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Conserved domains on  [gi|15215167|gb|AAH12688|]
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Thumpd3 protein [Mus musculus]

Protein Classification

RNA methyltransferase( domain architecture ID 10185016)

SAM-dependent RNA methyltransferase containing a THUMP domain, similar to Methanocaldococcus jannaschii Trm14, a tRNA m2G6-methyltransferase and eukaryotic THUMPD3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 294-479 1.00e-78

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


:

Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 243.80  E-value: 1.00e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   294 RNITHF-GPTTLRSTLAYGMLRLCEPKPTDVIVDPMCGTGAIPIEGATEWSHCYHIAGDNNPLAVNRAANNISSLLTKSQ 372
Cdd:pfam01170   1 RGYRPFnGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIAPGKFDARVRAPLYGSDIDRRMVQGAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   373 IKDGKTSWGLPIDAVQWDICNLPLRTASVDIIVTDMPFGKRMGSKKRNWNLYPACLREMSRVCRPGtGRAVLLTQDKKCF 452
Cdd:pfam01170  81 LNAENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALEALYPEFLREAKRVLRGG-GWLVLLTAENKDF 159

                         170       180
                  ....*....|....*....|....*..
gi 15215167   453 TKALSGMGhvWRKVHVVWVNIGGLHAA 479
Cdd:pfam01170 160 EKAARERA--WRKKKEFNVHIGGTRVI 184
THUMP_AdoMetMT cd11715
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of ...
 41-287 9.94e-14

THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of this family contain an N-terminal THUMP domain and a C-terminal S-adenosylmethionine-dependent methyltransferase domain. Members have been implicated in the modification of 23S RNA m2G2445, a highly conserved modification in bacteria and in the m2G6 modification of tRNA. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


:

Pssm-ID: 212584  Cd Length: 152  Bit Score: 68.76  E-value: 9.94e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167  41 IGATVPTGFEQTAAGEVREKLksACRISKDRGKIYFDIAVESLAQV-HCLRSVDNLFVVVQEFKDYQFKDtkeevlrdFE 119
Cdd:cd11715   1 FFATCPPGLEELLAAELKALG--AEDVEVGPGGVSFEGDLEDAYRAnLWLRTAHRVLLLLAEFEAEDFDD--------LY 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 120 ELAGKLPWSDPLKVWQinttfkkkkakrrkanqsagkekadcgqgdkadekdgkkkhasstsdshildyyenpaikeeis 199
Cdd:cd11715  71 ELAKAIDWEDYLDPDG---------------------------------------------------------------- 86

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 200 tlvgdvlssckdetgqslreetepqvqKFRVTCNRAGEkHCFTSNEAARDFGGAIQEYFK-----WKADMTNFDVEVLLN 274
Cdd:cd11715  87 ---------------------------TFAVRATRVGS-KLFHSQFAALRVKDAIVDRFRekgkrPSVDLDNPDVRIRVH 138

                       250
                ....*....|...
gi 15215167 275 IHDNEVIVAIALT 287
Cdd:cd11715 139 LSKDRATLSLDLS 151
 
Name Accession Description Interval E-value
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 294-479 1.00e-78

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 243.80  E-value: 1.00e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   294 RNITHF-GPTTLRSTLAYGMLRLCEPKPTDVIVDPMCGTGAIPIEGATEWSHCYHIAGDNNPLAVNRAANNISSLLTKSQ 372
Cdd:pfam01170   1 RGYRPFnGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIAPGKFDARVRAPLYGSDIDRRMVQGAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   373 IKDGKTSWGLPIDAVQWDICNLPLRTASVDIIVTDMPFGKRMGSKKRNWNLYPACLREMSRVCRPGtGRAVLLTQDKKCF 452
Cdd:pfam01170  81 LNAENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALEALYPEFLREAKRVLRGG-GWLVLLTAENKDF 159

