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Conserved domains on  [gi|1935056|gb|AAB51776|]
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mitochondrial NADH dehydrogenase-ubiquinone Fe-S protein 8, 23 kDa subunit precursor [Homo sapiens]

Protein Classification

NuoI/complex I 23 kDa subunit family protein( domain architecture ID 11481829)

NuoI/complex I 23 kDa subunit family protein such as bacterial NADH-quinone oxidoreductase subunit I (NuoI), which is part of the connecting domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

EC:  7.1.1.-
Gene Ontology:  GO:0016651|GO:0051539|GO:0016020
PubMed:  23417064|33957129|24059520

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
54-210 1.67e-93

NADH-quinone oxidoreductase subunit NuoI;


:

Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 270.21  E-value: 1.67e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    54 RAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPR 133
Cdd:PRK05888   3 QYLKSMLLKELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAAER 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1935056   134 ADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR 210
Cdd:PRK05888  83 EDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
54-210 1.67e-93

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 270.21  E-value: 1.67e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    54 RAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPR 133
Cdd:PRK05888   3 QYLKSMLLKELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAAER 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1935056   134 ADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR 210
Cdd:PRK05888  83 EDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 67-188 1.96e-62

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 189.93  E-value: 1.96e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056     67 GLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDID 146
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1935056    147 MTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKL 188
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 108-180 7.36e-22

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 84.80  E-value: 7.36e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEpradgsRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPnFEFSTETHEE 180
Cdd:COG1143   1 EDKCIGCGLCVRVCPVDAITIEDG------EPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 108-166 1.98e-16

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 72.43  E-value: 1.98e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRADgsrrttrydIDMTKCIYCGFCQEACPVDAIV 166
Cdd:cd10549  77 EEKCIGCGLCVKVCPVDAITLEDELEIV---------IDKEKCIGCGICAEVCPVNAIK 126
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 111-164 2.30e-12

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 59.46  E-value: 2.30e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1935056    111 CIACKLCEAICPAQAITIEAEPRADGsrrTTRYDIDMTKCIYCGFCQEACPVDA 164
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKG---TKTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 75-165 1.46e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 47.16  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    75 LFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAE-PRADGsrrttrydidmtKCIYC 153
Cdd:NF038196 151 GPEKKKGFIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGkPVWGH------------NCTHC 218

                         90
                 ....*....|..
gi 1935056   154 GFCQEACPVDAI 165
Cdd:NF038196 219 LACIHRCPKEAI 230
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
54-210 1.67e-93

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 270.21  E-value: 1.67e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    54 RAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPR 133
Cdd:PRK05888   3 QYLKSMLLKELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAAER 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1935056   134 ADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR 210
Cdd:PRK05888  83 EDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 67-188 1.96e-62

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 189.93  E-value: 1.96e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056     67 GLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDID 146
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1935056    147 MTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKL 188
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 108-180 7.36e-22

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 84.80  E-value: 7.36e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEpradgsRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPnFEFSTETHEE 180
Cdd:COG1143   1 EDKCIGCGLCVRVCPVDAITIEDG------EPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
ndhI CHL00014
NADH dehydrogenase subunit I
 52-185 8.23e-19

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 79.80  E-value: 8.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    52 TDRAARTLlwtelFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGehalrRYPSGEERCIACKLCEAICPAQAITIEAE 131
Cdd:CHL00014  12 TIRAARYI-----GQGFMITLSHANRLPVTIQYPYEKLITSERFRG-----RIHFEFDKCIACEVCVRVCPIDLPVVDWK 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1935056   132 PRAD-GSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNK 185
Cdd:CHL00014  82 LETDiRKKRLLNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQ 136
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 79-186 4.36e-17

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 75.45  E-value: 4.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    79 PATINYPFEKGPLSPRFRG--EHALrrypsgeERCIACKLCEAICPAQAITIEAepraDGSRRTTRYDIDMTKCIYCGFC 156
Cdd:PRK12387  13 TATSSYPLEPIAVDKNFRGkpEYNP-------QQCIGCAACVNACPSNALTVET----DLATGELAWEFNLGRCIFCGRC 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 1935056   157 QEACPVDAIVEGPNFEFSTETHEELLYNKE 186
Cdd:PRK12387  82 EEVCPTAAIKLSQEFELAVWKKEDLLQQSE 111
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 108-166 1.98e-16

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 72.43  E-value: 1.98e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRADgsrrttrydIDMTKCIYCGFCQEACPVDAIV 166
Cdd:cd10549  77 EEKCIGCGLCVKVCPVDAITLEDELEIV---------IDKEKCIGCGICAEVCPVNAIK 126
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 80-185 4.51e-15

