|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03012 |
PLN03012 |
Camelliol C synthase |
1-759 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 1703.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1 MWKLKIANGNKEEPYLFSTNNFLGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIP 80
Cdd:PLN03012 1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 81 PAKVEDANNITSEIATNALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEIFTQDHRREVLRYIYCHQ 160
Cdd:PLN03012 81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 161 NEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGPGNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
Cdd:PLN03012 161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 241 PEFWILPSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQI 320
Cdd:PLN03012 241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 321 QDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISD 400
Cdd:PLN03012 321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 401 YLWIAEDGMKMQSFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDH 480
Cdd:PLN03012 401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 481 GWQASDCTAESFKCCLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEH 560
Cdd:PLN03012 481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEH 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 561 EYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLA 640
Cdd:PLN03012 561 EYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDCEA 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 641 MRKGVHFLLTTQKDNGGWGESYLSCPKKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDF 720
Cdd:PLN03012 641 IRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLENGDF 720
|
730 740 750
....*....|....*....|....*....|....*....
gi 3152599 721 PQQEITGAFMKNCLLHYAAYRNIFPVWALAEYRRRVPLP 759
Cdd:PLN03012 721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
779-1565 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 1688.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 779 MWRLKIGEGNGDDPYLFTTNNFAGRQTWEFDPDGGSPEERHSVVEARRIFYDNRFHVKASSDLLWRMQFLREKKFEQRIA 858
Cdd:PLN03012 1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 859 PVKVEDSEKVTFETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQ 938
Cdd:PLN03012 81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 939 KEDGGWGLHIEGHSTMFCTTLNYICMRILGESPDGGHDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMP 1018
Cdd:PLN03012 161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1019 PEFWILPSFFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLV 1098
Cdd:PLN03012 241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1099 QELVWDSLYIFAEPFLARWPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISD 1178
Cdd:PLN03012 321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1179 YLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPSGDYKSMYRHISKGAWTFSDRDH 1258
Cdd:PLN03012 401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1259 GWQVSDCTAHGLKCCLLFSMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGM 1338
Cdd:PLN03012 481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLS----------------------------LQSKNGGM 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1339 TAWEPAGAPKWLELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGN 1418
Cdd:PLN03012 533 TAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGN 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1419 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISNVVQTAWALMGLIH 1498
Cdd:PLN03012 613 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIH 692
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599 1499 SGQAERDPIPLHRAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEYRARVSLP 1565
Cdd:PLN03012 693 AGQAERDPIPLHRAAKLIINSQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
99-752 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 918.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 99 LRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGhlhEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMFC 178
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILG---IPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 179 TTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKMW 258
Cdd:cd02892 78 TVLNYVALRLLGVSPDDP---HMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 259 CYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHlcAKEDAYCPHPQIQDVIWNCLYIFTepflac 338
Cdd:cd02892 155 CWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWYE------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 339 WPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIH-FKKHLLRISDYLWIAEDGMKM-QSFGS 416
Cdd:cd02892 227 PLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPaFKRHLERIDDFLWLGPEGMKMcQTNGS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 417 QLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPsGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFKCCL 496
Cdd:cd02892 307 QVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQILDNP-GDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 497 LLSMIPPDivGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQALILF 576
Cdd:cd02892 386 RLQELPPF--GEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLF 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 577 KQLYPNHRtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQKDNG 656
Cdd:cd02892 464 GKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYENSPYIRKACDFLLSKQNPDG 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 657 GWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGAFMKNCLLH 736
Cdd:cd02892 543 GWGESYLSYEDKSYA--GGGRSTVVQTAWALLALMAAGEPDSE--AVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIR 618
|
650
....*....|....*.
gi 3152599 737 YAAYRNIFPVWALAEY 752
Cdd:cd02892 619 YHNYRNYFPLWALGRY 634
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
877-1558 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 901.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 877 LRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDevfTSEHRKEILRYIYCHQKEDGGWGLHIEGHSTMFC 956
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPI---DPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 957 TTLNYICMRILGESPDGGHdnaCGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKMW 1036
Cdd:cd02892 78 TVLNYVALRLLGVSPDDPH---MVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1037 SYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHlcAKEDTYYPRPLVQELVWDSLYIFaepflaR 1116
Cdd:cd02892 155 CWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWY------E 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1117 WPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVED-PNGDYFKKHLSRISDYLWMAEDGMKM-QSFGS 1194
Cdd:cd02892 227 PLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGyPDSPAFKRHLERIDDFLWLGPEGMKMcQTNGS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1195 QLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVgENPSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGLKCCL 1274
Cdd:cd02892 307 QVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQI-LDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1275 LFSMLAPDivGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWLELLN 1354
Cdd:cd02892 386 RLQELPPF--GEKVSRERLYDAVDWLLG----------------------------MQNSNGGFAAFEPDNTYHWLENLN 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1355 PTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRtTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFALAGL 1434
Cdd:cd02892 436 PFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEAL 514
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1435 AAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaqVGEISNVVQTAWALMGLIHSGQAERDPIplHRAAK 1514
Cdd:cd02892 515 AAAGEDYENSPYIRKACDFLLSKQNPDGGWGESYLSYEDKSYA--GGGRSTVVQTAWALLALMAAGEPDSEAV--ERGIK 590
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 3152599 1515 LIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEY 1558
Cdd:cd02892 591 YLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
|
|
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
98-754 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 796.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 98 ALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGhlheIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIAD----TPLPGYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:TIGR01787 77 GTVLAYVALKILGMSPDDP---AMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 258 WCYCRLVYMPMSYLYGKRFVGPISPlilqlREEIYLQPYAKinwNRARHLCAKEDAYCPHPQIQDVIWNCLYIFTEPFLa 337
Cdd:TIGR01787 154 WCRCRMVYLPMSYCYGERLSAPIDP-----REELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFL- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 338 cwpfNKLLREKALGVAMKHIHYEDensryiTIGCVEKALCMLACWVED-PNGIHFKKHLLRISDYLWIAEDGMKMQSFGS 416
Cdd:TIGR01787 225 ----RKALRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 417 QLWDSGFALQALVASNLV--NEIPDVLRRGYDFLKNSQVRENPSGDFtNMYRHISK-GSWTFSDRDHGW-QASDCTAESF 492
Cdd:TIGR01787 295 QVWDTAFAIQALRESGDHrlPEFHPALVKAHEWLLLSQIPDNPPGDW-KVYRHNLKpGGWAFSFLNCGYpDVDDTAVVAL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 493 KCCLLLSmiPPDivgpKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQA 572
Cdd:TIGR01787 374 KAVLLLQ--EDE----HVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQA 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 573 LILFkqlypNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQ 652
Cdd:TIGR01787 448 LGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRNCPEVQKACDWLLSRQ 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 653 KDNGGWGESYLSCPKKRYIPSEGerSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGAFM-K 731
Cdd:TIGR01787 523 MPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSE--AIERGVKYLLETQRPDGDWPQEYITGVGFpK 598
|
650 660
....*....|....*....|...
