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Conserved domains on  [gi|4097431|gb|AAD00089|]
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phorbolin 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAD2 pfam18782
Novel AID APOBEC clade 2; A distnct family of AID/APOBEC deaminases found only in Amphibians.
 1-185 1.14e-92

Novel AID APOBEC clade 2; A distnct family of AID/APOBEC deaminases found only in Amphibians.


:

Pssm-ID: 436733 [Multi-domain]  Cd Length: 176  Bit Score: 267.70  E-value: 1.14e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431      1 MDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGWMVLmdQHMGFLCNEAKnllcgfygRHADWRFLDLVPSLQLDPAQI 80
Cdd:pfam18782   3 MYPRTFYFNFNNKPILYGRNKTYLCYEVERLDNGTWLP--QHRGFFRNQAK--------YHAELCFLSWFCGNQLPPYQN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     81 YRVTWFISWSPCFSwgCAGEVRAFLQENTHVRLPIFAARIY-DYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYR 159
Cdd:pfam18782  73 YQVTWYVSWSPCPE--CAGEVAEFLAEHPNVTLTIFAARLYyFWDPDYQEALRRLRQAGARVKIMDYEEFEYCWENFVYN 150

                         170       180
                  ....*....|....*....|....*.
gi 4097431    160 QGCPFQPWDGLEEHSQALSGRLRAIL 185
Cdd:pfam18782 151 QGEPFQPWDGLEENSRFLHRRLREIL 176
 
Name Accession Description Interval E-value
NAD2 pfam18782
Novel AID APOBEC clade 2; A distnct family of AID/APOBEC deaminases found only in Amphibians.
 1-185 1.14e-92

Novel AID APOBEC clade 2; A distnct family of AID/APOBEC deaminases found only in Amphibians.


Pssm-ID: 436733 [Multi-domain]  Cd Length: 176  Bit Score: 267.70  E-value: 1.14e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431      1 MDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGWMVLmdQHMGFLCNEAKnllcgfygRHADWRFLDLVPSLQLDPAQI 80
Cdd:pfam18782   3 MYPRTFYFNFNNKPILYGRNKTYLCYEVERLDNGTWLP--QHRGFFRNQAK--------YHAELCFLSWFCGNQLPPYQN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     81 YRVTWFISWSPCFSwgCAGEVRAFLQENTHVRLPIFAARIY-DYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYR 159
Cdd:pfam18782  73 YQVTWYVSWSPCPE--CAGEVAEFLAEHPNVTLTIFAARLYyFWDPDYQEALRRLRQAGARVKIMDYEEFEYCWENFVYN 150

                         170       180
                  ....*....|....*....|....*.
gi 4097431    160 QGCPFQPWDGLEEHSQALSGRLRAIL 185
Cdd:pfam18782 151 QGEPFQPWDGLEENSRFLHRRLREIL 176
 
Name Accession Description Interval E-value
NAD2 pfam18782
Novel AID APOBEC clade 2; A distnct family of AID/APOBEC deaminases found only in Amphibians.
 1-185 1.14e-92

Novel AID APOBEC clade 2; A distnct family of AID/APOBEC deaminases found only in Amphibians.


Pssm-ID: 436733 [Multi-domain]  Cd Length: 176  Bit Score: 267.70  E-value: 1.14e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431      1 MDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGWMVLmdQHMGFLCNEAKnllcgfygRHADWRFLDLVPSLQLDPAQI 80
Cdd:pfam18782   3 MYPRTFYFNFNNKPILYGRNKTYLCYEVERLDNGTWLP--QHRGFFRNQAK--------YHAELCFLSWFCGNQLPPYQN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     81 YRVTWFISWSPCFSwgCAGEVRAFLQENTHVRLPIFAARIY-DYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYR 159
Cdd:pfam18782  73 YQVTWYVSWSPCPE--CAGEVAEFLAEHPNVTLTIFAARLYyFWDPDYQEALRRLRQAGARVKIMDYEEFEYCWENFVYN 150

                         170       180
                  ....*....|....*....|....*.
gi 4097431    160 QGCPFQPWDGLEEHSQALSGRLRAIL 185
Cdd:pfam18782 151 QGEPFQPWDGLEENSRFLHRRLREIL 176
APOBEC2 pfam18772
APOBEC2; APOBEC2 is a highly conserved (slow-evolving) family of AID/APOBECs found in most ...
 1-186 8.70e-77

APOBEC2; APOBEC2 is a highly conserved (slow-evolving) family of AID/APOBECs found in most vertebrates including cartilaginous fishes. APOBEC2 is poorly understood in terms of their molecular functions and substrate specificity.


