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Conserved domains on  [gi|7021732|gb|AAF35413|]
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unknown protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
406-716 1.25e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.25e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  406 TQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVVEAEkkgellldrpellllatngspEPTTMSPRRRGRTSISrk 485
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK---------------------LLRTLTGHSGAVTSVA-- 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  486 slsleniFVPDSLF--------------GLSEKPFCSFQGHVDDVLDLAWS-KSQHLLSSSMDKTVRLWNLSSQTCLKVF 550
Cdd:COG2319 170 -------FSPDGKLlasgsddgtvrlwdLATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTL 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  551 S-HSDYVTCIQFNPvDDRYFISGSLDAKVRVWSIPDRQVVDWYDLHEM-VTSACYTPDGQGVLVGSYKGSCRMYSASDNK 628
Cdd:COG2319 243 TgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  629 LQQksqinlqnkKKKAHQKKITGFQFVPgSSSEVLVTSSDSRIRV--VDGTDLVNKLKGFRNTSSqiSASITADGKYVVS 706
Cdd:COG2319 322 LLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLAS 389

                       330
                ....*....|
gi 7021732  707 ASEDSHVYIW 716
Cdd:COG2319 390 GSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
406-716 1.25e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.25e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  406 TQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVVEAEkkgellldrpellllatngspEPTTMSPRRRGRTSISrk 485
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK---------------------LLRTLTGHSGAVTSVA-- 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  486 slsleniFVPDSLF--------------GLSEKPFCSFQGHVDDVLDLAWS-KSQHLLSSSMDKTVRLWNLSSQTCLKVF 550
Cdd:COG2319 170 -------FSPDGKLlasgsddgtvrlwdLATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTL 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  551 S-HSDYVTCIQFNPvDDRYFISGSLDAKVRVWSIPDRQVVDWYDLHEM-VTSACYTPDGQGVLVGSYKGSCRMYSASDNK 628
Cdd:COG2319 243 TgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  629 LQQksqinlqnkKKKAHQKKITGFQFVPgSSSEVLVTSSDSRIRV--VDGTDLVNKLKGFRNTSSqiSASITADGKYVVS 706
Cdd:COG2319 322 LLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLAS 389

                       330
                ....*....|
gi 7021732  707 ASEDSHVYIW 716
Cdd:COG2319 390 GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 406-717 5.55e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 5.55e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  406 TQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVVEAEKKgellldrpellllatngspepTTMSPRRRGRTSISrk 485
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL---------------------RTLKGHTGPVRDVA-- 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  486 slsleniFVPDSLFGLS--------------EKPFCSFQGHVDDVLDLAWSKSQHLLSSSM-DKTVRLWNLSSQTCLKVF 550
Cdd:cd00200  59 -------ASADGTYLASgssdktirlwdletGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTL 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  551 S-HSDYVTCIQFNPvDDRYFISGSLDAKVRVWSIPDRQVVDWYDLHEM-VTSACYTPDGQGVLVGSYKGSCRMYSASDNK 628
Cdd:cd00200 132 RgHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  629 LQQksqinlqnkKKKAHQKKITGFQFvpgSSSEVLVTSS--DSRIRV--VDGTDLVNKLKGfrNTSSQISASITADGKYV 704
Cdd:cd00200 211 CLG---------TLRGHENGVNSVAF---SPDGYLLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTSLAWSPDGKRL 276

                       330
                ....*....|...
gi 7021732  705 VSASEDSHVYIWK 717
Cdd:cd00200 277 ASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 407-440 1.80e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.80e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 7021732     407 QEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIW 440
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
406-440 1.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 7021732    406 TQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIW 440
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 505-587 7.70e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 7.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732   505 PFCSFQGHVDDVLDLAWSK--SQHLLSSSMDKTVRLWNL-----------SSQTCLKvfSHSDYVTCIQFNPVDdrYFI- 570
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIphndesvkeikDPQCILK--GHKKKISIIDWNPMN--YYIm 141