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 70.17  E-value: 4.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    80 ATINYPFEKGPLSPRFRGEHALrrypsGEERCIACKLCEAICPAQAITIEAepraDGSRRTTRYDIDMTKCIYCGFCQEA 159
Cdd:PRK08222  14 ATVKYPFAPLEVSPGFRGKPDL-----MPSQCIACGACTCACPANALTIQT----DDQQNSRTWQLYLGRCIYCGRCEEV 84

                         90       100
                 ....*....|....*....|....*.
gi 1935056   160 CPVDAIVEGPNFEFsTETHEELLYNK 185
Cdd:PRK08222  85 CPTRAIQLTNNFEL-TVTNKADLYTR 109
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 108-187 1.04e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 67.81  E-value: 1.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056  108 EERCIACKLCEAICPAQAITIEaepraDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEK 187
Cdd:cd10549   5 PEKCIGCGICVKACPTDAIELG-----PNGAIARGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDEEK 79
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
99-172 1.08e-14

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 66.29  E-value: 1.08e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1935056   99 HALRRYPSGEERCIACKLCEAICPAQAITIEAEPradgsrrttrYDIDMTKCIYCGFCQEACPVDAIVEGPNFE 172
Cdd:COG2768   1 HSLGKPYVDEEKCIGCGACVKVCPVGAISIEDGK----------AVIDPEKCIGCGACIEVCPVGAIKIEWEED 64
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 108-173 1.78e-14

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 65.46  E-value: 1.78e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEpradgsrrttRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEF 173
Cdd:COG2221  14 EEKCIGCGLCVAVCPTGAISLDDG----------KLVIDEEKCIGCGACIRVCPTGAIKGEKPKKF 69
PRK13984 PRK13984
putative oxidoreductase; Provisional
 74-160 3.31e-13

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 67.48  E-value: 3.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    74 YLFREPATINYPFEKGPLSPRFRGEHAlrrypSGEERCIACKLCEAICPAQAIT---IEAEPRADGSrRTTRYDIDMTKC 150
Cdd:PRK13984  15 FLFRKPVTIKVPNVKREAAERYRGFHI-----NDWEKCIGCGTCSKICPTDAITmveVPDLPQEYGK-KPQRPVIDYGRC 88

                         90
                 ....*....|
gi 1935056   151 IYCGFCQEAC 160
Cdd:PRK13984  89 SFCALCVDIC 98
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 108-165 6.21e-13

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 63.18  E-value: 6.21e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  108 EERCIACKLCEAICPAQAITIEaEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:cd10549  39 EDKCVFCGACVEVCPTGAIELT-PEGKEYVPKEKEAEIDEEKCIGCGLCVKVCPVDAI 95
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 108-166 7.38e-13

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 61.60  E-value: 7.38e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRAdgsrrttrydIDMTKCIYCGFCQEACPVDAIV 166
Cdd:COG4231  21 EDKCTGCGACVKVCPADAIEEGDGKAV----------IDPDLCIGCGSCVQVCPVDAIK 69
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 111-164 2.30e-12

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 59.46  E-value: 2.30e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1935056    111 CIACKLCEAICPAQAITIEAEPRADGsrrTTRYDIDMTKCIYCGFCQEACPVDA 164
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKG---TKTVVIDPERCVGCGACVAVCPTGA 51
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 108-166 7.24e-12

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 58.91  E-value: 7.24e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEpradgsrrtTRYDIDMTKCIYCGFCQEACPVDAIV 166
Cdd:COG1144  29 EDKCIGCGLCWIVCPDGAIRVDDG---------KYYGIDYDYCKGCGICAEVCPVKAIE 78
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 108-169 1.02e-11

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 58.20  E-value: 1.02e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEpradgsrrtTRYDIDMTKCIYCGFCQEACPVDAIVEGP 169
Cdd:COG1149  10 EEKCIGCGLCVEVCPEGAIKLDDG---------GAPVVDPDLCTGCGACVGVCPTGAITLEE 62
NapF COG1145
Ferredoxin [Energy production and conversion];
108-165 1.25e-11

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 62.05  E-value: 1.25e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEpradgsrrTTRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:COG1145 181 AEKCIGCGLCVKVCPTGAIRLKDG--------KPQIVVDPDKCIGCGACVKVCPVGAI 230
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 108-165 5.69e-11

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 56.26  E-value: 5.69e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEpradgSRRTTRYDIDmtKCIYCGFCQEACPVDAI 165
Cdd:COG1146   7 TDKCIGCGACVEVCPVDVLELDEE-----GKKALVINPE--ECIGCGACELVCPVGAI 57
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 68-176 7.58e-11

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 57.15  E-value: 7.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    68 LGMTLSYLFREPATINYP-FEKGPLSPRFRGEHALRRypsgeERCIACKLCEAICPAQAITIEAEPRadgsrrttRYDID 146
Cdd:PRK08348   5 LPTVLRNLFKKPATNLFPaTEPVPVPEDFRGKILYDV-----DKCVGCRMCVTVCPAGVFVYLPEIR--------KVALW 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 1935056   147 MTKCIYCGFCQEACPVDAIVEGPNFEFSTE 176
Cdd:PRK08348  72 TGRCVFCGQCVDVCPTGALQMSDDFLLASY 101
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
108-167 1.04e-09