                         170       180
                  ....*....|....*....|....*..
gi 15215167   453 TKALSGMGhvWRKVHVVWVNIGGLHAA 479
Cdd:pfam01170 160 EKAARERA--WRKKKEFNVHIGGTRVI 184
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 298-449 5.73e-25

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 101.18  E-value: 5.73e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 298 HFGPTTLRSTLAYGMLRLCEPKPTDVIVDPMCGTGAIPIEGAteWSHCYHIAGDNNPLAVNRAANNISSLLTKSqikdgk 377
Cdd:COG1041   4 FFYPGSLDPRLARALVNLAGAKEGDTVLDPFCGTGTILIEAG--LLGRRVIGSDIDPKMVEGARENLEHYGYED------ 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15215167 378 tswglpIDAVQWDICNLPLRTASVDIIVTDMPFGKRMGSKKRNW-NLYPACLREMSRVCRPGtGRAVLLTQDK 449
Cdd:COG1041  76 ------ADVIRGDARDLPLADESVDAIVTDPPYGRSSKISGEELlELYEKALEEAARVLKPG-GRVVIVTPRD 141
THUMP_AdoMetMT cd11715
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of ...
 41-287 9.94e-14

THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of this family contain an N-terminal THUMP domain and a C-terminal S-adenosylmethionine-dependent methyltransferase domain. Members have been implicated in the modification of 23S RNA m2G2445, a highly conserved modification in bacteria and in the m2G6 modification of tRNA. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212584  Cd Length: 152  Bit Score: 68.76  E-value: 9.94e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167  41 IGATVPTGFEQTAAGEVREKLksACRISKDRGKIYFDIAVESLAQV-HCLRSVDNLFVVVQEFKDYQFKDtkeevlrdFE 119
Cdd:cd11715   1 FFATCPPGLEELLAAELKALG--AEDVEVGPGGVSFEGDLEDAYRAnLWLRTAHRVLLLLAEFEAEDFDD--------LY 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 120 ELAGKLPWSDPLKVWQinttfkkkkakrrkanqsagkekadcgqgdkadekdgkkkhasstsdshildyyenpaikeeis 199
Cdd:cd11715  71 ELAKAIDWEDYLDPDG---------------------------------------------------------------- 86

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 200 tlvgdvlssckdetgqslreetepqvqKFRVTCNRAGEkHCFTSNEAARDFGGAIQEYFK-----WKADMTNFDVEVLLN 274
Cdd:cd11715  87 ---------------------------TFAVRATRVGS-KLFHSQFAALRVKDAIVDRFRekgkrPSVDLDNPDVRIRVH 138

                       250
                ....*....|...
gi 15215167 275 IHDNEVIVAIALT 287
Cdd:cd11715 139 LSKDRATLSLDLS 151
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 222-284 1.99e-13

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 65.76  E-value: 1.99e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15215167    222 EPQVQKFRVTCNRAGEKHCFTSNEAARDFGGAIQE-YFKWKADMTNFDVEVLLNIHDNEVIVAI 284
Cdd:smart00981  19 FKEGKTFAVRAKRRGKNHEFTSLEVKRAIGDKLLEkTGGRKVDLKNPDVVIRVELRKDKAYLSI 82
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
 243-444 2.02e-11

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 65.15  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   243 SNEAARDFGGAIQEYfKWKADMTNFDVEVLLNIHDNEVIVAIALT--------EESLHRRniTHFGPTTLRSTLAYGMLR 314
Cdd:TIGR01177 100 KARLERKIGAILKKK-GFKVSLRRPDIVVRVVITEDIFYLGRVLEerdkeqfiERKPDRR--PFFKPGSMDPKLARAMVN 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   315 LCEPKPTDVIVDPMCGTGAIPIEGATEWSHCyhIAGDNNPLAVNRAANNisslLTKSQIKDGKTSwglpidavQWDICNL 394
Cdd:TIGR01177 177 LARVTEGDRVLDPFCGTGGFLIEAGLMGAKV--IGCDIDWKMVAGARIN----LEHYGIEDFFVK--------RGDATKL 242

