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Conserved domains on  [gi|10998806|gb|AAG26001|]
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granule-bound starch synthase, partial [Ipomoea dichroa]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 1-140 7.31e-68

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03791:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 474  Bit Score: 212.04  E-value: 7.31e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   1 TQEWNPATDKYLGVKYDiSTVMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:cd03791 252 YDEWNPATDKLIPANYS-ANDLEGKAENKAALQKELGLPVDPDAPLFGFVGRLTEQKGVDLILDALPELLEEGGQLVVLG 330

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:cd03791 331 SGDPEYEQAFRELAERYPGKVAVVIGFDEALAHRIYAGADFFLMPSRFEPCGLVQMYAMR 390
 
Name Accession Description Interval E-value
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 1-140 7.31e-68

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 212.04  E-value: 7.31e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   1 TQEWNPATDKYLGVKYDiSTVMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:cd03791 252 YDEWNPATDKLIPANYS-ANDLEGKAENKAALQKELGLPVDPDAPLFGFVGRLTEQKGVDLILDALPELLEEGGQLVVLG 330

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:cd03791 331 SGDPEYEQAFRELAERYPGKVAVVIGFDEALAHRIYAGADFFLMPSRFEPCGLVQMYAMR 390
glgA TIGR02095
glycogen/starch synthase, ADP-glucose type; This family consists of glycogen (or starch) ...
 1-140 1.80e-64

glycogen/starch synthase, ADP-glucose type; This family consists of glycogen (or starch) synthases that use ADP-glucose (EC 2.4.1.21), rather than UDP-glucose (EC 2.4.1.11) as in animals, as the glucose donor. This enzyme is found in bacteria and plants. Whether the name given is glycogen synthase or starch synthase depends on context, and therefore on substrate. [Energy metabolism, Biosynthesis and degradation of polysaccharides]


Pssm-ID: 273969 [Multi-domain]  Cd Length: 473  Bit Score: 203.27  E-value: 1.80e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806     1 TQEWNPATDKYLGVKYDISTvMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:TIGR02095 249 TEVWNPATDPYLKANYSADD-LAGKAENKEALQEELGLPVDDDVPLFGVISRLTQQKGVDLLLAALPELLELGGQLVVLG 327

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:TIGR02095 328 TGDPELEEALRELAERYPGNVRVIIGYDEALAHLIYAGADFILMPSRFEPCGLTQLYAMR 387
GlgA COG0297
Glycogen synthase [Carbohydrate transport and metabolism];
1-140 2.90e-62

Glycogen synthase [Carbohydrate transport and metabolism];


Pssm-ID: 440066 [Multi-domain]  Cd Length: 476  Bit Score: 197.62  E-value: 2.90e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   1 TQEWNPATDKYLGVKYDISTvMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:COG0297 253 YDVWNPATDPYLPANYSADD-LEGKAANKAALQEELGLPVDPDAPLIGMVSRLTEQKGLDLLLEALDELLEEDVQLVVLG 331

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:COG0297 332 SGDPEYEEAFRELAARYPGRVAVYIGYDEALAHRIYAGADFFLMPSRFEPCGLNQMYALR 391
glgA PRK00654
glycogen synthase GlgA;
1-140 5.61e-55

glycogen synthase GlgA;


Pssm-ID: 234809 [Multi-domain]  Cd Length: 466  Bit Score: 178.39  E-value: 5.61e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    1 TQEWNPATDKYLGVKYDISTvMQAKPLLKEALQAAVGLPVDrDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:PRK00654 241 YDIWNPETDPLLAANYSADD-LEGKAENKRALQERFGLPDD-DAPLFAMVSRLTEQKGLDLVLEALPELLEQGGQLVLLG 318

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:PRK00654 319 TGDPELEEAFRALAARYPGKVGVQIGYDEALAHRIYAGADMFLMPSRFEPCGLTQLYALR 378
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
45-139 2.68e-07

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 46.74  E-value: 2.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    45 PLIGFIGRL-EEQKGSDILYAAIPKFIA--MNVQIVILGTGK-KKFEEQIEQLE--VMYPDKARGVAKFnvpLAHmitag 118
Cdd:pfam13692   2 PVILFVGRLhPNVKGVDYLLEAVPLLRKrdNDVRLVIVGDGPeEELEELAAGLEdrVIFTGFVEDLAEL---LAA----- 73

