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Conserved domains on  [gi|21411400|gb|AAH31103|]
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CD200 molecule [Homo sapiens]

Protein Classification

IgV_1_MRC-OX-2_like and Ig domain-containing protein( domain architecture ID 10146997)

IgV_1_MRC-OX-2_like and Ig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 32-139 3.85e-56

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


:

Pssm-ID: 409433  Cd Length: 108  Bit Score: 175.61  E-value: 3.85e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  32 VQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNI 111
Cdd:cd05846   1 VVVHTGDTRAVLGGNATLSCNLTLPEEVLQVTWQKIKASSPENIVTYSKKYGVKIQPSYVRRISFTSSGLNSTSITIWNV 80

                        90       100
                ....*....|....*....|....*...
gi 21411400 112 TLEDEGCYMCLFNTFGFGKISGTACLTV 139
Cdd:cd05846  81 TLEDEGCYKCLFNTFPDGIKSGTACLTV 108
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 159-230 8.93e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05719:

Pssm-ID: 472250  Cd Length: 96  Bit Score: 43.25  E-value: 8.93e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21411400 159 TC-SATARPAPMVFWKVPRSGIENSTvTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVN 230
Cdd:cd05719  22 TCiSANGKPPASVTWETDLKGEASTT-QVRGSNGTVTVTSRYRLVPSREADGQPLTCVVEHPSLEKDQRISVT 93
 
Name Accession Description Interval E-value
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 32-139 3.85e-56

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 175.61  E-value: 3.85e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  32 VQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNI 111
Cdd:cd05846   1 VVVHTGDTRAVLGGNATLSCNLTLPEEVLQVTWQKIKASSPENIVTYSKKYGVKIQPSYVRRISFTSSGLNSTSITIWNV 80

                        90       100
                ....*....|....*....|....*...
gi 21411400 112 TLEDEGCYMCLFNTFGFGKISGTACLTV 139
Cdd:cd05846  81 TLEDEGCYKCLFNTFPDGIKSGTACLTV 108
IGv smart00406
Immunoglobulin V-Type;
47-123 2.56e-09

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 52.77  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400     47 ASLKCSL-QNAQEALIVTWQKKK-AVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNS-TITFWNITLEDEGCYMCLF 123
Cdd:smart00406   2 VTLSCKFsGSTFSSYYVSWVRQPpGKGLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDvSLTISNLRVEDTGTYYCAV 81
PHA02987 PHA02987
Ig domain OX-2-like protein; Provisional
 43-139 3.59e-07

Ig domain OX-2-like protein; Provisional


Pssm-ID: 165290 [Multi-domain]  Cd Length: 189  Bit Score: 49.48  E-value: 3.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400   43 LYTPASLKCSLQNAQEALIVTWQKKKavspENMVTFSEnHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCL 122
Cdd:PHA02987  29 EHVNVKISCNKTSSFNSILITWKKNN----KTIAGYGP-CGPVIVDKFKNKIEYLSKSFNESTILIKNVSLKDNGCYTCI 103

                         90
                 ....*....|....*....
gi 21411400  123 FNTFgFGKIS--GTACLTV 139
Cdd:PHA02987 104 FNTL-LSKNNekGVVCLNV 121
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 47-136 1.72e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 45.26  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400    47 ASLKCSLQNAQEALIVTWQKKKAVSPENMvtfsenhgvviqpaykdKINITQLGLQNSTITFWNITLEDEGCYMCLFNTF 126
Cdd:pfam00047  14 ATLTCSASTGSPGPDVTWSKEGGTLIESL-----------------KVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNP 76

                          90
                  ....*....|
gi 21411400   127 GFGKISGTAC 136
Cdd:pfam00047  77 GGSATLSTSL 86
IgC1_2_PVR_like cd05719
Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and Necl-5), ...
 159-230 8.93e-06

Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and Necl-5), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (Necl-5)) and similar proteins. Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), these result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted, while CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" and has a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the second Ig-like domain of nectin-1, also known as poliovirus receptor related protein(PVRL)1 or CD111.


