NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18044946|gb|AAH20219|]
View 

ZNF143 protein [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-412 1.22e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 239 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 314
Cdd:COG5048 273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 315 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 389
Cdd:COG5048 352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                       170       180
                ....*....|....*....|...
gi 18044946 390 SSLYKHHVVHTHSKPYNCNHCGK 412
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-412 1.22e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 239 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 314
Cdd:COG5048 273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 315 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 389
Cdd:COG5048 352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                       170       180
                ....*....|....*....|...
gi 18044946 390 SSLYKHHVVHTHSKPYNCNHCGK 412
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-328 1.13e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.13e-05
                          10        20
                  ....*....|....*....|....*...
gi 18044946   301 DLQKHIRTHTGERPFKCPFegCGRSFTT 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-412 1.22e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 239 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 314
Cdd:COG5048 273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 315 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 389
Cdd:COG5048 352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                       170       180
                ....*....|....*....|...
gi 18044946 390 SSLYKHHVVHTHSKPYNCNHCGK 412
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
343-418 4.80e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.80e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18044946 343 RPYYCtePGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQIS 418
Cdd:COG5048  32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 371-428 1.05e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 1.05e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18044946 371 GEKPYVCTVPGCDKRFTEYSSLyKHHVVHTH--------------------SKPYNCNHCGKTYKQISTLVMHKRTAH 428
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHqnqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 237-401 1.68e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 53.95  E-value: 1.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 237 TTAHHLKVHERSHTGDRPYQCEHAGCGK---AFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIrthtGER 313
Cdd:COG5189 273 SQGSAELFEESSLGFDYEFIHKSVGNKEirgGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLKVK----DGK 348

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 314 PFKCPFEGCGRSFTTSNIRKVHvRTHTGERPYYCTEPgcgrafasatNYKNHVRIHTGEKPYVCTVpgCDKRFTEYSSLy 393
Cdd:COG5189 349 PYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENP----------SPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL- 414


                ....*...
gi 18044946 394 KHHVVHTH 401
Cdd:COG5189 415 KYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
252-310 2.53e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.53e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18044946 252 DRPYQCEhaGCGKAFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHT 310
Cdd:COG5048  31 PRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
347-430 6.34e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 347 CTEPGCGRAFASATNYKNHVR--IHTGE--KPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNC--NHCGKTYKQIST- 419
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNn 369

                        90
                ....*....|....*
gi 18044946 420 ----LVMHKRTAHND 430
Cdd:COG5048 370 eppqSLQQYKDLKND 384
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-328 1.13e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.13e-05
                          10        20
                  ....*....|....*....|....*...
gi 18044946   301 DLQKHIRTHTGERPFKCPFegCGRSFTT 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-396 1.42e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 220 SGEKAFRCEYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKafatgyglkshvrTHTGEKPYrcsednctksfKTS 299
Cdd:COG5048 317 ESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS-------------KFSPLLNN-----------EPP 372

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 300 GDLQKHIRTHTgERPFKCPFEGCGRSFTTSNIRKVHVRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCtv 379
Cdd:COG5048 373 QSLQQYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                       170
                ....*....|....*..
gi 18044946 380 pgCDKRFTEYSSLYKHH 396
Cdd:COG5048 450 --SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-298 1.68e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.68e-05
                          10        20
                  ....*....|....*....|....*..
gi 18044946   272 LKSHVRTHTGEKPYRCSEdnCTKSFKT 298
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-433 2.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 283 KPYRCseDNCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTgERPYYCTEPGCGRAFASATNY 362
Cdd:COG5048  32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH-NNPSDLNSKSLPLSNSKASSS 108

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18044946 363 KNHvrIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---KPYNCNHCGKTYKQISTLVMHKRTAHNDTEP 433
Cdd:COG5048 109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLrnnPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP 180
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 257-344 3.67e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 42.79  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946   257 CEHAGCGKAFATGYGLKSHVRTHTGE------KPYRCSEDNCTKSFKTSGDLQKHIRTH-TGERPFKCpfEGCGRSFTT- 328
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 18044946   329 -SNIRKVHVRTHTGERP 344
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-268 1.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.20e-04
                          10        20
                  ....*....|....*....|....*...
gi 18044946   241 HLKVHERSHTGDRPYQCEHagCGKAFAT 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-280 1.32e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.32e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18044946 221 GEKAFRCEYDGCGKLYTTAHHLKVH---------------ERSHTG----DRPYQCEHagCGKAFATGYGLKSHvRTHT 280
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
361-387 1.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.69e-04
                          10        20
                  ....*....|....*....|....*..
gi 18044946   361 NYKNHVRIHTGEKPYVCTVpgCDKRFT 387
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 287-403 1.35e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946   287 CSEDNCTKSFKTSGDLQKHIRTHTgerPFKCPFEGcgrsfttsnirkvhvrthtgeRPYYCTEPGCGRAFASATNYKNHV 366
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHC---PPTQSLEG---------------------KLFRCSALSCTETFPSMQELVAHS 57

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 18044946   367 RIHTGEKPYVcTVPGCDKRFTEYSSLYKH-HVVHTHSK 403
Cdd:pfam15909  58 KLHYKPNRYF-KCENCLLRFRTHRSLFKHlHVCAEHAQ 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 285-309 1.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*
gi 18044946   285 YRCSEdnCTKSFKTSGDLQKHIRTH 309
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-358 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 18044946   333 KVHVRTHTGERPYYCTEpgCGRAFAS 358
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-302 2.19e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044946 209 HATRVTAKS-QQSGEKAFRCEY-DGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYR 286
Cdd:COG5048  14 SVLSSTPKStLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93

                        90
                ....*....|....*.
gi 18044946 287 CSEDNCTKSFKTSGDL 302
Cdd:COG5048  94 NSKSLPLSNSKASSSS 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH