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Conserved domains on  [gi|1857425|gb|AAC51139|]
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lysophosphatidic acid receptor homolog [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11607439)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
50-322 4.61e-173

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


:

Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 482.22  E-value: 4.61e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   50 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15344   1 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15344  81 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV 289
Cdd:cd15344 161 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV 240
                       250       260       270
                ....*....|....*....|....*....|...
gi 1857425  290 LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15344 241 LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
 
Name Accession Description Interval E-value
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
50-322 4.61e-173

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 482.22  E-value: 4.61e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   50 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15344   1 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15344  81 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV 289
Cdd:cd15344 161 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV 240
                       250       260       270
                ....*....|....*....|....*....|...
gi 1857425  290 LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15344 241 LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
67-311 3.26e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 123.95  E-value: 3.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425     67 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGpntrrLTVSTWLLRQGL-------IDTSLTASVANL 139
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYY-----LNHGDWPFGSALckivgalFVVNGYASILLL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425    140 LAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSV-GWNCICDIEN---CSNMAPLYSDSYLVFWAIFN 214
Cdd:pfam00001  77 TAISIDRYLAIVHpLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfGWTLTVPEGNvtvCFIDFPEDLSKPVSYTLLIS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425    215 LVTFV----VMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRdtmmsLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV- 289
Cdd:pfam00001 157 VLGFLlpllVILVCYTLIIRTLRKSASKQKSSERTQRRRK-----ALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELs 231
                         250       260
                  ....*....|....*....|....*.
gi 1857425    290 ----LAYEkFFLLLAEFNSAMNPIIY 311
Cdd:pfam00001 232 rlldKALS-VTLWLAYVNSCLNPIIY 256
 
Name Accession Description Interval E-value
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
50-322 4.61e-173

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 482.22  E-value: 4.61e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   50 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15344   1 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15344  81 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV 289
Cdd:cd15344 161 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV 240
                       250       260       270
                ....*....|....*....|....*....|...
gi 1857425  290 LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15344 241 LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
50-322 7.37e-164

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 458.90  E-value: 7.37e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   50 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15101   1 VLVMGLGITVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLAYFFLMFNTGPNTRRLTVSTWFLRQGLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15101  81 TSLTASVANLLAIAVERHISVMRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGWNCLCAIDACSNMAPLYSRSYLVF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP-QCD 288
Cdd:cd15101 161 WAISNLVTFLVMVVVYARIFVYVRRRTNRMSPHTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLCCrQCN 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 1857425  289 VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15101 241 VLAVEKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
50-322 7.38e-136

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 388.00  E-value: 7.38e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   50 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15342   1 YAVVALGLTVSVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLFLMFHTGPWTAKLSLYQWFLRQGLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15342  81 TSLTASVANLLAIAVERHQTIFTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGWNCLCDLKRCSTMAPLYSRSYLVF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLD-VCCPQCD 288
Cdd:cd15342 161 WALSNLLTFLIMVAVYTRIFIYVRRKSQRMSEHHSSHPRYRETVLGLMKTVVIILGAFVVCWTPGQVVLLLDgLGCESCN 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 1857425  289 VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15342 241 VLAYEKYFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
51-322 3.00e-107

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 315.28  E-value: 3.00e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDT 130
Cdd:cd15343   2 IVLCVGTFCCLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFW 210
Cdd:cd15343  82 SLSASLTNLLVIAVERHISIMRMKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGWNCICNISACSSLAPIYSRSYLVFW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  211 AIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLD-VCCPQCDV 289
Cdd:cd15343 162 SVSNLVVFLIMVVVYLRIYVYVQRKTNVLSPHTSGSINRRRTPIKLMKTVMTVLGAFVICWTPGLVVLLLDgLNCTRCGV 241
                       250       260       270
                ....*....|....*....|....*....|...
gi 1857425  290 LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15343 242 QHVKRWFLLLALLNSVMNPIIYSYKDEEMWGTM 274
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
52-322 1.04e-102

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 303.83  E-value: 1.04e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   52 VMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTS 131
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 LTASVANLLAIAIERHITVFRMQLH-TRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-CDIENCSNMAPLYSDSYLVF 209
Cdd:cd14972  81 LLASAYSLLAIAVDRYISIVHGLTYvNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVlCDQESCSPLGPGLPKSYLVL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS-RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP-QC 287
Cdd:cd14972 161 ILVFFFIALVIIVFLYVRIFWCLWRHANAIAaRQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPsVC 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 1857425  288 DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd14972 241 DIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
50-322 1.28e-70

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 221.96  E-value: 1.28e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   50 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15102   1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLREGSMF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15102  81 VALSASVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPILGWNCLGALDACSTVLPLYSKHYVLF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRnrdtmMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP--QC 287
Cdd:cd15102 161 CVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRS-----LALLKTVLIVLLVFIACWGPLFILLLLDVACPvkTC 235
                       250       260       270
                ....*....|....*....|....*....|....*
gi 1857425  288 DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15102 236 PILYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
57-322 2.28e-69

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 218.98  E-value: 2.28e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASV 136
Cdd:cd15346   8 IIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMFVALSASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  137 ANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLV 216
Cdd:cd15346  88 FSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  217 TFVVMVVLYAHIFGYVRQRTMRMS--RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP--QCDVLAY 292
Cdd:cd15346 168 LLLSIVILYCRIYSLVRTRSRRLTfrKNIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVGCKvkTCSILFK 247
                       250       260       270
                ....*....|....*....|....*....|
gi 1857425  293 EKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15346 248 AEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
57-322 3.33e-64

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 205.44  E-value: 3.33e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASV 136
Cdd:cd15345   8 LVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTQWFLREGSMFVALGAST 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  137 ANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLV 216
Cdd:cd15345  88 FSLLAIAIERHLTMIKMRPYDANKRYRVFLLIGTCWLISVLLGALPILGWNCLDNLPDCSTILPLYSKKYVAFCISIFIA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  217 TFVVMVVLYAHIFGYVRQRTMRMSRHssgprRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCC--PQCDVLAYEK 294
Cdd:cd15345 168 ILVAIVILYARIYILVKSSSRRVTNH-----RNSERSMALLRTVVIVVGVFIACWSPLFILLLIDVACevKQCPILYKAD 242
                       250       260
                ....*....|....*....|....*...
gi 1857425  295 FFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15345 243 WFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
57-318 3.88e-64

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 205.44  E-value: 3.88e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASV 136
Cdd:cd15348   8 LAVCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAAYAANILMSGANTLKLTPALWFLREGGVFITLTASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  137 ANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLV 216
Cdd:cd15348  88 FSLLAIAIERHITMVRMKPYPGDKRGRMFLLIGAAWLVSILLGVLPILGWNCLGNLDACSTVLPLYAKSYILFCITVFLA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  217 TFVVMVVLYAHIFGYVRQRTMRMS--RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP--QCDVLAY 292
Cdd:cd15348 168 ILAAIVVLYARIYRIVKANSQRLGalPTRKGRARRSQKYLALLKTVTIVLGTFVACWLPLFLLLLLDVSCPaqACPVLLK 247
                       250       260
                ....*....|....*....|....*.
gi 1857425  293 EKFFLLLAEFNSAMNPIIYSYRDKEM 318
Cdd:cd15348 248 ADYFLGLAMINSLLNPIIYTLTSRDM 273
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
57-322 2.88e-58

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 190.02  E-value: 2.88e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASV 136
Cdd:cd15347   8 VILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLSGSVTFRLTPVQWFIREGTAFITLSASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  137 ANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLV 216
Cdd:cd15347  88 FSLLAIAIERHVAITKVKLYGSDKNCRMVLLIGACWVISIVLGGLPILGWNCIGNLEDCSTVLPLYSKHYILFVVTIFSI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  217 TFVVMVVLYAHIFGYVRQRTMRMSRHSSgprrnrdtmMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP--QCDVLAYEK 294
Cdd:cd15347 168 ILLSIVILYVRIYCIVRSSHAEMAAPQT---------LALLKTVTIVLGVFIVCWLPAFIILLLDTSCKvkSCPILYKAD 238
                       250       260
                ....*....|....*....|....*...
gi 1857425  295 FFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15347 239 YFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
51-318 1.65e-55

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 183.06  E-value: 1.65e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDT 130
Cdd:cd15349   2 ALTVLFICISVLIILENLLVLLAILRRVRLRRWVYICLANIALSDLLTGTSYLVNICLSGERTFRLTPALWFLREGLLFT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15349  82 ALAASTFSLLVTAVERYATMVRpVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGWNCLCDFRSCSSLLPLYSKSYILF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRhssgpRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCC--PQC 287
Cdd:cd15349 162 CLVIFFIILLTIIGLYFAIYCLVRASGQRVIS-----ARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCssRSC 236
                       250       260       270
                ....*....|....*....|....*....|.
gi 1857425  288 DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEM 318
Cdd:cd15349 237 KPLFGMEWVLALAVLNSAINPLIYSFRSLEV 267
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
57-314 5.78e-37

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 134.34  E-value: 5.78e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYF-YLMFNTGPNTRRLTVSTWLLRQGLIDTSLTAS 135
Cdd:cd00637   6 ILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIpFSLVSLLLGRWWFGDALCKLLGFLQSVSLLAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  136 VANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFN 214
Cdd:cd00637  86 ILTLTAISVDRYLAIVHpLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAYTIFL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  215 LVT-----FVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMS--LLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC 287
Cdd:cd00637 166 FVLlfllpLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRErkVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDP 245
                       250       260
                ....*....|....*....|....*....
gi 1857425  288 DVLAYE--KFFLLLAEFNSAMNPIIYSYR 314
Cdd:cd00637 246 SPLPRIlyFLALLLAYLNSAINPIIYAFF 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
51-322 3.03e-34

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 126.91  E-value: 3.03e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY--FYLMFntgpntrrLTVSTWLLRQGL- 127
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVmpFSAVY--------TLLGYWPFGPVLc 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 -----IDTSL-TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMA- 199
Cdd:cd14967  73 rfwiaLDVLCcTASILNLCAISLDRYLAITRpLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECe 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSDSYLVFWAIFNLVT-FVVMVVLYAHIFgYVRQRTMRMsrhssgprrnrdtmmslLKTVVIVLGAFIICWTPGLVLL 278
Cdd:cd14967 153 FTPNKIYVLVSSVISFFIpLLIMIVLYARIF-RVARRELKA-----------------AKTLAIIVGAFLLCWLPFFIIY 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 1857425  279 LLDVCCPQCDV-LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd14967 215 LVSAFCPPDCVpPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
67-311 3.26e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 123.95  E-value: 3.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425     67 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGpntrrLTVSTWLLRQGL-------IDTSLTASVANL 139
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYY-----LNHGDWPFGSALckivgalFVVNGYASILLL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425    140 LAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSV-GWNCICDIEN---CSNMAPLYSDSYLVFWAIFN 214
Cdd:pfam00001  77 TAISIDRYLAIVHpLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfGWTLTVPEGNvtvCFIDFPEDLSKPVSYTLLIS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425    215 LVTFV----VMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRdtmmsLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV- 289
Cdd:pfam00001 157 VLGFLlpllVILVCYTLIIRTLRKSASKQKSSERTQRRRK-----ALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELs 231
                         250       260
                  ....*....|....*....|....*.
gi 1857425    290 ----LAYEkFFLLLAEFNSAMNPIIY 311
Cdd:pfam00001 232 rlldKALS-VTLWLAYVNSCLNPIIY 256
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
52-322 2.14e-28

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 111.92  E-value: 2.14e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   52 VMGLGITVCIFIMLANLLVMVAIYVNRRFHF-PIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDT 130
Cdd:cd15340   3 IAVLSLTLGTFTVLENLLVLCVILHSRSLRCrPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHRKDSPNVFLFKLGGVTA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITVFRMQLHTRMSNR-RVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15340  83 SFTASVGSLFLTAIDRYISIHRPLAYKRIVTRtKAVIAFCVMWTIAIVIAVLPLLGWNCKKLNSVCSDIFPLIDETYLMF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPR--------------RNRDTMMS--LLKTVVIVLGAFIICWTP 273
Cdd:cd15340 163 WIGVTSVLLLFIVYAYMYILWKAHHHAVRMLQRGTQKSiivytsedgkvqttRPDQTRMDirLAKTLVLILVVLIICWGP 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 1857425  274 GLVLLLLDVCCPQCDVL-AYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15340 243 LLAIMVYDVFGKMNKLIkTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-322 2.33e-28

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 111.85  E-value: 2.33e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   50 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHF-PIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLI 128
Cdd:cd15099   1 KAIAVLCFLAGPVTFLENILVLLTILSSTALRRrPSYLFIGSLALADMLASVIFTISFLDFHVFHQRDSRNLFLFKLGGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DTSLTASVANLLAIAIERHITVFRMQLHTRMSNR-RVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYL 207
Cdd:cd15099  81 TMAFTASVGSLLLTALDRYLCIYQPSNYKLLVTRtRAKVAILLMWCVTIIISFLPLMGWRCKTWDSPCSRLFPYIDRHYL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  208 VFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSG----PRRNRDTM-MSLLKTVVIVLGAFIICWTPGLVLLLLDV 282
Cdd:cd15099 161 ASWTGLQLVLLFLIIYAYPYILWKAHRHEANMGGPKLGrqqvKGQARMRMdIRLAKTLSLILLVLAICWLPVLAFMLVDV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 1857425  283 CCPQCD-VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15099 241 RVTLTNkQKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
53-322 4.28e-28

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 111.19  E-value: 4.28e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   53 MGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY--FYLMFNTGPNTRR---LTVSTWLlrqgL 127
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAipLAILISLGLPTNFhgcLFMACLV----L 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 IDTslTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN---CICDIENCSNMAPLY- 202
Cdd:cd14968  80 VLT--QSSIFSLLAIAIDRYLAIKiPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNngaPLESGCGEGGIQCLFe 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  203 ---SDSYLVFWAIFN--LVTFVVMVVLYAHIFgYVRQRTMRMSRHSSGPRRNRDTM---MSLLKTVVIVLGAFIICWTPG 274
Cdd:cd14968 158 eviPMDYMVYFNFFAcvLVPLLIMLVIYLRIF-RVIRKQLRQIESLLRSRRSRSTLqkeVKAAKSLAIILFLFALCWLPL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 1857425  275 LVLLLLDVCCPQCDVLayEKFFL---LLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd14968 237 HIINCITLFCPECKVP--KILTYiaiLLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
57-318 4.02e-25

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 102.65  E-value: 4.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCI---FIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA---YFYLMFNTGpntrrlTVSTWLLRQGLIDT 130
Cdd:cd15963   5 VVLCIsgtVISCENAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLGlilHFAFVYCIQ------SAPVNLVTVGLLAP 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd15963  79 SFTASVSSLLAITIDRYLSLYNaLTYYSERTVTRTYIMLILTWGASLCLGLLPVVGWNCLKDPSTCSVVKPLTKNHLVIL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVtFVVMVVLYAHIFGYVRQRTMRMS--RHSSgPRRNRDTMMSLLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQ 286
Cdd:cd15963 159 SISFFMV-FALMLQLYAQICRIVCRHAHQIAlqRHFL-PTSHYVTTRKGIATLAVILGTFASCWLPfAVYCLLGDYTYPA 236
                       250       260       270
                ....*....|....*....|....*....|..
gi 1857425  287 CdvlaYEKFFLLLAEFNSAMNPIIYSYRDKEM 318
Cdd:cd15963 237 L----YTYATLLPATYNSMINPIIYAFRNQEI 264
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-318 1.22e-24

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 101.45  E-value: 1.22e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   47 TVSKLVMGLGItVCIfimLANLLVMVAIYVNRRFHF-PIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQ 125
Cdd:cd15341   2 AIAVLCTLCGL-LCI---LENVAVLYLILSSPKLRRkPSYLFIGSLALADFLASVVFACSFVDFHVFHGVDSSAIFLLKL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  126 GLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNR-RVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSD 204
Cdd:cd15341  78 GGVTMSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRkRALVALAVMWVLTALIAYLPLMGWNCCPLNSPCSELFPLIPN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  205 SYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHS--SGPRRNRDTM-MSLLKTVVIVLGAFIICWTPGLVLLLLD 281
Cdd:cd15341 158 DYLLSWLLLVAILLSGIIYTYGHVLWKAHKHVVYMEKHQdqQGPGNARMRLdVRLAKTLGLVLAVLLICWSPVLALMMHS 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 1857425  282 VCCPQCD-VLAYEKFFLLLAEFNSAMNPIIYSYRDKEM 318
Cdd:cd15341 238 LFTSLSDhIKKAFAFCSTLCLVNSMVNPIIYALRSREL 275
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
57-318 1.31e-24

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 101.01  E-value: 1.31e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCI---FIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA---YFYLMFNTGPNTrrltvsTWLLRQGLIDT 130
Cdd:cd15100   5 IVLCVsgtLIACENAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGlilHFVFRYCVYSEA------LSLVSVGLLVA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLySDSYLVF 209
Cdd:cd15100  79 AFSASVCSLLAITVDRYLSLYNaLTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNCLREGSSCSVVRPL-TKNHLAV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS-RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPglvLLLLDVCCPQCD 288
Cdd:cd15100 158 LAVAFLLVFALMLQLYAQICRIVLRHAHQIAlQRHFLAPSHYVATRKGVSTLALILGTFAACWIP---FAVYCLLGDGSS 234
                       250       260       270
                ....*....|....*....|....*....|
gi 1857425  289 VLAYEKFFLLLAEFNSAMNPIIYSYRDKEM 318
Cdd:cd15100 235 PALYTYATLLPATYNSMINPIIYAFRNQDI 264
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
57-322 3.91e-24

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 99.98  E-value: 3.91e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA------YFYLMFNTGPNTRRLTVSTWLLRQGLIDT 130
Cdd:cd15353   8 VTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSngsetvVITLLNGNDTDAQSFTVNIDNVIDSVICS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVgwncicdiencsnmaplYSDSYLVF 209
Cdd:cd15353  88 SLLASICSLLSIAVDRYFTIFyALQYHNIMTVRRAGVIITCIWTACTVSGVLFII-----------------YSDSSVVI 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLV--TFVVMVVLYAHIFGYVRQRTMRMS-RHSSGPRRNRDTMMSLLkTVVIVLGAFIICWTPGLVLLLLDVCCPQ 286
Cdd:cd15353 151 ICLISMFftMLALMASLYVHMFLLARLHIKRIAvLPGTGPIRQGANMKGAI-TLTILLGVFVVCWAPFFLHLIFYISCPR 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 1857425  287 CD----VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15353 230 NPycvcFMSHFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
62-322 4.46e-24

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 99.72  E-value: 4.46e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   62 FIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAyfyLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLA 141
Cdd:cd15961  13 LISCENAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIG---LILNFIFAYLLQSEAAKLVTVGLIVASFSASVCSLLA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  142 IAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFnLVTFVV 220
Cdd:cd15961  90 ITVDRYLSLYyALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADESTCSVVRPLTKNNAAILSVSF-LLMFAL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  221 MVVLYAHIFGYVRQRTMRMS-RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQCdvlaYEKFFLL 298
Cdd:cd15961 169 MLQLYIQICKIVMRHAHQIAlQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPfTLYSLIADYTYPSI----YTYATLL 244
                       250       260
                ....*....|....*....|....
gi 1857425  299 LAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15961 245 PATYNSIINPVIYAFRNQEIQKAL 268
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
61-322 2.19e-23

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 98.21  E-value: 2.19e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIMLANLLVMVAIYVNRRFHF-PIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTW-LLRQGLIDTSLTASVAN 138
Cdd:cd15104  11 PLIITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLcLLRMCFVITSCAASVLS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  139 LLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP--SVGWNCICDIENCSNMAPLYSDSYLVFWAIFNL 215
Cdd:cd15104  91 LAAIAFDRYLALKQpLRYKQIMTGKSAGALIAGLWLYSGLIGFLPliSPQFQQTSYKGKCSFFAAFHPRVLLVLSCMVFF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  216 VTFVVMVVLYAHIF----GYVRQ-RTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC--- 287
Cdd:cd15104 171 PALLLFVFCYCDILkiarVHSRAiYKVEHALARQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITGLVQALCDECkly 250
                       250       260       270
                ....*....|....*....|....*....|....*
gi 1857425  288 DVLayEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15104 251 DVL--EDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
57-322 4.88e-23