Pssm-ID: 465863 [Multi-domain]  Cd Length: 174  Bit Score: 227.48  E-value: 8.70e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431      1 MDPDTFTFNFNNDPLVLRRRQTYLCYEVERLdNGWMVLMDQhmGFLCNEAknllcgfyGRHADWRFLDLVPSLQLDPAQI 80
Cdd:pfam18772   1 MDPKTFKFQFKNVPYASGRNKTYLCYEVETR-SGSDLSPDR--GYLRNQA--------GCHAELCFLSWILPWQLDPGQK 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     81 YRVTWFISWSPCFSwgCAGEVRAFLQENTHVRLPIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYR 159
Cdd:pfam18772  70 YQVTWYVSWSPCPD--CARKLAEFLARHPNLSLTIFAARLYFFwEPEYQEGLRRLKRAGAQLKIMDYQDFEYCWENFVDN 147

                         170       180
                  ....*....|....*....|....*..
gi 4097431    160 QGCPFQPWDGLEEHSQALSGRLRAILQ 186
Cdd:pfam18772 148 QGRPFEPWEDLDENYEYLSRKLQEILR 174
NAD1 pfam18778
Novel AID APOBEC clade 1; A distinct family of AID/APOBEC-like deaminases found in ray-finned ...
 1-185 1.56e-72

Novel AID APOBEC clade 1; A distinct family of AID/APOBEC-like deaminases found in ray-finned fishes, the coelacanth, amphibians, lizards, and marsupials.


Pssm-ID: 465865 [Multi-domain]  Cd Length: 175  Bit Score: 216.76  E-value: 1.56e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431      1 MDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDngwmvLMDQHMGFLCNEAKnllcgfyGRHADWRFLDLVPSLQL-DPAQ 79
Cdd:pfam18778   3 MSPETFKFQFKNVEYASGRNKTLLCYEVKRGN-----SSSLWRGHLRNENS-------GCHAEICFLRWFSSWRLfDPSQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     80 IYRVTWFISWSPCFSwgCAGEVRAFLQENTHVRLPIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVY 158
Cdd:pfam18778  71 CYTITWYLSWSPCPS--CAAKLAEFLKAHPNVTLTIFAARLYYFeDPWNQEGLRSLASAGVTLSIMDYSDFEYCWENFVD 148

                         170       180
                  ....*....|....*....|....*..
gi 4097431    159 RQGCPFQPWDGLEEHSQALSGRLRAIL 185
Cdd:pfam18778 149 NEGRPFVPWEDLEENSRYYHRKLQRIL 175
APOBEC_N pfam08210
APOBEC-like N-terminal domain; A mechanism of generating protein diversity is mRNA editing. ...
 6-182 1.33e-61

APOBEC-like N-terminal domain; A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain. RNA editing by APOBEC-1 requires homodimerization and this complex interacts with RNA binding proteins to from the editosome (and references therein). This family also includes the functionally homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like role in the adaptive immune response of jawless vertebrates. Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and prokaryotes such as Wolbachia and Pseudomonas brassicacearum.


Pssm-ID: 462396 [Multi-domain]  Cd Length: 170  Bit Score: 188.73  E-value: 1.33e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431      6 FTFNFNNDPLVLRRRQTYLCYEVERLDNGwmvLMDQHMGFLCNEAKNllcgfyGRHADWRFLDLVPSLQLDPAQIYRVTW 85
Cdd:pfam08210   1 FFFHFKNLPYASGRHETYLCYEVKRDSGG---LVVEDKGYLRNQAAS------SLHAEERFLRWIHDLALDPGSNYEVTW 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     86 FISWSPCFSwgCAGEVRAFLQENTHVRLPIFAARIY-DYDPLY--KEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGC 162
Cdd:pfam08210  72 YVSWSPCNE--CASELAAFLSKHPNVRLRIFVSRLYyWEEPDYwnREGLRSLAQAGVQLRPMSYKDFEYCWNNFVDHDGE 149

                         170       180
                  ....*....|....*....|
gi 4097431    163 PFQPWDGLEEHSQALSGRLR 182
Cdd:pfam08210 150 PFKPWDGLHENSVYLARKLQ 169
SNAD4 pfam18750
Secreted Novel AID/APOBEC-like Deaminase 4; A family of secreted AID/APOBEC like deaminases ...
 51-155 2.27e-45

Secreted Novel AID/APOBEC-like Deaminase 4; A family of secreted AID/APOBEC like deaminases found only in sponges that often shows lineage-specific expansions.


