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Conserved domains on  [gi|18044039|gb|AAH19369|]
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RIKEN cDNA 1500041N16 gene [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-304 3.33e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.09  E-value: 3.33e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  19 KTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVAT 98
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDcrSRKPEPVQTLDEARDGISSVKVSDHE--ILAGSVDGRVR 176
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 177 RYDLRMGQVSSDYVG--GPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQQYklDCCLSERDTHVVSCS 254
Cdd:cd00200 161 LWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN--SVAFSPDGYLLASGS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 18044039 255 EDGKVFFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTA-MGGSIQYWR 304
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGsADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-304 3.33e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.09  E-value: 3.33e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  19 KTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVAT 98
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDcrSRKPEPVQTLDEARDGISSVKVSDHE--ILAGSVDGRVR 176
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 177 RYDLRMGQVSSDYVG--GPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQQYklDCCLSERDTHVVSCS 254
Cdd:cd00200 161 LWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN--SVAFSPDGYLLASGS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 18044039 255 EDGKVFFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTA-MGGSIQYWR 304
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGsADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-307 6.55e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 6.55e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  25 QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRK 104
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 105 FRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEILA-GSVDGRVRRYDLRM 182
Cdd:COG2319 200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSpDGRLLAsGSADGTVRLWDLAT 277

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 183 GQVSSDYVG--GPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQQYKLdcCLSERDTHVVSCSEDGKV 259
Cdd:COG2319 278 GELLRTLTGhsGGVNSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTV 354

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 18044039 260 FFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTA-MGGSIQYWREET 307
Cdd:COG2319 355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGsADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 24-277 3.00e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.34  E-value: 3.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039   24 SQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPlrGTLLRTYSGHGYEVLDAAG----------SFDNSHLCSGGGDKTVVL 93
Cdd:PLN00181 482 SSNLVCAIGFDRDGEFFATAGVNKKIKIFEC--ESIIKDGRDIHYPVVELASrsklsgicwnSYIKSQVASSNFEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039   94 WDVATGQVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSVRCWDCrsRKPEPVQTLdEARDGISSVKV---SDHEILAG 169
Cdd:PLN00181 560 WDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSI--NQGVSIGTI-KTKANICCVQFpseSGRSLAFG 636

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  170 SVDGRVRRYDLRMGQVSSDYVGGPITCTCFSR--DGQCTLISSLDSTLRLLDKDTG------ELLGEYVGHKNqqYKLDC 241
Cdd:PLN00181 637 SADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRfvDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTN--VKNFV 714

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 18044039  242 CLSERDTHVVSCSEDGKVFFWDlvegaLALALPVGS 277
Cdd:PLN00181 715 GLSVSDGYIATGSETNEVFVYH-----KAFPMPVLS 745
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 1.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18044039     98 TGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 2.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18044039    99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-304 3.33e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.09  E-value: 3.33e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  19 KTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVAT 98
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDcrSRKPEPVQTLDEARDGISSVKVSDHE--ILAGSVDGRVR 176
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 177 RYDLRMGQVSSDYVG--GPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQQYklDCCLSERDTHVVSCS 254
Cdd:cd00200 161 LWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN--SVAFSPDGYLLASGS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 18044039 255 EDGKVFFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTA-MGGSIQYWR 304
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGsADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-307 6.55e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 6.55e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  25 QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRK 104
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 105 FRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEILA-GSVDGRVRRYDLRM 182
Cdd:COG2319 200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSpDGRLLAsGSADGTVRLWDLAT 277

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 183 GQVSSDYVG--GPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQQYKLdcCLSERDTHVVSCSEDGKV 259
Cdd:COG2319 278 GELLRTLTGhsGGVNSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTV 354