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15215167   395 PLRTASVDIIVTDMPFGkRMGSKKRNWN--LYPACLREMSRVCRPGTGRAVL 444
Cdd:TIGR01177 243 PLSSESVDAIATDPPYG-RSTTAAGDGLesLYERSLEEFHEVLKSEGWIVYA 293
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 202-284 4.23e-11

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 60.91  E-value: 4.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   202 VGDVLSSCKDETGQSLREETEPQVQKFRVTCNRAGEKHCFTSNEAARDFGGAIQEYFKWKADMTNFDVEVLLNIHDNEVI 281
Cdd:pfam02926  59 CEADLEDILELAKEIIKDKFKKEGETFAVRVKRRGKNHEFTSLEINREVGKAIVEKTGLKVDLENPDIVVHVEIIKDKAY 138


                  ...
gi 15215167   282 VAI 284
Cdd:pfam02926 139 ISI 141
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 239-339 7.38e-09

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 58.28  E-value: 7.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167  239 HCFTSNEAARD--FGG-----AIQEYFKWKA------DMTNFDVEVLLNIHDNEVIVAIALTEESLHRRNI-THFGPTTL 304
Cdd:PRK11783  94 DFSGTNDEIRNtqFGAlkvkdAIVDRFRRKGgprpsvDKEQPDIRINARLNKGEATISLDLSGESLHQRGYrQATGEAPL 173

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15215167  305 RSTLAYGML-RLCEPKPTDVIVDPMCGTGAIPIEGA 339
Cdd:PRK11783 174 KENLAAAILlRSGWPQEGTPLLDPMCGSGTLLIEAA 209
ThiI COG0301
Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) [Coenzyme ...
 228-282 3.63e-07

Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]; Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440070 [Multi-domain]  Cd Length: 382  Bit Score: 52.40  E-value: 3.63e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15215167 228 FRVTCNRAGEKHCFTSNEAARDFGGAIQEYFK-WKADMTNFDVEVLLNIHDNEVIV 282
Cdd:COG0301 103 FKVRAKRAGKHFPFTSPELEREVGGALLENTPgLKVDLKNPDVTIRVEVRDDKAYV 158
 
Name Accession Description Interval E-value
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 294-479 1.00e-78

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 243.80  E-value: 1.00e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   294 RNITHF-GPTTLRSTLAYGMLRLCEPKPTDVIVDPMCGTGAIPIEGATEWSHCYHIAGDNNPLAVNRAANNISSLLTKSQ 372
Cdd:pfam01170   1 RGYRPFnGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIAPGKFDARVRAPLYGSDIDRRMVQGAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   373 IKDGKTSWGLPIDAVQWDICNLPLRTASVDIIVTDMPFGKRMGSKKRNWNLYPACLREMSRVCRPGtGRAVLLTQDKKCF 452
Cdd:pfam01170  81 LNAENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALEALYPEFLREAKRVLRGG-GWLVLLTAENKDF 159

                         170       180
                  ....*....|....*....|....*..
gi 15215167   453 TKALSGMGhvWRKVHVVWVNIGGLHAA 479
Cdd:pfam01170 160 EKAARERA--WRKKKEFNVHIGGTRVI 184
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 298-449 5.73e-25

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 101.18  E-value: 5.73e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 298 HFGPTTLRSTLAYGMLRLCEPKPTDVIVDPMCGTGAIPIEGAteWSHCYHIAGDNNPLAVNRAANNISSLLTKSqikdgk 377
Cdd:COG1041   4 FFYPGSLDPRLARALVNLAGAKEGDTVLDPFCGTGTILIEAG--LLGRRVIGSDIDPKMVEGARENLEHYGYED------ 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15215167 378 tswglpIDAVQWDICNLPLRTASVDIIVTDMPFGKRMGSKKRNW-NLYPACLREMSRVCRPGtGRAVLLTQDK 449
Cdd:COG1041  76 ------ADVIRGDARDLPLADESVDAIVTDPPYGRSSKISGEELlELYEKALEEAARVLKPG-GRVVIVTPRD 141
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 226-456 1.35e-19