                          90       100
                  ....*....|....*....|.
gi 10998806   119 ADFMLIPSRFEPCGLIQLHAM 139
Cdd:pfam13692  74 ADVFVLPSLYEGFGLKLLEAM 94
 
Name Accession Description Interval E-value
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 1-140 7.31e-68

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 212.04  E-value: 7.31e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   1 TQEWNPATDKYLGVKYDiSTVMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:cd03791 252 YDEWNPATDKLIPANYS-ANDLEGKAENKAALQKELGLPVDPDAPLFGFVGRLTEQKGVDLILDALPELLEEGGQLVVLG 330

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:cd03791 331 SGDPEYEQAFRELAERYPGKVAVVIGFDEALAHRIYAGADFFLMPSRFEPCGLVQMYAMR 390
glgA TIGR02095
glycogen/starch synthase, ADP-glucose type; This family consists of glycogen (or starch) ...
 1-140 1.80e-64

glycogen/starch synthase, ADP-glucose type; This family consists of glycogen (or starch) synthases that use ADP-glucose (EC 2.4.1.21), rather than UDP-glucose (EC 2.4.1.11) as in animals, as the glucose donor. This enzyme is found in bacteria and plants. Whether the name given is glycogen synthase or starch synthase depends on context, and therefore on substrate. [Energy metabolism, Biosynthesis and degradation of polysaccharides]


Pssm-ID: 273969 [Multi-domain]  Cd Length: 473  Bit Score: 203.27  E-value: 1.80e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806     1 TQEWNPATDKYLGVKYDISTvMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:TIGR02095 249 TEVWNPATDPYLKANYSADD-LAGKAENKEALQEELGLPVDDDVPLFGVISRLTQQKGVDLLLAALPELLELGGQLVVLG 327

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:TIGR02095 328 TGDPELEEALRELAERYPGNVRVIIGYDEALAHLIYAGADFILMPSRFEPCGLTQLYAMR 387
GlgA COG0297
Glycogen synthase [Carbohydrate transport and metabolism];
1-140 2.90e-62

Glycogen synthase [Carbohydrate transport and metabolism];


Pssm-ID: 440066 [Multi-domain]  Cd Length: 476  Bit Score: 197.62  E-value: 2.90e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   1 TQEWNPATDKYLGVKYDISTvMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:COG0297 253 YDVWNPATDPYLPANYSADD-LEGKAANKAALQEELGLPVDPDAPLIGMVSRLTEQKGLDLLLEALDELLEEDVQLVVLG 331

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:COG0297 332 SGDPEYEEAFRELAARYPGRVAVYIGYDEALAHRIYAGADFFLMPSRFEPCGLNQMYALR 391
glgA PRK00654
glycogen synthase GlgA;
1-140 5.61e-55

glycogen synthase GlgA;


Pssm-ID: 234809 [Multi-domain]  Cd Length: 466  Bit Score: 178.39  E-value: 5.61e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    1 TQEWNPATDKYLGVKYDISTvMQAKPLLKEALQAAVGLPVDrDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:PRK00654 241 YDIWNPETDPLLAANYSADD-LEGKAENKRALQERFGLPDD-DAPLFAMVSRLTEQKGLDLVLEALPELLEQGGQLVLLG 318

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:PRK00654 319 TGDPELEEAFRALAARYPGKVGVQIGYDEALAHRIYAGADMFLMPSRFEPCGLTQLYALR 378
PRK14099 PRK14099
glycogen synthase GlgA;
1-140 2.50e-36

glycogen synthase GlgA;


Pssm-ID: 237610 [Multi-domain]  Cd Length: 485  Bit Score: 129.45  E-value: 2.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    1 TQEWNPATDKYLGVKYDISTvMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:PRK14099 253 TAVWNPATDELIAATYDVET-LAARAANKAALQARFGLDPDPDALLLGVISRLSWQKGLDLLLEALPTLLGEGAQLALLG 331