Pssm-ID: 409384  Cd Length: 96  Bit Score: 43.25  E-value: 8.93e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21411400 159 TC-SATARPAPMVFWKVPRSGIENSTvTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVN 230
Cdd:cd05719  22 TCiSANGKPPASVTWETDLKGEASTT-QVRGSNGTVTVTSRYRLVPSREADGQPLTCVVEHPSLEKDQRISVT 93
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 143-220 1.24e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 42.57  E-value: 1.24e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21411400   143 PIVSLHYKFSEDHLNITCSA-TARPAPMVFWKVPRSGIENSTVTlSHPNGTTSVTSILHIKDPKNQVGkEVICQVLHLG 220
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSAsTGSPGPDVTWSKEGGTLIESLKV-KHDNGRTTQSSLLISNVTKEDAG-TYTCVVNNPG 77
 
Name Accession Description Interval E-value
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 32-139 3.85e-56

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 175.61  E-value: 3.85e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  32 VQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNI 111
Cdd:cd05846   1 VVVHTGDTRAVLGGNATLSCNLTLPEEVLQVTWQKIKASSPENIVTYSKKYGVKIQPSYVRRISFTSSGLNSTSITIWNV 80

                        90       100
                ....*....|....*....|....*...
gi 21411400 112 TLEDEGCYMCLFNTFGFGKISGTACLTV 139
Cdd:cd05846  81 TLEDEGCYKCLFNTFPDGIKSGTACLTV 108
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 31-139 1.09e-17

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 76.72  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  31 QVQVVTQdEREQLYTPASLKCSLQNAQEALI--VTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINIT--QLGLQNSTI 106
Cdd:cd05718   2 RVQVPTE-VTGFLGGSVTLPCSLTSPGTTKItqVTWMKIGAGSSQNVAVFHPQYGPSVPNPYAERVEFLaaRLGLRNATL 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 21411400 107 TFWNITLEDEGCYMCLFNTFGFGKISGTACLTV 139
Cdd:cd05718  81 RIRNLRVEDEGNYICEFATFPQGNRQGTTWLRV 113
IgV_1_Nectin-1_like cd05886
First immunoglobulin variable (IgV) domain of nectin-1, and similar domains; The members here ...
 33-140 2.28e-13

First immunoglobulin variable (IgV) domain of nectin-1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1 (PVRL1) or cluster of differentiation (CD) 111). Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. In addition nectins heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls), nectin-1 for example, has been shown to trans-interact with Necl-1. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1). Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D.


Pssm-ID: 409469  Cd Length: 113  Bit Score: 64.99  E-value: 2.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  33 QVVTQDEREQLY--TPASLKCSLQNAQEALI---VTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTIT 107
Cdd:cd05886   1 QTVQVNDSMSGFigTDVVLHCSFANPLPSVKitqVTWQKSTNGSKQNVAIYNPSMGVSVLPPYRERVTFLNPSFTDGTIR 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 21411400 108 FWNITLEDEGCYMCLFNTFGFGKISGTACLTVY 140
Cdd:cd05886  81 LSRLELEDEGVYICEFATFPTGNRESQLNLTVM 113
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 32-139 6.78e-10

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 55.28  E-value: 6.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  32 VQVVTQdEREQLYTPASLKCSLQ---NAQEALIVTWQKKKavSPENMVTFSENHGVVIQPAYKDKINITQLG--LQNSTI 106
Cdd:cd20989   3 VQVPPE-VRGFLGGSVTLPCHLLppnMVTHVSQVTWQRHD--EHGSVAVFHPKQGPSFPESERLSFVAARLGaeLRNASL 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 21411400 107 TFWNITLEDEGCYMCLFNTFGFGKISGTACLTV 139
Cdd:cd20989  80 AMFGLRVEDEGNYTCEFATFPQGSRSGDTWLRV 112
IGv smart00406
Immunoglobulin V-Type;
47-123 2.56e-09

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 52.77  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400     47 ASLKCSL-QNAQEALIVTWQKKK-AVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNS-TITFWNITLEDEGCYMCLF 123
Cdd:smart00406   2 VTLSCKFsGSTFSSYYVSWVRQPpGKGLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDvSLTISNLRVEDTGTYYCAV 81
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
 48-139 7.31e-08

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 49.55  E-value: 7.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  48 SLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFG 127
Cdd:cd05887  18 SLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGISIQGEYQGRVSFKNYSLNDATITLHNVGFSDSGKYICKAVTFP 97

                        90
                ....*....|..
gi 21411400 128 FGKISGTACLTV 139
Cdd:cd05887  98 LGNAQSSTTVTV 109
PHA02987 PHA02987
Ig domain OX-2-like protein; Provisional
 43-139 3.59e-07

Ig domain OX-2-like protein; Provisional


Pssm-ID: 165290 [Multi-domain]  Cd Length: 189  Bit Score: 49.48  E-value: 3.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400   43 LYTPASLKCSLQNAQEALIVTWQKKKavspENMVTFSEnHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCL 122
Cdd:PHA02987  29 EHVNVKISCNKTSSFNSILITWKKNN----KTIAGYGP-CGPVIVDKFKNKIEYLSKSFNESTILIKNVSLKDNGCYTCI 103