gi 3152599 732 NCLLHYAAYRNIFPVWALAEYRR 754
Cdd:TIGR01787 599 NFYLKYTNYRNIFPLWALGRYRQ 621
|
|
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
876-1560 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 785.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 876 ALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITghlDEVFTsEHRKEILRYIYCHQKEDGGWGLHIEGHSTMF 955
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIA---DTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 956 CTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKM 1035
Cdd:TIGR01787 77 GTVLAYVALKILGMSPD---DPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1036 WSYCRMVYLPMSYLYGKRFVGPITSlilqlRKELYLQPYEEinwMKVRHLCAKEDTYYPRPLVQELVWDSLYIFAEPFLA 1115
Cdd:TIGR01787 154 WCRCRMVYLPMSYCYGERLSAPIDP-----REELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFLR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1116 RWpfnklLREKALQLAMKHIHYEDensryiTIGCVEKVLCMLACWVED-PNGDYFKKHLSRISDYLWMAEDGMKMQSFGS 1194
Cdd:TIGR01787 226 KA-----LRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1195 QLWDTGFAMQALLASNLSS--EISDVLRRGHEFIKNSQVGENPSGDYKsMYRHISK-GAWTFSDRDHGW-QVSDCTAHGL 1270
Cdd:TIGR01787 295 QVWDTAFAIQALRESGDHRlpEFHPALVKAHEWLLLSQIPDNPPGDWK-VYRHNLKpGGWAFSFLNCGYpDVDDTAVVAL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1271 KCCLLFSmlAPDIVgpkqDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWL 1350
Cdd:TIGR01787 374 KAVLLLQ--EDEHV----KRDRLRDAVNWILG----------------------------MQSSNGGFAAYDPDNTGEWL 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1351 ELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKqlypdHRTTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFA 1430
Cdd:TIGR01787 420 ELLNPSEVFGDIMIDPPYVDVTARVIQALGAFG-----HRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFV 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1431 LAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGeiSNVVQTAWALMGLIHSGQAERDPIplH 1510
Cdd:TIGR01787 495 LSALAAAGRTYRNCPEVQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSEAI--E 570
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 3152599 1511 RAAKLIINSQLESGDFPQQQATGVFL-KNCTLHYAAYRNIHPLWALAEYRA 1560
Cdd:TIGR01787 571 RGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
98-755 |
3.07e-148 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 468.14 E-value: 3.07e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 98 ALRKGVNFLSALQASDGHWPAEnAGPLFFLPPLVFCLYvtgHLHEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:COG1657 24 AIAAAQALLLQQQDDGGWWGGE-LEADVTIAAEYILLH---HFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLS 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:COG1657 100 TTVKAYFALKLLGDDPDAP---HMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 258 WCYCRLVYMPMSYLYGKRFVGPISPLIlqLREEIYLQPYAKIN--WNRARHLCAKEDAYcphpQIQDVIWNclyiFTEPF 335
Cdd:COG1657 177 SYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPRDRSPWSRFF----LALDRLLR----AYERL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 336 LAcwpfnKLLREKALGVAMKHIHYEDENS-RYITIG-CVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAEDGMKMQS 413
Cdd:COG1657 247 PP-----KPLRRRALRKAEDWILERLEGDgGLGGIFpAMVNSLMALLALGYPPDHPVVRRALEALEKLLVETEDGARCQP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 414 FGSQLWDSGFALQALVASNlVNEIPDVLRRGYDFLKNSQVREnpSGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFK 493
Cdd:COG1657 322 CVSPVWDTALAVQALQEAG-LPEDHPALERAADWLLSKQILV--KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 494 CCLLLSMIPPDIVGPKMDPeqlyeAVTILLSLQSKNGGVTAWEPARGQEWLELLNptevFAD--IVVEHEYNECTSSAIQ 571
Cdd:COG1657 399 ALLRLRLPDEPRYREAIER-----AVEWILGMQSRDGGWGAFDKDNTKEWLNKIP----FADhgALLDPPTADVTARCLE 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 572 ALILFKQlypnhrtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNClAMRKGVHFLLTT 651
Cdd:COG1657 470 MLGQLGL-------TEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDP-AIRRAVAWLLSI 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 652 QKDNGGWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGA-FM 730
Cdd:COG1657 542 QNADGGWGEDCRSYEDPRYV--GLGPSTASQTAWALLALLAAGEADSP--AVARGIAYLLSTQREDGSWDEEYFTGTgFP 617
|
650 660
....*....|....*....|....*
gi 3152599 731 KNCLLHYAAYRNIFPVWALAEYRRR 755
Cdd:COG1657 618 RVFYLRYHLYRQYFPLWALARYRNL 642
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
875-1563 |
1.47e-147 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 466.60 E-value: 1.47e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 875 SALRRGIHFFSALQASDGHWPAEnAGPLFFLPPLVFCLYitgHLDEVFTSEHRKEILRYIYCHQKEDGGWGLHIEGHSTM 954
Cdd:COG1657 23 AAIAAAQALLLQQQDDGGWWGGE-LEADVTIAAEYILLH---HFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 955 FCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAK 1034
Cdd:COG1657 99 STTVKAYFALKLLGDDPD---APHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1035 MWSYCRMVYLPMSYLYGKRFVGPITSLIlqLRKELYLQPYEEINwmkvrhlcakedtYYPRPLVQELVWDSLYIFAEPFL 1114
Cdd:COG1657 176 FSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVD-------------YYFPAPRDRSPWSRFFLALDRLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1115 ARW-PFN-KLLREKALQLAMKHIHYEDENS-RYITIG-CVEKVLCMLACWVEDPNGDYFKKHLSRISDYLWMAEDGMKMQ 1190
Cdd:COG1657 241 RAYeRLPpKPLRRRALRKAEDWILERLEGDgGLGGIFpAMVNSLMALLALGYPPDHPVVRRALEALEKLLVETEDGARCQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1191 SFGSQLWDTGFAMQALLASNLsSEISDVLRRGHEFIKNSQVGEnpSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGL 1270
Cdd:COG1657 321 PCVSPVWDTALAVQALQEAGL-PEDHPALERAADWLLSKQILV--KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1271 KCcllfsMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWL 1350
Cdd:COG1657 398 MA-----LLRLRLPDEPRYREAIERAVEWILG----------------------------MQSRDGGWGAFDKDNTKEWL 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1351 ELLNptemFSD--IVIEHEYSECTSSAIQALSLFKQlypdhrtTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTW 1428
Cdd:COG1657 445 NKIP----FADhgALLDPPTADVTARCLEMLGQLGL-------TEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTW 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1429 FALAglaaagkTFN------DCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaQVGEiSNVVQTAWALMGLIHSGQA 1502
Cdd:COG1657 514 SVLT-------GLNaagvdpDDPAIRRAVAWLLSIQNADGGWGEDCRSYEDPRYV-GLGP-STASQTAWALLALLAAGEA 584
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3152599 1503 ERDPIplHRAAKLIINSQLESGDFPQQQATGV-FLKNCTLHYAAYRNIHPLWALAEYRARVS 1563
Cdd:COG1657 585 DSPAV--ARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLRG 644
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
877-1135 |
7.69e-40 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 149.94 E-value: 7.69e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 877 LRRGIHFFSALQASDGHW----------PAEnagplfflppLVFCLYITGHLDEvftsEHRKEILRYIYCHQKEDGGWGL 946
Cdd:pfam13249 1 IARAQDALLSLQHPDGHWvgeleanvtiTAE----------YILLRHFLGPDDP----ELEAKIARYLRSQQREDGGWPL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 947 HIEGHSTMFCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPS 1026
Cdd:pfam13249 67 FHGGPGDLSTTVEAYFALKLLGDSPD---APHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPR 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1027 FFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLIlqLRKELYLQPYEEINwmkvrhlcakedtYYPRPlVQELVWDSL 1106
Cdd:pfam13249 144 WFPFNIYKFSSWARTTIVPLLILSALKPVAPLPPGI--GLDELFVEPPENVR-------------YYPRP-HRLFSWTNL 207
|
250 260 270
....*....|....*....|....*....|.
gi 3152599 1107 YIFAEPFLARW-PFN-KLLREKALQLAMKHI 1135
Cdd:pfam13249 208 FLGLDRVLKLYeRLPpKPLRRRALRKAEEWI 238
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
416-754 |
1.72e-37 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 144.01 E-value: 1.72e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 416 SQLWDSGFALQALVASNLVNEIPdVLRRGYDFLKNSQVREnpSGDFTNMYRHISKGSWTFS-DRDHgWQASDCTAesfkc 494
Cdd:pfam13243 2 SPVWDTALALHALLEAGVPADHP-ALVKAAQWLLDRQVLV--KGDWAVKRPDLEPGGWAFQfANDH-YPDVDDTA----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 495 CLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGvtaWEPARGQEWLELLN--PtevFADivveHEYNECTSSA-IQ 571
Cdd:pfam13243 73 VVVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGG---WGAFDKDNTKYYLNkiP---FAD----HGALLDPPTAdVT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 572 ALILfkQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNClAMRKGVHFLLTT 651
Cdd:pfam13243 143 ARVL--EMLGQLGYPDDHPVAARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRP-YIRKAVDWLKSR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 652 QKDNGGWGE---SYlscpkKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITG- 727
Cdd:pfam13243 220 QNPDGGWGEdceSY-----KDPKLAGRGPSTASQTAWALLALMAAGEVDSP--AVRRGIQYLLETQKPDGTWDEPYFTGt 292
|
330 340
....*....|....*....|....*..