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 96.93  E-value: 4.88e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA------YFYLMfntgpNTRRLTVSTWLLRQ----- 125
Cdd:cd15354   8 LTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSnawetiTIYLL-----NNRHLVIEDAFVRHidnvf 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  126 -GLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIvmgaipsvgwncicdieNCSNMAPLYS 203
Cdd:cd15354  83 dSLICISVVASMCSLLAIAVDRYVTIFyALRYHNIMTVRRAGIIIACIWTFCT-----------------GCGIIFILYS 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  204 DSYLVFWAIFNL--VTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLD 281
Cdd:cd15354 146 ESTYVIICLITMffAMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMKGAVTLTILLGIFIVCWAPFFLHLILM 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 1857425  282 VCCPQ----CDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15354 226 ISCPQnlycVCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-322 6.44e-23

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 96.40  E-value: 6.44e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   54 GLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA-----YFYLMFNTGPNTRRLTVSTWL--LRQG 126
Cdd:cd15103   5 EVFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSnaletIVIILLNNGYLVPRDSFEQHIdnVIDS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 LIDTSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVmgaipsvgwncicdienCSNMAPLYSDS 205
Cdd:cd15103  85 MICSSLLASICSLLAIAVDRYITIFYaLRYHSIMTVRRAGVIITAIWVFCTV-----------------CGILFIIYSDS 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  206 YLVfwaIFNLVTF-----VVMVVLYAHIFGYVRQRTMRMSR-HSSGPRRNRDTMMSLLkTVVIVLGAFIICWTPGLVLLL 279
Cdd:cd15103 148 VPV---IICLISMffamlVLMASLYVHMFLLARSHVKKIAAlPGQRSTRQRANMKGAV-TLTILLGVFIFCWAPFFLHLT 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 1857425  280 LDVCCPQ---CD-VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15103 224 LMISCPSnpyCAcYMSHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
54-321 1.88e-22

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 95.24  E-value: 1.88e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   54 GLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA-----YFYLMFNTGPntrrLTVSTWLLRQ--G 126
Cdd:cd15351   5 GLFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSnlietLFMLLLEHGV----LVCRAPMLQHmdN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 LIDT----SLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVmgaipsvgwncicdienCSNMAPL 201
Cdd:cd15351  81 VIDTmicsSVVSSLSFLGAIAVDRYITIFyALRYHSIMTLQRAVNAIAGIWLASTV-----------------SSTLFIV 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  202 YSDSYLVFWAI--FNLVTFVVMVVLYAHIFGYVRQRTMRMSR-HSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLL 278
Cdd:cd15351 144 YYNSNAVILCLivFFLFMLVLMLVLYIHMFILACRHSQSISSqQRRQCPHQQTASLKGAITLTILLGIFFLCWGPFFLHL 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 1857425  279 LLDVCCPQ---CD-VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSAT 321
Cdd:cd15351 224 TLIVTCPThpfCLcYFKYFNLFLILIICNSIIDPLIYAFRSQELRKT 270
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
51-322 7.87e-22

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 93.16  E-value: 7.87e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVcIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTWLLRQGLID- 129
Cdd:cd15064   3 ISVLLSLII-LATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPL------SAVYELTGRWILGQVLCDi 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 ------TSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW--NCICDIENCS-NMA 199
Cdd:cd15064  76 wisldvTCCTASILHLCVIALDRYWAITDaVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWrtPDSEDPSECLiSQD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSdSYLVFWAIFnlVTFVVMVVLYAHIFgyvrqrtmrmsrhSSGPRRNRDTmmsllKTVVIVLGAFIICWTPGLVLLL 279
Cdd:cd15064 156 IGYT-IFSTFGAFY--IPLLLMLILYWKIY-------------RAAARERKAA-----KTLGIILGAFIVCWLPFFLVAL 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 1857425  280 LDVCCPQCDV-LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15064 215 IVPLCSHCWIpLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
57-318 3.95e-21

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 91.53  E-value: 3.95e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCI---FIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAyFYLMFNTGPNTRRLTVStwLLRQGLIDTSLT 133
Cdd:cd15962   5 IMLCIsgtVIACENAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCG-LILNFVFQYVIQSETIS--LITVGFLVASFT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAI 212
Cdd:cd15962  82 ASVSSLLAITVDRYLSLYNaLTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGWNCLEERASCSIVRPLTKSNVTLLSAS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  213 FNLVtFVVMVVLYAHIFGYV--RQRTMRMSRHSSGPRRNRDTMMSlLKTVVIVLGAFIICWTPglvLLLLDVCCPQCDVL 290
Cdd:cd15962 162 FFFI-FILMLHLYIKICKIVcrHAHQIALQQHFLTASHYVATKKG-VSTLAIILGTFGASWLP---FAIYCVVGDHEYPA 236
                       250       260
                ....*....|....*....|....*...
gi 1857425  291 AYEKFFLLLAEFNSAMNPIIYSYRDKEM 318
Cdd:cd15962 237 VYTYATLLPATYNSMINPIIYAYRNQEI 264
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
52-322 6.14e-21

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 91.64  E-value: 6.14e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   52 VMGLGITVCIFIMLA-NLLVMVAIYVNRRFHFPIYYLMANLAAADFF-AGLAYFYLMFNT--GPntrrltvstWLLRQGL 127
Cdd:cd15065   1 LIGIFLSLIIVLAIFgNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLvALLVMTFAVVNDllGY---------WLFGETF 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 IDTSL-------TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP-SVGW-----NCICDIE 193
Cdd:cd15065  72 CNIWIsfdvmcsTASILNLCAISLDRYIHIKKpLKYERWMTTRRALVVIASVWILSALISFLPiHLGWhrlsqDEIKGLN 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  194 NCSNMAPL-YSDSYLVFWAIFNLVTF----VVMVVLYAHIFGYVRQR------------TMRMSRHSSGPRRNRDTMMSL 256
Cdd:cd15065 152 HASNPKPScALDLNPTYAVVSSLISFyipcLVMLLIYSRLYLYARKHvvniksqklpseSGSKFQVPSLSSKHNNQGVSD 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1857425  257 LK---TVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15065 232 HKaavTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
57-322 7.01e-21

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 91.10  E-value: 7.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA-YFYLMFNTGPNTRRLTVSTWLLRQ------GLID 129
Cdd:cd15352   8 LTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSnSLETIMIAVLNSGYLVISDQFIQHmdnvfdSMIC 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVgwncicdiencsnmaplYSDSYLV 208
Cdd:cd15352  88 ISLVASICNLLAIAVDRYVTIFyALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIV-----------------YSESKTV 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  209 FWAIFNL--VTFVVMVVLYAHIFGYVRQRTMRMSR--HSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCC 284
Cdd:cd15352 151 IVCLITMffAMLVLMATLYVHMFLFARLHVKRIAAlpPAVDGAPQQRSCMKGAVTITILLGVFIVCWAPFFLHLILIISC 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 1857425  285 PQ----CDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15352 231 PHnpycLCYTSHFNTYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
55-324 2.28e-20

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 89.70  E-value: 2.28e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIML---ANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayFYLMFNT----------GPNTRRLTVStw 121
Cdd:cd15051   3 LGVVLAVIILLtviGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGL--LVLPFSAiyelrgewplGPVFCNIYIS-- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  122 llrqglIDTSL-TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP-SVGWNC-------ICD 191
Cdd:cd15051  79 ------LDVMLcTASILNLFAISLDRYLAITApLRYPSRVTPRRVAIALAAIWVVSLAVSFLPiHLGWNTpdgrvqnGDT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  192 IENCS-NMAPLYS--DSYLVFWaifnlVTFVVMVVLYAHIFGYVRQRTMRMSR-HSSGPRRNRDTMMSL-----LKTVVI 262
Cdd:cd15051 153 PNQCRfELNPPYVllVAIGTFY-----LPLLIMCGVYLRIFRIAREQAKRINAlTPASTANSSKSAATArehkaTVTLAA 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1857425  263 VLGAFIICWTPGLVL-LLLDVCCPQCDVLAYEkFFLLLAEFNSAMNPIIYSYRDKEmsatFRQ 324
Cdd:cd15051 228 VLGAFIICWFPYFTYfTYRGLCGDNINETALS-VVLWLGYANSALNPILYAFLNRD----FRR 285
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
51-322 2.73e-20

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 89.61  E-value: 2.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY--FYLMFNTGPNTrrlTVSTWLLRQGLI 128
Cdd:cd15068   2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAipFAITISTGFCA---ACHGCLFIACFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DTSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN-CICDIENCSN--------M 198
Cdd:cd15068  79 LVLTQSSIFSLLAIAIDRYIAIrIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNnCGQPKEGKNHsqgcgegqV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  199 APLYSD----SYLVFWAIFN--LVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLL---KTVVIVLGAFII 269
Cdd:cd15068 159 ACLFEDvvpmNYMVYFNFFAcvLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVhaaKSLAIIVGLFAL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 1857425  270 CWTPGLVLLLLDVCCPQCDVLAYEKFFL--LLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15068 239 CWLPLHIINCFTFFCPDCSHAPLWLMYLaiVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
67-318 1.46e-19

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 87.26  E-value: 1.46e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   67 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY-----FYLMFNTGPNTrrltvstwLLRQGLIDTSLTASVANLLA 141
Cdd:cd15960  18 NAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLianfvAIYVMNSEAVT--------LCSAGLLLAAFSASVCSLLA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  142 IAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFwAIFNLVTFVV 220
Cdd:cd15960  90 ITVDRYLSLYNaLTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGWNCLRAPASCSVLRPVTKNNAAVL-AVSFLLLFAL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  221 MVVLYAHI----FGYVR----QRTMRMSRHSSGPRRNrdtmmslLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQcdvlA 291
Cdd:cd15960 169 MMQLYLQIcriaFRHAQqiavQHQFVNFCLASSTRKG-------VSTLSLILATFAFCWVPfAVYSMVADSSYPM----I 237
                       250       260
                ....*....|....*....|....*..
gi 1857425  292 YEKFFLLLAEFNSAMNPIIYSYRDKEM 318
Cdd:cd15960 238 YTYYLVLPAACNSVINPIIYAFRNPDI 264
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
61-322 5.84e-19

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 85.45  E-value: 5.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMfntgpnTRRLTVSTWLLRQGLIDTSL-------T 133
Cdd:cd15049  12 LVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLY------TVYLVMGYWPLGPLLCDLWLaldyvasN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW----------NCICDIENCSNMAPLY 202
Cdd:cd15049  86 ASVMNLLLISFDRYFSVTRpLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWqyfvgertvpDGQCYIQFLDDPAITF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  203 SDSYLVFWaifnlVTFVVMVVLYAHIFgyvrqrtmRMSRhssgprRNRDTMmsllKTVVIVLGAFIICWTPGLVLLLLDV 282
Cdd:cd15049 166 GTAIAAFY-----LPVLVMTILYWRIY--------RETA------RERKAA----RTLSAILLAFIITWTPYNILVLVST 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 1857425  283 CCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15049 223 FCAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
51-322 4.20e-18

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 83.36  E-value: 4.20e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYL--MFNTGPNTRrltVSTWLLRQGLI 128
Cdd:cd15071   2 AYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLaiIINIGPQTE---FYSCLMVACPV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DTSLTASVANLLAIAIERHITVfRMQLHTRM--SNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSD-- 204
Cdd:cd15071  79 LILTQSSILALLAIAVDRYLRV-KIPTRYKSvvTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAWAANSSMGElv 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  205 -----------SYLVFWAIFNLV--TFVVMVVLYAHIFGYVR-QRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIIC 270
Cdd:cd15071 158 ikcqfetvismEYMVYFNFFVWVlpPLLLMLLIYLEVFYLIRkQLNKKVSSSSSDPQKYYGKELKIAKSLALILFLFALS 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 1857425  271 WTPGLVLLLLDVCCPQCD---VLAYEKFFLllAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15071 238 WLPLHILNCITLFCPSCKkpmILTYIAIFL--THGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
60-322 4.26e-18

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 82.79  E-value: 4.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   60 CIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayFYLMFNTgpnTRRLTVSTWLLRQGLIDT-------SL 132
Cdd:cd15067  10 CLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGS--IVMPFSI---LHEMTGGYWLFGRDWCDVwhsfdvlAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 TASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIW--TMAIVMGAIpsVGWNCICDIENCSNMAPLYSDS-YLV 208
Cdd:cd15067  85 TASILNLCVISLDRYWAItDPISYPSRMTKRRALIMIALVWicSALISFPAI--AWWRAVDPGPSPPNQCLFTDDSgYLI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  209 FWAifnLVTF----VVMVVLYAHIFgyvrqrtmrmsRHSSGPRRnrdtmmsLLKTVVIVLGAFIICWTP-GLVLLLLDVC 283
Cdd:cd15067 163 FSS---CVSFyiplVVMLFTYYRIY-----------RAAAKEQK-------AAKTLGIVMGVFILCWLPfFVTNILIGFC 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 1857425  284 CPQCdvLAYEK----FFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15067 222 PSNC--VSNPDilfpLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
57-322 4.36e-18

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 82.91  E-value: 4.36e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA-----YFYLMFNTGPNTRRLTVSTWL--LRQGLID 129
Cdd:cd15350   8 FTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYktlenILIILADMGYLNRRGPFETKLddIMDSLFC 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIpsvgwncicdiencsnMAPLYSDSYLV 208
Cdd:cd15350  88 LSLLGSIFSILAIAADRYITIFHaLRYHNIMTMRRTLVILAIIWTFCGGSGIL----------------MILFFHFVATV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  209 -FWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC 287
Cdd:cd15350 152 iCFTVLFFLMLVLILCLYVHMFLLARSHARKIASLPNHHAQHQRSNMRGAITLTILLGVFVCCWAPFVLHLLLMMFCPMN 231
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 1857425  288 DVLA-YEKFFLL---LAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15350 232 PYCAcYRSLFQVngtLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
57-322 5.54e-18

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 82.41  E-value: 5.54e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWLLRQGLIDTSL---- 132
Cdd:cd15061   7 ILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGV------LVLPLAIIRQLLGYWPLGSHLCDFWIsldv 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 ---TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVG--WNCICDIENCSNMaplYSDSY 206
Cdd:cd15061  81 llcTASILNLCCISLDRYFAITYpLKYRTKRSRRLAITMILAVWVISLLITSPPLVGpsWHGRRGLGSCYYT---YDKGY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 LVFWAIFNL-VTFVVMVVLYAHIFgYVRQRTMRMsrhssgprrnrdtmmslLKTVVIVLGAFIICWTPGLVLLLLDVCCP 285
Cdd:cd15061 158 RIYSSMGSFfLPLLLMLFVYLRIF-RVIAKERKT-----------------AKTLAIVVGCFIVCWLPFFIMYLIEPFCD 219
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 1857425  286 QCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15061 220 CQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
55-322 1.17e-17

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 81.55  E-value: 1.17e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLA---NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL-----AYFYLMFNtgpntrrltvsTWLLRQG 126
Cdd:cd15329   3 IGIVLLIIILGTvvgNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALlvmplAIIYELSG-----------YWPFGEI 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 LID-------TSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIEN-Csn 197
Cdd:cd15329  72 LCDvwisfdvLLCTASILNLCAISVDRYLVITRpLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGvC-- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  198 mapLYSDSYLV-FWAIFnlVTF----VVMVVLYAHIFgyvrqrtmrmsRHSSGPRRNRdtmmsllKTVVIVLGAFIICWT 272
Cdd:cd15329 150 ---QVSQDFGYqIYATF--GAFyiplIVMLVLYYKIY-----------RAAKSERKAI-------KTLGIIMGAFTLCWL 206
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 1857425  273 P-GLVLLLLDVCCPQ---CDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15329 207 PfFILALLRPFLKPIkcsCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
58-322 2.48e-16

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 77.77  E-value: 2.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   58 TVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY--FYLMFNTgpntrrltVSTWLLRQGLIDTSL--- 132
Cdd:cd15059   9 VVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLImpFSLVNEL--------MGYWYFGSVWCEIWLald 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 ----TASVANLLAIAIERHITVFRMQLHTR-MSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYL 207
Cdd:cd15059  81 vlfcTASIVNLCAISLDRYWSVTQAVEYNLkRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQCELSDDPGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  208 VFWAIfnLVTF----VVMVVLYAHIFGYVRQRTMRMSRhssgprrnrdtmmsllkTVVIVLGAFIICWTPGLVLLLLDVC 283
Cdd:cd15059 161 VLFSS--IGSFyiplLIMIIVYARIYRAAKRKERRFTL-----------------VLGVVMGAFVLCWLPFFFTYPLVVV 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 1857425  284 CPQCDVLAYE-KFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15059 222 CKTCGVPELLfKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
57-273 2.65e-16

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 78.02  E-value: 2.65e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTgpNTRRLTVSTWLLRQ--GLIDTSLT- 133
Cdd:cd14969   8 SLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYS--NLSGRWSFGDPGCViyGFAVTFLGl 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCIcDIEN-CSNMAPLYSD------SY 206
Cdd:cd14969  86 VSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSY-VPEGgGTSCSVDWYSkdpnslSY 164
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 LVFWAIFN-LVTFVVMVVLYAHIFGYVRQRTMRMSR--HSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP 273
Cdd:cd14969 165 IVSLFVFCfFLPLAIIIFCYYKIYRTLRKMSKRAARrkNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTP 234
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
55-322 3.91e-16

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 77.39  E-value: 3.91e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYF----YLMFNTGpntrrltvsTWLLRQGLID- 129
Cdd:cd15053   6 FLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMpfavYVEVNGG---------KWYLGPILCDi 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 ------TSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI--CDIENCSnmap 200
Cdd:cd15053  77 yiamdvMCSTASIFNLCAISIDRYIAVTQpIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVpyRDPEECR---- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSDSYLVFWAIFNL-VTFVVMVVLYAHIFgyvrqrtmrmsrhsSGPRRNRDTMmsllKTVVIVLGAFIICWTPGLVLLL 279
Cdd:cd15053 153 FYNPDFIIYSSISSFyIPCIVMLLLYYRIF--------------RALRREKKAT----KTLAIVLGVFLFCWLPFFTLNI 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 1857425  280 LDVCCP-----QCDVlAYEKFFLL--LAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15053 215 LNAICPklqnqSCHV-GPALFSLTtwLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
53-322 8.21e-16

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 76.47  E-value: 8.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   53 MGLGITVCIFIMLA---NLLVMVAIYVNRRFHFPIYYLMANLAAADFFaglayfyLMFNTGPNTRRLTV-STWLLRQGLI 128
Cdd:cd15326   1 ILLGLVLGAFILFAivgNILVILSVVCNRHLRIPTNYFIVNLAIADLL-------LSFTVLPFSATLEIlGYWVFGRIFC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DT-------SLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNcicdiENCSNMAP 200
Cdd:cd15326  74 DIwaavdvlCCTASILSLCAISIDRYIGVrHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWK-----EPAPPDDK 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSDSYLVFWAIF-NLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPrrnrdtmmsllKTVVIVLGAFIICWTP-----G 274
Cdd:cd15326 149 VCEITEEPFYALFsSLGSFYIPLIVILVMYCRVYIVALKFSREKKAA-----------KTLGIVVGMFILCWLPffialP 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 1857425  275 LVLLLLDVCCPQcdvlAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15326 218 LGSLFSHLKPPE----TLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
59-322 8.75e-16

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 76.38  E-value: 8.75e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYF----------YLMFNTGPNTRRLTVSTWLLrqgli 128
Cdd:cd15063  10 LNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLpfsavnevldVWIFGHTWCQIWLAVDVWMC----- 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 dtslTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDI-------ENCSNMAP 200
Cdd:cd15063  85 ----TASILNLCAISLDRYLAITRpIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGimdysgsSSLPCTCE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSD-SYLVFWAIFNL-VTFVVMVVLYAHIFgyvrqRTMRMSRHSSgprrnrdtmmsllKTVVIVLGAFIICWTPGLVLL 278
Cdd:cd15063 161 LTNGrGYVIYSALGSFyIPMLVMLFFYFRIY-----RAARMETKAA-------------KTVAIIVGCFIFCWLPFFTVY 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 1857425  279 LLDVCCPQC-DVLAYEKFFlLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15063 223 LVRAFCEDCiPPLLFSVFF-WLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
51-311 2.08e-15

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 75.67  E-value: 2.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFImlaNLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfYLMFntgPNTRRLTVSTWLLRQGL--- 127
Cdd:cd15055   5 IVLSSISLLTVLG---NLLVIISISHFKQLHTPTNLLLLSLAVADFLVGL---LVMP---FSMIRSIETCWYFGDTFckl 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 ---IDTSLT-ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSvgwNCICDIENCSNMAPLY 202
Cdd:cd15055  76 hssLDYILTsASIFNLVLIAIDRYVAVCDpLLYPTKITIRRVKICICLCWFVSALYSSVLL---YDNLNQPGLIRYNSCY 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  203 SDSYLVF---WAIFNLV-TFV----VMVVLYAHIFGYVRQ--RTMR--MSRHSSGPRRNRDTMMSLLK---TVVIVLGAF 267
Cdd:cd15055 153 GECVVVVnfiWGVVDLVlTFIlpctVMIVLYMRIFVVARSqaRAIRshTAQVSLEGSSKKVSKKSERKaakTLGIVVGVF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 1857425  268 IICWTPGLVLLLLDvccPQCDVLAYE-KFFLLLAEFNSAMNPIIY 311
Cdd:cd15055 233 LLCWLPYYIVSLVD---PYISTPSSVfDVLIWLGYFNSCLNPLIY 274
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
52-312 1.02e-14