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 90.16  E-value: 1.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 226 QKFRVTCNRAGEKHcFTSNEAARDFGGAIQEYFKWKA------DMTNFDVEVLLNIHDNEVIVAIALTEESLHRRN---I 296
Cdd:COG0116  88 GTFAVDATSVKSKL-FHSQFAALRVKDAIVDRFREKYgarpsvDEDGPDVRIHVHLLKDRATLSLDTSGESLHKRGyreA 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 297 THFGPttLRSTLAYGMLRLCEPKPTDVIVDPMCGTGAIPIEGA----------------TEWSHC--------------- 345
Cdd:COG0116 167 QGEAP--LKETLAAALLLLSGWDGDRPLVDPMCGSGTILIEAAliaaniapglnrdfafEKWPDFdaelwqelreeaear 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 346 ------YHIAG-DNNPLAVNRAANNISSLltksqikdgktswGLP--IDAVQWDICNLPlRTASVDIIVTDMPFGKRMGS 416
Cdd:COG0116 245 ikrdppLPIFGsDIDPRAIEAARENAERA-------------GVAdlIEFEQADFRDLE-PPAEPGLIITNPPYGERLGE 310

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 15215167 417 KKRNWNLYpaclREMSRVCRP--GTGRAVLLTQDKKcFTKAL 456
Cdd:COG0116 311 EEELEALY----RELGDVLKQrfKGWSAYILTSDPE-LEKAI 347
THUMP_AdoMetMT cd11715
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of ...
 41-287 9.94e-14

THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of this family contain an N-terminal THUMP domain and a C-terminal S-adenosylmethionine-dependent methyltransferase domain. Members have been implicated in the modification of 23S RNA m2G2445, a highly conserved modification in bacteria and in the m2G6 modification of tRNA. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212584  Cd Length: 152  Bit Score: 68.76  E-value: 9.94e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167  41 IGATVPTGFEQTAAGEVREKLksACRISKDRGKIYFDIAVESLAQV-HCLRSVDNLFVVVQEFKDYQFKDtkeevlrdFE 119
Cdd:cd11715   1 FFATCPPGLEELLAAELKALG--AEDVEVGPGGVSFEGDLEDAYRAnLWLRTAHRVLLLLAEFEAEDFDD--------LY 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 120 ELAGKLPWSDPLKVWQinttfkkkkakrrkanqsagkekadcgqgdkadekdgkkkhasstsdshildyyenpaikeeis 199
Cdd:cd11715  71 ELAKAIDWEDYLDPDG---------------------------------------------------------------- 86

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 200 tlvgdvlssckdetgqslreetepqvqKFRVTCNRAGEkHCFTSNEAARDFGGAIQEYFK-----WKADMTNFDVEVLLN 274
Cdd:cd11715  87 ---------------------------TFAVRATRVGS-KLFHSQFAALRVKDAIVDRFRekgkrPSVDLDNPDVRIRVH 138

                       250
                ....*....|...
gi 15215167 275 IHDNEVIVAIALT 287
Cdd:cd11715 139 LSKDRATLSLDLS 151
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 222-284 1.99e-13

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 65.76  E-value: 1.99e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15215167    222 EPQVQKFRVTCNRAGEKHCFTSNEAARDFGGAIQE-YFKWKADMTNFDVEVLLNIHDNEVIVAI 284
Cdd:smart00981  19 FKEGKTFAVRAKRRGKNHEFTSLEVKRAIGDKLLEkTGGRKVDLKNPDVVIRVELRKDKAYLSI 82
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
 243-444 2.02e-11