gi 3152599 728 AFMKNCLLHYAAYRNIFPVWALAEYRR 754
Cdd:pfam13243 293 GFPRVFYLKYHGYRNYFPLWALARYRN 319
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03012 |
PLN03012 |
Camelliol C synthase |
1-759 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 1703.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1 MWKLKIANGNKEEPYLFSTNNFLGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIP 80
Cdd:PLN03012 1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 81 PAKVEDANNITSEIATNALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEIFTQDHRREVLRYIYCHQ 160
Cdd:PLN03012 81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 161 NEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGPGNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
Cdd:PLN03012 161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 241 PEFWILPSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQI 320
Cdd:PLN03012 241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 321 QDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISD 400
Cdd:PLN03012 321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 401 YLWIAEDGMKMQSFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDH 480
Cdd:PLN03012 401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 481 GWQASDCTAESFKCCLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEH 560
Cdd:PLN03012 481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEH 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 561 EYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLA 640
Cdd:PLN03012 561 EYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDCEA 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 641 MRKGVHFLLTTQKDNGGWGESYLSCPKKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDF 720
Cdd:PLN03012 641 IRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLENGDF 720
|
730 740 750
....*....|....*....|....*....|....*....
gi 3152599 721 PQQEITGAFMKNCLLHYAAYRNIFPVWALAEYRRRVPLP 759
Cdd:PLN03012 721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
779-1565 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 1688.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 779 MWRLKIGEGNGDDPYLFTTNNFAGRQTWEFDPDGGSPEERHSVVEARRIFYDNRFHVKASSDLLWRMQFLREKKFEQRIA 858
Cdd:PLN03012 1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 859 PVKVEDSEKVTFETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQ 938
Cdd:PLN03012 81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 939 KEDGGWGLHIEGHSTMFCTTLNYICMRILGESPDGGHDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMP 1018
Cdd:PLN03012 161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1019 PEFWILPSFFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLV 1098
Cdd:PLN03012 241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1099 QELVWDSLYIFAEPFLARWPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISD 1178
Cdd:PLN03012 321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1179 YLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPSGDYKSMYRHISKGAWTFSDRDH 1258
Cdd:PLN03012 401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1259 GWQVSDCTAHGLKCCLLFSMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGM 1338
Cdd:PLN03012 481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLS----------------------------LQSKNGGM 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1339 TAWEPAGAPKWLELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGN 1418
Cdd:PLN03012 533 TAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGN 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1419 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISNVVQTAWALMGLIH 1498
Cdd:PLN03012 613 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIH 692
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599 1499 SGQAERDPIPLHRAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEYRARVSLP 1565
Cdd:PLN03012 693 AGQAERDPIPLHRAAKLIINSQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
1-754 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 1401.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1 MWKLKIANGNKEEPYLFSTNNFLGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIP 80
Cdd:PLN02993 1 MWKLKIGEGNGEDPYLFSSNNFVGRQTWEFDPKAGTPEERAAVEEARRSFLDNRSRVKGCSDLLWRMQFLKEAKFEQVIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 81 PAKVEDANNITSEIATNALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEIFTQDHRREVLRYIYCHQ 160
Cdd:PLN02993 81 PVKIDRGEEITYETATNALRRGVSFFSALQASDGHWPGEITGPLFFLPPLVFCLYITGHLEEVFDAEHRKEMLRHIYCHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 161 NEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGPGNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
Cdd:PLN02993 161 NEDGGWGLHIESKSVMFCTVLNYICLRMLGEGPNGGRENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 241 PEFWILPSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQI 320
Cdd:PLN02993 241 PEIWLLPSFLPIHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 321 QDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISD 400
Cdd:PLN02993 321 QDLIWDTLHNFVEPFLTRWPLNKLVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACWIENPNGDHFKKHLARIPD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 401 YLWIAEDGMKMQSFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDH 480
Cdd:PLN02993 401 YMWVAEDGMKMQSFGSQLWDTGFAIQALLASDLSDETDDVLRRGHNYIKKSQVRENPSGDFKSMYRHISKGAWTLSDRDH 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 481 GWQASDCTAESFKCCLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEH 560
Cdd:PLN02993 481 GWQVSDCTAEALKCCMLLSMMPADVVGQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVER 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 561 EYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLA 640
Cdd:PLN02993 561 EYVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYNDCLA 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 641 MRKGVHFLLTTQKDNGGWGESYLSCPKKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDF 720
Cdd:PLN02993 641 MRKGVHFLLTIQRDDGGWGESYLSCPEQRYIPLEGNRSNLVQTAWAMMGLIHAGQAERDLIPLHRAAKLIITSQLENGDF 720
|
730 740 750
....*....|....*....|....*....|....
gi 3152599 721 PQQEITGAFMKNCLLHYAAYRNIFPVWALAEYRR 754
Cdd:PLN02993 721 PQQEILGAFMNTCMLHYATYRNTFPLWALAEYRK 754
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
779-1559 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 1358.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 779 MWRLKIGEGNGDDPYLFTTNNFAGRQTWEFDPDGGSPEERHSVVEARRIFYDNRFHVKASSDLLWRMQFLREKKFEQRIA 858
Cdd:PLN02993 1 MWKLKIGEGNGEDPYLFSSNNFVGRQTWEFDPKAGTPEERAAVEEARRSFLDNRSRVKGCSDLLWRMQFLKEAKFEQVIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 859 PVKVEDSEKVTFETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQ 938
Cdd:PLN02993 81 PVKIDRGEEITYETATNALRRGVSFFSALQASDGHWPGEITGPLFFLPPLVFCLYITGHLEEVFDAEHRKEMLRHIYCHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 939 KEDGGWGLHIEGHSTMFCTTLNYICMRILGESPDGGHDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMP 1018
Cdd:PLN02993 161 NEDGGWGLHIESKSVMFCTVLNYICLRMLGEGPNGGRENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1019 PEFWILPSFFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLV 1098
Cdd:PLN02993 241 PEIWLLPSFLPIHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1099 QELVWDSLYIFAEPFLARWPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISD 1178
Cdd:PLN02993 321 QDLIWDTLHNFVEPFLTRWPLNKLVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACWIENPNGDHFKKHLARIPD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1179 YLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPSGDYKSMYRHISKGAWTFSDRDH 1258
Cdd:PLN02993 401 YMWVAEDGMKMQSFGSQLWDTGFAIQALLASDLSDETDDVLRRGHNYIKKSQVRENPSGDFKSMYRHISKGAWTLSDRDH 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1259 GWQVSDCTAHGLKCCLLFSMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGM 1338
Cdd:PLN02993 481 GWQVSDCTAEALKCCMLLSMMPADVVGQKIDPEQLYDSVNLLLS----------------------------LQSENGGV 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1339 TAWEPAGAPKWLELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGN 1418
Cdd:PLN02993 533 TAWEPVRAYKWLELLNPTDFFANTMVEREYVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGN 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1419 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISNVVQTAWALMGLIH 1498
Cdd:PLN02993 613 WGICFIYATWFALGGLAAAGKTYNDCLAMRKGVHFLLTIQRDDGGWGESYLSCPEQRYIPLEGNRSNLVQTAWAMMGLIH 692
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3152599 1499 SGQAERDPIPLHRAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEYR 1559
Cdd:PLN02993 693 AGQAERDLIPLHRAAKLIITSQLENGDFPQQEILGAFMNTCMLHYATYRNTFPLWALAEYR 753
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
99-752 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 918.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 99 LRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGhlhEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMFC 178
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILG---IPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 179 TTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKMW 258
Cdd:cd02892 78 TVLNYVALRLLGVSPDDP---HMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 259 CYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHlcAKEDAYCPHPQIQDVIWNCLYIFTepflac 338
Cdd:cd02892 155 CWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWYE------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 339 WPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIH-FKKHLLRISDYLWIAEDGMKM-QSFGS 416
Cdd:cd02892 227 PLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPaFKRHLERIDDFLWLGPEGMKMcQTNGS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 417 QLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPsGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFKCCL 496
Cdd:cd02892 307 QVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQILDNP-GDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 497 LLSMIPPDivGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQALILF 576
Cdd:cd02892 386 RLQELPPF--GEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLF 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 577 KQLYPNHRtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQKDNG 656
Cdd:cd02892 464 GKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYENSPYIRKACDFLLSKQNPDG 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 657 GWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGAFMKNCLLH 736
Cdd:cd02892 543 GWGESYLSYEDKSYA--GGGRSTVVQTAWALLALMAAGEPDSE--AVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIR 618
|
650
....*....|....*.
