NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|180195|gb|AAA58419|]

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caldesmon [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

Caldesmon

Caldesmon;

386-780

2.72e-125

Caldesmon;

:

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 384.60 E-value: 2.72e-125

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     386 QKRNKQLEEKKRAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVlkKQGEEKGTKVQAKREKLQE-DKPTFKKEEIK 464
Cdd:pfam02029 103 RKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEV--RQAEEEGEEEEDKSEEAEEvPTENFAKEEVK 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     465 DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENtfSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544
Cdd:pfam02029 181 DEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTK--RRQGGLSQSQEREEEAEVFLEAEQKLEELRRRRQ 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     545 ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 624
Cdd:pfam02029 259 EKESEEFEKLRQKQQEAELELEELKKKREERRKLLEEEEQRRKQEEAERKLREEEEKRRMKEEIERRRAEAAEKRQKLPE 338

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     625 DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIE-GTKSAKPTKPAASDLP 703
Cdd:pfam02029 339 DSSSEGKKPFKCFSPKGSSLKITERAEFLNKSLQKSSSVKKTHPPAVVSKIDSRLEQYTSAIEsSTKEAKPTKPAASDLP 418

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 180195     704 VPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 780
Cdd:pfam02029 419 VPAEGVRNIKSMWEKGNVFSSPGAKGTPNKETAGLKVGVASRINEWLKKTPEGSKSPAPKPSDLRPGDVSGKRNLWE 495

Caldesmon super family

Caldesmon;

31-291

4.97e-20

Caldesmon;

The actual alignment was detected with superfamily member pfam02029:

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 94.16 E-value: 4.97e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195      31 DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVpdEEAKTTTTNTQVEGDDEAAFLERLARREERRQKR 110
Cdd:pfam02029   1 IEDEEEAARERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSY--EEDSELKPSGQGGLDEEEAFLDRTAKREERRQKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     111 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190
Cdd:pfam02029  79 LQEALERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     191 EEEEEEKPKRG----SIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAE 266
Cdd:pfam02029 159 EEDKSEEAEEVptenFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREE 238

                         250       260
                  ....*....|....*....|....*.
gi 180195     267 AERARLEAEER-ERIKAEQDKKIADE 291
Cdd:pfam02029 239 EAEVFLEAEQKlEELRRRRQEKESEE 264

Name

Accession

Description

Interval

E-value

Caldesmon

Caldesmon;

386-780

2.72e-125

Caldesmon;

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 384.60 E-value: 2.72e-125

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     386 QKRNKQLEEKKRAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVlkKQGEEKGTKVQAKREKLQE-DKPTFKKEEIK 464
Cdd:pfam02029 103 RKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEV--RQAEEEGEEEEDKSEEAEEvPTENFAKEEVK 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     465 DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENtfSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544
Cdd:pfam02029 181 DEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTK--RRQGGLSQSQEREEEAEVFLEAEQKLEELRRRRQ 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     545 ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 624
Cdd:pfam02029 259 EKESEEFEKLRQKQQEAELELEELKKKREERRKLLEEEEQRRKQEEAERKLREEEEKRRMKEEIERRRAEAAEKRQKLPE 338

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     625 DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIE-GTKSAKPTKPAASDLP 703
Cdd:pfam02029 339 DSSSEGKKPFKCFSPKGSSLKITERAEFLNKSLQKSSSVKKTHPPAVVSKIDSRLEQYTSAIEsSTKEAKPTKPAASDLP 418

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 180195     704 VPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 780
Cdd:pfam02029 419 VPAEGVRNIKSMWEKGNVFSSPGAKGTPNKETAGLKVGVASRINEWLKKTPEGSKSPAPKPSDLRPGDVSGKRNLWE 495

Caldesmon

Caldesmon;

31-291

4.97e-20

Caldesmon;

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 94.16 E-value: 4.97e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195      31 DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVpdEEAKTTTTNTQVEGDDEAAFLERLARREERRQKR 110
Cdd:pfam02029   1 IEDEEEAARERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSY--EEDSELKPSGQGGLDEEEAFLDRTAKREERRQKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     111 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190
Cdd:pfam02029  79 LQEALERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     191 EEEEEEKPKRG----SIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAE 266
Cdd:pfam02029 159 EEDKSEEAEEVptenFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREE 238

                         250       260
                  ....*....|....*....|....*.
gi 180195     267 AERARLEAEER-ERIKAEQDKKIADE 291
Cdd:pfam02029 239 EAEVFLEAEQKlEELRRRRQEKESEE 264

PTZ00121

MAEBL; Provisional

255-689

3.48e-05

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 3.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     255 EKMEEEDKERAEAERARLEAE---ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRI 331
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKkkaDEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     332 KEEEKRAAEERQrikeeekraaeeRQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKRAMQETKIKGEKVEQ 411
Cdd:PTZ00121 1450 KKKAEEAKKAEE------------AKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKK 1517

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     412 KIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 491
Cdd:PTZ00121 1518 AEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEV 1597

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     492 KSQNGEFMTHKLKHTENTfSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK 571
Cdd:PTZ00121 1598 MKLYEEEKKMKAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKK 1676

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     572 REERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER-- 649
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEek 1756

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 180195     650 ---AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGT 689
Cdd:PTZ00121 1757 kkiAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKK 1799

Name

Accession

Description

Interval

E-value

Caldesmon

Caldesmon;