                         90
                 ....*....|....*...
gi 7021732   571 -SGSLDAKVRVWSIPDRQ 587
Cdd:PTZ00420 142 cSSGFDSFVNIWDIENEK 159
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
406-716 1.25e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.25e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  406 TQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVVEAEkkgellldrpellllatngspEPTTMSPRRRGRTSISrk 485
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK---------------------LLRTLTGHSGAVTSVA-- 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  486 slsleniFVPDSLF--------------GLSEKPFCSFQGHVDDVLDLAWS-KSQHLLSSSMDKTVRLWNLSSQTCLKVF 550
Cdd:COG2319 170 -------FSPDGKLlasgsddgtvrlwdLATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTL 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  551 S-HSDYVTCIQFNPvDDRYFISGSLDAKVRVWSIPDRQVVDWYDLHEM-VTSACYTPDGQGVLVGSYKGSCRMYSASDNK 628
Cdd:COG2319 243 TgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  629 LQQksqinlqnkKKKAHQKKITGFQFVPgSSSEVLVTSSDSRIRV--VDGTDLVNKLKGFRNTSSqiSASITADGKYVVS 706
Cdd:COG2319 322 LLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLAS 389

                       330
                ....*....|
gi 7021732  707 ASEDSHVYIW 716
Cdd:COG2319 390 GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 406-717 5.55e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 5.55e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  406 TQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVVEAEKKgellldrpellllatngspepTTMSPRRRGRTSISrk 485
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL---------------------RTLKGHTGPVRDVA-- 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  486 slsleniFVPDSLFGLS--------------EKPFCSFQGHVDDVLDLAWSKSQHLLSSSM-DKTVRLWNLSSQTCLKVF 550
Cdd:cd00200  59 -------ASADGTYLASgssdktirlwdletGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTL 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  551 S-HSDYVTCIQFNPvDDRYFISGSLDAKVRVWSIPDRQVVDWYDLHEM-VTSACYTPDGQGVLVGSYKGSCRMYSASDNK 628
Cdd:cd00200 132 RgHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  629 LQQksqinlqnkKKKAHQKKITGFQFvpgSSSEVLVTSS--DSRIRV--VDGTDLVNKLKGfrNTSSQISASITADGKYV 704
Cdd:cd00200 211 CLG---------TLRGHENGVNSVAF---SPDGYLLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTSLAWSPDGKRL 276

                       330
                ....*....|...
gi 7021732  705 VSASEDSHVYIWK 717
Cdd:cd00200 277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
410-722 1.11e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.11e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  410 QAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVveaekkgellldrpellllatngspepttmsprrrgrtsisrkslsl 489
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----------------------------------------------- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  490 enifvpdslfgLSEKPFCSFQGHVDDVLDLAWSK-SQHLLSSSMDKTVRLWNLSSQTCLKVFS-HSDYVTCIQFNPvDDR 567
Cdd:COG2319 108 -----------ATGLLLRTLTGHTGAVRSVAFSPdGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGK 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  568 YFISGSLDAKVRVWSIPDRQVVDWYDLHE-MVTSACYTPDGQGVLVGSYKGSCRMYSASDNKLQQksqinlqnkKKKAHQ 646
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---------TLTGHS 246

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7021732  647 KKITGFQFVPGSSSeVLVTSSDSRIRV--VDGTDLVNKLKGFRNTSSqiSASITADGKYVVSASEDSHVYIWKYESPA 722
Cdd:COG2319 247 GSVRSVAFSPDGRL-LASGSADGTVRLwdLATGELLRTLTGHSGGVN--SVAFSPDGKLLASGSDDGTVRLWDLATGK 321
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 405-673 4.15e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 4.15e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  405 KTQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVVEAEKKGellldrpellllatngspepttmsprrrgrtsisr 484
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT----------------------------------- 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  485 kslslenifvpdslfglsekpfcSFQGHVDDVLDLAWSKSQHLL-SSSMDKTVRLWNLSSQTCLKVFS-HSDYVTCIQFN 562
Cdd:cd00200 130 -----------------------TLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFS 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  563 PvDDRYFISGSLDAKVRVWSIPDRQVVDWYDLHEM-VTSACYTPDGQGVLVGSYKGSCRMYSASDNKLQQKsqinLQNkk 641
Cdd:cd00200 187 P-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT----LSG-- 259