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 18044039 260 FFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTA-MGGSIQYWREET 307
Cdd:COG2319 355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGsADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
16-264 8.86e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 8.86e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  16 KRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  96 VATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRkpEPVQTLDEARDGISSVKVS-DHEILA-GSVDG 173
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNSVAFSpDGKLLAsGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 174 RVRRYDLRMGQVSSDYVG--GPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQQYklDCCLSERDTHVV 251
Cdd:COG2319 311 TVRLWDLATGKLLRTLTGhtGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGRTLA 388

                       250
                ....*....|...
gi 18044039 252 SCSEDGKVFFWDL 264
Cdd:COG2319 389 SGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
9-304 1.62e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.71  E-value: 1.62e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039   9 RAPELPQKRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGD 88
Cdd:COG2319  62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  89 KTVVLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEIL 167
Cdd:COG2319 142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSpDGKLL 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 168 A-GSVDGRVRRYDLRMGQVSSDYVG--GPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQQYKLdcCL 243
Cdd:COG2319 220 AsGSADGTVRLWDLATGKLLRTLTGhsGSVRSVAFSPDGR-LLASgSADGTVRLWDLATGELLRTLTGHSGGVNSV--AF 296

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18044039 244 SERDTHVVSCSEDGKVFFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTA-MGGSIQYWR 304
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGsDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
26-303 1.59e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 1.59e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  26 GAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKF 105
Cdd:COG2319  37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 106 RGHAGKVNTVQFNEEATVILSGSIDSSVRCWDcrSRKPEPVQTLDEARDGISSVKVS-DHEILA-GSVDGRVRRYDLRMG 183
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSpDGKLLAsGSDDGTVRLWDLATG 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 184 QVSSDYVG--GPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQQYKLDccLSERDTHVVSCSEDGKVF 260
Cdd:COG2319 195 KLLRTLTGhtGAVRSVAFSPDGK-LLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVA--FSPDGRLLASGSADGTVR 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 18044039 261 FWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTA-MGGSIQYW 303
Cdd:COG2319 272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGsDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-309 6.37e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 6.37e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  59 LLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDc 138
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 139 rSRKPEPVQTLDEARDGISSVKVSDHE--ILAGSVDGRVRRYDLRMGQVSSDYVG--GPITCTCFSRDGQCTLISSLDST 214
Cdd:cd00200  80 -LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 215 LRLLDKDTGELLGEYVGHKNQQYKldCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLT 294
Cdd:cd00200 159 IKLWDLRTGKCVATLTGHTGEVNS--VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                       250
                ....*....|....*.
gi 18044039 295 A-MGGSIQYWREETYE 309
Cdd:cd00200 237 GsEDGTIRVWDLRTGE 252
WD40 COG2319
WD40 repeat [General function prediction only];
15-181 7.75e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 7.75e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  15 QKRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLW 94
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  95 DVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEILA-GSVD 172
Cdd:COG2319 316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSpDGRTLAsGSAD 393


                ....*....
gi 18044039 173 GRVRRYDLR 181
Cdd:COG2319 394 GTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
32-304 1.56e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 1.56e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  32 RFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKFRGHAGK 111
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 112 VNTVQFNEEATVILSGSIDSSVRCWDCRSrkPEPVQTLDEARDGISSVKVS-DHEILA-GSVDGRVRRYDLRMGQVSSDY 189
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVAFSpDGKTLAsGSADGTVRLWDLATGKLLRTL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 190 VG--GPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQQYKLdcCLSERDTHVVSCSEDGKVFFWDLVE 266
Cdd:COG2319 159 TGhsGAVTSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDLAT 235

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 18044039 267 GALALALPVGSNVVQSLAYHPTEPCLLTAMG-GSIQYWR 304
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-137 2.94e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 2.94e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  16 KRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 18044039  96 VATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:cd00200 248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
16-98 1.21e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 1.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  16 KRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                ...
gi 18044039  96 VAT 98
Cdd:COG2319 401 LAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 24-277 3.00e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.34  E-value: 3.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039   24 SQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPlrGTLLRTYSGHGYEVLDAAG----------SFDNSHLCSGGGDKTVVL 93
Cdd:PLN00181 482 SSNLVCAIGFDRDGEFFATAGVNKKIKIFEC--ESIIKDGRDIHYPVVELASrsklsgicwnSYIKSQVASSNFEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039   94 WDVATGQVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSVRCWDCrsRKPEPVQTLdEARDGISSVKV---SDHEILAG 169
Cdd:PLN00181 560 WDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSI--NQGVSIGTI-KTKANICCVQFpseSGRSLAFG 636

