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Conserved domains on  [gi|12667568|gb|AAG61188|]
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dissimilatory sulfite reductase subunit A, partial [uncultured sulfate-reducing bacterium UMTRAdsr608-25]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dsrA super family cl37041
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-118 6.95e-62

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


The actual alignment was detected with superfamily member TIGR02064:

Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 193.90  E-value: 6.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12667568     1 VIGRYSDSPEEFPEITAFHTMRVNQPTGWFYTTEALRKLCDIWDEHGSGLTNFHGSTGDIILLGTTTDHLQPCFDALSEA 80
Cdd:TIGR02064  64 VIGRYSDQGEKFPGVAEFHTVRVAQPSGKFYSTDYLRQLCDVWEKYGSGLTNFHGQTGDIVFLGTQTPQLQEIFEELTNL 143

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 12667568    81 GFDLGGSGSALRTPSACVGPARCEWACLDTL----DFVNDVT 118
Cdd:TIGR02064 144 GTDLGGSGSNLRTPESCVGPARCEFACYDTLkacyELTMEYQ 185
 
Name Accession Description Interval E-value
dsrA TIGR02064
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-118 6.95e-62

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 193.90  E-value: 6.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12667568     1 VIGRYSDSPEEFPEITAFHTMRVNQPTGWFYTTEALRKLCDIWDEHGSGLTNFHGSTGDIILLGTTTDHLQPCFDALSEA 80
Cdd:TIGR02064  64 VIGRYSDQGEKFPGVAEFHTVRVAQPSGKFYSTDYLRQLCDVWEKYGSGLTNFHGQTGDIVFLGTQTPQLQEIFEELTNL 143

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 12667568    81 GFDLGGSGSALRTPSACVGPARCEWACLDTL----DFVNDVT 118
Cdd:TIGR02064 144 GTDLGGSGSNLRTPESCVGPARCEFACYDTLkacyELTMEYQ 185
NIR_SIR_ferr pfam03460
Nitrite/Sulfite reductase ferredoxin-like half domain; Sulfite and Nitrite reductases are key ...
 19-80 1.46e-07

Nitrite/Sulfite reductase ferredoxin-like half domain; Sulfite and Nitrite reductases are key to both biosynthetic assimilation of sulfur and nitrogen and dissimilation of oxidized anions for energy transduction. Two copies of this repeat are found in Nitrite and Sulfite reductases and form a single structural domain.


Pssm-ID: 377044 [Multi-domain]  Cd Length: 67  Bit Score: 45.21  E-value: 1.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12667568    19 HTMRVNQPTGWFyTTEALRKLCDIWDEHGSG---LTnfhgSTGDIILLGTTTDHLQPCFDALSEA 80
Cdd:pfam03460   8 YMVRVRVPGGRL-TAEQLRALADIAEKYGDGeirLT----TRQNLELHGVPEEDLPELLEELAEA 67
CysI COG0155
Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; ...
 32-99 8.04e-03

Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Sulfite reductase, beta subunit (hemoprotein) is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439925 [Multi-domain]  Cd Length: 519  Bit Score: 34.71  E-value: 8.04e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12667568  32 TTEALRKLCDIWDEHGSG---LTNFHGstgdIILLGTTTDHLQPCFDALSEAGFDLGGSGsaLRTPS-ACVG 99
Cdd:COG0155 318 TDEQLRALADLAERYGSGeirLTPNQN----LILADVPEEDLPALEAALRALGLATPPSG--LRRDSiACPG 383
 
Name Accession Description Interval E-value
dsrA TIGR02064
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-118 6.95e-62

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 193.90  E-value: 6.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12667568     1 VIGRYSDSPEEFPEITAFHTMRVNQPTGWFYTTEALRKLCDIWDEHGSGLTNFHGSTGDIILLGTTTDHLQPCFDALSEA 80
Cdd:TIGR02064  64 VIGRYSDQGEKFPGVAEFHTVRVAQPSGKFYSTDYLRQLCDVWEKYGSGLTNFHGQTGDIVFLGTQTPQLQEIFEELTNL 143

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 12667568    81 GFDLGGSGSALRTPSACVGPARCEWACLDTL----DFVNDVT 118
Cdd:TIGR02064 144 GTDLGGSGSNLRTPESCVGPARCEFACYDTLkacyELTMEYQ 185
NIR_SIR_ferr pfam03460
Nitrite/Sulfite reductase ferredoxin-like half domain; Sulfite and Nitrite reductases are key ...
 19-80 1.46e-07

Nitrite/Sulfite reductase ferredoxin-like half domain; Sulfite and Nitrite reductases are key to both biosynthetic assimilation of sulfur and nitrogen and dissimilation of oxidized anions for energy transduction. Two copies of this repeat are found in Nitrite and Sulfite reductases and form a single structural domain.


Pssm-ID: 377044 [Multi-domain]  Cd Length: 67  Bit Score: 45.21  E-value: 1.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12667568    19 HTMRVNQPTGWFyTTEALRKLCDIWDEHGSG---LTnfhgSTGDIILLGTTTDHLQPCFDALSEA 80
Cdd:pfam03460   8 YMVRVRVPGGRL-TAEQLRALADIAEKYGDGeirLT----TRQNLELHGVPEEDLPELLEELAEA 67
NIR_SIR pfam01077
Nitrite and sulphite reductase 4Fe-4S domain; Sulphite and nitrite reductases are vital in the ...
 88-118 1.06e-03

Nitrite and sulphite reductase 4Fe-4S domain; Sulphite and nitrite reductases are vital in the biosynthetic assimilation of sulphur and nitrogen, respectfully. They are also both important for the dissimilation of oxidized anions for energy transduction.


Pssm-ID: 426031 [Multi-domain]  Cd Length: 153  Bit Score: 36.48  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 12667568    88 GSALRTPSACVGPARCEWACLDTLDFVNDVT 118
Cdd:pfam01077   1 GDNVRNVTLCPGAGLCPEELLDTRPLAKAIE 31
CysI COG0155
Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; ...
 32-99 8.04e-03

Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Sulfite reductase, beta subunit (hemoprotein) is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439925 [Multi-domain]  Cd Length: 519  Bit Score: 34.71  E-value: 8.04e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12667568  32 TTEALRKLCDIWDEHGSG---LTNFHGstgdIILLGTTTDHLQPCFDALSEAGFDLGGSGsaLRTPS-ACVG 99
Cdd:COG0155 318 TDEQLRALADLAERYGSGeirLTPNQN----LILADVPEEDLPALEAALRALGLATPPSG--LRRDSiACPG 383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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