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 73.16  E-value: 1.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   52 VMGLGITVCIfimLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfYLMfntgPNTRRLTVS-TWLLRQGLID- 129
Cdd:cd15331   6 ILGLLILATI---IGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAV---LVM----PLSAVYEVSqHWFLGPEVCDm 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 -TSL-----TASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNcicDIENCSNmaPLYS 203
Cdd:cd15331  76 wISMdvlccTASILHLVAIALDRYWAVTNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWK---DEDDLDR--VLKT 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  204 DSYLV----FWAIFNLVT-----FVVMVVLYAHIFgyvrqRTMRMSRHSsgprrnrdtmmslLKTVVIVLGAFIICWTPG 274
Cdd:cd15331 151 GVCLIsqdyGYTIFSTVGafyvpLLLMIIIYWKIY-----QAAKRERKA-------------ARTLAIITGAFVVCWLPF 212
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 1857425  275 LVLLLLDVCCPQCDVLAY-EKFFLLLAEFNSAMNPIIYS 312
Cdd:cd15331 213 FLVALVMPFCGAWQISRFlESFFLWLGYFNSLLNPIIYT 251
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
52-313 1.86e-14

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 73.11  E-value: 1.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   52 VMGLGITVCIFI-MLANLLVMVAIYVNRRF-HFPIYYLMaNLAAADFFAGLayfylmFNTGPNTRRLTVSTWLLRQGL-- 127
Cdd:cd15048   2 VLAVLISVLILVtVIGNLLVILAFIKDKKLrTVSNFFLL-NLAVADFLVGL------VSMPFYIPYTLTGKWPFGKVFck 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 ----ID-TSLTASVANLLAIAIERHITVFRMQLHTRM-SNRRVVVVIVVIWTMAIVMGAIPSVGWNCI----------CD 191
Cdd:cd15048  75 awlvVDyTLCTASALTIVLISLDRYLSVTKAVKYRAKqTKRRTVLLMALVWILAFLLYGPAIIGWDLWtgysivptgdCE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  192 IENCSNMAplysdsYLVFWAIFNLVT-FVVMVVLYAHIFGYVRQRTmRMSRHSSGP-----------RRNRDTM-----M 254
Cdd:cd15048 155 VEFFDHFY------FTFITSVLEFFIpFISVSFFNLLIYLNIRKRS-RRRPLRSVPilpasqnpsraRSQREQVklrrdR 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1857425  255 SLLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQC-DVLAYEKFFLLLAeFNSAMNPIIYSY 313
Cdd:cd15048 228 KAAKSLAILVLVFLICWAPyTILTIIRSFCSGSCvDSYLYEFTFWLLW-TNSAINPFLYAA 287
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
51-311 2.16e-14

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 72.87  E-value: 2.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLgitVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFylmfntgPNTRRLTVS-TWLLRQGLID 129
Cdd:cd15058   5 LLLAL---IILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVV-------PLGATIVVTgKWQLGNFWCE 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 --TSL-----TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWtmaIVMGAIPSV-------------GWNC 188
Cdd:cd15058  75 lwTSVdvlcvTASIETLCVIAVDRYIAITRpLRYQVLLTKRRARVIVCVVW---IVSALVSFVpimnqwwrandpeANDC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  189 ICDIENC---SNMAPLYSDSYLVFWaifnlVTFVVMVVLYAHIF-------GYVRQRTMRMSRHSSGP-----------R 247
Cdd:cd15058 152 YQDPTCCdfrTNMAYAIASSVVSFY-----IPLLIMIFVYARVFliatrqlQLIDKRRLRFQSECPAPqttspegkrssG 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1857425  248 RNRDTMMSL-----LKTVVIVLGAFIICWTPGLVLLLLDVCCPQCdvLAYEKFFLL--LAEFNSAMNPIIY 311
Cdd:cd15058 227 RRPSRLTVVkehkaLKTLGIIMGTFTLCWLPFFIANIINVFNRNL--PPGEVFLLLnwLGYINSGLNPIIY 295
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
64-324 2.42e-14

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 72.31  E-value: 2.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   64 MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFA--------GLAYFYLMFNTGPntrRLTVSTWLLRQglidTSLTAS 135
Cdd:cd15001  14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLlvfcvplkTAEYFSPTWSLGA---FLCKAVAYLQL----LSFICS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  136 VANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPS--------VGWNCICDIENCSNMAPlySDSY 206
Cdd:cd15001  87 VLTLTAISIERYYVIlHPMKAKSFCTIGRARKVALLIWILSAIL-ASPVlfgqglvrYESENGVTVYHCQKAWP--STLY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 LVFWAIFNLVT-----FVVMVVLYAhifgyvrqrtmrmsrhssgprrnRDTMMSLLKTVVIVLGAFIICWTP----GLVL 277
Cdd:cd15001 164 SRLYVVYLAIViffipLIVMTFAYA-----------------------RDTRKQVIKMLISVVVLFAVCWGPllidNLLV 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 1857425  278 LLLDVCCPQCDVLAY-EKFFLLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15001 221 SFDVISTLHTQALKYmRIAFHLLSYANSCINPIIYAF----MSKNFRS 264
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
51-273 2.91e-14

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 72.37  E-value: 2.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVC-IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15083   1 YVLGIFILIIgLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSL-TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN--------CICDIENCSNMA 199
Cdd:cd15083  81 GLFgIMSINTLAAIAVDRYLVITRpMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSryvlegllTSCSFDYLSRDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 plYSDSYLVFWAIFNLV-TFVVMVVLYAHIFGYVRQRTMRMSRHS--------SGPRRNRDTMMSLLKTVVIVLGAFIIC 270
Cdd:cd15083 161 --ANRSYVICLLIFGFVlPLLIIIYCYSFIFRAVRRHEKAMKEMAkrfskselSSPKARRQAEVKTAKIALLLVLLFCLA 238

                ...
gi 1857425  271 WTP 273
Cdd:cd15083 239 WTP 241
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
57-322 4.42e-14

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 71.73  E-value: 4.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYL--MFNTGPNTRrltVSTWLLRQGLIDTSLTA 134
Cdd:cd15070   8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLaiVVSLGVTIH---FYSCLFMSCLLVVFTHA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  135 SVANLLAIAIERHItvfRMQLHTR----MSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENcSNMAPLYSD------ 204
Cdd:cd15070  85 SIMSLLAIAVDRYL---RVKLTVRyrivTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLES-VNTTPLQCQftsvmr 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  205 -SYLVFWAIFN--LVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLD 281
Cdd:cd15070 161 mDYMVYFSFFTwiLIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGREFKTAKSLALVLFLFAVCWLPLSIINCVV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 1857425  282 VCCPQCDVLAyekFFL--LLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15070 241 YFNPKVPKIA---LYLgiLLSHANSMMNPIVYACKIKKFKETY 280
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
53-322 5.91e-14

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 70.98  E-value: 5.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   53 MGLGITVCIFIMLA---NLLVMVAIYVNRRFHFPIYYLMANLAAADFFaglayfyLMFNTGPNTRRLTV-STWLLRQGLI 128
Cdd:cd15062   1 IVVGVALGAFILFAiggNLLVILSVACNRHLRTPTHYFIVNLAVADLL-------LSFTVLPFSATLEVlGYWAFGRIFC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DT-------SLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN--CICDIENCS-N 197
Cdd:cd15062  74 DVwaavdvlCCTASIMSLCVISVDRYIGVRYpLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKepAPADEQACGvN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  198 MAPlysdSYLVFWAIFNL-VTFVVMVVLYAHIFgyvrQRTMRMSRHSSGPrrnrdtmmsllKTVVIVLGAFIICWTPGLV 276
Cdd:cd15062 154 EEP----GYVLFSSLGSFyLPLAIILVMYCRVY----VVAFKFSREKKAA-----------KTLGIVVGAFVLCWFPFFV 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 1857425  277 LLLLDVCCPQCDVL-AYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15062 215 VLPLGSLFSTLKPPePVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
64-322 7.18e-14

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 70.98  E-value: 7.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   64 MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFfagLAYFYLMfntgPNTRRLTVS-TWLLRQGLID-------TSLTAS 135
Cdd:cd15333  19 TLSNAFVIATIYLTRKLHTPANYLIASLAVTDL---LVSILVM----PISIVYTVTgTWTLGQVVCDiwlssdiTCCTAS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  136 VANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCS----NMAPLYSDSYLVFW 210
Cdd:cd15333  92 ILHLCVIALDRYWAITdAVEYSKKRTPKRAAVMIALVWVISISI-SLPPFFWRQAKAEEEVSecvvNTDHILYTVYSTVG 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  211 AIFnlVTFVVMVVLYAHIFGYVRQRTMRMSrhssgprrnrdtmmsllKTVVIVLGAFIICWTPGLVLLLLDVCCPQC--D 288
Cdd:cd15333 171 AFY--IPTLLLIALYGRIYVEARARERKAT-----------------KTLGIILGAFIVCWLPFFIISLVLPICKDAcwF 231
                       250       260       270
                ....*....|....*....|....*....|....
gi 1857425  289 VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15333 232 HLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
57-322 8.44e-14

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 70.98  E-value: 8.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayFYLMFntgpNTRRLTVSTWLLRQG--LIDTSL-- 132
Cdd:cd15056   8 SLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAV--LVMPF----GAIELVNNRWIYGETfcLVRTSLdv 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 ---TASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIP-SVGWNCIcDIENCSNMAPLYSDSYLV 208
Cdd:cd15056  82 lltTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPiMQGWNHI-GIEDLIAFNCASGSTSCV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  209 FWA------IFNLVTF----VVMVVLYAHIFGYVRQ--RTMRM------SRHSSGPRRNRD--TMMSLLKTVVIVLGAFI 268
Cdd:cd15056 161 FMVnkpfaiICSTVAFyipaLLMVLAYYRIYVAAREqaHQIRSlqragsSNHEADQHRNSRmrTETKAAKTLGIIMGCFC 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 1857425  269 ICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15056 241 VCWAPFFVTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
51-322 8.84e-14

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 71.12  E-value: 8.84e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY--FYLMFNTGPNTrrlTVSTWLLRQGLI 128
Cdd:cd15069   2 TYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAipFAITISLGFCT---DFHSCLFLACFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DTSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCS----------- 196
Cdd:cd15069  79 LVLTQSSIFSLLAVAVDRYLAIkVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATNNStnpadhgtnhs 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  197 ---------NMAPLysdSYLVFWAIFN--LVTFVVMVVLYAHIFgYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLG 265
Cdd:cd15069 159 cclisclfeNVVPM---SYMVYFNFFGcvLPPLLIMLVIYIKIF-LVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVG 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1857425  266 AFIICWTPglvlllldVCCPQCDVLAYEKF-----------FLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15069 235 IFALCWLP--------VHILNCITLFQPEFskskpkwamnvAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
53-322 1.21e-13

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 69.94  E-value: 1.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   53 MGLGITVCIFIMLA---NLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGPNTrrltVSTWLLRQGLID 129
Cdd:cd15327   1 VGVGVFLAIFILMAivgNILVILSVACNRHLQTVTNYFIVNLAIADLL--LSTTVLPFSATLEV----LGFWAFGRVFCD 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 T-------SLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW-------NCICDIEN 194
Cdd:cd15327  75 IwaavdvlCCTASILSLCVISVDRYVGVkHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWkeppppdESICSITE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  195 csnmaplySDSYLVFWAIFNL-VTFVVMVVLYAHIFGYvrqrTMRMSRHSSGPrrnrdtmmsllKTVVIVLGAFIICWTP 273
Cdd:cd15327 155 --------EPGYALFSSLFSFyLPLMVILVMYFRVYVV----ALKFSREKKAA-----------KTLAIVVGVFILCWFP 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 1857425  274 GLVLLLLDVCCPQCD-VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15327 212 FFFVLPLGSFFPALKpSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
59-273 1.64e-13

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 69.94  E-value: 1.64e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfYLMFNTGPNTRRLTV----------STWLLRQGLI 128
Cdd:cd15136  10 VFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGI---YLGLLAIVDAKTLGEyynyaidwqtGAGCKTAGFL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DT-SLTASVANLLAIAIER-HITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVG-----WNCIC---DIENcsnm 198
Cdd:cd15136  87 AVfSSELSVFTLTVITLERwYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGvssysKTSIClpfETET---- 162
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1857425  199 apLYSDSYLVFWAIFNLVTFVVMVVLYAHIFgyvrqrtmRMSRHSSGPRRNRDTMMSllKTVVIVLGAFIICWTP 273
Cdd:cd15136 163 --PVSKAYVIFLLLFNGLAFLIICGCYIKIY--------LSVRGSGRAANSNDTRIA--KRMALLVFTDFLCWAP 225
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
51-313 3.24e-13

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 69.40  E-value: 3.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFimlANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTWLLRQGL--- 127
Cdd:cd15317   5 IVLVLAMLITVS---GNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPF------SMIRTVETCWYFGDLFckf 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 ---IDTSL-TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTM-AIVMGAIPSVGWNcICDIENCSNMAPL 201
Cdd:cd15317  76 htgLDLLLcTTSIFHLCFIAIDRYYAVCDpLRYPSKITVQVAWRFIAIGWLVpGIYTFGLIYTGAN-DEGLEEYSSEISC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  202 YSDSYLVFWAIFNLVTFV-------VMVVLYAHIFGYVRQ---------RTMRMSRHSSGPRRNRDTMMSlLKTVVIVLG 265
Cdd:cd15317 155 VGGCQLLFNKIWVLLDFLtffipclIMIGLYAKIFLVARRqarkiqnmeDKFRSSEENSSKASASRERKA-AKTLAIVMG 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 1857425  266 AFIICWTPGLVLLLLD----VCCPQCdvlAYEKfFLLLAEFNSAMNPIIYSY 313
Cdd:cd15317 234 IFLFCWLPYFIDTIVDeysnFITPAI---VFDA-VIWLGYFNSAFNPFIYAF 281
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
63-322 5.72e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 68.07  E-value: 5.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   63 IMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFF-AGLAYFYLMFntgpntRRLTVSTWLLRQGLIDTSLT-------A 134
Cdd:cd15310  14 IVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLvATLVMPWVVY------LEVTGGVWNFSRICCDVFVTldvmmctA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  135 SVANLLAIAIERHITVFRMQLH----TRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAP---LYSdSYL 207
Cdd:cd15310  88 SILNLCAISIDRYTAVVMPVHYqhgtGQSSCRRVSLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPdfvIYS-SVV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  208 VFWaifnlVTFVVMVVLYAHIFGYVRqrtmrmsrhssgpRRNRDTMMsllktVVIVLGAFIICWTPGLVLLLLDVCCPQC 287
Cdd:cd15310 167 SFY-----LPFGVTLLVYVRIYVVLL-------------REKKATQM-----LAIVLGAFIVCWLPFFLTHILNTHCQAC 223
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 1857425  288 DVL-AYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15310 224 HVPpELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
53-324 9.27e-13

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 68.01  E-value: 9.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   53 MGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayFYLMFNTGPNTRRltvsTWLLRQGLIDT-- 130
Cdd:cd14993   4 IVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSL--FCMPLTLLENVYR----PWVFGEVLCKAvp 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 -----SLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIV--------------MGAIPSVGWNCIC 190
Cdd:cd14993  78 ylqgvSVSASVLTLVAISIDRYLAICYpLKARRVSTKRRARIIIVAIWVIAIIimlpllvvyeleeiISSEPGTITIYIC 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  191 DIENCSNMAPLYsdsYLVFW-AIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMS---LLKTVVIVLGA 266
Cdd:cd14993 158 TEDWPSPELRKA---YNVALfVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRILRSkkkVARMLIVVVVL 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1857425  267 FIICWTPGLVLLLLDVCCPQCDVLAYE------KFFLLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd14993 235 FALSWLPYYVLSILLDFGPLSSEESDEnfllilPFAQLLGYSNSAINPIIYCF----MSKKFRR 294
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
51-327 2.05e-12

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 66.77  E-value: 2.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-----LAYFYLMFNTGPNTRRLTVsTWLLRQ 125
Cdd:cd15295   2 VLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGaisipLYIPYTLTNRWDFGRGLCV-FWLVID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  126 GLidtSLTASVANLLAIAIERHITV-----FRMQlHTRMSnrRVVVVIVVIWTMAIVMGAIPSVGWNCICDiENCSNMAP 200
Cdd:cd15295  81 YL---LCTASVYNIVLISYDRYQSVsnavsYRNQ-QTATL--RIVTQMVAVWVLAFLVHGPAILVSDSWKT-EDGECEPE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSDSYLVfwAIFNLVTFVVMVVLYAHiFGYVRQRTMRmsrhssgpRRNRDTMMSllKTVVIVLGAFIICWTP-GLVLLL 279
Cdd:cd15295 154 FFSNWYIL--AITSVLEFLVPVILVAY-FNTQIYWSLW--------KRLRDRKLA--KSLAIILGTFAICWAPySLFTII 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 1857425  280 LDVCCPQCDVLAYEKFFLLLAeFNSAMNPIIYSYRDKEMSATFRQILC 327
Cdd:cd15295 221 RAACEKHRGSPWYNFAFWLQW-FNSFINPFLYPLCHKRFRKAFLKIFC 267
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
54-313 3.75e-12

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 66.30  E-value: 3.75e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   54 GLGITVCIFIMLA---NLLVMVAIYVNRRFHFPIY-YLMANLAAADFFagLAYFYLMFNTGpntrRLTVSTWLLRQGL-- 127
Cdd:cd15057   2 ITGCILYLLVLLTllgNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLL--VAILVMPWAAV----NEVAGYWPFGSFCdv 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 ---IDTSL-TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP-----------SVGWNCICD 191
Cdd:cd15057  76 wvsFDIMCsTASILNLCVISVDRYWAISSpFRYERRMTRRRAFIMIAVAWTLSALISFIPvqlgwhraddtSEALALYAD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  192 IENC-SNMAPLY--SDSYLVFWaifnlVTFVVMVVLYAHIFGYVRQRTMRMS------RHSSGPRRNRDTMM----SLLK 258
Cdd:cd15057 156 PCQCdSSLNRTYaiSSSLISFY-----IPVAIMIVTYTRIYRIARRQIRRIAaleraaQESTNPDSSLRSSLrretKALK 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1857425  259 TVVIVLGAFIICWTPGLVLLLLDVCC------PQCDVLAYEKFFLLLAEFNSAMNPIIYSY 313
Cdd:cd15057 231 TLSIIMGVFVCCWLPFFILNCVLPFCdlrtaqFPCVPDTTFIVFVWLGWANSSLNPIIYAF 291
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
51-322 5.34e-12

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 65.24  E-value: 5.34e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA----YFYLMFNTGPNTRRLTVSTWLLRqg 126
Cdd:cd15308   2 AALVGGVLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLvlplYVYSEFQGGVWTLSPVLCDALMT-- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 lIDTSL-TASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIEncSNMAPLYSD 204
Cdd:cd15308  80 -MDVMLcTASIFNLCAISVDRFIAVsVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRD--PAVCKLEDN 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  205 SYLVFWAIFNL-VTFVVMVVLYAHIFgyvrqrtmrmsrhsSGPRRNRDTMmsllKTVVIVLGAFIICWTPGLVLLLLDVC 283
Cdd:cd15308 157 NYVVYSSVCSFfIPCPVMLVLYCAMF--------------RGLGRERKAM----RVLPVVVGAFLFCWTPFFVVHITRAL 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 1857425  284 CPQCDV-LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15308 219 CESCSIpPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
51-326 6.40e-12

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 65.37  E-value: 6.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVC-IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLid 129
Cdd:cd15074   1 IIIGIYLTVIgILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGF-- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLT---ASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN--------CICDIENCSNM 198
Cdd:cd15074  79 CGFLfgcCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGsygpepfgTSCSIDWTGAS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  199 APLYSDSYLVFWAIFN-LVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVL 277
Cdd:cd15074 159 ASVGGMSYIISIFIFCyLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 1857425  278 LLLDVCCPQCDVLAyeKFFL---LLAEFNSAMNPIIYSYrdkeMSATFRQIL 326
Cdd:cd15074 239 SMWSAFGSPDSVPI--LASIlpaLFAKSSCMYNPIIYLL----FSSKFRQDL 284
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
51-323 7.77e-12