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 57.34  E-value: 1.04e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056  108 EERCIACKLCEAICPAQAITIEaepraDGSRRttrydIDMTKCIYCGFCQEACPVDAIVE 167
Cdd:COG4624  90 KEKCKNCYPCVRACPVKAIKVD-----DGKAE-----IDEEKCISCGQCVAVCPFGAITE 139
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
108-165 1.31e-09

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 56.79  E-value: 1.31e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRAdgsrrttryDIDMTKCIYCGFCQEACPVDAI 165
Cdd:COG1148 495 PEKCTGCGRCVEVCPYGAISIDEKGVA---------EVNPALCKGCGTCAAACPSGAI 543
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
111-167 1.44e-09

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 56.09  E-value: 1.44e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1935056   111 CIACKLCEAICPAQAITIEaepradgsrrTTRYDIDMTKCIYCGFCQEACPVDAIVE 167
Cdd:PRK07118 215 CIGCGKCVKACPAGAITME----------NNLAVIDQEKCTSCGKCVEKCPTKAIRI 261
Fer4_9 pfam13187
4Fe-4S dicluster domain;
110-165 6.26e-09

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 50.24  E-value: 6.26e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1935056    110 RCIACKLCEAICPAQAITIeaepraDGSRRTTRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVP------DLVGQTIRGDIAGLACIGCGACVDACPRGAI 50
PRK06273 PRK06273
ferredoxin; Provisional
 108-162 2.62e-08

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 51.25  E-value: 2.62e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056   108 EERCIACKLCEAICPAQAIT-IEAEPR--ADGSRRTTRYDIDMTKCIYCGFCQEACPV 162
Cdd:PRK06273  48 EELCIGCGGCANVCPTKAIEmIPVEPVkiTEGYVKTKIPKIDYEKCVYCLYCHDFCPV 105
FeFe_hydrog_B1 TIGR04105
[FeFe] hydrogenase, group B1/B3; See for descriptions of different groups.
 109-167 4.06e-08

[FeFe] hydrogenase, group B1/B3; See for descriptions of different groups.


Pssm-ID: 274983 [Multi-domain]  Cd Length: 462  Bit Score: 52.59  E-value: 4.06e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1935056    109 ERCIACKLCEAICPAQAIT------IEAEP-RADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVE 167
Cdd:TIGR04105 142 EKCIECGKCKKACPYNAIVeierpcEKACPvGAISSDEDGRAVIDYDKCISCGACMVACPFGAISD 207
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 110-165 9.76e-08

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 51.15  E-value: 9.76e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056   110 RCIACKLCEAICPAQAItIEAEPRADGSR----RTTRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:PRK14028 248 KCIMCRKCWLYCPDDAI-IEAWREAEGPRgrkfRMKMIDFDYQYCKGCGVCAEVCPTGAI 306
PRK13795 PRK13795
hypothetical protein; Provisional
 110-162 2.59e-07

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 50.38  E-value: 2.59e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1935056   110 RCIACKLCEAICPAQAITIEAEPRadgsrrttRYDIDMTKCIYCGFCQEACPV 162
Cdd:PRK13795 582 ECVGCGVCVGACPTGAIRIEEGKR--------KISVDEEKCIHCGKCTEVCPV 626
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 108-165 3.35e-07

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 48.02  E-value: 3.35e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIdMTKCIYCGF------CQEACPVDAI 165
Cdd:cd10554  84 EERCIGCKLCVLACPFGAIEMAPTTVPGVDWERGPRAV-AVKCDLCAGreggpaCVEACPTKAL 146
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
108-165 4.08e-07

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 48.91  E-value: 4.08e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  108 EERCIACKLCEAICPAQAItieaePRaDGSrrttrydIDMTKCIYCGFCQEACPVDAI 165
Cdd:COG0348 209 RGDCIDCGLCVKVCPMGID-----IR-KGE-------INQSECINCGRCIDACPKDAI 253
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 109-174 6.58e-07

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 47.53  E-value: 6.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056  109 ERCIACKLCEAICPAQAITI-EAEPRADGSRRTTRYDIdMTKCIYC------G---FCQEACPVDAIVEG----PNFEFS 174
Cdd:cd10551  83 DKCIGCRYCMAACPYGARYFnPEEPHEFGEVPVRPKGV-VEKCTFCyhrldeGllpACVEACPTGARIFGdlddPNSEVS 161
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 112-165 6.85e-07