386-780

2.72e-125

Caldesmon;

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 384.60 E-value: 2.72e-125

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     386 QKRNKQLEEKKRAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVlkKQGEEKGTKVQAKREKLQE-DKPTFKKEEIK 464
Cdd:pfam02029 103 RKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEV--RQAEEEGEEEEDKSEEAEEvPTENFAKEEVK 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     465 DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENtfSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544
Cdd:pfam02029 181 DEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTK--RRQGGLSQSQEREEEAEVFLEAEQKLEELRRRRQ 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     545 ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 624
Cdd:pfam02029 259 EKESEEFEKLRQKQQEAELELEELKKKREERRKLLEEEEQRRKQEEAERKLREEEEKRRMKEEIERRRAEAAEKRQKLPE 338

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     625 DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIE-GTKSAKPTKPAASDLP 703
Cdd:pfam02029 339 DSSSEGKKPFKCFSPKGSSLKITERAEFLNKSLQKSSSVKKTHPPAVVSKIDSRLEQYTSAIEsSTKEAKPTKPAASDLP 418

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 180195     704 VPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 780
Cdd:pfam02029 419 VPAEGVRNIKSMWEKGNVFSSPGAKGTPNKETAGLKVGVASRINEWLKKTPEGSKSPAPKPSDLRPGDVSGKRNLWE 495

Caldesmon

Caldesmon;

31-291

4.97e-20

Caldesmon;

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 94.16 E-value: 4.97e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195      31 DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVpdEEAKTTTTNTQVEGDDEAAFLERLARREERRQKR 110
Cdd:pfam02029   1 IEDEEEAARERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSY--EEDSELKPSGQGGLDEEEAFLDRTAKREERRQKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     111 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190
Cdd:pfam02029  79 LQEALERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     191 EEEEEEKPKRG----SIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAE 266
Cdd:pfam02029 159 EEDKSEEAEEVptenFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREE 238

                         250       260
                  ....*....|....*....|....*.
gi 180195     267 AERARLEAEER-ERIKAEQDKKIADE 291
Cdd:pfam02029 239 EAEVFLEAEQKlEELRRRRQEKESEE 264

PTZ00121

MAEBL; Provisional

255-689

3.48e-05

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 3.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     255 EKMEEEDKERAEAERARLEAE---ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRI 331
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKkkaDEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     332 KEEEKRAAEERQrikeeekraaeeRQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKRAMQETKIKGEKVEQ 411
Cdd:PTZ00121 1450 KKKAEEAKKAEE------------AKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKK 1517

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     412 KIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 491
Cdd:PTZ00121 1518 AEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEV 1597

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     492 KSQNGEFMTHKLKHTENTfSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK 571
Cdd:PTZ00121 1598 MKLYEEEKKMKAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKK 1676

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     572 REERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER-- 649
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEek 1756

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 180195     650 ---AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGT 689
Cdd:PTZ00121 1757 kkiAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKK 1799

PTZ00121

MAEBL; Provisional

248-651

8.98e-05

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.29 E-value: 8.98e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     248 SDEISHHEKMEEEDKERAEAERARlEAEERERiKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEE 327
Cdd:PTZ00121 1292 ADEAKKAEEKKKADEAKKKAEEAK-KADEAKK-KAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     328 RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKRAMQETKIKGE 407
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     408 KVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKG 487
Cdd:PTZ00121 1450 KKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKK 1529

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     488 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET--ESEEFEKLKQKQQEAALEL 565
Cdd:PTZ00121 1530 AEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaeEARIEEVMKLYEEEKKMKA 1609

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     566 EELKKKREERRKVLEEEEQRRKQEEADRKLREEEEkrrlkeeiERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLK 645
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE--------EKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAK 1681


                  ....*.
gi 180195     646 IEERAE 651
Cdd:PTZ00121 1682 KAEEDE 1687

PTZ00121

MAEBL; Provisional

214-664

6.20e-04

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.59 E-value: 6.20e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     214 EKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDK-----ERAEAERARLEAEEREriKAEQDKKI 288
Cdd:PTZ00121 1246 EEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEakkaeEKKKADEAKKKAEEAK--KADEAKKK 1323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     289 ADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRiKEEEKRAAEERQRIKEEEKRAAE 368
Cdd:PTZ00121 1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKK-ADAAKKKAEEKKKADEAKKKAEE 1402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     369 ERQRARAEEEEKAKVEEQKRNKQLEEKKRAMQETKIKGEKVEQKIEGKWVNE--------KKAQEDKLQTAVLKKQGEEK 440
Cdd:PTZ00121 1403 DKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEeakkaeeaKKKAEEAKKADEAKKKAEEA 1482

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     441 GTKVQAKRE------------KLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN 508
Cdd:PTZ00121 1483 KKADEAKKKaeeakkkadeakKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEE 1562

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     509 T-----FSRPGGRASVDTKEAEGAPQVEagKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEE 583
Cdd:PTZ00121 1563 KkkaeeAKKAEEDKNMALRKAEEAKKAE--EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKK 1640

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 180195     584 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG-SSLKIEERAEFLNKSVQKSSG 662
Cdd:PTZ00121 1641 KEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAeEAKKAEELKKKEAEEKKKAEE 1720


                  ..
gi 180195     663 VK 664
Cdd:PTZ00121 1721 LK 1722

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options