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Conserved domains on  [gi|29437323|gb|AAH49723|]
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Ly6k protein [Mus musculus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 21-112 1.57e-40

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467080  Cd Length: 86  Bit Score: 130.90  E-value: 1.57e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  21 LTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVsppstnPPSEPKEFLIEKPMPFLFYK 100
Cdd:cd23550   1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEV------PPPPPKSFVLEKPMPFLYIK 74

                        90
                ....*....|..
gi 29437323 101 CCQWDSCNGEGP 112
Cdd:cd23550  75 CCRENLCNEEGP 86
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 21-112 1.57e-40

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 130.90  E-value: 1.57e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  21 LTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVsppstnPPSEPKEFLIEKPMPFLFYK 100
Cdd:cd23550   1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEV------PPPPPKSFVLEKPMPFLYIK 74

                        90
                ....*....|..
gi 29437323 101 CCQWDSCNGEGP 112
Cdd:cd23550  75 CCRENLCNEEGP 86
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-113 4.28e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 37.13  E-value: 4.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323     21 LTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFF--YVSKQCTRR--CPTPVVsppstnppsepkeFLIEKPMPF 96
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISDSRgsVVYKGCATSpiCPGSHG-------------YEINLTIAF 67

                           90
                   ....*....|....*..
gi 29437323     97 LFYKCCQWDSCNGEGPP 113
Cdd:smart00134  68 LKVSCCQTDLCNAAGPG 84
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-67 1.01e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 35.98  E-value: 1.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 29437323    23 CHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFF---YVSKQCTR 67
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLrgtVVSKGCAR 48
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 21-112 1.57e-40

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 130.90  E-value: 1.57e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  21 LTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVsppstnPPSEPKEFLIEKPMPFLFYK 100
Cdd:cd23550   1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEV------PPPPPKSFVLEKPMPFLYIK 74

                        90
                ....*....|..
gi 29437323 101 CCQWDSCNGEGP 112
Cdd:cd23550  75 CCRENLCNEEGP 86
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 21-112 2.71e-09

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 51.22  E-value: 2.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  21 LTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPstnPPSEPKefLIEKPMPFLFYK 100
Cdd:cd23555   1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQ---PPEAPR--KIPKTNSFYFVM 75

                        90
                ....*....|..
gi 29437323 101 CCQWDSCNGEGP 112
Cdd:cd23555  76 CCSSMFCNEGGP 87
TFP_LU_ECD_LYNX1 cd23585
extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; ...
 20-109 1.10e-05

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467115  Cd Length: 74  Bit Score: 41.14  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  20 ALTCHVCeAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEpkefliekpmpflfy 99
Cdd:cd23585   1 ALDCHVC-AYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTT--------------- 64

                        90
                ....*....|
gi 29437323 100 KCCQWDSCNG 109
Cdd:cd23585  65 SCCQYDLCNG 74
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 19-108 2.92e-04

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 37.33  E-value: 2.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  19 NALTCHVCEAQNS-YACSNPSQCPGEKKFCL--LAVTRIFERF-FYVSKQCTRRCPTPVVSPPSTNppsepkefliekpm 94
Cdd:cd23543   1 HSLYCYTCENQSSnWNCLKPTKCSDNDKYCVttVASGGTGSSSgVRITKKCSPKCPETNVNIGIAS-------------- 66

                        90
                ....*....|....
gi 29437323  95 pfLFYKCCQWDSCN 108
Cdd:cd23543  67 --VSTSCCQSSLCN 78
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-113 4.28e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 37.13  E-value: 4.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323     21 LTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFF--YVSKQCTRR--CPTPVVsppstnppsepkeFLIEKPMPF 96
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISDSRgsVVYKGCATSpiCPGSHG-------------YEINLTIAF 67

                           90
                   ....*....|....*..
gi 29437323     97 LFYKCCQWDSCNGEGPP 113
Cdd:smart00134  68 LKVSCCQTDLCNAAGPG 84
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-67 1.01e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 35.98  E-value: 1.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 29437323    23 CHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFF---YVSKQCTR 67
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLrgtVVSKGCAR 48
TFP_snake_toxin cd00206
Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, ...
 21-108 3.81e-03

Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheets; it exists as either a monomer or a dimer. The snake toxin domain exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold), which also includes extracellular domain (ECD) found in Ly-6 antigen/uPA receptor-like (LU) superfamily.


Pssm-ID: 467061  Cd Length: 64  Bit Score: 34.24  E-value: 3.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  21 LTCHVCeaqNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPtpvvsppstnppsepkeflieKPMPFLFYK 100
Cdd:cd00206   1 LICYNC---PSSTCPTTKTCPPGENLCYKKWWRDGPRGKRIERGCAATCP---------------------KPKPGEKVK 56


                ....*...
gi 29437323 101 CCQWDSCN 108
Cdd:cd00206  57 CCSTDKCN 64
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 21-108 4.50e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 34.38  E-value: 4.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  21 LTCHVCEAQNSYACSNPS----QCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEpkefliekpmpF 96
Cdd:cd00117   1 LKCYQCNSSNDPNCCNSSptlvTCSSPETFCRKIVGKVGGGETLVIRGCATECECGCTECCSGTGTSG-----------T 69

                        90
                ....*....|..
gi 29437323  97 LFYKCCQWDSCN 108
Cdd:cd00117  70 TCTSCCDTDLCN 81
TFP_LU_ECD_PINLYP_rpt1 cd23571
first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 20-109 5.02e-03

first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467101  Cd Length: 89  Bit Score: 34.31  E-value: 5.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  20 ALTCHVCEAQNSyACSNPSQ-CPGEKKFCLLAV---TRIFERFFYVSKQCTRR--CPTPVVSppSTNPPSEPKEFLIekp 93
Cdd:cd23571   3 PLSCEVCKSKGS-LCSGPLQtCAPGEDACLTLTgetTLGGNGLVRTFKGCLKPsdCPSGPFS--FTFFPKIRMRRNS--- 76

                        90
                ....*....|....*.
gi 29437323  94 mpflfyKCCQWDSCNG 109
Cdd:cd23571  77 ------KCCQTDGCNS 86
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 17-109 6.51e-03

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 33.93  E-value: 6.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29437323  17 QSNALTCHVCEaqNSYACSNPSQCPGEKKFCLLAvTRIFERFFYVSKQCTRRCPTPVVSPPSTnppsepkefliekpMPF 96
Cdd:cd23542   2 PANALQCHVCN--SSSNCTNPVNCEGSERYCKTT-TVVQPSGNLVKKGCAETCPPSTSRQQVG--------------SGI 64

                        90
                ....*....|...
gi 29437323  97 LFYKCCQWDSCNG 109
Cdd:cd23542  65 SSVTCCQGDLCNS 77
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 20-71 9.96e-03

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 33.46  E-value: 9.96e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 29437323  20 ALTCHVCEAQNSYA-CSNPSQCPGEKKFCLLAVTR---IFERFFYVSKQCTRRCPT 71
Cdd:cd23575   2 SLKCYTCVSAHSNSdCLTETNCSSSDTYCKTLVASasgGSGSLTTITKWCASSCTP 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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