Pssm-ID: 465854 [Multi-domain]  Cd Length: 116  Bit Score: 145.48  E-value: 2.27e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     51 KNLLCGFYGRHADWRFLDLVPSLQLDPAQIYRVTWFISWSPCFSwgCAGEVRAFLQENTHVRLPIFAARIYDYDPLYKEA 130
Cdd:pfam18750  14 RGYLSNEHEQHAEICFLENIRSRELDPSQRYRVTWYLSWSPCPE--CAQKIAEFLAEHPNVTLTIFAARLYHWDEDNRQG 91

                          90       100
                  ....*....|....*....|....*
gi 4097431    131 LQMLRDAGAQVSIMTYDEFEYCWDT 155
Cdd:pfam18750  92 LRSLAQAGVTLQIMTLEDFEYCWKN 116
APOBEC_C pfam05240
APOBEC-like C-terminal domain; This domain is found at the C-termini of the Apolipoprotein B ...
 110-185 2.33e-38

APOBEC-like C-terminal domain; This domain is found at the C-termini of the Apolipoprotein B mRNA editing enzyme.


Pssm-ID: 461599  Cd Length: 78  Bit Score: 126.44  E-value: 2.33e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4097431    110 HVRLPIFAARIYD-YDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAIL 185
Cdd:pfam05240   2 NVSLTIFAARLYYhWDPEYQQGLRRLVQAGAQVAIMSYKEFEYCWDNFVDNQGRPFQPWEGLEENSQLLSRRLQEIL 78
APOBEC3 pfam18771
APOBEC3; APOBEC3 deaminases act as restriction factors in the innate response to retroviruses ...
 19-165 1.20e-37

APOBEC3; APOBEC3 deaminases act as restriction factors in the innate response to retroviruses and various retroelements.


Pssm-ID: 465862 [Multi-domain]  Cd Length: 135  Bit Score: 126.83  E-value: 1.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     19 RRQTYLCYEVE-RLDNGWMvlmdqhMGFLCNEAKnllcgfygRHADWRFLDLVPSLQLDPAQIYRVTWFISWSPCFSwgC 97
Cdd:pfam18771   3 DRKAYLCYQLKgRNGSALD------RGYFSNKKK--------RHAEIRFIDKIRSLDLDNIQCYRITCYITWSPCPN--C 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4097431     98 AGEVRAFLQENTHVRLPIFAARIYDYD-PLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQ 165
Cdd:pfam18771  67 AAELVDFISLNPHLKLRIFASRLYYHWeRSYKEGLQKLQRAGVSVAVMTLPEFQDCWEDFVDHQEEPFR 135
APOBEC4_like pfam18774
APOBEC4-like -AID/APOBEC-deaminase; Cnidarian and Algal homologs of the APOBEC4-like AID ...
 83-157 8.21e-15

APOBEC4-like -AID/APOBEC-deaminase; Cnidarian and Algal homologs of the APOBEC4-like AID/APOBEC-like deaminases characterized by a distinct Zn chelating site involving residues from the conserved loops 1 and 3.


Pssm-ID: 408545 [Multi-domain]  Cd Length: 131  Bit Score: 67.59  E-value: 8.21e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4097431     83 VTWFISWSPCfsWGCAGEVRAFLQENTHVRLPIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFV 157
Cdd:pfam18774  56 ITWYLSWSPC--WECSGRILEFLSRHPNVTLGIYVARLFMHdDDRNRQGLRILQMNGVTIQVMMNKDYCYCWKAFK 129
APOBEC4 pfam18775
APOBEC4; A member of the AID/APOBEC family of cytosine deaminases. The biological function of ...
 83-157 7.28e-12

APOBEC4; A member of the AID/APOBEC family of cytosine deaminases. The biological function of APOBEC4 is poorly understood. However, it is widely conserved across vertebrates.


Pssm-ID: 436728  Cd Length: 74  Bit Score: 58.50  E-value: 7.28e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4097431     83 VTWFISWSPCfsWGCAGEVRAFLQENTHVRLPIFAARIYDYDPLY-KEALQMLRDAGAQVSIMTYDEFEYCWDTFV 157
Cdd:pfam18775   1 VTLYLSWSPC--NECSEKIQEFLKKHPKVNLDIYFAQLYHTEEEDnRQGLRSLVEKGVTLSVMSGEDWIYCLRTFV 74
APOBEC1 pfam18769
APOBEC1; APOBEC1 deaminates cytosine both in RNA and ssDNA and has roles in both mRNA editing ...
 60-144 1.25e-10

APOBEC1; APOBEC1 deaminates cytosine both in RNA and ssDNA and has roles in both mRNA editing and ssDNA mutagenesis as part of the defense against retroviruses and genomic retrotransposons.


Pssm-ID: 408540  Cd Length: 101  Bit Score: 55.97  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4097431     60 RHADWRFLD-LVPSLQLDPAQIYRVTWFISWSPCfsWGCAGEVRAFLQENTHVRLPIFAARIYDY-DPLYKEALQMLRDA 137
Cdd:pfam18769  17 QHAEVNFLEkFFSERHFDPSVSCSITWFLSWSPC--GECSKAIGEFLSQHPNVTLVIYAARLFKHlDIRNRQGLRDLAMS 94


                  ....*..
gi 4097431    138 GAQVSIM 144
Cdd:pfam18769  95 GVTIQIM 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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