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 65.22  E-value: 7.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWLLRQGLID- 129
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITL------FNTPFTFVRAVNNTWIFGLFMCHf 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 ------TSLTASVANLLAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMgAIP---SVGWNCICDIENCSNMA- 199
Cdd:cd15202  76 snfaqyCSVHVSAYTLTAIAVDRYQAIMH-PLKPRISKTKAKFIIAVIWTLALAF-ALPhaiCSKLETFKYSEDIVRSLc 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 -PLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGP-----------RRNRDTMMSLLKTVVIVlgaF 267
Cdd:cd15202 154 lEDWPERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPgdatteryfalRRKKKKVIKMLMVVVVL---F 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1857425  268 IICWTPGLVLllldVCCPQCDVLAYEKF-------FLLLAEFNSAMNPIIYSYrdkeMSATFR 323
Cdd:cd15202 231 ALCWLPFNIY----VLLLSSKPDYLIKTinavyfaFHWLAMSSTCYNPFIYCW----LNERFR 285
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
51-322 1.04e-11

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 64.60  E-value: 1.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFImLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWLLRQGLIDT 130
Cdd:cd15297   3 IVLVAGSLSLVTI-IGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGV------FSMNLYTLYTVIGYWPLGPVVCDL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SL-------TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI----------CDI 192
Cdd:cd15297  76 WLaldyvvsNASVMNLLIISFDRYFCVTKpLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIvggrtvpegeCYI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  193 ENCSNMAPLYSDSYLVFWaifnlVTFVVMVVLYAHIfgyvrqrtmrmSRHSSGPRRnrdtmmsLLKTVVIVLGAFIICWT 272
Cdd:cd15297 156 QFFSNAAVTFGTAIAAFY-----LPVIIMTVLYWQI-----------SRASSREKK-------VTRTILAILLAFIITWT 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 1857425  273 PGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15297 213 PYNVMVLINTFCASCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
48-322 1.57e-11

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 63.84  E-value: 1.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   48 VSKLVMGLGITVCIFimlANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-----LAYFYLMFNTgpntrrltvstWL 122
Cdd:cd15330   2 ITSLFLGTLILCAIF---GNACVVAAIALERSLQNVANYLIGSLAVTDLMVSvlvlpMAALYQVLNK-----------WT 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  123 LRQGLIDTSL-------TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIEN 194
Cdd:cd15330  68 LGQVTCDLFIaldvlccTSSILHLCAIALDRYWAITDpIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSD 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  195 cSNMAPLYSDSYLVFWAIFN--LVTFVVMVVLYAHIFgyvrqrtmrmsrhsSGPRRNRDTmmslLKTVVIVLGAFIICWT 272
Cdd:cd15330 148 -PDACTISKDPGYTIYSTFGafYIPLILMLVLYGRIF--------------KAAARERKT----VKTLGIIMGTFILCWL 208
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 1857425  273 PglvLLLLDVCCPQCDVLAYEKFFL-----LLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15330 209 P---FFIVALVLPFCESTCHMPELLgaiinWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
57-311 2.86e-11

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 63.41  E-value: 2.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCifimlANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFylmfntgPNTRRLTVSTWLLRQGL-------ID 129
Cdd:cd15314  13 VTVC-----GNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVM-------PPSMVRSVETCWYFGDLfckihssFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSL-TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMG-AIPSVGWNCICD-------IENC-SNM 198
Cdd:cd15314  81 ITLcTASILNLCFISIDRYYAVCQpLLYRSKITVRVVLVMILISWSVSALVGfGIIFLELNIKGIyynhvacEGGClVFF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  199 APLYSDSYLVFwaIFNLVTFVvMVVLYAHIFgYVRQR-------TMRMSRHSSGPRRNRDTmmsllKTVVIVLGAFIICW 271
Cdd:cd15314 161 SKVSSVVGSVF--SFYIPAVI-MLCIYLKIF-LVAQRqarsiqsARTKSGASSSKMERKAT-----KTLAIVMGVFLLCW 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 1857425  272 TPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIY 311
Cdd:cd15314 232 TPFFLCNIIDPFINYSIPPVLIEVLNWLGYSNSTLNPFIY 271
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
55-326 4.74e-11

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 63.04  E-value: 4.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLANLLVMVaIYVNRRFHFPIYYLMANLAAADFFAGLAYF------YLMFNTGPNTRRLTVSTWLLRQGLI 128
Cdd:cd14978   6 VLPVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALplfllpYIADYSSSFLSYFYAYFLPYIYPLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DTSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGA--------IPSVGWNCICDIENCSNMA 199
Cdd:cd14978  85 NTFQTASVWLTVALTVERYIAVCHpLKARTWCTPRRARRVILIIIIFSLLLNLprffeyevVECENCNNNSYYYVIPTLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSDSYLVFW-----AIFNLVTFVVMVVLYAHIFGYVRQRTMRM--------SRHSSGPRRNRDTMMsllktVVIVLGA 266
Cdd:cd14978 165 RQNETYLLKYYfwlyaIFVVLLPFILLLILNILLIRALRKSKKRRrllrrrrrLLSRSQRRERRTTIM-----LIAVVIV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1857425  267 FIICWTPGLVLLLLDVCCPQCD----VLAYEKFFLLLAEFNSAMNPIIYSYrdkeMSATFRQIL 326
Cdd:cd14978 240 FLICNLPAGILNILEAIFGESFlspiYQLLGDISNLLVVLNSAVNFIIYCL----FSSKFRRTF 299
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
45-329 4.75e-11

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 62.66  E-value: 4.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   45 WNTVskLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMfntgpnTRRLTVSTWLLR 124
Cdd:cd15299   1 WQVV--LIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLF------TTYIIMNRWALG 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  125 QGLIDTSLT-------ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI------- 189
Cdd:cd15299  73 NLACDLWLSidyvasnASVMNLLVISFDRYFSITRpLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFvgkrtvp 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  190 ---CDIENCSNMAPLYSDSYLVFWaifnlVTFVVMVVLYAHIFgyvrQRTMRMSRHSsgprrnrdtmmsllKTVVIVLGA 266
Cdd:cd15299 153 pdeCFIQFLSEPIITFGTAIAAFY-----LPVTIMTILYWRIY----KETIKEKKAA--------------QTLSAILLA 209
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1857425  267 FIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQ 329
Cdd:cd15299 210 FIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 272
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
53-313 8.36e-11

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 61.67  E-value: 8.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   53 MGLGITVCIFIML-ANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWL-LRQGLIDT 130
Cdd:cd14964   1 TTIILSLLTCLGLlGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCyLIYLLWYG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209
Cdd:cd14964  81 ANLASIWTTLVLTYHRYFALcGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYLT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQCD 288
Cdd:cd14964 161 WGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPfSIVFILHALVAAGQG 240
                       250       260
                ....*....|....*....|....*
gi 1857425  289 VLAYEKFFLLLAEFNSAMNPIIYSY 313
Cdd:cd14964 241 LNLLSILANLLAVLASTLNPFIYCL 265
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
55-322 9.70e-11

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 61.45  E-value: 9.70e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIM---LANLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGPNTR------RLTVSTWLLRQ 125
Cdd:cd15325   3 LGVILGGFILfgvLGNILVILSVACHRHLQTVTHYFIVNLAVADLL--LTSTVLPFSAIFEILgywafgRVFCNIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  126 GLidtSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW-------NCICDIENcsn 197
Cdd:cd15325  81 VL---CCTASIMSLCIISIDRYIGVsYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWkepapedETICQITE--- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  198 maplySDSYLVFWAIFNL-VTFVVMVVLYAHIFGYvrqrTMRMSRHSSGPrrnrdtmmsllKTVVIVLGAFIICWTPGLV 276
Cdd:cd15325 155 -----EPGYALFSALGSFyLPLAIILVMYCRVYVV----ALKFSREKKAA-----------KTLGIVVGCFVLCWLPFFL 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 1857425  277 LLLLDVCCPqcDVLAYEKFFLL---LAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15325 215 VMPIGSIFP--AYKPSDTVFKItfwLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
55-323 2.37e-10

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 60.35  E-value: 2.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLA---NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY--FYLMFntgpntrrLTVSTWLLRQGLID 129
Cdd:cd15334   3 ISLTLSILALMTtaiNSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVmpFSIMY--------IVKETWIMGQVVCD 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 -------TSLTASVANLLAIAIERHITVFRMQLHTR-MSNRRVVVVIVVIWTMAIVMgAIPSVGWNCI-------CDIEN 194
Cdd:cd15334  75 iwlsvdiTCCTCSILHLSAIALDRYRAITDAVEYARkRTPKHAGIMIAVVWIISIFI-SMPPLFWRHQttsredeCIIKH 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  195 CSNMAPLYSdsylVFWAIFnlVTFVVMVVLYAHIFgyvrqrtmrmsRHSSGPRRNRDTMMsllktvvIVLGAFIICWTPG 274
Cdd:cd15334 154 DHIVFTIYS----TFGAFY--IPLALILILYYKIY-----------RAATRERKAATTLG-------LILGAFVICWLPF 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 1857425  275 LVLLLLDVCCPQCDV-LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFR 323
Cdd:cd15334 210 FVKEVIVNTCDSCYIsEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
58-326 2.54e-10

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 60.72  E-value: 2.54e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   58 TVCIFIMLANLLVMVAIYVNRRFHFPIY-YLMANLAAADFFAGlayFYLMFNTGPNT----RRLTVSTWLLRQG------ 126
Cdd:cd14980   9 IIGILALIGNILVIIWHISSKKKKKKVPkLLIINLAIADFLMG---IYLLIIAIADQyyrgRYAQYSEEWLRSPpcllac 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 -LIDTSLTASVANLLAIAIERHIT-VFRMQLHtRMSNRRVVVVIVVIWTMAIVMGAIPSV------------GWNCICDI 192
Cdd:cd14980  86 fLVSLSSLMSVLMMLLITLDRYICiVYPFSNK-RLSYKSAKIILILGWLFSIIFAAIPILysinqpgdnrlyGYSSICMP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  193 ENCSNmapLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSgprrNRDTMMSlLKTVVIVLGAFiICWT 272
Cdd:cd14980 165 SNVSN---PYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARRSSS----KRDKRIA-IRLALILITDL-ICWL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 1857425  273 PGLVLLLLDVC-CPQCDVLAYeKFFLLLA-EFNSAMNPIIYSYRdkemSATFRQIL 326
Cdd:cd14980 236 PYYIVIFSGLLtSTEIDIHVL-QFIAILAlPLNSAINPYLYTLT----TPTFKRDF 286
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
61-322 4.38e-10

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 59.55  E-value: 4.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGPNTrrltVSTWLLRQGLIDTSL-------T 133
Cdd:cd15321  18 LFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADIL--VATLIIPFSLANEL----MGYWYFRKTWCEIYLaldvlfcT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAI 212
Cdd:cd15321  92 SSIVHLCAISLDRYWSVSRaIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLNEEAWYILSSS 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  213 FN--LVTFVVMVVLYAHIFGYVRQRTMRMSRhssgprrnrdtmmsllkTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVL 290
Cdd:cd15321 172 IGsfFAPCLIMILVYLRIYLIAKNREKRFTF-----------------VLAVVIGVFVLCWFPFFFSYSLGAICPELCKV 234
                       250       260       270
                ....*....|....*....|....*....|....
gi 1857425  291 AYE--KFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15321 235 PHSlfQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
57-322 4.41e-10

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 59.75  E-value: 4.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFfaGLAYFYLMFNtgpntrrltVSTWLLRQGLIDTSL---- 132
Cdd:cd15060   8 SVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADL--AVAIFVLPLN---------VAYFLLGKWLFGIHLcqmw 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 --------TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICD-IENCSNMAPLY 202
Cdd:cd15060  77 ltcdilccTASILNLCAIALDRYWAIHDpINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWPEnFTETTPCTLTE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  203 SDSYLVFWAIFNL-VTFVVMVVLYAHIFgyvrqrtmrmsRHSSGPRRnrdtmmsLLKTVVIVLGAFIICWTPGLVLLLLD 281
Cdd:cd15060 157 EKGYVIYSSSGSFfIPLLIMTIVYVKIF-----------IATSKERR-------AARTLGIIMGVFVVCWLPFFLMYVIL 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 1857425  282 VCCPQCDVLA-YEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15060 219 PFCETCSPSAkVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
51-322 1.54e-09

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 58.22  E-value: 1.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFI-MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYF-----YLMFNTGPNTRRLTVSTWLlr 124
Cdd:cd15302   1 ILLALITAILSIItVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMpfytvYVLNGDYWPLGWVLCDLWL-- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  125 qGLIDTSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCIC----DIENCSNMA 199
Cdd:cd15302  79 -SVDYTVCLVSIYTVLLITIDRYCSVkIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTgqgrSLPEGECYV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSDSYL--VFWAIFNLVTFVVMVVLYAHIFgyvrqRTMRMSRHSsgprrnrdtmmslLKTVVIVLGAFIICWTPGLVL 277
Cdd:cd15302 158 QFMTDPYFnmGMYIGYYWTTLIVMLILYAGIY-----RAANRARKA-------------LRTITFILGAFVICWTPYHIL 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 1857425  278 LLLDVCC--PQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15302 220 ATIYGFCeaPPCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
65-311 1.73e-09

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 58.19  E-value: 1.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   65 LANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRrltvstWLLRQGL------IDT-SLTASVA 137
Cdd:cd15393  16 VGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQR------WVLPRFMcpfcpfVQVlSVNVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  138 NLLAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMA-----PLYSDSYlvFWAI 212
Cdd:cd15393  90 TLTVIAVDRYRAVIH-PLKARCSKKSAKIIILIIWILALLVALPVALALRVEELTDKTNNGVkpfclPVGPSDD--WWKI 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  213 FNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMS--------LLKTVVIVLGAFIICWTPGLVLLLLDVCC 284
Cdd:cd15393 167 YNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDVRDDeilknkkkVIKMLIIVVALFALCWLPLQTYNLLNEIK 246
                       250       260       270
                ....*....|....*....|....*....|.
gi 1857425  285 PQCDVLAYEKFFLL----LAEFNSAMNPIIY 311
Cdd:cd15393 247 PEINKYKYINIIWFcshwLAMSNSCYNPFIY 277
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
55-311 1.80e-09

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 58.38  E-value: 1.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIfIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWLLRQGLID--TSL 132
Cdd:cd15959   7 LSLAILV-IVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGL------LVVPPGATILLTGHWPLGTTVCElwTSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 -----TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVG--W---------NCICDIENC 195
Cdd:cd15959  80 dvlcvTASIETLCAIAVDRYLAITNpLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqwWrdgadeeaqRCYDNPRCC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  196 ---SNMAPLYSDSYLVFWaifnlVTFVVMVVLYAHIFgYVRQRTMRMSR--------------HSSGPRRNRDTMM---- 254
Cdd:cd15959 160 dfvTNMPYAIVSSTVSFY-----VPLLVMIFVYVRVF-VVATRQVRLIRkdkvrfppeesppaESRPACGRRPSRLlaik 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1857425  255 --SLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQcdvLAYEKFFLL---LAEFNSAMNPIIY 311
Cdd:cd15959 234 ehKALKTLGIIMGTFTLCWLPFFVANIIKVFCRS---LVPDPAFLFlnwLGYANSAFNPIIY 292
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
51-322 3.10e-09

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 56.88  E-value: 3.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRltvstWLLRQGLIDT 130
Cdd:cd15328   2 LVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRR-----WQLGRSLCQV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SL-------TASVANLLAIAIERHITVFRMQLHTRMSNRRVV-VVIVVIWTMAIVMGAIP-SVGWNCIC--DIENCS-NM 198
Cdd:cd15328  77 WIsfdvlccTASIWNVTAIALDRYWSITRHLEYTLRTRRRISnVMIALTWALSAVISLAPlLFGWGETYseDSEECQvSQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  199 APlysdSYLVFwAIFNLVTFVVMVVLYAHIFGYvrqrtmrmsrhSSGPRRNRDTMMsllktVVIVLGAFIICWTPGLVLL 278
Cdd:cd15328 157 EP----SYTVF-STFGAFYLPLCVVLFVYWKIY-----------KAAQKEKRAALM-----VGILIGVFVLCWIPFFLTE 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 1857425  279 LLDVCCpQCDVLA-YEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15328 216 LISPLC-SCDIPPiWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
52-313 3.16e-09

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 57.36  E-value: 3.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   52 VMGLGITVCIFI-MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYF-YLMFntgpntrRLTVSTWLLRQGL-- 127
Cdd:cd15312   2 AMYLFMAGAILLtVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMpYSMV-------RSVESCWYFGDLFck 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 IDTSL-----TASVANLLAIAIERHITVFRmQLH--TRMSNRRVVVVIVVIWTMAI------VMGAIPSVGWNCICDIEN 194
Cdd:cd15312  75 IHSSLdmmlsTTSIFHLCFIAVDRYYAVCD-PLHyrTKITTPVIKVFLVISWSVPClfafgvVFSEVNLEGIEDYVALVS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  195 CSNMAPLYSDSylvFWA-IFNLVTFV----VMVVLYAHIFgYVRQRTMRMSRHSSGPRRNRDTMMSLL-------KTVVI 262
Cdd:cd15312 154 CTGSCVLIFNK---LWGvIASLIAFFipgtVMIGIYIKIF-FVARKHAKVINNRPSVTKGDSKNKLSKkkerkaaKTLSI 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 1857425  263 VLGAFIICWTPGLVLLLLDvccPQCD----VLAYEKfFLLLAEFNSAMNPIIYSY 313
Cdd:cd15312 230 VMGVFLLCWLPFFVATLID---PFLNfstpVDLFDA-LVWLGYFNSTCNPLIYGF 280
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
64-322 3.30e-09

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 56.90  E-value: 3.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   64 MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGlayfylMFNTGPNTRRLTVSTWLLRQGLIDTSLT-------ASV 136
Cdd:cd17790  15 VTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIG------AFSMNLYTTYILMGHWALGTVACDLWLAldyvasnASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  137 ANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI----------CDIENCSNMAPLYSDS 205
Cdd:cd17790  89 MNLLIISFDRYFSITRpLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLvgertvlagqCYIQFLSQPIITFGTA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  206 YLVFWaifnlVTFVVMVVLYAHIFgyvrQRTMRMSRHSsgprrnrdtmmsllKTVVIVLGAFIICWTPGLVLLLLDVCCP 285
Cdd:cd17790 169 IAAFY-----LPVTIMIILYWRIY----RETIKEKKAA--------------RTLSAILLAFILTWTPYNIMVLVSTFCK 225
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 1857425  286 QCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd17790 226 DCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
57-324 4.41e-09

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 56.96  E-value: 4.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVC---IFI--MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFA---GLAY-FYLMFNTGPNtrRLTVSTWLLRQGL 127
Cdd:cd15134   3 ITIIygiIFVtgVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLlilGLPFeLYTIWQQYPW--VFGEVFCKLRAFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 IDTSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCSNMAPLYSDSY 206
Cdd:cd15134  81 SEMSSYASVLTITAFSVERYLAIcHPLRSHTMSKLSRAIRIIIAIWIIAFVC-ALPFAIQTRIVYLEYPPTSGEALEESA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 L------------VFWA---IFNLVTFVVMVVLYAHIFGYVRQRTM--RMSRHSSGPRRNRDTMMSLLKTVVIVLGAFII 269
Cdd:cd15134 160 FcamlneippitpVFQLstfLFFIIPMIAIIVLYVLIGLQLRRSTLlrRGQRSVSGGRRSSQSRRTVLRMLVAVVVAFFI 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1857425  270 CWTPGLVLLLLDVCCPQcDVLAYEKFFLLLAE-------FNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15134 240 CWAPFHAQRLLTVYAKN-MTPPYLFINRILFYisgvlyyVSSTVNPILYNV----MSAKYRQ 296
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
58-311 5.27e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 56.47  E-value: 5.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   58 TVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPN-----TRRLTVSTWLLR--QGLIDT 130
Cdd:cd15196   9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAL------FNVLPQliwdiTYRFYGGDLLCRlvKYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSV-----------GWNCIcdiencSNMA 199
Cdd:cd15196  83 GMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLL-SIPQLfifsyqevgsgVYDCW------ATFE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSDSYLVFW---AIFnLVTFVVMVVLYAHIFGYVRQ---RTMRMsrhssgprrnrdtmmsllkTVVIVLgAFIICWTP 273
Cdd:cd15196 156 PPWGLRAYITWftvAVF-VVPLIILAFCYGRICYVVWRakiKTVKL-------------------TLVVVA-CYIVCWTP 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 1857425  274 GLVLLLLDVCCPQCDvlAYEKFF---LLLAEFNSAMNPIIY 311
Cdd:cd15196 215 FFVVQMWAAWDPTAP--IEGPAFviiMLLASLNSCTNPWIY 253
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
51-322 8.24e-09