gi 3152599 737 YAAYRNIFPVWALAEY 752
Cdd:cd02892 619 YHNYRNYFPLWALGRY 634
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
877-1558 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 901.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 877 LRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDevfTSEHRKEILRYIYCHQKEDGGWGLHIEGHSTMFC 956
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPI---DPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 957 TTLNYICMRILGESPDGGHdnaCGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKMW 1036
Cdd:cd02892 78 TVLNYVALRLLGVSPDDPH---MVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1037 SYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHlcAKEDTYYPRPLVQELVWDSLYIFaepflaR 1116
Cdd:cd02892 155 CWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWY------E 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1117 WPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVED-PNGDYFKKHLSRISDYLWMAEDGMKM-QSFGS 1194
Cdd:cd02892 227 PLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGyPDSPAFKRHLERIDDFLWLGPEGMKMcQTNGS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1195 QLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVgENPSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGLKCCL 1274
Cdd:cd02892 307 QVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQI-LDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1275 LFSMLAPDivGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWLELLN 1354
Cdd:cd02892 386 RLQELPPF--GEKVSRERLYDAVDWLLG----------------------------MQNSNGGFAAFEPDNTYHWLENLN 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1355 PTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRtTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFALAGL 1434
Cdd:cd02892 436 PFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEAL 514
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1435 AAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaqVGEISNVVQTAWALMGLIHSGQAERDPIplHRAAK 1514
Cdd:cd02892 515 AAAGEDYENSPYIRKACDFLLSKQNPDGGWGESYLSYEDKSYA--GGGRSTVVQTAWALLALMAAGEPDSEAV--ERGIK 590
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 3152599 1515 LIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEY 1558
Cdd:cd02892 591 YLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
|
|
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
98-754 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 796.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 98 ALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGhlheIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIAD----TPLPGYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:TIGR01787 77 GTVLAYVALKILGMSPDDP---AMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 258 WCYCRLVYMPMSYLYGKRFVGPISPlilqlREEIYLQPYAKinwNRARHLCAKEDAYCPHPQIQDVIWNCLYIFTEPFLa 337
Cdd:TIGR01787 154 WCRCRMVYLPMSYCYGERLSAPIDP-----REELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFL- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 338 cwpfNKLLREKALGVAMKHIHYEDensryiTIGCVEKALCMLACWVED-PNGIHFKKHLLRISDYLWIAEDGMKMQSFGS 416
Cdd:TIGR01787 225 ----RKALRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 417 QLWDSGFALQALVASNLV--NEIPDVLRRGYDFLKNSQVRENPSGDFtNMYRHISK-GSWTFSDRDHGW-QASDCTAESF 492
Cdd:TIGR01787 295 QVWDTAFAIQALRESGDHrlPEFHPALVKAHEWLLLSQIPDNPPGDW-KVYRHNLKpGGWAFSFLNCGYpDVDDTAVVAL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 493 KCCLLLSmiPPDivgpKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQA 572
Cdd:TIGR01787 374 KAVLLLQ--EDE----HVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQA 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 573 LILFkqlypNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQ 652
Cdd:TIGR01787 448 LGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRNCPEVQKACDWLLSRQ 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 653 KDNGGWGESYLSCPKKRYIPSEGerSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGAFM-K 731
Cdd:TIGR01787 523 MPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSE--AIERGVKYLLETQRPDGDWPQEYITGVGFpK 598
|
650 660
....*....|....*....|...
gi 3152599 732 NCLLHYAAYRNIFPVWALAEYRR 754
Cdd:TIGR01787 599 NFYLKYTNYRNIFPLWALGRYRQ 621
|
|
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
876-1560 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 785.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 876 ALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITghlDEVFTsEHRKEILRYIYCHQKEDGGWGLHIEGHSTMF 955
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIA---DTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 956 CTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKM 1035
Cdd:TIGR01787 77 GTVLAYVALKILGMSPD---DPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1036 WSYCRMVYLPMSYLYGKRFVGPITSlilqlRKELYLQPYEEinwMKVRHLCAKEDTYYPRPLVQELVWDSLYIFAEPFLA 1115
Cdd:TIGR01787 154 WCRCRMVYLPMSYCYGERLSAPIDP-----REELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFLR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1116 RWpfnklLREKALQLAMKHIHYEDensryiTIGCVEKVLCMLACWVED-PNGDYFKKHLSRISDYLWMAEDGMKMQSFGS 1194
Cdd:TIGR01787 226 KA-----LRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1195 QLWDTGFAMQALLASNLSS--EISDVLRRGHEFIKNSQVGENPSGDYKsMYRHISK-GAWTFSDRDHGW-QVSDCTAHGL 1270
Cdd:TIGR01787 295 QVWDTAFAIQALRESGDHRlpEFHPALVKAHEWLLLSQIPDNPPGDWK-VYRHNLKpGGWAFSFLNCGYpDVDDTAVVAL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1271 KCCLLFSmlAPDIVgpkqDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWL 1350
Cdd:TIGR01787 374 KAVLLLQ--EDEHV----KRDRLRDAVNWILG----------------------------MQSSNGGFAAYDPDNTGEWL 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1351 ELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKqlypdHRTTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFA 1430
Cdd:TIGR01787 420 ELLNPSEVFGDIMIDPPYVDVTARVIQALGAFG-----HRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFV 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1431 LAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGeiSNVVQTAWALMGLIHSGQAERDPIplH 1510
Cdd:TIGR01787 495 LSALAAAGRTYRNCPEVQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSEAI--E 570
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 3152599 1511 RAAKLIINSQLESGDFPQQQATGVFL-KNCTLHYAAYRNIHPLWALAEYRA 1560
Cdd:TIGR01787 571 RGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
106-752 |
6.56e-165 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 512.62 E-value: 6.56e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 106 LSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEiftQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMFCTTLNYIC 185
Cdd:TIGR03463 1 LAALQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPD---AEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 186 MRILGEGPNGGpgnACKRARDWILDH-GGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKMWCYCRLV 264
Cdd:TIGR03463 78 LRLLGLGKDDA---GLARARAWFHAQpEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 265 YMPMSYLYGKRFVGPIS-PLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQIQDVIWNCLYIFTEpflACWpfnK 343
Cdd:TIGR03463 155 YLGIAWLSGRGARAPESdPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYER---LAG---K 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 344 LLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAED-GMKMQSFGS-QLWDS 421
Cdd:TIGR03463 229 ALRARALDFAFEQILAEDEATHYICIGPINGLLNCLAIFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSnALWDT 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 422 GFALQALVAS-NLVNEIPDVLRRGYDFLKNSQVRENpSGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFKCCLLLSM 500
Cdd:TIGR03463 309 AFAVQALAALgELDEEAKHALEEAAAFIDAAQMLAD-LADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 501 IPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQALILFKQLY 580
Cdd:TIGR03463 388 LGDNRISEALGAARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHH 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 581 PNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNcLAMRKGVHFLLTTQKDNGGWGE 660
Cdd:TIGR03463 468 PDLPDAKIDAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPAD-MALQAAAAFLLEKQRADGAWGE 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 661 SYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDPSplHRAAKLLINSQLENGDFPQQEITGAFMKNCLLHYAAY 740
Cdd:TIGR03463 547 HVESCLEARWV--EGKHGHAVMTAWALLALAAAGEAAHDAA--ERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAY 622
|
650
....*....|..