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:PRK14099 332 SGDAELEARFRAAAQAYPGQIGVVIGYDEALAHLIQAGADALLVPSRFEPCGLTQLCALR 391
PLN02316 PLN02316
synthase/transferase
 4-140 1.70e-32

synthase/transferase


Pssm-ID: 215180 [Multi-domain]  Cd Length: 1036  Bit Score: 120.36  E-value: 1.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806     4 WNPATDKYLGVKYDISTVMQAKPLLKEALQAAVGLPvDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILGTG- 82
Cdd:PLN02316  801 WDPYNDNFIPVPYTSENVVEGKRAAKEALQQRLGLK-QADLPLVGIITRLTHQKGIHLIKHAIWRTLERNGQVVLLGSAp 879

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10998806    83 ----KKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:PLN02316  880 dpriQNDFVNLANQLHSSHHDRARLCLTYDEPLSHLIYAGADFILVPSIFEPCGLTQLTAMR 941
PRK14098 PRK14098
starch synthase;
1-140 4.02e-32

starch synthase;


Pssm-ID: 172588 [Multi-domain]  Cd Length: 489  Bit Score: 118.30  E-value: 4.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    1 TQEWNPATDKYLGVKYDISTvMQAKPLLKEALQAAVGLPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILG 80
Cdd:PRK14098 265 TRQWNPSTDKLIKKRYSIER-LDGKLENKKALLEEVGLPFDEETPLVGVIINFDDFQGAELLAESLEKLVELDIQLVICG 343

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   81 TGKKKFEEQIEQLEVMYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:PRK14098 344 SGDKEYEKRFQDFAEEHPEQVSVQTEFTDAFFHLAIAGLDMLLMPGKIESCGMLQMFAMS 403
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1-140 5.22e-25

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 99.21  E-value: 5.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    1 TQEWNPATDKYLGVKYDiSTVMQAKPLLKEALQAAVGLP-VDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAMNVQIVIL 79
Cdd:PLN02939 736 TDTWNPSTDRFLKVQYN-ANDLQGKAANKAALRKQLGLSsADASQPLVGCITRLVPQKGVHLIRHAIYKTAELGGQFVLL 814

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10998806   80 GTG-----KKKFEEQIEQLEvmYPDKARGVAKFNVPLAHMITAGADFMLIPSRFEPCGLIQLHAMR 140
Cdd:PLN02939 815 GSSpvphiQREFEGIADQFQ--SNNNIRLILKYDEALSHSIYAASDMFIIPSMFEPCGLTQMIAMR 878
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 38-139 2.96e-11

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 59.47  E-value: 2.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  38 LPVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAM--NVQIVILGTGkkkfEEQIEQLEVMYPDKARGVaKF--NVPLAH 113
Cdd:cd03801 186 LGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRgpDVRLVIVGGD----GPLRAELEELELGLGDRV-RFlgFVPDEE 260

                        90       100
                ....*....|....*....|....*...
gi 10998806 114 M--ITAGADFMLIPSRFEPCGLIQLHAM 139
Cdd:cd03801 261 LpaLYAAADVFVLPSRYEGFGLVVLEAM 288
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
45-139 2.68e-07

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 46.74  E-value: 2.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    45 PLIGFIGRL-EEQKGSDILYAAIPKFIA--MNVQIVILGTGK-KKFEEQIEQLE--VMYPDKARGVAKFnvpLAHmitag 118
Cdd:pfam13692   2 PVILFVGRLhPNVKGVDYLLEAVPLLRKrdNDVRLVIVGDGPeEELEELAAGLEdrVIFTGFVEDLAEL---LAA----- 73

                          90       100
                  ....*....|....*....|.
gi 10998806   119 ADFMLIPSRFEPCGLIQLHAM 139
Cdd:pfam13692  74 ADVFVLPSLYEGFGLKLLEAM 94
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 30-139 1.20e-06

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 46.22  E-value: 1.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  30 EALQAAVGLPVDRdiPLIGFIGRLEEQKGSDILYAAIPKFIAMN--VQIVILGTG--KKKFEEQIEQLEVmypdkaRGVA 105
Cdd:cd03798 188 QPEDRGLGLPLDA--FVILFVGRLIPRKGIDLLLEAFARLAKARpdVVLLIVGDGplREALRALAEDLGL------GDRV 259