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 55.84  E-value: 8.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFimlANLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGpntrrLTVS-TWLLRQGLID 129
Cdd:cd15066   4 FAMTLIILAAIF---GNLLVIISVMRHRKLRVITNYFVVSLAMADML--VALCAMTFNAS-----VEITgRWMFGYFMCD 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 --TSL-----TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP-SVGWNC--------ICDI 192
Cdd:cd15066  74 vwNSLdvyfsTASILHLCCISVDRYYAIVQpLEYPSKMTKRRVAIMLANVWISPALISFLPiFLGWYTteehlqyrKTHP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  193 ENCS---NMAPLYSDSYLVFWaifnlVTFVVMVVLYAHIFgyvrqrTMRMSRHSSGprrnrdtmmsllKTVVIVLGAFII 269
Cdd:cd15066 154 DQCEfvvNKIYALISSSVSFW-----IPCIVMIFTYYRIY------LEAKREHKAA------------KTLGIIMGAFIL 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 1857425  270 CWTPGLV-LLLLDVC---CPQCDVLAYEKFFLllAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15066 211 CWLPFFLwYVTTTLCgdaCPYPPILVSILFWI--GYFNSTLNPLIYAYFNRDFREAF 265
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
57-324 8.52e-09

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 55.83  E-value: 8.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGPNtrrLTVSTWLLRQGLIDT------ 130
Cdd:cd15392   8 STIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDIL--MAVFCVPFSFIAL---LILQYWPFGEFMCPVvnylqa 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 -SLTASVANLLAIAIERHITVFrMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPS-------VGWNCICDIENCSNMAPLY 202
Cdd:cd15392  83 vSVFVSAFTLVAISIDRYVAIM-WPLRPRMTKRQALLLIAVIWIFALAT-ALPIaitsrlfEDSNASCGQYICTESWPSD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  203 SDSYLVFWAIFNLVTFV---VMVVLYAHIfGYV--RQRTMRMSRHSSGPRRNRdTMMSLLKTVVIVLGAFIICWTPGLVL 277
Cdd:cd15392 161 TNRYIYSLVLMILQYFVplaVLVFTYTRI-GIVvwAKRTPGEAENNRDQRMAE-SKRKLVKMMITVVAIFALCWLPLNIL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 1857425  278 LLLDVCCPQCDVLAYEKF----FLLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15392 239 NLVGDHDESIYSWPYIPYlwlaAHWLAMSHCCYNPFIYCW----MNAKFRN 285
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
51-311 1.13e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 55.51  E-value: 1.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGiTVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTWLLRQGLIDT 130
Cdd:cd15050   3 LGIALS-TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPL------NIVYLLESKWILGRPVCLF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SL-------TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCI------------C 190
Cdd:cd15050  76 WLsmdyvasTASIFSLFILCIDRYRSVQQpLKYLKYRTKTRASLMISGAWLLSFLW-VIPILGWHHFarggervvledkC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  191 DIEncsnmapLYSDSYL-VFWAIFNL-VTFVVMVVLYAHIFGYVRqrtmrmsrhssgprRNRDTMmsllKTVVIVLGAFI 268
Cdd:cd15050 155 ETD-------FHDVTWFkVLTAILNFyIPSLLMLWFYAKIFKAVN--------------RERKAA----KQLGFIMAAFI 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 1857425  269 ICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIY 311
Cdd:cd15050 210 LCWIPYFILFMVIAFCKNCCNENLHMFTIWLGYINSTLNPFIY 252
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
55-328 1.23e-08

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 55.61  E-value: 1.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL-----AYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15306   6 LILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLfvmpiALLTILFEAMWPLPLVLCPIWLFLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TsltASVANLLAIAIERHITVFRMQLHTRMSNR-RVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCSNMAPLYSDSYLV 208
Cdd:cd15306  86 T---ASIMHLCAISLDRYIAIKKPIQASQYNSRaTAFIKITVVWLISIGI-AIPVPIKGIETDVDNPNNITCVLTKERFG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  209 FWAIFN-----LVTFVVMVVLYAHIFGYVRQRTMRMSRHSSgprrnrdtmmsllKTVVIVLGAFIICWTPGLVLLLLDVC 283
Cdd:cd15306 162 DFILFGslaafFTPLAIMIVTYFLTIHALRKQTITNEQRAS-------------KVLGIVFFLFLLMWCPFFITNITSVL 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 1857425  284 CPQCDVLAYEKF---FLLLAEFNSAMNPIIYSYRDKEMSATFRQILCC 328
Cdd:cd15306 229 CDSCNQTTLQMLmeiFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
58-322 1.62e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 55.03  E-value: 1.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   58 TVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWLLRQGLIDTSLT---- 133
Cdd:cd15298   9 SLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGA------FSMNLYTVYIIKGYWPLGAVVCDLWLAldyv 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ---ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI----------CDIENCSNMA 199
Cdd:cd15298  83 vsnASVMNLLIISFDRYFCVTKpLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVvgkrtvpdnqCFIQFLSNPA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSDSYLVFWaifnlVTFVVMVVLYAHIfgyvrqrtmrmsrhSSGPRRNRdtmmSLLKTVVIVLGAFIICWTPGLVLLL 279
Cdd:cd15298 163 VTFGTAIAAFY-----LPVVIMTVLYIHI--------------SLASARER----KVTRTIFAILLAFILTWTPYNVMVL 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 1857425  280 LDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15298 220 VNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
61-322 1.73e-08

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 54.94  E-value: 1.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFF-AGLAYFYLMFNTgpntrrlTVSTWLLRQGLIDTSL------- 132
Cdd:cd15323  12 VFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILvATLVMPFSLANE-------LMGYWYFGQVWCNIYLaldvlfc 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDiENCSNMAPLYSDSYLVFWA 211
Cdd:cd15323  85 TSSIVHLCAISLDRYWSVTQaVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPE-GDVYPQCKLNDETWYILSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  212 IFN--LVTFVVMVVLYAHIFGYVRQRTMRMSRhssgprrnrdtmmsllkTVVIVLGAFIICWTPGL-VLLLLDVCCPQCD 288
Cdd:cd15323 164 CIGsfFAPCLIMILVYIRIYRVAKAREKRFTF-----------------VLAVVMGVFVVCWFPFFfSYSLYGICREACE 226
                       250       260       270
                ....*....|....*....|....*....|....*
gi 1857425  289 VL-AYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15323 227 VPePLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
59-322 1.73e-08

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 55.03  E-value: 1.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWLLRQGLIDTSLT----- 133
Cdd:cd15300  10 VSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGI------FSMNLYTSYILMGYWALGSLACDLWLAldyva 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 --ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI----------CDIENCSNMAP 200
Cdd:cd15300  84 snASVMNLLVISFDRYFSITRpLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFvgkrtvpereCQIQFLSEPTI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSDSYLVFWaifnlVTFVVMVVLYAHIFgyvrQRTMRMSRHSsgprrnrdtmmsllKTVVIVLGAFIICWTPGLVLLLL 280
Cdd:cd15300 164 TFGTAIAAFY-----IPVSVMTILYCRIY----KETIKERKAA--------------QTLSAILLAFIITWTPYNIMVLV 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 1857425  281 DVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15300 221 STFCSDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
51-313 1.81e-08

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 54.87  E-value: 1.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFimlANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTWLLRQGL--- 127
Cdd:cd15316   5 IVLGFGAVLAVF---GNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPF------STVRSVESCWYFGESFctf 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 ---IDTSLT-ASVANLLAIAIERHITVFRMQLH-TRMSNRRVVVVIVVIWTMAIVM-GAI------------PSVGWNCI 189
Cdd:cd15316  76 htcCDVSFCyASLFHLCFISVDRYIAVTDPLVYpTKFTVSVSGICISVSWIFSLTYsFSVfytgvnddgleeLVNALNCV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  190 CDIENCSNMAPLYSDSYLVFwaifnlVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLL--------KTVV 261
Cdd:cd15316 156 GGCQIILNQNWVLVDFLLFF------IPTFAMIILYGKIFLVAKQQARKIEMTSSKAESSSESYKDRVarrerkaaKTLG 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 1857425  262 IVLGAFIICWTPGLVLLLLDV----CCPQCdvlAYEkFFLLLAEFNSAMNPIIYSY 313
Cdd:cd15316 230 ITVIAFLVSWLPYLIDVLIDAfmnfITPPY---IYE-ICCWCAYYNSAMNPLIYAL 281
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
55-329 2.20e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 54.57  E-value: 2.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-----LAYFYLMFNTGPNTRRLTVsTWLLRQGLId 129
Cdd:cd15307   6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAvlvmpLGILTLVKGHFPLSSEHCL-TWICLDVLF- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 tsLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIP----------SVGWNCICDIENcsnm 198
Cdd:cd15307  84 --CTASIMHLCTISVDRYLSLrYPMRFGRNKTRRRVTLKIVFVWLLSIAM-SLPlslmyskdhaSVLVNGTCQIPD---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  199 aPLYSdsyLVFWAIFNLVTFVVMVVLYAHIfgyVRQRTMRMSRHSsgprRNRDTMMSLLKTVVIVLGAFIICWTPGLVLL 278
Cdd:cd15307 157 -PVYK---LVGSIVCFYIPLGVMLLTYCLT---VRLLARQRSRHG----RIIRLEQKATKVLGVVFFTFVILWSPFFVLN 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 1857425  279 LLDVCCPQCDV-LAYEKFFLL--LAEFNSAMNPIIYSYRDKEMSATFRQILCCQ 329
Cdd:cd15307 226 LLPTVCAECEErISHWVFDVVtwLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 279
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
57-324 2.29e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 54.67  E-value: 2.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFI--MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFA---GLAY-FYLMFNTGPNTrrLTVSTWLLRQGLIDT 130
Cdd:cd14979   6 IYVAIFVvgIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLIllvGLPVeLYNFWWQYPWA--FGDGGCKLYYFLFEA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCSN---------MAP 200
Cdd:cd14979  84 CTYATVLTIVALSVERYVAIcHPLKAKTLVTKRRVKRFILAIWLVSILC-AIPILFLMGIQYLNGPLPgpvpdsavcTLV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSDSYLVFWAIFNLVTFV----VMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMS--LLKTVVIVLG----AFIIC 270
Cdd:cd14979 163 VDRSTFKYVFQVSTFIFFVlpmfVISILYFRIGVKLRSMRNIKKGTRAQGTRNVELSLSqqARRQVVKMLGavviAFFVC 242
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  271 WTPGLVLLLLDVCCPQCDV---LAYEKFFLL---LAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd14979 243 WLPFHAQRLMFSYASKEDTflfDFYQYLYPIsgiLFYLSSAINPILYNL----MSSRFRV 298
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
61-313 3.75e-08

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 54.10  E-value: 3.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTWLLRQGL------IDTSLT- 133
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPF------STIRSVESCWYFGDSFcrlhtcLDTLFCl 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ASVANLLAIAIERHITVFRMQLH-TRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF--- 209
Cdd:cd15318  86 TSIFHLCFISIDRHCAICDPLLYpSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAELLTSVPCVGSCQLLYnkl 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTF----VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP 285
Cdd:cd15318 166 WGWLNFPVFfipcLIMIGLYVKIFIVAKRQARAIASLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLN 245
                       250       260
                ....*....|....*....|....*...
gi 1857425  286 QCDVLAYEKFFLLLAEFNSAMNPIIYSY 313
Cdd:cd15318 246 FITPPLLFDIIIWFAYFNSACNPLIYVF 273
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
59-324 4.35e-08

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 53.95  E-value: 4.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFP--IYYLMANLAAADFFaglayfYLMFNTGPNTRRLTVSTWLLRQGLIDTS----- 131
Cdd:cd15002   9 ICLLGFAGNLMVIGILLNNARKGKPslIDSLILNLSAADLL------LLLFSVPFRAAAYSKGSWPLGWFVCKTAdwfgh 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 --LTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSV----------GWNCICDIencsnmA 199
Cdd:cd15002  83 acMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIWVPACLL-PLPQWlfrtvkqsegVYLCILCI------P 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGP----RRNRDTMMSLLKTVvivlgAFIICWTPGL 275
Cdd:cd15002 156 PLAHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLrnqiRSRKLTHMLLSVVL-----AFTILWLPEW 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 1857425  276 VLLLLDVCCPQCDVLAYEKFFL---LLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15002 231 VAWLWLIHIKSSGSSPPQLFNVlaqLLAFSISSVNPIIFLL----MSEEFRE 278
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
51-273 5.16e-08

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 53.59  E-value: 5.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFfaGLAYFYLMFNTGPNTRrltvSTWLLRQ----- 125
Cdd:cd15073   2 IVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDL--GVSIIGYPFSAASDLH----GSWKFGYagcqw 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  126 --GLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNC--------ICDIENC 195
Cdd:cd15073  76 yaFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASyaldptgaTCTINWR 155
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1857425  196 SNMAPLYSDSYLVFWAIFnLVTFVVMVVLYAHIFGYVRQRTmrMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP 273
Cdd:cd15073 156 KNDSSFVSYTMSVIVVNF-IVPLAVMFYCYYNVSRFVKKVL--ASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSP 230
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
51-311 7.10e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 53.37  E-value: 7.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLgitVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFylmfntgPNTRRLTVS-TWLLRQGLID 129
Cdd:cd15958   5 LLMAL---IVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVV-------PFGATLVVRgRWLYGSFFCE 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 --TSL-----TASVANLLAIAIERHITV---FRMQlhTRMSNRRVVVVIVVIWTMAIVMGAIP----------SVGWNCI 189
Cdd:cd15958  75 lwTSVdvlcvTASIETLCVIAIDRYLAItspFRYQ--SLLTRARAKGIVCTVWAISALVSFLPimmhwwrdedDQALKCY 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  190 CDIENC---SNMAPLYSDSYLVFWaifnlVTFVVMVVLYAHIFGYVRQRTMRMSR------------HSSGPRRNRDTMM 254
Cdd:cd15958 153 EDPGCCdfvTNRAYAIASSIISFY-----IPLLIMIFVYLRVYREAKKQIKKIDKcegrfhntltglGRKCKRRPSRILA 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1857425  255 ----SLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIY 311
Cdd:cd15958 228 lreqKALKTLGIIMGVFTLCWLPFFLVNVVNVFNRELVPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
57-273 1.10e-07

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 52.61  E-value: 1.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFaglayfyLMFNTGPNTRRLTVS-TWLLRQGLI------- 128
Cdd:cd15203   8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLL-------LCLVSLPFTLIYTLTkNWPFGSILCklvpslq 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DTSLTASVANLLAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWT--------MAIVMGAIPSVGWNCICDIENCSNMAP 200
Cdd:cd15203  81 GVSIFVSTLTLTAIAIDRYQLIVY-PTRPRMSKRHALLIIALIWIlslllslpLAIFQELSDVPIEILPYCGYFCTESWP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 lySDSYLVFWAIFNLVT-----FVVMVVLYAHIFGYVRQR--------TMRMSRHSSGPRRNRDTMMSLLKTVVIvlgaF 267
Cdd:cd15203 160 --SSSSRLIYTISVLVLqfvipLLIISFCYFRISLKLRKRvkkkrgkrTLSSRRRRSELRRKRRTNRLLIAMVVV----F 233

                ....*.
gi 1857425  268 IICWTP 273
Cdd:cd15203 234 AVCWLP 239
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
61-322 1.13e-07

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 52.25  E-value: 1.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFF-AGLAYFYLMFNTgpntrrlTVSTWLLRQGLIDTSL------- 132
Cdd:cd15322  12 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILvATLVIPFSLANE-------VMGYWYFGKVWCEIYLaldvlfc 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN--------CICDIENcsnmaplyS 203
Cdd:cd15322  85 TSSIVHLCAISLDRYWSITQaIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEkksgqpegPICKIND--------E 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  204 DSYLVFWAIFN-LVTFVVMVVLYAHIFGYVRQRTMRMSRhssgprrnrdtmmsllkTVVIVLGAFIICWTPGLVLLLLDV 282
Cdd:cd15322 157 KWYIISSCIGSfFAPCLIMVLVYIRIYQIAKNREKRFTF-----------------VLAVVIGVFVICWFPFFFTYTLTA 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 1857425  283 CCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15322 220 VCDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
51-324 1.45e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 52.13  E-value: 1.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMfntgpnTRRLTVSTWLLRQGLIDT 130
Cdd:cd15301   2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLF------TVYTALGYWPLGYEVCDT 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SL-------TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-----CDIENCSn 197
Cdd:cd15301  76 WLaidylasNASVLNLLIISFDRYFSVTRpLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPYIegkrtVPAGTCY- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  198 MAPLYSDSYLVF---WAIFnLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSgprrnrdtmmsllKTVVIVLGAFIICWTPG 274
Cdd:cd15301 155 IQFLETNPYVTFgtaLAAF-YVPVTIMCILYWRIWRETKKRQKKQESKAA-------------KTLSAILLAFIVTWTPY 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 1857425  275 LVLLLLDVCCPQCDVLAYE--KFFLLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15301 221 NVLVLIKAFFPCSDTIPTElwDFSYYLCYINSTINPLCYAL----CNAAFRR 268
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
52-273 1.46e-07

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 52.06  E-value: 1.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   52 VMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTgpNTRRLTVSTWLLRQGLIDTS 131
Cdd:cd15905   1 IFWLSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGVALPFIPGMS--NESRRGYHSCLFVYVAPNFL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 LTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNM-----APLYSDS 205
Cdd:cd15905  79 FLSFLANLLMVHYERYLCIVYpLQYHNFWVHRWVPLALLLTWALPLLFACLPALGWNNWTPGSNCSYKqvfpaAYIYLEV 158
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1857425  206 Y-LVFWAIFNLVTFVVMVVLYAHifgyvRQ-----RTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP 273
Cdd:cd15905 159 YgLVLPSILAIAFMSVRVLAVAR-----RQlqdicKLLRAVQRDGPSELEQQLNLRYAKCIAGVSLTFLVCWVP 227
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
47-273 1.58e-07

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 52.03  E-value: 1.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   47 TVSKLVMGLGITVcifiMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRrltvstWLLrqG 126
Cdd:cd15336   2 TVGSVILIIGITG----MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKR------WIF--G 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 LIDTSLTA---------SVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI------- 189
Cdd:cd15336  70 EKGCELYAfcgalfgitSMITLLAISLDRYLVITKpLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYvpegllt 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  190 -CDIENCSNMAPLYSDSYLVFWAIFnLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRN-------RDTMMSLLKTVV 261
Cdd:cd15336 150 sCTWDYMTFTPSVRAYTMLLFCFVF-FIPLGIIIYCYLFIFLAIRSTGREVQKLGSQDRKEkakqyqrMKNEWKMAKIAF 228
                       250
                ....*....|..
gi 1857425  262 IVLGAFIICWTP 273
Cdd:cd15336 229 VVILLFVLSWSP 240
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
55-322 1.79e-07