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 46.85  E-value: 6.85e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 1935056  112 IACKLCEAICPAQAITIEaePRADGSRRTTrydIDMTKCIYCGFCQEACPVDAI 165
Cdd:cd10564  86 VECRSCQDACPTQAIRFR--PRLGGIALPE---LDADACTGCGACVSVCPVGAI 134
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
110-165 8.56e-07

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 48.48  E-value: 8.56e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 1935056  110 RCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:COG4624  53 RCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAI 108
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 98-166 9.80e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 46.61  E-value: 9.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056   98 EHALRRYPSG-----EERCIACKLCEAICPAQAITIEAEPRadgsrrttrydiDMTKCIYCGF---------CQEACPVD 163
Cdd:cd04410  64 TGAIYKDEDGivlidEDKCIGCGSCVEACPYGAIVFDPEPG------------KAVKCDLCGDrldeglepaCVKACPTG 131


                ...
gi 1935056  164 AIV 166
Cdd:cd04410 132 ALT 134
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
108-166 1.07e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 46.19  E-value: 1.07e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRADGSrrttrydidmTKCIYCGF------CQEACPVDAIV 166
Cdd:COG1142  80 EEKCIGCGLCVLACPFGAITMVGEKSRAVA----------VKCDLCGGreggpaCVEACPTGALR 134
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
111-165 1.07e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 46.19  E-value: 1.07e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 1935056  111 CIACKL--CEAICPAQAITieaepradgsRRTTRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:COG1142  52 CRHCEDapCAEVCPVGAIT----------RDDGAVVVDEEKCIGCGLCVLACPFGAI 98
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 111-169 1.12e-06

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 48.33  E-value: 1.12e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056   111 CIACKLCEAICPAQAITIEAEPRadgsrrttRYDIDMTKCIYCGFCQEACPVDAIVEGP 169
Cdd:PRK12771 512 CFECDNCYGACPQDAIIKLGPGR--------RYHFDYDKCTGCHICADVCPCGAIEMGP 562
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 75-165 1.46e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 47.16  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    75 LFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAE-PRADGsrrttrydidmtKCIYC 153
Cdd:NF038196 151 GPEKKKGFIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGkPVWGH------------NCTHC 218

                         90
                 ....*....|..
gi 1935056   154 GFCQEACPVDAI 165
Cdd:NF038196 219 LACIHRCPKEAI 230
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 102-166 1.85e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 45.65  E-value: 1.85e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056  102 RRYPSGEERCIACKLCE-----AICPAQAITIEAEpradgsrrTTRYDIDMTKCIYCGFCQEACPVDAIV 166
Cdd:cd10550  37 RFEPEGLDVPVVCRQCEdapcvEACPVGAISRDEE--------TGAVVVDEDKCIGCGMCVEACPFGAIR 98
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 99-166 2.25e-06

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 46.09  E-value: 2.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056   99 HALRRYPSG-----EERCIACKLCEAICPAQAITIEAEPRAdgsrrttrydidMTKCIYCGF---------CQEACPVDA 164
Cdd:COG0437  75 GATYKREDGivlvdYDKCIGCRYCVAACPYGAPRFNPETGV------------VEKCTFCADrldegllpaCVEACPTGA 142


                ..
gi 1935056  165 IV 166
Cdd:COG0437 143 LV 144
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 108-166 3.19e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 45.32  E-value: 3.19e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  108 EERCIA------CKLCEAICPAQAITIEAEpraDGSRRTTrydIDMTKCIYCGFCQEACPVD---AIV 166
Cdd:cd16373  90 KDRCLAwqggtdCGVCVEACPTEAIAIVLE---DDVLRPV---VDEDKCVGCGLCEYVCPVEppkAIV 151
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 108-161 4.34e-06

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 42.62  E-value: 4.34e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1935056    108 EERCIACKLCEAICPAQAITIEAEPRADGSRRTtryDIDMTKCIYCGFCQEACP 161
Cdd:pfam13237   6 PDKCIGCGRCTAACPAGLTRVGAIVERLEGEAV---RIGVWKCIGCGACVEACP 56
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
111-161 7.65e-06

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 42.09  E-value: 7.65e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1935056    111 CIACKLCEAICPAQAIT---IEAEPRADGSRRTTRYD---------IDMTKCIYCGFCQEACP 161
Cdd:pfam13484   1 CGSCGKCIDACPTGAIVgpeGVLDARRCISYLTIEKKglipdelrcLLGNRCYGCDICQDVCP 63
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 143-165 1.17e-05

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 40.69  E-value: 1.17e-05
                          10        20
                  ....*....|....*....|...
gi 1935056    143 YDIDMTKCIYCGFCQEACPVDAI 165
Cdd:pfam00037   1 VVIDEEKCIGCGACVEVCPVGAI 23
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 117-165 1.19e-05