                         90
                 ....*....|....*....
gi 21411400  123 FNTFgFGKIS--GTACLTV 139
Cdd:PHA02987 104 FNTL-LSKNNekGVVCLNV 121
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 47-136 1.72e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 45.26  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400    47 ASLKCSLQNAQEALIVTWQKKKAVSPENMvtfsenhgvviqpaykdKINITQLGLQNSTITFWNITLEDEGCYMCLFNTF 126
Cdd:pfam00047  14 ATLTCSASTGSPGPDVTWSKEGGTLIESL-----------------KVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNP 76

                          90
                  ....*....|
gi 21411400   127 GFGKISGTAC 136
Cdd:pfam00047  77 GGSATLSTSL 86
IgC1_2_PVR_like cd05719
Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and Necl-5), ...
 159-230 8.93e-06

Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and Necl-5), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (Necl-5)) and similar proteins. Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), these result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted, while CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" and has a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the second Ig-like domain of nectin-1, also known as poliovirus receptor related protein(PVRL)1 or CD111.


Pssm-ID: 409384  Cd Length: 96  Bit Score: 43.25  E-value: 8.93e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21411400 159 TC-SATARPAPMVFWKVPRSGIENSTvTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVN 230
Cdd:cd05719  22 TCiSANGKPPASVTWETDLKGEASTT-QVRGSNGTVTVTSRYRLVPSREADGQPLTCVVEHPSLEKDQRISVT 93
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 143-220 1.24e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 42.57  E-value: 1.24e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21411400   143 PIVSLHYKFSEDHLNITCSA-TARPAPMVFWKVPRSGIENSTVTlSHPNGTTSVTSILHIKDPKNQVGkEVICQVLHLG 220
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSAsTGSPGPDVTWSKEGGTLIESLKV-KHDNGRTTQSSLLISNVTKEDAG-TYTCVVNNPG 77
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
 48-126 1.49e-05

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


Pssm-ID: 409472  Cd Length: 111  Bit Score: 43.31  E-value: 1.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  48 SLKCSLQNAQEALIVTWQKKKAVSpENMVTFSENHGVVIQPAYKDKINI--TQLGLQNSTITFWNITLEDEGCYMCLFNT 125
Cdd:cd05889  18 SLECVYPSTGILTQVEWTKIGGQK-DNIAVYHPTHGMHIRKPYAGRVYFlnSTMASNNMSLSFRNASEDDVGYYSCSLYT 96


                .
gi 21411400 126 F 126
Cdd:cd05889  97 Y 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 71-139 3.83e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 3.83e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21411400     71 SPENMVTFSENHGVVIqpAYKDKINITQLGlQNSTITFWNITLEDEGCYMCLFnTFGFGKISGTACLTV 139
Cdd:smart00410  21 SPPPEVTWYKQGGKLL--AESGRFSVSRSG-STSTLTISNVTPEDSGTYTCAA-TNSSGSASSGTTLTV 85
IgC1_2_Nectin-2_Necl-5_like cd07703
Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; ...
 159-218 4.74e-04

Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; member of the C1-set of the Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409500  Cd Length: 97  Bit Score: 38.54  E-value: 4.74e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21411400 159 TC-SATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKdPKNQV-GKEVICQVLH 218
Cdd:cd07703  21 RCvSANGRPPARISWSSTLNGNANTTQVPGPDSGTVTVTSEYSLV-PTPEAnGKEVTCKVEH 81
IgC1_2_Nectin-3-4_like cd07704
Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related ...
 159-228 4.79e-04

Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 or cluster of differentiation (CD) 113) and nectin-4 (poliovirus receptor related protein 4). Nectin-3 and nectin-4 belong to the nectin family comprised of four transmembrane glycoproteins (nectin-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. Nectin-3 has also been shown to form a heterophilic trans-interaction with nectin-1 in ciliary epithelia, establishing the apex-apex adhesion between the pigment and non-pigment cell layers. Nectin-4 has recently been identified in several types of breast carcinoma and can be used as a histological and serological marker for breast cancer.


Pssm-ID: 409501  Cd Length: 96  Bit Score: 38.65  E-value: 4.79e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21411400 159 TCSA-TARPAPMVFWKVPRSGIEnSTVTLSHPNgTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQT 228
Cdd:cd07704  23 SCTAeTGKPAASVTWETDLGGME-SSRTFEHNR-TATVTSEYHLVPTRFANGRPLTCVVSHPALQQDIRIT 91
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 35-121 1.68e-03

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 37.13  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  35 VTQDERE---QLYTPASLKCSLQNAQEALIVTWQK-KKAVSpenMVTFSENHgvvIQPAYKDKINITqlglqNSTITFWN 110
Cdd:cd20946   2 VPSSQQVvtvVENQEVILSCKTPKKTSSPRVEWKKlQRDVT---FVVFQNNK---IQGDYKGRAEIL-----GTNITIKN 70