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 51.86  E-value: 1.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-----LAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGflvmpVSMLTILYGYRWPLPSKLCAVWIYLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TsltASVANLLAIAIERHITVFRMQLHTRMSNR-RVVVVIVVIWTMAI-VMGAIPSVGWNCICDI---ENCSnmapLYSD 204
Cdd:cd15304  86 T---ASIMHLCAISLDRYIAIRNPIHHSRFNSRtKAFLKIIAVWTISVgISMPIPVFGLQDDSKVfkeGSCL----LADE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  205 SYLV---FWAIFnlVTFVVMVVLYAHIFGYVRQRTMRMSRHSsgprrnrdtmmsllKTVVIVLGAFIICWTPGLVLLLLD 281
Cdd:cd15304 159 NFVLigsFVAFF--IPLTIMVITYFLTIKSLQQSISNEQKAS--------------KVLGIVFFLFVVMWCPFFITNVMA 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 1857425  282 VCC-PQCD---VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15304 223 VICkESCNevvIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
60-326 1.81e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 51.88  E-value: 1.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   60 CIFI--MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA-----YFYLMFNTGPNTRRL-TVSTWLLRqglidTS 131
Cdd:cd14982   9 LIFIlgLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTlpfriYYYLNGGWWPFGDFLcRLTGLLFY-----IN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 LTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVmGAIPSVGWNCICDIENCSNMAPLYSDSYLVFW 210
Cdd:cd14982  84 MYGSILFLTCISVDRYLAVVHpLKSRRLRRKRYAVGVCAGVWILVLV-ASVPLLLLRSTIAKENNSTTCFEFLSEWLASA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  211 AIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP--------GLVLLLLDV 282
Cdd:cd14982 163 APIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPyhvtrilyLLVRLSFIA 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 1857425  283 CCPQCDVL--AYEkFFLLLAEFNSAMNPIIYSYrdkeMSATFRQIL 326
Cdd:cd14982 243 DCSARNSLykAYR-ITLCLASLNSCLDPLIYYF----LSKTFRKRL 283
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
59-322 2.55e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 51.46  E-value: 2.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTWLLRQGLID-------TS 131
Cdd:cd15335  10 ITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPL------SITYIVMDTWTLGYFICEiwlsvdmTC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 LTASVANLLAIAIERHITVFRMQLHTRM-SNRRVVVVIVVIWTMAIVMgAIPSVGWN--------CICDIENCSNMAPLY 202
Cdd:cd15335  84 CTCSILHLCVIALDRYWAITDAIEYARKrTAKRAGLMILTVWTISIFI-SIPPLFWRnhhdanipSQCIIQHDHVIYTIY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  203 SdsylVFWAIFnlVTFVVMVVLYAHIFgyvrqrtmrmsrHSSGPRRNRDTMMSLlktvviVLGAFIICWTP---GLVLLL 279
Cdd:cd15335 163 S----TFGAFY--IPLTLILILYYRIY------------HAASRERKAARILGL------ILGAFILSWLPffiKELIVG 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 1857425  280 LDVCCPQCDVlayEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15335 219 LSVMTVSPEV---ADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
59-324 2.67e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 51.16  E-value: 2.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTgpntrRLTVSTWLLRQGLIDTSL------ 132
Cdd:cd15052  10 LVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILT-----ELFGGVWPLPLVLCLLWVtldvlf 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 -TASVANLLAIAIERHITVfRMQLHTRMSNRRVVVVI--VVIWTMAIVM-GAIPSVGwncICDIENCSN--MAPLYSDSY 206
Cdd:cd15052  85 cTASIMHLCTISLDRYMAI-RYPLRTRRNKSRTTVFLkiAIVWLISIGIsSPIPVLG---IIDTTNVLNngTCVLFNPNF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 LVFWAIFN-LVTFVVMVVLYAhifgyvrqRTMRMSRhssgpRRNRDTmmsllKTVVIVLGAFIICWTPGLVLLLLDVCCP 285
Cdd:cd15052 161 VIYGSIVAfFIPLLIMVVTYA--------LTIRLLS-----NEQKAS-----KVLGIVFAVFVICWCPFFITNILTGLCE 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 1857425  286 QCDVLAYEKF---FLLLAEFNSAMNPIIYSYRDKemsaTFRQ 324
Cdd:cd15052 223 ECNCRISPWLlsvFVWLGYVSSTINPIIYTIFNK----TFRR 260
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
57-324 3.01e-07

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 51.23  E-value: 3.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAAD--FFAGL----AYFYLMFN--TGPNTRRLTvstwllrQGLI 128
Cdd:cd14985   8 IAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADlvFVLTLplwaTYTANQYDwpFGAFLCKVS-------SYVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVI-VVIWTMAIVMGaIPSVGWNCICDIE--NCSNMAPLYSDS 205
Cdd:cd14985  81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTcALIWVVACLLS-LPTFLLRSLQAIEnlNKTACIMLYPHE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  206 YLVF-WAIF-NLVTFVV----MVVLYAHIfgyvrQRTMRMsrHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLL 279
Cdd:cd14985 160 AWHFgLSLElNILGFVLplliILTCYFHI-----ARSLRK--RYERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKF 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 1857425  280 LDVC--------CPQCDVLAYE-KFFLLLAEFNSAMNPIIYSYRDKemsaTFRQ 324
Cdd:cd14985 233 LDFLaqlgairpCFWELFLDLGlPIATCLAFTNSCLNPFIYVFVDR----RFRQ 282
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
55-328 4.05e-07

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 50.67  E-value: 4.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL-----AYFYLMFNTGPNTRRLTVSTWLLRQGLID 129
Cdd:cd15305   6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGIlvmpvSLIAILYDYAWPLPRYLCPIWISLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TsltASVANLLAIAIERHITVFRMQLHTRMSNR-RVVVVIVVIWTMAI-VMGAIPSVGW--------NCICdIENCSNMA 199
Cdd:cd15305  86 T---ASIMHLCAISLDRYVAIRNPIEHSRFNSRtKAMMKIAAVWTISIgISMPIPVIGLqddekvfvNGTC-VLNDENFV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSdsylvFWAIFnlVTFVVMVVLYA-HIFGYVRQRTMRMSRHSSgprrnrdtmmsllKTVVIVLGAFIICWTPGLVLL 278
Cdd:cd15305 162 LIGS-----FVAFF--IPLIIMVITYClTIQVLQRQQAINNERRAS-------------KVLGIVFFLFLIMWCPFFITN 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 1857425  279 LLDVCCPQ-CDVLAYEKF---FLLLAEFNSAMNPIIYSYRDKEMSATFRQILCC 328
Cdd:cd15305 222 ILSVLCKEaCDQKLMEELlnvFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
51-273 4.44e-07

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 50.80  E-value: 4.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFImLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWLLRQGL--- 127
Cdd:cd15389   3 LIVAYSIIIVISL-FGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITL------LNTPFTLVRFVNSTWVFGKIMchl 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 ----IDTSLTASVANLLAIAIERHiTVFRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCSNMA---- 199
Cdd:cd15389  76 srfaQYCSVYVSTLTLTAIALDRH-RVILHPLKPRITPCQGVVVIAIIWIMASCL-SLPHAIYQKLVEFEYSNERTrsrc 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 -PLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRM--SRHSSGP---------RRNRDTMMSLLKTVVIVlgaF 267
Cdd:cd15389 154 lPSFPEPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKlwLRNAIGDvtteqyvaqRRKKKKTIKMLMLVVLL---F 230

                ....*.
gi 1857425  268 IICWTP 273
Cdd:cd15389 231 AICWLP 236
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
57-311 6.10e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 50.32  E-value: 6.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHF--PIYYLMANLAAADFFAGLAYFYLMFNTGPNTRrltvsTWLLRQGLID-TSLT 133
Cdd:cd14981   8 ALMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLAVYASNF-----EWDGGQPLCDyFGFM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ASVANL------LAIAIERHITVFRMQLH-TRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN----------CICDIENCS 196
Cdd:cd14981  83 MSFFGLssllivCAMAVERFLAITHPFFYnSHVKKRRARLMLGAVWAFALLIASLPLLGLGsyvlqypgtwCFLDFYSKN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  197 NMAPLYSDSYLVFWAIFNLVTFVV-MVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDT-MMSLLKTVVIVlgaFIICWTPG 274
Cdd:cd14981 163 TGDAAYAYLYSILGLLILLVTLLCnLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIqMVVLLLAITVV---FSVCWLPL 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 1857425  275 LVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIY 311
Cdd:cd14981 240 MIRVLINATGDSEKNGKTDLLAVRMASWNQILDPWVY 276
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
55-325 6.34e-07

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 50.51  E-value: 6.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFIMLA---NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTW-------LLR 124
Cdd:cd14992   3 LGVALVVIILVSvvgNFIVIAALARHKNLRGATNYFIASLAISDLLMAL------FCTPFNFTYVVSLSWeyghflcKIV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  125 QGLIDTSLTASVANLLAIAIERHI-TVFRMQLHTRMSNRRVVVVIVVIWTMAIvMGAIPSVGW--------NCICDIENC 195
Cdd:cd14992  77 NYLRTVSVYASSLTLTAIAFDRYFaIIHPLKPRHRQSYTTTVIIIITIWVVSL-LLAIPQLYYattevlfsVKNQEKIFC 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  196 SNMAPLYSDSYLVFWAIFNLV-----TFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIIC 270
Cdd:cd14992 156 CQIPPVDNKTYEKVYFLLIFVvifvlPLIVMTLAYARISRELWFRKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVIC 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1857425  271 WTPglvLLLLDVCCPQCDVLAYEKFFLL-------LAEFNSAMNPIIYSYrdkeMSATFRQI 325
Cdd:cd14992 236 WLP---FHLFFLLRDFFPLIMKEKHTLQvyyflhwIAMSNSMYNPIIYVT----LNNNFRKN 290
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
45-326 8.08e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 50.18  E-value: 8.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   45 WNTvsKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLR 124
Cdd:cd15082  11 WNF--TVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  125 QGLIDTSL-TASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAP-LY 202
Cdd:cd15082  89 EGFAVTFFgIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPnWY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  203 SDSY------LVFWAIFNLVTFVVMVVLYahifGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLV 276
Cdd:cd15082 169 SGNMhdhtyiITFFTTCFILPLGVIFVSY----GKLLQKLRKVSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAA 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 1857425  277 LLLLDVCCPQCDV----LAYEKFFlllAEFNSAMNPIIYSYRDKEmsatFRQIL 326
Cdd:cd15082 245 FSILVTAHPTIHLdprlAAIPAFF---SKTAAVYNPIIYVFMNKQ----FRKCL 291
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
59-324 1.03e-06

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 49.60  E-value: 1.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFaglayfYLMFNTGPNTRRLTVSTWLL-------RQGLIDTS 131
Cdd:cd15096  10 IFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLL------FVVFCVPFTATDYVLPTWPFgdvwckiVQYLVYVT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 LTASVANLLAIAIERHITVFR----MQLHTRmsnRRVVVVIVVIWTMaIVMGAIP-------SVGWNCICDIENCsNMAP 200
Cdd:cd15096  84 AYASVYTLVLMSLDRYLAVVHpitsMSIRTE---RNTLIAIVGIWIV-ILVANIPvlflhgvVSYGFSSEAYSYC-TFLT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSDSYLVFWAIFNLVTFV----VMVVLYAHIFGYVRQRTMRMSRHS--SGPRRNRDTMMsllktVVIVLGAFIICWTPG 274
Cdd:cd15096 159 EVGTAAQTFFTSFFLFSYLipltLICVLYMLMLRRLRRQKSPGGRRSaeSQRGKRRVTRL-----VVVVVVVFAICWLPI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 1857425  275 LVLLLLDVCCPQCDVLAYEKFFLL---LAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15096 234 HIILLLKYYGVLPETVLYVVIQILsncLAYGNSCVNPILYAF----LSQNFRK 282
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
52-273 1.14e-06

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 49.63  E-value: 1.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   52 VMGLGITVC-IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADF-FAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLId 129
Cdd:cd15337   2 LIGIYIAIVgILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFgFSAVNGFPLKTISSFNKKWIWGKVACELYGFA- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTA--SVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW--------NCICDIENCSNM 198
Cdd:cd15337  81 GGIFGfmSITTLAAISIDRYLVIAKpLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWgryvpegfQTSCTFDYLSRD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  199 APlySDSYLVFWAIFNLVT-FVVMVVLYAHIFGYVR--QRTMR------MSRHSSGPRRNRDTMMSLLKTVVIVLGAFII 269
Cdd:cd15337 161 LN--NRLFILGLFIFGFLCpLLIIIFCYVNIIRAVRnhEKEMTqtaksgMGKDTEKNDARKKAEIRIAKVAIILISLFLL 238

                ....
gi 1857425  270 CWTP 273
Cdd:cd15337 239 SWTP 242
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
61-313 1.36e-06

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 49.16  E-value: 1.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIM--LANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayFYLMFNT----------GPNTRRLTvstwLLRQGLi 128
Cdd:cd15207  10 IFLLcvVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGV--FCMPFTLvdniltgwpfGDVMCKLS----PLVQGV- 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 dtSLTASVANLLAIAIERHITVfrmqLH---TRMSNRRVVVVIVVIWTMAIVMGaIPSV--------GWNCICDIENCSN 197
Cdd:cd15207  83 --SVAASVFTLVAIAVDRYRAV----VHptePKLTNRQAFVIIVAIWVLALAIM-IPQAlvlevkeyQFFRGQTVHICVE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  198 MAP------LYSDSYLVFWAIFNLVtfvVMVVLYAHIFGYVRQRTMRMSRHSSGPRR-----NRDTMMSLLKTVVIVlga 266
Cdd:cd15207 156 FWPsdeyrkAYTTSLFVLCYVAPLL---IIAVLYVRIGYRLWFKPVPGGGSASREAQaavskKKVRVIKMLIVVVVL--- 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 1857425  267 FIICWTPGLVLLLLDVCC----PQCDVLAYEKFFL--LLAEFNSAMNPIIYSY 313
Cdd:cd15207 230 FALSWLPLHTVTMLDDFGnlspNQREVLYVYIYPIahWLAYFNSCVNPIVYGY 282
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
57-322 1.44e-06

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 48.88  E-value: 1.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIF-IMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFF-AGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA 134
Cdd:cd15309   7 LTLLIFvIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLvATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  135 SVANLLAIAIERHITV-FRMQLHTRMSN-RRVVVVIVVIWTMAIVMGAIPSVGWNcicdiENCSNMAPLYSDSYLVFWAI 212
Cdd:cd15309  87 SILNLCAISIDRYTAVaMPMLYNTRYSSkRRVTVMISVVWVLSFAISCPLLFGLN-----NTDQNECIIANPAFVVYSSI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  213 FNL-VTFVVMVVLYAHIFGYVRqrtmrmsrhssgpRRNRDTMMsllktVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLA 291
Cdd:cd15309 162 VSFyVPFIVTLLVYVQIYIVLQ-------------KEKKATQM-----LAIVLGVFIICWLPFFITHILNMHCDCNIPPA 223
                       250       260       270
                ....*....|....*....|....*....|.
gi 1857425  292 YEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15309 224 LYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
67-273 1.57e-06

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 49.06  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   67 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTsLTASVA--NLLAIAI 144
Cdd:cd15080  18 NFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFAT-LGGEIAlwSLVVLAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  145 ERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN--------CICDIENCSNMAPLYSDSYLVFWAIFN-L 215
Cdd:cd15080  97 ERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSryipegmqCSCGIDYYTLKPEVNNESFVIYMFVVHfT 176
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1857425  216 VTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDtmmsLLKTVVIVLGAFIICWTP 273
Cdd:cd15080 177 IPLIVIFFCYGRLVCTVKEAAAQQQESATTQKAEKE----VTRMVIIMVIAFLICWVP 230
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
58-311 2.03e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 48.91  E-value: 2.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   58 TVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA------YFYLMFN-TGPNT-----RRLTVSTwllrq 125
Cdd:cd14986   9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFtvltqiIWEATGEwVAGDVlcrivKYLQVVG----- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  126 glidtsLTASVANLLAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGwncICDIENCSNMAPL---- 201
Cdd:cd14986  84 ------LFASTYILVSMSLDRYQAIVK-PMSSLKPRKRARLMIVVAWVLSFLF-SIPQLV---IFVERELGDGVHQcwss 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  202 -YSDSYL---VFWAIFNL--VTFVVMVVLYAHIFGYVRQR-----------TMRMSRHSSGPRRNRDTMM-----SLLKT 259
Cdd:cd14986 153 fYTPWQRkvyITWLATYVfvIPLIILSYCYGRILRTIWIRsrqktdrpiapTAMSCRSVSCVSSRVSLISrakikTIKMT 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 1857425  260 VVIVLgAFIICWTPGLVLLLLDV--CCPQCDVLAYEKFFlLLAEFNSAMNPIIY 311
Cdd:cd14986 233 LVIIL-AFILCWTPYFIVQLLDVyaGMQQLENDAYVVSE-TLASLNSALNPLIY 284
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
133-324 2.30e-06

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 48.85  E-value: 2.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 TASVANLLAIAIERHITV---FRMQlhTRMSNRRVVVVIVVIWTMAIVMGAIP-SVGWNCI--------------CDIEN 194
Cdd:cd15320  86 TASILNLCVISVDRYWAIsspFRYE--RKMTPKVAFIMISVAWTLSVLISFIPvQLNWHKAkptsfldlnaslrdLTMDN 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  195 C-SNMAPLY--SDSYLVFWaifnlVTFVVMVVLYAHIFGYVRQRTMRMS------------RHSSGPRRNRDTM------ 253
Cdd:cd15320 164 CdSSLNRTYaiSSSLISFY-----IPVAIMIVTYTRIYRIAQKQIRRISaleraavhakncQNSTGNRGSGDCQqpessf 238
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  254 -------MSLLKTVVIVLGAFIICWTPglvLLLLDVCCPQCDVLAYEKF---------FLLLAEFNSAMNPIIYSYrdke 317
Cdd:cd15320 239 kmsfkreTKVLKTLSVIMGVFVCCWLP---FFILNCMVPFCKPTSTEPFcissttfdvFVWFGWANSSLNPIIYAF---- 311

                ....*..
gi 1857425  318 mSATFRQ 324
Cdd:cd15320 312 -NADFRK 317
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
64-311 2.93e-06

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 48.25  E-value: 2.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   64 MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGlAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSL--TASVANLLA 141
Cdd:cd15296  15 VLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVG-GFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLlcTASVFNIVL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  142 IAIERHITVFRMQLHTRMSN--RRVVVVIVVIWTMAIVMGAIPSVGWNCI----------CDIENCSNMAPLYSDSYLVF 209
Cdd:cd15296  94 ISYDRFLSVTRAVSYRAQKGmtRQAVLKMVLVWVLAFLLYGPAIISWEYIaggsiipegeCYAEFFYNWYFLMTASTLEF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  210 WAIFNLVTFVVMvvlyaHIFGYVRQRTMRMSRHSsgprrnrdtmmSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP-QC- 287
Cdd:cd15296 174 FTPFISVTYFNL-----SIYLNIQKRRFRLSRDK-----------KVAKSLAIIVCVFGLCWAPYTLLMIIRAACHgHCv 237
                       250       260
                ....*....|....*....|....*
gi 1857425  288 -DVLaYEKFFLLLAeFNSAMNPIIY 311
Cdd:cd15296 238 pDYW-YETSFWLLW-VNSAINPVLY 260
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
59-326 4.85e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 47.44  E-value: 4.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFImlANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGlayfylMFNTGPNTRRLTVSTWL-------LRQGLIDTS 131
Cdd:cd15012  11 CCCFF--GNLLVILVVTSHRRMRTITNFFLANLAVADLCVG------IFCVLQNLSIYLIPSWPfgevlcrMYQFVHSLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 LTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGA--------IPSVGWNCICDIENC-----SN 197
Cdd:cd15012  83 YTASIGILVVISVERYIAILHpLRCKQLLTAARLRVTIVTVWLTSAVYNTpyfvfsqtVEILVTQDGQEEEICvldreMF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  198 MAPLYSDSYLVFWAifnLVTFVVMVVLYAHIfGYVrqrtmrMSRHSSGPRRNRdtmmsLLKTVVIVLGAFIICWTPGLVL 277
Cdd:cd15012 163 NSKLYDTINFIVWY---LIPLLIMTVLYSKI-SIV------LWKSSSIEARRK-----VVRLLVAVVVSFALCNLPYHAR 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 1857425  278 LLLDV-----CCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYrdkeMSATFRQIL 326
Cdd:cd15012 228 KMWQYwsepyRCDSNWNALLTPLTFLVLYFNSAVNPLLYAF----LSKRFRQSM 277
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
64-326 5.26e-06

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 47.51  E-value: 5.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   64 MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL-----AYFYLMFNTGPNTRRLTVSTWLLRQglidTSLTASVAN 138
Cdd:cd15391  15 VGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALfcmpfTFTQIMLGHWVFPAPMCPIVLYVQL----VSVTASVLT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  139 LLAIAIERHITVFrMQLHTRMSNRRVVVVIVVIWTMAIVMGAI------PSVGWNCICDIENCSNMAPLYSDSYLVFWAI 212
Cdd:cd15391  91 NTAIGIDRFFAVI-FPLRSRHTKSRTKCIIASIWAISFSLSSVqlfagrTQRYGQYSEGRVLCGESWPGPDTSRSAYTVF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  213 FNLVTFVVMVVLYAHIFGYVR----QRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP-GLVLLLLDVC---- 283
Cdd:cd15391 170 VMLLTYIIPLLILTSTYGYVGfrlwNRTAPGNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPlHLFNLVQDFStvfr 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 1857425  284 -CPQCDVLAYEKFFLLLAEFNSAMNPIIYSYrdkeMSATFRQIL 326
Cdd:cd15391 250 nMPQHTTRLIYGACHWIAMSNSFVNPIIYLF----MNDSFRSIL 289
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
55-322 6.84e-06

