSFAIRQVVGPE------PGSPAYRLG-----DPALVPQPTRDLFPSGLPEDFSLLTTFRQTPKSRGV 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630     100 LLVLEGPGTSqRQFEIVSNGPGDTLDLNY-RVEGNQHTNFLEDVGLADSQWKNVTVQVASDTYSLYVGCDLIDSVTLEEP 178
Cdd:smart00210   70 LFAIYDAQNV-RQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                           170       180       190
                    ....*....|....*....|....*....|....*
gi 31565630     179 FYEQLEVDRSRMYVAKGASREsHFRGLLQNVHLVF 213
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVC 182
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 497-549 1.40e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 77.63  E-value: 1.40e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 31565630     497 WSPWSPWSACTVTCAGGIRERSRVCNSPEPQYGGKDCVGDVTEHQMCNKRSCP 549
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 320-374 4.88e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 75.92  E-value: 4.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 31565630    320 CVQEGRIFAENETWVVDSCTTCTCKKFKTVCHQITCSPATCANP--SFVEGECCPSC 374
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 440-492 6.28e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.70  E-value: 6.28e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 31565630     440 WSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKPCQRDPCP 492
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
385-430 9.28e-13

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 9.28e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 31565630    385 SPWAEWTECSVTCGSGTQQRGRSCDVT---SNTCLGPSIQTRTCSLGKC 430
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 848-884 2.05e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.83  E-value: 2.05e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 31565630    848 DQDNDLVGDQCDNneDIDDDGHQNNQDNCPYISNSNQ 884
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 921-951 3.09e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.44  E-value: 3.09e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 31565630    921 EDSDGDGRGDICKDDFDNDNVPDIDDVCPEN 951
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 789-823 1.56e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.51  E-value: 1.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 31565630    789 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 823
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 652-691 4.89e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 4.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31565630    652 CKDKTHSCHKNAECIYlghfSDPMYKCECQIGYAGDGLIC 691
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 974-1171 1.41e-119

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 367.35  E-value: 1.41e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630    974 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDK 1053
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630   1054 PSRAYGYSGVSLKVVNSTTGTGEHLRNALWRTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGYMRVLVHEGKQV 1133
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 31565630   1134 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1171
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 21-213 3.38e-43

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 155.59  E-value: 3.38e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630      21 HVKDTS-FDLFSISNINRKTIGAKqfrgpdPGVPAYRFVrfdyiPPVNTDDLNRIVKLARRKEGFFLTAQLKQDRKSRGT 99
Cdd:smart00210    1 GQDLLQvFDLPSLSFAIRQVVGPE------PGSPAYRLG-----DPALVPQPTRDLFPSGLPEDFSLLTTFRQTPKSRGV 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630     100 LLVLEGPGTSqRQFEIVSNGPGDTLDLNY-RVEGNQHTNFLEDVGLADSQWKNVTVQVASDTYSLYVGCDLIDSVTLEEP 178
Cdd:smart00210   70 LFAIYDAQNV-RQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                           170       180       190
                    ....*....|....*....|....*....|....*
gi 31565630     179 FYEQLEVDRSRMYVAKGASREsHFRGLLQNVHLVF 213
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVC 182
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 497-549 1.40e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 77.63  E-value: 1.40e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 31565630     497 WSPWSPWSACTVTCAGGIRERSRVCNSPEPQYGGKDCVGDVTEHQMCNKRSCP 549
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 320-374 4.88e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 75.92  E-value: 4.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 31565630    320 CVQEGRIFAENETWVVDSCTTCTCKKFKTVCHQITCSPATCANP--SFVEGECCPSC 374
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 440-492 6.28e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.70  E-value: 6.28e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 31565630     440 WSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKPCQRDPCP 492
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
498-548 9.43e-16

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 72.07  E-value: 9.43e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31565630    498 SPWSPWSACTVTCAGGIRERSRVCNSPEPqyGGKDCVGDVTEHQMCNKRSC 548
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
441-491 8.15e-15

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 69.37  E-value: 8.15e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31565630    441 SHWSPWSSCSVTCGVGNVTRIRLCNSPVPqmGGKNCKGSGRETKPCQRDPC 491
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
320-374 5.75e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 67.54  E-value: 5.75e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 31565630     320 CVQEGRIFAENETWVVDSCTTCTCKKFKTV-CHQITCSPAT-CANPS--FVEGECCPSC 374
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
385-430 9.28e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 9.28e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 31565630    385 SPWAEWTECSVTCGSGTQQRGRSCDVT---SNTCLGPSIQTRTCSLGKC 430
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 384-431 5.24e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 61.83  E-value: 5.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 31565630     384 WSPWAEWTECSVTCGSGTQQRGRSCDVTSNT-----CLGPSIQTRTCSLGKCD 431
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 848-884 2.05e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.83  E-value: 2.05e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 31565630    848 DQDNDLVGDQCDNneDIDDDGHQNNQDNCPYISNSNQ 884
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 921-951 3.09e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.44  E-value: 3.09e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 31565630    921 EDSDGDGRGDICKDDFDNDNVPDIDDVCPEN 951
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 789-823 1.56e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.51  E-value: 1.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 31565630    789 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 823
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 652-691 4.89e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 4.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31565630    652 CKDKTHSCHKNAECIYlghfSDPMYKCECQIGYAGDGLIC 691
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 386-406 1.55e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|.
gi 31565630   386 PWAEWTECSVTCGSGTQQRGR 406
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSR 262
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 499-519 6.78e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 40.33  E-value: 6.78e-03
                          10        20
                  ....*....|....*....|.
gi 31565630   499 PWSPWSACTVTCAGGIRERSR 519
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSR 262
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 974-1171 1.41e-119

