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Conserved domains on  [gi|16041751|gb|AAH15756|]
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Complement factor properdin [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSR pfam18487
Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. ...
 28-77 8.28e-13

Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.


:

Pssm-ID: 408280  Cd Length: 50  Bit Score: 62.69  E-value: 8.28e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 16041751    28 DPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRS 77
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGGVSVEDCCLNPAYGFQEPGGGLCQSCRS 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
140-190 4.32e-11

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 57.81  E-value: 4.32e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 16041751   140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPkCGGHCPGQAQESEACdTQQVC 190
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP-GGEPCTGDDIETQAC-KMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
261-312 1.20e-09

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.58  E-value: 1.20e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16041751   261 GPWGPVSPCPVTCGLGQTMEQRTCNHPVPqhGGPFCAGDATRTHICnTAVPC 312
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC-KMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
81-132 1.20e-06

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 45.10  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 16041751    81 SLWSTWAPCSVTCSEGSQLRYRRCVGW---NGQCSGKVApgtlewQLQACEDQQC 132
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDI------ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 196-255 2.81e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.50  E-value: 2.81e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16041751    196 WATWGPWTPCSASCHGGphepKETRSRKCSAPEPSQkpPGKPCPGLAYEQRRCTgLPPCP 255
Cdd:smart00209   1 WSEWSEWSPCSVTCGGG----VQTRTRSCCSPPPQN--GGGPCTGEDVETRACN-EQPCP 53
 
Name Accession Description Interval E-value
TSR pfam18487
Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. ...
 28-77 8.28e-13

Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.


Pssm-ID: 408280  Cd Length: 50  Bit Score: 62.69  E-value: 8.28e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 16041751    28 DPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRS 77
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGGVSVEDCCLNPAYGFQEPGGGLCQSCRS 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
140-190 4.32e-11

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 57.81  E-value: 4.32e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 16041751   140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPkCGGHCPGQAQESEACdTQQVC 190
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP-GGEPCTGDDIETQAC-KMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 139-191 3.97e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 55.29  E-value: 3.97e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16041751    139 WSGWGPWEPCSVTCSKGTRTRRRAC-NHPAPKCGGHCPGQAQESEACDTqQVCP 191
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCcSPPPQNGGGPCTGEDVETRACNE-QPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
261-312 1.20e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.58  E-value: 1.20e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16041751   261 GPWGPVSPCPVTCGLGQTMEQRTCNHPVPqhGGPFCAGDATRTHICnTAVPC 312
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC-KMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 260-313 7.69e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 7.69e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16041751    260 WGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAvPCP 313
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ-PCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
81-132 1.20e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 45.10  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 16041751    81 SLWSTWAPCSVTCSEGSQLRYRRCVGW---NGQCSGKVApgtlewQLQACEDQQC 132
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDI------ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 196-255 2.81e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.50  E-value: 2.81e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16041751    196 WATWGPWTPCSASCHGGphepKETRSRKCSAPEPSQkpPGKPCPGLAYEQRRCTgLPPCP 255
Cdd:smart00209   1 WSEWSEWSPCSVTCGGG----VQTRTRSCCSPPPQN--GGGPCTGEDVETRACN-EQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 142-182 6.58e-06

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 48.42  E-value: 6.58e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 16041751  142 WGPWEPCSVTCSKGTRTRRRACNHpaPKCGGHCPGQAQESE 182
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSRPILH--EGCTTHMVEECEEEE 281
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 80-132 1.91e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 1.91e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 16041751     80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEwQLQACEDQQC 132
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV-ETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
199-254 9.18e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 34.32  E-value: 9.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16041751   199 WGPWTPCSASCHGGphepKETRSRKCsapePSQKPPGKPCPGLAYEQRRCTgLPPC 254
Cdd:pfam00090   3 WSPWSPCSVTCGKG----IQVRQRTC----KSPFPGGEPCTGDDIETQACK-MDKC 49
 
Name Accession Description Interval E-value
TSR pfam18487
Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. ...
 28-77 8.28e-13

Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.


Pssm-ID: 408280  Cd Length: 50  Bit Score: 62.69  E-value: 8.28e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 16041751    28 DPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRS 77
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGGVSVEDCCLNPAYGFQEPGGGLCQSCRS 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
140-190 4.32e-11

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 57.81  E-value: 4.32e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 16041751   140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPkCGGHCPGQAQESEACdTQQVC 190
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP-GGEPCTGDDIETQAC-KMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 139-191 3.97e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 55.29  E-value: 3.97e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16041751    139 WSGWGPWEPCSVTCSKGTRTRRRAC-NHPAPKCGGHCPGQAQESEACDTqQVCP 191
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCcSPPPQNGGGPCTGEDVETRACNE-QPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
261-312 1.20e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.58  E-value: 1.20e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16041751   261 GPWGPVSPCPVTCGLGQTMEQRTCNHPVPqhGGPFCAGDATRTHICnTAVPC 312
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC-KMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 260-313 7.69e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 7.69e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16041751    260 WGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAvPCP 313
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ-PCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
81-132 1.20e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 45.10  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 16041751    81 SLWSTWAPCSVTCSEGSQLRYRRCVGW---NGQCSGKVApgtlewQLQACEDQQC 132
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDI------ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 196-255 2.81e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.50  E-value: 2.81e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16041751    196 WATWGPWTPCSASCHGGphepKETRSRKCSAPEPSQkpPGKPCPGLAYEQRRCTgLPPCP 255
Cdd:smart00209   1 WSEWSEWSPCSVTCGGG----VQTRTRSCCSPPPQN--GGGPCTGEDVETRACN-EQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 142-182 6.58e-06

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 48.42  E-value: 6.58e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 16041751  142 WGPWEPCSVTCSKGTRTRRRACNHpaPKCGGHCPGQAQESE 182
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSRPILH--EGCTTHMVEECEEEE 281
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 80-132 1.91e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 1.91e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 16041751     80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEwQLQACEDQQC 132
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV-ETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 140-188 6.80e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.34  E-value: 6.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 16041751   140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQaQESEACDTQQ 188
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPP 51
TSP_1 pfam00090
Thrombospondin type 1 domain;
199-254 9.18e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 34.32  E-value: 9.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16041751   199 WGPWTPCSASCHGGphepKETRSRKCsapePSQKPPGKPCPGLAYEQRRCTgLPPC 254
Cdd:pfam00090   3 WSPWSPCSVTCGKG----IQVRQRTC----KSPFPGGEPCTGDDIETQACK-MDKC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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