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 65.15  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   243 SNEAARDFGGAIQEYfKWKADMTNFDVEVLLNIHDNEVIVAIALT--------EESLHRRniTHFGPTTLRSTLAYGMLR 314
Cdd:TIGR01177 100 KARLERKIGAILKKK-GFKVSLRRPDIVVRVVITEDIFYLGRVLEerdkeqfiERKPDRR--PFFKPGSMDPKLARAMVN 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   315 LCEPKPTDVIVDPMCGTGAIPIEGATEWSHCyhIAGDNNPLAVNRAANNisslLTKSQIKDGKTSwglpidavQWDICNL 394
Cdd:TIGR01177 177 LARVTEGDRVLDPFCGTGGFLIEAGLMGAKV--IGCDIDWKMVAGARIN----LEHYGIEDFFVK--------RGDATKL 242

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15215167   395 PLRTASVDIIVTDMPFGkRMGSKKRNWN--LYPACLREMSRVCRPGTGRAVL 444
Cdd:TIGR01177 243 PLSSESVDAIATDPPYG-RSTTAAGDGLesLYERSLEEFHEVLKSEGWIVYA 293
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 202-284 4.23e-11

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 60.91  E-value: 4.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   202 VGDVLSSCKDETGQSLREETEPQVQKFRVTCNRAGEKHCFTSNEAARDFGGAIQEYFKWKADMTNFDVEVLLNIHDNEVI 281
Cdd:pfam02926  59 CEADLEDILELAKEIIKDKFKKEGETFAVRVKRRGKNHEFTSLEINREVGKAIVEKTGLKVDLENPDIVVHVEIIKDKAY 138


                  ...
gi 15215167   282 VAI 284
Cdd:pfam02926 139 ISI 141
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 312-446 1.65e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 59.24  E-value: 1.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 312 MLRLCEPKPTDVIVDPMCGTGAIPIEGAtewSHCYHIAG-DNNPLAVNRAANNISSLltksqikdgktswGLPIDAVQWD 390
Cdd:COG2226  14 LLAALGLRPGARVLDLGCGTGRLALALA---ERGARVTGvDISPEMLELARERAAEA-------------GLNVEFVVGD 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15215167 391 ICNLPLRTASVDIIVTDMPFgkrmgskkRNWNLYPACLREMSRVCRPGtGRAVLLT 446
Cdd:COG2226  78 AEDLPFPDGSFDLVISSFVL--------HHLPDPERALAEIARVLKPG-GRLVVVD 124
THUMP_ThiI cd11716
THUMP domain of thiamine biosynthesis protein ThiI; ThiI is an enzyme responsible for the ...
 193-282 6.63e-09

THUMP domain of thiamine biosynthesis protein ThiI; ThiI is an enzyme responsible for the formation of the modified base S(4)U (4-thiouridine) found at position 8 in some prokaryotic tRNAs. This modification acts as a signal for UV exposure, triggering a response that provides protection against its damaging effects. ThiI consists of an N-terminal THUMP domain, followed by an NFLD domain, and a C-terminal PP-loop pyrophosphatase domain. The N-terminal THUMP domain has been implicated in the recognition of the acceptor-stem region. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212585  Cd Length: 166  Bit Score: 55.15  E-value: 6.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167 193 AIKEEISTLVGDVLSSCKdetgqslreetepqvqKFRVTCNRAGEKHCFTSNEAARDFGGAIQEYFK-WKADMTNFDVEV 271
Cdd:cd11716  83 DIKEAALELLKEELKKGK----------------TFKVRAKRADKSFPFTSMEINREVGAALLENTPdLKVDLKNPDVTI 146

                        90
                ....*....|.
gi 15215167 272 LLNIHDNEVIV 282
Cdd:cd11716 147 RVEIREDGAYV 157
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 239-339 7.38e-09