gi 3152599 741 RNIFPVWALAEY 752
Cdd:TIGR03463 623 LRIFPTWALARC 634
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
886-1558 |
1.16e-161 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 503.76 E-value: 1.16e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 886 ALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEvftSEHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNYICMR 965
Cdd:TIGR03463 3 ALQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPD---AEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 966 ILGESPDgghDNACGRAREWILSH-GGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKMWSYCRMVYL 1044
Cdd:TIGR03463 80 LLGLGKD---DAGLARARAWFHAQpEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1045 PMSYLYGKRFVGPITS-LILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLVQELVWDSLYIFaepflARWPFnKLL 1123
Cdd:TIGR03463 157 GIAWLSGRGARAPESDpLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGY-----ERLAG-KAL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1124 REKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISDYLWMAED-GMKMQSFGS-QLWDTGF 1201
Cdd:TIGR03463 231 RARALDFAFEQILAEDEATHYICIGPINGLLNCLAIFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSnALWDTAF 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1202 AMQALLAS-NLSSEISDVLRRGHEFIKNSQVGENpSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGLKCCLLFSMLA 1280
Cdd:TIGR03463 311 AVQALAALgELDEEAKHALEEAAAFIDAAQMLAD-LADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELG 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1281 PDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWLELLNPTEMFS 1360
Cdd:TIGR03463 390 DNRISEALGAARLQDAVEFILS----------------------------MQNADGGFATYELQRGGKLLELLNPSDMFG 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1361 DIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFALAGLAAAGKT 1440
Cdd:TIGR03463 442 QCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAE 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1441 FNDcEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAqvGEISNVVQTAWALMGLIHSGQAERDPIplHRAAKLIINSQ 1520
Cdd:TIGR03463 522 PAD-MALQAAAAFLLEKQRADGAWGEHVESCLEARWVE--GKHGHAVMTAWALLALAAAGEAAHDAA--ERGIAWLCEQQ 596
|
650 660 670
....*....|....*....|....*....|....*...
gi 3152599 1521 LESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEY 1558
Cdd:TIGR03463 597 GEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
413-752 |
1.18e-151 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 465.93 E-value: 1.18e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 413 SFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPsGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESF 492
Cdd:cd02889 20 GEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQIRDNP-DDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEAL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 493 KCCLLLSMIPPDivGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELlnPTEVFADIVVEHEYNECTSSAIQA 572
Cdd:cd02889 99 KALLRLQKKPPD--GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 573 LILFKQLYPNHRtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTyNNCLAMRKGVHFLLTTQ 652
Cdd:cd02889 175 LGLFGKLYPEHR-REIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGED-ENSPYVRKACDWLLSKQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 653 KDNGGWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDPspLHRAAKLLINSQLENGDFPQQEITGAFMKN 732
Cdd:cd02889 253 NPDGGWGESYESYEDPSYA--GGGRSTVVQTAWALLALMAAGEPDSEA--VKRGVKYLLNTQQEDGDWPQEEITGVFFKN 328
|
330 340
....*....|....*....|
gi 3152599 733 CLLHYAAYRNIFPVWALAEY 752
Cdd:cd02889 329 FYIRYHNYRNYFPLWALGRY 348
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
98-755 |
3.07e-148 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 468.14 E-value: 3.07e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 98 ALRKGVNFLSALQASDGHWPAEnAGPLFFLPPLVFCLYvtgHLHEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:COG1657 24 AIAAAQALLLQQQDDGGWWGGE-LEADVTIAAEYILLH---HFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLS 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:COG1657 100 TTVKAYFALKLLGDDPDAP---HMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 258 WCYCRLVYMPMSYLYGKRFVGPISPLIlqLREEIYLQPYAKIN--WNRARHLCAKEDAYcphpQIQDVIWNclyiFTEPF 335
Cdd:COG1657 177 SYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPRDRSPWSRFF----LALDRLLR----AYERL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 336 LAcwpfnKLLREKALGVAMKHIHYEDENS-RYITIG-CVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAEDGMKMQS 413
Cdd:COG1657 247 PP-----KPLRRRALRKAEDWILERLEGDgGLGGIFpAMVNSLMALLALGYPPDHPVVRRALEALEKLLVETEDGARCQP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 414 FGSQLWDSGFALQALVASNlVNEIPDVLRRGYDFLKNSQVREnpSGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFK 493
Cdd:COG1657 322 CVSPVWDTALAVQALQEAG-LPEDHPALERAADWLLSKQILV--KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 494 CCLLLSMIPPDIVGPKMDPeqlyeAVTILLSLQSKNGGVTAWEPARGQEWLELLNptevFAD--IVVEHEYNECTSSAIQ 571
Cdd:COG1657 399 ALLRLRLPDEPRYREAIER-----AVEWILGMQSRDGGWGAFDKDNTKEWLNKIP----FADhgALLDPPTADVTARCLE 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 572 ALILFKQlypnhrtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNClAMRKGVHFLLTT 651
Cdd:COG1657 470 MLGQLGL-------TEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDP-AIRRAVAWLLSI 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 652 QKDNGGWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGA-FM 730
Cdd:COG1657 542 QNADGGWGEDCRSYEDPRYV--GLGPSTASQTAWALLALLAAGEADSP--AVARGIAYLLSTQREDGSWDEEYFTGTgFP 617
|
650 660
....*....|....*....|....*
gi 3152599 731 KNCLLHYAAYRNIFPVWALAEYRRR 755
Cdd:COG1657 618 RVFYLRYHLYRQYFPLWALARYRNL 642
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
875-1563 |
1.47e-147 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 466.60 E-value: 1.47e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 875 SALRRGIHFFSALQASDGHWPAEnAGPLFFLPPLVFCLYitgHLDEVFTSEHRKEILRYIYCHQKEDGGWGLHIEGHSTM 954
Cdd:COG1657 23 AAIAAAQALLLQQQDDGGWWGGE-LEADVTIAAEYILLH---HFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 955 FCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAK 1034
Cdd:COG1657 99 STTVKAYFALKLLGDDPD---APHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1035 MWSYCRMVYLPMSYLYGKRFVGPITSLIlqLRKELYLQPYEEINwmkvrhlcakedtYYPRPLVQELVWDSLYIFAEPFL 1114
Cdd:COG1657 176 FSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVD-------------YYFPAPRDRSPWSRFFLALDRLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1115 ARW-PFN-KLLREKALQLAMKHIHYEDENS-RYITIG-CVEKVLCMLACWVEDPNGDYFKKHLSRISDYLWMAEDGMKMQ 1190
Cdd:COG1657 241 RAYeRLPpKPLRRRALRKAEDWILERLEGDgGLGGIFpAMVNSLMALLALGYPPDHPVVRRALEALEKLLVETEDGARCQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1191 SFGSQLWDTGFAMQALLASNLsSEISDVLRRGHEFIKNSQVGEnpSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGL 1270
Cdd:COG1657 321 PCVSPVWDTALAVQALQEAGL-PEDHPALERAADWLLSKQILV--KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1271 KCcllfsMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWL 1350
Cdd:COG1657 398 MA-----LLRLRLPDEPRYREAIERAVEWILG----------------------------MQSRDGGWGAFDKDNTKEWL 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1351 ELLNptemFSD--IVIEHEYSECTSSAIQALSLFKQlypdhrtTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTW 1428
Cdd:COG1657 445 NKIP----FADhgALLDPPTADVTARCLEMLGQLGL-------TEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTW 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1429 FALAglaaagkTFN------DCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaQVGEiSNVVQTAWALMGLIHSGQA 1502
Cdd:COG1657 514 SVLT-------GLNaagvdpDDPAIRRAVAWLLSIQNADGGWGEDCRSYEDPRYV-GLGP-STASQTAWALLALLAAGEA 584
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3152599 1503 ERDPIplHRAAKLIINSQLESGDFPQQQATGV-FLKNCTLHYAAYRNIHPLWALAEYRARVS 1563
Cdd:COG1657 585 DSPAV--ARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLRG 644
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