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 367.35  E-value: 1.41e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630    974 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDK 1053
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630   1054 PSRAYGYSGVSLKVVNSTTGTGEHLRNALWRTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGYMRVLVHEGKQV 1133
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 31565630   1134 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1171
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 21-213 3.38e-43

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 155.59  E-value: 3.38e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630      21 HVKDTS-FDLFSISNINRKTIGAKqfrgpdPGVPAYRFVrfdyiPPVNTDDLNRIVKLARRKEGFFLTAQLKQDRKSRGT 99
Cdd:smart00210    1 GQDLLQvFDLPSLSFAIRQVVGPE------PGSPAYRLG-----DPALVPQPTRDLFPSGLPEDFSLLTTFRQTPKSRGV 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31565630     100 LLVLEGPGTSqRQFEIVSNGPGDTLDLNY-RVEGNQHTNFLEDVGLADSQWKNVTVQVASDTYSLYVGCDLIDSVTLEEP 178
Cdd:smart00210   70 LFAIYDAQNV-RQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                           170       180       190
                    ....*....|....*....|....*....|....*
gi 31565630     179 FYEQLEVDRSRMYVAKGASREsHFRGLLQNVHLVF 213
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVC 182
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 497-549 1.40e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 77.63  E-value: 1.40e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 31565630     497 WSPWSPWSACTVTCAGGIRERSRVCNSPEPQYGGKDCVGDVTEHQMCNKRSCP 549
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 320-374 4.88e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 75.92  E-value: 4.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 31565630    320 CVQEGRIFAENETWVVDSCTTCTCKKFKTVCHQITCSPATCANP--SFVEGECCPSC 374
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 440-492 6.28e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.70  E-value: 6.28e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 31565630     440 WSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKPCQRDPCP 492
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
498-548 9.43e-16

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 72.07  E-value: 9.43e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31565630    498 SPWSPWSACTVTCAGGIRERSRVCNSPEPqyGGKDCVGDVTEHQMCNKRSC 548
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
441-491 8.15e-15

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 69.37  E-value: 8.15e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31565630    441 SHWSPWSSCSVTCGVGNVTRIRLCNSPVPqmGGKNCKGSGRETKPCQRDPC 491
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
320-374 5.75e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 67.54  E-value: 5.75e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 31565630     320 CVQEGRIFAENETWVVDSCTTCTCKKFKTV-CHQITCSPAT-CANPS--FVEGECCPSC 374
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
385-430 9.28e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 9.28e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 31565630    385 SPWAEWTECSVTCGSGTQQRGRSCDVT---SNTCLGPSIQTRTCSLGKC 430
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 384-431 5.24e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 61.83  E-value: 5.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 31565630     384 WSPWAEWTECSVTCGSGTQQRGRSCDVTSNT-----CLGPSIQTRTCSLGKCD 431
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 498-548 4.11e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 56.13  E-value: 4.11e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31565630    498 SPWSPWSACTVTCAGGIRERSRVCNSPePQYGGKDCvGDVTEHQMCNKRSC 548
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 441-491 1.62e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 54.59  E-value: 1.62e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31565630    441 SHWSPWSSCSVTCGVGNVTRIRLCNSPvPQMGGKNCkGSGRETKPCQRDPC 491
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 848-884 2.05e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.83  E-value: 2.05e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 31565630    848 DQDNDLVGDQCDNneDIDDDGHQNNQDNCPYISNSNQ 884
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 921-951 3.09e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.44  E-value: 3.09e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 31565630    921 EDSDGDGRGDICKDDFDNDNVPDIDDVCPEN 951
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 789-823 1.56e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.51  E-value: 1.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 31565630    789 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 823
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 385-430 3.30e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.04  E-value: 3.30e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 31565630    385 SPWAEWTECSVTCGSGTQQR-----------GRSCdvtsntclGPSIQTRTCSLGKC 430
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRtrtvivepqngGRPC--------PELLERRPCNLPPC 52
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 652-691 4.89e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 4.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31565630    652 CKDKTHSCHKNAECIYlghfSDPMYKCECQIGYAGDGLIC 691
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 445-491 1.84e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 1.84e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31565630    445 PWSSCSVTCGVGNVTRIRLCNSPVPQ--MGGKNCKGSGR--ETKPCQRDPC 491
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 386-406 1.55e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|.
gi 31565630   386 PWAEWTECSVTCGSGTQQRGR 406
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSR 262
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 502-548 2.11e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.43  E-value: 2.11e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31565630    502 PWSACTVTCAGGIRERSRVCNSPEPQ--YGGKDCVGDV--TEHQMCNKRSC 548
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKkpPETQSCNLKPC 55
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 444-491 3.40e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 36.54  E-value: 3.40e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 31565630    444 SPWSSCSVTCGVGNVTRIRLCNspvpqmggKNCKgSGRETKPCQRDPC 491
Cdd:pfam19035    6 TEWSPCSKTCGMGVSTRVSNDN--------AECK-LVTETRLCQLRPC 44
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 390-430 4.41e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 4.41e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 31565630    390 WTECSVTCGSGTQQR--------------GRSCDVTSNtclgPSIqTRTCSLGKC 430
Cdd:pfam19030    6 WGECSVTCGGGVQTRlvqcvqkgggsivpDSECSAQKK----PPE-TQSCNLKPC 55
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 499-519 6.78e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 40.33  E-value: 6.78e-03
                          10        20
                  ....*....|....*....|.
gi 31565630   499 PWSPWSACTVTCAGGIRERSR 519
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSR 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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