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 46.79  E-value: 6.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGITVCIFI-MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSL- 132
Cdd:cd15324   5 LVVVVIILVtIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFc 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSV-----GWNCIcdiencsnmapLYSDSY 206
Cdd:cd15324  85 TSSIVHLCAISLDRYWSVTKaVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLmtkhdEWECL-----------LNDETW 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 LVFWAIfnLVTF----VVMVVLYAHIFGYVRQRTMRMSRhssgprrnrdtmmsllkTVVIVLGAFIICWTPGLVLLLLD- 281
Cdd:cd15324 154 YILSSC--TVSFfapgLIMILVYCKIYRVAKMREKRFTF-----------------VLAVVMGVFVLCWFPFFFTYSLHa 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 1857425  282 VCCPQCDVL-AYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15324 215 VCRKRCGIPdALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
139-313 8.55e-06

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 46.92  E-value: 8.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  139 LLAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN-----CICDIENCSNMAPLYSDSYLVFWAIF 213
Cdd:cd15382  92 LVCISLDRYFAILK-PLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFHveshpCVTWFSQCVTFNFFPSHDHELAYNIF 170
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  214 NLVT-----FVVMVVLYAHIFGYVRQRTMR----MSRHSSGPRRNRDTMMSL-------LK-TVVIVLgAFIICWTPGLV 276
Cdd:cd15382 171 NMITmyalpLIIIVFCYSLILCEISRKSKEkkedVSEKSSSVRLRRSSVGLLerarsrtLKmTIVIVL-VFIICWTPYFI 249
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 1857425  277 LLLLDVCCPQCDVL---AYEKFFLLLAEFNSAMNPIIYSY 313
Cdd:cd15382 250 MSLWYWFDRESASKvdpRIQKGLFLFAVSNSCMNPIVYGY 289
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
59-324 9.59e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 46.90  E-value: 9.59e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIML----ANLLVMVAIYVNRRFHFPIYYLMANLAAADFF-------AGLAYFYlmfntgpntrrlTVSTWLLRQ-- 125
Cdd:cd14997   6 VYGVIFVvgvlGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLvllvcmpVALVETW------------AREPWLLGEfm 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  126 ----GLIDTSLT-ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIV----MGAIP--------SVGWN 187
Cdd:cd14997  74 cklvPFVELTVAhASVLTILAISFERYYAICHpLQAKYVCTKRRALVIIALIWLLALLtsspVLFITefkeedfnDGTPV 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  188 CICDIENCSNMAPLYsdsYLVFWAIFNLVTFVVMVVLYA----HIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIV 263
Cdd:cd14997 154 AVCRTPADTFWKVAY---ILSTIVVFFVVPLAILSGLYSvicrRLVGHPALESRRADAANRHTLRSRRQVVYMLITVVVL 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1857425  264 lgaFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLL--------LAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd14997 231 ---FFVCLLPFRVVTLWIIFAPDEDLQALGLEGYLnllvfcrvMVYLNSALNPILYNL----MSTKFRS 292
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
57-273 1.09e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 46.47  E-value: 1.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGPNTRRLTV--STWLLRQGLIDTSLT- 133
Cdd:cd15214   7 IIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLL--LSVLVLPFVVTSSIRREWIfgVVWCNFSALLYLLISs 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-CDIENCSNMAPLYSD-SYLVFW 210
Cdd:cd15214  85 ASMLTLGAIAIDRYYAVlYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLeFDRFKWMCVAAWHKEaGYTAFW 164
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1857425  211 AIF-NLVTFVVMVVLYAHIFgyvrqrtmrmsrhssgpRRNRDTMMSLLKTVVIVLGAFIICWTP 273
Cdd:cd15214 165 QVWcALLPFVVMLVCYGFIF-----------------RVARANQCKAFITILVVLGAFVTTWGP 211
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
61-322 1.17e-05

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 46.40  E-value: 1.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLaYFYLMFNTGPNTRRLTVS---TWLLRQGLIDT------S 131
Cdd:cd15359  12 ILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGL-YLLLIASVDSQTKSQYYNhaiDWQTGSGCSTAgfftvfA 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 LTASVANLLAIAIER-HITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNM--APLYSDSYLV 208
Cdd:cd15359  91 SELSVYTLTVITLERwHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMdiETLLSQAYIL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  209 FWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSrhssgprrNRDTMMSllKTVVIVLGAFIICWTP-GLVLLLLDVCCPQC 287
Cdd:cd15359 171 LILVLNVIAFLVICACYIKIYLAVQNPELVAK--------NKDTKIA--KRMAILIFTDFTCMAPiSFFAISAAFKVPLI 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 1857425  288 DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15359 241 TVTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
67-324 1.18e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 46.52  E-value: 1.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   67 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWL-------LRQGLIDTSLTASVANL 139
Cdd:cd15390  18 NLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISA------FNTVFNFTYLLYNDWPfglfyckFSNFVAITTVAASVFTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  140 LAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSV-------------GWNCICDIENCSNMAPLYSDSY 206
Cdd:cd15390  92 MAISIDRYIAIVH-PLRPRLSRRTTKIAIAVIWLASFLL-ALPQLlysttetyyyytgSERTVCFIAWPDGPNSLQDFVY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 -LVFWAIFNLVTFVVMVVLYAHIfGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP 285
Cdd:cd15390 170 nIVLFVVTYFLPLIIMAVAYTRV-GVELWGSKTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPYHLYFILTYLYP 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 1857425  286 QcdvLAYEKF-------FLLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15390 249 D---INSWKYiqqiylaIYWLAMSNSMYNPIIYCW----MNKRFRY 287
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
57-316 1.59e-05

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 45.95  E-value: 1.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGpNTRRLTVSTWLLR--QGLIDTSLTA 134
Cdd:cd15380   8 IAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIR-NQFNWPFGNFLCRviSGVIKANLFI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  135 SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVI-VVIWTMAIVMgAIPSVGWNCI-----CDIENCSNMAPlYSDSYLV 208
Cdd:cd15380  87 SIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVIcLLIWVFGGLL-SIPTFLFRSVkhvpdLNISACILLFP-HEAWHFA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  209 FWAIFNLVTF----VVMVVLYAHIFGYVRQRTmRMSRHSSGPRRNRDTmMSLLKTVVIVlgaFIICWTPGLVLLLLDV-- 282
Cdd:cd15380 165 RRVELNIVGFllplAAIVFFNFHIIASLRERT-EESRKRCGGLKDTKA-TRLILTLVLM---FLVCWTPYHFFAFLDFlf 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 1857425  283 ---CCPQCDVLAYEKFFLLLAEF----NSAMNPIIYSYRDK 316
Cdd:cd15380 240 qveVIQGCFWEEFIDLGLQLANFfafaNSCLNPVIYVFAGK 280
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
130-273 2.22e-05

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 45.73  E-value: 2.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHItVFRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCSNM----------A 199
Cdd:cd15204  84 VSLYVSTNALLVIAIDRYL-VIVHPLKPRMKRRTACVVIALVWVVSLLL-AIPSAVYSKTTPYANQGKIfcgqiwpvdqQ 161
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1857425  200 PLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTM---RMSRHSSGPRRNRDTMMSLlktvVIVLGAFIICWTP 273
Cdd:cd15204 162 AYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVpgqQTEQIRRRLRRRRRKVRLL----VVILTAFVLCWAP 234
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
59-311 2.23e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 45.57  E-value: 2.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIML---ANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFylmfntGPNTRRLTVSTWLLRQGL------ID 129
Cdd:cd15054   7 LCLIILLtvaGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVM------PPAMLNALYGRWVLARDFcpiwyaFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSL-TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP-SVGWNCICDIENCSNMA--PLYSD 204
Cdd:cd15054  81 VMCcSASILNLCVISLDRYLLIISpLRYKLRMTPPRALALILAAWTLAALASFLPiELGWHELGHERTLPNLTsgTVEGQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  205 SYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSsgprrnrdtmMSLLKTVVIVLGAFIICWTPglvLLLLDVCC 284
Cdd:cd15054 161 CRLLVSLPYALVASCLTFFLPSGAICFTYCRILLAARKA----------LKASLTLGILLGMFFVTWLP---FFVANVVQ 227
                       250       260
                ....*....|....*....|....*....
gi 1857425  285 PQCDVLAYEKFFLL--LAEFNSAMNPIIY 311
Cdd:cd15054 228 AVCDCVSPGLFDVLtwLGYCNSTMNPIIY 256
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
53-311 2.39e-05

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 45.62  E-value: 2.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   53 MGLGITVCIFIM---LANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTWLLRQGLID 129
Cdd:cd15957   1 VGMGIVMSLIVLaivFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPF------GAAHILLKTWTFGNFWCE 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 --TSL-----TASVANLLAIAIERHITV---FRMQlhTRMSNRRVVVVIVVIWTMAIVMGAIP-SVGW---------NCI 189
Cdd:cd15957  75 fwTSIdvlcvTASIETLCVIAVDRYFAItspFKYQ--SLLTKNKARVIILMVWIVSGLTSFLPiQMHWyrathqeaiNCY 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  190 CDIENC---SNMAPLYSDSYLVFWaifnlVTFVVMVVLYAHIFGYVRQRTMRMSR--------------HSSGPRRNRDT 252
Cdd:cd15957 153 AEETCCdffTNQAYAIASSIVSFY-----VPLVIMVFVYSRVFQEAKRQLQKIDKsegrfhnqnidqngSGGGGGNRRRS 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1857425  253 MMSL-----LKTVVIVLGAFIICWTPGLVLLLLDVCcpQCDVLAYEKFFLL--LAEFNSAMNPIIY 311
Cdd:cd15957 228 KFCLkehkaLKTLGIIMGTFTLCWLPFFIVNIVHVI--QDNLIRKEVYILLnwIGYVNSGFNPLIY 291
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
69-324 2.88e-05

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 45.23  E-value: 2.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   69 LVMVAIYVNRRFHFPI-YYLMANLAAADFFAGLaYFYLMFNTGPNTRRLTVS---TWLLRQGLIDTSLTA------SVAN 138
Cdd:cd15360  19 IVVLAILLTSQYKLTVpRFLMCNLAFADLCMGI-YLLLIASVDIRTKSQYYNyaiDWQTGAGCAAAGFFTvfaselSVYT 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  139 LLAIAIER-HITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNM---APLySDSYLVFWAIFN 214
Cdd:cd15360  98 LTVITLERwHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMdieSPL-SQAYIIFILVLN 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  215 LVTFVVMVVLYAHIFGYVRQRTMRMSrhssgprrNRDTMMSllKTVVIVLGAFIICWTP-GLVLLLLDVCCPQCDVLAYE 293
Cdd:cd15360 177 VLAFLIICACYIKIYLTVRNPNFVSS--------NSDTKIA--KRMAVLIFTDFLCMAPiSFFAISASLKVPLITVSKSK 246
                       250       260       270
                ....*....|....*....|....*....|.
gi 1857425  294 KFFLLLAEFNSAMNPIIYSYRDKemsaTFRQ 324
Cdd:cd15360 247 ILLVLFYPINSCANPFLYAIFTK----TFRR 273
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
59-322 4.39e-05

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 44.56  E-value: 4.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADffaGLAYFYLMFNTGpntrRLTVSTWLLRQGLIDTSLT----- 133
Cdd:cd15089  10 VCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALAD---ALATSTLPFQSA----KYLMETWPFGELLCKAVLSidyyn 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 --ASVANLLAIAIERHITV--------FRMQLHTRMSNrrvvvviVVIWTMAIVMGaIPSVGWNCICDIENCSNMAPLYS 203
Cdd:cd15089  83 mfTSIFTLTMMSVDRYIAVchpvkaldFRTPAKAKLIN-------ICIWVLSSGVG-VPIMVMAVTKTPRDGAVVCMLQF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  204 DSYLVFWAIFN-----LVTFVVMVVLYAHIFGYVRQRtMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP----G 274
Cdd:cd15089 155 PSPSWYWDTVTkicvfIFAFVVPILVITVCYGLMILR-LRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPihifV 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 1857425  275 LVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15089 234 IVWTLVDIDRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
59-312 4.50e-05

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 44.51  E-value: 4.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLaYFYLMFNTGPNTRRLTVS---TWLLRQGLIDTSLTA- 134
Cdd:cd15964  10 VNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGI-YLLLIASVDLHTRSEYYNhaiDWQTGPGCNTAGFFTv 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  135 -----SVANLLAIAIER-HITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNM--APLYSDSY 206
Cdd:cd15964  89 faselSVYTLTVITLERwYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMdtETPLAQAY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 LVFWAIFNLVTFVVMVVLYAHIFgyvrqRTMRMSRHSSGprrNRDTMMSllKTVVIVLGAFIICWTPGLVLLLLDVCCPQ 286
Cdd:cd15964 169 IVFVLMLNIIAFVIICACYIKIY-----ITVRNPQYKSG---DKDTKIA--KRMAVLIFTDFICMAPISFYALSAILNKP 238
                       250       260
                ....*....|....*....|....*..
gi 1857425  287 CDVLAYEKFFLLL-AEFNSAMNPIIYS 312
Cdd:cd15964 239 LITVSNSKILLVLfYPLNSCANPFLYA 265
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
135-322 4.61e-05

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 44.56  E-value: 4.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  135 SVANLLAIAIERHITV--------FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSvgwNCICDIENCSNMAPlysDSY 206
Cdd:cd15091  86 SIFTLTMMSVDRYIAVchpvkaldFRTPLKAKIINICIWLLSSSVGISAIVLGGTKV---REDVDSTECSLQFP---DDD 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 LVFWAIF-NLVTFV------VMVVLYAHIFGYVRQRTMRMSrhsSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLL 279
Cdd:cd15091 160 YSWWDTFmKICVFIfafvipVLIIIVCYTLMILRLKSVRLL---SGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFIL 236
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 1857425  280 LD--VCCPQCDVLAYEKFFLL-LAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15091 237 VEalGSVSHSTAAVSSYYFCIaLGYTNSSLNPILYAFLDENFKRCF 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
208-322 6.33e-05

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 44.09  E-value: 6.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  208 VFWAIFNLVTFVVMVVLYAHIFGYVRQRtMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC 287
Cdd:cd15092 163 VFGICVFLFSFIIPVLIISVCYSLMIRR-LRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQP 241
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 1857425  288 D---VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15092 242 SsetAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
58-324 1.02e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 43.44  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   58 TVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAAD--FFAGLAYFylmfntgpnTRRLTVSTWLLRQGLIDTSLTAS 135
Cdd:cd14970   9 VVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADelFLLGLPFL---------ATSYLLGYWPFGEVMCKIVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  136 VAN-------LLAIAIERHITVFRMQLHTRMSN-RRVVVVIVVIWTMAIVMG---AIPSVGWNCICDIENCSNMAPLYSD 204
Cdd:cd14970  80 AYNmftsifcLTVMSVDRYLAVVHPVKSLRFRTpRKAKLVSLCVWALSLVLGlpvIIFARTLQEEGGTISCNLQWPDPPD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  205 SYLVFWAIFNLV-----TFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDtmmSLLKTVVIVLGAFIICWTP---GLV 276
Cdd:cd14970 160 YWGRVFTIYTFVlgfavPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRARR---KVTRLVLVVVAVFVVCWLPfhvFQI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 1857425  277 LLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd14970 237 VRLLIDPPETLTVVGVFLFCIALSYANSCLNPILYAF----LDENFRK 280
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
133-326 2.29e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 42.64  E-value: 2.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 TASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP---------SVGWNCICDI-------ENC 195
Cdd:cd15319  85 TASILNLCVISVDRYWAISSpFRYERKMTQRVALVMISVAWTLSVLISFIPvqlnwhkdsGDDWVGLHNSsisrqveENC 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  196 -SNMAPLY--SDSYLVFWaifnlVTFVVMVVLYAHIFGYVRQRTMRMS------RHSSGPRRNR-----DTMM------- 254
Cdd:cd15319 165 dSSLNRTYaiSSSLISFY-----IPVAIMIVTYTRIYRIAQIQIRRISsleraaEHAQSCRSNRidchhHTSLrtsikke 239
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  255 -SLLKTVVIVLGAFIICWTPglvLLLLDVCCPQCDVLAYEK-------------FFLLLAEFNSAMNPIIYSYrdkemSA 320
Cdd:cd15319 240 tKVLKTLSVIMGVFVCCWLP---FFILNCMVPFCDRPPADPdaglpcvsettfdVFVWFGWANSSLNPIIYAF-----NA 311

                ....*.
gi 1857425  321 TFRQIL 326
Cdd:cd15319 312 DFRKVF 317
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
130-312 2.29e-04

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 42.57  E-value: 2.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITV---FRMqlhTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW---------NCIC---DIEN 194
Cdd:cd15137  89 LSSEVSVLILTLITLDRFICIvfpFSG---RRLGLRRAIIVLACIWLIGLLLAVLPLLPWdyfgnfygrSGVClplHITD 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  195 CSNMAPLYSdsyLVFWAIFNLVTFVVMVVLYAHIFGYVRQrtmrmSRHSSGPRRNRDTMMSLLKTVVIVLGAFiICWTPG 274
Cdd:cd15137 166 ERPAGWEYS---VFVFLGLNFLAFVFILLSYIAMFISIRR-----TRKAAASRKSKRDMAVAKRFFLIVLTDF-LCWIPI 236
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 1857425  275 LV---LLLLDVCCPQcDVLAYEKFFLLlaEFNSAMNPIIYS 312
Cdd:cd15137 237 IVigiLALSGVPIPG-EVYAWVAVFVL--PINSALNPILYT 274
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
57-273 2.30e-04

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 42.47  E-value: 2.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLA-------NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL-AYFYLMFntgpntrrLTVSTWLLRQG-- 126
Cdd:cd14975   1 VLGCTLLSLAfaiglpgNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLtLPVWIYF--------LATGTWDFGLAac 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 -----LIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVV-VIVVIWTMAIVMGAiPSVGWNCICDIENCSNMAP 200
Cdd:cd14975  73 kgcvyVCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHkVLAIIWLLAVLLAT-PVIAFRHVEETVENGMCKY 151
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1857425  201 L-YSDSYLVFWAIFN-----LVTFVVMVVLYAHIFGYVRQRTMRMSRHSsgprrnrdtmmslLKTVVIVLGAFIICWTP 273
Cdd:cd14975 152 RhYSDGQLVFHLLLEtvvgfAVPFTAVVLCYSCLLRRLRRRRFRRRRRT-------------GRLIASVVVAFAACWLP 217
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
57-316 3.41e-04

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 41.97  E-value: 3.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIM-------LANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTgpntrrLTVSTWLLRQG--- 126
Cdd:cd15213   1 ITLAILMIlmifvgfLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVT------IITGRWIFGDIfcr 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 ----LIDTSLTASVANLLAIAIERHITVFRMQlhTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI--------CDIEN 194
Cdd:cd15213  75 isamLYWFFVLEGVAILLIISVDRYLIIVQRQ--DKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYefpprapqCVLGY 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  195 CSNMAPLysdSYLVFWAIF-NLVTFVVMVVLYAHIFGYVRQRTMRMsrhssgprrnrdtmmslLKTVVIVLGAFIICWTP 273
Cdd:cd15213 153 TESPADR---IYVVLLLVAvFFIPFLIMLYSYFCILNTVRSFKTRA-----------------FTTILILFIGFSVCWLP 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 1857425  274 -GLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDK 316
Cdd:cd15213 213 yTVYSLLSVFSRYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIK 256
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
57-311 6.09e-04

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 41.27  E-value: 6.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIM--LANLLVMVAIYVNRRFHFPIYYLMANLAAADFfagLAYFYLMFNTGpnTRRLTVStWL-------LRQGL 127
Cdd:cd15384   6 VLAVMFVIsfIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADL---LVTFFCIPSEA--IWAYTVA-WLagntmckLVKYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 IDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVivviwTMAIVMGAIPSVGWNCICDIE---------NCSN- 197
Cdd:cd15384  80 QVFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMV-----TVAWILSPIFSIPQAVIFHVErgpfvedfhQCVTy 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  198 -------MAPLYSDSYLVFWAIFNLVtfvVMVVLYAHIFGYVRqRTMRMSRHSSGPRRNRDT----------MMSLLKTV 260
Cdd:cd15384 155 gfytaewQEQLYNMLSLVFMFPIPLV---IMVTCYVLIFITLS-KSSRDFQGLEIYTRNRGPnrqrlfhkakVKSLRMSA 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 1857425  261 VIVLgAFIICWTPGLVLLLLDV-CCPQCDVLAYEKFFLLLAEFNSAMNPIIY 311
Cdd:cd15384 231 VIVT-AFILCWTPYYVIMIWFLfFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
61-324 6.49e-04