1191-1558 |
1.07e-136 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 425.87 E-value: 1.07e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1191 SFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPsGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGL 1270
Cdd:cd02889 20 GEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQIRDNP-DDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEAL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1271 KCCLLFSMLAPDivGPKQDPERLHDSVNILLSLQvsiirhrieptsskkhpfsgrdsftclqSKNGGMTAWEPAGAPKWL 1350
Cdd:cd02889 99 KALLRLQKKPPD--GKKVSRERLYDAVDWLLSMQ----------------------------NSNGGFAAFEPDNTYKYL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1351 ELlnPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTtEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFA 1430
Cdd:cd02889 149 EL--IPEVDGDIMIDPPYVECTGSVLEALGLFGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1431 LAGLAAAGKTfNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaqVGEISNVVQTAWALMGLIHSGQAERDPIplH 1510
Cdd:cd02889 226 LEALAAAGED-ENSPYVRKACDWLLSKQNPDGGWGESYESYEDPSYA--GGGRSTVVQTAWALLALMAAGEPDSEAV--K 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 3152599 1511 RAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEY 1558
Cdd:cd02889 301 RGVKYLLNTQQEDGDWPQEEITGVFFKNFYIRYHNYRNYFPLWALGRY 348
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
870-1559 |
4.45e-54 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 201.27 E-value: 4.45e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 870 FETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEvftsEHRKEILRYIYCHQKEDGGWGLHIE 949
Cdd:TIGR01507 11 TARTVEAIDRAVDYLLSCQKDEGYWWGELESNVTIEAEYVLLCHILDRVDR----DRMEKIRNYLLHEQREDGTWALYPG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 950 GHSTMFCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFP 1029
Cdd:TIGR01507 87 GPGDLSTTVEAYVALKYIGMSRD---EPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1030 VHPAKMWSYCRMVYLPMSYLYGKRFVGPITSlilQLR-KELYlqpyeEINWMKVRHLCAKEDTyyprPLVQELVWDSLYI 1108
Cdd:TIGR01507 164 FNIYEFSSWARATVVPLSIVCSRKPVFPLPE---RARvPELY-----ETDVPKPRRRGAKGGT----GWGIFDALDRALH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1109 FAEPFLARwPFnkllREKALQLAMKHIHYEDENS------------RYITIgcveKVLCMlacwveDPNGDYFKKHLSRI 1176
Cdd:TIGR01507 232 GYEKLSVH-PF----RRAAEIRALDWLLERQAGDgswggiqpamfnALIAL----KILGM------TQHDAFIKLGWEGI 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1177 SDYLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEiSDVLRRGHEFIKNSQVgeNPSGDYKSMYRHISKGAWTFS-D 1255
Cdd:TIGR01507 297 DLYGVELDDSWMFQACVSPVWDTALAVLALREAGLPAD-HDALVKAGEWLLDKQI--TVPGDWAVKRPNLEPGGWAFQfD 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1256 RDHGWQVSDctahglKCCLLFSMLApdIVGPkqDPERLHDSVNILLSLQVSiirhrieptsskkhpfsgrdsftcLQSKN 1335
Cdd:TIGR01507 374 NVYYPDVDD------TAVVVWALNG--LRLP--DERRRRDAMTKAFRWIAG------------------------MQSSN 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1336 GGMTAWEPAGAPKWLELLNptemFSDI--VIEHEYSECTSSAIQALSLFKQLYPDHRtteitafIKKAAEYLENMQTRDG 1413
Cdd:TIGR01507 420 GGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGYDDAWPV-------IERAVEYLKREQEPDG 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1414 SWYGNWGICFTYGTWfALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQvgEISNVVQTAWAL 1493
Cdd:TIGR01507 489 SWFGRWGVNYLYGTG-AVLSALKAVGIDTREPYIQKALAWLESHQNPDGGWGEDCRSYEDPAYAGK--GASTASQTAWAL 565
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599 1494 MGLIHSGQAERDPIplHRAAKLIINSQLESGDFPQQQATGV-FLKNCTLHYAAYRNIHPLWALAEYR 1559
Cdd:TIGR01507 566 IALIAAGRAESEAA--RRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHMYRHVFPLLALARYK 630
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
392-752 |
3.19e-46 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 168.88 E-value: 3.19e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 392 KKHLLRISDYLwIAEDGMKMQSFGSQLWDSGFALQAL----VASNLVNEIPDVLRRGYDFLKNSQvrenpsgdftnmyrh 467
Cdd:cd00688 2 EKHLKYLLRYP-YGDGHWYQSLCGEQTWSTAWPLLALllllAATGIRDKADENIEKGIQRLLSYQ--------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 468 ISKGSWTFSDRdHGWQASDCTAESFKCCLLLSMIPPdivgpkMDPEQLYEAVTILLSLQSKNGGVTAWEPargqewlell 547
Cdd:cd00688 66 LSDGGFSGWGG-NDYPSLWLTAYALKALLLAGDYIA------VDRIDLARALNWLLSLQNEDGGFREDGP---------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 548 npteVFADIVVEHEYNECTSSAIQALILFKQLYPNhrteeinTSIKKAVQYIESIQMLDGSWyGSWGVCFTYSTWFGLGG 627
Cdd:cd00688 129 ----GNHRIGGDESDVRLTAYALIALALLGKLDPD-------PLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 628 LAAAGKTynNCLAMRKGVHFLLTTQKDNGGWGESYLSCPKkryipsegeRSNLVQTSWAMMGLLHAGQAeRDPSPLHRAA 707
Cdd:cd00688 197 LALLGDL--DSPDAKKALRWLLSRQRPDGGWGEGRDRTNK---------LSDSCYTEWAAYALLALGKL-GDLEDAEKLV 264
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 3152599 708 KLLINSQLENGDFPQQEItgafmknclLHYAAYRNIFPVWALAEY 752
Cdd:cd00688 265 KWLLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
98-753 |
8.58e-45 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 173.54 E-value: 8.58e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 98 ALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLheifTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:TIGR01507 17 AIDRAVDYLLSCQKDEGYWWGELESNVTIEAEYVLLCHILDRV----DRDRMEKIRNYLLHEQREDGTWALYPGGPGDLS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:TIGR01507 93 TTVEAYVALKYIGMSRDEP---PMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 258 WCYCRLVYMPMSYLYGKRFVGPIsPLILQLREEIYLQPyakinwnrarhlcAKEDAYCPHPQiqdVIWNClyiftepFLA 337
Cdd:TIGR01507 170 SSWARATVVPLSIVCSRKPVFPL-PERARVPELYETDV-------------PKPRRRGAKGG---TGWGI-------FDA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 338 CWPFNKLL--------REKALGVAMKHI--HYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAED 407
Cdd:TIGR01507 226 LDRALHGYeklsvhpfRRAAEIRALDWLleRQAGDGSWGGIQPAMFNALIALKILGMTQHDAFIKLGWEGIDLYGVELDD 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 408 GMKMQSFGSQLWDSGFALQALVASNLVNEiPDVLRRGYDFLKNSQVreNPSGDFTNMYRHISKGSWTFSDRDHGWQASDC 487
Cdd:TIGR01507 306 SWMFQACVSPVWDTALAVLALREAGLPAD-HDALVKAGEWLLDKQI--TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDD 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 488 TAeSFKCCLLLSMIPPDivgPKMDpEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNptevFADI--VVEHEYNEC 565
Cdd:TIGR01507 383 TA-VVVWALNGLRLPDE---RRRR-DAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADV 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 566 TSSAIQALILFKQLYPNHRteeintsIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGkTYNNCLAMRKGV 645
Cdd:TIGR01507 454 TARVLECLGSFGYDDAWPV-------IERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVG-IDTREPYIQKAL 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 646 HFLLTTQKDNGGWGESYLSCPKKRYipsEGE-RSNLVQTSWAMMGLLHAGQAERdpSPLHRAAKLLINSQLENGDFPQQE 724
Cdd:TIGR01507 526 AWLESHQNPDGGWGEDCRSYEDPAY---AGKgASTASQTAWALIALIAAGRAES--EAARRGVQYLVETQRPDGGWDEPY 600
|
650 660 670
....*....|....*....|....*....|
gi 3152599 725 ITG-AFMKNCLLHYAAYRNIFPVWALAEYR 753
Cdd:TIGR01507 601 YTGtGFPGDFYLGYHMYRHVFPLLALARYK 630
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
877-1135 |
7.69e-40 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 149.94 E-value: 7.69e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 877 LRRGIHFFSALQASDGHW----------PAEnagplfflppLVFCLYITGHLDEvftsEHRKEILRYIYCHQKEDGGWGL 946
Cdd:pfam13249 1 IARAQDALLSLQHPDGHWvgeleanvtiTAE----------YILLRHFLGPDDP----ELEAKIARYLRSQQREDGGWPL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 947 HIEGHSTMFCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPS 1026
Cdd:pfam13249 67 FHGGPGDLSTTVEAYFALKLLGDSPD---APHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPR 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1027 FFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLIlqLRKELYLQPYEEINwmkvrhlcakedtYYPRPlVQELVWDSL 1106
Cdd:pfam13249 144 WFPFNIYKFSSWARTTIVPLLILSALKPVAPLPPGI--GLDELFVEPPENVR-------------YYPRP-HRLFSWTNL 207
|
250 260 270
....*....|....*....|....*....|.
