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Conserved domains on  [gi|40225843|gb|AAH11870|]
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ZNF771 protein [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-221 1.77e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843  62 PHACPDCGRAFARRSTLAKHART--HTGE--RPFGCTE--CGRRFSQKSALTKHGRTHTGERPYECP--ECDKRFSAASN 133
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843 134 -----LRQHRRRHTGEKPYACAH--CGRRFAQSSNYAQHLRVHTGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYA 204
Cdd:COG5048 369 neppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                       170
                ....*....|....*..
gi 40225843 205 CADCGtRFAQSSALAKH 221
Cdd:COG5048 449 CSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.53e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 40225843   245 NLAEHARTHTGERPYPCAECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-240 3.36e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....
gi 40225843   217 ALAKHRRVHTGEKPHRCAVCGRRF 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-221 1.77e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843  62 PHACPDCGRAFARRSTLAKHART--HTGE--RPFGCTE--CGRRFSQKSALTKHGRTHTGERPYECP--ECDKRFSAASN 133
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843 134 -----LRQHRRRHTGEKPYACAH--CGRRFAQSSNYAQHLRVHTGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYA 204
Cdd:COG5048 369 neppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                       170
                ....*....|....*..
gi 40225843 205 CADCGtRFAQSSALAKH 221
Cdd:COG5048 449 CSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-158 1.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 40225843   133 NLRQHRRRHTGEKPYACAHCGRRFAQ 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 40225843   245 NLAEHARTHTGERPYPCAECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-240 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....
gi 40225843   217 ALAKHRRVHTGEKPHRCAVCGRRF 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-221 1.77e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843  62 PHACPDCGRAFARRSTLAKHART--HTGE--RPFGCTE--CGRRFSQKSALTKHGRTHTGERPYECP--ECDKRFSAASN 133
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843 134 -----LRQHRRRHTGEKPYACAH--CGRRFAQSSNYAQHLRVHTGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYA 204
Cdd:COG5048 369 neppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                       170
                ....*....|....*..
gi 40225843 205 CADCGtRFAQSSALAKH 221
Cdd:COG5048 449 CSILK-SFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 148-254 1.00e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 1.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843 148 ACAHCGRRFAQSSnyAQHLRVhTGEKPYACP--DCGRAFGGSSCLARHRRThtgerpyacADCGTRFAQSSALAKHRRVH 225
Cdd:COG5189 326 KLAHGGERNIDTP--SRMLKV-KDGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFS 393

                        90       100
                ....*....|....*....|....*....
gi 40225843 226 TGEKPHRCAVCGRRFGHRSNLAEHaRTHT 254
Cdd:COG5189 394 AKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 115-198 4.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 4.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843 115 GERPYECP--ECDKRFSAASNLRQHRRRhtgekpyacAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRAFGGSSCLAR 192
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 40225843 193 HrRTHT 198
Cdd:COG5189 417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
53-162 6.41e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 6.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843  53 PAPSADPaRPHACPDCGRAFARRSTLAKHARTHTGERPFGCTECGrrfsqksaltkhgrthtgerpyecpeCDKRFSAAS 132
Cdd:COG5048  25 KSLSNAP-RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPL 77

                        90       100       110
                ....*....|....*....|....*....|
gi 40225843 133 NLRQHRRRHTGEKPYACAHCGRRFAQSSNY 162
Cdd:COG5048  78 ELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-209 7.86e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 7.86e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40225843 145 KPYACAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRA--FGGSSCLARHRRTHTGERPYACADCG 209
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSL 98
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-158 1.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 40225843   133 NLRQHRRRHTGEKPYACAHCGRRFAQ 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
173-253 5.19e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40225843 173 KPYACPDCGRAFGGSSCLARHRRTHTGERPYACADCGTRFAQS--SALAKHRRVHTGEKPHRCA--VCGRRFGHRSNLAE 248
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLS 111


                ....*
gi 40225843 249 HARTH 253
Cdd:COG5048 112 SSSSN 116
zf-H2C2_2 pfam13465
Zinc-finger double domain;
105-129 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*
gi 40225843   105 ALTKHGRTHTGERPYECPECDKRFS 129
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-184 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....
gi 40225843   161 NYAQHLRVHTGEKPYACPDCGRAF 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 40225843   245 NLAEHARTHTGERPYPCAECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-240 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....
gi 40225843   217 ALAKHRRVHTGEKPHRCAVCGRRF 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 119-141 3.63e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 3.63e-03
                          10        20
                  ....*....|....*....|...
gi 40225843   119 YECPECDKRFSAASNLRQHRRRH 141
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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