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 44.17  E-value: 1.19e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 1935056  117 CEAICPAQAITIeaepRADGSRRttrydIDMTKCIYCGFCQEACPVDAI 165
Cdd:COG0437  68 CVKVCPTGATYK----REDGIVL-----VDYDKCIGCRYCVAACPYGAP 107
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 111-165 1.35e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 43.03  E-value: 1.35e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 1935056  111 CIACKL--CEAICPAQAItieaEPRADGSRRTTRydidmTKCIYCGFCQEACPVDAI 165
Cdd:cd16370  53 CRACEDppCAEACPTGAL----EPRKGGGVVLDK-----EKCIGCGNCVKACIVGAI 100
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 108-165 1.37e-05

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 45.12  E-value: 1.37e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1935056   108 EERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYdidmtKCIYCG------FCQEACPVDAI 165
Cdd:PRK12769  84 QQKCIGCKSCVVACPFGTMQIVLTPVAAGKVKATAH-----KCDLCAgrengpACVENCPADAL 142
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 110-165 2.87e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 42.63  E-value: 2.87e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056  110 RCIACKLCEAICPAQAITIeaEPRADGSR--RTTRYDIDMTKCIYCG-FCQEACPVDAI 165
Cdd:cd16373  15 LCIRCGLCVEACPTGVIQP--AGLEDGLEggRTPYLDPREGPCDLCCdACVEVCPTGAL 71
NapF COG1145
Ferredoxin [Energy production and conversion];
107-170 3.21e-05

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 43.56  E-value: 3.21e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1935056  107 GEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPN 170
Cdd:COG1145 141 EAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDG 204
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
109-171 3.48e-05

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 41.95  E-value: 3.48e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  109 ERCIACKLCEAICPAQAITIEAE---PRADGSRRTTRYDIDMtkCIYC--GFCQEACPVDAIVEGPNF 171
Cdd:COG1142  10 EKCIGCRTCEAACAVAHEGEEGEpflPRIRVVRKAGVSAPVQ--CRHCedAPCAEVCPVGAITRDDGA 75
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
108-165 3.53e-05

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 41.47  E-value: 3.53e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056   108 EERCIACKLCEAICPAQAITIeaepRADGSrrttrYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:PRK09623  50 ESKCVKCYICWKFCPEPAIYI----KEDGY-----VAIDYDYCKGCGICANECPTKAI 98
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 108-165 4.58e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 41.79  E-value: 4.58e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEpradgsrrtTRYdidMTKCIYCG---FCQEACPVDAI 165
Cdd:cd10550  79 EDKCIGCGMCVEACPFGAIRVDPE---------TGK---AIKCDLCGgdpACVKVCPTGAL 127
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 139-170 4.59e-05

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 40.41  E-value: 4.59e-05
                        10        20        30
                ....*....|....*....|....*....|....
gi 1935056  139 RTT--RYDIDMTKCIYCGFCQEACPVDAIVEGPN 170
Cdd:COG4231  11 RTTamRYVIDEDKCTGCGACVKVCPADAIEEGDG 44
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 108-165 5.78e-05

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 42.67  E-value: 5.78e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056  108 EERCIACKLCEAICPAQAITIEAE--PRadgsrrttrydIDMTKCIYCGFCQEACPVDAI 165
Cdd:COG2878 136 EYGCIGCGDCIKACPFDAIVGAAKgmHT-----------VDEDKCTGCGLCVEACPVDCI 184
PRK09898 PRK09898
ferredoxin-like protein;
108-165 7.21e-05

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 42.13  E-value: 7.21e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056   108 EERCIACKLCEAICPAQAITIEAEPRADgsrrttrydidmTKCIYCGFCQEACPVDAI 165
Cdd:PRK09898 153 HKRCIGCSACTTACPWMMATVNTESKKS------------SKCVLCGECANACPTGAL 198
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 117-165 8.30e-05

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 41.75  E-value: 8.30e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 1935056  117 CEAICPAQAITIeaepRADGsrrttRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:cd10551  61 CVKVCPTGATYK----REDG-----IVLVDYDKCIGCRYCMAACPYGAR 100
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 108-166 8.80e-05