gi 3152599 1107 YIFAEPFLARW-PFN-KLLREKALQLAMKHI 1135
Cdd:pfam13249 208 FLGLDRVLKLYeRLPpKPLRRRALRKAEEWI 238
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
1170-1558 |
5.30e-38 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 145.00 E-value: 5.30e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1170 KKHLSRISDYLwmAEDGMKMQSF-GSQLWDTGFAMQALL----ASNLSSEISDVLRRGHEFIKNSQvgenpsgdyksmyr 1244
Cdd:cd00688 2 EKHLKYLLRYP--YGDGHWYQSLcGEQTWSTAWPLLALLlllaATGIRDKADENIEKGIQRLLSYQ-------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1245 hISKGAWTFSDRdHGWQVSDCTAHGLKCcllFSMLAPDIvgpKQDPERLHDSVNILLSLQvsiirhrieptsskkhpfsg 1324
Cdd:cd00688 66 -LSDGGFSGWGG-NDYPSLWLTAYALKA---LLLAGDYI---AVDRIDLARALNWLLSLQ-------------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1325 rdsftclqSKNGGMTAWEPagapkwlellnpteMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRtteitafIKKAAEY 1404
Cdd:cd00688 118 --------NEDGGFREDGP--------------GNHRIGGDESDVRLTAYALIALALLGKLDPDPL-------IEKALDY 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1405 LENMQTRDGSWyGNWGICFTYGTWFALAGLAAAGKTfnDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKiyiaqvgeiS 1484
Cdd:cd00688 169 LLSCQNYDGGF-GPGGESHGYGTACAAAALALLGDL--DSPDAKKALRWLLSRQRPDGGWGEGRDRTNKL---------S 236
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3152599 1485 NVVQTAWALMGLIHSGQAeRDPIPLHRAAKLIINSQLESGDFPQQQAtgvflknctLHYAAYRNIHPLWALAEY 1558
Cdd:cd00688 237 DSCYTEWAAYALLALGKL-GDLEDAEKLVKWLLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
416-754 |
1.72e-37 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 144.01 E-value: 1.72e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 416 SQLWDSGFALQALVASNLVNEIPdVLRRGYDFLKNSQVREnpSGDFTNMYRHISKGSWTFS-DRDHgWQASDCTAesfkc 494
Cdd:pfam13243 2 SPVWDTALALHALLEAGVPADHP-ALVKAAQWLLDRQVLV--KGDWAVKRPDLEPGGWAFQfANDH-YPDVDDTA----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 495 CLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGvtaWEPARGQEWLELLN--PtevFADivveHEYNECTSSA-IQ 571
Cdd:pfam13243 73 VVVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGG---WGAFDKDNTKYYLNkiP---FAD----HGALLDPPTAdVT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 572 ALILfkQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNClAMRKGVHFLLTT 651
Cdd:pfam13243 143 ARVL--EMLGQLGYPDDHPVAARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRP-YIRKAVDWLKSR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 652 QKDNGGWGE---SYlscpkKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITG- 727
Cdd:pfam13243 220 QNPDGGWGEdceSY-----KDPKLAGRGPSTASQTAWALLALMAAGEVDSP--AVRRGIQYLLETQKPDGTWDEPYFTGt 292
|
330 340
....*....|....*....|....*..
gi 3152599 728 AFMKNCLLHYAAYRNIFPVWALAEYRR 754
Cdd:pfam13243 293 GFPRVFYLKYHGYRNYFPLWALARYRN 319
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
99-357 |
9.74e-30 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 120.67 E-value: 9.74e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 99 LRKGVNFLSALQASDGHWpaenagplfflpplVFCL---------YVTghLHEIF-TQDHRRE--VLRYIYCHQNEDGGW 166
Cdd:pfam13249 1 IARAQDALLSLQHPDGHW--------------VGELeanvtitaeYIL--LRHFLgPDDPELEakIARYLRSQQREDGGW 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 167 GLHIEGNSTMFCTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWIL 246
Cdd:pfam13249 65 PLFHGGPGDLSTTVEAYFALKLLGDSPDAP---HMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 247 PSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLIlqLREEIYLQPYAKINWNRARHlcakedaycphpqiQDVIWN 326
Cdd:pfam13249 142 PRWFPFNIYKFSSWARTTIVPLLILSALKPVAPLPPGI--GLDELFVEPPENVRYYPRPH--------------RLFSWT 205
|
250 260 270
....*....|....*....|....*....|...
gi 3152599 327 CLYIFTEPFLACW-PFN-KLLREKALGVAMKHI 357
Cdd:pfam13249 206 NLFLGLDRVLKLYeRLPpKPLRRRALRKAEEWI 238
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
1194-1559 |
1.24e-29 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 121.29 E-value: 1.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1194 SQLWDTGFAMQALLASNLSSEIsDVLRRGHEFIKNSQVGEnpSGDYKSMYRHISKGAWTFS-DRDHgwqvsdctahglkc 1272
Cdd:pfam13243 2 SPVWDTALALHALLEAGVPADH-PALVKAAQWLLDRQVLV--KGDWAVKRPDLEPGGWAFQfANDH-------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1273 cllfsmlAPDIvgpkqdperlHDSVNILLSLQVSIIRHRIEPTSSKKHpfsGRDSFTCLQSKNGGMTAWEpagAPKWLEL 1352
Cdd:pfam13243 65 -------YPDV----------DDTAVVVLALDRVRLPDERRRDDAIAR---GIEWILGMQSKNGGWGAFD---KDNTKYY 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1353 LN--PtemFSDI--VIEHEYSECTSsaiQALSLFKQL-YPDHRTTeitafIKKAAEYLENMQTRDGSWYGNWGICFTYGT 1427
Cdd:pfam13243 122 LNkiP---FADHgaLLDPPTADVTA---RVLEMLGQLgYPDDHPV-----AARALEYLKKEQEPDGSWFGRWGVNYIYGT 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1428 WFALAGLAAAGKTFNDcEAIRKGVQFLLAAQKDNGGWGE---SYlscsKKIYIAQVGEiSNVVQTAWALMGLIHSGQAER 1504
Cdd:pfam13243 191 WSVLCGLAAVGEDHNR-PYIRKAVDWLKSRQNPDGGWGEdceSY----KDPKLAGRGP-STASQTAWALLALMAAGEVDS 264
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 3152599 1505 DpiPLHRAAKLIINSQLESGDFPQQQATGV-FLKNCTLHYAAYRNIHPLWALAEYR 1559
Cdd:pfam13243 265 P--AVRRGIQYLLETQKPDGTWDEPYFTGTgFPRVFYLKYHGYRNYFPLWALARYR 318
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
513-754 |
2.89e-13 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 74.67 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 513 EQLYEAVTILLSLQSKNGGVTAWEPARGQEwlellNPTEVFA----DIVVEHEYNECTSSAIQALILFKQLYPNHRTEei 588
Cdd:TIGR04277 383 DAIDEGAEFLFSMQNDDGGFPAFDKGKMED-----NLLFKFAfkiaGIADSAEIFDPSCPDITAHILEGLGEFGDQAN-- 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 589 NTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAmRKGVHFLLTTQKDNGGWGESYLSC--P 666
Cdd:TIGR04277 456 HDQIQKMIKYFMDTQEKFGSWEARWGINYIMAAGAVLPALAKMNYDLNEGWA-KNAINWLLNKQNADGGFGECTLSYndP 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 667 KKRyipSEGERSNLVQTSWAMMGLLHA-GQAERDPSPLHRAAK-LLINSQLENGDFPQQEITGAFMKNCL-LHYAAYRNI 743
Cdd:TIGR04277 535 EKW---NGIGKSTVTQTSWGLLALLAVeDHNDQIKEAADKAAQyLLDQFKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQS 611
|
250
....*....|.