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  170 SVDGRVRRYDLRMGQVSSDYVGGPITCTCFSR--DGQCTLISSLDSTLRLLDKDTG------ELLGEYVGHKNqqYKLDC 241
Cdd:PLN00181 637 SADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRfvDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTN--VKNFV 714

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 18044039  242 CLSERDTHVVSCSEDGKVFFWDlvegaLALALPVGS 277
Cdd:PLN00181 715 GLSVSDGYIATGSETNEVFVYH-----KAFPMPVLS 745
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 1.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18044039     98 TGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 2.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18044039    99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-53 3.43e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 3.43e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18044039     14 PQKRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWN 53
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
16-53 5.48e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.48e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18044039    16 KRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWN 53
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-95 6.50e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 6.50e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 18044039     57 GTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
57-95 6.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 6.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18044039    57 GTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-263 3.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 3.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 18044039    222 TGELLGEYVGHKNQQYklDCCLSERDTHVVSCSEDGKVFFWD 263
Cdd:smart00320   1 SGELLKTLKGHTGPVT--SVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 118-226 3.99e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.44  E-value: 3.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039 118 NEEATVILSGSIDSSVRCWDCRS-RKP--------EPVQTLDEARDGissvkvsdHEILAGSVDGRVRRYDLRMGQVSSD 188
Cdd:cd22857 189 KDDHRKIVTGTGYHQVRLYDTRAqRRPvvsvdfgeTPIKAVAEDPDG--------HTVYVGDTSGDLASIDLRTGKLLGC 260

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 18044039 189 YVG---GPITCTcfSRDGQCTLISS--LDSTLRLLDKDTGELL 226
Cdd:cd22857 261 FKGkcgGSIRSI--ARHPELPLIAScgLDRYLRIWDTETRQLL 301
PTZ00420 PTZ00420
coronin; Provisional
 21-142 8.50e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 8.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039   21 LDCSQGAVrAVRFNVDGNycltcGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAagSFDNSH---LCSGGGDKTVVLWDVA 97
Cdd:PTZ00420  34 IACSSGFV-AVPWEVEGG-----GLIGAIRLENQMRKPPVIKLKGHTSSILDL--QFNPCFseiLASGSEDLTIRVWEIP 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 18044039   98 -TGQVVRK-------FRGHAGKVNTVQFNEEATVIL-SGSIDSSVRCWDCRSRK 142
Cdd:PTZ00420 106 hNDESVKEikdpqciLKGHKKKISIIDWNPMNYYIMcSSGFDSFVNIWDIENEK 159
PTZ00421 PTZ00421
coronin; Provisional
 44-189 8.72e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.65  E-value: 8.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039   44 GSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKFRGHAG----------KVN 113
Cdd:PTZ00421 145 GADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclwakRKD 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044039  114 TVqfneeATVILSGSIDSSVRCWDCRsRKPEPVQTLDEARDGISSVKVSDHE----ILAGSVDGRVRRYDLRMGQVSSDY 189
Cdd:PTZ00421 225 LI-----ITLGCSKSQQRQIMLWDTR-KMASPYSTVDLDQSSALFIPFFDEDtnllYIGSKGEGNIRCFELMNERLTFCS 298
WD40 pfam00400
WD domain, G-beta repeat;
223-263 7.87e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18044039   223 GELLGEYVGHKNQQYklDCCLSERDTHVVSCSEDGKVFFWD 263
Cdd:pfam00400   1 GKLLKTLEGHTGSVT--SLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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