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 10998806 106 KFNVPL------AHMitAGADFMLIPSRFEPCGLIQLHAM 139
Cdd:cd03798 260 TFTGRLpheqvpAYY--RACDVFVLPSRHEGFGLVLLEAM 297
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 29-139 9.35e-06

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 43.77  E-value: 9.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  29 KEALQAAVGLPVDRDIPLigFIGRLEEQKGSDIL---YAAIPKFIAMNVQIVILGT---GKKKFEEQIEQLEVMYpdkaR 102
Cdd:cd03800 207 AEARRARLLLPPDKPVVL--ALGRLDPRKGIDTLvraFAQLPELRELANLVLVGGPsddPLSMDREELAELAEEL----G 280

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 10998806 103 GVAKFNVP-------LAHMITAgADFMLIPSRFEPCGLIQLHAM 139
Cdd:cd03800 281 LIDRVRFPgrvsrddLPELYRA-ADVFVVPSLYEPFGLTAIEAM 323
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 49-139 1.07e-05

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 43.16  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  49 FIGRLEEQKGSDILYAAIPKFIA--MNVQIVILGTGKKKFEEQIEQLEVMYPDKARGVAKF-NVPLAHMITAGADFMLIP 125
Cdd:cd01635 115 SVGRLVPEKGIDLLLEALALLKArlPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLvDDEVLELLLAAADVFVLP 194

                        90
                ....*....|....
gi 10998806 126 SRFEPCGLIQLHAM 139
Cdd:cd01635 195 SRSEGFGLVLLEAM 208
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 45-139 1.41e-05

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 42.26  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806    45 PLIGFIGRLEEQKGSDILYAAIPKFIAM--NVQIVILGTG--KKKFEEQIEQLEVmyPDKARgVAKF--NVPLAHMITAg 118
Cdd:pfam00534   3 KIILFVGRLEPEKGLDLLIKAFALLKEKnpNLKLVIAGDGeeEKRLKKLAEKLGL--GDNVI-FLGFvsDEDLPELLKI- 78

                          90       100
                  ....*....|....*....|.
gi 10998806   119 ADFMLIPSRFEPCGLIQLHAM 139
Cdd:pfam00534  79 ADVFVLPSRYEGFGIVLLEAM 99
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 41-139 1.82e-05

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 42.73  E-value: 1.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  41 DRDIPLIGFIGRLEEQKGSDILYAAIPKFIAM--NVQIVILGTG--KKKFEEQIEQLevmypdkarGVA--------KFN 108
Cdd:cd03811 185 PEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKypDVKLVILGDGplREELEKLAKEL---------GLAerviflgfQSN 255

                        90       100       110
                ....*....|....*....|....*....|.
gi 10998806 109 vPLAHMitAGADFMLIPSRFEPCGLIQLHAM 139
Cdd:cd03811 256 -PYPYL--KKADLFVLSSRYEGFPNVLLEAM 283
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 39-92 3.05e-04

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 39.14  E-value: 3.05e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 10998806  39 PVDRDIPLIGFIGRLEEQKGSDILYAAIPKFIAM--NVQIVILGTGKKK--FEEQIEQ 92
Cdd:cd03796 188 KPDPNKITIVVISRLVYRKGIDLLVGIIPRICKKhpNVRFIIGGDGPKRieLEEMREK 245
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 46-138 3.61e-04

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 39.19  E-value: 3.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  46 LIGFIGRLEEQKGSDILYAAIPKFIAM--NVQIVILGTG--KKKFEEQIEQLEVMypDKargvAKF-----NVP--LAHM 114
Cdd:cd03812 193 VLGHVGRFNEQKNHSFLIDIFEELKKKnpNVKLVLVGEGelKEKIKEKVKELGLE--DK----VIFlgfrnDVSeiLSAM 266

                        90       100
                ....*....|....*....|....
gi 10998806 115 itagaDFMLIPSRFEPCGLIQLHA 138
Cdd:cd03812 267 -----DVFLFPSLYEGLPLVAVEA 285
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 47-139 6.99e-04