gi 3152599 744 FPVWALAEYRR 754
Cdd:TIGR04277 612 FPLIALGRFLD 622
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
592-632 |
1.88e-09 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 54.44 E-value: 1.88e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 3152599 592 IKKAVQYIESIQMLDGSWYGSWGVC-FTYSTWFGLGGLAAAG 632
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
1398-1526 |
2.45e-07 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 54.48 E-value: 2.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1398 IKKAAEYLENMQTRDGSWYG------NWGICF-TYGTWFALAGLAAAGKTFndcEAIRKGVQFLLAAQKDNGGWGESYLS 1470
Cdd:cd00688 1 IEKHLKYLLRYPYGDGHWYQslcgeqTWSTAWpLLALLLLLAATGIRDKAD---ENIEKGIQRLLSYQLSDGGFSGWGGN 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599 1471 CSkkiyiaqvgeiSNVVQTAWALMGLIHSGQAE-RDPIPLHRAAKLIINSQLESGDF 1526
Cdd:cd00688 78 DY-----------PSLWLTAYALKALLLAGDYIaVDRIDLARALNWLLSLQNEDGGF 123
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
1398-1558 |
2.99e-07 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 55.02 E-value: 2.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1398 IKKAAEYLENMQTRDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDcEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYI 1477
Cdd:TIGR04277 459 IQKMIKYFMDTQEKFGSWEARWGINYIMAAGAVLPALAKMNYDLNE-GWAKNAINWLLNKQNADGGFGECTLSYNDPEKW 537
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1478 AQVGeISNVVQTAWALMGLIH-SGQAERDPIPLHRAAK-LIINSQLESGDFPQQQATGVFLKNCT-LHYAAYRNIHPLWA 1554
Cdd:TIGR04277 538 NGIG-KSTVTQTSWGLLALLAvEDHNDQIKEAADKAAQyLLDQFKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIA 616
|
....
gi 3152599 1555 LAEY 1558
Cdd:TIGR04277 617 LGRF 620
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
925-968 |
4.55e-06 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 44.81 E-value: 4.55e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 3152599 925 EHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNYICMRILG 968
Cdd:pfam00432 1 IDKEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
147-189 |
5.20e-05 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 41.73 E-value: 5.20e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 3152599 147 DHRREVLRYIYCHQNEDGGWGLHIEGNSTMFCTTLNYICMRIL 189
Cdd:pfam00432 1 IDKEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALL 43
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
93-226 |
1.72e-04 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 45.62 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 93 EIATNALRKGVNFLSALQASDGHWPAENAGPlfflPPLVFC-LYVTGHL-----HEIFTQDHRREVLRYIYCHQNEDGGW 166
Cdd:cd00688 48 DKADENIEKGIQRLLSYQLSDGGFSGWGGND----YPSLWLtAYALKALllagdYIAVDRIDLARALNWLLSLQNEDGGF 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3152599 167 GLHIEGNSTMFC----TTLNYICMRILGEGPNGGPGNACKRARDWILDHggATYIPSWGKTWLS 226
Cdd:cd00688 124 REDGPGNHRIGGdesdVRLTAYALIALALLGKLDPDPLIEKALDYLLSC--QNYDGGFGPGGES 185
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1375-1507 |
3.00e-04 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 44.69 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 1375 AIQALSLFKQLYPDHRTtEITAFIKKAAEYLENMQTRDGSwYGNWGICFTYGTW--------FALAGLAaagkTFNDCEA 1446
Cdd:cd02891 29 VLKYLDATGQLTPEIRE-KALEYIRKGYQRLLTYQRSDGS-FSAWGNSDSGSTWltayvvkfLSQARKY----IDVDENV 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3152599 1447 IRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISnvvQTAWALMGLIHSGQAERDPI 1507
Cdd:cd02891 103 LARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVS---LTAYVLIALAEAGKACDASI 160
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
871-1004 |
4.11e-04 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 44.08 E-value: 4.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 871 ETATSALRRGIHFFSALQASDGHWPAENAGPlfflPPLVF-------CLYITGHLDEVfTSEHRKEILRYIYCHQKEDGG 943
Cdd:cd00688 48 DKADENIEKGIQRLLSYQLSDGGFSGWGGND----YPSLWltayalkALLLAGDYIAV-DRIDLARALNWLLSLQNEDGG 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3152599 944 WGLHIEGHSTMFC----TTLNYICMRILGESPDGGHDNACGRAREWILSHggVTYIPSWGKTWLS 1004
Cdd:cd00688 123 FREDGPGNHRIGGdesdVRLTAYALIALALLGKLDPDPLIEKALDYLLSC--QNYDGGFGPGGES 185
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
877-1003 |
4.52e-04 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 44.52 E-value: 4.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 877 LRRGIHFFSALQASDGHWPAEnagplfFLPPLVFCLYITGHLDEVFTSEHRKEI---LRYI--------------YCHQK 939
Cdd:cd02889 1 IRRALDFLLSLQAPDGHWPGE------YSQVWDTALALQALLEAGLAPEFDPALkkaLEWLlksqirdnpddwkvKYRHL 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3152599 940 EDGGWGLHIEGHS-TMF-CTTLNYICMRILGESPDGG---HDNACGRAREWILS----HGGV-TYIPSWGKTWL 1003
Cdd:cd02889 75 RKGGWAFSTANQGyPDSdDTAEALKALLRLQKKPPDGkkvSRERLYDAVDWLLSmqnsNGGFaAFEPDNTYKYL 148
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
641-719 |
5.67e-04 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 44.13 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 641 MRKGVHFLLTTQKDNGGWGesylscpkkryipseGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQ-LENGD 719
Cdd:cd02889 1 IRRALDFLLSLQAPDGHWP---------------GEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQiRDNPD 65
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
1398-1429 |
8.48e-04 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 38.65 E-value: 8.48e-04
10 20 30
....*....|....*....|....*....|...
gi 3152599 1398 IKKAAEYLENMQTRDGSWYGNWGIC-FTYGTWF 1429
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYC 35
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
877-989 |
2.01e-03 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 42.15 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 877 LRRGIHFFSALQASDGHWPAENAGP---LFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQKEDGGWGLHIEGHST 953
Cdd:cd00688 1 IEKHLKYLLRYPYGDGHWYQSLCGEqtwSTAWPLLALLLLLAATGIRDKADENIEKGIQRLLSYQLSDGGFSGWGGNDYP 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 3152599 954 -MFCTTLNYICMRILGESPDGGHDNACgRAREWILSH 989
Cdd:cd00688 81 sLWLTAYALKALLLAGDYIAVDRIDLA-RALNWLLSL 116
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
1447-1520 |
2.43e-03 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 41.82 E-value: 2.43e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3152599 1447 IRKGVQFLLAAQKDNGGWgesylscskkiyiaqVGEISNVVQTAWALMGLIHSGQAERDPIPLHRAAKLIINSQ 1520
Cdd:cd02889 1 IRRALDFLLSLQAPDGHW---------------PGEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQ 59
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
93-179 |
7.62e-03 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 40.23 E-value: 7.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599 93 EIATNALRKGVNFLSALQASDGHWPAEnaGPLFFLPPLV--------FCLYVTGHLHEIFTQDHRREVLRYIYCHQNEDG 164
Cdd:cd00688 100 AVDRIDLARALNWLLSLQNEDGGFRED--GPGNHRIGGDesdvrltaYALIALALLGKLDPDPLIEKALDYLLSCQNYDG 177
|
90
....*....|....*..
gi 3152599 165 GWGLHIE--GNSTMFCT 179
Cdd:cd00688 178 GFGPGGEshGYGTACAA 194
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
99-119 |
8.70e-03 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 40.28 E-value: 8.70e-03
10 20
....*....|....*....|.
gi 3152599 99 LRKGVNFLSALQASDGHWPAE 119
Cdd:cd02889 1 IRRALDFLLSLQAPDGHWPGE 21
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