                       250       260       270
                ....*....|....*....|....*....|..
gi 7021732  642 kkaHQKKITGFQFVPgSSSEVLVTSSDSRIRV 673
Cdd:cd00200 260 ---HTNSVTSLAWSP-DGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
407-585 2.38e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 2.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  407 QEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVveaekkgellldrpellllatngspepttmsprrrgrtsisrks 486
Cdd:COG2319 282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-------------------------------------------- 317

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  487 lslenifvpdslfgLSEKPFCSFQGHVDDVLDLAWS-KSQHLLSSSMDKTVRLWNLSSQTCLKVFS-HSDYVTCIQFNPv 564
Cdd:COG2319 318 --------------ATGKLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSP- 382

                       170       180
                ....*....|....*....|.
gi 7021732  565 DDRYFISGSLDAKVRVWSIPD 585
Cdd:COG2319 383 DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 509-720 8.72e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 8.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  509 FQGHVDDVLDLAWS-KSQHLLSSSMDKTVRLWNLSSQTCLKVFS-HSDYVTCIQFNPvDDRYFISGSLDAKVRVWSIPDR 586
Cdd:cd00200   5 LKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  587 QVVDWYDLHE-MVTSACYTPDGQGVLVGSYKGSCRMYSASDNKLQQ--------------------------KSQINLQN 639
Cdd:cd00200  84 ECVRTLTGHTsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTtlrghtdwvnsvafspdgtfvasssqDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  640 KKKKAHQKKITGFQ-------FVPgSSSEVLVTSSDSRIRVVD--GTDLVNKLKGFRNTSSQISASitADGKYVVSASED 710
Cdd:cd00200 164 LRTGKCVATLTGHTgevnsvaFSP-DGEKLLSSSSDGTIKLWDlsTGKCLGTLRGHENGVNSVAFS--PDGYLLASGSED 240

                       250
                ....*....|
gi 7021732  711 SHVYIWKYES 720
Cdd:cd00200 241 GTIRVWDLRT 250
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-582 1.16e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 1.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  399 ELTALYKTQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQVveaekkgellldrpellllatngspepttmsprrrg 478
Cdd:cd00200 163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL------------------------------------ 206

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732  479 rtsisrkslslenifvpdslfgLSEKPFCSFQGHVDDVLDLAWSKSQHLL-SSSMDKTVRLWNLSSQTCLKVFS-HSDYV 556
Cdd:cd00200 207 ----------------------STGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLRTGECVQTLSgHTNSV 264

                       170       180
                ....*....|....*....|....*.
gi 7021732  557 TCIQFNPvDDRYFISGSLDAKVRVWS 582
Cdd:cd00200 265 TSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 407-440 1.80e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.80e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 7021732     407 QEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIW 440
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
406-442 4.78e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 4.78e-06
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 7021732  406 TQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIWQV 442
Cdd:COG2319 365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 543-582 9.34e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 9.34e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 7021732     543 SQTCLKVFS-HSDYVTCIQFNPvDDRYFISGSLDAKVRVWS 582
Cdd:smart00320   1 SGELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
406-440 1.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 7021732    406 TQEIQAHNGSIWSIKFSLDGKYLASAGEDCIIHIW 440
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 502-540 1.54e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 7021732     502 SEKPFCSFQGHVDDVLDLAWSK-SQHLLSSSMDKTVRLWN 540
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
545-582 4.65e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7021732    545 TCLKVFS-HSDYVTCIQFNPvDDRYFISGSLDAKVRVWS 582
Cdd:pfam00400   2 KLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
504-540 7.16e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 7.16e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 7021732    504 KPFCSFQGHVDDVLDLAWSK-SQHLLSSSMDKTVRLWN 540
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPdGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 505-587 7.70e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 7.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7021732   505 PFCSFQGHVDDVLDLAWSK--SQHLLSSSMDKTVRLWNL-----------SSQTCLKvfSHSDYVTCIQFNPVDdrYFI- 570
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIphndesvkeikDPQCILK--GHKKKISIIDWNPMN--YYIm 141

                         90
                 ....*....|....*...
gi 7021732   571 -SGSLDAKVRVWSIPDRQ 587
Cdd:PTZ00420 142 cSSGFDSFVNIWDIENEK 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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