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 38.08  E-value: 6.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  47 IGFIGRLEEQKGSDILYAAIPKFIAMNVQIVILGTGKkkfEEQIEQLEVMYPDKARGVAKFNVPLAHMitAGADFMLIPS 126
Cdd:cd03823 194 FGYIGRLTEEKGIDLLVEAFKRLPREDIELVIAGHGP---LSDERQIEGGRRIAFLGRVPTDDIKDFY--EKIDVLVVPS 268

                        90
                ....*....|....
gi 10998806 127 RF-EPCGLIQLHAM 139
Cdd:cd03823 269 IWpEPFGLVVREAI 282
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 45-139 9.05e-04

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 38.04  E-value: 9.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  45 PLIGFIGRLEEQKGSDILYAAIPKFIAMN-VQIVILGTGkkkfeEQIEQLEVMYPDkargV----AKFNVPLAHmITAGA 119
Cdd:cd03814 199 PLLLYVGRLAPEKNLEALLDADLPLAASPpVRLVVVGDG-----PARAELEARGPD----ViftgFLTGEELAR-AYASA 268

                        90       100
                ....*....|....*....|
gi 10998806 120 DFMLIPSRFEPCGLIQLHAM 139
Cdd:cd03814 269 DVFVFPSRTETFGLVVLEAM 288
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 43-139 4.25e-03

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 35.81  E-value: 4.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  43 DIPLIGFIGRLEEQKGSDILYAAIPKFIA--MNVQIVILGTGkkkfeeqiEQLevmYPDKARGVAKFNvpLAHMIT---- 116
Cdd:cd03821 203 DRRIILFLGRIHPKKGLDLLIRAARKLAEqgRDWHLVIAGPD--------DGA---YPAFLQLQSSLG--LGDRVTftgp 269

                        90       100       110
                ....*....|....*....|....*....|...
gi 10998806 117 ----------AGADFMLIPSRFEPCGLIQLHAM 139
Cdd:cd03821 270 lygeakwalyASADLFVLPSYSENFGNVVAEAL 302
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 43-139 5.04e-03

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 35.84  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806   43 DIPLIGFIGRLEEQKGSDILY---AAIPkfiamNVQIVILGTGKKKfeeqiEQLEVMYPDKargvakfNVPLAHMIT--- 116
Cdd:PLN02871 262 EKPLIVYVGRLGAEKNLDFLKrvmERLP-----GARLAFVGDGPYR-----EELEKMFAGT-------PTVFTGMLQgde 324

                         90       100
                 ....*....|....*....|....*...
gi 10998806  117 -----AGADFMLIPSRFEPCGLIQLHAM 139
Cdd:PLN02871 325 lsqayASGDVFVMPSESETLGFVVLEAM 352
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 40-139 5.33e-03

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 35.79  E-value: 5.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  40 VDRDIPLIGFIGRLEEQKGSDILYAAIPKF-IAMNVQIVILGTG--KKKFEEQIEQLevmypdKARGVAKF-----NVPL 111
Cdd:cd03819 178 LPEGKPVVGYVGRLSPEKGWLLLVDAAAELkDEPDFRLLVAGDGpeRDEIRRLVERL------GLRDRVTFtgfreDVPA 251

                        90       100
                ....*....|....*....|....*...
gi 10998806 112 AHmitAGADFMLIPSRFEPCGLIQLHAM 139
Cdd:cd03819 252 AL---AASDVVVLPSLHEEFGRVALEAM 276
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 45-139 5.84e-03

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 35.71  E-value: 5.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10998806  45 PLIGFIGRLEEQKGSDILYAAIPKfiaMNVQIVILGTG--KKKFEEQIEQLEVmypDKARGVAKF-NVPLAHMITAgADF 121
Cdd:cd03795 192 KIFLFIGRLVYYKGLDYLIEAAQY---LNYPIVIGGEGplKPDLEAQIELNLL---DNVKFLGRVdDEEKVIYLHL-CDV 264

                        90       100
                ....*....|....*....|
gi 10998806 122 MLIPS--RFEPCGLIQLHAM 139
Cdd:cd03795 265 FVFPSvlRSEAFGIVLLEAM 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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