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 58.28  E-value: 7.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167  239 HCFTSNEAARD--FGG-----AIQEYFKWKA------DMTNFDVEVLLNIHDNEVIVAIALTEESLHRRNI-THFGPTTL 304
Cdd:PRK11783  94 DFSGTNDEIRNtqFGAlkvkdAIVDRFRRKGgprpsvDKEQPDIRINARLNKGEATISLDLSGESLHQRGYrQATGEAPL 173

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15215167  305 RSTLAYGML-RLCEPKPTDVIVDPMCGTGAIPIEGA 339
Cdd:PRK11783 174 KENLAAAILlRSGWPQEGTPLLDPMCGSGTLLIEAA 209
ThiI COG0301
Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) [Coenzyme ...
 228-282 3.63e-07

Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]; Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440070 [Multi-domain]  Cd Length: 382  Bit Score: 52.40  E-value: 3.63e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15215167 228 FRVTCNRAGEKHCFTSNEAARDFGGAIQEYFK-WKADMTNFDVEVLLNIHDNEVIV 282
Cdd:COG0301 103 FKVRAKRAGKHFPFTSPELEREVGGALLENTPgLKVDLKNPDVTIRVEVRDDKAYV 158
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 324-438 4.28e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 47.94  E-value: 4.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   324 IVDPMCGTGAIPIEGATEWSHCYhIAGDNNPLAVNRAANNISSLltksqikdgktswGLPIDAVQWDICNLPLRTASVDI 403
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARV-TGVDLSPEMLERARERAAEA-------------GLNVEFVQGDAEDLPFPDGSFDL 66

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15215167   404 IVTDMPFGkrmgskKRNWNLYPACLREMSRVCRPG 438
Cdd:pfam13649  67 VVSSGVLH------HLPDPDLEAALREIARVLKPG 95
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 312-445 2.75e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 45.53  E-value: 2.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167  312 MLRLCEPKPTDVIVDPMCGTGAIpiegATEWSHcyhiagdnnplAVNRAANNI-----SSLLTKSQIKDGKTSWGLPIDA 386
Cdd:PRK00216  43 TIKWLGVRPGDKVLDLACGTGDL----AIALAK-----------AVGKTGEVVgldfsEGMLAVGREKLRDLGLSGNVEF 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15215167  387 VQWDICNLPLRTASVDIiVTdMPFGKRmgskkrnwNL--YPACLREMSRVCRPGtGRAVLL 445
Cdd:PRK00216 108 VQGDAEALPFPDNSFDA-VT-IAFGLR--------NVpdIDKALREMYRVLKPG-GRLVIL 157
PRK08317 PRK08317
hypothetical protein; Provisional
 313-448 6.32e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 41.46  E-value: 6.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167  313 LRLCEPKPTDVIVDPMCGTGAIPIEGATEWSHCYHIAG-DNNP----LAVNRAANNisslltksqikdgktswGLPIDAV 387
Cdd:PRK08317  12 FELLAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGiDRSEamlaLAKERAAGL-----------------GPNVEFV 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15215167  388 QWDICNLPLRTASVDIIVTDmpfgkrmgskkrnwNLY------PACLREMSRVCRPGtGRAVLLTQD 448
Cdd:PRK08317  75 RGDADGLPFPDGSFDAVRSD--------------RVLqhledpARALAEIARVLRPG-GRVVVLDTD 126
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 329-444 5.21e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.49  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15215167   329 CGTGAIPIEGATEWSHCYHIagDNNPLAVNRAANNISslltksqikdgktswGLPIDAVQWDICNLPLRTASVDIIVTDM 408
Cdd:pfam08241   5 CGTGLLTELLARLGARVTGV--DISPEMLELAREKAP---------------REGLTFVVGDAEDLPFPDNSFDLVLSSE 67

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15215167   409 PFGkrmgskkrNWNLYPACLREMSRVCRPGtGRAVL 444
Cdd:pfam08241  68 VLH--------HVEDPERALREIARVLKPG-GILII 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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