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 40.85  E-value: 6.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMF-NTGPNTRRLTVSTWLLRQGLIDTSLTASVANL 139
Cdd:cd15409  12 LITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLvNFLSKNKMISFSGCAAQFFFFGFSATTECFLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  140 LAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSV--------GWNCI----CDIencsnmAPLY---- 202
Cdd:cd15409  92 AAMAYDRYVAICNpLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGltfrlsfcGSNEInhffCDI------PPLLkisc 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  203 SDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSS-GPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLD 281
Cdd:cd15409 166 TDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAeGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALD 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 1857425  282 VCCPqcDVLAYEKFFLLLaefnsamNPIIYSYRDKEMSATFRQ 324
Cdd:cd15409 246 QDMM--DSLFYTIVIPLL-------NPFIYSLRNKEVIDALRK 279
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
53-324 9.36e-04

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 40.33  E-value: 9.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   53 MGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADF--------FAGLAYFYLMFNTGPNTRRLTVstwLLR 124
Cdd:cd15210   4 AVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLlfcafnlpLAASTFLHQAWIHGETLCRVFP---LLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  125 QGLIDTSLTasvaNLLAIAIERHITVFRMQLHTRMSNRRV-VVVIVVIWTMAIVMGAIPSVG-WNCIC---DIENCSNMA 199
Cdd:cd15210  81 YGLVAVSLL----TLVLITLNRYILIAHPSLYPRIYTRRGlALMIAGTWIFSFGSFLPLWLGiWGRFGldpKVCSCSILR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  200 PLYSDSYLVFwaifnLVTFVVMVVLYAHIFGYVRQRTMRmsrhssgprrnrdtmmsLLKTVVIVLGAFIICWTPGLVLLL 279
Cdd:cd15210 157 DKKGRSPKTF-----LFVFGFVLPCLVIIICYARREDRR-----------------LTRMMLVIFLCFLVCYLPITLVNV 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 1857425  280 LD--VCCPQCDVLAYekfflLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15210 215 FDdeVAPPVLHIIAY-----VLIWLSSCINPIIYVA----MNRQYRQ 252
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
64-323 9.86e-04

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 40.55  E-value: 9.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   64 MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-----LAYFYLMFNTGpNTRRLTVSTWLLrqgLIDTSLTASVAN 138
Cdd:cd15199  15 LPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLiclpfKAYFYLNGNRW-SLGGGTCKALLF---MLSLSRGVSIAF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  139 LLAIAIERHITVFRMQLHTR-MSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCSNMAPLYSDSYLVFW--AIFNL 215
Cdd:cd15199  91 LTAVALDRYFRVVHPRGKKNsLSLQAAPYISFLVWLLLVGL-TIPTLLASQPKNFTECNSFSPKDDEDFSDTWqeAVFFL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  216 VTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRdtMMSLLKTVVIVLGafiICWTPGLVL-------LLLDVCCPQCD 288
Cdd:cd15199 170 QFLLPFGLIVFCTVRIIRRLKKRLRDVGKQPKLQR--AMALVTSVVVVFG---FCFLPCFLArvlmlifQNKESCNALNI 244
                       250       260       270
                ....*....|....*....|....*....|....*
gi 1857425  289 VLAYEKFFLLLAEFNSAMNPIIYSYRdkemSATFR 323
Cdd:cd15199 245 AVHTYDVTMCLTYLNSVLDPIVYCFS----SPTFR 275
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
218-324 1.15e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 40.34  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  218 FVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRN------RDTMMsllktVVIVLGAFIICWTPGLVL---LLLDVCCPQCD 288
Cdd:cd15095 179 LAIIAVCYGLILRRLWRRSVDGNNQSEQLSERalrqkrKVTRM-----VIVVVVLFAICWLPNHVLnlwQRFDPNFPETY 253
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 1857425  289 VLAYEKFF-LLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15095 254 ATYALKIAaLCLSYANSAVNPFVYAF----MGENFRK 286
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
55-322 1.33e-03

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 40.11  E-value: 1.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   55 LGItVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSL-T 133
Cdd:cd15086   7 LGF-ILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFgI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  134 ASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWN--------CICDIENCSNMAPlySDS 205
Cdd:cd15086  86 VSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSsygpegpgTTCSVQWTSRSAN--SIS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  206 YLVFWAIFNLVT-FVVMVVLYAHIFGYVRQRTmRMSRHSSGPRRNRDTMMsllktVVIVLGAFIICWTPGLVLLLL---- 280
Cdd:cd15086 164 YIICLFIFCLLLpFLVMVYCYGRLLYAIKQVG-KINKSTARKREQHVLLM-----VVTMVICYLLCWLPYGVMALLatfg 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 1857425  281 --DVCCPQCDVLAYekfflLLAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd15086 238 kpGLVTPVASIVPS-----ILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
56-273 1.36e-03

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 40.04  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   56 GITVCIFIMLA--NLLVMVAIYVNRRFHF-PIYYLMANLAAADFFAGLAYFYL--MFNTGPNTRRLTVSTWLLrQGLIDT 130
Cdd:cd15383   5 AVTFVLFVLSAcsNLAVLWSATRNRRRKLsHVRILILHLAAADLLVTFVVMPLdaAWNVTVQWYAGDLACRLL-MFLKLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  131 SLTASVANLLAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMgAIP----------SVGWNCICDIENCSNMAP 200
Cdd:cd15383  84 AMYSSAFVTVVISLDRHAAILN-PLAIGSARRRNRIMLCAAWGLSALL-ALPqlflfhtvtaTPPVNFTQCATHGSFPAH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSDSYLVF-WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGP---RRNRDT-----MMSLLKTVVIVLgAFIICW 271
Cdd:cd15383 162 WQETLYNMFtFFCLFLLPLLIMIFCYTRILLEISRRMKEKKDSAKNEvalRSSSDNipkarMRTLKMTIVIVS-SFIVCW 240

                ..
gi 1857425  272 TP 273
Cdd:cd15383 241 TP 242
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
57-311 1.77e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 39.69  E-value: 1.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFI--MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGPNTrrlTVStWL-------LRQGL 127
Cdd:cd15195   6 VTWVLFVisAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLM--VTFFNMPMDAVWNY---TVE-WLagdlmcrVMMFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  128 IDTSLTASVANLLAIAIERHITVFRMQLHTRmSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI---CDIENCSNMAPLYSD 204
Cdd:cd15195  80 KQFGMYLSSFMLVVIALDRVFAILSPLSANQ-ARKRVKIMLTVAWVLSALCSIPQSFIFSVLrkmPEQPGFHQCVDFGSA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  205 SYLVFWAIFNLVTFVVMVV--LYAHIFGYVR-----QRTMRMSRHSSGPRRN--------RDTMMSLLKTVVIVLgAFII 269
Cdd:cd15195 159 PTKKQERLYYFFTMILSFVipLIITVTCYLLilfeiSKMAKRARDTPISNRRrsrtnsleRARMRTLRMTALIVL-TFIV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 1857425  270 CWTPGLVLLLLDVCCPQCDVL---AYEKFFLLLAEFNSAMNPIIY 311
Cdd:cd15195 238 CWGPYYVLGLWYWFDKESIKNlppALSHIMFLLGYLNPCLHPIIY 282
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
129-273 1.87e-03

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 39.56  E-value: 1.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 DTSLTASVANLLAIAIERHIT-VFRMQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCSNMAPLYSDSYL 207
Cdd:cd15927  81 DTSIGVSVFTLTALSADRYFAiVNPMRKHRSQATRRTLVTAASIWIVSILL-AIPEAIFSHVVTFTLTDNQTIQICYPYP 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  208 VFW-------------AIFNLVTFVVMVVLYAHIFGYVRQRTMRM-SRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP 273
Cdd:cd15927 160 QELgpnypkimvllrfLVYYLIPLLIIGVFYVLMARHLIRSTRNIgSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLP 239
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
130-273 1.91e-03

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 39.55  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 TSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIENCSNMA-------PL 201
Cdd:cd15125  82 TSVGVSVFTLTALSADRYKAIVNpMDIQTSSAVLRTCLKAIAIWVVSVLL-AVPEAVFSEVAHIMPDDNTTftacipyPQ 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  202 YSD------SYLVFWAIFnLVTFVVMVVLYAHIfgyvrQRTMRMSRH------SSGPRRNRDTMMSLLKTVVIVLGAFII 269
Cdd:cd15125 161 TDEmhpkihSVLIFLVYF-LIPLAIISIYYYHI-----AKTLIKSAHnipgeySEHSKRQMETRKRLAKIVLVFVGLFAF 234

                ....
gi 1857425  270 CWTP 273
Cdd:cd15125 235 CWFP 238
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
57-311 1.99e-03

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 39.37  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIMLANLLVMVAIYVNR-RFHFPIYYLmANLAAADF-FAGLAYFYLMfnTGPNTRRLTVSTWLLR--QGLIDTSL 132
Cdd:cd15189   8 FSLCLFGLLGNLFVLLVFLLHRrRLTVAEIYL-GNLAAADLvFVSGLPFWAM--NILNQFNWPFGELLCRvvNGVIKVNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  133 TASVANLLAIAIERHITVFRMQLHTRMSNRRVV-VVIVVIWTMAIVMGaIPSVGWNCICDIENCSNMAPLYSDSYLVfWA 211
Cdd:cd15189  85 YTSIYLLVMISQDRYLALVKTMAARRLRRRRYAkLICVLIWVVGLLLS-IPTFLLRKIKAIPDLNITACVLLYPHEA-WH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  212 IFN---------LVTFVVMVVLYAHIFGYVRQRTMrmsrhSSGPRRNRDTMMSLLKTVVIVLgaFIICWTPGLVLLLLDV 282
Cdd:cd15189 163 FAHivllnivgfLLPLLVITFCNYNILQALRTREE-----STRCEDRNDSKATALVLAVTLL--FLVCWGPYHFFTFLDF 235
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 1857425  283 CCpQCDVLA---YEKFFLLLAEF-------NSAMNPIIY 311
Cdd:cd15189 236 LF-DVGVLDecfWEHFIDIGLQLavflafsNSCLNPVLY 273
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
47-319 2.18e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 39.38  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   47 TVSKLVMGLgitVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayfylmFNTGPNTRRLTVSTWLL-RQ 125
Cdd:cd15075   1 TILSIIMAV---FSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTV------FGGLLSVVTNAVGYFNLgRV 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  126 GLIDTSLT------ASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW----------NCI 189
Cdd:cd15075  72 GCVLEGFAvaffgiAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIASSWLWSLIWNTPPLFGWgsyqlegvmtSCA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  190 CDIENcsnmAPLYSDSYLVFWAIFNL-VTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRdtmMSLLKTVVIVLGAFI 268
Cdd:cd15075 152 PDWYS----RDPVNVSYILCYFSFCFaIPFAIILVSYGYLLWTLRQVAKLGVAEGGSTAKAE---VQVARMVVVMVMAFL 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 1857425  269 ICWTPGLVLLLLDVCCPQCDVLAYEKFF-LLLAEFNSAMNPIIYSYRDKEMS 319
Cdd:cd15075 225 LCWLPYAAFALTVVSKPDVYINPLIATVpMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
57-313 3.60e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 38.99  E-value: 3.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   57 ITVCIFIM--LANLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGPNTrrltVSTWLLRQGLI------ 128
Cdd:cd15205   6 TYVLIFVLalFGNSLVIYVVTRKRAMRTATNIFICSLALSDLL--ITFFCIPFTLLQNI----SSNWLGGAFMCkmvpfv 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  129 -DTSLTASVANLLAIAIERHI-TVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAI------------PSVGWNCICDIEN 194
Cdd:cd15205  80 qSTAVVTSILTMTCIAVERHQgIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPmlfvqqlevkydFLYEKRHVCCLER 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  195 CSNmaPLYSDSYLVF-WAIFNLVTFVVMVVLYAHIfGY---VRQR--------TMRMSRHSSGPRRNRDTmmslLKTVVI 262
Cdd:cd15205 160 WYS--PTQQKIYTTFiLVILFLLPLTTMLFLYSRI-GYelwIKKRvgdasvlqTIHGIEMSKISRKKKRA----VKMMVT 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 1857425  263 VLGAFIICWTP----GLVLLLLDVCCPQCDVLAYEKFFL--LLAEFNSAMNPIIYSY 313
Cdd:cd15205 233 VVLLFAVCWAPfhvvHMMIEYSNLENKYDGVTIKLIFAIvqLIGFSNSFNNPIVYAF 289
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
211-324 4.12e-03

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 38.63  E-value: 4.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  211 AIFNLVT---FVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVvIVLGAFIICWTPGLVLLLLDVCCpQC 287
Cdd:cd15920 156 GGINLTAvviFYILSLLFLYFYAKISHKLYKVSLGNAQQQIKKASKRAIIKTF-IVLAIFIVCFVPYHIVRVPYVLA-QI 233
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 1857425  288 DVLA----------YEKFFLLLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15920 234 DVISslpwkqtlhiANELVLCLSALNSCLDPIIYFF----LSSSFRR 276
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
90-324 5.06e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 38.17  E-value: 5.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   90 NLAAADFFaglayfYLMFNTGPNTRRLTVSTWLLR-------QGLIDTSLTASVANLLAIAIERHITVFR----MQLHTR 158
Cdd:cd15098  43 NLSIADLF------FLLFCVPFQATIYSLPEWVFGafmckfvHYFFTVSMLVSIFTLVAMSVDRYIAVVHsrtsSSLRTR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  159 msnRRVVVVIVVIWTMAIVMgAIPSV-----------GWNCICdIENCSNmaPLYSDSYLVFWAIFN-LVTFVVMVVLYA 226
Cdd:cd15098 117 ---RNALLGVLVIWVLSLAM-ASPVAvhqdlvhhwtaSNQTFC-WENWPE--KQQKPVYVVCTFVFGyLLPLLLITFCYA 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  227 HIFGYVRQRTMRMSRHSSGPRRNrdtmmsLLKTVVIVLGAFIICWTPGLVLLLLdvccpqcdvLAYEKF------FLL-- 298
Cdd:cd15098 190 KVLNHLHKKLKNMSKKSERSKKK------TAQTVLVVVVVFGISWLPHHIIHLW---------VEFGDFpltqasFVLri 254
                       250       260       270
                ....*....|....*....|....*....|
gi 1857425  299 ----LAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd15098 255 tahcLAYANSCVNPIIYAF----LSENFRK 280
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
208-326 5.75e-03

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 38.20  E-value: 5.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  208 VFWAIFnlvtfVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDtmmsllKTVVIVLGAFIICWTP--------GLVLLL 279
Cdd:cd15924 172 IFWIVF-----LLMIVCYTAITKKVYRSYRRVFRSSSSRRKKSN------VKIFIIVAVFFVCFVPyhfaripyTLSQTR 240
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 1857425  280 LDVCCPQCDVLAYEK-FFLLLAEFNSAMNPIIYSYrdkeMSATFRQIL 326
Cdd:cd15924 241 DVFDCTAENILFYVKeATLFLSALNVCLDPIIYFF----LCKSFRESL 284
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-322 6.11e-03

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 37.99  E-value: 6.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   51 LVMGLGITVCIFimlANLLVMVAIYVNRRFHFPIYYLMANLAAADffAGLAyfylMFNTGPNTRRLTVSTWLLRQGLID- 129
Cdd:cd16003   5 LAYGFVVAVAVF---GNLIVIWIILAHKRMRTVTNYFLVNLAFSD--ASMA----AFNTLINFIYALHSEWYFGEAYCRf 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 ------TSLTASVANLLAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCICDIEN---CSNMAP 200
Cdd:cd16003  76 hnffpiTSVFASIYSMTAIAVDRYMAIID-PLKPRLSATATKVVIGSIWILAFLL-AFPQCLYSKTKVMPGrtlCFVAWP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  201 LYSDSYLVFWAIFNLVTFV----VMVVLYAhIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLV 276
Cdd:cd16003 154 GGPDQHFTYHIIVIVLVYClpllVMGITYT-IVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHI 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 1857425  277 LLLLDVCCPQCDVLAYEKFFLL----LAEFNSAMNPIIYSYRDKEMSATF 322
Cdd:cd16003 233 YFIVTGLYQQLNRWKYIQQVYLasfwLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-323 6.65e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 38.14  E-value: 6.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   54 GLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFylmfntgPNTRRLTVS-TWLLRQGLID--- 129
Cdd:cd15208   5 ALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICL-------PATLLVDVTeTWFFGQVLCKiip 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  130 ----TSLTASVANLLAIAIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGwncicdIENCSNMAPL---- 201
Cdd:cd15208  78 ylqtVSVSVSVLTLSCIALDRWYAICH-PLMFKSTAKRARVSILIIWIVSLLI-MIPQAI------VMECSRVVPLankt 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  202 ---------YSDS------YLVFWAIFNLVTFVVMVVLYAHIF---------GY--VRQRTMRMSRHSSGPR-----RNR 250
Cdd:cd15208 150 illtvcderWSDSiyqkvyHICFFLVTYLLPLCLMILAYFQIFrklwcrqipGTssVVQRKWNKPRKSAVAAeekqlRSR 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  251 DTMMSLLKTVVIVlgaFIICWTPGLVLllldvccpqcDVLAYEKFFL---------------LLAEFNSAMNPIIYSYrd 315
Cdd:cd15208 230 RKTAKMLIVVVIM---FAICYLPVHLL----------NILRYVFGLFtvdretiyawflfshWLVYANSAINPIIYNF-- 294

                ....*...
gi 1857425  316 keMSATFR 323
Cdd:cd15208 295 --MSGKFR 300
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
61-324 8.26e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 37.45  E-value: 8.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   61 IFIM--LANLLVMVAIYVNRRFHFPIYYLMANLAAADFFaglayfYLMFNTGPNTRRLTVSTWLLR-------QGLIDTS 131
Cdd:cd14971  10 IFLLglVGNSLVILVVARNKPMRSTTNLFILNLAVADLT------FLLFCVPFTATIYPLPGWVFGdfmckfvHYFQQVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  132 LTASVANLLAIAIERHI-TVFRMQLHTRMSNRRVVVVIVVIW----TMAIVMGAIPSVGWNCICDIENCSNMAPLYsDSY 206
Cdd:cd14971  84 MHASIFTLVAMSLDRFLaVVYPLRSLHIRTPRNALAASGCIWvvslAVAAPVLALHRLRNYTPGNRTVCSEAWPSR-AHR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  207 LVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQ 286
Cdd:cd14971 163 RAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPF 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 1857425  287 cdVLAYEKFFL-----LLAEFNSAMNPIIYSYrdkeMSATFRQ 324
Cdd:cd14971 243 --PLTYATYALriwahCLAYSNSAVNPVLYAF----LSEHFRK 279
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
59-323 8.37e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 37.47  E-value: 8.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   59 VCIFIML----ANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA--------YFYLMFNTGPNTRRLTvstwllrQG 126
Cdd:cd15928   6 VCSVLMLvgasGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVlpldlyrlWRYRPWRFGDLLCRLM-------YF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  127 LIDTSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVgwncICDIENCSNMAPLYS-- 203
Cdd:cd15928  79 FSETCTYASILHITALSVERYLAIcHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALV----LVGVEHIQGQQTPRGfe 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  204 -----------DSYLVFWAIFNLVTFVVMVVLYAHIfGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLgAFIICWT 272
Cdd:cd15928 155 ctvvnvssgllSVMLWVSTSFFFVPMVCLSLLYGLI-GRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVL-AFVLCWL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1857425  273 P------------GLVLLLLDVcCPQCDVLAYEKFFLllaefNSAMNPIIYSYrdkeMSATFR 323
Cdd:cd15928 233 PfhvgrvifnhsrASTKHLHYV-SQYFNLVSFVLFYL-----SAAINPILYNL----MSKRYR 285
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
67-326 8.96e-03

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 37.50  E-value: 8.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425   67 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSL-TASVANLLAIAIE 145
Cdd:cd15078  18 NLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFgIVSIMTLTVLAYE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  146 RHITVfrmqLHTRMSNRR-VVVVIVVIWTMAIVMGAIPSVGWNCI--------CDIENCSNMAPLYSDSYLVFWAIFnLV 216
Cdd:cd15078  98 RYIRV----VHAKVVNFSwSWRAITYIWLYSLAWTGAPLLGWNRYtlevhglgCSFDWKSKDPNDTSFVLLFFLGCL-VV 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1857425  217 TFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLL------LDVCCPQCDVL 290
Cdd:cd15078 173 PLGIMAYCYGHILYEIRMLRSVEDLQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLlvtsgySKLVTPTIAII 252
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 1857425  291 AYekfflLLAEFNSAMNPIIYSYrdkeMSATFRQIL 326
Cdd:cd15078 253 PS-----LFAKSSTAYNPVIYIF----MIRKFRQCL 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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