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 41.32  E-value: 8.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056    108 EERCIACKLCEAICPAQAITieAEPRAdgsrrttRYDIDMTKCIYCGFCQEACPVDAIV 166
Cdd:TIGR01944 112 EDNCIGCTKCIQACPVDAIV--GAAKA-------MHTVIADECTGCDLCVEPCPTDCIE 161
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 145-180 1.04e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 39.31  E-value: 1.04e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 1935056  145 IDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEE 180
Cdd:COG1146   5 IDTDKCIGCGACVEVCPVDVLELDEEGKKALVINPE 40
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 108-169 1.15e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 40.45  E-value: 1.15e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  108 EERCIACKLCEAICPaQAITIEAEPRADGSRRTTRYDIDM----TKCIYCGF--CQEACPVDAIVEGP 169
Cdd:cd04410   5 LDRCIGCGTCEVACK-QEHGLRPGPDWSRIKVIEGGGLERaflpVSCMHCEDppCVKACPTGAIYKDE 71
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 108-136 1.27e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 38.92  E-value: 1.27e-04
                        10        20
                ....*....|....*....|....*....
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRADG 136
Cdd:COG1146  39 PEECIGCGACELVCPVGAITVEDDEPEEQ 67
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 117-166 1.37e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 40.62  E-value: 1.37e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 1935056  117 CEAICPAQAITIeaepRADGsrrTTRYDIDmtKCIYCGFCQEACPVDAIV 166
Cdd:cd16371  62 CVKVCPTGAITK----REDG---IVVVDQD--KCIGCGYCVWACPYGAPQ 102
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 102-165 1.60e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 40.30  E-value: 1.60e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056  102 RRYPSGEE-----RCIACKLCEAICPAQAITIeaepradGSRRTTRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:cd10564   1 RPPWAVDEalfldLCTRCGDCVEACPEGIIVR-------GDGGFPELDFSRGECTFCGACAEACPEGAL 62
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
108-167 1.69e-04

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 41.47  E-value: 1.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1935056   108 EERCIACKLCEAIC---PAQAITIEAepraDGSRRttrYDIDMTKCIYCGFCQEACPVDAIVE 167
Cdd:PRK08318 341 QDKCIGCGRCYIACedtSHQAIEWDE----DGTRT---PEVIEEECVGCNLCAHVCPVEGCIT 396
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 100-165 1.86e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 39.95  E-value: 1.86e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1935056  100 ALRRYPSG-----EERCIACKLCEAICPAQAITIEAEpradgsrrtTRYDIdmtKCIYCGFCQEACPVDAI 165
Cdd:cd16370  69 ALEPRKGGgvvldKEKCIGCGNCVKACIVGAIFWDEE---------TNKPI---ICIHCGYCARYCPHDVL 127
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 145-166 1.99e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 38.56  E-value: 1.99e-04
                        10        20
                ....*....|....*....|..
gi 1935056  145 IDMTKCIYCGFCQEACPVDAIV 166
Cdd:COG1149   8 IDEEKCIGCGLCVEVCPEGAIK 29
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 108-166 2.40e-04

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 39.24  E-value: 2.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056   108 EERCIACKLCEAICPAQAITIEAEpradgsrrttRYDI-DMTKCIYCGFCQEACPVDAIV 166
Cdd:PRK09624  50 RDKCVRCYLCYIYCPEPAIYLDEE----------GYPVfDYDYCKGCGICANECPTKAIE 99
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 136-176 3.57e-04

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 38.11  E-value: 3.57e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 1935056  136 GSRRTTRYDIDMTKCIYCGFCQEACPVDAI--VEGPNFEFSTE 176
Cdd:COG1144  18 GGWRVERPVVDEDKCIGCGLCWIVCPDGAIrvDDGKYYGIDYD 60
PRK06259 PRK06259
succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional
 89-161 3.84e-04

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional


Pssm-ID: 235756 [Multi-domain]  Cd Length: 486  Bit Score: 40.76  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    89 GPLSPRFRGEHALRRYPSGEER------CIACKLCEAICPAQAIT-------------IEAEPRADGSRRTTRYDIDMTK 149
Cdd:PRK06259 107 KSLRNYLQRKNEKITYPEDIEDikklrgCIECLSCVSTCPARKVSdypgptfmrqlarFAFDPRDEGDREKEAFDEGLYN 186

                         90
                 ....*....|..
gi 1935056   150 CIYCGFCQEACP 161
Cdd:PRK06259 187 CTTCGKCVEVCP 198
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 145-171 4.18e-04

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 39.40  E-value: 4.18e-04
                          10        20
                  ....*....|....*....|....*..
gi 1935056    145 IDMTKCIYCGFCQEACPVDAIVEGPNF 171
Cdd:TIGR01944 110 IDEDNCIGCTKCIQACPVDAIVGAAKA 136
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 110-165 4.58e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 38.80  E-value: 4.58e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  110 RCIACK--LCEAICPAQAITIEAepraDGSRRttrydIDMTKCIYCGFCQEACPVDAI 165
Cdd:cd16374  42 RCRHCEdaPCMEVCPTGAIYRDE----DGAVL-----VDPDKCIGCGMCAMACPFGVP 90
PRK09898 PRK09898
ferredoxin-like protein;
109-161 4.59e-04

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 39.82  E-value: 4.59e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1935056   109 ERCIACK--LCEAICPAQAITIEAEPRAdgsrrttrYDIDMTKCIYCGFCQEACP 161
Cdd:PRK09898 121 DTCRQCKepQCMNVCPIGAITWQQKEGC--------ITVDHKRCIGCSACTTACP 167
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 108-179 4.60e-04