                        90
                ....*....|.
gi 21411400 111 ITLEDEGCYMC 121
Cdd:cd20946  71 VTRSDSGKYRC 81
PHA03376 PHA03376
BARF1; Provisional
 56-204 1.99e-03

BARF1; Provisional


Pssm-ID: 177613  Cd Length: 221  Bit Score: 38.54  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400   56 AQEALIVTWQKKKAVSPENMVTFSE----NHGVVIQPAYKDKINITQ-----LGLQNSTITFWNI----TLEDEGCYMCL 122
Cdd:PHA03376  26 GERVTLTSYWRRVSLGPEIEVSWFKlgpgEEQVLIGRMHHDVIFIEWpfrgfFDIHRSANTFFLVvtaaNISHDGNYLCR 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  123 FNtFGFGKISGTACLTVyVQPI-VSLHYKFSE----DHLNITCSATARPAPMVFWKVPRSGIENSTVT----LSHPNGTT 193
Cdd:PHA03376 106 MK-LGETEVTKQEHLSV-VKPLtLSVHSERSQfpdfSVLTVTCTVNAFPHPHVQWLMPEGVEPAPTAAnggvMKEKDGSL 183

                        170
                 ....*....|.
gi 21411400  194 SVTSILHIKDP 204
Cdd:PHA03376 184 SVAVDLSLPKP 194
PHA02982 PHA02982
hypothetical protein; Provisional
 31-174 6.04e-03

hypothetical protein; Provisional


Pssm-ID: 165285 [Multi-domain]  Cd Length: 251  Bit Score: 37.38  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400   31 QVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKK--AVSPENMVTFSENHGVVIQPAYKDKINITQLGlQNSTITF 108
Cdd:PHA02982  26 DLKEDTADVNATVDQEVKLQCLFKDADEISRAMWKGDAgfMLAQEANGGTGINAFNYVPGPYKDKYALSVSG-NSSTFTM 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21411400  109 WNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLhykfSEDHLN---ITCSATARPAPMVFWKV 174
Cdd:PHA02982 105 KKPDPQNLGCFTCEAKDAEGKEETCEKCLEIQKEDILYV----VEEHNNetiITCFVGSKHGDVPRFIV 169
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 156-216 6.95e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 34.61  E-value: 6.95e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21411400 156 LNITCSATARPAPMVFWKVPRSGIENSTVtlsHPNGTTSVTSILHIKDPKNQVGKEVICQV 216
Cdd:cd00096   1 VTLTCSASGNPPPTITWYKNGKPLPPSSR---DSRRSELGNGTLTISNVTLEDSGTYTCVA 58
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-140 9.05e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 35.13  E-value: 9.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400    45 TPASLKCSLQN--AQEALIVTWQKKKA-VSPENMVTFSENHGVviQPAYKDKINITQLGLQNS-TITFWNITLEDEGCYM 120
Cdd:pfam07686  12 GSVTLPCTYSSsmSEASTSVYWYRQPPgKGPTFLIAYYSNGSE--EGVKKGRFSGRGDPSNGDgSLTIQNLTLSDSGTYT 89

                          90       100
                  ....*....|....*....|
gi 21411400   121 CLFNTFGFGKISGTACLTVY 140
Cdd:pfam07686  90 CAVIPSGEGVFGKGTRLTVL 109
PHA02914 PHA02914
Immunoglobulin-like domain protein; Provisional
 21-225 9.50e-03

Immunoglobulin-like domain protein; Provisional


Pssm-ID: 165230  Cd Length: 500  Bit Score: 37.01  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400   21 VMAAVVLCTAQVQVVTQDEREQLytpaSLKCSLQNAQEALIVTWQKKKAVSPENMVTFSenhgvvIQPAYKDKINITQLG 100
Cdd:PHA02914   8 IIFAVCCASESYNIFLRNEDEEL----ALTCILPAAKMADKVVLIKGNDMNNTKEIESS------INNAGEDNVCYCGDP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21411400  101 LQNSTITFWNITLEDEGCYMCLFNtfgFGK-ISGTACLTVYVQPIVSLHY-KFSEDHLNITCSATA---RPAPMVFWKVP 175
Cdd:PHA02914  78 DKEYSFIEENIGEHEDGDFKCIFY---LGDnESHKHEILVRKAPKIDTTFlEFNDKHTCICCKIDKpmnQDALKVFFVAG 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 21411400  176 RSGIENSTVTLSHPNGTTSVTSILHIKDPK-NQVGKEVICQVLHLGTVTDF 225
Cdd:PHA02914 155 GVNVDGNFLGKKDFNNDPSNRTVKLCADKShDDTAREALCGVEYFGALKEL 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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