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 38.16  E-value: 4.60e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1935056   108 EERCIACKLCEAICPAQAITIEAEPRAD-GSRRTTRYDidmTKCIYCGFCQEACPVDAI--VEGPNFEFSTETHE 179
Cdd:PRK09626  15 ESRCKACDICVSVCPAGVLAMRIDPHAVlGKMIKVVHP---ESCIGCRECELHCPDFAIyvADRKEFKFAKLSKE 86
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 111-166 5.22e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 38.47  E-value: 5.22e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  111 CIACKLCEAICPAQAITieaepradgsrRTTR--YDIDMTKCIYCGFCQEACPVDAIV 166
Cdd:cd16372  49 CNQCGECIDVCPTGAIT-----------RDANgvVMINKKLCVGCLMCVGFCPEGAMF 95
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 108-170 6.10e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 38.47  E-value: 6.10e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1935056  108 EERCIACKLCEAICpaqAITIEAEPRADGSR---RTTRYDIDMTKCIYCGFCQEACPVDAIVEGPN 170
Cdd:cd16372   7 PEKCIGCLQCEEAC---SKTFFKEEDREKSCiriTETEGGYAINVCNQCGECIDVCPTGAITRDAN 69
RDH TIGR02486
reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S ...
 111-161 7.00e-04

reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene.


Pssm-ID: 274158  Cd Length: 314  Bit Score: 39.73  E-value: 7.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1935056    111 CIACKLCEAICPAQAITIEAEPRADGSRRTTRYD----------IDMTKCI----------YCGFCQEACP 161
Cdd:TIGR02486 207 CETCGKCADECPSGAISKGGEPTWDPEDSNGDPPgennpglkwqYDGWRCLlfrcynegggGCGVCQAVCP 277
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 109-165 8.23e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 37.94  E-value: 8.23e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056  109 ERCIACKLCEAIC---------PAQA-ITIEAEPRADgsrrttrYDIDMTkCIYCG--FCQEACPVDAI 165
Cdd:cd10550   6 EKCTGCRTCELACslkhegvfnPSLSrIRVVRFEPEG-------LDVPVV-CRQCEdaPCVEACPVGAI 66
PRK06991 PRK06991
electron transport complex subunit RsxB;
145-169 1.20e-03

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 39.01  E-value: 1.20e-03
                         10        20
                 ....*....|....*....|....*
gi 1935056   145 IDMTKCIYCGFCQEACPVDAIVEGP 169
Cdd:PRK06991  82 IDEQLCIGCTLCMQACPVDAIVGAP 106
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 100-165 1.22e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 37.32  E-value: 1.22e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1935056  100 ALRRYPSG-----EERCIACKLCEAICPAQAITIEAEPradgsrrttrydIDMTKCIYCGFCQEACPVDAI 165
Cdd:cd16372  63 AITRDANGvvminKKLCVGCLMCVGFCPEGAMFKHEDY------------PEPFKCIACGICVKACPTGAL 121
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 109-176 1.26e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 37.64  E-value: 1.26e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1935056  109 ERCIACKLCEAICPAQAITIEAEPRAdgsrrttrydidMTKCIYCG---------FCQEACPVDAIVEGPNFEFSTE 176
Cdd:cd16374  73 DKCIGCGMCAMACPFGVPRFDPSLKV------------AVKCDLCIdrrregklpACVEACPTGALKFGDIEELLKE 137
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 108-127 1.81e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 34.53  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|
gi 1935056    108 EERCIACKLCEAICPAQAIT 127
Cdd:pfam00037   5 EEKCIGCGACVEVCPVGAIT 24
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 144-170 1.89e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 36.99  E-value: 1.89e-03
                        10        20
                ....*....|....*....|....*..
gi 1935056  144 DIDMTKCIYCGFCQEACPVDAIVEGPN 170
Cdd:cd10549   2 KYDPEKCIGCGICVKACPTDAIELGPN 28
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 140-165 2.16e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 35.41  E-value: 2.16e-03
                        10        20
                ....*....|....*....|....*.
gi 1935056  140 TTRYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:COG2221   7 TWPPKIDEEKCIGCGLCVAVCPTGAI 32
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 108-134 2.52e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 35.40  E-value: 2.52e-03
                        10        20
                ....*....|....*....|....*..
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRA 134
Cdd:COG4231  50 PDLCIGCGSCVQVCPVDAIKLEKRVPE 76
PRK12576 PRK12576
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
61-163 2.55e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 237143 [Multi-domain]  Cd Length: 279  Bit Score: 37.81  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935056    61 WTELFRGLGMTLSYLFRepatiNYPFEKGPLSPRFRGEHALRRYPSGEerCIACKLCEAICPAQAITIE----------- 129
Cdd:PRK12576 111 FDEFYERMFKVKPRLYR-----AKEVLEGKAEHRLKPEDQKELWKFAQ--CIWCGLCVSACPVVAIDPEflgpaahakgy 183

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 1935056   130 ---AEPRADGSRRTTRYDIDMT-KCIYCGFCQEACPVD 163
Cdd:PRK12576 184 rflADPRDTITEERMKILIDSSwRCTYCYSCSNVCPRD 221
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 108-129 2.82e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 36.61  E-value: 2.82e-03
                        10        20
                ....*....|....*....|..
gi 1935056  108 EERCIACKLCEAICPAQAITIE 129
Cdd:cd10549 107 KEKCIGCGICAEVCPVNAIKLV 128
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 108-172 2.89e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 37.67  E-value: 2.89e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPrADGSRRTTRYDIDMTKCIYC-GFCQEACPVDAIVEGPNFE 172
Cdd:COG2878 166 EDKCTGCGLCVEACPVDCIEMVPVS-PTVVVSSWDKGKAVRKVVGCiGLCCKKCCPAAAITVNNLA 230
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
108-143 3.16e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 35.09  E-value: 3.16e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEPRADGSRRTTRY 143
Cdd:COG2768  39 PEKCIGCGACIEVCPVGAIKIEWEEDEEFQEKMAEY 74
PRK05113 PRK05113
electron transport complex protein RnfB; Provisional
 145-166 3.17e-03

electron transport complex protein RnfB; Provisional


Pssm-ID: 235347 [Multi-domain]  Cd Length: 191  Bit Score: 37.23  E-value: 3.17e-03
                         10        20
                 ....*....|....*....|..
gi 1935056   145 IDMTKCIYCGFCQEACPVDAIV 166
Cdd:PRK05113 111 IDEDNCIGCTKCIQACPVDAIV 132
NapF COG1145
Ferredoxin [Energy production and conversion];
108-132 3.91e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 37.39  E-value: 3.91e-03
                        10        20
                ....*....|....*....|....*
gi 1935056  108 EERCIACKLCEAICPAQAITIEAEP 132
Cdd:COG1145 212 PDKCIGCGACVKVCPVGAISLEPKE 236
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 108-177 3.92e-03

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 37.17  E-value: 3.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1935056   108 EERCIACKLCEAICPAQAITIEaepraDGSRRTTrydiDMTKCIYCGFCQEACPVDAIVEG--PN-FEFSTET 177
Cdd:PRK00783 168 SEDCDECEKCVEACPRGVLELK-----EGKLVVT----DLLNCSLCKLCERACPGKAIRVSddENkFIFTVES 231
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 117-165 4.01e-03

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 36.51  E-value: 4.01e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 1935056  117 CEAICPAQAITIEAepraDGSrrttrYDIDMTKCIYCGFCQEACPVDAI 165
Cdd:cd10562  78 CVKVCPTGALYKTE----NGA-----VVVDEDKCIGCGYCVAACPFDVP 117
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 100-166 4.88e-03

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 36.08  E-value: 4.88e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  100 ALRRYP-SG-----EERCIACKLCEAICPAQAITIEAEPRAdgsrrttrydidMTKCIYCGF-----CQEACPVDAIV 166
Cdd:cd10563  73 AMHKDPeTGivihdEEKCVGCWMCVMVCPYGAIRPDKERKV------------ALKCDLCPDretpaCVEACPTGALV 138
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 110-163 5.69e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 34.21  E-value: 5.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1935056    110 RCIACKLCEAICPA---------QAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVD 163
Cdd:pfam13183   1 RCIRCGACLAACPVylvtggrfpGDPRGGAAALLGRLEALEGLAEGLWLCTLCGACTEVCPVG 63
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 112-165 6.34e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 35.70  E-value: 6.34e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935056  112 IACKLCE-----AICPAQAITieaepRADGSRRttrydIDMTKCIYCGFCQEACPVDAI 165
Cdd:cd10554  54 VQCRQCEdapcaNVCPVGAIS-----QEDGVVQ-----VDEERCIGCKLCVLACPFGAI 102
QueG COG1600
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 108-161 7.98e-03

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 36.34  E-value: 7.98e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1935056  108 EERCIACKLCEAICPAQAITieaEPradgsrrttrYDIDMTKCI-Y-----------------------CGFCQEACP 161
Cdd:COG1600 183 EDHCGSCTRCLDACPTGAIV---AP----------YVLDARRCIsYltielkgpipeelrpkmgnriygCDDCQDVCP 247
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 109-161 8.14e-03

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 35.11  E-value: 8.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1935056   109 ERCIACKLCEAICPAQAITieaepradgSRRTTRYDIDMTKCIYCGFCQEACP 161
Cdd:PRK09625  59 EICINCFNCWVYCPDAAIL---------SRDKKLKGVDYSHCKGCGVCVEVCP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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